<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/1999/REC-html401-19991224/loose.dtd"> <html><head><title>Details for gene set NEFTEL_MES1_2019[GSEA]</title><link href='xtools.css' rel='stylesheet'><link href='http://www.gsea-msigdb.org/gsea/images/icon_16x16.png' rel='shortcut icon'></head><body><div class='keyValTable'><table cols='2' border='0'><th class='keyValTable'></th><th class='keyValTable'></th><tr><td>Dataset</td><td>NF1_GRD_exprs.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl_repos</td></tr><tr><td>Phenotype</td><td>NF1_GRD_phenotype.cls#GRD_versus_Ctrl_repos</td></tr><tr><td>Upregulated in class</td><td>Ctrl</td></tr><tr><td>GeneSet</td><td>NEFTEL_MES1_2019</td></tr><tr><td>Enrichment Score (ES)</td><td>-0.4376462</td></tr><tr><td>Normalized Enrichment Score (NES)</td><td>-1.6074172</td></tr><tr><td>Nominal p-value</td><td>0.009940358</td></tr><tr><td>FDR q-value</td><td>0.00918006</td></tr><tr><td>FWER p-Value</td><td>0.071</td></tr><caption class='table'>Table: GSEA Results Summary</caption></table></div><br><div class='image'><img name='enplot_NEFTEL_MES1_2019' src='enplot_NEFTEL_MES1_2019_173.png'><br><br><caption>Fig 1: Enrichment plot: NEFTEL_MES1_2019    <br> Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List</caption></div><br><div class='richTable'><table cols='7' border='1'><th class='richTable'></th><th class='richTable'>SYMBOL</th><th class='richTable'>TITLE</th><th class='richTable'>RANK IN GENE LIST</th><th class='richTable'>RANK METRIC SCORE</th><th class='richTable'>RUNNING ES</th><th class='richTable'>CORE ENRICHMENT</th><tr><td class='lessen'>1</td><td><a href='https://ensembl.org/Search/Results?q=A2M'>A2M</a></td><td>A2M</td><td>36</td><td>0.168</td><td>0.0513</td><td>No</td></tr><tr><td class='lessen'>2</td><td><a href='https://ensembl.org/Search/Results?q=ANXA2'>ANXA2</a></td><td>ANXA2</td><td>41</td><td>0.164</td><td>0.1028</td><td>No</td></tr><tr><td class='lessen'>3</td><td><a href='https://ensembl.org/Search/Results?q=ANXA1'>ANXA1</a></td><td>ANXA1</td><td>87</td><td>0.133</td><td>0.1428</td><td>No</td></tr><tr><td class='lessen'>4</td><td><a href='https://ensembl.org/Search/Results?q=C1R'>C1R</a></td><td>C1R</td><td>108</td><td>0.120</td><td>0.1798</td><td>No</td></tr><tr><td class='lessen'>5</td><td><a href='https://ensembl.org/Search/Results?q=C1S'>C1S</a></td><td>C1S</td><td>115</td><td>0.117</td><td>0.2164</td><td>No</td></tr><tr><td class='lessen'>6</td><td><a href='https://ensembl.org/Search/Results?q=CD44'>CD44</a></td><td>CD44</td><td>281</td><td>0.092</td><td>0.2377</td><td>No</td></tr><tr><td class='lessen'>7</td><td><a href='https://ensembl.org/Search/Results?q=NAMPT'>NAMPT</a></td><td>NAMPT</td><td>433</td><td>0.081</td><td>0.2562</td><td>No</td></tr><tr><td class='lessen'>8</td><td><a href='https://ensembl.org/Search/Results?q=GSN'>GSN</a></td><td>GSN</td><td>1394</td><td>0.053</td><td>0.2283</td><td>No</td></tr><tr><td class='lessen'>9</td><td><a href='https://ensembl.org/Search/Results?q=VIM'>VIM</a></td><td>VIM</td><td>1546</td><td>0.051</td><td>0.2372</td><td>No</td></tr><tr><td class='lessen'>10</td><td><a href='https://ensembl.org/Search/Results?q=SOD2'>SOD2</a></td><td>SOD2</td><td>1797</td><td>0.047</td><td>0.2405</td><td>No</td></tr><tr><td class='lessen'>11</td><td><a href='https://ensembl.org/Search/Results?q=LGALS3'>LGALS3</a></td><td>LGALS3</td><td>2318</td><td>0.041</td><td>0.2293</td><td>No</td></tr><tr><td class='lessen'>12</td><td><a href='https://ensembl.org/Search/Results?q=PRDX6'>PRDX6</a></td><td>PRDX6</td><td>2615</td><td>0.038</td><td>0.2277</td><td>No</td></tr><tr><td class='lessen'>13</td><td><a href='https://ensembl.org/Search/Results?q=S100A10'>S100A10</a></td><td>S100A10</td><td>3782</td><td>0.030</td><td>0.1829</td><td>No</td></tr><tr><td class='lessen'>14</td><td><a href='https://ensembl.org/Search/Results?q=GJA1'>GJA1</a></td><td>GJA1</td><td>4600</td><td>0.025</td><td>0.1527</td><td>No</td></tr><tr><td class='lessen'>15</td><td><a href='https://ensembl.org/Search/Results?q=TUBA1C'>TUBA1C</a></td><td>TUBA1C</td><td>4861</td><td>0.023</td><td>0.1480</td><td>No</td></tr><tr><td class='lessen'>16</td><td><a href='https://ensembl.org/Search/Results?q=SERPING1'>SERPING1</a></td><td>SERPING1</td><td>5211</td><td>0.021</td><td>0.1386</td><td>No</td></tr><tr><td class='lessen'>17</td><td><a href='https://ensembl.org/Search/Results?q=FN1'>FN1</a></td><td>FN1</td><td>7138</td><td>0.013</td><td>0.0532</td><td>No</td></tr><tr><td class='lessen'>18</td><td><a href='https://ensembl.org/Search/Results?q=SERPINA3'>SERPINA3</a></td><td>SERPINA3</td><td>10080</td><td>0.002</td><td>-0.0826</td><td>No</td></tr><tr><td class='lessen'>19</td><td><a href='https://ensembl.org/Search/Results?q=MGP'>MGP</a></td><td>MGP</td><td>10231</td><td>0.002</td><td>-0.0891</td><td>No</td></tr><tr><td class='lessen'>20</td><td><a href='https://ensembl.org/Search/Results?q=TNFRSF1A'>TNFRSF1A</a></td><td>TNFRSF1A</td><td>11380</td><td>-0.003</td><td>-0.1416</td><td>No</td></tr><tr><td class='lessen'>21</td><td><a href='https://ensembl.org/Search/Results?q=EFEMP1'>EFEMP1</a></td><td>EFEMP1</td><td>11470</td><td>-0.003</td><td>-0.1448</td><td>No</td></tr><tr><td class='lessen'>22</td><td><a href='https://ensembl.org/Search/Results?q=LGALS1'>LGALS1</a></td><td>LGALS1</td><td>12490</td><td>-0.006</td><td>-0.1901</td><td>No</td></tr><tr><td class='lessen'>23</td><td><a href='https://ensembl.org/Search/Results?q=WWTR1'>WWTR1</a></td><td>WWTR1</td><td>12641</td><td>-0.007</td><td>-0.1949</td><td>No</td></tr><tr><td class='lessen'>24</td><td><a href='https://ensembl.org/Search/Results?q=ACTN1'>ACTN1</a></td><td>ACTN1</td><td>13245</td><td>-0.009</td><td>-0.2200</td><td>No</td></tr><tr><td class='lessen'>25</td><td><a href='https://ensembl.org/Search/Results?q=NPC2'>NPC2</a></td><td>NPC2</td><td>14183</td><td>-0.013</td><td>-0.2594</td><td>No</td></tr><tr><td class='lessen'>26</td><td><a href='https://ensembl.org/Search/Results?q=C8orf4'>C8orf4</a></td><td>C8orf4</td><td>14431</td><td>-0.014</td><td>-0.2666</td><td>No</td></tr><tr><td class='lessen'>27</td><td><a href='https://ensembl.org/Search/Results?q=NNMT'>NNMT</a></td><td>NNMT</td><td>16336</td><td>-0.022</td><td>-0.3480</td><td>No</td></tr><tr><td class='lessen'>28</td><td><a href='https://ensembl.org/Search/Results?q=RCAN1'>RCAN1</a></td><td>RCAN1</td><td>16375</td><td>-0.022</td><td>-0.3428</td><td>No</td></tr><tr><td class='lessen'>29</td><td><a href='https://ensembl.org/Search/Results?q=MGST1'>MGST1</a></td><td>MGST1</td><td>17400</td><td>-0.027</td><td>-0.3816</td><td>No</td></tr><tr><td class='lessen'>30</td><td><a href='https://ensembl.org/Search/Results?q=CTSB'>CTSB</a></td><td>CTSB</td><td>18445</td><td>-0.034</td><td>-0.4193</td><td>No</td></tr><tr><td class='lessen'>31</td><td><a href='https://ensembl.org/Search/Results?q=GFPT2'>GFPT2</a></td><td>GFPT2</td><td>18731</td><td>-0.036</td><td>-0.4211</td><td>No</td></tr><tr><td class='lessen'>32</td><td><a href='https://ensembl.org/Search/Results?q=S100A16'>S100A16</a></td><td>S100A16</td><td>19089</td><td>-0.039</td><td>-0.4252</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>33</td><td><a href='https://ensembl.org/Search/Results?q=IFITM3'>IFITM3</a></td><td>IFITM3</td><td>19155</td><td>-0.040</td><td>-0.4155</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>34</td><td><a href='https://ensembl.org/Search/Results?q=IGFBP7'>IGFBP7</a></td><td>IGFBP7</td><td>19557</td><td>-0.044</td><td>-0.4202</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>35</td><td><a href='https://ensembl.org/Search/Results?q=TAGLN2'>TAGLN2</a></td><td>TAGLN2</td><td>19565</td><td>-0.044</td><td>-0.4065</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>36</td><td><a href='https://ensembl.org/Search/Results?q=EMP3'>EMP3</a></td><td>EMP3</td><td>19792</td><td>-0.047</td><td>-0.4022</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>37</td><td><a href='https://ensembl.org/Search/Results?q=C3'>C3</a></td><td>C3</td><td>20052</td><td>-0.051</td><td>-0.3982</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>38</td><td><a href='https://ensembl.org/Search/Results?q=CLIC1'>CLIC1</a></td><td>CLIC1</td><td>20260</td><td>-0.054</td><td>-0.3908</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>39</td><td><a href='https://ensembl.org/Search/Results?q=CLIC4'>CLIC4</a></td><td>CLIC4</td><td>20326</td><td>-0.055</td><td>-0.3764</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>40</td><td><a href='https://ensembl.org/Search/Results?q=MT2A'>MT2A</a></td><td>MT2A</td><td>20689</td><td>-0.063</td><td>-0.3732</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>41</td><td><a href='https://ensembl.org/Search/Results?q=TIMP1'>TIMP1</a></td><td>TIMP1</td><td>21029</td><td>-0.074</td><td>-0.3657</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>42</td><td><a href='https://ensembl.org/Search/Results?q=S100A11'>S100A11</a></td><td>S100A11</td><td>21047</td><td>-0.075</td><td>-0.3429</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>43</td><td><a href='https://ensembl.org/Search/Results?q=PLP2'>PLP2</a></td><td>PLP2</td><td>21203</td><td>-0.083</td><td>-0.3238</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>44</td><td><a href='https://ensembl.org/Search/Results?q=MT1X'>MT1X</a></td><td>MT1X</td><td>21257</td><td>-0.087</td><td>-0.2987</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>45</td><td><a href='https://ensembl.org/Search/Results?q=MT1E'>MT1E</a></td><td>MT1E</td><td>21261</td><td>-0.087</td><td>-0.2712</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>46</td><td><a href='https://ensembl.org/Search/Results?q=SPP1'>SPP1</a></td><td>SPP1</td><td>21488</td><td>-0.124</td><td>-0.2424</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>47</td><td><a href='https://ensembl.org/Search/Results?q=EMP1'>EMP1</a></td><td>EMP1</td><td>21515</td><td>-0.145</td><td>-0.1980</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>48</td><td><a href='https://ensembl.org/Search/Results?q=SERPINE1'>SERPINE1</a></td><td>SERPINE1</td><td>21554</td><td>-0.173</td><td>-0.1451</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>49</td><td><a href='https://ensembl.org/Search/Results?q=CHI3L1'>CHI3L1</a></td><td>CHI3L1</td><td>21572</td><td>-0.194</td><td>-0.0847</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>50</td><td><a href='https://ensembl.org/Search/Results?q=APOE'>APOE</a></td><td>APOE</td><td>21593</td><td>-0.272</td><td>0.0001</td><td bgcolor='#CCFFCC'>Yes</td></tr><caption class='table'>Table: GSEA details <a href='NEFTEL_MES1_2019.tsv'>[plain text format]</a></caption></table></div><br><div class='image'><img name='NEFTEL_MES1_2019' src='NEFTEL_MES1_2019_174.png'><br><br><caption>Fig 2: NEFTEL_MES1_2019    <br> Blue-Pink O' Gram in the Space of the Analyzed GeneSet</caption></div><br><div class='image'><img name='gset_rnd_es_dist' src='gset_rnd_es_dist_175.png'><br><br><caption>Fig 3: NEFTEL_MES1_2019: Random ES distribution    <br> Gene set null distribution of ES for <b>NEFTEL_MES1_2019</b></caption></div><br></body></html>