<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/1999/REC-html401-19991224/loose.dtd"> <html><head><title>Details for gene set NEFTEL_MES2_2019[GSEA]</title><link href='xtools.css' rel='stylesheet'><link href='http://www.gsea-msigdb.org/gsea/images/icon_16x16.png' rel='shortcut icon'></head><body><div class='keyValTable'><table cols='2' border='0'><th class='keyValTable'></th><th class='keyValTable'></th><tr><td>Dataset</td><td>NF1_GRD_exprs.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl_repos</td></tr><tr><td>Phenotype</td><td>NF1_GRD_phenotype.cls#GRD_versus_Ctrl_repos</td></tr><tr><td>Upregulated in class</td><td>GRD</td></tr><tr><td>GeneSet</td><td>NEFTEL_MES2_2019</td></tr><tr><td>Enrichment Score (ES)</td><td>0.473447</td></tr><tr><td>Normalized Enrichment Score (NES)</td><td>1.6622528</td></tr><tr><td>Nominal p-value</td><td>0.004149378</td></tr><tr><td>FDR q-value</td><td>0.008401492</td></tr><tr><td>FWER p-Value</td><td>0.043</td></tr><caption class='table'>Table: GSEA Results Summary</caption></table></div><br><div class='image'><img name='enplot_NEFTEL_MES2_2019' src='enplot_NEFTEL_MES2_2019_116.png'><br><br><caption>Fig 1: Enrichment plot: NEFTEL_MES2_2019    <br> Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List</caption></div><br><div class='richTable'><table cols='7' border='1'><th class='richTable'></th><th class='richTable'>SYMBOL</th><th class='richTable'>TITLE</th><th class='richTable'>RANK IN GENE LIST</th><th class='richTable'>RANK METRIC SCORE</th><th class='richTable'>RUNNING ES</th><th class='richTable'>CORE ENRICHMENT</th><tr><td class='lessen'>1</td><td><a href='https://ensembl.org/Search/Results?q=ANXA2'>ANXA2</a></td><td>ANXA2</td><td>41</td><td>0.164</td><td>0.0461</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>2</td><td><a href='https://ensembl.org/Search/Results?q=BNIP3L'>BNIP3L</a></td><td>BNIP3L</td><td>60</td><td>0.144</td><td>0.0876</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>3</td><td><a href='https://ensembl.org/Search/Results?q=ERO1L'>ERO1L</a></td><td>ERO1L</td><td>70</td><td>0.140</td><td>0.1285</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>4</td><td><a href='https://ensembl.org/Search/Results?q=P4HA1'>P4HA1</a></td><td>P4HA1</td><td>80</td><td>0.135</td><td>0.1677</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>5</td><td><a href='https://ensembl.org/Search/Results?q=SLC6A6'>SLC6A6</a></td><td>SLC6A6</td><td>113</td><td>0.117</td><td>0.2006</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>6</td><td><a href='https://ensembl.org/Search/Results?q=INSIG2'>INSIG2</a></td><td>INSIG2</td><td>152</td><td>0.107</td><td>0.2304</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>7</td><td><a href='https://ensembl.org/Search/Results?q=PLOD2'>PLOD2</a></td><td>PLOD2</td><td>157</td><td>0.107</td><td>0.2616</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>8</td><td><a href='https://ensembl.org/Search/Results?q=CA9'>CA9</a></td><td>CA9</td><td>191</td><td>0.101</td><td>0.2898</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>9</td><td><a href='https://ensembl.org/Search/Results?q=ENO2'>ENO2</a></td><td>ENO2</td><td>222</td><td>0.097</td><td>0.3168</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>10</td><td><a href='https://ensembl.org/Search/Results?q=NAMPT'>NAMPT</a></td><td>NAMPT</td><td>433</td><td>0.081</td><td>0.3308</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>11</td><td><a href='https://ensembl.org/Search/Results?q=PPP1R15A'>PPP1R15A</a></td><td>PPP1R15A</td><td>477</td><td>0.079</td><td>0.3519</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>12</td><td><a href='https://ensembl.org/Search/Results?q=ADM'>ADM</a></td><td>ADM</td><td>533</td><td>0.076</td><td>0.3718</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>13</td><td><a href='https://ensembl.org/Search/Results?q=SLC2A1'>SLC2A1</a></td><td>SLC2A1</td><td>541</td><td>0.076</td><td>0.3937</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>14</td><td><a href='https://ensembl.org/Search/Results?q=BNIP3'>BNIP3</a></td><td>BNIP3</td><td>620</td><td>0.072</td><td>0.4112</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>15</td><td><a href='https://ensembl.org/Search/Results?q=PGK1'>PGK1</a></td><td>PGK1</td><td>897</td><td>0.063</td><td>0.4169</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>16</td><td><a href='https://ensembl.org/Search/Results?q=SLC2A3'>SLC2A3</a></td><td>SLC2A3</td><td>977</td><td>0.061</td><td>0.4312</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>17</td><td><a href='https://ensembl.org/Search/Results?q=ANGPTL4'>ANGPTL4</a></td><td>ANGPTL4</td><td>1289</td><td>0.055</td><td>0.4328</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>18</td><td><a href='https://ensembl.org/Search/Results?q=VIM'>VIM</a></td><td>VIM</td><td>1546</td><td>0.051</td><td>0.4358</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>19</td><td><a href='https://ensembl.org/Search/Results?q=AKAP12'>AKAP12</a></td><td>AKAP12</td><td>1567</td><td>0.050</td><td>0.4496</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>20</td><td><a href='https://ensembl.org/Search/Results?q=UFM1'>UFM1</a></td><td>UFM1</td><td>1675</td><td>0.049</td><td>0.4590</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>21</td><td><a href='https://ensembl.org/Search/Results?q=EPAS1'>EPAS1</a></td><td>EPAS1</td><td>1753</td><td>0.048</td><td>0.4694</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>22</td><td><a href='https://ensembl.org/Search/Results?q=DNAJB9'>DNAJB9</a></td><td>DNAJB9</td><td>1954</td><td>0.045</td><td>0.4734</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>23</td><td><a href='https://ensembl.org/Search/Results?q=LGALS3'>LGALS3</a></td><td>LGALS3</td><td>2318</td><td>0.041</td><td>0.4686</td><td>No</td></tr><tr><td class='lessen'>24</td><td><a href='https://ensembl.org/Search/Results?q=EGLN3'>EGLN3</a></td><td>EGLN3</td><td>2526</td><td>0.039</td><td>0.4705</td><td>No</td></tr><tr><td class='lessen'>25</td><td><a href='https://ensembl.org/Search/Results?q=GBE1'>GBE1</a></td><td>GBE1</td><td>2760</td><td>0.037</td><td>0.4706</td><td>No</td></tr><tr><td class='lessen'>26</td><td><a href='https://ensembl.org/Search/Results?q=PFKP'>PFKP</a></td><td>PFKP</td><td>3701</td><td>0.030</td><td>0.4359</td><td>No</td></tr><tr><td class='lessen'>27</td><td><a href='https://ensembl.org/Search/Results?q=XPOT'>XPOT</a></td><td>XPOT</td><td>4630</td><td>0.024</td><td>0.4000</td><td>No</td></tr><tr><td class='lessen'>28</td><td><a href='https://ensembl.org/Search/Results?q=LDHA'>LDHA</a></td><td>LDHA</td><td>5202</td><td>0.022</td><td>0.3798</td><td>No</td></tr><tr><td class='lessen'>29</td><td><a href='https://ensembl.org/Search/Results?q=NRN1'>NRN1</a></td><td>NRN1</td><td>6540</td><td>0.015</td><td>0.3223</td><td>No</td></tr><tr><td class='lessen'>30</td><td><a href='https://ensembl.org/Search/Results?q=HSPA5'>HSPA5</a></td><td>HSPA5</td><td>9422</td><td>0.004</td><td>0.1899</td><td>No</td></tr><tr><td class='lessen'>31</td><td><a href='https://ensembl.org/Search/Results?q=FTL'>FTL</a></td><td>FTL</td><td>9543</td><td>0.004</td><td>0.1855</td><td>No</td></tr><tr><td class='lessen'>32</td><td><a href='https://ensembl.org/Search/Results?q=SLC39A14'>SLC39A14</a></td><td>SLC39A14</td><td>10792</td><td>-0.000</td><td>0.1277</td><td>No</td></tr><tr><td class='lessen'>33</td><td><a href='https://ensembl.org/Search/Results?q=ATF3'>ATF3</a></td><td>ATF3</td><td>11356</td><td>-0.002</td><td>0.1023</td><td>No</td></tr><tr><td class='lessen'>34</td><td><a href='https://ensembl.org/Search/Results?q=GOLT1B'>GOLT1B</a></td><td>GOLT1B</td><td>11639</td><td>-0.003</td><td>0.0902</td><td>No</td></tr><tr><td class='lessen'>35</td><td><a href='https://ensembl.org/Search/Results?q=TRAM1'>TRAM1</a></td><td>TRAM1</td><td>13353</td><td>-0.010</td><td>0.0135</td><td>No</td></tr><tr><td class='lessen'>36</td><td><a href='https://ensembl.org/Search/Results?q=HERPUD1'>HERPUD1</a></td><td>HERPUD1</td><td>14200</td><td>-0.013</td><td>-0.0220</td><td>No</td></tr><tr><td class='lessen'>37</td><td><a href='https://ensembl.org/Search/Results?q=HSPA9'>HSPA9</a></td><td>HSPA9</td><td>16238</td><td>-0.022</td><td>-0.1102</td><td>No</td></tr><tr><td class='lessen'>38</td><td><a href='https://ensembl.org/Search/Results?q=RPL21'>RPL21</a></td><td>RPL21</td><td>17015</td><td>-0.025</td><td>-0.1388</td><td>No</td></tr><tr><td class='lessen'>39</td><td><a href='https://ensembl.org/Search/Results?q=IGFBP3'>IGFBP3</a></td><td>IGFBP3</td><td>19998</td><td>-0.050</td><td>-0.2625</td><td>No</td></tr><tr><td class='lessen'>40</td><td><a href='https://ensembl.org/Search/Results?q=SQSTM1'>SQSTM1</a></td><td>SQSTM1</td><td>20653</td><td>-0.062</td><td>-0.2747</td><td>No</td></tr><tr><td class='lessen'>41</td><td><a href='https://ensembl.org/Search/Results?q=DDIT3'>DDIT3</a></td><td>DDIT3</td><td>20728</td><td>-0.064</td><td>-0.2593</td><td>No</td></tr><tr><td class='lessen'>42</td><td><a href='https://ensembl.org/Search/Results?q=ASNS'>ASNS</a></td><td>ASNS</td><td>20893</td><td>-0.069</td><td>-0.2465</td><td>No</td></tr><tr><td class='lessen'>43</td><td><a href='https://ensembl.org/Search/Results?q=CDKN1A'>CDKN1A</a></td><td>CDKN1A</td><td>20989</td><td>-0.072</td><td>-0.2297</td><td>No</td></tr><tr><td class='lessen'>44</td><td><a href='https://ensembl.org/Search/Results?q=SERTAD1'>SERTAD1</a></td><td>SERTAD1</td><td>21172</td><td>-0.081</td><td>-0.2142</td><td>No</td></tr><tr><td class='lessen'>45</td><td><a href='https://ensembl.org/Search/Results?q=MT1X'>MT1X</a></td><td>MT1X</td><td>21257</td><td>-0.087</td><td>-0.1925</td><td>No</td></tr><tr><td class='lessen'>46</td><td><a href='https://ensembl.org/Search/Results?q=WARS'>WARS</a></td><td>WARS</td><td>21449</td><td>-0.112</td><td>-0.1684</td><td>No</td></tr><tr><td class='lessen'>47</td><td><a href='https://ensembl.org/Search/Results?q=NDRG1'>NDRG1</a></td><td>NDRG1</td><td>21524</td><td>-0.149</td><td>-0.1280</td><td>No</td></tr><tr><td class='lessen'>48</td><td><a href='https://ensembl.org/Search/Results?q=TRIB3'>TRIB3</a></td><td>TRIB3</td><td>21564</td><td>-0.183</td><td>-0.0760</td><td>No</td></tr><tr><td class='lessen'>49</td><td><a href='https://ensembl.org/Search/Results?q=GDF15'>GDF15</a></td><td>GDF15</td><td>21592</td><td>-0.263</td><td>0.0001</td><td>No</td></tr><caption class='table'>Table: GSEA details <a href='NEFTEL_MES2_2019.tsv'>[plain text format]</a></caption></table></div><br><div class='image'><img name='NEFTEL_MES2_2019' src='NEFTEL_MES2_2019_117.png'><br><br><caption>Fig 2: NEFTEL_MES2_2019    <br> Blue-Pink O' Gram in the Space of the Analyzed GeneSet</caption></div><br><div class='image'><img name='gset_rnd_es_dist' src='gset_rnd_es_dist_118.png'><br><br><caption>Fig 3: NEFTEL_MES2_2019: Random ES distribution    <br> Gene set null distribution of ES for <b>NEFTEL_MES2_2019</b></caption></div><br></body></html>