<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/1999/REC-html401-19991224/loose.dtd"> <html><head><title>Details for gene set FOSL1_TARGETS[GSEA]</title><link href='xtools.css' rel='stylesheet'><link href='http://www.gsea-msigdb.org/gsea/images/XBench.gif' rel='shortcut icon'></head><body><div class='keyValTable'><table cols='2' border='0'><th class='keyValTable'></th><th class='keyValTable'></th><tr><td>Dataset</td><td>NF1_GRD_exprs.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl_repos</td></tr><tr><td>Phenotype</td><td>NF1_GRD_phenotype.cls#GRD_versus_Ctrl_repos</td></tr><tr><td>Upregulated in class</td><td>Ctrl</td></tr><tr><td>GeneSet</td><td>FOSL1_TARGETS</td></tr><tr><td>Enrichment Score (ES)</td><td>-0.36444262</td></tr><tr><td>Normalized Enrichment Score (NES)</td><td>-1.3888106</td></tr><tr><td>Nominal p-value</td><td>0.053359684</td></tr><tr><td>FDR q-value</td><td>0.037134517</td></tr><tr><td>FWER p-Value</td><td>0.143</td></tr><caption class='table'>Table: GSEA Results Summary</caption></table></div><br><div class='image'><img name='enplot_FOSL1_TARGETS' src='enplot_FOSL1_TARGETS_30.png'><br><br><caption>Fig 1: Enrichment plot: FOSL1_TARGETS    <br> Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List</caption></div><br><div class='richTable'><table cols='9' border='1'><th class='richTable'></th><th class='richTable'>PROBE</th><th class='richTable'>DESCRIPTION<br>(from dataset)</th><th class='richTable'>GENE SYMBOL</th><th class='richTable'>GENE_TITLE</th><th class='richTable'>RANK IN GENE LIST</th><th class='richTable'>RANK METRIC SCORE</th><th class='richTable'>RUNNING ES</th><th class='richTable'>CORE ENRICHMENT</th><tr><td class='lessen'>1</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TPM1'>TPM1</a></td><td>TPM1</td><td></td><td></td><td>120</td><td>0.116</td><td>0.0428</td><td>No</td></tr><tr><td class='lessen'>2</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TGFBI'>TGFBI</a></td><td>TGFBI</td><td></td><td></td><td>137</td><td>0.111</td><td>0.0883</td><td>No</td></tr><tr><td class='lessen'>3</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LAMB1'>LAMB1</a></td><td>LAMB1</td><td></td><td></td><td>150</td><td>0.108</td><td>0.1328</td><td>No</td></tr><tr><td class='lessen'>4</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=FZD3'>FZD3</a></td><td>FZD3</td><td></td><td></td><td>425</td><td>0.081</td><td>0.1541</td><td>No</td></tr><tr><td class='lessen'>5</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=STAT3'>STAT3</a></td><td>STAT3</td><td></td><td></td><td>496</td><td>0.078</td><td>0.1835</td><td>No</td></tr><tr><td class='lessen'>6</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TGFBR2'>TGFBR2</a></td><td>TGFBR2</td><td></td><td></td><td>835</td><td>0.065</td><td>0.1948</td><td>No</td></tr><tr><td class='lessen'>7</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LAMA4'>LAMA4</a></td><td>LAMA4</td><td></td><td></td><td>1334</td><td>0.054</td><td>0.1943</td><td>No</td></tr><tr><td class='lessen'>8</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=VIM'>VIM</a></td><td>VIM</td><td></td><td></td><td>1546</td><td>0.051</td><td>0.2056</td><td>No</td></tr><tr><td class='lessen'>9</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=RAC3'>RAC3</a></td><td>RAC3</td><td></td><td></td><td>2573</td><td>0.039</td><td>0.1742</td><td>No</td></tr><tr><td class='lessen'>10</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=BMP7'>BMP7</a></td><td>BMP7</td><td></td><td></td><td>3061</td><td>0.035</td><td>0.1662</td><td>No</td></tr><tr><td class='lessen'>11</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGA2'>ITGA2</a></td><td>ITGA2</td><td></td><td></td><td>3297</td><td>0.033</td><td>0.1691</td><td>No</td></tr><tr><td class='lessen'>12</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=EGFR'>EGFR</a></td><td>EGFR</td><td></td><td></td><td>3517</td><td>0.031</td><td>0.1720</td><td>No</td></tr><tr><td class='lessen'>13</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TPM2'>TPM2</a></td><td>TPM2</td><td></td><td></td><td>3817</td><td>0.029</td><td>0.1704</td><td>No</td></tr><tr><td class='lessen'>14</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=CDH4'>CDH4</a></td><td>CDH4</td><td></td><td></td><td>3939</td><td>0.029</td><td>0.1767</td><td>No</td></tr><tr><td class='lessen'>15</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=CDH1'>CDH1</a></td><td>CDH1</td><td></td><td></td><td>4551</td><td>0.025</td><td>0.1588</td><td>No</td></tr><tr><td class='lessen'>16</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=MMP16'>MMP16</a></td><td>MMP16</td><td></td><td></td><td>6212</td><td>0.017</td><td>0.0888</td><td>No</td></tr><tr><td class='lessen'>17</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ETS1'>ETS1</a></td><td>ETS1</td><td></td><td></td><td>6432</td><td>0.016</td><td>0.0853</td><td>No</td></tr><tr><td class='lessen'>18</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=NRP1'>NRP1</a></td><td>NRP1</td><td></td><td></td><td>6636</td><td>0.015</td><td>0.0821</td><td>No</td></tr><tr><td class='lessen'>19</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=FN1'>FN1</a></td><td>FN1</td><td></td><td></td><td>7138</td><td>0.013</td><td>0.0642</td><td>No</td></tr><tr><td class='lessen'>20</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=AXL'>AXL</a></td><td>AXL</td><td></td><td></td><td>7543</td><td>0.011</td><td>0.0502</td><td>No</td></tr><tr><td class='lessen'>21</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ZEB1'>ZEB1</a></td><td>ZEB1</td><td></td><td></td><td>8268</td><td>0.009</td><td>0.0202</td><td>No</td></tr><tr><td class='lessen'>22</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LAMC2'>LAMC2</a></td><td>LAMC2</td><td></td><td></td><td>8418</td><td>0.008</td><td>0.0166</td><td>No</td></tr><tr><td class='lessen'>23</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=EPCAM'>EPCAM</a></td><td>EPCAM</td><td></td><td></td><td>8467</td><td>0.008</td><td>0.0177</td><td>No</td></tr><tr><td class='lessen'>24</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=WNT10B'>WNT10B</a></td><td>WNT10B</td><td></td><td></td><td>8596</td><td>0.007</td><td>0.0149</td><td>No</td></tr><tr><td class='lessen'>25</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LAMC1'>LAMC1</a></td><td>LAMC1</td><td></td><td></td><td>8664</td><td>0.007</td><td>0.0148</td><td>No</td></tr><tr><td class='lessen'>26</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=JUN'>JUN</a></td><td>JUN</td><td></td><td></td><td>9021</td><td>0.006</td><td>0.0007</td><td>No</td></tr><tr><td class='lessen'>27</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=RAC2'>RAC2</a></td><td>RAC2</td><td></td><td></td><td>9455</td><td>0.004</td><td>-0.0176</td><td>No</td></tr><tr><td class='lessen'>28</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=WNT16'>WNT16</a></td><td>WNT16</td><td></td><td></td><td>9790</td><td>0.003</td><td>-0.0318</td><td>No</td></tr><tr><td class='lessen'>29</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGAV'>ITGAV</a></td><td>ITGAV</td><td></td><td></td><td>10370</td><td>0.001</td><td>-0.0583</td><td>No</td></tr><tr><td class='lessen'>30</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TJP2'>TJP2</a></td><td>TJP2</td><td></td><td></td><td>10381</td><td>0.001</td><td>-0.0584</td><td>No</td></tr><tr><td class='lessen'>31</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LAMB3'>LAMB3</a></td><td>LAMB3</td><td></td><td></td><td>10602</td><td>0.000</td><td>-0.0685</td><td>No</td></tr><tr><td class='lessen'>32</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LPXN'>LPXN</a></td><td>LPXN</td><td></td><td></td><td>10613</td><td>0.000</td><td>-0.0689</td><td>No</td></tr><tr><td class='lessen'>33</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=SMAD3'>SMAD3</a></td><td>SMAD3</td><td></td><td></td><td>10809</td><td>-0.000</td><td>-0.0778</td><td>No</td></tr><tr><td class='lessen'>34</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=CLDN7'>CLDN7</a></td><td>CLDN7</td><td></td><td></td><td>11193</td><td>-0.002</td><td>-0.0948</td><td>No</td></tr><tr><td class='lessen'>35</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LAMA3'>LAMA3</a></td><td>LAMA3</td><td></td><td></td><td>11880</td><td>-0.004</td><td>-0.1249</td><td>No</td></tr><tr><td class='lessen'>36</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TJP3'>TJP3</a></td><td>TJP3</td><td></td><td></td><td>12607</td><td>-0.007</td><td>-0.1557</td><td>No</td></tr><tr><td class='lessen'>37</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGBL1'>ITGBL1</a></td><td>ITGBL1</td><td></td><td></td><td>12642</td><td>-0.007</td><td>-0.1544</td><td>No</td></tr><tr><td class='lessen'>38</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=WNT5A'>WNT5A</a></td><td>WNT5A</td><td></td><td></td><td>13222</td><td>-0.009</td><td>-0.1775</td><td>No</td></tr><tr><td class='lessen'>39</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGA6'>ITGA6</a></td><td>ITGA6</td><td></td><td></td><td>13656</td><td>-0.011</td><td>-0.1931</td><td>No</td></tr><tr><td class='lessen'>40</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGB2'>ITGB2</a></td><td>ITGB2</td><td></td><td></td><td>14233</td><td>-0.013</td><td>-0.2145</td><td>No</td></tr><tr><td class='lessen'>41</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=CD109'>CD109</a></td><td>CD109</td><td></td><td></td><td>14879</td><td>-0.016</td><td>-0.2379</td><td>No</td></tr><tr><td class='lessen'>42</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=BMP4'>BMP4</a></td><td>BMP4</td><td></td><td></td><td>14958</td><td>-0.016</td><td>-0.2349</td><td>No</td></tr><tr><td class='lessen'>43</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TNC'>TNC</a></td><td>TNC</td><td></td><td></td><td>16569</td><td>-0.023</td><td>-0.3000</td><td>No</td></tr><tr><td class='lessen'>44</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=PCDHB9'>PCDHB9</a></td><td>PCDHB9</td><td></td><td></td><td>16955</td><td>-0.025</td><td>-0.3074</td><td>No</td></tr><tr><td class='lessen'>45</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ROBO1'>ROBO1</a></td><td>ROBO1</td><td></td><td></td><td>17097</td><td>-0.026</td><td>-0.3031</td><td>No</td></tr><tr><td class='lessen'>46</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=RAB25'>RAB25</a></td><td>RAB25</td><td></td><td></td><td>17149</td><td>-0.026</td><td>-0.2946</td><td>No</td></tr><tr><td class='lessen'>47</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=TGFB2'>TGFB2</a></td><td>TGFB2</td><td></td><td></td><td>18238</td><td>-0.033</td><td>-0.3315</td><td>No</td></tr><tr><td class='lessen'>48</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=STAT5B'>STAT5B</a></td><td>STAT5B</td><td></td><td></td><td>18379</td><td>-0.033</td><td>-0.3239</td><td>No</td></tr><tr><td class='lessen'>49</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=NOG'>NOG</a></td><td>NOG</td><td></td><td></td><td>19054</td><td>-0.039</td><td>-0.3389</td><td>No</td></tr><tr><td class='lessen'>50</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=PLAUR'>PLAUR</a></td><td>PLAUR</td><td></td><td></td><td>19606</td><td>-0.045</td><td>-0.3457</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>51</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=CLDN4'>CLDN4</a></td><td>CLDN4</td><td></td><td></td><td>20006</td><td>-0.050</td><td>-0.3434</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>52</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGA5'>ITGA5</a></td><td>ITGA5</td><td></td><td></td><td>20099</td><td>-0.051</td><td>-0.3262</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>53</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=RND3'>RND3</a></td><td>RND3</td><td></td><td></td><td>20239</td><td>-0.053</td><td>-0.3102</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>54</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=FBN1'>FBN1</a></td><td>FBN1</td><td></td><td></td><td>20442</td><td>-0.057</td><td>-0.2958</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>55</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=PDGFB'>PDGFB</a></td><td>PDGFB</td><td></td><td></td><td>20640</td><td>-0.062</td><td>-0.2791</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>56</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=MMP14'>MMP14</a></td><td>MMP14</td><td></td><td></td><td>20926</td><td>-0.070</td><td>-0.2630</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>57</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=SNAI2'>SNAI2</a></td><td>SNAI2</td><td></td><td></td><td>20975</td><td>-0.072</td><td>-0.2351</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>58</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=LEF1'>LEF1</a></td><td>LEF1</td><td></td><td></td><td>21441</td><td>-0.111</td><td>-0.2104</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>59</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=PLAU'>PLAU</a></td><td>PLAU</td><td></td><td></td><td>21507</td><td>-0.141</td><td>-0.1544</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>60</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=SERPINE1'>SERPINE1</a></td><td>SERPINE1</td><td></td><td></td><td>21554</td><td>-0.173</td><td>-0.0840</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>61</td><td><a href='https://www.affymetrix.com/LinkServlet?probeset=ITGA3'>ITGA3</a></td><td>ITGA3</td><td></td><td></td><td>21577</td><td>-0.205</td><td>0.0008</td><td bgcolor='#CCFFCC'>Yes</td></tr><caption class='table'>Table: GSEA details <a href='FOSL1_TARGETS.xls'>[plain text format]</a></caption></table></div><br><div class='image'><img name='FOSL1_TARGETS' src='FOSL1_TARGETS_31.png'><br><br><caption>Fig 2: FOSL1_TARGETS    <br> Blue-Pink O' Gram in the Space of the Analyzed GeneSet</caption></div><br><div class='image'><img name='gset_rnd_es_dist' src='gset_rnd_es_dist_32.png'><br><br><caption>Fig 3: FOSL1_TARGETS: Random ES distribution    <br> Gene set null distribution of ES for <b>FOSL1_TARGETS</b></caption></div><br></body></html>