{ "title": "Google Research Application Summary", "body": { "content": [ { "endIndex": 1, "sectionBreak": { "sectionStyle": { "columnSeparatorStyle": "NONE", "contentDirection": "LEFT_TO_RIGHT", "sectionType": "CONTINUOUS" } } }, { "startIndex": 1, "endIndex": 156, "paragraph": { "elements": [ { "startIndex": 1, "endIndex": 156, "textRun": { "content": "Development of a polygenic risk score for Asthma and Chronic Obstructive Pulmonary Disease: prelude to understanding the genetic risk patterns for COVID19\n", "textStyle": {} } } ], "paragraphStyle": { "headingId": "h.dw7tcxi4kqbx", "namedStyleType": "TITLE", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 156, "endIndex": 157, "paragraph": { "elements": [ { "startIndex": 156, "endIndex": 157, "textRun": { "content": "\n", "textStyle": { "bold": true, "underline": true } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 157, "endIndex": 174, "paragraph": { "elements": [ { "startIndex": 157, "endIndex": 174, "textRun": { "content": "Research problem\n", "textStyle": { "bold": true, "underline": true } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 174, "endIndex": 175, "paragraph": { "elements": [ { "startIndex": 174, "endIndex": 175, "textRun": { "content": "\n", "textStyle": { "bold": true, "underline": true } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 175, "endIndex": 2198, "paragraph": { "elements": [ { "startIndex": 175, "endIndex": 2198, "textRun": { "content": "Chronic respiratory diseases, including children\u2019s and adult asthma and chronic obstructive pulmonary diseases account for a significant burden of illnesses and disabilities throughout the world. The WHO has estimated that 65 million people have moderate to severe chronic obstructive pulmonary disease (COPD), corresponding to 5% of all deaths globally, and asthma affects over 200 million people worldwide [1]. In particular, these significantly account for ambulatory care sensitive hospitalisations -- or expenditure and resources diverted towards hospital inpatient care for diseases that would otherwise be controlled in outpatients [2]. While the impact of asthma and COPD can be partly explained by lifestyle (smoking and exposure to allergen), the role of multiple genes in the pathogenesis and development of adult and childhood asthma and copd is an important determinant of health services. These help to classify using machine learning approaches as to how to best organise health services for the segment of population genetically at high risk of respiratory illness-related health services utilisation [3]. In particular, both these respiratory illnesses are harbingers of worse prognosis for respiratory virus related illness notably COVID19 [4]. Therefore, a relevant problem that needs addressing is the role of polygenic inheritance of asthma and COPD and their relationship between health services utilisation and prognoses in respiratory viral outbreaks such as SARS and COVID19. In this research, we will partly address this by first constructing a polygenic risk score to stratify individuals at high or moderate risk of Asthma and COPD related hospitalisations. In a follow up to this study dependent on the results generated from this, we aim to investigate the polygenic risk factors for worse prognosis of COVID19. This work will enable targeted public health interventions at various levels: containment of epidemics and also optimise health services utilisation and access to primary care. \n", "textStyle": {} } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 2198, "endIndex": 2199, "paragraph": { "elements": [ { "startIndex": 2198, "endIndex": 2199, "textRun": { "content": "\n", "textStyle": { "bold": true, "underline": true } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 2199, "endIndex": 2220, "paragraph": { "elements": [ { "startIndex": 2199, "endIndex": 2220, "textRun": { "content": "GCP tools to be used\n", "textStyle": { "bold": true, "underline": true } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 2220, "endIndex": 2221, "paragraph": { "elements": [ { "startIndex": 2220, "endIndex": 2221, 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These set of polygenic risk scores will be validated in a future study for those individuals in New Zealand who were diagnosed with positive Covid-19 infection between March and September of 2020. Other outcomes from this project will be a protocol that other researchers can replicate and build on; a git repository that will contain codes and data that other researchers can fork and build from, and a set of journal articles, preprint publications, tutorials, and report that will add to the growing knowledge base on the polygenic risk profile of asthma and chronic obstructive pulmonary diseases. \n", "textStyle": {} } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 6116, "endIndex": 6117, "paragraph": { "elements": [ { "startIndex": 6116, "endIndex": 6117, "textRun": { "content": "\n", "textStyle": {} } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 6117, "endIndex": 6159, "paragraph": { "elements": [ { "startIndex": 6117, "endIndex": 6159, "textRun": { "content": "How GCP can support the project in future\n", "textStyle": { "bold": true, "underline": true } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 6159, "endIndex": 6160, "paragraph": { "elements": [ { "startIndex": 6159, "endIndex": 6160, "textRun": { "content": "\n", "textStyle": {} } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 6160, "endIndex": 6623, "paragraph": { "elements": [ { "startIndex": 6160, "endIndex": 6623, "textRun": { "content": "We design this to be a preliminary investigation of the genetic risk factors that can determine the pathology and risk for respiratory viral infections such as COVID19 and SARS. In the next phase of the work, we plan to genotype a section of NZ based population who were diagnosed with COVID19 and who were hospitalised. We would develop predictive and explanatory models based on such genotyped data. 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L., & Korb, J. (2001). Ambulatory care sensitive hospitalizations and emergency visits: Experiences of Medicaid patients using federally qualified health centers. ", "textStyle": {} } }, { "startIndex": 6919, "endIndex": 6931, "textRun": { "content": "Medical Care", "textStyle": { "italic": true } } }, { "startIndex": 6931, "endIndex": 6942, "textRun": { "content": ", 551\u2013561.\n", "textStyle": {} } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 6942, "endIndex": 7303, "paragraph": { "elements": [ { "startIndex": 6942, "endIndex": 7209, "textRun": { "content": "[3]: Belsky, D. W., Sears, M. R., Hancox, R. J., Harrington, H., Houts, R., Moffitt, T. E., Sugden, K., Williams, B., Poulton, R., & Caspi, A. (2013). Polygenic risk and the development and course of asthma: An analysis of data from a four-decade longitudinal study. ", "textStyle": {} } }, { "startIndex": 7209, "endIndex": 7240, "textRun": { "content": "The Lancet Respiratory Medicine", "textStyle": { "italic": true } } }, { "startIndex": 7240, "endIndex": 7242, "textRun": { "content": ", ", "textStyle": {} } }, { "startIndex": 7242, "endIndex": 7243, "textRun": { "content": "1", "textStyle": { "italic": true } } }, { "startIndex": 7243, "endIndex": 7256, "textRun": { "content": "(6), 453\u2013461.", "textStyle": {} } }, { "startIndex": 7256, "endIndex": 7257, "textRun": { "content": " ", "textStyle": { "link": { "url": "https://doi.org/10.1016/S2213-2600(13)70101-2" } } } }, { "startIndex": 7257, "endIndex": 7302, "textRun": { "content": "https://doi.org/10.1016/S2213-2600(13)70101-2", "textStyle": { "underline": true, "foregroundColor": { "color": { "rgbColor": { "red": 0.06666667, "green": 0.33333334, "blue": 0.8 } } }, "link": { "url": "https://doi.org/10.1016/S2213-2600(13)70101-2" } } } }, { "startIndex": 7302, "endIndex": 7303, "textRun": { "content": "\n", "textStyle": { "underline": true, "foregroundColor": { "color": { "rgbColor": { "red": 0.06666667, "green": 0.33333334, "blue": 0.8 } } } } } } ], "paragraphStyle": { "namedStyleType": "NORMAL_TEXT", "direction": "LEFT_TO_RIGHT" } } }, { "startIndex": 7303, "endIndex": 7407, "paragraph": { "elements": [ { "startIndex": 7303, "endIndex": 7398, "textRun": { "content": "[4]: Johnston, S. 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