<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/1999/REC-html401-19991224/loose.dtd"> <html><head><title>Details for gene set WANG_MES_2017[GSEA]</title><link href='xtools.css' rel='stylesheet'><link href='http://www.gsea-msigdb.org/gsea/images/icon_16x16.png' rel='shortcut icon'></head><body><div class='keyValTable'><table cols='2' border='0'><th class='keyValTable'></th><th class='keyValTable'></th><tr><td>Dataset</td><td>NF1_GRD_exprs.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl.NF1_GRD_phenotype.cls<br>#GRD_versus_Ctrl_repos</td></tr><tr><td>Phenotype</td><td>NF1_GRD_phenotype.cls#GRD_versus_Ctrl_repos</td></tr><tr><td>Upregulated in class</td><td>Ctrl</td></tr><tr><td>GeneSet</td><td>WANG_MES_2017</td></tr><tr><td>Enrichment Score (ES)</td><td>-0.3735108</td></tr><tr><td>Normalized Enrichment Score (NES)</td><td>-1.3397602</td></tr><tr><td>Nominal p-value</td><td>0.0831643</td></tr><tr><td>FDR q-value</td><td>0.063794345</td></tr><tr><td>FWER p-Value</td><td>0.543</td></tr><caption class='table'>Table: GSEA Results Summary</caption></table></div><br><div class='image'><img name='enplot_WANG_MES_2017' src='enplot_WANG_MES_2017_185.png'><br><br><caption>Fig 1: Enrichment plot: WANG_MES_2017    <br> Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List</caption></div><br><div class='richTable'><table cols='7' border='1'><th class='richTable'></th><th class='richTable'>SYMBOL</th><th class='richTable'>TITLE</th><th class='richTable'>RANK IN GENE LIST</th><th class='richTable'>RANK METRIC SCORE</th><th class='richTable'>RUNNING ES</th><th class='richTable'>CORE ENRICHMENT</th><tr><td class='lessen'>1</td><td><a href='https://ensembl.org/Search/Results?q=TGFBI'>TGFBI</a></td><td>TGFBI</td><td>137</td><td>0.111</td><td>0.0555</td><td>No</td></tr><tr><td class='lessen'>2</td><td><a href='https://ensembl.org/Search/Results?q=ITGB1'>ITGB1</a></td><td>ITGB1</td><td>677</td><td>0.070</td><td>0.0699</td><td>No</td></tr><tr><td class='lessen'>3</td><td><a href='https://ensembl.org/Search/Results?q=COL5A1'>COL5A1</a></td><td>COL5A1</td><td>1392</td><td>0.053</td><td>0.0663</td><td>No</td></tr><tr><td class='lessen'>4</td><td><a href='https://ensembl.org/Search/Results?q=CNN2'>CNN2</a></td><td>CNN2</td><td>2016</td><td>0.045</td><td>0.0623</td><td>No</td></tr><tr><td class='lessen'>5</td><td><a href='https://ensembl.org/Search/Results?q=GPRC5A'>GPRC5A</a></td><td>GPRC5A</td><td>2052</td><td>0.044</td><td>0.0854</td><td>No</td></tr><tr><td class='lessen'>6</td><td><a href='https://ensembl.org/Search/Results?q=RGS2'>RGS2</a></td><td>RGS2</td><td>2154</td><td>0.043</td><td>0.1048</td><td>No</td></tr><tr><td class='lessen'>7</td><td><a href='https://ensembl.org/Search/Results?q=BCL3'>BCL3</a></td><td>BCL3</td><td>2307</td><td>0.041</td><td>0.1207</td><td>No</td></tr><tr><td class='lessen'>8</td><td><a href='https://ensembl.org/Search/Results?q=ANPEP'>ANPEP</a></td><td>ANPEP</td><td>2706</td><td>0.038</td><td>0.1234</td><td>No</td></tr><tr><td class='lessen'>9</td><td><a href='https://ensembl.org/Search/Results?q=COL3A1'>COL3A1</a></td><td>COL3A1</td><td>2743</td><td>0.037</td><td>0.1426</td><td>No</td></tr><tr><td class='lessen'>10</td><td><a href='https://ensembl.org/Search/Results?q=RARRES1'>RARRES1</a></td><td>RARRES1</td><td>3184</td><td>0.034</td><td>0.1411</td><td>No</td></tr><tr><td class='lessen'>11</td><td><a href='https://ensembl.org/Search/Results?q=SLPI'>SLPI</a></td><td>SLPI</td><td>3427</td><td>0.032</td><td>0.1478</td><td>No</td></tr><tr><td class='lessen'>12</td><td><a href='https://ensembl.org/Search/Results?q=BACE2'>BACE2</a></td><td>BACE2</td><td>3897</td><td>0.029</td><td>0.1422</td><td>No</td></tr><tr><td class='lessen'>13</td><td><a href='https://ensembl.org/Search/Results?q=TNFAIP8'>TNFAIP8</a></td><td>TNFAIP8</td><td>4128</td><td>0.027</td><td>0.1469</td><td>No</td></tr><tr><td class='lessen'>14</td><td><a href='https://ensembl.org/Search/Results?q=LOX'>LOX</a></td><td>LOX</td><td>5014</td><td>0.022</td><td>0.1184</td><td>No</td></tr><tr><td class='lessen'>15</td><td><a href='https://ensembl.org/Search/Results?q=GLIPR1'>GLIPR1</a></td><td>GLIPR1</td><td>8258</td><td>0.009</td><td>-0.0273</td><td>No</td></tr><tr><td class='lessen'>16</td><td><a href='https://ensembl.org/Search/Results?q=MMP7'>MMP7</a></td><td>MMP7</td><td>9129</td><td>0.006</td><td>-0.0646</td><td>No</td></tr><tr><td class='lessen'>17</td><td><a href='https://ensembl.org/Search/Results?q=CDCP1'>CDCP1</a></td><td>CDCP1</td><td>9398</td><td>0.005</td><td>-0.0745</td><td>No</td></tr><tr><td class='lessen'>18</td><td><a href='https://ensembl.org/Search/Results?q=RAC2'>RAC2</a></td><td>RAC2</td><td>9455</td><td>0.004</td><td>-0.0746</td><td>No</td></tr><tr><td class='lessen'>19</td><td><a href='https://ensembl.org/Search/Results?q=FTL'>FTL</a></td><td>FTL</td><td>9543</td><td>0.004</td><td>-0.0765</td><td>No</td></tr><tr><td class='lessen'>20</td><td><a href='https://ensembl.org/Search/Results?q=COL1A2'>COL1A2</a></td><td>COL1A2</td><td>9939</td><td>0.003</td><td>-0.0934</td><td>No</td></tr><tr><td class='lessen'>21</td><td><a href='https://ensembl.org/Search/Results?q=THBS1'>THBS1</a></td><td>THBS1</td><td>10919</td><td>-0.001</td><td>-0.1384</td><td>No</td></tr><tr><td class='lessen'>22</td><td><a href='https://ensembl.org/Search/Results?q=ACPP'>ACPP</a></td><td>ACPP</td><td>10996</td><td>-0.001</td><td>-0.1413</td><td>No</td></tr><tr><td class='lessen'>23</td><td><a href='https://ensembl.org/Search/Results?q=IL6'>IL6</a></td><td>IL6</td><td>11217</td><td>-0.002</td><td>-0.1504</td><td>No</td></tr><tr><td class='lessen'>24</td><td><a href='https://ensembl.org/Search/Results?q=CD72'>CD72</a></td><td>CD72</td><td>11460</td><td>-0.003</td><td>-0.1601</td><td>No</td></tr><tr><td class='lessen'>25</td><td><a href='https://ensembl.org/Search/Results?q=RUNX1'>RUNX1</a></td><td>RUNX1</td><td>11533</td><td>-0.003</td><td>-0.1617</td><td>No</td></tr><tr><td class='lessen'>26</td><td><a href='https://ensembl.org/Search/Results?q=COL15A1'>COL15A1</a></td><td>COL15A1</td><td>12559</td><td>-0.007</td><td>-0.2056</td><td>No</td></tr><tr><td class='lessen'>27</td><td><a href='https://ensembl.org/Search/Results?q=RAB27A'>RAB27A</a></td><td>RAB27A</td><td>12626</td><td>-0.007</td><td>-0.2048</td><td>No</td></tr><tr><td class='lessen'>28</td><td><a href='https://ensembl.org/Search/Results?q=PTGS2'>PTGS2</a></td><td>PTGS2</td><td>13295</td><td>-0.009</td><td>-0.2306</td><td>No</td></tr><tr><td class='lessen'>29</td><td><a href='https://ensembl.org/Search/Results?q=PI3'>PI3</a></td><td>PI3</td><td>13838</td><td>-0.011</td><td>-0.2493</td><td>No</td></tr><tr><td class='lessen'>30</td><td><a href='https://ensembl.org/Search/Results?q=CAV1'>CAV1</a></td><td>CAV1</td><td>14427</td><td>-0.014</td><td>-0.2690</td><td>No</td></tr><tr><td class='lessen'>31</td><td><a href='https://ensembl.org/Search/Results?q=BNC2'>BNC2</a></td><td>BNC2</td><td>14603</td><td>-0.014</td><td>-0.2690</td><td>No</td></tr><tr><td class='lessen'>32</td><td><a href='https://ensembl.org/Search/Results?q=COL1A1'>COL1A1</a></td><td>COL1A1</td><td>14878</td><td>-0.016</td><td>-0.2731</td><td>No</td></tr><tr><td class='lessen'>33</td><td><a href='https://ensembl.org/Search/Results?q=LUM'>LUM</a></td><td>LUM</td><td>15213</td><td>-0.017</td><td>-0.2791</td><td>No</td></tr><tr><td class='lessen'>34</td><td><a href='https://ensembl.org/Search/Results?q=SPAG4'>SPAG4</a></td><td>SPAG4</td><td>15315</td><td>-0.017</td><td>-0.2741</td><td>No</td></tr><tr><td class='lessen'>35</td><td><a href='https://ensembl.org/Search/Results?q=VDR'>VDR</a></td><td>VDR</td><td>15499</td><td>-0.018</td><td>-0.2724</td><td>No</td></tr><tr><td class='lessen'>36</td><td><a href='https://ensembl.org/Search/Results?q=NNMT'>NNMT</a></td><td>NNMT</td><td>16336</td><td>-0.022</td><td>-0.2989</td><td>No</td></tr><tr><td class='lessen'>37</td><td><a href='https://ensembl.org/Search/Results?q=IL7R'>IL7R</a></td><td>IL7R</td><td>17107</td><td>-0.026</td><td>-0.3202</td><td>No</td></tr><tr><td class='lessen'>38</td><td><a href='https://ensembl.org/Search/Results?q=SYNGR2'>SYNGR2</a></td><td>SYNGR2</td><td>17709</td><td>-0.029</td><td>-0.3317</td><td>No</td></tr><tr><td class='lessen'>39</td><td><a href='https://ensembl.org/Search/Results?q=CTSB'>CTSB</a></td><td>CTSB</td><td>18445</td><td>-0.034</td><td>-0.3467</td><td>No</td></tr><tr><td class='lessen'>40</td><td><a href='https://ensembl.org/Search/Results?q=SDC1'>SDC1</a></td><td>SDC1</td><td>18831</td><td>-0.037</td><td>-0.3438</td><td>No</td></tr><tr><td class='lessen'>41</td><td><a href='https://ensembl.org/Search/Results?q=P4HA2'>P4HA2</a></td><td>P4HA2</td><td>19472</td><td>-0.043</td><td>-0.3493</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>42</td><td><a href='https://ensembl.org/Search/Results?q=PLAUR'>PLAUR</a></td><td>PLAUR</td><td>19606</td><td>-0.045</td><td>-0.3304</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>43</td><td><a href='https://ensembl.org/Search/Results?q=CTSC'>CTSC</a></td><td>CTSC</td><td>19916</td><td>-0.049</td><td>-0.3175</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>44</td><td><a href='https://ensembl.org/Search/Results?q=CYP1B1'>CYP1B1</a></td><td>CYP1B1</td><td>20518</td><td>-0.059</td><td>-0.3126</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>45</td><td><a href='https://ensembl.org/Search/Results?q=S100A11'>S100A11</a></td><td>S100A11</td><td>21047</td><td>-0.075</td><td>-0.2953</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>46</td><td><a href='https://ensembl.org/Search/Results?q=ARPC1B'>ARPC1B</a></td><td>ARPC1B</td><td>21177</td><td>-0.082</td><td>-0.2555</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>47</td><td><a href='https://ensembl.org/Search/Results?q=LY96'>LY96</a></td><td>LY96</td><td>21395</td><td>-0.104</td><td>-0.2075</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>48</td><td><a href='https://ensembl.org/Search/Results?q=PRSS23'>PRSS23</a></td><td>PRSS23</td><td>21462</td><td>-0.116</td><td>-0.1456</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>49</td><td><a href='https://ensembl.org/Search/Results?q=IER3'>IER3</a></td><td>IER3</td><td>21480</td><td>-0.122</td><td>-0.0782</td><td bgcolor='#CCFFCC'>Yes</td></tr><tr><td class='lessen'>50</td><td><a href='https://ensembl.org/Search/Results?q=NDRG1'>NDRG1</a></td><td>NDRG1</td><td>21524</td><td>-0.149</td><td>0.0033</td><td bgcolor='#CCFFCC'>Yes</td></tr><caption class='table'>Table: GSEA details <a href='WANG_MES_2017.tsv'>[plain text format]</a></caption></table></div><br><div class='image'><img name='WANG_MES_2017' src='WANG_MES_2017_186.png'><br><br><caption>Fig 2: WANG_MES_2017    <br> Blue-Pink O' Gram in the Space of the Analyzed GeneSet</caption></div><br><div class='image'><img name='gset_rnd_es_dist' src='gset_rnd_es_dist_187.png'><br><br><caption>Fig 3: WANG_MES_2017: Random ES distribution    <br> Gene set null distribution of ES for <b>WANG_MES_2017</b></caption></div><br></body></html>