X1	Ensembl ID	HGNC symbol	DBD	Is TF?	TF assessment	Binding mode	Motif status	Final Notes	Final Comments	Interpro ID(s)	EntrezGene ID	EntrezGene Description	PDB ID	TF tested by HT-SELEX?	TF tested by PBM?	Conditional Binding Requirements	Original Comments	Vaquerizas 2009 classification	CisBP considers it a TF?	TFCat classification	Is a GO TF?	Initial assessment	Curator 1	Curator 2	TFclass considers it a TF?	Go Evidence	Pfam Domains (By ENSP ID)	Is C2H2 ZF(KRAB)?
0	ENSG00000137203	TFAP2A	AP-2	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR008121;IPR013854	7020	transcription factor AP-2 alpha [Source:HGNC Symbol;Acc:HGNC:11742]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11522791;15475956	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000137203#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7555706$#ENSG00000137203#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21084835$#ENSG00000137203#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550, PMID:20808827$#ENSG00000137203#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550, PMID:20066163, PMID:9520389	$#ENSP00000368928#ENSG00000137203#ENST00000379608#AP-2#$#ENSP00000368933#ENSG00000137203#ENST00000379613#AP-2#$#ENSP00000417495#ENSG00000137203#ENST00000466073#AP-2#$#ENSP00000417735#ENSG00000137203#ENST00000461628#AP-2#$#ENSP00000418391#ENSG00000137203#ENST00000465858#AP-2#$#ENSP00000419696#ENSG00000137203#ENST00000475264#AP-2#	FALSE
1	ENSG00000008196	TFAP2B	AP-2	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR008122;IPR013854	7021	transcription factor AP-2 beta [Source:HGNC Symbol;Acc:HGNC:11743]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7555706	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000008196#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7555706$#ENSG00000008196#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000008196#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000008196#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11505339, PMID:12169688, PMID:16373396	$#ENSP00000377265#ENSG00000008196#ENST00000393655#AP-2#$#ENSP00000342252#ENSG00000008196#ENST00000344788#AP-2#	FALSE
2	ENSG00000087510	TFAP2C	AP-2	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR008123;IPR013854	7022	transcription factor AP-2 gamma [Source:HGNC Symbol;Acc:HGNC:11744]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000087510#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550$#ENSG00000087510#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11278550$#ENSG00000087510#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9113991	$#ENSP00000201031#ENSG00000087510#ENST00000201031#AP-2#$#ENSP00000390857#ENSG00000087510#ENST00000416606#AP-2#	FALSE
3	ENSG00000008197	TFAP2D	AP-2	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds the same GCCTGAGGC sequence as the other AP-2s (PMID: 24789576)	IPR013854;	83741	transcription factor AP-2 delta [Source:HGNC Symbol;Acc:HGNC:15581]	None	not tested	not tested	None	None	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000008197#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000008391#ENSG00000008197#ENST00000008391#AP-2#	FALSE
4	ENSG00000116819	TFAP2E	AP-2	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR013854;	339488	transcription factor AP-2 epsilon [Source:HGNC Symbol;Acc:HGNC:30774]	None	Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14572467	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000116819#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000116819#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000362332#ENSG00000116819#ENST00000373235#AP-2#	FALSE
5	ENSG00000117713	ARID1A	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Non-specific DNA binder (PMID: 15170388).	IPR001606;IPR016024;IPR021906;	8289	AT-rich interaction domain 1A [Source:HGNC Symbol;Acc:HGNC:11110]	None	not tested	Yes	None	Chromatin_Modifier_etc	No	Yes	TF Gene_DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:15170388	No	4a, two or more datasets predict it as a TF	Matt Weirauch	Pratyush Das	No	None	$#ENSP00000320485#ENSG00000117713#ENST00000324856#ARID/BRIGHT#BAF250_C$#ENSP00000390317#ENSG00000117713#ENST00000430799#ARID/BRIGHT#BAF250_C$#ENSP00000489842#ENSG00000117713#ENST00000636219#ARID/BRIGHT#BAF250_C$#ENSP00000490650#ENSG00000117713#ENST00000637465#ARID/BRIGHT#	FALSE
6	ENSG00000049618	ARID1B	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Non-specific DNA binder (PMID: 15170388).	IPR001606;IPR021906	57492	AT-rich interaction domain 1B [Source:HGNC Symbol;Acc:HGNC:18040]	None	not tested	Yes	None	Chromatin_Modifier_etc	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:12200431;15170388	No	4a, two or more datasets predict it as a TF	Matt Weirauch	Jussi Taipale	Yes	None	$#ENSP00000344546#ENSG00000049618#ENST00000346085#ARID/BRIGHT#BAF250_C$#ENSP00000055163#ENSG00000049618#ENST00000350026#ARID/BRIGHT#BAF250_C$#ENSP00000313006#ENSG00000049618#ENST00000319584#ARID/BRIGHT#$#ENSP00000383596#ENSG00000049618#ENST00000400790#ARID/BRIGHT#$#ENSP00000490948#ENSG00000049618#ENST00000635849#ARID/BRIGHT#BAF250_C$#ENSP00000489717#ENSG00000049618#ENST00000635928#ARID/BRIGHT#BAF250_C$#ENSP00000490385#ENSG00000049618#ENST00000635957#ARID/BRIGHT#BAF250_C$#ENSP00000490050#ENSG00000049618#ENST00000636607#ARID/BRIGHT#$#ENSP00000489917#ENSG00000049618#ENST00000636748#ARID/BRIGHT#$#ENSP00000490491#ENSG00000049618#ENST00000636930#ARID/BRIGHT#BAF250_C$#ENSP00000489666#ENSG00000049618#ENST00000637003#ARID/BRIGHT#$#ENSP00000489729#ENSG00000049618#ENST00000637015#ARID/BRIGHT#BAF250_C$#ENSP00000490420#ENSG00000049618#ENST00000637532#ARID/BRIGHT#$#ENSP00000489636#ENSG00000049618#ENST00000637810#ARID/BRIGHT#BAF250_C$#ENSP00000490944#ENSG00000049618#ENST00000637887#ARID/BRIGHT#$#ENSP00000490550#ENSG00000049618#ENST00000637904#ARID/BRIGHT#BAF250_C$#ENSP00000489982#ENSG00000049618#ENST00000638000#ARID/BRIGHT#	FALSE
7	ENSG00000116017	ARID3A	ARID/BRIGHT	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001606;IPR023334	1820	AT-rich interaction domain 3A [Source:HGNC Symbol;Acc:HGNC:3031]	None	not tested	Yes	None	None	other	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15456761	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000116017#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000263620#ENSG00000116017#ENST00000263620#ARID/BRIGHT#$#ENSP00000464969#ENSG00000116017#ENST00000587532#ARID/BRIGHT#	FALSE
8	ENSG00000179361	ARID3B	ARID/BRIGHT	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001606;IPR023334	10620	AT-rich interaction domain 3B [Source:HGNC Symbol;Acc:HGNC:14350]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_DNA Binding; TF PPI_PMIDS:10446990	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000179361#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000179361#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000179361#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000343126#ENSG00000179361#ENST00000346246#ARID/BRIGHT#$#ENSP00000477878#ENSG00000179361#ENST00000622429#ARID/BRIGHT#$#ENSP00000455668#ENSG00000179361#ENST00000566147#ARID/BRIGHT#	FALSE
9	ENSG00000205143	ARID3C	ARID/BRIGHT	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001606;IPR023334	138715	AT-rich interaction domain 3C [Source:HGNC Symbol;Acc:HGNC:21209]	None	not tested	Yes	None	None	No	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:15922553	Yes	1a2, Orthologous HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000205143#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000368189#ENSG00000205143#ENST00000378909#ARID/BRIGHT#	FALSE
10	ENSG00000032219	ARID4A	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	Binds DNA in a sequence non-specific manner (PMID: 15640446).	IPR000953;IPR001606;IPR002999;IPR012603;IPR016197;IPR025995	5926	AT-rich interaction domain 4A [Source:HGNC Symbol;Acc:HGNC:9885]	None	not tested	Yes	None	Chromatin_Modifier_etc	No	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding_Other; TF PPI_PMIDS:10321733;10490602	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000032219#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8414517	$#ENSP00000347602#ENSG00000032219#ENST00000355431#ARID/BRIGHT#RBB1NT, Tudor-knot$#ENSP00000416053#ENSG00000032219#ENST00000417477#ARID/BRIGHT#Tudor-knot$#ENSP00000415872#ENSG00000032219#ENST00000424658#ARID/BRIGHT#$#ENSP00000392567#ENSG00000032219#ENST00000445108#ARID/BRIGHT#PWWP, RBB1NT	FALSE
11	ENSG00000054267	ARID4B	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in a sequence non-specific manner (PMID: 15640446).	IPR001606;IPR002999;IPR012603;IPR016197;IPR025995;	51742	AT-rich interaction domain 4B [Source:HGNC Symbol;Acc:HGNC:15550]	None	not tested	Yes	None	Chromatin_Modifier_etc	No	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation; TF PPI_PMIDS:12724404	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	None	$#ENSP00000264183#ENSG00000054267#ENST00000264183#ARID/BRIGHT#PWWP, RBB1NT, Tudor-knot$#ENSP00000264184#ENSG00000054267#ENST00000349213#ARID/BRIGHT#RBB1NT$#ENSP00000355562#ENSG00000054267#ENST00000366603#ARID/BRIGHT#PWWP, RBB1NT, Tudor-knot	FALSE
12	ENSG00000196843	ARID5A	ARID/BRIGHT	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001606;	10865	AT-rich interaction domain 5A [Source:HGNC Symbol;Acc:HGNC:17361]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000350078#ENSG00000196843#ENST00000357485#ARID/BRIGHT#$#ENSP00000400785#ENSG00000196843#ENST00000454558#ARID/BRIGHT#	FALSE
13	ENSG00000150347	ARID5B	ARID/BRIGHT	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	Has a putative AT-hook	None	IPR001606;	84159	AT-rich interaction domain 5B [Source:HGNC Symbol;Acc:HGNC:17362]	2OEH	not tested	Yes	None	None	other	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8649988;10329386	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000150347#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:8649988$#ENSG00000150347#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:21532585	$#ENSP00000279873#ENSG00000150347#ENST00000279873#ARID/BRIGHT#$#ENSP00000308862#ENSG00000150347#ENST00000309334#ARID/BRIGHT#	FALSE
14	ENSG00000008083	JARID2	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Only ARID3 and ARID5 family members have sequence specificity (PMID: 15640446).	IPR001606;IPR003347;IPR003349;IPR004198	3720	jumonji and AT-rich interaction domain containing 2 [Source:HGNC Symbol;Acc:HGNC:6196]	None	not tested	Yes	None	Chromatin_Modifier_etc	No	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Tim Hughes	Yes	$#ENSG00000008083#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000341280#ENSG00000008083#ENST00000341776#ARID/BRIGHT#JmjC, JmjN, zf-C5HC2$#ENSP00000380478#ENSG00000008083#ENST00000397311#ARID/BRIGHT#JmjC, JmjN, zf-C5HC2	FALSE
15	ENSG00000073614	KDM5A	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787;	5927	lysine demethylase 5A [Source:HGNC Symbol;Acc:HGNC:9886]	None	not tested	not tested	None	Chromatin_Modifier_etc	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9129143;11358960;15949438	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000073614#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8414517	$#ENSP00000382688#ENSG00000073614#ENST00000399788#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000440622#ENSG00000073614#ENST00000544760#ARID/BRIGHT#JmjC, JmjN, PLU-1, zf-C5HC2	FALSE
16	ENSG00000117139	KDM5B	ARID/BRIGHT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds GC-rich sequences such as CCGCCC (PMID: 18270511).	IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787;	10765	lysine demethylase 5B [Source:HGNC Symbol;Acc:HGNC:18039]	None	not tested	not tested	None	Chromatin_Modifier_etc	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12657635	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000117139#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10336460	$#ENSP00000356233#ENSG00000117139#ENST00000367264#ARID/BRIGHT#JmjC, JmjN, PHD, PHD_2, PLU-1, zf-C5HC2$#ENSP00000356234#ENSG00000117139#ENST00000367265#ARID/BRIGHT#JmjC, JmjN, PHD, PHD_2, PLU-1, zf-C5HC2$#ENSP00000235790#ENSG00000117139#ENST00000235790#ARID/BRIGHT#JmjC, PHD, PHD_2, PLU-1, zf-C5HC2, zf-PHD-like	FALSE
17	ENSG00000126012	KDM5C	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787;	8242	lysine demethylase 5C [Source:HGNC Symbol;Acc:HGNC:11114]	None	not tested	not tested	None	Chromatin_Modifier_etc	No	Yes	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:17320160	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000364550#ENSG00000126012#ENST00000375401#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000385394#ENSG00000126012#ENST00000404049#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2	FALSE
18	ENSG00000012817	KDM5D	ARID/BRIGHT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Polycomb protein that is well-documented to bind histone marks (PMID: 27477906; PMID: 17351630; PMID: 17320160; PMID: 17320162).	IPR001606;IPR001965;IPR003347;IPR003349;IPR004198;IPR011011;IPR013637;IPR019786;IPR019787;	8284	lysine demethylase 5D [Source:HGNC Symbol;Acc:HGNC:11115]	None	not tested	not tested	None	Chromatin_Modifier_etc	No	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000322408#ENSG00000012817#ENST00000317961#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000372256#ENSG00000012817#ENST00000382806#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000444293#ENSG00000012817#ENST00000541639#ARID/BRIGHT#JmjC, JmjN, PHD, PLU-1, zf-C5HC2$#ENSP00000416377#ENSG00000012817#ENST00000447300#ARID/BRIGHT#JmjN, PHD$#ENSP00000389433#ENSG00000012817#ENST00000415360#ARID/BRIGHT#PHD, PLU-1	FALSE
19	ENSG00000189079	ARID2	ARID/BRIGHT; RFX	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001606;IPR003150;IPR007087;IPR016024	196528	AT-rich interaction domain 2 [Source:HGNC Symbol;Acc:HGNC:18037]	None	not tested	Yes	None	None	x	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16782067	No	1a2, Orthologous HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000335044#ENSG00000189079#ENST00000334344#ARID/BRIGHT, RFX#$#ENSP00000415650#ENSG00000189079#ENST00000422737#ARID/BRIGHT, RFX#$#ENSP00000397307#ENSG00000189079#ENST00000444670#ARID/BRIGHT, RFX#$#ENSP00000388357#ENSG00000189079#ENST00000457135#ARID/BRIGHT, RFX#FOXP-CC$#ENSP00000481488#ENSG00000189079#ENST00000477947#ARID/BRIGHT, RFX#	FALSE
20	ENSG00000153207	AHCTF1	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR011047;IPR025151	25909	AT-hook containing transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:24618]	None	not tested	Yes	None	None	c	No	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	No	$#ENSG00000153207#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000355465#ENSG00000153207#ENST00000326225#AT hook#ELYS, ELYS-bb$#ENSP00000417115#ENSG00000153207#ENST00000478568#AT hook#ELYS-bb$#ENSP00000355464#ENSG00000153207#ENST00000366508#AT hook#ELYS, ELYS-bb	FALSE
21	ENSG00000126705	AHDC1	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	None	27245	AT-hook DNA binding motif containing 1 [Source:HGNC Symbol;Acc:HGNC:25230]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000247087#ENSG00000126705#ENST00000247087#AT hook#DUF4683$#ENSP00000363123#ENSG00000126705#ENST00000374011#AT hook#DUF4683	FALSE
22	ENSG00000106948	AKNA	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds AT-rich promoters of CD40 and CD40L and coordinates their expression (PMID: 11268217).	IPR022150;	80709	AT-hook transcription factor [Source:HGNC Symbol;Acc:HGNC:24108]	None	Full	not tested	None	None	c	No	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000106948#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11268217	$#ENSP00000303769#ENSG00000106948#ENST00000307564#AT hook#AKNA$#ENSP00000309222#ENSG00000106948#ENST00000312033#AT hook#AKNA$#ENSP00000363188#ENSG00000106948#ENST00000374075#AT hook#AKNA$#ENSP00000363192#ENSG00000106948#ENST00000374079#AT hook#$#ENSP00000223791#ENSG00000106948#ENST00000223791#AT hook#AKNA$#ENSP00000363201#ENSG00000106948#ENST00000374088#AT hook#AKNA	FALSE
23	ENSG00000116539	ASH1L	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001025;IPR001214;IPR001487;IPR001965;IPR003616;IPR006560;IPR011011;IPR017956;IPR019786;IPR019787	693140	ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088]	None	not tested	not tested	Chromatin_Modifier_etc	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000357330#ENSG00000116539#ENST00000368346#AT hook#BAH, Bromodomain, PHD, SET$#ENSP00000376204#ENSG00000116539#ENST00000392403#AT hook#BAH, Bromodomain, PHD, SET$#ENSP00000449283#ENSG00000116539#ENST00000548830#AT hook#	FALSE
24	ENSG00000173894	CBX2	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000953;IPR016197;IPR017984;IPR023779;IPR023780;	84733	chromobox 2 [Source:HGNC Symbol;Acc:HGNC:1552]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000269399#ENSG00000173894#ENST00000269399#Other#Chromo, Tudor-knot$#ENSP00000308750#ENSG00000173894#ENST00000310942#Other#CBX7_C, Chromo	FALSE
25	ENSG00000101457	DNTTIP1	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	None	116092	deoxynucleotidyltransferase, terminal, interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16160]	None	not tested	not tested	None	PMID:11473582 Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase that enhances Ig and TcR gene diversity in the N region in B- and T-cells.	No	No	No	No	2a1, Lower confidence direct evidence	Yimeng Yin	Arttu Jolma	No	None	$##ENSG00000101457##Other#	FALSE
26	ENSG00000104885	DOT1L	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR013110;IPR021169;IPR025789;IPR029063	84444	DOT1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:24948]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$#ENSP00000381657#ENSG00000104885#ENST00000398665#Other#DOT1$#ENSP00000412916#ENSG00000104885#ENST00000446286#Other#$#ENSP00000404284#ENSG00000104885#ENST00000452696#Other#DOT1$#ENSP00000476469#ENSG00000104885#ENST00000586024#Other#	FALSE
27	ENSG00000140632	GLYR1	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	IPR000313;IPR006115;IPR008927;IPR029154	84656	glyoxylate reductase 1 homolog	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000322716#ENSG00000140632#ENST00000321919#Other#2-Hacid_dh_C, 3HCDH_N, ApbA, F420_oxidored, NAD_bi$#ENSP00000466570#ENSG00000140632#ENST00000589389#Other#2-Hacid_dh_C, 3HCDH_N, ApbA, F420_oxidored, NAD_bi$#ENSP00000468328#ENSG00000140632#ENST00000591451#Other#2-Hacid_dh_C, 3HCDH_N, F420_oxidored, NAD_binding_$#ENSP00000390276#ENSG00000140632#ENST00000436648#Other#2-Hacid_dh_C, 3HCDH_N, ApbA, F420_oxidored, NAD_bi$#ENSP00000467541#ENSG00000140632#ENST00000587297#Other#$#ENSP00000467751#ENSG00000140632#ENST00000588297#Other#PWWP	FALSE
28	ENSG00000137309	HMGA1	AT hook	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000116;IPR000637;IPR017956;IPR020478	3159	high mobility group AT-hook 1 [Source:HGNC Symbol;Acc:HGNC:5010]	2EZD	not tested	not tested	None	Pmid:9253416 Architectural HMG	c	Yes	TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:9199299;12907668	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000137309#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#ISS - GO_REF:0000024$#ENSG00000137309#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000308227#ENSG00000137309#ENST00000311487#AT hook#$#ENSP00000288245#ENSG00000137309#ENST00000347617#AT hook#$#ENSP00000363230#ENSG00000137309#ENST00000374116#AT hook#$#ENSP00000385693#ENSG00000137309#ENST00000401473#AT hook#$#ENSP00000399888#ENSG00000137309#ENST00000447654#AT hook#	FALSE
29	ENSG00000149948	HMGA2	AT hook	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000116;IPR000637;IPR017956;IPR020478	8091	high mobility group AT-hook 2 [Source:HGNC Symbol;Acc:HGNC:5009]	None	not tested	Yes	None	None	x	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000149948#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18832382$#ENSG00000149948#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14627817	$#ENSP00000346658#ENSG00000149948#ENST00000354636#AT hook#$#ENSP00000377206#ENSG00000149948#ENST00000393578#AT hook#$#ENSP00000384026#ENSG00000149948#ENST00000403681#AT hook#$#ENSP00000407306#ENSG00000149948#ENST00000425208#AT hook#$#ENSP00000437621#ENSG00000149948#ENST00000536545#AT hook#$#ENSP00000439317#ENSG00000149948#ENST00000541363#AT hook#$#ENSP00000377205#ENSG00000149948#ENST00000393577#AT hook#	FALSE
30	ENSG00000025293	PHF20	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001965;IPR002999;IPR007087;IPR011011;IPR019786;IPR019787;IPR022255;	51230	PHD finger protein 20 [Source:HGNC Symbol;Acc:HGNC:16098]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$#ENSP00000363112#ENSG00000025293#ENST00000374000#Other#DUF3776, DUF4537, LBR_tudor, MBT, Rad9_Rad53_bind,$#ENSP00000363124#ENSG00000025293#ENST00000374012#Other#DUF1325, DUF3776, DUF4537, LBR_tudor, MBT, PHD, Ra$#ENSP00000341900#ENSG00000025293#ENST00000339089#Other#DUF1325, DUF3776, DUF4537, LBR_tudor, MBT, Rad9_Ra$#ENSP00000413712#ENSG00000025293#ENST00000420233#Other#	FALSE
31	ENSG00000135365	PHF21A	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	IPR001965;IPR011011;IPR017956;IPR019786;IPR019787;	51317	PHD finger protein 21A [Source:HGNC Symbol;Acc:HGNC:24156]	None	not tested	not tested	None	None	x	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000323152#ENSG00000135365#ENST00000323180#Other#C1_1, PHD, PHD_2$#ENSP00000398824#ENSG00000135365#ENST00000418153#Other#C1_1, PHD, PHD_2, zf-HC5HC2H$#ENSP00000431621#ENSG00000135365#ENST00000532028#Other#DUF1043, DUF1664, HOOK, S6OS1	FALSE
32	ENSG00000126464	PRR12	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR025451;	57479	proline rich 12 [Source:HGNC Symbol;Acc:HGNC:29217]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Tim Hughes	No	None	$#ENSP00000394510#ENSG00000126464#ENST00000418929#Other#DUF4211$#ENSP00000478000#ENSG00000126464#ENST00000615927#Other#DUF4211	FALSE
33	ENSG00000146285	SCML4	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001660;IPR013761;IPR021129;IPR021987	256380	sex comb on midleg-like 4 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:21397]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000358021#ENSG00000146285#ENST00000369025#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000358018#ENSG00000146285#ENST00000369022#Other#SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000404688#ENSG00000146285#ENST00000440927#Other#SLED	FALSE
34	ENSG00000152217	SETBP1	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Orthologous protein from mouse (Setbp1) bind DNA sequence-specifically by PBM	IPR017956;	26040	SET binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15573]	None	not tested	Yes	None	None	c	No	No	No	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	No	None	$#ENSP00000282030#ENSG00000152217#ENST00000282030#AT hook#$#ENSP00000390687#ENSG00000152217#ENST00000426838#AT hook#$#ENSP00000468506#ENSG00000152217#ENST00000591940#AT hook#	FALSE
35	ENSG00000080603	SRCAP	AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000330;IPR001650;IPR013999;IPR014001;IPR014012;IPR017956;IPR020478;IPR027417	10847	Snf2-related CREBBP activator protein [Source:HGNC Symbol;Acc:HGNC:16974]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$#ENSP00000262518#ENSG00000080603#ENST00000262518#AT hook#DEAD, HSA, Helicase_C, SNF2_N$#ENSP00000378499#ENSG00000080603#ENST00000395059#AT hook#DEAD, Helicase_C, SNF2_N$#ENSP00000483329#ENSG00000080603#ENST00000483083#AT hook#ResIII, SNF2_N$#ENSP00000405186#ENSG00000080603#ENST00000411466#AT hook#	FALSE
36	ENSG00000188070	C11orf95	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR015880;	65998	chromosome 11 open reading frame 95 [Source:HGNC Symbol;Acc:HGNC:28449]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000483097#ENSG00000188070#ENST00000338498#BED ZF#$#ENSP00000482857#ENSG00000188070#ENST00000546282#BED ZF#$#ENSP00000482180#ENSG00000188070#ENST00000433688#BED ZF#DUF678, Trm112p$#ENSP00000478462#ENSG00000188070#ENST00000445014#BED ZF#	FALSE
37	ENSG00000237765	FAM200B	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR012337	285550	family with sequence similarity 200 member B [Source:HGNC Symbol;Acc:HGNC:27740]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000237765#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000393017#ENSG00000237765#ENST00000422728#BED ZF#$#ENSP00000483930#ENSG00000237765#ENST00000622362#BED ZF#$#ENSP00000422751#ENSG00000237765#ENST00000503617#BED ZF#	FALSE
38	ENSG00000141258	SGSM2	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000195;IPR004012	9905	small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$#ENSP00000268989#ENSG00000141258#ENST00000268989#BED ZF#DUF3548, RUN, RabGAP-TBC$#ENSP00000415107#ENSG00000141258#ENST00000426855#BED ZF#DUF3548, RUN, RabGAP-TBC$#ENSP00000464593#ENSG00000141258#ENST00000573851#BED ZF#RabGAP-TBC$#ENSP00000459126#ENSG00000141258#ENST00000574563#BED ZF#DUF3548, RUN, RabGAP-TBC$#ENSP00000460205#ENSG00000141258#ENST00000570431#BED ZF#DUF3548$#ENSP00000461820#ENSG00000141258#ENST00000572925#BED ZF#$#ENSP00000476637#ENSG00000141258#ENST00000574650#BED ZF#RUN	FALSE
39	ENSG00000214717	ZBED1	BED ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003656;IPR008906;IPR012337;	9189	zinc finger BED-type containing 1 [Source:HGNC Symbol;Acc:HGNC:447]	None	DBD	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000214717#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000370616#ENSG00000214717#ENST00000381218#BED ZF#DUF4413, Dimer_Tnp_hAT$#ENSP00000370620#ENSG00000214717#ENST00000381222#BED ZF#DUF4413, Dimer_Tnp_hAT$#ENSP00000370621#ENSG00000214717#ENST00000381223#BED ZF#DUF4413, Dimer_Tnp_hAT$#ENSP00000419148#ENSG00000214717#ENST00000461691#BED ZF#	FALSE
40	ENSG00000177494	ZBED2	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a BED domain that should bind DNA, but lacks the dimerization domain (PMID: 20016685).	IPR003656;	79413	zinc finger BED-type containing 2 [Source:HGNC Symbol;Acc:HGNC:20710]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000321370#ENSG00000177494#ENST00000317012#BED ZF#	FALSE
41	ENSG00000132846	ZBED3	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003656;	84327	zinc finger BED-type containing 3 [Source:HGNC Symbol;Acc:HGNC:20711]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000255198#ENSG00000132846#ENST00000255198#BED ZF#$#ENSP00000427487#ENSG00000132846#ENST00000511587#BED ZF#	FALSE
42	ENSG00000100426	ZBED4	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003656;IPR008906;IPR012337;	9889	zinc finger BED-type containing 4 [Source:HGNC Symbol;Acc:HGNC:20721]	None	Full	Yes	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000100426#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000216268#ENSG00000100426#ENST00000216268#BED ZF#Dimer_Tnp_hAT	FALSE
43	ENSG00000236287	ZBED5	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003656;IPR012337	58486	zinc finger BED-type containing 5 [Source:HGNC Symbol;Acc:HGNC:30803]	None	not tested	not tested	None	None	No	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000236287#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000415939#ENSG00000236287#ENST00000413761#BED ZF#DUF3887$#ENSP00000398106#ENSG00000236287#ENST00000432999#BED ZF#DUF3887$#ENSP00000433093#ENSG00000236287#ENST00000526020#BED ZF#	FALSE
44	ENSG00000257315	ZBED6	BED ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR003656;IPR008906;IPR012337	100381270	zinc finger BED-type containing 6 [Source:HGNC Symbol;Acc:HGNC:33273]	None	not tested	not tested	None	None	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000257315#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000447879#ENSG00000257315#ENST00000550078#BED ZF#Dimer_Tnp_hAT	FALSE
45	ENSG00000221886	ZBED8	BED ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Despite its name, does not have a detectable BED ZF domain.	IPR012337	63920	zinc finger BED-type containing 8 [Source:HGNC Symbol;Acc:HGNC:30804]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000221886#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000428831#ENSG00000221886#ENST00000523213#Other#Dimer_Tnp_hAT$#ENSP00000386184#ENSG00000221886#ENST00000408953#Other#Dimer_Tnp_hAT	FALSE
46	ENSG00000232040	ZBED9	BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001584;IPR003309;IPR008916;IPR012337	None	zinc finger BED-type containing 9 [Source:HGNC Symbol;Acc:HGNC:13851]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	No	None	None	FALSE
47	ENSG00000106546	AHR	bHLH	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000014;IPR001610;IPR011598;IPR013655;IPR013767;	196	aryl hydrocarbon receptor [Source:HGNC Symbol;Acc:HGNC:348]	None	DBD and Full	Yes	Obligate_Multimer, 4ZPR is structure of heterodime	PMID:12213385, forms heterodimers with ARNT	other	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7592839	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000106546#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11782478$#ENSG00000106546#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:10395741	$#ENSP00000242057#ENSG00000106546#ENST00000242057#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9	FALSE
48	ENSG00000063438	AHRR	bHLH	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000014;IPR011598;IPR013767;	57491	aryl-hydrocarbon receptor repressor [Source:HGNC Symbol;Acc:HGNC:346]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Tim Hughes	Yes	None	$#ENSP00000323816#ENSG00000063438#ENST00000316418#bHLH#PAS, PAS_4$#ENSP00000424601#ENSG00000063438#ENST00000505113#bHLH#PAS, PAS_4$#ENSP00000426932#ENSG00000063438#ENST00000506456#bHLH#$#ENSP00000429944#ENSG00000063438#ENST00000504625#bHLH#$#ENSP00000426076#ENSG00000063438#ENST00000511487#bHLH#	FALSE
49	ENSG00000143437	ARNT	bHLH	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;	405	aryl hydrocarbon receptor nuclear translocator [Source:HGNC Symbol;Acc:HGNC:700]	4ZPR	DBD and Full	Yes	Obligate_Multimer, the structure4ZPR is a HIF1A-AR	Structure has HIF1A -  ARNT heterodimer; Heterodimerizes with ARNT, PMID:7539918, PubMed: 26245371 for the crystal structure	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7592839	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000143437#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10777486, PMID:1317062$#ENSG00000143437#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:7539918, PMID:8756616	$#ENSP00000346372#ENSG00000143437#ENST00000354396#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000351407#ENSG00000143437#ENST00000358595#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000423851#ENSG00000143437#ENST00000515192#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000427571#ENSG00000143437#ENST00000505755#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9	FALSE
50	ENSG00000172379	ARNT2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;	100847042	aryl hydrocarbon receptor nuclear translocator 2 [Source:HGNC Symbol;Acc:HGNC:16876]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8657146	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000172379#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24465693$#ENSG00000172379#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172379#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000307479#ENSG00000172379#ENST00000303329#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000453792#ENSG00000172379#ENST00000527771#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000479393#ENSG00000172379#ENST00000622346#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000452961#ENSG00000172379#ENST00000525103#bHLH#	FALSE
51	ENSG00000133794	ARNTL	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;	406	aryl hydrocarbon receptor nuclear translocator like [Source:HGNC Symbol;Acc:HGNC:701]	4H10	DBD and Full	Yes	None	Structure is ARNTL-CLOCK heterodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9576906;9616112	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000133794#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024	$#ENSP00000374357#ENSG00000133794#ENST00000389707#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000385915#ENSG00000133794#ENST00000401424#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000384517#ENSG00000133794#ENST00000403290#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000385897#ENSG00000133794#ENST00000403482#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000385581#ENSG00000133794#ENST00000403510#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000436721#ENSG00000133794#ENST00000482049#bHLH#	FALSE
52	ENSG00000029153	ARNTL2	bHLH	Yes	Inferred motif	Obligate heteromer	High-throughput in vitro	None	ARNTL2 Forms heterodimers with CLOCK and NPAS2 (PMID:10864977 ).	IPR000014;IPR001067;IPR011598;IPR013767	56938	aryl hydrocarbon receptor nuclear translocator like 2 [Source:HGNC Symbol;Acc:HGNC:18984]	None	DBD and Full	Yes	None	PMID:10864977 ARNTL2 Forms heterodimers with CLOCK and NPAS2	a	Yes	No	Yes	1a2, Orthologous HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000029153#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15147242$#ENSG00000029153#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12055078 | NAS - PMID:11018023	$#ENSP00000261178#ENSG00000029153#ENST00000261178#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000266503#ENSG00000029153#ENST00000266503#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000312247#ENSG00000029153#ENST00000311001#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000379238#ENSG00000029153#ENST00000395901#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000400185#ENSG00000029153#ENST00000457040#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000445836#ENSG00000029153#ENST00000542388#bHLH#PAS, PAS_11, PAS_2, PAS_3, PAS_4, PAS_9$#ENSP00000438545#ENSG00000029153#ENST00000546179#bHLH#PAS, PAS_11, PAS_2, PAS_3, PAS_4, PAS_9	FALSE
53	ENSG00000139352	ASCL1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	429	achaete-scute family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:738]	None	DBD	Yes	None	pmid:10903890, prefers heterodimerization with TCF3	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8662987;8900141	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000139352#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11736660$#ENSG00000139352#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10903890	$#ENSP00000266744#ENSG00000139352#ENST00000266744#bHLH#	FALSE
54	ENSG00000183734	ASCL2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	430	achaete-scute family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:739]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000183734#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14561729$#ENSG00000183734#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8751384	$#ENSP00000332293#ENSG00000183734#ENST00000331289#bHLH#	FALSE
55	ENSG00000176009	ASCL3	bHLH	Yes	Inferred motif	Obligate heteromer	High-throughput in vitro	None	ASCL1 heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 24835951).	IPR011598;	56676	Achaete-scute family bHLH transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:740]	None	DBD	Yes	None	ASCL1 heterodimerizes with TCF3	a	Yes	No	No	3a, decent circumstantial evidence for its role as	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000176009#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000176009#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000435770#ENSG00000176009#ENST00000531618#bHLH#	FALSE
56	ENSG00000187855	ASCL4	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs	IPR011598;	121549	Achaete-scute family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24311]	None	DBD and Full	not tested	None	ASCL1 heterodimerizes with TCF3	a	Yes	No	No	3a, decent circumstantial evidence for its role as	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000187855#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000345420#ENSG00000187855#ENST00000342331#bHLH#	FALSE
57	ENSG00000232237	ASCL5	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs	IPR011598	647219	Achaete-scute family bHLH transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:33169]	None	not tested	not tested	None	ASCL1 heterodimerizes with TCF3	No	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000232237#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000472681#ENSG00000232237#ENST00000449188#bHLH#$#ENSP00000469019#ENSG00000232237#ENST00000458416#bHLH#	FALSE
58	ENSG00000172238	ATOH1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	474	atonal bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:797]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:14757642	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000172238#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172238#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8872459	$#ENSP00000302216#ENSG00000172238#ENST00000306011#bHLH#	FALSE
59	ENSG00000179774	ATOH7	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	220202	atonal bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:13907]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__Transactivation_PMIDS:7721778;15882586;17653051	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000362777#ENSG00000179774#ENST00000373673#bHLH#	FALSE
60	ENSG00000168874	ATOH8	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	84913	atonal bHLH transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24126]	None	DBD	Yes	None	ATOH8 Is thought to make a heterodimer with TCF3	c	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:11733035;12419857	Yes	1a2, Orthologous HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000168874#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:24236640	$#ENSP00000304676#ENSG00000168874#ENST00000306279#bHLH#	FALSE
61	ENSG00000180535	BHLHA15	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	168620	basic helix-loop-helix family member a15 [Source:HGNC Symbol;Acc:HGNC:22265]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000180535#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000476312#ENSG00000180535#ENST00000609256#bHLH#$#ENSP00000326391#ENSG00000180535#ENST00000314018#bHLH#	FALSE
62	ENSG00000205899	BHLHA9	bHLH	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	Protein heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 25466284).	IPR011598;	727857	basic helix-loop-helix family member a9 [Source:HGNC Symbol;Acc:HGNC:35126]	None	DBD	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000375248#ENSG00000205899#ENST00000391429#bHLH#	FALSE
63	ENSG00000180828	BHLHE22	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	27319	basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963]	None	DBD	Yes	None	Vaquerizas dataset used old symbol BHLHB5	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000180828#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000318799#ENSG00000180828#ENST00000321870#bHLH#	FALSE
64	ENSG00000125533	BHLHE23	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	128408	basic helix-loop-helix family member e23 [Source:HGNC Symbol;Acc:HGNC:16093]	None	DBD and Full	Yes	None	Vaquerizas dataset used old symbol BHLHB4; pmid:15363390, protein is required for rod cell maturation	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000359371#ENSG00000125533#ENST00000370346#bHLH#$#ENSP00000480998#ENSG00000125533#ENST00000612929#bHLH#	FALSE
65	ENSG00000134107	BHLHE40	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	8553	basic helix-loop-helix family member e40 [Source:HGNC Symbol;Acc:HGNC:1046]	None	DBD and Full	Yes	None	Cell2013 has old symbol BHLHB2	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:12297495;12397359	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000134107#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12397359$#ENSG00000134107#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12624110, PMID:15193144, PMID:18411297$#ENSG00000134107#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9240428$#ENSG00000134107#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000134107#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18411297	$#ENSP00000256495#ENSG00000134107#ENST00000256495#bHLH#Hairy_orange	FALSE
66	ENSG00000123095	BHLHE41	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	79365	basic helix-loop-helix family member e41 [Source:HGNC Symbol;Acc:HGNC:16617]	None	DBD and Full	Yes	None	Cell2013 has old symbol BHLHB3	b	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Other_PMIDS:12657651;15448136	Yes	1a1, Direct HQ evidence	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000123095#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000123095#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000242728#ENSG00000123095#ENST00000242728#bHLH#Hairy_orange	FALSE
67	ENSG00000250709	CCDC169-SOHLH2	bHLH	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR011598;IPR028022	100526761	CCDC169-SOHLH2 readthrough [Source:HGNC Symbol;Acc:HGNC:38866]	None	not tested	not tested	None	None	No	Yes	No	No	1a2, Orthologous HQ evidence	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000421868#ENSG00000250709#ENST00000511166#bHLH#DUF4600	FALSE
68	ENSG00000134852	CLOCK	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Can also bind as heterodimer with ARNTL.	IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;	9575	clock circadian regulator [Source:HGNC Symbol;Acc:HGNC:2082]	4H10	DBD and Full	Yes	None	Structure is ARNTL-CLOCK heterodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9616112;15147242;15500444	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000134852#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000134852#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000134852#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000308741#ENSG00000134852#ENST00000309964#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000370723#ENSG00000134852#ENST00000381322#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000426983#ENSG00000134852#ENST00000513440#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000396649#ENSG00000134852#ENST00000435527#bHLH#PAS, PAS_9	FALSE
69	ENSG00000116016	EPAS1	bHLH	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;IPR014887;IPR021537;	2034	endothelial PAS domain protein 1 [Source:HGNC Symbol;Acc:HGNC:3374]	4ZPK	DBD and Full	Yes	Obligate_Multimer	4ZPK is EPAS1 -  ARNT heterodimer; Heterodimerizes with ARNT, PMID: 26245371 for the crystal structure;	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:15190133	Yes	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	$#ENSG00000116016#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000116016#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000263734#ENSG00000116016#ENST00000263734#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000406137#ENSG00000116016#ENST00000449347#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9	FALSE
70	ENSG00000146618	FERD3L	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	222894	Fer3-like bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:16660]	None	DBD and Full	Yes	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000146618#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000275461#ENSG00000146618#ENST00000275461#bHLH#	FALSE
71	ENSG00000183733	FIGLA	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	344018	folliculogenesis specific bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:24669]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9362457;15044608	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000183733#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000333097#ENSG00000183733#ENST00000332372#bHLH#	FALSE
72	ENSG00000113196	HAND1	bHLH	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Obligate heteromer (PMID: 10611232).	IPR011598;	9421	heart and neural crest derivatives expressed 1 [Source:HGNC Symbol;Acc:HGNC:4807]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7791788;11802795;16043483;7671815;15509787;16043483;10611232;16043483	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000113196#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11802795$#ENSG00000113196#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11802795	$#ENSP00000231121#ENSG00000113196#ENST00000231121#bHLH#	FALSE
73	ENSG00000164107	HAND2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	9464	heart and neural crest derivatives expressed 2 [Source:HGNC Symbol;Acc:HGNC:4808]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_TF PPI; Transactivation_PMIDS:11812799;12392994	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000164107#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15486975$#ENSG00000164107#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000352565#ENSG00000164107#ENST00000359562#bHLH#$#ENSP00000477638#ENSG00000164107#ENST00000621866#bHLH#	FALSE
74	ENSG00000187821	HELT	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Can form homodimers or heterodimers with HEY2 and HES5, suggesting also that the HELT homodimer is dependent of a additional Orange domain while the HEY2 heterodimer requires just the DBD (PMID: 14764602).	IPR003650;IPR011598	391723	helt bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:33783]	None	DBD	Yes	None	PMID: 14764602 shows that it can form homodimers or heterodimers with HEY2 and HES5, suggesting also that the homodimer or heterodimer is dependent of a additional Orange domain while the HEY2 heterodimer requires just the DBD	c	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14764602;15071116	Yes	3a, decent circumstantial evidence for its role as	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000187821#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000422140#ENSG00000187821#ENST00000505610#bHLH#Hairy_orange$#ENSP00000426033#ENSG00000187821#ENST00000515777#bHLH#Hairy_orange$#ENSP00000343464#ENSG00000187821#ENST00000338875#bHLH#Hairy_orange	FALSE
75	ENSG00000114315	HES1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	3280	hes family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5192]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000114315#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000114315#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17681138	$#ENSP00000232424#ENSG00000114315#ENST00000232424#bHLH#Hairy_orange	FALSE
76	ENSG00000069812	HES2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	54626	hes family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:16005]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8354270	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000367065#ENSG00000069812#ENST00000377834#bHLH#Hairy_orange$#ENSP00000367068#ENSG00000069812#ENST00000377837#bHLH#$#ENSP00000367067#ENSG00000069812#ENST00000377836#bHLH#$#ENSP00000465270#ENSG00000069812#ENST00000489730#bHLH#$#ENSP00000465248#ENSG00000069812#ENST00000487437#bHLH#	FALSE
77	ENSG00000173673	HES3	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	390992	hes family bHLH transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:26226]	None	DBD	Yes	None	None	c	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10858455	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000367130#ENSG00000173673#ENST00000377898#bHLH#	FALSE
78	ENSG00000188290	HES4	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	57801	hes family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24149]	None	DBD	not tested	None	None	b	Yes	No	No	1a2, Orthologous HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000304595#ENSG00000188290#ENST00000304952#bHLH#Hairy_orange$#ENSP00000393198#ENSG00000188290#ENST00000428771#bHLH#Hairy_orange$#ENSP00000425085#ENSG00000188290#ENST00000484667#bHLH#Hairy_orange	FALSE
79	ENSG00000197921	HES5	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	388585	hes family bHLH transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:19764]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:15156153	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000197921#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024	$#ENSP00000367714#ENSG00000197921#ENST00000378453#bHLH#Hairy_orange	FALSE
80	ENSG00000144485	HES6	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	55502	hes family bHLH transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:18254]	None	DBD and Full	Yes	None	None	x	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10851137;10976052	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000144485#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000144485#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10851137	$#ENSP00000272937#ENSG00000144485#ENST00000272937#bHLH#Hairy_orange$#ENSP00000387155#ENSG00000144485#ENST00000409002#bHLH#Hairy_orange$#ENSP00000387215#ENSG00000144485#ENST00000409160#bHLH#$#ENSP00000387343#ENSG00000144485#ENST00000409182#bHLH#Hairy_orange$#ENSP00000387107#ENSG00000144485#ENST00000409356#bHLH#$#ENSP00000387008#ENSG00000144485#ENST00000409574#bHLH#$#ENSP00000401797#ENSG00000144485#ENST00000417803#bHLH#$#ENSP00000392596#ENSG00000144485#ENST00000436051#bHLH#$#ENSP00000390870#ENSG00000144485#ENST00000450098#bHLH#	FALSE
81	ENSG00000179111	HES7	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also forms heterodimers.	IPR003650;IPR011598	84667	hes family bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:15977]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate__Other_PMIDS:11260262;12783854	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000314774#ENSG00000179111#ENST00000317814#bHLH#$#ENSP00000446205#ENSG00000179111#ENST00000541682#bHLH#$#ENSP00000462491#ENSG00000179111#ENST00000577735#bHLH#	FALSE
82	ENSG00000164683	HEY1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	23462	hes related family bHLH transcription factor with YRPW motif 1 [Source:HGNC Symbol;Acc:HGNC:4880]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:16199874	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000164683#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000164683#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15485867	$#ENSP00000338272#ENSG00000164683#ENST00000337919#bHLH#Hairy_orange$#ENSP00000346761#ENSG00000164683#ENST00000354724#bHLH#Hairy_orange$#ENSP00000429792#ENSG00000164683#ENST00000523976#bHLH#Hairy_orange$#ENSP00000429705#ENSG00000164683#ENST00000518733#bHLH#Hairy_orange	FALSE
83	ENSG00000135547	HEY2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	23493	hes related family bHLH transcription factor with YRPW motif 2 [Source:HGNC Symbol;Acc:HGNC:4881]	None	DBD and Full	Yes	None	Can also form heterodimer with HELT	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000135547#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000135547#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15485867	$#ENSP00000357348#ENSG00000135547#ENST00000368364#bHLH#Hairy_orange$#ENSP00000357349#ENSG00000135547#ENST00000368365#bHLH#Hairy_orange	FALSE
84	ENSG00000163909	HEYL	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003650;IPR011598	26508	hes related family bHLH transcription factor with YRPW motif-like [Source:HGNC Symbol;Acc:HGNC:4882]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a2, Orthologous HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000163909#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000163909#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163909#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15485867$#ENSG00000163909#GO:2000824#negative regulation of androgen receptor activity#IDA - PMID:21454491	$#ENSP00000361943#ENSG00000163909#ENST00000372852#bHLH#Hairy_orange	FALSE
85	ENSG00000100644	HIF1A	bHLH	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds as obligate heteromer with ARNT (PMID: 9027737).	IPR000014;IPR001321;IPR001610;IPR011598;IPR013767;IPR014887;IPR021537;	3091	hypoxia inducible factor 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:4910]	4ZPR	DBD and Full	Yes	Obligate_Multimer	4ZPR is structure of HIF1A - ARNT heterodimer;Heterodimerizes with ARNT, PMID:7539918, PubMed: 26245371 for the crystal structure	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:12133832;15111179;15906272	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000100644#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000100644#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:24983504$#ENSG00000100644#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11782478, PMID:18658046 | TAS - PMID:15$#ENSG00000100644#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:7539918, PMID:8387214, PMID:8756616, PM	$#ENSP00000323326#ENSG00000100644#ENST00000323441#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000338018#ENSG00000100644#ENST00000337138#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000378446#ENSG00000100644#ENST00000394997#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000437955#ENSG00000100644#ENST00000539097#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS$#ENSP00000451696#ENSG00000100644#ENST00000557538#bHLH#HIF-1, HIF-1a_CTAD, PAS, PAS_11, PAS_3, PAS_4, PAS	FALSE
86	ENSG00000124440	HIF3A	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Binds DNA as a heterodimer with ARNT and ARNT2; reviewed in (PMID: 24099156).	IPR000014;IPR001610;IPR011598;IPR013767;IPR021537;	64344	hypoxia inducible factor 3 alpha subunit [Source:HGNC Symbol;Acc:HGNC:15825]	None	DBD	Yes	None	None	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000124440#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000300862#ENSG00000124440#ENST00000300862#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000366898#ENSG00000124440#ENST00000377670#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000244303#ENSG00000124440#ENST00000244303#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000434653#ENSG00000124440#ENST00000472815#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000471560#ENSG00000124440#ENST00000600383#bHLH#HIF-1, PAS, PAS_11, PAS_3, PAS_4, PAS_9	FALSE
87	ENSG00000125968	ID1	bHLH	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination	IPR011598;	3397	inhibitor of DNA binding 1, HLH protein [Source:HGNC Symbol;Acc:HGNC:5360]	None	DBD and Full	Yes	None	ID-proteins seems to lack the ability to bind DNA and presumably works as an inhibitor that sequesters TCF3 and other bHLH factors	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:2156629;11234019	Yes	1a2, Orthologous HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000125968#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000125968#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15138269	$#ENSP00000365280#ENSG00000125968#ENST00000376112#bHLH#$#ENSP00000365273#ENSG00000125968#ENST00000376105#bHLH#	FALSE
88	ENSG00000115738	ID2	bHLH	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination	IPR011598;	3398	inhibitor of DNA binding 2, HLH protein [Source:HGNC Symbol;Acc:HGNC:5361]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__DNA Binding_PMIDS:1922066;7565756	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000115738#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14627819	$#ENSP00000385465#ENSG00000115738#ENST00000331129#bHLH#$#ENSP00000379585#ENSG00000115738#ENST00000396290#bHLH#$#ENSP00000234091#ENSG00000115738#ENST00000234091#bHLH#	FALSE
89	ENSG00000117318	ID3	bHLH	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination	IPR011598;	3399	inhibitor of DNA binding 3, HLH protein [Source:HGNC Symbol;Acc:HGNC:5362]	None	DBD and Full	Yes	None	ID-proteins seems to lack the ability to bind DNA and presumably works as an inhibitor that sequesters TCF3 and other bHLH factors	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:15016815	Yes	1a2, Orthologous HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000117318#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000117318#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14627819	$#ENSP00000363689#ENSG00000117318#ENST00000374561#bHLH#	FALSE
90	ENSG00000172201	ID4	bHLH	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination	IPR011598;	3400	inhibitor of DNA binding 4, HLH protein [Source:HGNC Symbol;Acc:HGNC:5363]	None	DBD and Full	Yes	None	Cell paper data is probably contamination, these should be transcriptional inhibitors that sequester bHLH proteins by making heterodimers that wont bind DNA. Possibly a contaminated HT-SELEX-experiment or reflect binding specificity of a binding part	c	Yes	TF Gene Candidate__Transactivation_PMIDS:7665172;8139914	No	3a, decent circumstantial evidence for its role as	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000367972#ENSG00000172201#ENST00000378700#bHLH#	FALSE
91	ENSG00000104903	LYL1	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	TAL1, TAL2 and LYL are very similar and have a basic region with a bulky tryptophan inserting into the cluster of the basic residues. Binds DNA as a heterodimer with TCF3 (PDB:2YPB and PDB:2YPA).	IPR011598;	4066	lymphoblastic leukemia associated hematopoiesis regulator 1 [Source:HGNC Symbol;Acc:HGNC:6734]	None	DBD and Full	Yes	None	PMID:8628307 LYL1 makes heterodimer with TCF3	a	Yes	No	Yes	1a2, Orthologous HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000104903#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000264824#ENSG00000104903#ENST00000264824#bHLH#$#ENSP00000468122#ENSG00000104903#ENST00000590974#bHLH#	FALSE
92	ENSG00000125952	MAX	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	4149	MYC associated factor X [Source:HGNC Symbol;Acc:HGNC:6913]	1AN2	DBD and Full	Yes	None	Structure is a homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8265351	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000125952#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000246163#ENSG00000125952#ENST00000246163#bHLH#$#ENSP00000284165#ENSG00000125952#ENST00000284165#bHLH#$#ENSP00000351175#ENSG00000125952#ENST00000358402#bHLH#$#ENSP00000351490#ENSG00000125952#ENST00000358664#bHLH#$#ENSP00000452286#ENSG00000125952#ENST00000555667#bHLH#$#ENSP00000480127#ENSG00000125952#ENST00000618858#bHLH#$#ENSP00000342482#ENSG00000125952#ENST00000341653#bHLH#$#ENSP00000450818#ENSG00000125952#ENST00000556443#bHLH#$#ENSP00000452378#ENSG00000125952#ENST00000556979#bHLH#$#ENSP00000450955#ENSG00000125952#ENST00000557277#bHLH#	FALSE
93	ENSG00000166823	MESP1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	55897	mesoderm posterior bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:29658]	None	DBD	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000166823#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000166823#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18297060	$#ENSP00000300057#ENSG00000166823#ENST00000300057#bHLH#	FALSE
94	ENSG00000188095	MESP2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	145873	mesoderm posterior bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:29659]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16728472	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000342392#ENSG00000188095#ENST00000341735#bHLH#$#ENSP00000452998#ENSG00000188095#ENST00000560219#bHLH#	FALSE
95	ENSG00000187098	MITF	bHLH	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	Binds DNA both as homo- and heterodimers (PMID: 23207919). The structure 4ATI is a homodimer with DNA GTTAGCACATGACCCT.	IPR011598;IPR021802	4286	melanogenesis associated transcription factor [Source:HGNC Symbol;Acc:HGNC:7105]	4ATI	DBD and Full	Yes	None	Based on pmid:23207919, it binds DNA both as homo- and heterodimers, The structure 4ATI is homodimer with DNA GTTAGCACATGACCCT	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14737107;15716956	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000187098#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14737107, PMID:20530484 | IMP - PMID:14$#ENSG00000187098#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#NAS - PMID:24769727	$#ENSP00000324246#ENSG00000187098#ENST00000314557#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000295600#ENSG00000187098#ENST00000352241#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000481286#ENSG00000187098#ENST00000394348#bHLH#MITF_TFEB_C_3_N$#ENSP00000377880#ENSG00000187098#ENST00000394351#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000391276#ENSG00000187098#ENST00000457080#bHLH#MITF_TFEB_C_3_N$#ENSP00000435909#ENSG00000187098#ENST00000531774#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000324443#ENSG00000187098#ENST00000314589#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000418845#ENSG00000187098#ENST00000472437#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000411389#ENSG00000187098#ENST00000433517#bHLH#MITF_TFEB_C_3_N	FALSE
96	ENSG00000108788	MLX	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6945	MLX, MAX dimerization protein [Source:HGNC Symbol;Acc:HGNC:11645]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10918583;14742444	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000108788#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:10918583 | IMP - PMID:10918583$#ENSG00000108788#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10918583	$#ENSP00000246912#ENSG00000108788#ENST00000246912#bHLH#$#ENSP00000320913#ENSG00000108788#ENST00000346833#bHLH#$#ENSP00000416627#ENSG00000108788#ENST00000435881#bHLH#$#ENSP00000464697#ENSG00000108788#ENST00000591024#bHLH#	FALSE
97	ENSG00000175727	MLXIP	bHLH	Yes	Inferred motif	Obligate heteromer	High-throughput in vitro	None	None	IPR011598;	22877	MLX interacting protein [Source:HGNC Symbol;Acc:HGNC:17055]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000175727#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000312834#ENSG00000175727#ENST00000319080#bHLH#$#ENSP00000440769#ENSG00000175727#ENST00000538698#bHLH#$#ENSP00000438206#ENSG00000175727#ENST00000535430#bHLH#$#ENSP00000444507#ENSG00000175727#ENST00000542417#bHLH#$#ENSP00000445891#ENSG00000175727#ENST00000366272#bHLH#	FALSE
98	ENSG00000009950	MLXIPL	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	51085	MLX interacting protein like [Source:HGNC Symbol;Acc:HGNC:12744]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific__PMIDS:0	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000009950#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000009950#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:10780788	$#ENSP00000320886#ENSG00000009950#ENST00000313375#bHLH#$#ENSP00000346629#ENSG00000009950#ENST00000354613#bHLH#$#ENSP00000412330#ENSG00000009950#ENST00000414749#bHLH#$#ENSP00000406296#ENSG00000009950#ENST00000429400#bHLH#$#ENSP00000392636#ENSG00000009950#ENST00000434326#bHLH#	FALSE
99	ENSG00000070444	MNT	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Prefers to heterodimerize with MAX over homodimer formation (PMID: 9000049).	IPR011598;	4335	MAX network transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:7188]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9184233	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000070444#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9184233$#ENSG00000070444#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9184233	$#ENSP00000174618#ENSG00000070444#ENST00000174618#bHLH#$#ENSP00000476269#ENSG00000070444#ENST00000575394#bHLH#	FALSE
100	ENSG00000178860	MSC	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	9242	musculin [Source:HGNC Symbol;Acc:HGNC:7321]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9892671	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000178860#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000178860#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9584154	$#ENSP00000321445#ENSG00000178860#ENST00000325509#bHLH#	FALSE
101	ENSG00000151379	MSGN1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	343930	mesogenin 1 [Source:HGNC Symbol;Acc:HGNC:14907]	None	DBD	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000151379#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000281047#ENSG00000151379#ENST00000281047#bHLH#	FALSE
102	ENSG00000059728	MXD1	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).	IPR011598;	4084	MAX dimerization protein 1 [Source:HGNC Symbol;Acc:HGNC:6761]	1NLW	DBD and Full	Yes	Obligate_Multimer	Structure has MXD1-MAX heterodimer; PMID:12553908 for MXD1-MAX heterodimer 1NLW	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:8816491	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000059728#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10723141$#ENSG00000059728#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7829091, PMID:8425218	$#ENSP00000264444#ENSG00000059728#ENST00000264444#bHLH#$#ENSP00000443935#ENSG00000059728#ENST00000540449#bHLH#$#ENSP00000410672#ENSG00000059728#ENST00000435990#bHLH#	FALSE
103	ENSG00000213347	MXD3	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).	IPR011598;	83463	MAX dimerization protein 3 [Source:HGNC Symbol;Acc:HGNC:14008]	None	DBD	Yes	Obligate_Multimer	heterodimerizes with MAX	a	Yes	No	No	3a, decent circumstantial evidence for its role as	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000401867#ENSG00000213347#ENST00000439742#bHLH#$#ENSP00000389716#ENSG00000213347#ENST00000423571#bHLH#$#ENSP00000416921#ENSG00000213347#ENST00000427908#bHLH#$#ENSP00000425029#ENSG00000213347#ENST00000502529#bHLH#	FALSE
104	ENSG00000123933	MXD4	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).	IPR011598;	100616358	MAX dimerization protein 4 [Source:HGNC Symbol;Acc:HGNC:13906]	None	DBD and Full	Yes	None	heterodimerizes with MAX	a	Yes	No	No	3a, decent circumstantial evidence for its role as	Tim Hughes	Arttu Jolma	Yes	None	$#ENSP00000337889#ENSG00000123933#ENST00000337190#bHLH#Myc-LZ	FALSE
105	ENSG00000119950	MXI1	bHLH	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Has a putative AT-hook	Obligate heteromer (PMID: 8425219).	IPR011598;	4601	MAX interactor 1, dimerization protein [Source:HGNC Symbol;Acc:HGNC:7534]	None	DBD and Full	Yes	Obligate_Multimer	PMID:8425219, Heterodimerizes with MAX	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8425219;15467743	No	2a1, Lower confidence direct evidence	Yimeng Yin	Matt Weirauch	Yes	None	$#ENSP00000239007#ENSG00000119950#ENST00000239007#bHLH#$#ENSP00000331152#ENSG00000119950#ENST00000332674#bHLH#$#ENSP00000354606#ENSG00000119950#ENST00000361248#bHLH#$#ENSP00000376842#ENSG00000119950#ENST00000393134#bHLH#$#ENSP00000358625#ENSG00000119950#ENST00000369612#bHLH#	FALSE
106	ENSG00000136997	MYC	bHLH	Yes	Known motif	Obligate heteromer	In vivo/Misc source	None	Functions as a heterodimer with MAX.	IPR002418;IPR003327;IPR011598;IPR012682	4609	v-myc avian myelocytomatosis viral oncogene homolog [Source:HGNC Symbol;Acc:HGNC:7553]	1NKP	DBD and Full	Yes	Obligate_Multimer	Structure has MYC-MAX heterodimer; PMID:12553908 for MYC-MAX crystal structure, well established to make heterodimers with bHLH:s such as MAX	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12177005;16287840;16767079	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000136997#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10723141$#ENSG00000136997#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9924025	$#ENSP00000259523#ENSG00000136997#ENST00000259523#bHLH#Myc_N$#ENSP00000367207#ENSG00000136997#ENST00000377970#bHLH#Myc_N, TRH$#ENSP00000429441#ENSG00000136997#ENST00000517291#bHLH#Myc_N$#ENSP00000430235#ENSG00000136997#ENST00000524013#bHLH#Myc_N, TRH$#ENSP00000479618#ENSG00000136997#ENST00000613283#bHLH#Myc_N, TRH$#ENSP00000478887#ENSG00000136997#ENST00000621592#bHLH#Myc_N, TRH$#ENSP00000430226#ENSG00000136997#ENST00000520751#bHLH#	FALSE
107	ENSG00000116990	MYCL	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Similar to MYC and thus likely to functions as a heterodimer with MAX.	IPR002418;IPR011598;IPR012682;	4610	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog [Source:HGNC Symbol;Acc:H	None	DBD and Full	Yes	None	Mycn ChIP-seq makes sense, likely makes a heterodimer with MAX lice MYC	b	Yes	No	No	2a2, orthologous lower confidence evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000116990#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000361902#ENSG00000116990#ENST00000372815#bHLH#Myc_N$#ENSP00000380494#ENSG00000116990#ENST00000397332#bHLH#Myc_N$#ENSP00000361903#ENSG00000116990#ENST00000372816#bHLH#Myc_N$#ENSP00000434375#ENSG00000116990#ENST00000450953#bHLH#Myc_N	FALSE
108	ENSG00000134323	MYCN	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002418;IPR011598;IPR012682;	4613	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog [Source:HGNC Symbol;Acc:HG	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17124508	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000134323#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000281043#ENSG00000134323#ENST00000281043#bHLH#CENP-B_dimeris, LRS4, Myc_N	FALSE
109	ENSG00000111049	MYF5	bHLH	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR002546;IPR011598;IPR022032;	4617	myogenic factor 5 [Source:HGNC Symbol;Acc:HGNC:7565]	None	DBD and Full	Yes	Obligate_Multimer	PMID:16099183, heterodimerizes with TCF3, TCF4 and TCF12	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2385294;15497153	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000111049#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000111049#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:2311584	$#ENSP00000228644#ENSG00000111049#ENST00000228644#bHLH#Basic, Myf5	FALSE
110	ENSG00000111046	MYF6	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002546;IPR011598	4618	myogenic factor 6 [Source:HGNC Symbol;Acc:HGNC:7566]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1317551;2311584;11076940	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000111046#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000111046#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2311584$#ENSG00000111046#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000228641#ENSG00000111046#ENST00000228641#bHLH#Basic, Myf5	FALSE
111	ENSG00000129152	MYOD1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002546;IPR011598;IPR022032;	4654	myogenic differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7611]	1MDY	DBD and Full	Yes	None	Structure is MYOD1 homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12242286	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000129152#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11076940$#ENSG00000129152#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:1846704	$#ENSP00000250003#ENSG00000129152#ENST00000250003#bHLH#Basic, Myf5	FALSE
112	ENSG00000122180	MYOG	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002546;IPR011598	4656	myogenin [Source:HGNC Symbol;Acc:HGNC:7612]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10733231	Yes	1a1, Direct HQ evidence	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000122180#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000122180#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11076940 | TAS - PMID:19783823$#ENSG00000122180#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000122180#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000241651#ENSG00000122180#ENST00000241651#bHLH#Basic	FALSE
113	ENSG00000084676	NCOA1	bHLH	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif.  All are co-activators, collectively suggesting they might be obligate heteromers.	IPR000014;IPR009110;IPR010011;IPR011598;IPR013767;IPR014920;IPR014935;IPR017426	8648	nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:7668]	None	DBD and Full	Yes	None	None	c	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9192892	No	4a, two or more datasets predict it as a TF	Tim Hughes	Sam Lambert	Yes	None	$#ENSP00000288599#ENSG00000084676#ENST00000288599#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000320940#ENSG00000084676#ENST00000348332#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000379197#ENSG00000084676#ENST00000395856#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000385195#ENSG00000084676#ENST00000407230#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS_11,	FALSE
114	ENSG00000140396	NCOA2	bHLH	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif.  All are co-activators, collectively suggesting they might be obligate heteromers.	IPR000014;IPR009110;IPR010011;IPR011598;IPR013767;IPR014920;IPR014935;IPR017426	10499	nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:HGNC:7669]	3DZU	DBD and Full	Yes	None	The crystal has only a small peptide fragment of NCOA2	x	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14662770;15983373	No	3a, decent circumstantial evidence for its role as	Matt Weirauch	Arttu Jolma	Yes	None	$#ENSP00000399968#ENSG00000140396#ENST00000452400#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000429132#ENSG00000140396#ENST00000518363#bHLH#DUF1518, Nuc_rec_co-act$#ENSP00000430850#ENSG00000140396#ENST00000520416#bHLH#$#ENSP00000430348#ENSG00000140396#ENST00000519724#bHLH#	FALSE
115	ENSG00000124151	NCOA3	bHLH	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	NCOA1/2/3 all have been tested on PBMs and HT-SELEX without yielding a motif.  All are co-activators, collectively suggesting they might be obligate heteromers.	IPR000014;IPR009110;IPR010011;IPR011598;IPR013767;IPR014920;IPR014935;IPR017426	8202	nuclear receptor coactivator 3 [Source:HGNC Symbol;Acc:HGNC:7670]	None	DBD and Full	Yes	None	None	c	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9192892	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000361065#ENSG00000124151#ENST00000371997#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000361066#ENSG00000124151#ENST00000371998#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA$#ENSP00000361073#ENSG00000124151#ENST00000372004#bHLH#DUF1518, DUF4927, NCOA_u2, Nuc_rec_co-act, PAS, PA	FALSE
116	ENSG00000162992	NEUROD1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR016637;IPR022575;	4760	neuronal differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7762]	2QL2	DBD and Full	Yes	None	Structure is heterodimer NEUROD1 - TCF3	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9111329;9343431	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000162992#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000162992#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10545951$#ENSG00000162992#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14752053	$#ENSP00000295108#ENSG00000162992#ENST00000295108#bHLH#DNA_pol_phi, Neuro_bHLH	FALSE
117	ENSG00000171532	NEUROD2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR016637;IPR022575;	4761	neuronal differentiation 2 [Source:HGNC Symbol;Acc:HGNC:7763]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8816493;10098882;10871374	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000171532#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000171532#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8816493$#ENSG00000171532#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000306754#ENSG00000171532#ENST00000302584#bHLH#Neuro_bHLH	FALSE
118	ENSG00000123307	NEUROD4	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR016637;IPR022575;	58158	neuronal differentiation 4 [Source:HGNC Symbol;Acc:HGNC:13802]	None	DBD and Full	Yes	None	NEUROD1 makes heterodimer with TCF3 (PDB:2QL2), maybe the other NEURO:s do the same	b	Yes	TF Gene Candidate__Co-activation; Transactivation_PMIDS:12947105	No	1a2, Orthologous HQ evidence	Yimeng Yin	Matt Weirauch	Yes	None	$#ENSP00000242994#ENSG00000123307#ENST00000242994#bHLH#Neuro_bHLH	FALSE
119	ENSG00000164600	NEUROD6	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR016637;IPR022575;	63974	neuronal differentiation 6 [Source:HGNC Symbol;Acc:HGNC:13804]	None	DBD and Full	Yes	None	NEUROD1 makes heterodimer with TCF3 (PDB:2QL2), maybe the other NEURO:s do the same	a	Yes	TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:9308961;9454850;12562512	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000164600#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000297142#ENSG00000164600#ENST00000297142#bHLH#Neuro_bHLH	FALSE
120	ENSG00000181965	NEUROG1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	4762	neurogenin 1 [Source:HGNC Symbol;Acc:HGNC:7764]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:10814830	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000181965#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8816493$#ENSG00000181965#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000317580#ENSG00000181965#ENST00000314744#bHLH#	FALSE
121	ENSG00000178403	NEUROG2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	63973	neurogenin 2 [Source:HGNC Symbol;Acc:HGNC:13805]	None	DBD and Full	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000178403#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000317333#ENSG00000178403#ENST00000313341#bHLH#	FALSE
122	ENSG00000122859	NEUROG3	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	50674	neurogenin 3 [Source:HGNC Symbol;Acc:HGNC:13806]	None	DBD and Full	Yes	None	PMID:19389376 Ascl1 and Neurog2 make DNA-binding complexes, maybe this paralog behaves like it	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10757813;16511571;10757813;16511571;16511571;14576336;16511571	Yes	1a2, Orthologous HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000122859#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000122859#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14576336$#ENSG00000122859#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000242462#ENSG00000122859#ENST00000242462#bHLH#	FALSE
123	ENSG00000171786	NHLH1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	4807	nescient helix-loop-helix 1 [Source:HGNC Symbol;Acc:HGNC:7817]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000171786#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:12878195	$#ENSP00000302189#ENSG00000171786#ENST00000302101#bHLH#	FALSE
124	ENSG00000177551	NHLH2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	4808	nescient helix-loop-helix 2 [Source:HGNC Symbol;Acc:HGNC:7818]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15470499	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000177551#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000177551#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:16314316	$#ENSP00000322087#ENSG00000177551#ENST00000320238#bHLH#$#ENSP00000405062#ENSG00000177551#ENST00000429731#bHLH#$#ENSP00000358519#ENSG00000177551#ENST00000369506#bHLH#	FALSE
125	ENSG00000130751	NPAS1	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Likely obligate heteromer (PMID: 27782878).	IPR000014;IPR011598;IPR013655;IPR013767	4861	neuronal PAS domain protein 1 [Source:HGNC Symbol;Acc:HGNC:7894]	None	DBD and Full	Yes	None	Taipale lab has an unpublished PWM	a	Yes	TF Gene_DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:15635607	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000130751#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000130751#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9012850	$#ENSP00000405290#ENSG00000130751#ENST00000449844#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000469142#ENSG00000130751#ENST00000602212#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000398689#ENSG00000130751#ENST00000439365#bHLH#PAS_11, PAS_3	FALSE
126	ENSG00000170485	NPAS2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000014;IPR001067;IPR001610;IPR011598;IPR013767;	4862	neuronal PAS domain protein 2 [Source:HGNC Symbol;Acc:HGNC:7895]	None	DBD and Full	Yes	None	PMID:10864977 ARNTL2 Forms heterodimer with NPAS2	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11441146	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000170485#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000338283#ENSG00000170485#ENST00000335681#bHLH#PAS, PAS_11, PAS_3, PAS_9$#ENSP00000397595#ENSG00000170485#ENST00000427413#bHLH#PAS, PAS_9$#ENSP00000395265#ENSG00000170485#ENST00000451740#bHLH#PAS$#ENSP00000392125#ENSG00000170485#ENST00000450763#bHLH#	FALSE
127	ENSG00000151322	NPAS3	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Likely obligate heteromer (PMID: 9374395; PMID: 27782878).	IPR000014;IPR011598;IPR013655;IPR013767	64067	neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]	None	DBD	Yes	None	None	c	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:16172381;9374395;16172381;10534623;16172381;16190882	Yes	1a2, Orthologous HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000151322#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000319610#ENSG00000151322#ENST00000346562#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000348460#ENSG00000151322#ENST00000356141#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000350446#ENSG00000151322#ENST00000357798#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000449542#ENSG00000151322#ENST00000547068#bHLH#PAS, PAS_3$#ENSP00000448916#ENSG00000151322#ENST00000548645#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9$#ENSP00000447213#ENSG00000151322#ENST00000551008#bHLH#PAS, PAS_3$#ENSP00000446700#ENSG00000151322#ENST00000546849#bHLH#PAS	FALSE
128	ENSG00000174576	NPAS4	bHLH	Yes	Inferred motif	Obligate heteromer	High-throughput in vitro	None	Likely dimerizes with ARNT2 (PMID:24263188).	IPR000014;IPR011598;IPR013655;	266743	neuronal PAS domain protein 4 [Source:HGNC Symbol;Acc:HGNC:18983]	None	DBD	Yes	None	Taipale lab has an unpublished PWM; review suggests that it forms heterodimer with ARNT2 PMID:24263188, NPAS4:ARNT2	other	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701734	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000174576#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24465693$#ENSG00000174576#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14701734	$#ENSP00000311196#ENSG00000174576#ENST00000311034#bHLH#PAS, PAS_11, PAS_3	FALSE
129	ENSG00000184221	OLIG1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	116448	oligodendrocyte transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16983]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; TF PPI; Transactivation_PMIDS:18160645;15703389	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000414840#ENSG00000184221#ENST00000426947#bHLH#$#ENSP00000371785#ENSG00000184221#ENST00000382348#bHLH#	FALSE
130	ENSG00000205927	OLIG2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	OLIG2 can homodimerize and heterodimerize with OLIG1 and NGN2 (PMID:15655114; PMID: 21382552).	IPR011598;	10215	oligodendrocyte lineage transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:9398]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14576772;15655114	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000205927#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000371794#ENSG00000205927#ENST00000382357#bHLH#$#ENSP00000391183#ENSG00000205927#ENST00000430860#bHLH#$#ENSP00000331040#ENSG00000205927#ENST00000333337#bHLH#	FALSE
131	ENSG00000177468	OLIG3	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	167826	oligodendrocyte transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:18003]	None	DBD and Full	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0;	No	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000356708#ENSG00000177468#ENST00000367734#bHLH#	FALSE
132	ENSG00000168267	PTF1A	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	256297	pancreas specific transcription factor, 1a [Source:HGNC Symbol;Acc:HGNC:23734]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2294404;11279116	No	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000168267#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000365687#ENSG00000168267#ENST00000376504#bHLH#	FALSE
133	ENSG00000260428	SCX	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	SCX heterodimerizes with TCF3 (PMID: 19828133). The Taipale lab has an unpublished HT-SELEX model; both it and the inferred B1H motif seem very weak, supporting the idea that the homodimer does not bind DNA well.	IPR011598;	642658	scleraxis bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:32322]	None	not tested	not tested	None	Taipale lab has an unpublished PWM; PMID:19828133, SCX heterodimerizes with TCF3	x	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:10775504;15831523	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000260428#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000476384#ENSG00000260428#ENST00000567180#bHLH#	FALSE
134	ENSG00000112246	SIM1	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Similar to SIM2, which is a likely obligate heteromer.	IPR000014;IPR001610;IPR010578;IPR011598;IPR013655;IPR013767	6492	single-minded family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10882]	None	not tested	Yes	None	From review PMID:24263188, SIM1:ARNT2	other	Yes	No	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Tim Hughes	Yes	$#ENSG00000112246#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000112246#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8812055, PMID:9199934	$#ENSP00000262901#ENSG00000112246#ENST00000262901#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C$#ENSP00000358210#ENSG00000112246#ENST00000369208#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C	FALSE
135	ENSG00000159263	SIM2	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Likely obligate hetereomer (PMID: 7592839)	IPR000014;IPR001610;IPR010578;IPR011598;IPR013655;IPR013767	6493	single-minded family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10883]	None	DBD and Full	Yes	None	From review PMID:24263188, SIM2:ARNT2	other	Yes	TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11782478	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000159263#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000159263#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8661114, PMID:9199934	$#ENSP00000290399#ENSG00000159263#ENST00000290399#bHLH#PAS, PAS_11, PAS_3, PAS_9, SIM_C$#ENSP00000392003#ENSG00000159263#ENST00000431229#bHLH#PAS, PAS_11, PAS_3, PAS_4, PAS_9, SIM_C$#ENSP00000476273#ENSG00000159263#ENST00000483178#bHLH#PAS, PAS_11, PAS_3	FALSE
136	ENSG00000165643	SOHLH1	bHLH	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	Forms SOHLH1-SOHLH2 heterodimers (PMID: 22056784).	IPR011598;	402381	spermatogenesis and oogenesis specific basic helix-loop-helix 1 [Source:HGNC Symbol;Acc:HGNC:27845]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000165643#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000298466#ENSG00000165643#ENST00000298466#bHLH#$#ENSP00000404438#ENSG00000165643#ENST00000425225#bHLH#	FALSE
137	ENSG00000120669	SOHLH2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	54937	spermatogenesis and oogenesis specific basic helix-loop-helix 2 [Source:HGNC Symbol;Acc:HGNC:26026]	None	DBD	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Pratyush Das	Yes	$#ENSG00000120669#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000326838#ENSG00000120669#ENST00000317764#bHLH#$#ENSP00000369210#ENSG00000120669#ENST00000379881#bHLH#	FALSE
138	ENSG00000072310	SREBF1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6720	sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11289]	1AM9	DBD	Yes	None	Structure is homodimer with the non E-box site	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11829742	Yes	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000072310#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000072310#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16407292	$#ENSP00000261646#ENSG00000072310#ENST00000261646#bHLH#$#ENSP00000348069#ENSG00000072310#ENST00000355815#bHLH#$#ENSP00000379106#ENSG00000072310#ENST00000395757#bHLH#$#ENSP00000411516#ENSG00000072310#ENST00000423161#bHLH#$#ENSP00000466453#ENSG00000072310#ENST00000486311#bHLH#	FALSE
139	ENSG00000198911	SREBF2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6721	sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7903453	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000198911#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15358760	$#ENSP00000354476#ENSG00000198911#ENST00000361204#bHLH#$#ENSP00000412287#ENSG00000198911#ENST00000435061#bHLH#$#ENSP00000484441#ENSG00000198911#ENST00000612482#bHLH#	FALSE
140	ENSG00000162367	TAL1	bHLH	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	No motif yielded from PBMs or HT-SELEX. Binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA).	IPR011598;	6886	T-cell acute lymphocytic leukemia 1 [Source:HGNC Symbol;Acc:HGNC:11556]	2YPB	DBD	Yes	Obligate_Multimer	Obligate heterodimer with TCF3 pmid:23831025	b	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:8016094;8289805	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000162367#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000162367#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19497860	$#ENSP00000294339#ENSG00000162367#ENST00000294339#bHLH#$#ENSP00000360951#ENSG00000162367#ENST00000371884#bHLH#	FALSE
141	ENSG00000186051	TAL2	bHLH	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	No motif yielded from PBMs or HT-SELEX. Similar to TAL1, which binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA).	IPR011598;	6887	T-cell acute lymphocytic leukemia 2 [Source:HGNC Symbol;Acc:HGNC:11557]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8152805;11071772	Yes	2a2, orthologous lower confidence evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000186051#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000334547#ENSG00000186051#ENST00000334077#bHLH#	FALSE
142	ENSG00000140262	TCF12	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6938	transcription factor 12 [Source:HGNC Symbol;Acc:HGNC:11623]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8163514;12826747	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000140262#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11802795$#ENSG00000140262#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11802795	$#ENSP00000267811#ENSG00000140262#ENST00000267811#bHLH#$#ENSP00000331057#ENSG00000140262#ENST00000333725#bHLH#$#ENSP00000342459#ENSG00000140262#ENST00000343827#bHLH#$#ENSP00000440017#ENSG00000140262#ENST00000543579#bHLH#$#ENSP00000453737#ENSG00000140262#ENST00000557843#bHLH#$#ENSP00000444696#ENSG00000140262#ENST00000537840#bHLH#$#ENSP00000453876#ENSG00000140262#ENST00000559609#bHLH#$#ENSP00000453264#ENSG00000140262#ENST00000559710#bHLH#$#ENSP00000456280#ENSG00000140262#ENST00000560948#bHLH#$#ENSP00000454823#ENSG00000140262#ENST00000560836#bHLH#	FALSE
143	ENSG00000125878	TCF15	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6939	transcription factor 15 (basic helix-loop-helix) [Source:HGNC Symbol;Acc:HGNC:11627]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: non-sequence-specific_DNA Binding_PMIDS:7597044	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000125878#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8041747, PMID:8825648	$#ENSP00000246080#ENSG00000125878#ENST00000246080#bHLH#	FALSE
144	ENSG00000118526	TCF21	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6943	transcription factor 21 [Source:HGNC Symbol;Acc:HGNC:11632]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000118526#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000118526#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12493738	$#ENSP00000237316#ENSG00000118526#ENST00000237316#bHLH#$#ENSP00000356857#ENSG00000118526#ENST00000367882#bHLH#	FALSE
145	ENSG00000163792	TCF23	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Basic region is very similar to TCF21, which binds DNA as a homodimer in HT-SELEX.	IPR011598;	150921	transcription factor 23 [Source:HGNC Symbol;Acc:HGNC:18602]	None	DBD and Full	Yes	None	Taipale lab has an unpublished PWM; PMID:10652346 Suggests that similarly to ID-proteins it seems to lack the ability to bind DNA and presumably works as an inhibitor that sequesters TCF3	c	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000296096#ENSG00000163792#ENST00000296096#bHLH#	FALSE
146	ENSG00000261787	TCF24	bHLH	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	None	100129654	Transcription factor 24 [Source:HGNC Symbol;Acc:HGNC:32275]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000455444#ENSG00000261787#ENST00000563496#bHLH#	FALSE
147	ENSG00000071564	TCF3	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6929	transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633]	2QL2	DBD and Full	Yes	None	Structure is heterodimer NEUROD1 - TCF3	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14627819	Yes	1a1, Direct HQ evidence	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000071564#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14576336$#ENSG00000071564#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:2105528 | NAS - PMID:2493990$#ENSG00000071564#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14752053	$#ENSP00000262965#ENSG00000071564#ENST00000262965#bHLH#$#ENSP00000480564#ENSG00000071564#ENST00000611869#bHLH#$#ENSP00000465510#ENSG00000071564#ENST00000585731#bHLH#$#ENSP00000467508#ENSG00000071564#ENST00000587425#bHLH#$#ENSP00000468487#ENSG00000071564#ENST00000588136#bHLH#$#ENSP00000468481#ENSG00000071564#ENST00000593064#bHLH#$#ENSP00000466954#ENSG00000071564#ENST00000586318#bHLH#$#ENSP00000466565#ENSG00000071564#ENST00000590684#bHLH#	FALSE
148	ENSG00000196628	TCF4	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	6925	transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11634]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8978694	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000196628#GO:0001011#sequence-specific DNA binding RNA polymerase recruiting transcription factor activity#ISS - PMID:8978694$#ENSG00000196628#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - PMID:8978694$#ENSG00000196628#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11802795, PMID:2105528	$#ENSP00000348374#ENSG00000196628#ENST00000356073#bHLH#$#ENSP00000381382#ENSG00000196628#ENST00000398339#bHLH#$#ENSP00000409447#ENSG00000196628#ENST00000457482#bHLH#$#ENSP00000439656#ENSG00000196628#ENST00000543082#bHLH#$#ENSP00000457765#ENSG00000196628#ENST00000561831#bHLH#$#ENSP00000455450#ENSG00000196628#ENST00000562543#bHLH#$#ENSP00000456802#ENSG00000196628#ENST00000562638#bHLH#$#ENSP00000455261#ENSG00000196628#ENST00000564228#bHLH#$#ENSP00000455418#ENSG00000196628#ENST00000566286#bHLH#$#ENSP00000454366#ENSG00000196628#ENST00000567880#bHLH#$#ENSP00000455763#ENSG00000196628#ENST00000570287#bHLH#$#ENSP00000440731#ENSG00000196628#ENST00000537578#bHLH#$#ENSP00000439827#ENSG00000196628#ENST00000537856#bHLH#$#ENSP00000445202#ENSG00000196628#ENST00000540999#bHLH#$#ENSP00000441562#ENSG00000196628#ENST00000544241#bHLH#$#ENSP00000455179#ENSG00000196628#ENST00000561992#bHLH#$#ENSP00000458122#ENSG00000196628#ENST00000568186#bHLH#$#ENSP00000468729#ENSG00000196628#ENST00000570146#bHLH#$#ENSP00000454647#ENSG00000196628#ENST00000570177#bHLH#$#ENSP00000487505#ENSG00000196628#ENST00000626631#bHLH#$#ENSP00000486974#ENSG00000196628#ENST00000630828#bHLH#$#ENSP00000454866#ENSG00000196628#ENST00000562847#bHLH#$#ENSP00000454584#ENSG00000196628#ENST00000565908#bHLH#$#ENSP00000456983#ENSG00000196628#ENST00000566514#bHLH#$#ENSP00000487419#ENSG00000196628#ENST00000630712#bHLH#$#ENSP00000490451#ENSG00000196628#ENST00000635822#bHLH#$#ENSP00000490006#ENSG00000196628#ENST00000636400#bHLH#$#ENSP00000490883#ENSG00000196628#ENST00000636822#bHLH#$#ENSP00000490832#ENSG00000196628#ENST00000637169#bHLH#$#ENSP00000490625#ENSG00000196628#ENST00000638154#bHLH#	FALSE
149	ENSG00000101190	TCFL5	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	10732	transcription factor like 5 [Source:HGNC Symbol;Acc:HGNC:11646]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000101190#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9763657	$#ENSP00000217162#ENSG00000101190#ENST00000217162#bHLH#$#ENSP00000334294#ENSG00000101190#ENST00000335351#bHLH#	FALSE
150	ENSG00000090447	TFAP4	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also can form heterodimers (PMID: 26550823).	IPR011598;	7023	transcription factor AP-4 (activating enhancer binding protein 4) [Source:HGNC Symbol;Acc:HGNC:11745	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2123466;2833704	Yes	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000090447#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000090447#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:2833704	$#ENSP00000204517#ENSG00000090447#ENST00000204517#bHLH#$#ENSP00000459390#ENSG00000090447#ENST00000572393#bHLH#	FALSE
151	ENSG00000068323	TFE3	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR021802	7030	transcription factor binding to IGHM enhancer 3 [Source:HGNC Symbol;Acc:HGNC:11752]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10707962;15994295	Yes	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	$#ENSG00000068323#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000314129#ENSG00000068323#ENST00000315869#bHLH#DUF3371, MITF_TFEB_C_3_N	FALSE
152	ENSG00000112561	TFEB	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR021802	7942	transcription factor EB [Source:HGNC Symbol;Acc:HGNC:11753]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000112561#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19556463 | NAS - PMID:2115126	$#ENSP00000230323#ENSG00000112561#ENST00000230323#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000351742#ENSG00000112561#ENST00000358871#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000362124#ENSG00000112561#ENST00000373033#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000383998#ENSG00000112561#ENST00000406563#bHLH#DUF3371$#ENSP00000396168#ENSG00000112561#ENST00000424495#bHLH#MITF_TFEB_C_3_N$#ENSP00000415035#ENSG00000112561#ENST00000425401#bHLH#MITF_TFEB_C_3_N$#ENSP00000415946#ENSG00000112561#ENST00000433032#bHLH#$#ENSP00000395208#ENSG00000112561#ENST00000445700#bHLH#$#ENSP00000343948#ENSG00000112561#ENST00000343317#bHLH#DUF3371, MITF_TFEB_C_3_N$#ENSP00000377824#ENSG00000112561#ENST00000394283#bHLH#MITF_TFEB_C_3_N$#ENSP00000400276#ENSG00000112561#ENST00000419574#bHLH#MITF_TFEB_C_3_N	FALSE
153	ENSG00000105967	TFEC	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;IPR021802	22797	transcription factor EC [Source:HGNC Symbol;Acc:HGNC:11754]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8336698	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000105967#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9256061	$#ENSP00000265440#ENSG00000105967#ENST00000265440#bHLH#DUF3371$#ENSP00000318676#ENSG00000105967#ENST00000320239#bHLH#DUF3371$#ENSP00000377125#ENSG00000105967#ENST00000393485#bHLH#$#ENSP00000417432#ENSG00000105967#ENST00000484212#bHLH#MITF_TFEB_C_3_N$#ENSP00000387650#ENSG00000105967#ENST00000457268#bHLH#DUF3371	FALSE
154	ENSG00000122691	TWIST1	bHLH	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Can form both homodimers and heterodimers with TCF3 (PMID: 16502419).	IPR011598;	7291	twist family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12428]	None	DBD	Yes	Obligate_Multimer	PMID: 16502419, reported to be able to make both homo- or heterodimers with TCF3	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12210745	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000122691#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17332325$#ENSG00000122691#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000242261#ENSG00000122691#ENST00000242261#bHLH#	FALSE
155	ENSG00000233608	TWIST2	bHLH	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR011598;	117581	twist family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:20670]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Other; TF PPI_PMIDS:11809751;14654692	No	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	None	$#ENSP00000405176#ENSG00000233608#ENST00000448943#bHLH#$#ENSP00000482581#ENSG00000233608#ENST00000612363#bHLH#	FALSE
156	ENSG00000158773	USF1	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR011598;	7391	upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593]	1AN4	DBD and Full	Yes	None	Structure is a homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9677331	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000158773#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:2249772 | IMP - PMID:18234320, PMID:857	$#ENSP00000356999#ENSG00000158773#ENST00000368020#bHLH#$#ENSP00000357000#ENSG00000158773#ENST00000368021#bHLH#$#ENSP00000433041#ENSG00000158773#ENST00000528768#bHLH#	FALSE
157	ENSG00000105698	USF2	bHLH	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR011598;	7392	upstream transcription factor 2, c-fos interacting [Source:HGNC Symbol;Acc:HGNC:12594]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15242350	Yes	1a1, Direct HQ evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000105698#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1589769, PMID:8954795$#ENSG00000105698#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IMP - PMID:8576131	$#ENSP00000222305#ENSG00000105698#ENST00000222305#bHLH#$#ENSP00000340633#ENSG00000105698#ENST00000343550#bHLH#$#ENSP00000368429#ENSG00000105698#ENST00000379134#bHLH#$#ENSP00000471511#ENSG00000105698#ENST00000594064#bHLH#$#ENSP00000469585#ENSG00000105698#ENST00000598058#bHLH#$#ENSP00000470081#ENSG00000105698#ENST00000599625#bHLH#$#ENSP00000471775#ENSG00000105698#ENST00000596380#bHLH#$#ENSP00000469364#ENSG00000105698#ENST00000599471#bHLH#	FALSE
158	ENSG00000176542	USF3	bHLH	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR011598;	205717	None	None	DBD	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000420752#ENSG00000176542#ENST00000491165#bHLH#$#ENSP00000320794#ENSG00000176542#ENST00000316407#bHLH#$#ENSP00000420721#ENSG00000176542#ENST00000478658#bHLH#	FALSE
159	ENSG00000143157	POGK	Brinker	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR004875;IPR006600;IPR009057;IPR018586;	57645	pogo transposable element with KRAB domain [Source:HGNC Symbol;Acc:HGNC:18800]	None	Full	Yes	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000356850#ENSG00000143157#ENST00000367876#Brinker#DDE_1, HTH_Tnp_Tc5, KRAB$#ENSP00000404402#ENSG00000143157#ENST00000449930#Brinker#KRAB$#ENSP00000356849#ENSG00000143157#ENST00000367875#Brinker#DDE_1, HTH_Tnp_Tc5, KRAB	FALSE
160	ENSG00000267281	AC023509.3	bZIP	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	Identical bZIP DBD to ATF7. Some isoforms also contain a single C2H2 ZF.  This is known to facilitate protein interactions in ATF7 (see ATF7 Uniprot page), so AC023509.3 is only classified here as a bZIP protein	None	None	Uncharacterized protein	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000267281#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$##ENSG00000267281##bZIP#	FALSE
161	ENSG00000115266	APC2	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding	IPR000225;IPR009223;IPR009224;IPR009234;IPR016024;IPR026831	10297	adenomatosis polyposis coli 2 [Source:HGNC Symbol;Acc:HGNC:24036]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000233607#ENSG00000115266#ENST00000233607#bZIP#APC_N_CC, APC_basic, APC_r, Arm, Arm_APC_u3, SAMP,$#ENSP00000238483#ENSG00000115266#ENST00000238483#bZIP#APC_N_CC, Arm, Arm_APC_u3, Suppressor_APC, ZapB$#ENSP00000442954#ENSG00000115266#ENST00000535453#bZIP#APC_N_CC, APC_basic, APC_r, Arm, Arm_APC_u3, SAMP,$#ENSP00000467073#ENSG00000115266#ENST00000590469#bZIP#APC_N_CC, Arm, Suppressor_APC, ZapB$#ENSP00000466173#ENSG00000115266#ENST00000590877#bZIP#Suppressor_APC	FALSE
162	ENSG00000123268	ATF1	bZIP	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001630;IPR003102;IPR004827;	466	activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	$#ENSG00000123268#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1655749$#ENSG00000123268#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2196176, PMID:8401579$#ENSG00000123268#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000262053#ENSG00000123268#ENST00000262053#bZIP#pKID$#ENSP00000448921#ENSG00000123268#ENST00000552487#bZIP#pKID$#ENSP00000448592#ENSG00000123268#ENST00000552510#bZIP#pKID	FALSE
163	ENSG00000115966	ATF2	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;IPR007087;IPR016378;	1386	activating transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:784]	1T2K	DBD and Full	Yes	None	Structure has IRF3;ATF2;JUN	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1658708;2529117;9139739;10909971	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000115966#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000115966#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000115966#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8798441$#ENSG00000115966#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IC - PMID:19861239$#ENSG00000115966#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341$#ENSG00000115966#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:10821277	$#ENSP00000264110#ENSG00000115966#ENST00000264110#bZIP#$#ENSP00000340576#ENSG00000115966#ENST00000345739#bZIP#$#ENSP00000376327#ENSG00000115966#ENST00000392544#bZIP#$#ENSP00000386282#ENSG00000115966#ENST00000409499#bZIP#$#ENSP00000386526#ENSG00000115966#ENST00000409833#bZIP#$#ENSP00000407911#ENSG00000115966#ENST00000426833#bZIP#	FALSE
164	ENSG00000162772	ATF3	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000837;IPR004827	467	activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11916968;12815047	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000162772#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000162772#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000162772#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000162772#GO:0003700#sequence-specific DNA binding transcription factor activity#IGI - PMID:24939851	$#ENSP00000336908#ENSG00000162772#ENST00000336937#bZIP#$#ENSP00000344352#ENSG00000162772#ENST00000341491#bZIP#$#ENSP00000355948#ENSG00000162772#ENST00000366981#bZIP#$#ENSP00000355950#ENSG00000162772#ENST00000366983#bZIP#$#ENSP00000355954#ENSG00000162772#ENST00000366987#bZIP#$#ENSP00000480606#ENSG00000162772#ENST00000613104#bZIP#	FALSE
165	ENSG00000128272	ATF4	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	468	activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15109498;16000305	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000128272#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IC - PMID:21113145 | IDA - PMID:11478948, PMID:128$#ENSG00000128272#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000128272#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | TAS - PMID:12689582	$#ENSP00000336790#ENSG00000128272#ENST00000337304#bZIP#$#ENSP00000379912#ENSG00000128272#ENST00000396680#bZIP#$#ENSP00000384587#ENSG00000128272#ENST00000404241#bZIP#	FALSE
166	ENSG00000169136	ATF5	bZIP	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac motifs dont correspond to canonical bZIP binding sites. Annotated as obligate heteromer based on peptide array studies (PMID:12805554).	IPR004827;	100616483	activating transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:790]	None	DBD and Full	Yes	Obligate_Multimer	pmid:12805554 has strong preference for forming heterodimers with CEBPG and other CEBP:s over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15735663;16164412	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000169136#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000169136#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000169136#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:20654631 | ISS - GO_REF:0000024	$#ENSP00000396954#ENSG00000169136#ENST00000423777#bZIP#$#ENSP00000470633#ENSG00000169136#ENST00000595125#bZIP#$#ENSP00000470464#ENSG00000169136#ENST00000596658#bZIP#$#ENSP00000471162#ENSG00000169136#ENST00000600336#bZIP#$#ENSP00000470978#ENSG00000169136#ENST00000597227#bZIP#	FALSE
167	ENSG00000118217	ATF6	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	22926	activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:9271374;14765107	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000118217#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11163209	$#ENSP00000356919#ENSG00000118217#ENST00000367942#bZIP#	FALSE
168	ENSG00000213676	ATF6B	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	1388	activating transcription factor 6 beta [Source:HGNC Symbol;Acc:HGNC:2349]	None	DBD	Yes	None	None	a	Yes	No	No	3a, decent circumstantial evidence for its role as	Sam Lambert	Pratyush Das	Yes	$#ENSG00000213676#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11256944	$#ENSP00000364347#ENSG00000213676#ENST00000375201#bZIP#$#ENSP00000364349#ENSG00000213676#ENST00000375203#bZIP#$#ENSP00000393419#ENSG00000213676#ENST00000453203#bZIP#	FALSE
169	ENSG00000170653	ATF7	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Some isoforms also contain a single C2H2 ZF.  This is known to facilitate protein interactions (see Uniprot page), so ATF7 is only classified here as a bZIP protein	IPR004827;IPR007087;IPR015880;IPR016378	11016	activating transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:792]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1694576;11278933;15735663;11278933;15735663	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000170653#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000399465#ENSG00000170653#ENST00000420353#bZIP#$#ENSP00000456858#ENSG00000170653#ENST00000548118#bZIP#$#ENSP00000465192#ENSG00000170653#ENST00000591397#bZIP#$#ENSP00000449938#ENSG00000170653#ENST00000548446#bZIP#	FALSE
170	ENSG00000156273	BACH1	bZIP	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000210;IPR004826;IPR004827;IPR008917;IPR011333;IPR013069	100379661	BTB domain and CNC homolog 1 [Source:HGNC Symbol;Acc:HGNC:935]	None	DBD and Full	Yes	None	pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10620011	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000156273#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12511571 | IMP - PMID:21555518$#ENSG00000156273#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000156273#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000156273#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000286800#ENSG00000156273#ENST00000286800#bZIP#BTB$#ENSP00000382805#ENSG00000156273#ENST00000399921#bZIP#BTB$#ENSP00000408605#ENSG00000156273#ENST00000447177#bZIP#BTB$#ENSP00000448663#ENSG00000156273#ENST00000547141#bZIP#$#ENSP00000447332#ENSG00000156273#ENST00000548219#bZIP#$#ENSP00000448982#ENSG00000156273#ENST00000548467#bZIP#$#ENSP00000449316#ENSG00000156273#ENST00000550131#bZIP#$#ENSP00000392202#ENSG00000156273#ENST00000435072#bZIP#BTB$#ENSP00000400576#ENSG00000156273#ENST00000451655#bZIP#BTB$#ENSP00000470673#ENSG00000156273#ENST00000468059#bZIP#$#ENSP00000449383#ENSG00000156273#ENST00000546469#bZIP#	FALSE
171	ENSG00000112182	BACH2	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Based on Newman et al 2003 (PMID: 12805554), the protein has strong preference for forming heterodimers with MAFG and MAFK over homo-dimerisation. The Homer ChIP-seq motif appears to be a MAF-BACH2 heterodimer.	IPR000210;IPR004826;IPR004827;IPR008917;IPR011333;IPR013069	60468	BTB domain and CNC homolog 2 [Source:HGNC Symbol;Acc:HGNC:14078]	None	DBD	Yes	None	pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8887638;10949928	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000112182#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000112182#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000257749#ENSG00000112182#ENST00000257749#bZIP#BTB$#ENSP00000437473#ENSG00000112182#ENST00000537989#bZIP#BTB$#ENSP00000384145#ENSG00000112182#ENST00000406998#bZIP#BTB	FALSE
172	ENSG00000156127	BATF	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Prefers to heterodimerize, but it has an HT-SELEX (homodimer) motif. Its homodimerization Kd is 184nM and its best heterodimer is with CEBPG (<1nM) (PMID: 23661758).	IPR000837;IPR004827	10538	basic leucine zipper ATF-like transcription factor [Source:HGNC Symbol;Acc:HGNC:958]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10777209;11466704	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000156127#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000156127#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000156127#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000286639#ENSG00000156127#ENST00000286639#bZIP#$#ENSP00000450486#ENSG00000156127#ENST00000555504#bZIP#	FALSE
173	ENSG00000168062	BATF2	bZIP	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	Part of AP-1 complex - there is no evidence it can bind on its own as a homodimer.	IPR004827;	116071	basic leucine zipper ATF-like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:25163]	None	DBD and Full	Yes	Obligate_Multimer	Heterodimerize with Jun and possible other bZIP proteins PMID:23787991	a	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000168062#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000301887#ENSG00000168062#ENST00000301887#bZIP#$#ENSP00000398911#ENSG00000168062#ENST00000435842#bZIP#$#ENSP00000434915#ENSG00000168062#ENST00000527716#bZIP#HALZ$#ENSP00000435640#ENSG00000168062#ENST00000534177#bZIP#	FALSE
174	ENSG00000123685	BATF3	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Transfac motif is dubious.	IPR000837;IPR004827	55509	basic leucine zipper ATF-like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:28915]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000123685#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15467742$#ENSG00000123685#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10878360	$#ENSP00000243440#ENSG00000123685#ENST00000243440#bZIP#	FALSE
175	ENSG00000188848	BEND4	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Lacks the basic region of the bZIP domain.	IPR018379;	389206	BEN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23815]	None	not tested	not tested	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000421169#ENSG00000188848#ENST00000502486#bZIP#BEN$#ENSP00000421160#ENSG00000188848#ENST00000504360#bZIP#$#ENSP00000478660#ENSG00000188848#ENST00000611697#bZIP#BEN	FALSE
176	ENSG00000151468	CCDC3	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	bZIP domain is truncated and lacks the DNA-contacting residues.	None	83643	coiled-coil domain containing 3 [Source:HGNC Symbol;Acc:HGNC:23813]	None	not tested	not tested	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000368102#ENSG00000151468#ENST00000378825#bZIP#DUF489, DUF812, DegS, KLRAQ, YscO$#ENSP00000368116#ENSG00000151468#ENST00000378839#bZIP#	FALSE
177	ENSG00000150676	CCDC83	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	bZIP domains are truncated, such that they are likely just coiled-coiled regions with no DNA-binding ability.	None	220047	coiled-coil domain containing 83 [Source:HGNC Symbol;Acc:HGNC:28535]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000344512#ENSG00000150676#ENST00000342404#bZIP#TSC22$#ENSP00000434373#ENSG00000150676#ENST00000526729#bZIP#$#ENSP00000280245#ENSG00000150676#ENST00000280245#bZIP#TSC22	FALSE
178	ENSG00000245848	CEBPA	bZIP	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR004827;IPR016468	1050	CCAAT/enhancer binding protein alpha [Source:HGNC Symbol;Acc:HGNC:1833]	1NWQ	not tested	Yes	None	Structure is a homodimer	No	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:2227417;8632009	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000245848#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000245848#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:16946298$#ENSG00000245848#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11242107, PMID:12695546, PMID:15664994$#ENSG00000245848#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#NAS - PMID:7575576	$#ENSP00000427514#ENSG00000245848#ENST00000498907#bZIP#	FALSE
179	ENSG00000172216	CEBPB	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;IPR016468	1051	CCAAT/enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834]	1GTW	DBD	Yes	None	Structure is a homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:15308669;15713650	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000172216#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172216#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10821850$#ENSG00000172216#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000305422#ENSG00000172216#ENST00000303004#bZIP#	FALSE
180	ENSG00000221869	CEBPD	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	CEBPD binds as both a homodimer and as a heterdimer with other C/EBP TFs (PMID: 1884998; PMID: 12805554).	IPR004827;IPR016468	1052	CCAAT/enhancer binding protein delta [Source:HGNC Symbol;Acc:HGNC:1835]	None	DBD	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8572170;16192306	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000221869#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000386165#ENSG00000221869#ENST00000408965#bZIP#	FALSE
181	ENSG00000092067	CEBPE	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also forms heterodimers.	IPR004827;IPR016468	1053	CCAAT/enhancer binding protein epsilon [Source:HGNC Symbol;Acc:HGNC:1836]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:9593684;10233885	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000092067#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10233885	$#ENSP00000206513#ENSG00000092067#ENST00000206513#bZIP#	FALSE
182	ENSG00000153879	CEBPG	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	1054	CCAAT/enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7501458;15833715	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000153879#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15833715$#ENSG00000153879#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - PMID:7501458$#ENSG00000153879#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:7665092	$#ENSP00000284000#ENSG00000153879#ENST00000284000#bZIP#$#ENSP00000466022#ENSG00000153879#ENST00000585933#bZIP#	FALSE
183	ENSG00000118260	CREB1	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001630;IPR003102;IPR004827;	1385	cAMP responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2345]	1DH3	DBD and Full	Yes	None	Structure is a homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14593102;15054091	Yes	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000118260#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000118260#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8798441$#ENSG00000118260#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:19861239	$#ENSP00000236995#ENSG00000118260#ENST00000353267#bZIP#pKID$#ENSP00000387699#ENSG00000118260#ENST00000432329#bZIP#pKID$#ENSP00000401803#ENSG00000118260#ENST00000455757#bZIP#$#ENSP00000391125#ENSG00000118260#ENST00000457101#bZIP#pKID	FALSE
184	ENSG00000107175	CREB3	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	10488	CAMP responsive element binding protein 3	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000107175#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16940180$#ENSG00000107175#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:16940180	$#ENSP00000342136#ENSG00000107175#ENST00000353704#bZIP#	FALSE
185	ENSG00000157613	CREB3L1	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001630;IPR004827	90993	cAMP responsive element binding protein 3 like 1 [Source:HGNC Symbol;Acc:HGNC:18856]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15665855;16236796	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000157613#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024	$#ENSP00000481956#ENSG00000157613#ENST00000621158#bZIP#$#ENSP00000436574#ENSG00000157613#ENST00000530518#bZIP#$#ENSP00000431677#ENSG00000157613#ENST00000534787#bZIP#	FALSE
186	ENSG00000182158	CREB3L2	bZIP	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR004827;	64764	cAMP responsive element binding protein 3 like 2 [Source:HGNC Symbol;Acc:HGNC:23720]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000182158#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000329140#ENSG00000182158#ENST00000330387#bZIP#$#ENSP00000410314#ENSG00000182158#ENST00000452463#bZIP#$#ENSP00000403550#ENSG00000182158#ENST00000456390#bZIP#$#ENSP00000402889#ENSG00000182158#ENST00000420629#bZIP#$#ENSP00000388917#ENSG00000182158#ENST00000458726#bZIP#	FALSE
187	ENSG00000060566	CREB3L3	bZIP	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Gel-shift and reporter experiments demonstrate that CREB3L3 is a TF (PMID: 11353085).	IPR004827;	84699	cAMP responsive element binding protein 3 like 3 [Source:HGNC Symbol;Acc:HGNC:18855]	None	not tested	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11353085	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Tim Hughes	Yes	$#ENSG00000060566#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11353085 | IMP - PMID:11353085	$#ENSP00000078445#ENSG00000060566#ENST00000078445#bZIP#$#ENSP00000469355#ENSG00000060566#ENST00000595923#bZIP#$#ENSP00000470119#ENSG00000060566#ENST00000602147#bZIP#$#ENSP00000472399#ENSG00000060566#ENST00000602257#bZIP#	FALSE
188	ENSG00000143578	CREB3L4	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;IPR008917	148327	cAMP responsive element binding protein 3 like 4 [Source:HGNC Symbol;Acc:HGNC:18854]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11956138;15938716	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000143578#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000271889#ENSG00000143578#ENST00000271889#bZIP#$#ENSP00000357589#ENSG00000143578#ENST00000368600#bZIP#$#ENSP00000357592#ENSG00000143578#ENST00000368603#bZIP#$#ENSP00000357596#ENSG00000143578#ENST00000368607#bZIP#$#ENSP00000357590#ENSG00000143578#ENST00000368601#bZIP#	FALSE
189	ENSG00000146592	CREB5	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;IPR007087;IPR016378;	9586	cAMP responsive element binding protein 5 [Source:HGNC Symbol;Acc:HGNC:16844]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000146592#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8378084	$#ENSP00000350359#ENSG00000146592#ENST00000357727#bZIP#$#ENSP00000379592#ENSG00000146592#ENST00000396298#bZIP#$#ENSP00000379593#ENSG00000146592#ENST00000396299#bZIP#$#ENSP00000379594#ENSG00000146592#ENST00000396300#bZIP#$#ENSP00000387197#ENSG00000146592#ENST00000409603#bZIP#$#ENSP00000394979#ENSG00000146592#ENST00000426500#bZIP#	FALSE
190	ENSG00000111269	CREBL2	bZIP	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	1389	cAMP responsive element binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:2350]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a2, Orthologous HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000111269#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000228865#ENSG00000111269#ENST00000228865#bZIP#	FALSE
191	ENSG00000164463	CREBRF	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Tested on HT-SELEX and did not yield a motif. Binds to CREB3 and represses the unfolded protein response (PMID: 18391022).	IPR004827;	153222	CREB3 regulatory factor [Source:HGNC Symbol;Acc:HGNC:24050]	None	DBD and Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000164463#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000296953#ENSG00000164463#ENST00000296953#bZIP#$#ENSP00000428290#ENSG00000164463#ENST00000520420#bZIP#$#ENSP00000431107#ENSG00000164463#ENST00000522692#bZIP#$#ENSP00000430801#ENSG00000164463#ENST00000523161#bZIP#	FALSE
192	ENSG00000137504	CREBZF	bZIP	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	58487	CREB/ATF bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:24905]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000137504#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002$#ENSG00000137504#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15705566	$#ENSP00000435980#ENSG00000137504#ENST00000534224#bZIP#$#ENSP00000433459#ENSG00000137504#ENST00000527447#bZIP#	FALSE
193	ENSG00000095794	CREM	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001630;IPR003102;IPR004827;	1390	cAMP responsive element modulator	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Tim Hughes	Yes	$#ENSG00000095794#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000341875#ENSG00000095794#ENST00000342105#bZIP#pKID$#ENSP00000265372#ENSG00000095794#ENST00000345491#bZIP#pKID$#ENSP00000345384#ENSG00000095794#ENST00000348787#bZIP#pKID$#ENSP00000346804#ENSG00000095794#ENST00000354759#bZIP#pKID$#ENSP00000363858#ENSG00000095794#ENST00000374726#bZIP#pKID$#ENSP00000420681#ENSG00000095794#ENST00000473940#bZIP#$#ENSP00000417807#ENSG00000095794#ENST00000487763#bZIP#$#ENSP00000344365#ENSG00000095794#ENST00000344351#bZIP#$#ENSP00000349387#ENSG00000095794#ENST00000356917#bZIP#$#ENSP00000420437#ENSG00000095794#ENST00000460270#bZIP#$#ENSP00000418336#ENSG00000095794#ENST00000463314#bZIP#$#ENSP00000419018#ENSG00000095794#ENST00000474362#bZIP#$#ENSP00000417562#ENSG00000095794#ENST00000474931#bZIP#$#ENSP00000417460#ENSG00000095794#ENST00000488328#bZIP#$#ENSP00000419075#ENSG00000095794#ENST00000488741#bZIP#$#ENSP00000417327#ENSG00000095794#ENST00000490511#bZIP#$#ENSP00000403938#ENSG00000095794#ENST00000427847#bZIP#pKID$#ENSP00000419810#ENSG00000095794#ENST00000468236#bZIP#$#ENSP00000473519#ENSG00000095794#ENST00000469949#bZIP#$#ENSP00000419924#ENSG00000095794#ENST00000489321#bZIP#pKID$#ENSP00000417399#ENSG00000095794#ENST00000494479#bZIP#	FALSE
194	ENSG00000105516	DBP	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	1628	D-box binding PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:2697]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2331750	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000105516#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20093779	$#ENSP00000222122#ENSG00000105516#ENST00000222122#bZIP#$#ENSP00000469291#ENSG00000105516#ENST00000601104#bZIP#$#ENSP00000471220#ENSG00000105516#ENST00000593500#bZIP#$#ENSP00000469426#ENSG00000105516#ENST00000599385#bZIP#	FALSE
195	ENSG00000175197	DDIT3	bZIP	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization (PMID: 12805554).	IPR004827;IPR016670	1649	DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726]	None	DBD and Full	Yes	Obligate_Multimer	pmid:12805554 has strong preference for forming heterodimers with BATF, DBP, HLF, CEBP[ABCD] over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8657121	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000175197#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22065586$#ENSG00000175197#GO:0003700#sequence-specific DNA binding transcription factor activity#IC - PMID:15322075 | IGI - PMID:24939851$#ENSG00000175197#GO:0032792#negative regulation of CREB transcription factor activity#IDA - PMID:8622660 | IGI - PMID:11478948$#ENSG00000175197#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16434966	$#ENSP00000340671#ENSG00000175197#ENST00000346473#bZIP#$#ENSP00000448665#ENSG00000175197#ENST00000551116#bZIP#$#ENSP00000447803#ENSG00000175197#ENST00000552740#bZIP#$#ENSP00000447188#ENSG00000175197#ENST00000547303#bZIP#$#ENSP00000447503#ENSG00000175197#ENST00000547526#bZIP#	FALSE
196	ENSG00000170345	FOS	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000837;IPR004827	2353	Fos proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3796]	1A02	DBD and Full	Yes	None	Structure has NFATC2, FOS and JUN bound to a site that has good match to NFATC but a bad one to a CRE-type bZIP site proteins are doing a massive protein-protein interaction interface;Prefers heterodimers with JUN, JUND and JUNB over homodimer, PMID:	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798512;11925568;15073183;2243767	Yes	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000170345#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000170345#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000170345#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9732876$#ENSG00000170345#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000306245#ENSG00000170345#ENST00000303562#bZIP#$#ENSP00000442268#ENSG00000170345#ENST00000535987#bZIP#$#ENSP00000450519#ENSG00000170345#ENST00000554617#bZIP#$#ENSP00000452386#ENSG00000170345#ENST00000555242#bZIP#$#ENSP00000450886#ENSG00000170345#ENST00000555347#bZIP#$#ENSP00000452440#ENSG00000170345#ENST00000555672#bZIP#DUF3450, IFT20$#ENSP00000452590#ENSG00000170345#ENST00000555686#bZIP#	FALSE
197	ENSG00000125740	FOSB	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000837;IPR004827	2354	FosB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3797]	None	DBD and Full	Yes	None	Prefers heterodimers with JUN, JUND and JUNB over homodimer, PMID:12805554	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:2498083;14515349;16699069	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000125740#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000125740#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000245919#ENSG00000125740#ENST00000353609#bZIP#$#ENSP00000407207#ENSG00000125740#ENST00000417353#bZIP#$#ENSP00000414177#ENSG00000125740#ENST00000443841#bZIP#DUF3450$#ENSP00000467497#ENSG00000125740#ENST00000585836#bZIP#$#ENSP00000468207#ENSG00000125740#ENST00000586615#bZIP#$#ENSP00000465068#ENSG00000125740#ENST00000590335#bZIP#$#ENSP00000466530#ENSG00000125740#ENST00000591858#bZIP#$#ENSP00000485018#ENSG00000125740#ENST00000615753#bZIP#$#ENSP00000468482#ENSG00000125740#ENST00000592811#bZIP#	FALSE
198	ENSG00000175592	FOSL1	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000837;IPR004827	8061	FOS like 1, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718]	None	DBD and Full	Yes	None	Prefers heterodimers with JUN, JUND and JUNB over homodimer, PMID:12805554	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:7504176;7791782;15608675	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000175592#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000175592#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000175592#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10918580$#ENSG00000175592#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000310170#ENSG00000175592#ENST00000312562#bZIP#$#ENSP00000393302#ENSG00000175592#ENST00000448083#bZIP#DUF3450$#ENSP00000436276#ENSG00000175592#ENST00000531493#bZIP#SPAM$#ENSP00000431594#ENSG00000175592#ENST00000532401#bZIP#$#ENSP00000434350#ENSG00000175592#ENST00000534222#bZIP#	FALSE
199	ENSG00000075426	FOSL2	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also forms heterodimers.	IPR000837;IPR004827	2355	FOS like 2, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3798]	None	DBD and Full	Yes	None	pmid:12805554 has strong preference for forming heterodimers with JUN, JUNB, JUND, CREB5 and ATF7 over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:13679379;15558021	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	No	$#ENSG00000075426#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000075426#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8954781	$#ENSP00000264716#ENSG00000075426#ENST00000264716#bZIP#$#ENSP00000368939#ENSG00000075426#ENST00000379619#bZIP#$#ENSP00000396497#ENSG00000075426#ENST00000436647#bZIP#	FALSE
200	ENSG00000144366	GULP1	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding	IPR006020;	51454	GULP, engulfment adaptor PTB domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18649]	None	not tested	not tested	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000352047#ENSG00000144366#ENST00000359135#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000386732#ENSG00000144366#ENST00000409830#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000387013#ENSG00000144366#ENST00000410051#bZIP#PID, PID_2, PTB$#ENSP00000407131#ENSG00000144366#ENST00000451191#bZIP#$#ENSP00000386289#ENSG00000144366#ENST00000409580#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000386867#ENSG00000144366#ENST00000409609#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, Pox_A_typ$#ENSP00000386402#ENSG00000144366#ENST00000409637#bZIP#PID, PID_2, PTB$#ENSP00000387171#ENSG00000144366#ENST00000409805#bZIP#Ax_dynein_light, DivIC, IncA, Pox_A_type_inc, bZIP$#ENSP00000387144#ENSG00000144366#ENST00000409843#bZIP#Ax_dynein_light, DivIC, PID, PID_2, PTB, bZIP_2$#ENSP00000391712#ENSG00000144366#ENST00000433052#bZIP#$#ENSP00000386809#ENSG00000144366#ENST00000409927#bZIP#PID	FALSE
201	ENSG00000108924	HLF	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	3131	HLF, PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:4977]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8065331	Yes	1a1, Direct HQ evidence	Sam Lambert	Tim Hughes	Yes	$#ENSG00000108924#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000226067#ENSG00000108924#ENST00000226067#bZIP#$#ENSP00000402496#ENSG00000108924#ENST00000430986#bZIP#$#ENSP00000460572#ENSG00000108924#ENST00000575345#bZIP#$#ENSP00000461455#ENSG00000108924#ENST00000572002#bZIP#	FALSE
202	ENSG00000095066	HOOK2	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding	IPR008636	29911	hook microtubule-tethering protein 2 [Source:HGNC Symbol;Acc:HGNC:19885]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	None	$#ENSP00000264827#ENSG00000095066#ENST00000264827#bZIP#HALZ, HOOK$#ENSP00000380785#ENSG00000095066#ENST00000397668#bZIP#HALZ, HOOK$#ENSP00000465042#ENSG00000095066#ENST00000587178#bZIP#HOOK$#ENSP00000466616#ENSG00000095066#ENST00000590839#bZIP#HOOK	FALSE
203	ENSG00000140575	IQGAP1	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	bZIP domain in the protein is  just a fragment.	IPR000048;IPR000593;IPR001202;IPR001715;IPR001936;IPR008936;IPR023152;IPR027417	8826	IQ motif containing GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:6110]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000268182#ENSG00000140575#ENST00000268182#bZIP#CH, IQ, RasGAP, RasGAP_C, WW$#ENSP00000480393#ENSG00000140575#ENST00000560373#bZIP#IQ, WW$#ENSP00000484647#ENSG00000140575#ENST00000559809#bZIP#	FALSE
204	ENSG00000140044	JDP2	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000837;IPR004827	122953	Jun dimerization protein 2 [Source:HGNC Symbol;Acc:HGNC:17546]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12052888	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000140044#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000140044#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000267569#ENSG00000140044#ENST00000267569#bZIP#$#ENSP00000399587#ENSG00000140044#ENST00000435893#bZIP#$#ENSP00000415558#ENSG00000140044#ENST00000419727#bZIP#$#ENSP00000409787#ENSG00000140044#ENST00000437176#bZIP#$#ENSP00000452769#ENSG00000140044#ENST00000559060#bZIP#	FALSE
205	ENSG00000177606	JUN	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002112;IPR004827;IPR005643;IPR008917	3725	Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204]	1JNM	DBD and Full	Yes	None	The structure is a homodimer; Prefers heterodimers with FOS, FOSB, FOSL1 and FOSL2 over homodimer, PMID:12805554	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12215258;15494506	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000177606#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IC - PMID:21113145$#ENSG00000177606#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:19962668$#ENSG00000177606#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000177606#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9732876$#ENSG00000177606#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IC - PMID:19861239 | IDA - PMID:2833704$#ENSG00000177606#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000360266#ENSG00000177606#ENST00000371222#bZIP#Jun	FALSE
206	ENSG00000171223	JUNB	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Prefers forming heterodimers with FOS; FOSB; FOSL1 and FOSL2 over homodimers (PMID:12805554); but, clearly can bind DNA specifically in vitro.	IPR002112;IPR004827;IPR005643;IPR008917	3726	JunB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6205]	None	DBD and Full	Yes	None	Prefers heterodimers with FOS, FOSB, FOSL1 and FOSL2 over homodimer, PMID:12805554	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12121977	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000171223#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000171223#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000303315#ENSG00000171223#ENST00000302754#bZIP#Jun	FALSE
207	ENSG00000130522	JUND	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002112;IPR004827;IPR005643;IPR008917	3727	JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206]	None	DBD	Yes	None	Prefers heterodimers with FOS, FOSB, FOSL1 and FOSL2 over homodimer, PMID:12805554	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2504580	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000130522#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000475153#ENSG00000130522#ENST00000600972#bZIP#Jun$#ENSP00000252818#ENSG00000130522#ENST00000252818#bZIP#Jun	FALSE
208	ENSG00000163808	KIF15	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Has a bZIP like fragment that lacks the basic region required for DNA binding and a STE-domain that is classified as a potential DBD in CIS-BP. It is a kinesin operating in the microtubule system (PMID: 24419385)	IPR001752;IPR024658;IPR027417;	56992	kinesin family member 15 [Source:HGNC Symbol;Acc:HGNC:17273]	None	not tested	not tested	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	None	$#ENSP00000324020#ENSG00000163808#ENST00000326047#bZIP#HMMR_C, Kinesin, Microtub_bd$#ENSP00000389982#ENSG00000163808#ENST00000425755#bZIP#Bcr-Abl_Oligo, DMPK_coil, HMMR_C, Laminin_II$#ENSP00000425499#ENSG00000163808#ENST00000481166#bZIP#Bcr-Abl_Oligo, DMPK_coil, Kinesin, Laminin_II	FALSE
209	ENSG00000171401	KRT13	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding	IPR001664;IPR002957;IPR018039	3860	keratin 13 [Source:HGNC Symbol;Acc:HGNC:6415]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000246635#ENSG00000171401#ENST00000246635#bZIP#Filament, TPR_MLP1_2$#ENSP00000336604#ENSG00000171401#ENST00000336861#bZIP#Filament, TPR_MLP1_2$#ENSP00000468221#ENSG00000171401#ENST00000587544#bZIP#Filament, TPR_MLP1_2	FALSE
210	ENSG00000178573	MAF	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;IPR013592	4094	MAF bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:6776]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000178573#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000327048#ENSG00000178573#ENST00000326043#bZIP#Maf_N$#ENSP00000455097#ENSG00000178573#ENST00000569649#bZIP#Maf_N$#ENSP00000377019#ENSG00000178573#ENST00000393350#bZIP#Maf_N	FALSE
211	ENSG00000182759	MAFA	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;IPR013592	389692	MAF bZIP transcription factor A [Source:HGNC Symbol;Acc:HGNC:23145]	4EOT	DBD	Yes	None	Structure is a homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15665000	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000182759#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000182759#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000182759#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:12368292, PMID:17941991	$#ENSP00000328364#ENSG00000182759#ENST00000333480#bZIP#Maf_N	FALSE
212	ENSG00000204103	MAFB	bZIP	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence	IPR004826;IPR004827;IPR008917;IPR013592	9935	MAF bZIP transcription factor B [Source:HGNC Symbol;Acc:HGNC:6408]	2WTY	DBD and Full	Yes	None	Structure is a homodimer	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:17158225;9571165	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000204103#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000204103#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000362410#ENSG00000204103#ENST00000373313#bZIP#Maf_N	FALSE
213	ENSG00000185022	MAFF	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;	23764	MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8107826;12490281	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000185022#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000345393#ENSG00000185022#ENST00000338483#bZIP#$#ENSP00000384094#ENSG00000185022#ENST00000407965#bZIP#$#ENSP00000391589#ENSG00000185022#ENST00000441709#bZIP#$#ENSP00000441482#ENSG00000185022#ENST00000538999#bZIP#	FALSE
214	ENSG00000197063	MAFG	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;	4097	MAF bZIP transcription factor G [Source:HGNC Symbol;Acc:HGNC:6781]	3A5T	DBD and Full	Yes	None	Structure is a homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:9421508;15574414	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000197063#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000197063#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9286713	$#ENSP00000350369#ENSG00000197063#ENST00000357736#bZIP#$#ENSP00000376173#ENSG00000197063#ENST00000392366#bZIP#$#ENSP00000459634#ENSG00000197063#ENST00000574686#bZIP#	FALSE
215	ENSG00000198517	MAFK	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;	7975	MAF bZIP transcription factor K [Source:HGNC Symbol;Acc:HGNC:6782]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; Transactivation_PMIDS:11013233;14960151	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000198517#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000198517#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9150357	$#ENSP00000344903#ENSG00000198517#ENST00000343242#bZIP#$#ENSP00000385437#ENSG00000198517#ENST00000406174#bZIP#	FALSE
216	ENSG00000159256	MORC3	bZIP	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Lacks a canonical bZIP DBD but: regulates TP53 activity (PMID: 17332504]), binds RNA in vitro (PMID: 11927593), and may be required for influenza A transcription during viral infection (PMID: 26202233).	IPR003594;IPR011124	23515	MORC family CW-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:23572]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000383333#ENSG00000159256#ENST00000400485#bZIP#DUF2353, HATPase_c, HATPase_c_3, HOOK, zf-CW	FALSE
217	ENSG00000080986	NDC80	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding	IPR005550	10403	NDC80, kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	None	$#ENSP00000261597#ENSG00000080986#ENST00000261597#bZIP#ADIP, DUF1664, Ndc80_HEC$#ENSP00000458236#ENSG00000080986#ENST00000574096#bZIP#$#ENSP00000476919#ENSG00000080986#ENST00000576274#bZIP#Ndc80_HEC$#ENSP00000461227#ENSG00000080986#ENST00000575515#bZIP#	FALSE
218	ENSG00000123405	NFE2	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;	4778	nuclear factor, erythroid 2 [Source:HGNC Symbol;Acc:HGNC:7780]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8469283	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000123405#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000312436#ENSG00000123405#ENST00000312156#bZIP#$#ENSP00000397185#ENSG00000123405#ENST00000435572#bZIP#$#ENSP00000439120#ENSG00000123405#ENST00000540264#bZIP#$#ENSP00000447558#ENSG00000123405#ENST00000553070#bZIP#	FALSE
219	ENSG00000082641	NFE2L1	bZIP	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Tested on HT-SELEX and PBM.  Neither yielded a motif.  Likely an obligate heteromer (PMID: 23661758).	IPR004826;IPR004827;IPR008917;	4779	nuclear factor, erythroid 2 like 1 [Source:HGNC Symbol;Acc:HGNC:7781]	None	DBD and Full	Yes	Obligate_Multimer	pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8036168	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000082641#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000082641#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8248256	$#ENSP00000350072#ENSG00000082641#ENST00000357480#bZIP#$#ENSP00000354855#ENSG00000082641#ENST00000362042#bZIP#$#ENSP00000461960#ENSG00000082641#ENST00000585291#bZIP#$#ENSP00000445811#ENSG00000082641#ENST00000536222#bZIP#$#ENSP00000464446#ENSG00000082641#ENST00000582155#bZIP#$#ENSP00000462003#ENSG00000082641#ENST00000579889#bZIP#$#ENSP00000461971#ENSG00000082641#ENST00000581319#bZIP#	FALSE
220	ENSG00000116044	NFE2L2	bZIP	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Has been tested by both PBM and HT-SELEX.  Neither yielded a motif.  Likely obligate heteromer.	IPR004826;IPR004827;IPR008917;	4780	nuclear factor, erythroid 2 like 2 [Source:HGNC Symbol;Acc:HGNC:7782]	None	DBD and Full	Yes	Obligate_Multimer	pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific__PMIDS:0;	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000116044#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000116044#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17015834	$#ENSP00000380252#ENSG00000116044#ENST00000397062#bZIP#$#ENSP00000380253#ENSG00000116044#ENST00000397063#bZIP#$#ENSP00000412191#ENSG00000116044#ENST00000421929#bZIP#$#ENSP00000410015#ENSG00000116044#ENST00000423513#bZIP#$#ENSP00000411575#ENSG00000116044#ENST00000446151#bZIP#$#ENSP00000400073#ENSG00000116044#ENST00000448782#bZIP#$#ENSP00000467401#ENSG00000116044#ENST00000464747#bZIP#$#ENSP00000391291#ENSG00000116044#ENST00000430047#bZIP#$#ENSP00000416308#ENSG00000116044#ENST00000458603#bZIP#	FALSE
221	ENSG00000050344	NFE2L3	bZIP	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Tested on HT-SELEX and PBM.  Neither yielded a motif.  Likely an obligate heteromer (PMID: 23661758). Strong preference for forming heterodimers with MAFG and MAFK over homodimers (PMID: 12805554).	IPR004826;IPR004827;IPR008917;	9603	nuclear factor, erythroid 2 like 3 [Source:HGNC Symbol;Acc:HGNC:7783]	None	DBD and Full	Yes	Obligate_Multimer	pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10037736;15385560	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000050344#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000050344#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10037736	$#ENSP00000056233#ENSG00000050344#ENST00000056233#bZIP#$#ENSP00000475463#ENSG00000050344#ENST00000607375#bZIP#	FALSE
222	ENSG00000165030	NFIL3	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;IPR010533;IPR016743;	4783	nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7565758;10074173	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000165030#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20093779$#ENSG00000165030#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7565758	$#ENSP00000297689#ENSG00000165030#ENST00000297689#bZIP#Vert_IL3-reg_TF	FALSE
223	ENSG00000148572	NRBF2	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding	IPR015056;	29982	nuclear receptor binding factor 2 [Source:HGNC Symbol;Acc:HGNC:19692]	None	not tested	not tested	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000277746#ENSG00000148572#ENST00000277746#bZIP#MIT, NRBF2_MIT$#ENSP00000397502#ENSG00000148572#ENST00000435510#bZIP#NRBF2_MIT	FALSE
224	ENSG00000129535	NRL	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004826;IPR004827;IPR008917;IPR013592	4901	neural retina leucine zipper [Source:HGNC Symbol;Acc:HGNC:8002]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8552602;8939891;12566383;15001570;17335001;8552602;8552602;10887186;15001570	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000129535#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8552602	$#ENSP00000380191#ENSG00000129535#ENST00000396995#bZIP#$#ENSP00000380193#ENSG00000129535#ENST00000396997#bZIP#Maf_N$#ENSP00000380197#ENSG00000129535#ENST00000397002#bZIP#Maf_N$#ENSP00000452966#ENSG00000129535#ENST00000560550#bZIP#$#ENSP00000454062#ENSG00000129535#ENST00000561028#bZIP#Maf_N	FALSE
225	ENSG00000162869	PPP1R21	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein lacks the basic region these proteins use to contact the DNA	IPR019343;IPR019348	129285	protein phosphatase 1 regulatory subunit 21 [Source:HGNC Symbol;Acc:HGNC:30595]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000281394#ENSG00000162869#ENST00000281394#bZIP#KLRAQ, TTKRSYEDQ$#ENSP00000294952#ENSG00000162869#ENST00000294952#bZIP#KLRAQ, TTKRSYEDQ$#ENSP00000415696#ENSG00000162869#ENST00000449090#bZIP#KLRAQ, TTKRSYEDQ$#ENSP00000410955#ENSG00000162869#ENST00000421486#bZIP#	FALSE
226	ENSG00000131242	RAB11FIP4	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely false-positive - appears to function primarily in the cytoplasm (PMID: 12470645).	IPR002048;IPR019018	100616248	RAB11 family interacting protein 4 [Source:HGNC Symbol;Acc:HGNC:30267]	None	not tested	Yes	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000482620#ENSG00000131242#ENST00000621161#bZIP#EF-hand_8, RBD-FIP, Shugoshin_N$#ENSP00000378227#ENSG00000131242#ENST00000394744#bZIP#RBD-FIP, Shugoshin_N$#ENSP00000463206#ENSG00000131242#ENST00000582009#bZIP#EF-hand_8$#ENSP00000465929#ENSG00000131242#ENST00000583755#bZIP#	FALSE
227	ENSG00000152193	RNF219	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part.	IPR001841;	79596	ring finger protein 219 [Source:HGNC Symbol;Acc:HGNC:20308]	None	not tested	Yes	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000282003#ENSG00000152193#ENST00000282003#bZIP#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-P11, zf-RING_	FALSE
228	ENSG00000153130	SCOC	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part.	IPR019357;	60592	short coiled-coil protein [Source:HGNC Symbol;Acc:HGNC:20335]	None	not tested	not tested	None	Not a proper bZIP, contains only a small leusine zipper region but lacks the DNA-interfacing basic part	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000377751#ENSG00000153130#ENST00000394201#bZIP#$#ENSP00000426649#ENSG00000153130#ENST00000506597#bZIP#$#ENSP00000477352#ENSG00000153130#ENST00000608372#bZIP#DUF2205, HALZ, IncA$#ENSP00000477812#ENSG00000153130#ENST00000614192#bZIP#DUF2205, HALZ, IncA$#ENSP00000377753#ENSG00000153130#ENST00000394203#bZIP#$#ENSP00000377755#ENSG00000153130#ENST00000394205#bZIP#$#ENSP00000421355#ENSG00000153130#ENST00000502535#bZIP#$#ENSP00000424605#ENSG00000153130#ENST00000512749#bZIP#	FALSE
229	ENSG00000167074	TEF	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	7008	TEF, PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:11722]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8396764;8440239;14702338	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000167074#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000266304#ENSG00000167074#ENST00000266304#bZIP#$#ENSP00000385256#ENSG00000167074#ENST00000406644#bZIP#$#ENSP00000411170#ENSG00000167074#ENST00000413942#bZIP#	FALSE
230	ENSG00000115993	TRAK2	bZIP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The bZIP domain is only a partial 40AA sequence that will not bind DNA.	IPR006933;IPR022154	66008	trafficking kinesin protein 2 [Source:HGNC Symbol;Acc:HGNC:13206]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	None	$#ENSP00000328875#ENSG00000115993#ENST00000332624#bZIP#HAP1_N, Milton$#ENSP00000409333#ENSG00000115993#ENST00000430254#bZIP#ERM, HAP1_N$#ENSP00000388254#ENSG00000115993#ENST00000440597#bZIP#	FALSE
231	ENSG00000100219	XBP1	bZIP	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004827;	7494	X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2321018	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000100219#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019$#ENSG00000100219#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:1903538, PMID:8657566	$#ENSP00000216037#ENSG00000100219#ENST00000216037#bZIP#$#ENSP00000384295#ENSG00000100219#ENST00000405219#bZIP#$#ENSP00000385162#ENSG00000100219#ENST00000403532#bZIP#	FALSE
232	ENSG00000267179	AC008770.3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880	None	CTD-2006C1.13	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000467286#ENSG00000267179#ENST00000590798#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000465172#ENSG00000267179#ENST00000591944#C2H2 ZF Containing Proteins#KRAB	FALSE
233	ENSG00000233757	AC092835.1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	KRAB C2H2 Protein	None	None	AC092835.1	None	not tested	not tested	None	KRAB C2H2 Protein	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
234	ENSG00000264668	AC138696.1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR007087;IPR015880	None	RP13-582O9.6	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000428966#ENSG00000264668#ENST00000522452#C2H2 ZF Containing Proteins#	FALSE
235	ENSG00000139154	AEBP2	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	121536	AE binding protein 2 [Source:HGNC Symbol;Acc:HGNC:24051]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000139154#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000266508#ENSG00000139154#ENST00000266508#C2H2 ZF Containing Proteins#$#ENSP00000381840#ENSG00000139154#ENST00000398864#C2H2 ZF Containing Proteins#$#ENSP00000354267#ENSG00000139154#ENST00000360995#C2H2 ZF Containing Proteins#$#ENSP00000381715#ENSG00000139154#ENST00000398731#C2H2 ZF Containing Proteins#$#ENSP00000445587#ENSG00000139154#ENST00000512223#C2H2 ZF Containing Proteins#$#ENSP00000437983#ENSG00000139154#ENST00000541908#C2H2 ZF Containing Proteins#	FALSE
236	ENSG00000105127	AKAP8	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	(PMID: 26683827) uses SELEX to show binding to G/C rich DNA, and confirms association with rDNA promoters.  Also claims it has a C2H2 domain.  Interpro says it has a C2H2 AKAP95-type 1 and a C2H2 AKAP95-type 2 domain.  SMART does identify a single C2H2 domain.	IPR007071;	10270	A-kinase anchoring protein 8 [Source:HGNC Symbol;Acc:HGNC:378]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000269701#ENSG00000105127#ENST00000269701#Other#AKAP95, zf-C2H2_2	FALSE
237	ENSG00000011243	AKAP8L	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	This is homologous to the AKAP8/AKAP95 protein. which has been shown by SELEX to bind GC rich sequences (PMID: 26683827).	IPR007071;	26993	A-kinase anchoring protein 8 like [Source:HGNC Symbol;Acc:HGNC:29857]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$#ENSP00000380557#ENSG00000011243#ENST00000397410#Other#AKAP95$#ENSP00000470952#ENSG00000011243#ENST00000595465#Other#AKAP95	FALSE
238	ENSG00000163516	ANKZF1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR002110;IPR007087;IPR020683;	55139	ankyrin repeat and zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25527]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	None	$#ENSP00000321617#ENSG00000163516#ENST00000323348#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000386815#ENSG00000163516#ENST00000409849#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000386337#ENSG00000163516#ENST00000410034#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000394652#ENSG00000163516#ENST00000436226#Other#$#ENSP00000394359#ENSG00000163516#ENST00000453432#Other#	FALSE
239	ENSG00000166454	ATMIN	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	23300	ATM interactor [Source:HGNC Symbol;Acc:HGNC:29034]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000299575#ENSG00000166454#ENST00000299575#C2H2 ZF Containing Proteins#$#ENSP00000463478#ENSG00000166454#ENST00000564241#C2H2 ZF Containing Proteins#$#ENSP00000455497#ENSG00000166454#ENST00000566488#C2H2 ZF Containing Proteins#$#ENSP00000464427#ENSG00000166454#ENST00000565237#C2H2 ZF Containing Proteins#	FALSE
240	ENSG00000119866	BCL11A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	53335	B-cell CLL/lymphoma 11A [Source:HGNC Symbol;Acc:HGNC:13221]	None	Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Tim Hughes	Yes	$#ENSG00000119866#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19153051	$#ENSP00000338774#ENSG00000119866#ENST00000335712#C2H2 ZF Containing Proteins#$#ENSP00000349300#ENSG00000119866#ENST00000356842#C2H2 ZF Containing Proteins#$#ENSP00000351307#ENSG00000119866#ENST00000358510#C2H2 ZF Containing Proteins#$#ENSP00000352648#ENSG00000119866#ENST00000359629#C2H2 ZF Containing Proteins#$#ENSP00000487844#ENSG00000119866#ENST00000409351#C2H2 ZF Containing Proteins#	FALSE
241	ENSG00000127152	BCL11B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	64919	B-cell CLL/lymphoma 11B [Source:HGNC Symbol;Acc:HGNC:13222]	None	DBD	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000127152#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000280435#ENSG00000127152#ENST00000345514#C2H2 ZF Containing Proteins#$#ENSP00000349723#ENSG00000127152#ENST00000357195#C2H2 ZF Containing Proteins#$#ENSP00000387419#ENSG00000127152#ENST00000443726#C2H2 ZF Containing Proteins#	FALSE
242	ENSG00000113916	BCL6	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	604	B-cell CLL/lymphoma 6 [Source:HGNC Symbol;Acc:HGNC:1001]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12097386;15659391	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000113916#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000113916#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:15577913	$#ENSP00000232014#ENSG00000113916#ENST00000232014#C2H2 ZF Containing Proteins#BTB, DZR$#ENSP00000384371#ENSG00000113916#ENST00000406870#C2H2 ZF Containing Proteins#BTB, DZR$#ENSP00000413122#ENSG00000113916#ENST00000450123#C2H2 ZF Containing Proteins#BTB, DZR$#ENSP00000415574#ENSG00000113916#ENST00000430339#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000414455#ENSG00000113916#ENST00000438077#C2H2 ZF Containing Proteins#BTB	FALSE
243	ENSG00000161940	BCL6B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	255877	B-cell CLL/lymphoma 6B [Source:HGNC Symbol;Acc:HGNC:1002]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000161940#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000293805#ENSG00000161940#ENST00000293805#C2H2 ZF Containing Proteins#BTB$#ENSP00000460282#ENSG00000161940#ENST00000573503#C2H2 ZF Containing Proteins#BTB$#ENSP00000445010#ENSG00000161940#ENST00000537931#C2H2 ZF Containing Proteins#$#ENSP00000460071#ENSG00000161940#ENST00000576705#C2H2 ZF Containing Proteins#BTB	FALSE
244	ENSG00000169594	BNC1	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	646	basonuclin 1 [Source:HGNC Symbol;Acc:HGNC:1081]	None	not tested	not tested	None	None	a	Yes	No	Yes	2a2, orthologous lower confidence evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000169594#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9099851	$#ENSP00000307041#ENSG00000169594#ENST00000345382#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000456727#ENSG00000169594#ENST00000569704#C2H2 ZF Containing Proteins#zf-C2H2_aberr	FALSE
245	ENSG00000173068	BNC2	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	Has a putative AT-hook	None	IPR007087;IPR007527;IPR015880;	54796	basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988]	None	DBD	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000392212#ENSG00000173068#ENST00000411752#C2H2 ZF Containing Proteins#$#ENSP00000444640#ENSG00000173068#ENST00000545497#C2H2 ZF Containing Proteins#$#ENSP00000474045#ENSG00000173068#ENST00000603713#C2H2 ZF Containing Proteins#$#ENSP00000477717#ENSG00000173068#ENST00000613349#C2H2 ZF Containing Proteins#$#ENSP00000482793#ENSG00000173068#ENST00000617779#C2H2 ZF Containing Proteins#$#ENSP00000370047#ENSG00000173068#ENST00000380672#C2H2 ZF Containing Proteins#$#ENSP00000474647#ENSG00000173068#ENST00000486514#C2H2 ZF Containing Proteins#$#ENSP00000474468#ENSG00000173068#ENST00000468187#C2H2 ZF Containing Proteins#$#ENSP00000474832#ENSG00000173068#ENST00000471301#C2H2 ZF Containing Proteins#	FALSE
246	ENSG00000130940	CASZ1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	54897	castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002]	None	not tested	Yes	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000366221#ENSG00000130940#ENST00000377022#C2H2 ZF Containing Proteins#RNA_pol_3_Rpc31$#ENSP00000339445#ENSG00000130940#ENST00000344008#C2H2 ZF Containing Proteins#$#ENSP00000467769#ENSG00000130940#ENST00000447850#C2H2 ZF Containing Proteins#	FALSE
247	ENSG00000159588	CCDC17	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	None	149483	coiled-coil domain containing 17 [Source:HGNC Symbol;Acc:HGNC:26574]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000411335#ENSG00000159588#ENST00000445048#C2H2 ZF Containing Proteins#$#ENSP00000389415#ENSG00000159588#ENST00000421127#C2H2 ZF Containing Proteins#$#ENSP00000432172#ENSG00000159588#ENST00000528266#C2H2 ZF Containing Proteins#	FALSE
248	ENSG00000198824	CHAMP1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;IPR015880	283489	chromosome alignment maintaining phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:20311]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000354730#ENSG00000198824#ENST00000361283#C2H2 ZF Containing Proteins#$#ENSP00000474448#ENSG00000198824#ENST00000463003#C2H2 ZF Containing Proteins#zf-H2C2_5	FALSE
249	ENSG00000147183	CPXCR1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;	53336	CPX chromosome region, candidate 1 [Source:HGNC Symbol;Acc:HGNC:2332]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000276127#ENSG00000147183#ENST00000276127#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000484986#ENSG00000147183#ENST00000614120#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000362203#ENSG00000147183#ENST00000373111#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz	FALSE
250	ENSG00000102974	CTCF	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR007087;IPR015880	10664	CCCTC-binding factor [Source:HGNC Symbol;Acc:HGNC:13723]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8246978;15143173	Yes	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	$#ENSG00000102974#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8649389$#ENSG00000102974#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000102974#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8649389, PMID:9591631	$#ENSP00000264010#ENSG00000102974#ENST00000264010#C2H2 ZF Containing Proteins#$#ENSP00000384707#ENSG00000102974#ENST00000401394#C2H2 ZF Containing Proteins#	FALSE
251	ENSG00000124092	CTCFL	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	140690	CCCTC-binding factor like [Source:HGNC Symbol;Acc:HGNC:16234]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000124092#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16140944	$#ENSP00000243914#ENSG00000124092#ENST00000243914#C2H2 ZF Containing Proteins#$#ENSP00000360239#ENSG00000124092#ENST00000371196#C2H2 ZF Containing Proteins#$#ENSP00000399061#ENSG00000124092#ENST00000422869#C2H2 ZF Containing Proteins#$#ENSP00000415579#ENSG00000124092#ENST00000423479#C2H2 ZF Containing Proteins#$#ENSP00000415329#ENSG00000124092#ENST00000429804#C2H2 ZF Containing Proteins#$#ENSP00000409344#ENSG00000124092#ENST00000432255#C2H2 ZF Containing Proteins#$#ENSP00000392034#ENSG00000124092#ENST00000433949#C2H2 ZF Containing Proteins#$#ENSP00000476577#ENSG00000124092#ENST00000481655#C2H2 ZF Containing Proteins#$#ENSP00000437999#ENSG00000124092#ENST00000502686#C2H2 ZF Containing Proteins#$#ENSP00000439998#ENSG00000124092#ENST00000539382#C2H2 ZF Containing Proteins#$#ENSP00000477165#ENSG00000124092#ENST00000608158#C2H2 ZF Containing Proteins#$#ENSP00000476783#ENSG00000124092#ENST00000608263#C2H2 ZF Containing Proteins#$#ENSP00000476458#ENSG00000124092#ENST00000608425#C2H2 ZF Containing Proteins#$#ENSP00000477488#ENSG00000124092#ENST00000608440#C2H2 ZF Containing Proteins#$#ENSP00000476718#ENSG00000124092#ENST00000608903#C2H2 ZF Containing Proteins#$#ENSP00000476398#ENSG00000124092#ENST00000609232#C2H2 ZF Containing Proteins#	FALSE
252	ENSG00000011332	DPF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	This protein contains C2H2 ZFs missed by Pfam scanning.	IPR001965;IPR007087;IPR011011;IPR015880;IPR019787;IPR025750	8193	double PHD fingers 1 [Source:HGNC Symbol;Acc:HGNC:20225]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000347716#ENSG00000011332#ENST00000355526#Other#PHD, Requiem_N$#ENSP00000412098#ENSG00000011332#ENST00000412732#Other#PHD, Requiem_N$#ENSP00000397354#ENSG00000011332#ENST00000420980#Other#PHD, Requiem_N$#ENSP00000483226#ENSG00000011332#ENST00000614244#Other#PHD, Requiem_N$#ENSP00000391884#ENSG00000011332#ENST00000414789#Other#PHD, Requiem_N	FALSE
253	ENSG00000205683	DPF3	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	Single C2H2 domain	Single C2H2 ZF. PHD domains mediate recognition of acetylated histones (PMID: 20613843); unclear if the ZF contributes DNA-binding specificity to the interaction.	IPR001965;IPR007087;IPR011011;IPR015880;IPR019787;IPR025750	8110	double PHD fingers 3 [Source:HGNC Symbol;Acc:HGNC:17427]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000441640#ENSG00000205683#ENST00000541685#C2H2 ZF Containing Proteins#Lar_restr_allev, PHD, Requiem_N$#ENSP00000450518#ENSG00000205683#ENST00000556509#C2H2 ZF Containing Proteins#PHD, PHD_4, Requiem_N$#ENSP00000444662#ENSG00000205683#ENST00000546183#C2H2 ZF Containing Proteins#Lar_restr_allev, PHD, Requiem_N$#ENSP00000479526#ENSG00000205683#ENST00000610283#C2H2 ZF Containing Proteins#Lar_restr_allev, PHD, Requiem_N	FALSE
254	ENSG00000134874	DZIP1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain; Has a putative AT-hook	None	IPR007087;IPR015880	22873	DAZ interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:20908]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000355018#ENSG00000134874#ENST00000361156#C2H2 ZF Containing Proteins#Dzip-like_N$#ENSP00000355175#ENSG00000134874#ENST00000361396#C2H2 ZF Containing Proteins#Dzip-like_N$#ENSP00000366025#ENSG00000134874#ENST00000376829#C2H2 ZF Containing Proteins#Dzip-like_N$#ENSP00000257312#ENSG00000134874#ENST00000347108#C2H2 ZF Containing Proteins#Dzip-like_N	FALSE
255	ENSG00000167967	E4F1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	1877	E4F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3121]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__DNA Binding_PMIDS:2169022	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000167967#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000167967#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10869426, PMID:9121437	$#ENSP00000301727#ENSG00000167967#ENST00000301727#C2H2 ZF Containing Proteins#$#ENSP00000457672#ENSG00000167967#ENST00000564139#C2H2 ZF Containing Proteins#$#ENSP00000456760#ENSG00000167967#ENST00000565090#C2H2 ZF Containing Proteins#$#ENSP00000454652#ENSG00000167967#ENST00000565413#C2H2 ZF Containing Proteins#	FALSE
256	ENSG00000102189	EEA1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Based on (PMID: 20534488), the protein has a C2H2 ZF domain; but it uses the domain for contacting RAB5A rather than for binding DNA.	IPR000306;IPR007087;IPR011011;IPR017455	8411	early endosome antigen 1 [Source:HGNC Symbol;Acc:HGNC:3185]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000317955#ENSG00000102189#ENST00000322349#Other#Atg14, FYVE$#ENSP00000446785#ENSG00000102189#ENST00000549790#Other#	FALSE
257	ENSG00000120738	EGR1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880;IPR021839;IPR021849	1958	early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238]	1A1F	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8336701;9858508;10049687	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000120738#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000120738#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12560508	$#ENSP00000239938#ENSG00000120738#ENST00000239938#C2H2 ZF Containing Proteins#Cornifin, DUF3432, DUF3446	FALSE
258	ENSG00000122877	EGR2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Binds HOX4A promoter (PMID:21836637)	IPR007087;IPR015880;IPR021849;	1959	early growth response 2 [Source:HGNC Symbol;Acc:HGNC:3239]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12687019	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000122877#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12687019$#ENSG00000122877#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14532282	$#ENSP00000242480#ENSG00000122877#ENST00000242480#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000402040#ENSG00000122877#ENST00000439032#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000387634#ENSG00000122877#ENST00000411732#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000490154#ENSG00000122877#ENST00000637191#C2H2 ZF Containing Proteins#DUF3446	FALSE
259	ENSG00000179388	EGR3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880;IPR021849;	1960	early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:1906159	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000179388#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1906159, PMID:9731539	$#ENSP00000318057#ENSG00000179388#ENST00000317216#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000430310#ENSG00000179388#ENST00000522910#C2H2 ZF Containing Proteins#DUF3446$#ENSP00000429370#ENSG00000179388#ENST00000519492#C2H2 ZF Containing Proteins#	FALSE
260	ENSG00000135625	EGR4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	1961	early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241]	None	DBD	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17192429	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000135625#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1584812	$#ENSP00000419687#ENSG00000135625#ENST00000436467#C2H2 ZF Containing Proteins#$#ENSP00000445626#ENSG00000135625#ENST00000545030#C2H2 ZF Containing Proteins#	FALSE
261	ENSG00000164334	FAM170A	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Degenerate C2H2-ZFP. Localizes to the nucleus and overexpression upregulates other genes (PMID: 20162441).	None	340069	family with sequence similarity 170 member A [Source:HGNC Symbol;Acc:HGNC:27963]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000423697#ENSG00000164334#ENST00000509264#Other#$#ENSP00000422684#ENSG00000164334#ENST00000515256#Other#$#ENSP00000482552#ENSG00000164334#ENST00000613773#Other#$#ENSP00000483075#ENSG00000164334#ENST00000620555#Other#	FALSE
262	ENSG00000128610	FEZF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	389549	FEZ family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:22788]	None	Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000128610#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000392727#ENSG00000128610#ENST00000427185#C2H2 ZF Containing Proteins#$#ENSP00000411145#ENSG00000128610#ENST00000442488#C2H2 ZF Containing Proteins#$#ENSP00000406919#ENSG00000128610#ENST00000418046#C2H2 ZF Containing Proteins#	FALSE
263	ENSG00000153266	FEZF2	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	55079	FEZ family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13506]	None	not tested	Yes	None	None	c	Yes	TF Gene Candidate__DNA Binding_PMIDS:12469125	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000153266#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000153266#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000283268#ENSG00000153266#ENST00000283268#C2H2 ZF Containing Proteins#$#ENSP00000418804#ENSG00000153266#ENST00000475839#C2H2 ZF Containing Proteins#$#ENSP00000418589#ENSG00000153266#ENST00000486811#C2H2 ZF Containing Proteins#	FALSE
264	ENSG00000179943	FIZ1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Protein has a decent cassette of C2H2 ZF domains (not all are detected by Pfam). It has been also shown to interact with homeodomain protein CRX (PMID: 18854042) and MAF-subtype bZIP protein NRL (PMID: 12566383).	IPR007087;IPR015880	84922	FLT3 interacting zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25917]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000221665#ENSG00000179943#ENST00000221665#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000465131#ENSG00000179943#ENST00000590714#C2H2 ZF Containing Proteins#$#ENSP00000468342#ENSG00000179943#ENST00000587678#C2H2 ZF Containing Proteins#$#ENSP00000468018#ENSG00000179943#ENST00000587414#C2H2 ZF Containing Proteins#	FALSE
265	ENSG00000162676	GFI1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	2672	growth factor independent 1 transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4237]	2KMK	DBD	not tested	None	3 znf NMR structure	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8754800	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000162676#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19506020$#ENSG00000162676#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000359357#ENSG00000162676#ENST00000370332#C2H2 ZF Containing Proteins#$#ENSP00000399719#ENSG00000162676#ENST00000427103#C2H2 ZF Containing Proteins#$#ENSP00000294702#ENSG00000162676#ENST00000294702#C2H2 ZF Containing Proteins#	FALSE
266	ENSG00000165702	GFI1B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	8328	growth factor independent 1B transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4238]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000344782#ENSG00000165702#ENST00000339463#C2H2 ZF Containing Proteins#$#ENSP00000361195#ENSG00000165702#ENST00000372122#C2H2 ZF Containing Proteins#$#ENSP00000490303#ENSG00000165702#ENST00000636137#C2H2 ZF Containing Proteins#$#ENSP00000489646#ENSG00000165702#ENST00000636263#C2H2 ZF Containing Proteins#	FALSE
267	ENSG00000111087	GLI1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	2735	GLI family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:4317]	2GLI	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10559945;11719506;15087129	No	1a1, Direct HQ evidence	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000111087#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000228682#ENSG00000111087#ENST00000228682#C2H2 ZF Containing Proteins#$#ENSP00000434408#ENSG00000111087#ENST00000528467#C2H2 ZF Containing Proteins#$#ENSP00000434421#ENSG00000111087#ENST00000528432#C2H2 ZF Containing Proteins#$#ENSP00000436671#ENSG00000111087#ENST00000532291#C2H2 ZF Containing Proteins#	FALSE
268	ENSG00000074047	GLI2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	2736	GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:2850480;3563490	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000074047#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000074047#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15994174	$#ENSP00000441454#ENSG00000074047#ENST00000360874#C2H2 ZF Containing Proteins#$#ENSP00000354586#ENSG00000074047#ENST00000361492#C2H2 ZF Containing Proteins#$#ENSP00000398992#ENSG00000074047#ENST00000418323#C2H2 ZF Containing Proteins#$#ENSP00000390436#ENSG00000074047#ENST00000452319#C2H2 ZF Containing Proteins#	FALSE
269	ENSG00000106571	GLI3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	2737	GLI family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:4319]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10433919;12435627;16396903	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000106571#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000106571#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10077605, PMID:17000779, PMID:17764085	$#ENSP00000407963#ENSG00000106571#ENST00000437480#C2H2 ZF Containing Proteins#$#ENSP00000406135#ENSG00000106571#ENST00000448703#C2H2 ZF Containing Proteins#$#ENSP00000379258#ENSG00000106571#ENST00000395925#C2H2 ZF Containing Proteins#	FALSE
270	ENSG00000250571	GLI4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	Protein is not closely homologous to GLI1-3 proteins.	IPR007087;IPR015880	2738	GLI family zinc finger 4 [Source:HGNC Symbol;Acc:HGNC:4320]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000250571#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000345024#ENSG00000250571#ENST00000340042#C2H2 ZF Containing Proteins#$#ENSP00000430987#ENSG00000250571#ENST00000523522#C2H2 ZF Containing Proteins#$#ENSP00000344727#ENSG00000250571#ENST00000344692#C2H2 ZF Containing Proteins#$#ENSP00000429514#ENSG00000250571#ENST00000517530#C2H2 ZF Containing Proteins#$#ENSP00000427881#ENSG00000250571#ENST00000520021#C2H2 ZF Containing Proteins#$#ENSP00000430292#ENSG00000250571#ENST00000521682#C2H2 ZF Containing Proteins#	FALSE
271	ENSG00000174332	GLIS1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	148979	GLIS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:29525]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000174332#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000174332#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000309653#ENSG00000174332#ENST00000312233#C2H2 ZF Containing Proteins#$#ENSP00000486112#ENSG00000174332#ENST00000628545#C2H2 ZF Containing Proteins#	FALSE
272	ENSG00000126603	GLIS2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	84662	GLIS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:29450]	None	DBD	Yes	None	None	b	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:11741991;16326862	No	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	$#ENSG00000126603#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000126603#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000395547#ENSG00000126603#ENST00000433375#C2H2 ZF Containing Proteins#FOXP-CC$#ENSP00000262366#ENSG00000126603#ENST00000262366#C2H2 ZF Containing Proteins#FOXP-CC	FALSE
273	ENSG00000107249	GLIS3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	169792	GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:28510]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	None	$#ENSP00000325494#ENSG00000107249#ENST00000324333#C2H2 ZF Containing Proteins#$#ENSP00000418671#ENSG00000107249#ENST00000462164#C2H2 ZF Containing Proteins#$#ENSP00000417794#ENSG00000107249#ENST00000477901#C2H2 ZF Containing Proteins#$#ENSP00000418995#ENSG00000107249#ENST00000478315#C2H2 ZF Containing Proteins#$#ENSP00000418005#ENSG00000107249#ENST00000478844#C2H2 ZF Containing Proteins#$#ENSP00000417883#ENSG00000107249#ENST00000481827#C2H2 ZF Containing Proteins#	FALSE
274	ENSG00000122034	GTF3A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	2971	General transcription factor IIIA [Source:HGNC Symbol;Acc:HGNC:4662]	1TF3	not tested	Yes	None	3 ZNF NMR structure	x	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000370532#ENSG00000122034#ENST00000381140#C2H2 ZF Containing Proteins#	FALSE
275	ENSG00000125812	GZF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	64412	GDNF inducible zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:15808]	None	not tested	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Pratyush Das	Yes	$#ENSG00000125812#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16049025 | IMP - PMID:16049025$#ENSG00000125812#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:16049025 | IMP - PMID:16049025	$#ENSP00000338290#ENSG00000125812#ENST00000338121#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-met$#ENSP00000366250#ENSG00000125812#ENST00000377051#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-met$#ENSP00000410009#ENSG00000125812#ENST00000424216#C2H2 ZF Containing Proteins#	FALSE
276	ENSG00000177374	HIC1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	3090	hypermethylated in cancer 1 [Source:HGNC Symbol;Acc:HGNC:4909]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15231840	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000177374#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15231840 | TAS - PMID:7585125	$#ENSP00000382742#ENSG00000177374#ENST00000399849#C2H2 ZF Containing Proteins#BTB$#ENSP00000476554#ENSG00000177374#ENST00000571875#C2H2 ZF Containing Proteins#BTB$#ENSP00000460268#ENSG00000177374#ENST00000571990#C2H2 ZF Containing Proteins#BTB$#ENSP00000461476#ENSG00000177374#ENST00000574370#C2H2 ZF Containing Proteins#$#ENSP00000477858#ENSG00000177374#ENST00000619757#C2H2 ZF Containing Proteins#BTB$#ENSP00000467045#ENSG00000177374#ENST00000576444#C2H2 ZF Containing Proteins#BTB	FALSE
277	ENSG00000169635	HIC2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	23119	hypermethylated in cancer 2 [Source:HGNC Symbol;Acc:HGNC:18595]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000385319#ENSG00000169635#ENST00000407464#C2H2 ZF Containing Proteins#BTB$#ENSP00000384889#ENSG00000169635#ENST00000407598#C2H2 ZF Containing Proteins#BTB$#ENSP00000387757#ENSG00000169635#ENST00000443632#C2H2 ZF Containing Proteins#BTB	FALSE
278	ENSG00000172273	HINFP	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	25988	histone H4 transcription factor [Source:HGNC Symbol;Acc:HGNC:17850]	None	DBD and Full	not tested	None	Jolma2013 HT-SELEX model has erroneous symbol HINFP1	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000172273#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000172273#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:9540062	$#ENSP00000318085#ENSG00000172273#ENST00000350777#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000436815#ENSG00000172273#ENST00000527410#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000433836#ENSG00000172273#ENST00000530678#C2H2 ZF Containing Proteins#$#ENSP00000431468#ENSG00000172273#ENST00000529988#C2H2 ZF Containing Proteins#	FALSE
279	ENSG00000095951	HIVEP1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	3096	Human immunodeficiency virus type I enhancer binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4920]	None	not tested	not tested	None	None	a	Yes	No	No	2a1, Lower confidence direct evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000095951#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IBA - GO_REF:0000033	$#ENSP00000368698#ENSG00000095951#ENST00000379388#C2H2 ZF Containing Proteins#$#ENSP00000419721#ENSG00000095951#ENST00000484210#C2H2 ZF Containing Proteins#$#ENSP00000417348#ENSG00000095951#ENST00000487103#C2H2 ZF Containing Proteins#$#ENSP00000409078#ENSG00000095951#ENST00000442081#C2H2 ZF Containing Proteins#$#ENSP00000419762#ENSG00000095951#ENST00000491710#C2H2 ZF Containing Proteins#	FALSE
280	ENSG00000010818	HIVEP2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	3097	human immunodeficiency virus type I enhancer binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4921]	None	not tested	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10207097	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000010818#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000356575#ENSG00000010818#ENST00000367603#C2H2 ZF Containing Proteins#$#ENSP00000012134#ENSG00000010818#ENST00000012134#C2H2 ZF Containing Proteins#$#ENSP00000356576#ENSG00000010818#ENST00000367604#C2H2 ZF Containing Proteins#	FALSE
281	ENSG00000127124	HIVEP3	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	Has a putative AT-hook	Binds to NFKB-like consensus sequence to repress transcription (PMID: 21189157). PWMs for HIVEP1 and 2 in Transfac and Hocomoco are also NFKB-like.	IPR007087;IPR015880	59269	human immunodeficiency virus type I enhancer binding protein 3 [Source:HGNC Symbol;Acc:HGNC:13561]	None	not tested	not tested	None	None	a	Yes	No	Yes	2a2, orthologous lower confidence evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000127124#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000361664#ENSG00000127124#ENST00000372583#C2H2 ZF Containing Proteins#$#ENSP00000361665#ENSG00000127124#ENST00000372584#C2H2 ZF Containing Proteins#	FALSE
282	ENSG00000181666	HKR1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284459	HKR1, GLI-Kruppel zinc finger family member [Source:HGNC Symbol;Acc:HGNC:4928]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000315505#ENSG00000181666#ENST00000324411#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_11, zf-C2H2_4$#ENSP00000375994#ENSG00000181666#ENST00000392153#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_11, zf-C2H2_4$#ENSP00000438261#ENSG00000181666#ENST00000541583#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4$#ENSP00000466472#ENSG00000181666#ENST00000591259#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437774#ENSG00000181666#ENST00000544914#C2H2 ZF Containing Proteins#$#ENSP00000467562#ENSG00000181666#ENST00000589392#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_11, zf-C2H2_4$#ENSP00000468572#ENSG00000181666#ENST00000590166#C2H2 ZF Containing Proteins#$#ENSP00000466856#ENSG00000181666#ENST00000591134#C2H2 ZF Containing Proteins#$#ENSP00000466467#ENSG00000181666#ENST00000591471#C2H2 ZF Containing Proteins#$#ENSP00000468528#ENSG00000181666#ENST00000589801#C2H2 ZF Containing Proteins#$#ENSP00000465884#ENSG00000181666#ENST00000592768#C2H2 ZF Containing Proteins#	TRUE
283	ENSG00000185811	IKZF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	10320	IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15841184	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000185811#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000331614#ENSG00000185811#ENST00000331340#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000352123#ENSG00000185811#ENST00000359197#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000388478#ENSG00000185811#ENST00000413698#C2H2 ZF Containing Proteins#$#ENSP00000409588#ENSG00000185811#ENST00000426121#C2H2 ZF Containing Proteins#$#ENSP00000413025#ENSG00000185811#ENST00000439701#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000483016#ENSG00000185811#ENST00000612658#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000396554#ENSG00000185811#ENST00000438033#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
284	ENSG00000030419	IKZF2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	22807	IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000030419#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000342876#ENSG00000030419#ENST00000342002#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000363439#ENSG00000030419#ENST00000374319#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000402132#ENSG00000030419#ENST00000452786#C2H2 ZF Containing Proteins#$#ENSP00000406783#ENSG00000030419#ENST00000433134#C2H2 ZF Containing Proteins#	FALSE
285	ENSG00000161405	IKZF3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	22806	IKAROS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:13178]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:9155026	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000161405#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000161405#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10552935	$#ENSP00000344544#ENSG00000161405#ENST00000346872#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000367179#ENSG00000161405#ENST00000377944#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000367180#ENSG00000161405#ENST00000377945#C2H2 ZF Containing Proteins#$#ENSP00000367188#ENSG00000161405#ENST00000377952#C2H2 ZF Containing Proteins#$#ENSP00000367194#ENSG00000161405#ENST00000377958#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000377741#ENSG00000161405#ENST00000394189#C2H2 ZF Containing Proteins#$#ENSP00000403776#ENSG00000161405#ENST00000439167#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000438972#ENSG00000161405#ENST00000535189#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000485515#ENSG00000161405#ENST00000623724#C2H2 ZF Containing Proteins#$#ENSP00000462452#ENSG00000161405#ENST00000583368#C2H2 ZF Containing Proteins#	FALSE
286	ENSG00000123411	IKZF4	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	64375	IKAROS family zinc finger 4 [Source:HGNC Symbol;Acc:HGNC:13179]	None	DBD	not tested	None	None	b	Yes	No	Yes	2a2, orthologous lower confidence evidence	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000123411#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10978333	$#ENSP00000412101#ENSG00000123411#ENST00000431367#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000450020#ENSG00000123411#ENST00000547791#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000448419#ENSG00000123411#ENST00000547167#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000449168#ENSG00000123411#ENST00000552689#C2H2 ZF Containing Proteins#	FALSE
287	ENSG00000095574	IKZF5	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	64376	IKAROS family zinc finger 5 [Source:HGNC Symbol;Acc:HGNC:14283]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000095574#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000357881#ENSG00000095574#ENST00000368886#C2H2 ZF Containing Proteins#$#ENSP00000478056#ENSG00000095574#ENST00000617859#C2H2 ZF Containing Proteins#	FALSE
288	ENSG00000173404	INSM1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	3642	INSM transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:6090]	None	DBD	not tested	None	Model looks specific	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000173404#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16569215$#ENSG00000173404#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11842116, PMID:16569215, PMID:18417529	$#ENSP00000312631#ENSG00000173404#ENST00000310227#C2H2 ZF Containing Proteins#	FALSE
289	ENSG00000168348	INSM2	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	84684	INSM transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:17539]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000306523#ENSG00000168348#ENST00000307169#C2H2 ZF Containing Proteins#	FALSE
290	ENSG00000153814	JAZF1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	221895	JAZF zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:28917]	None	DBD and Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000153814#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000283928#ENSG00000153814#ENST00000283928#C2H2 ZF Containing Proteins#$#ENSP00000388302#ENSG00000153814#ENST00000427814#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_aberr$#ENSP00000387976#ENSG00000153814#ENST00000430432#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000415096#ENSG00000153814#ENST00000447620#C2H2 ZF Containing Proteins#zf-C2H2_aberr	FALSE
291	ENSG00000136504	KAT7	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR002515;IPR002717;IPR016181;	11143	lysine acetyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:17016]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000136504#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000259021#ENSG00000136504#ENST00000259021#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000398961#ENSG00000136504#ENST00000424009#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000409477#ENSG00000136504#ENST00000435742#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000413415#ENSG00000136504#ENST00000454930#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000424577#ENSG00000136504#ENST00000509773#C2H2 ZF Containing Proteins#MOZ_SAS$#ENSP00000423385#ENSG00000136504#ENST00000510819#C2H2 ZF Containing Proteins#MOZ_SAS	FALSE
292	ENSG00000176407	KCMF1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	No evidence of DNA-binding in the literature; and has evidence of E3 ligase activity (PMID:15581609).	IPR000433;IPR007087;IPR008598;IPR015880	56888	potassium channel modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:20589]	None	DBD and Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000386738#ENSG00000176407#ENST00000409785#C2H2 ZF Containing Proteins#Di19_C, ZZ$#ENSP00000409499#ENSG00000176407#ENST00000428691#C2H2 ZF Containing Proteins#$#ENSP00000391340#ENSG00000176407#ENST00000453448#C2H2 ZF Containing Proteins#zf-ribbon_3$#ENSP00000414214#ENSG00000176407#ENST00000456682#C2H2 ZF Containing Proteins#	FALSE
293	ENSG00000151657	KIN	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Binds curved DNA (PMID: 8078469).	IPR019447;	22944	Kin17 DNA and RNA binding protein [Source:HGNC Symbol;Acc:HGNC:6327]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000368881#ENSG00000151657#ENST00000379562#Other#KOW, Kin17_mid	FALSE
294	ENSG00000105610	KLF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	10661	Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11092887	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000105610#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8924208, PMID:9778250	$#ENSP00000264834#ENSG00000105610#ENST00000264834#C2H2 ZF Containing Proteins#EKLF_TAD1, EKLF_TAD2	FALSE
295	ENSG00000155090	KLF10	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7071	Kruppel like factor 10 [Source:HGNC Symbol;Acc:HGNC:11810]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15087465	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000155090#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10816551, PMID:9748269	$#ENSP00000285407#ENSG00000155090#ENST00000285407#C2H2 ZF Containing Proteins#AAA_33$#ENSP00000379222#ENSG00000155090#ENST00000395884#C2H2 ZF Containing Proteins#AAA_33	FALSE
296	ENSG00000172059	KLF11	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	8462	Kruppel like factor 11 [Source:HGNC Symbol;Acc:HGNC:11811]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000172059#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:21171965$#ENSG00000172059#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9748269	$#ENSP00000307023#ENSG00000172059#ENST00000305883#C2H2 ZF Containing Proteins#$#ENSP00000388263#ENSG00000172059#ENST00000440320#C2H2 ZF Containing Proteins#$#ENSP00000442722#ENSG00000172059#ENST00000535335#C2H2 ZF Containing Proteins#$#ENSP00000444690#ENSG00000172059#ENST00000540845#C2H2 ZF Containing Proteins#$#ENSP00000386058#ENSG00000172059#ENST00000401510#C2H2 ZF Containing Proteins#	FALSE
297	ENSG00000118922	KLF12	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	11278	Kruppel like factor 12 [Source:HGNC Symbol;Acc:HGNC:6346]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:9858544	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000118922#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000118922#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16615998	$#ENSP00000366897#ENSG00000118922#ENST00000377669#C2H2 ZF Containing Proteins#	FALSE
298	ENSG00000169926	KLF13	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	51621	Kruppel like factor 13 [Source:HGNC Symbol;Acc:HGNC:13672]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10642511;16303770	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000169926#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000302456#ENSG00000169926#ENST00000307145#C2H2 ZF Containing Proteins#$#ENSP00000452867#ENSG00000169926#ENST00000558844#C2H2 ZF Containing Proteins#$#ENSP00000452609#ENSG00000169926#ENST00000560473#C2H2 ZF Containing Proteins#	FALSE
299	ENSG00000266265	KLF14	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	136259	Kruppel like factor 14 [Source:HGNC Symbol;Acc:HGNC:23025]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000463287#ENSG00000266265#ENST00000583337#C2H2 ZF Containing Proteins#	FALSE
300	ENSG00000163884	KLF15	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	28999	Kruppel like factor 15 [Source:HGNC Symbol;Acc:HGNC:14536]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:12097321;17438289	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000163884#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - PMID:19767294	$#ENSP00000296233#ENSG00000163884#ENST00000296233#C2H2 ZF Containing Proteins#	FALSE
301	ENSG00000129911	KLF16	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	83855	Kruppel like factor 16 [Source:HGNC Symbol;Acc:HGNC:16857]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12036432	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000129911#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000483701#ENSG00000129911#ENST00000617223#C2H2 ZF Containing Proteins#$#ENSP00000250916#ENSG00000129911#ENST00000250916#C2H2 ZF Containing Proteins#$#ENSP00000480570#ENSG00000129911#ENST00000592313#C2H2 ZF Containing Proteins#	FALSE
302	ENSG00000171872	KLF17	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	128209	Kruppel like factor 17 [Source:HGNC Symbol;Acc:HGNC:18830]	None	DBD	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000171872#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000171872#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000361373#ENSG00000171872#ENST00000372299#C2H2 ZF Containing Proteins#	FALSE
303	ENSG00000127528	KLF2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	10365	Kruppel like factor 2 [Source:HGNC Symbol;Acc:HGNC:6347]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000127528#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:21063504	$#ENSP00000248071#ENSG00000127528#ENST00000248071#C2H2 ZF Containing Proteins#$#ENSP00000465035#ENSG00000127528#ENST00000592003#C2H2 ZF Containing Proteins#	FALSE
304	ENSG00000109787	KLF3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	51274	Kruppel like factor 3 [Source:HGNC Symbol;Acc:HGNC:16516]	None	DBD	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000109787#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10582345	$#ENSP00000261438#ENSG00000109787#ENST00000261438#C2H2 ZF Containing Proteins#$#ENSP00000421252#ENSG00000109787#ENST00000514033#C2H2 ZF Containing Proteins#	FALSE
305	ENSG00000136826	KLF4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	9314	Kruppel like factor 4 [Source:HGNC Symbol;Acc:HGNC:6348]	2WBS	DBD and Full	not tested	None	Structure is crystalized with too short DNA and only one of the domains contact DNA properly	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000136826#GO:0001010#sequence-specific DNA binding transcription factor recruiting transcription factor activity#ISS - GO_REF:0000024$#ENSG00000136826#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:21539536$#ENSG00000136826#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9422764$#ENSG00000136826#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20551324	$#ENSP00000363804#ENSG00000136826#ENST00000374672#C2H2 ZF Containing Proteins#$#ENSP00000399921#ENSG00000136826#ENST00000411706#C2H2 ZF Containing Proteins#$#ENSP00000404922#ENSG00000136826#ENST00000420475#C2H2 ZF Containing Proteins#$#ENSP00000483629#ENSG00000136826#ENST00000610832#C2H2 ZF Containing Proteins#	FALSE
306	ENSG00000102554	KLF5	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Binds as a monomer and as a dimer (PMID: 25575120).	IPR007087;IPR015880	688	Kruppel like factor 5 [Source:HGNC Symbol;Acc:HGNC:6349]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16595680	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000102554#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16595680	$#ENSP00000366915#ENSG00000102554#ENST00000377687#C2H2 ZF Containing Proteins#$#ENSP00000440407#ENSG00000102554#ENST00000539231#C2H2 ZF Containing Proteins#	FALSE
307	ENSG00000067082	KLF6	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	1316	Kruppel like factor 6 [Source:HGNC Symbol;Acc:HGNC:2235]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Pratyush Das	Yes	None	$#ENSP00000419079#ENSG00000067082#ENST00000469435#C2H2 ZF Containing Proteins#$#ENSP00000419923#ENSG00000067082#ENST00000497571#C2H2 ZF Containing Proteins#$#ENSP00000445301#ENSG00000067082#ENST00000542957#C2H2 ZF Containing Proteins#	FALSE
308	ENSG00000118263	KLF7	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR007087;IPR015880	8609	Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9774444	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000118263#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000309570#ENSG00000118263#ENST00000309446#C2H2 ZF Containing Proteins#$#ENSP00000387510#ENSG00000118263#ENST00000421199#C2H2 ZF Containing Proteins#$#ENSP00000398572#ENSG00000118263#ENST00000423015#C2H2 ZF Containing Proteins#$#ENSP00000393268#ENSG00000118263#ENST00000458272#C2H2 ZF Containing Proteins#$#ENSP00000403284#ENSG00000118263#ENST00000412414#C2H2 ZF Containing Proteins#$#ENSP00000413590#ENSG00000118263#ENST00000435602#C2H2 ZF Containing Proteins#	FALSE
309	ENSG00000102349	KLF8	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR007087;IPR015880	11279	Kruppel like factor 8 [Source:HGNC Symbol;Acc:HGNC:6351]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000417303#ENSG00000102349#ENST00000468660#C2H2 ZF Containing Proteins#$#ENSP00000364063#ENSG00000102349#ENST00000374928#C2H2 ZF Containing Proteins#	FALSE
310	ENSG00000119138	KLF9	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR007087;IPR015880	687	Kruppel like factor 9 [Source:HGNC Symbol;Acc:HGNC:1123]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9858544;11751593	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000119138#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1356762, PMID:8051167	$#ENSP00000366330#ENSG00000119138#ENST00000377126#C2H2 ZF Containing Proteins#	FALSE
311	ENSG00000185513	L3MBTL1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Histone modifier; polycomb protein.	IPR001660;IPR002515;IPR004092;IPR013761;IPR021129;	26013	L(3)mbt-like 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:15905]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000185513#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000362226#ENSG00000185513#ENST00000373134#C2H2 ZF Containing Proteins#MBT$#ENSP00000362227#ENSG00000185513#ENST00000373135#C2H2 ZF Containing Proteins#MBT$#ENSP00000398516#ENSG00000185513#ENST00000418998#C2H2 ZF Containing Proteins#MBT$#ENSP00000410139#ENSG00000185513#ENST00000422861#C2H2 ZF Containing Proteins#MBT, SAM_1	FALSE
312	ENSG00000198945	L3MBTL3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Histone modifier; polycomb protein.	IPR001660;IPR004092;IPR013761;IPR021129	84456	l(3)mbt-like 3 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:23035]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000437185#ENSG00000198945#ENST00000533560#C2H2 ZF Containing Proteins#Glyco_hydro_2_N, MBT, SAM_1, SAM_2	FALSE
313	ENSG00000154655	L3MBTL4	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Histone modifier; polycomb protein.	IPR001660;IPR002515;IPR004092;IPR013761;IPR021129;	91133	l(3)mbt-like 4 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:26677]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000154655#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000382975#ENSG00000154655#ENST00000400104#C2H2 ZF Containing Proteins#MBT$#ENSP00000382976#ENSG00000154655#ENST00000400105#C2H2 ZF Containing Proteins#MBT, SAM_1, SAM_2$#ENSP00000462090#ENSG00000154655#ENST00000583809#C2H2 ZF Containing Proteins#MBT	FALSE
314	ENSG00000103495	MAZ	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	4150	MYC associated zinc finger protein [Source:HGNC Symbol;Acc:HGNC:6914]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1454839;15094381	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000219782#ENSG00000103495#ENST00000219782#C2H2 ZF Containing Proteins#$#ENSP00000313362#ENSG00000103495#ENST00000322945#C2H2 ZF Containing Proteins#$#ENSP00000443956#ENSG00000103495#ENST00000545521#C2H2 ZF Containing Proteins#$#ENSP00000460877#ENSG00000103495#ENST00000569978#C2H2 ZF Containing Proteins#$#ENSP00000460057#ENSG00000103495#ENST00000567444#C2H2 ZF Containing Proteins#zf-C2H2_jaz$#ENSP00000455473#ENSG00000103495#ENST00000568544#C2H2 ZF Containing Proteins#$#ENSP00000455726#ENSG00000103495#ENST00000562337#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-RING_10$#ENSP00000461630#ENSG00000103495#ENST00000562557#C2H2 ZF Containing Proteins#$#ENSP00000455913#ENSG00000103495#ENST00000563012#C2H2 ZF Containing Proteins#$#ENSP00000455794#ENSG00000103495#ENST00000568411#C2H2 ZF Containing Proteins#zf-C2H2_jaz	FALSE
315	ENSG00000085276	MECOM	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001214;IPR007087;IPR015880;	2122	MDS1 and EVI1 complex locus [Source:HGNC Symbol;Acc:HGNC:3498]	None	not tested	not tested	None	PMID: 8321231 SELEX model that is also in Jaspar, Direct	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15889140	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000085276#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19767769	$#ENSP00000264674#ENSG00000085276#ENST00000264674#C2H2 ZF Containing Proteins#$#ENSP00000394302#ENSG00000085276#ENST00000433243#C2H2 ZF Containing Proteins#$#ENSP00000420466#ENSG00000085276#ENST00000460814#C2H2 ZF Containing Proteins#$#ENSP00000417922#ENSG00000085276#ENST00000460890#C2H2 ZF Containing Proteins#$#ENSP00000419770#ENSG00000085276#ENST00000464456#C2H2 ZF Containing Proteins#$#ENSP00000418689#ENSG00000085276#ENST00000466623#C2H2 ZF Containing Proteins#$#ENSP00000419757#ENSG00000085276#ENST00000487503#C2H2 ZF Containing Proteins#$#ENSP00000420072#ENSG00000085276#ENST00000494597#C2H2 ZF Containing Proteins#$#ENSP00000486104#ENSG00000085276#ENST00000628990#C2H2 ZF Containing Proteins#$#ENSP00000419995#ENSG00000085276#ENST00000468789#C2H2 ZF Containing Proteins#	FALSE
316	ENSG00000188786	MTF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	4520	metal-regulatory transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:7428]	None	DBD and Full	Yes	None	PMID: 23012419 suggests that different types of metal ions function as allosteric modulators for this TF	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7610056;16221973	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000188786#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9582278$#ENSG00000188786#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:3208749	$#ENSP00000362127#ENSG00000188786#ENST00000373036#C2H2 ZF Containing Proteins#Marek_A	FALSE
317	ENSG00000085274	MYNN	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	55892	myoneurin [Source:HGNC Symbol;Acc:HGNC:14955]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000085274#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10873615	$#ENSP00000326240#ENSG00000085274#ENST00000349841#C2H2 ZF Containing Proteins#BTB$#ENSP00000349150#ENSG00000085274#ENST00000356716#C2H2 ZF Containing Proteins#BTB$#ENSP00000440637#ENSG00000085274#ENST00000544106#C2H2 ZF Containing Proteins#BTB	FALSE
318	ENSG00000196132	MYT1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Crystal structure (PDB:2JX1) has GTGAACTTTCGGT DNA; similar to MYT1L SELEX and PBM sites.	IPR002515;IPR013681	4661	myelin transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:7622]	2JX1	DBD and Full	not tested	None	Crystal has GTGAACTTTCGGT DNA, similar to MYT1L SELEX and PBM sites	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8980226	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000196132#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1280325	$#ENSP00000327465#ENSG00000196132#ENST00000328439#C2H2 ZF Containing Proteins#DUF812, MYT1$#ENSP00000353269#ENSG00000196132#ENST00000360149#C2H2 ZF Containing Proteins#MYT1$#ENSP00000442412#ENSG00000196132#ENST00000536311#C2H2 ZF Containing Proteins#DUF812, MYT1$#ENSP00000480510#ENSG00000196132#ENST00000622439#C2H2 ZF Containing Proteins#MYT1	FALSE
319	ENSG00000186487	MYT1L	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002515;IPR013681	23040	myelin transcription factor 1 like [Source:HGNC Symbol;Acc:HGNC:7623]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8631881;15935060	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000186487#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000382114#ENSG00000186487#ENST00000399161#C2H2 ZF Containing Proteins#APG6, MYT1$#ENSP00000384219#ENSG00000186487#ENST00000407844#C2H2 ZF Containing Proteins#DUF342, DivIC$#ENSP00000396103#ENSG00000186487#ENST00000428368#C2H2 ZF Containing Proteins#APG6, MYT1$#ENSP00000382111#ENSG00000186487#ENST00000399157#C2H2 ZF Containing Proteins#APG6, ATG16, CALCOCO1, DUF342, DUF812, DivIC, FAM7	FALSE
320	ENSG00000099326	MZF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR003309;IPR007087;IPR008916;IPR015880	7593	myeloid zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13108]	None	not tested	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7579328	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000099326#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7579328$#ENSG00000099326#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7579328$#ENSG00000099326#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1860835	$#ENSP00000215057#ENSG00000099326#ENST00000215057#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472123#ENSG00000099326#ENST00000594108#C2H2 ZF Containing Proteins#SCAN$#ENSP00000469378#ENSG00000099326#ENST00000594234#C2H2 ZF Containing Proteins#SCAN$#ENSP00000469493#ENSG00000099326#ENST00000599369#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472454#ENSG00000099326#ENST00000596039#C2H2 ZF Containing Proteins#SCAN	FALSE
321	ENSG00000083635	NUFIP1	C2H2 ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	Single C2H2 domain	This is a known RNA-binding protein with a single C2H2 domain.  TF-CAT considered it a candidate TF; but in the ten years since; no such evidence has emerged.	IPR007087;IPR015880;IPR019496;IPR022755	26747	NUFIP1, FMR1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8057]	None	not tested	not tested	None	None	x	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:12941608;15107825	No	4a, two or more datasets predict it as a TF	Pratyush Das	Tim Hughes	No	None	$#ENSP00000368459#ENSG00000083635#ENST00000379161#C2H2 ZF Containing Proteins#NUFIP1	FALSE
322	ENSG00000143867	OSR1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	130497	odd-skipped related transciption factor 1 [Source:HGNC Symbol;Acc:HGNC:8111]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000272223#ENSG00000143867#ENST00000272223#C2H2 ZF Containing Proteins#	FALSE
323	ENSG00000164920	OSR2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	116039	odd-skipped related transciption factor 2 [Source:HGNC Symbol;Acc:HGNC:15830]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000164920#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000297565#ENSG00000164920#ENST00000297565#C2H2 ZF Containing Proteins#$#ENSP00000402862#ENSG00000164920#ENST00000435298#C2H2 ZF Containing Proteins#$#ENSP00000430041#ENSG00000164920#ENST00000523368#C2H2 ZF Containing Proteins#$#ENSP00000414657#ENSG00000164920#ENST00000457907#C2H2 ZF Containing Proteins#$#ENSP00000430780#ENSG00000164920#ENST00000522510#C2H2 ZF Containing Proteins#$#ENSP00000429910#ENSG00000164920#ENST00000518199#C2H2 ZF Containing Proteins#$#ENSP00000430074#ENSG00000164920#ENST00000520951#C2H2 ZF Containing Proteins#	FALSE
324	ENSG00000172818	OVOL1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	5017	ovo like transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:8525]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:17311813	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000172818#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000172818#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000337862#ENSG00000172818#ENST00000335987#C2H2 ZF Containing Proteins#$#ENSP00000434220#ENSG00000172818#ENST00000532448#C2H2 ZF Containing Proteins#	FALSE
325	ENSG00000125850	OVOL2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	58495	ovo like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:15804]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11983900;15225875	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000125850#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000125850#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000278780#ENSG00000125850#ENST00000278780#C2H2 ZF Containing Proteins#	FALSE
326	ENSG00000105261	OVOL3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	728361	ovo like zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:14186]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000105261#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000465620#ENSG00000105261#ENST00000585332#C2H2 ZF Containing Proteins#$#ENSP00000487603#ENSG00000105261#ENST00000633214#C2H2 ZF Containing Proteins#	FALSE
327	ENSG00000198300	PEG3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	SCAN C2H2 ZF Protein.	IPR003309;IPR007087;IPR008916;IPR015880	5178	paternally expressed 3 [Source:HGNC Symbol;Acc:HGNC:8826]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000198300#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000326581#ENSG00000198300#ENST00000326441#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472402#ENSG00000198300#ENST00000593695#C2H2 ZF Containing Proteins#$#ENSP00000473190#ENSG00000198300#ENST00000598410#C2H2 ZF Containing Proteins#$#ENSP00000472395#ENSG00000198300#ENST00000599534#C2H2 ZF Containing Proteins#SCAN$#ENSP00000469486#ENSG00000198300#ENST00000599577#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470467#ENSG00000198300#ENST00000600833#C2H2 ZF Containing Proteins#$#ENSP00000469144#ENSG00000198300#ENST00000594389#C2H2 ZF Containing Proteins#	FALSE
328	ENSG00000181690	PLAG1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	5324	PLAG1 zinc finger [Source:HGNC Symbol;Acc:HGNC:9045]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10646861	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000181690#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10646861$#ENSG00000181690#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9722527	$#ENSP00000325546#ENSG00000181690#ENST00000316981#C2H2 ZF Containing Proteins#$#ENSP00000416537#ENSG00000181690#ENST00000429357#C2H2 ZF Containing Proteins#$#ENSP00000404067#ENSG00000181690#ENST00000423799#C2H2 ZF Containing Proteins#	FALSE
329	ENSG00000118495	PLAGL1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	5325	PLAG1 like zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:9046]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9671765;9722527	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000118495#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9671765	$#ENSP00000346810#ENSG00000118495#ENST00000354765#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000356543#ENSG00000118495#ENST00000367571#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000356544#ENSG00000118495#ENST00000367572#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000376124#ENSG00000118495#ENST00000392307#C2H2 ZF Containing Proteins#$#ENSP00000400060#ENSG00000118495#ENST00000416623#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000395960#ENSG00000118495#ENST00000417959#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000392418#ENSG00000118495#ENST00000437412#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000400929#ENSG00000118495#ENST00000444202#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000487447#ENSG00000118495#ENST00000626294#C2H2 ZF Containing Proteins#$#ENSP00000486711#ENSG00000118495#ENST00000626373#C2H2 ZF Containing Proteins#$#ENSP00000486763#ENSG00000118495#ENST00000629195#C2H2 ZF Containing Proteins#$#ENSP00000486355#ENSG00000118495#ENST00000625622#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
330	ENSG00000126003	PLAGL2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	5326	PLAG1 like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:9047]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__Transactivation_PMIDS:9722527	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000126003#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15361364$#ENSG00000126003#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9722527	$#ENSP00000246229#ENSG00000126003#ENST00000246229#C2H2 ZF Containing Proteins#	FALSE
331	ENSG00000057657	PRDM1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001214;IPR007087;IPR015880;IPR016608	639	PR domain 1 [Source:HGNC Symbol;Acc:HGNC:9346]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1851123	Yes	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000057657#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:1851123$#ENSG00000057657#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1851123	$#ENSP00000358085#ENSG00000057657#ENST00000369089#C2H2 ZF Containing Proteins#SET$#ENSP00000358087#ENSG00000057657#ENST00000369091#C2H2 ZF Containing Proteins#SET$#ENSP00000358092#ENSG00000057657#ENST00000369096#C2H2 ZF Containing Proteins#SET$#ENSP00000399772#ENSG00000057657#ENST00000450060#C2H2 ZF Containing Proteins#SET	FALSE
332	ENSG00000170325	PRDM10	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	IPR001214;IPR007087;IPR015880;IPR022755	56980	PR domain 10 [Source:HGNC Symbol;Acc:HGNC:13995]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000302669#ENSG00000170325#ENST00000304538#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000351686#ENSG00000170325#ENST00000358825#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000354118#ENSG00000170325#ENST00000360871#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000398431#ENSG00000170325#ENST00000423662#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000432237#ENSG00000170325#ENST00000526082#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000435940#ENSG00000170325#ENST00000533431#C2H2 ZF Containing Proteins#Tristanin_u2$#ENSP00000432093#ENSG00000170325#ENST00000527581#C2H2 ZF Containing Proteins#	FALSE
333	ENSG00000130711	PRDM12	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001214;IPR007087;IPR015880;IPR017126	59335	PR domain 12 [Source:HGNC Symbol;Acc:HGNC:13997]	None	DBD	not tested	None	None	b	Yes	No	No	2a1, Lower confidence direct evidence	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000253008#ENSG00000130711#ENST00000253008#C2H2 ZF Containing Proteins#SET	FALSE
334	ENSG00000112238	PRDM13	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001214;IPR007087;IPR015880;	59336	PR domain 13 [Source:HGNC Symbol;Acc:HGNC:13998]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000358217#ENSG00000112238#ENST00000369215#C2H2 ZF Containing Proteins#SET	FALSE
335	ENSG00000147596	PRDM14	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001214;IPR007087;IPR015880;	63978	PR domain 14 [Source:HGNC Symbol;Acc:HGNC:14001]	None	Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000276594#ENSG00000147596#ENST00000276594#C2H2 ZF Containing Proteins#SET$#ENSP00000408653#ENSG00000147596#ENST00000426346#C2H2 ZF Containing Proteins#	FALSE
336	ENSG00000141956	PRDM15	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001214;IPR007087;IPR015880;	63977	PR domain 15 [Source:HGNC Symbol;Acc:HGNC:13999]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000141956#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000269844#ENSG00000141956#ENST00000269844#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6$#ENSP00000381556#ENSG00000141956#ENST00000398548#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000408592#ENSG00000141956#ENST00000422911#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000390245#ENSG00000141956#ENST00000447207#C2H2 ZF Containing Proteins#SET, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz	FALSE
337	ENSG00000142611	PRDM16	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001214;IPR007087;IPR015880;	63976	PR domain 16 [Source:HGNC Symbol;Acc:HGNC:14000]	None	not tested	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000270722#ENSG00000142611#ENST00000270722#C2H2 ZF Containing Proteins#SET$#ENSP00000367643#ENSG00000142611#ENST00000378391#C2H2 ZF Containing Proteins#SET	FALSE
338	ENSG00000116731	PRDM2	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has been suggested to function as a histone methyltransferase (PMID: 15282304), but it has a decent set of C2H2 ZF domains and could thus bind DNA independently.	IPR001214;IPR007087;IPR009170;IPR015880	7799	PR domain 2 [Source:HGNC Symbol;Acc:HGNC:9347]	None	not tested	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000116731#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7590293, PMID:8654390	$#ENSP00000235372#ENSG00000116731#ENST00000235372#C2H2 ZF Containing Proteins#SET$#ENSP00000341621#ENSG00000116731#ENST00000343137#C2H2 ZF Containing Proteins#$#ENSP00000411103#ENSG00000116731#ENST00000413440#C2H2 ZF Containing Proteins#$#ENSP00000425028#ENSG00000116731#ENST00000503842#C2H2 ZF Containing Proteins#$#ENSP00000426737#ENSG00000116731#ENST00000505823#C2H2 ZF Containing Proteins#$#ENSP00000365216#ENSG00000116731#ENST00000376048#C2H2 ZF Containing Proteins#SET$#ENSP00000474273#ENSG00000116731#ENST00000487453#C2H2 ZF Containing Proteins#	FALSE
339	ENSG00000110851	PRDM4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001214;IPR007087;IPR015880;IPR017124	11108	PR domain 4 [Source:HGNC Symbol;Acc:HGNC:9348]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000228437#ENSG00000110851#ENST00000228437#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-met$#ENSP00000448684#ENSG00000110851#ENST00000547188#C2H2 ZF Containing Proteins#$#ENSP00000449295#ENSG00000110851#ENST00000550659#C2H2 ZF Containing Proteins#	FALSE
340	ENSG00000138738	PRDM5	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of C2H2 ZF domains. Moreover, (PMID: 17636019) has performed SELEX for it and validated the result.	IPR001214;IPR007087;IPR015880;IPR017125;IPR022755;	11107	PR domain 5 [Source:HGNC Symbol;Acc:HGNC:9349]	None	Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000138738#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17636019	$#ENSP00000264808#ENSG00000138738#ENST00000264808#C2H2 ZF Containing Proteins#$#ENSP00000377955#ENSG00000138738#ENST00000394435#C2H2 ZF Containing Proteins#$#ENSP00000404832#ENSG00000138738#ENST00000428209#C2H2 ZF Containing Proteins#$#ENSP00000422309#ENSG00000138738#ENST00000515109#C2H2 ZF Containing Proteins#	FALSE
341	ENSG00000061455	PRDM6	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001214;IPR007087;IPR015880;	93166	PR domain 6 [Source:HGNC Symbol;Acc:HGNC:9350]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000384725#ENSG00000061455#ENST00000407847#C2H2 ZF Containing Proteins#SET	FALSE
342	ENSG00000152784	PRDM8	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001214;IPR007087;IPR015880;	56978	PR domain 8 [Source:HGNC Symbol;Acc:HGNC:13993]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000339764#ENSG00000152784#ENST00000339711#C2H2 ZF Containing Proteins#SET, zf-H2C2_2$#ENSP00000406998#ENSG00000152784#ENST00000415738#C2H2 ZF Containing Proteins#SET, zf-H2C2_2$#ENSP00000425149#ENSG00000152784#ENST00000515013#C2H2 ZF Containing Proteins#SET$#ENSP00000423985#ENSG00000152784#ENST00000504452#C2H2 ZF Containing Proteins#SET, zf-H2C2_2	FALSE
343	ENSG00000164256	PRDM9	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001214;IPR001909;IPR003655;IPR007087;IPR015880;IPR019041	56979	PR domain 9 [Source:HGNC Symbol;Acc:HGNC:13994]	5EGB	not tested	not tested	None	Structure is fine	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000296682#ENSG00000164256#ENST00000296682#C2H2 ZF Containing Proteins#KRAB, SET, SSXRD, zf-C2H2_4$#ENSP00000425471#ENSG00000164256#ENST00000502755#C2H2 ZF Containing Proteins#KRAB, Phage_F$#ENSP00000489227#ENSG00000164256#ENST00000635252#C2H2 ZF Containing Proteins#SET, SSXRD	TRUE
344	ENSG00000185238	PRMT3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Has a single C2H2 ZF (PMID: 10931850).	IPR007087;IPR025799;IPR029063;	10196	Protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000331879#ENSG00000185238#ENST00000331079#Other#FtsJ, MTS, Met_10, Methyltransf_11, Methyltransf_1$#ENSP00000397766#ENSG00000185238#ENST00000437750#Other#FtsJ, MTS, Met_10, Methyltransf_11, Methyltransf_1	FALSE
345	ENSG00000146587	RBAK	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	57786	RB associated KRAB zinc finger [Source:HGNC Symbol;Acc:HGNC:17680]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14664718	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000380120#ENSG00000146587#ENST00000396912#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_6, zinc_ribbon_15$#ENSP00000275423#ENSG00000146587#ENST00000353796#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_6, zinc_ribbon_15	TRUE
346	ENSG00000131381	RBSN	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Potential false positive - protein functions in membrane trafficking.	IPR000306;IPR007087;IPR011011;IPR017455;IPR021565;	64145	rabenosyn, RAB effector [Source:HGNC Symbol;Acc:HGNC:20759]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000253699#ENSG00000131381#ENST00000253699#C2H2 ZF Containing Proteins#FYVE, NPF, Rbsn$#ENSP00000387724#ENSG00000131381#ENST00000449050#C2H2 ZF Containing Proteins#zf-Di19$#ENSP00000422551#ENSG00000131381#ENST00000476527#C2H2 ZF Containing Proteins#FYVE, NPF, Rbsn$#ENSP00000427038#ENSG00000131381#ENST00000507357#C2H2 ZF Containing Proteins#zf-AD, zf-Di19	FALSE
347	ENSG00000214022	REPIN1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds DNA specifically based on EMSA and nuclease footprinting (PMID: 10606657).	IPR007087;IPR015880	29803	replication initiator 1 [Source:HGNC Symbol;Acc:HGNC:17922]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000407714#ENSG00000214022#ENST00000444957#C2H2 ZF Containing Proteins#$#ENSP00000418507#ENSG00000214022#ENST00000466559#C2H2 ZF Containing Proteins#$#ENSP00000380451#ENSG00000214022#ENST00000397281#C2H2 ZF Containing Proteins#$#ENSP00000420578#ENSG00000214022#ENST00000479668#C2H2 ZF Containing Proteins#$#ENSP00000417982#ENSG00000214022#ENST00000482680#C2H2 ZF Containing Proteins#$#ENSP00000417291#ENSG00000214022#ENST00000489432#C2H2 ZF Containing Proteins#$#ENSP00000428129#ENSG00000214022#ENST00000518514#C2H2 ZF Containing Proteins#$#ENSP00000388287#ENSG00000214022#ENST00000425389#C2H2 ZF Containing Proteins#	FALSE
348	ENSG00000084093	REST	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	5978	RE1 silencing transcription factor [Source:HGNC Symbol;Acc:HGNC:9966]	None	Full	Yes	None	Jaspar ChIP-seq model has a robust and specific signal	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15240883	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000084093#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10449787, PMID:10734093, PMID:21284946$#ENSG00000084093#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000084093#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19342457	$#ENSP00000311816#ENSG00000084093#ENST00000309042#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_5$#ENSP00000479151#ENSG00000084093#ENST00000611211#C2H2 ZF Containing Proteins#$#ENSP00000484836#ENSG00000084093#ENST00000619101#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_5$#ENSP00000481650#ENSG00000084093#ENST00000622863#C2H2 ZF Containing Proteins#	FALSE
349	ENSG00000117000	RLF	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	6018	rearranged L-myc fusion [Source:HGNC Symbol;Acc:HGNC:10025]	None	Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000361857#ENSG00000117000#ENST00000372771#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
350	ENSG00000124782	RREB1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	6239	ras responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:10449]	None	Full	not tested	None	SELEX model looks like an nonspecific or artifact	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8816445	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000124782#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000335574#ENSG00000124782#ENST00000334984#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000305560#ENSG00000124782#ENST00000349384#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000369265#ENSG00000124782#ENST00000379933#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000369270#ENSG00000124782#ENST00000379938#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000419511#ENSG00000124782#ENST00000483150#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-met	FALSE
351	ENSG00000103449	SALL1	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	6299	spalt like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10524]	None	DBD	not tested	None	None	a	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Other; TF PPI_PMIDS:11836251	Yes	2a2, orthologous lower confidence evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000103449#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:9425907	$#ENSP00000251020#ENSG00000103449#ENST00000251020#C2H2 ZF Containing Proteins#IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met$#ENSP00000455582#ENSG00000103449#ENST00000566102#C2H2 ZF Containing Proteins#$#ENSP00000407914#ENSG00000103449#ENST00000440970#C2H2 ZF Containing Proteins#IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met$#ENSP00000456777#ENSG00000103449#ENST00000570206#C2H2 ZF Containing Proteins#IZUMO, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-met	FALSE
352	ENSG00000165821	SALL2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	6297	Spalt like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10526	None	Full	Yes	None	None	a	Yes	No	No	2a1, Lower confidence direct evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000165821#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000484460#ENSG00000165821#ENST00000611430#C2H2 ZF Containing Proteins#$#ENSP00000483562#ENSG00000165821#ENST00000614342#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-Di19$#ENSP00000396773#ENSG00000165821#ENST00000450879#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000438493#ENSG00000165821#ENST00000537235#C2H2 ZF Containing Proteins#DUF2076$#ENSP00000439654#ENSG00000165821#ENST00000541965#C2H2 ZF Containing Proteins#DUF2076$#ENSP00000440054#ENSG00000165821#ENST00000546363#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000483202#ENSG00000165821#ENST00000613414#C2H2 ZF Containing Proteins#	FALSE
353	ENSG00000256463	SALL3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	27164	spalt like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10527]	None	not tested	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000256463#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000256463##C2H2 ZF Containing Proteins#	FALSE
354	ENSG00000101115	SALL4	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	57167	spalt like transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:15924]	None	Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation_PMIDS:16380715;1684	Yes	2a2, orthologous lower confidence evidence	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000101115#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000217086#ENSG00000101115#ENST00000217086#C2H2 ZF Containing Proteins#NinF$#ENSP00000360594#ENSG00000101115#ENST00000371539#C2H2 ZF Containing Proteins#$#ENSP00000379319#ENSG00000101115#ENST00000395997#C2H2 ZF Containing Proteins#NinF	FALSE
355	ENSG00000261678	SCRT1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	83482	Scratch family transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:15950]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000261678#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11274425	$#ENSP00000455711#ENSG00000261678#ENST00000569446#C2H2 ZF Containing Proteins#	FALSE
356	ENSG00000215397	SCRT2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	85508	scratch family transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:15952]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000215397#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - PMID:21252910	$#ENSP00000246104#ENSG00000215397#ENST00000246104#C2H2 ZF Containing Proteins#	FALSE
357	ENSG00000125520	SLC2A4RG	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Two papers demonstrate a bit of evidence for DNA binding (PMID:10825161 and PMID: 14625278 ).	IPR007087;IPR015880	56731	SLC2A4 regulator [Source:HGNC Symbol;Acc:HGNC:15930]	None	Full	not tested	None	None	x	Yes	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Sam Lambert	No	$#ENSG00000125520#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10825161	$#ENSP00000266077#ENSG00000125520#ENST00000266077#C2H2 ZF Containing Proteins#	FALSE
358	ENSG00000124216	SNAI1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	6615	snail family transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:11128]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12917416;14673164;12917416;16158046;16801545;17359298	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000124216#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11912130	$#ENSP00000244050#ENSG00000124216#ENST00000244050#C2H2 ZF Containing Proteins#	FALSE
359	ENSG00000019549	SNAI2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	6591	snail family transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:11094]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10518215;16286009	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000019549#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10866665, PMID:11912130, PMID:16707493,$#ENSG00000019549#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000020945#ENSG00000019549#ENST00000020945#C2H2 ZF Containing Proteins#$#ENSP00000380034#ENSG00000019549#ENST00000396822#C2H2 ZF Containing Proteins#	FALSE
360	ENSG00000185669	SNAI3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002355;IPR007087;IPR015880;	333929	snail family transcriptional repressor 3 [Source:HGNC Symbol;Acc:HGNC:18411]	None	Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10606664	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000185669#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000185669#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000327968#ENSG00000185669#ENST00000332281#C2H2 ZF Containing Proteins#	FALSE
361	ENSG00000185591	SP1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	6667	Sp1 transcription factor [Source:HGNC Symbol;Acc:HGNC:11205]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15282343;15589828	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000185591#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21659522$#ENSG00000185591#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12169688, PMID:12560508	$#ENSP00000329357#ENSG00000185591#ENST00000327443#C2H2 ZF Containing Proteins#$#ENSP00000404263#ENSG00000185591#ENST00000426431#C2H2 ZF Containing Proteins#$#ENSP00000458133#ENSG00000185591#ENST00000548560#C2H2 ZF Containing Proteins#$#ENSP00000457804#ENSG00000185591#ENST00000551969#C2H2 ZF Containing Proteins#	FALSE
362	ENSG00000167182	SP2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	6668	Sp2 transcription factor [Source:HGNC Symbol;Acc:HGNC:11207]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000167182#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000365931#ENSG00000167182#ENST00000376741#C2H2 ZF Containing Proteins#$#ENSP00000489736#ENSG00000167182#ENST00000635868#C2H2 ZF Containing Proteins#$#ENSP00000490512#ENSG00000167182#ENST00000637314#C2H2 ZF Containing Proteins#$#ENSP00000490351#ENSG00000167182#ENST00000637943#C2H2 ZF Containing Proteins#	FALSE
363	ENSG00000172845	SP3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	6670	Sp3 transcription factor [Source:HGNC Symbol;Acc:HGNC:11208]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12591615	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000172845#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000172845#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000310301#ENSG00000172845#ENST00000310015#C2H2 ZF Containing Proteins#$#ENSP00000413665#ENSG00000172845#ENST00000416195#C2H2 ZF Containing Proteins#$#ENSP00000406140#ENSG00000172845#ENST00000418194#C2H2 ZF Containing Proteins#	FALSE
364	ENSG00000105866	SP4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	6671	Sp4 transcription factor [Source:HGNC Symbol;Acc:HGNC:11209]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15265862	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000105866#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000222584#ENSG00000105866#ENST00000222584#C2H2 ZF Containing Proteins#$#ENSP00000393623#ENSG00000105866#ENST00000432066#C2H2 ZF Containing Proteins#	FALSE
365	ENSG00000204335	SP5	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac motif has some similarity to known Sp1 TF motifs from multiple species and sources	IPR007087;IPR015880	389058	Sp5 transcription factor [Source:HGNC Symbol;Acc:HGNC:14529]	None	DBD	not tested	None	None	a	Yes	No	No	2a1, Lower confidence direct evidence	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000364430#ENSG00000204335#ENST00000375281#C2H2 ZF Containing Proteins#	FALSE
366	ENSG00000189120	SP6	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	80320	Sp6 transcription factor [Source:HGNC Symbol;Acc:HGNC:14530]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a2, Orthologous HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000340799#ENSG00000189120#ENST00000342234#C2H2 ZF Containing Proteins#$#ENSP00000438209#ENSG00000189120#ENST00000536300#C2H2 ZF Containing Proteins#	FALSE
367	ENSG00000170374	SP7	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	121340	Sp7 transcription factor [Source:HGNC Symbol;Acc:HGNC:17321]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:16041384	No	2a1, Lower confidence direct evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000302812#ENSG00000170374#ENST00000303846#C2H2 ZF Containing Proteins#$#ENSP00000441367#ENSG00000170374#ENST00000537210#C2H2 ZF Containing Proteins#$#ENSP00000443827#ENSG00000170374#ENST00000536324#C2H2 ZF Containing Proteins#$#ENSP00000449355#ENSG00000170374#ENST00000547755#C2H2 ZF Containing Proteins#	FALSE
368	ENSG00000164651	SP8	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	221833	Sp8 transcription factor [Source:HGNC Symbol;Acc:HGNC:19196]	None	DBD and Full	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000354482#ENSG00000164651#ENST00000361443#C2H2 ZF Containing Proteins#$#ENSP00000408792#ENSG00000164651#ENST00000418710#C2H2 ZF Containing Proteins#$#ENSP00000483588#ENSG00000164651#ENST00000617581#C2H2 ZF Containing Proteins#	FALSE
369	ENSG00000217236	SP9	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	100131390	Sp9 transcription factor [Source:HGNC Symbol;Acc:HGNC:30690]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000378418#ENSG00000217236#ENST00000394967#C2H2 ZF Containing Proteins#	FALSE
370	ENSG00000147488	ST18	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002515;IPR013681	9705	ST18, C2H2C-type zinc finger [Source:HGNC Symbol;Acc:HGNC:18695]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a2, Orthologous HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000147488#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000276480#ENSG00000147488#ENST00000276480#C2H2 ZF Containing Proteins#DUF812, MYT1$#ENSP00000428521#ENSG00000147488#ENST00000517580#C2H2 ZF Containing Proteins#MYT1$#ENSP00000428096#ENSG00000147488#ENST00000519118#C2H2 ZF Containing Proteins#	FALSE
371	ENSG00000135148	TRAFD1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Possible false positive: the protein negatively regulates IRF3 and NFKB but there is no evidence for DNA-binding and it is likely to operate upstream on the signalling cascade (PMID:18849341).	None	10906	TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24808]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$#ENSP00000396526#ENSG00000135148#ENST00000412615#Other#$#ENSP00000257604#ENSG00000135148#ENST00000257604#Other#$#ENSP00000473800#ENSG00000135148#ENST00000548092#Other#zf-TRAF$#ENSP00000450357#ENSG00000135148#ENST00000552896#Other#	FALSE
372	ENSG00000179981	TSHZ1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR007087;IPR015880;	10194	teashirt zinc finger homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10669]	None	DBD	not tested	None	PMID:25918232 Seems like a proper homeodomain with roles in olfactory bulb PMID:24487590 and pancreatic _-Cell maturation	b	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Pratyush Das	Yes	$#ENSG00000179981#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000323584#ENSG00000179981#ENST00000322038#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2HE$#ENSP00000464391#ENSG00000179981#ENST00000580243#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2HE$#ENSP00000452718#ENSG00000179981#ENST00000560661#C2H2 ZF Containing Proteins#$#ENSP00000453834#ENSG00000179981#ENST00000560918#C2H2 ZF Containing Proteins#	FALSE
373	ENSG00000182463	TSHZ2	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Also contains an atypical homodomain (Uniprot) not identified by Pfam.	IPR001356;IPR007087;IPR015880;	128553	teashirt zinc finger homeobox 2 [Source:HGNC Symbol;Acc:HGNC:13010]	None	DBD	not tested	None	PMID:24487590;PMID:25918232; Homolog to TSHZ1 that seems like a proper homeodomain with roles in olfactory bulb PMID:24487590 pancreatic _-Cell maturation PMID:25918232	b	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Pratyush Das	Sam Lambert	Yes	$#ENSG00000182463#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000360552#ENSG00000182463#ENST00000371497#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-met$#ENSP00000333114#ENSG00000182463#ENST00000329613#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-met$#ENSP00000475114#ENSG00000182463#ENST00000603338#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-met$#ENSP00000487408#ENSG00000182463#ENST00000626626#C2H2 ZF Containing Proteins#	FALSE
374	ENSG00000121297	TSHZ3	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	The C2H2 domains are too spread out to be credible; but there is also a homodomain.  Seems more likely than not that it binds DNA.	IPR001356;IPR007087;IPR015880;	57616	teashirt zinc finger homeobox 3 [Source:HGNC Symbol;Acc:HGNC:30700]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Tim Hughes	Yes	$#ENSG00000121297#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000240587#ENSG00000121297#ENST00000240587#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_6, zf-C2HE, zf-met$#ENSP00000475613#ENSG00000121297#ENST00000558569#C2H2 ZF Containing Proteins#	FALSE
375	ENSG00000136451	VEZF1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7716	vascular endothelial zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:12949]	None	not tested	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11504723	No	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000258963#ENSG00000136451#ENST00000258963#C2H2 ZF Containing Proteins#$#ENSP00000462337#ENSG00000136451#ENST00000581208#C2H2 ZF Containing Proteins#Spt20, zf-C2H2_4$#ENSP00000463631#ENSG00000136451#ENST00000583932#C2H2 ZF Containing Proteins#$#ENSP00000464687#ENSG00000136451#ENST00000584396#C2H2 ZF Containing Proteins#Spt20, zf-C2H2_4	FALSE
376	ENSG00000011451	WIZ	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Regulates the G9aGLP complex for gene repression; has a ChIP-seq derived DNA-binding motif (PMID:25789554).	IPR007087;IPR015880	58525	widely interspaced zinc finger motifs [Source:HGNC Symbol;Acc:HGNC:30917]	None	not tested	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000373933#ENSG00000011451#ENST00000389282#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000445824#ENSG00000011451#ENST00000545156#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000263381#ENSG00000011451#ENST00000263381#C2H2 ZF Containing Proteins#$#ENSP00000469138#ENSG00000011451#ENST00000596159#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
377	ENSG00000184937	WT1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Crystal structure (PDB:2JP9) is with dsDNA GCGCAGACGCCCCCGCG, which is consistent with the PWMs	IPR000976;IPR007087;IPR015880;IPR017987	7490	Wilms tumor 1 [Source:HGNC Symbol;Acc:HGNC:12796]	2JP9	DBD and Full	Yes	None	Crystal seems fine	a	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000184937#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000184937#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | NAS - PMID:7862533, PMID:83	$#ENSP00000331327#ENSG00000184937#ENST00000332351#C2H2 ZF Containing Proteins#WT1$#ENSP00000368370#ENSG00000184937#ENST00000379079#C2H2 ZF Containing Proteins#WT1$#ENSP00000415516#ENSG00000184937#ENST00000452863#C2H2 ZF Containing Proteins#WT1$#ENSP00000413452#ENSG00000184937#ENST00000448076#C2H2 ZF Containing Proteins#WT1$#ENSP00000435307#ENSG00000184937#ENST00000530998#C2H2 ZF Containing Proteins#WT1	FALSE
378	ENSG00000100811	YY1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880;IPR017114;	102466730	YY1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12856]	1UBD	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12584314;7501456;9141463;10452940;7565750;15316102;1655281;1720509	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000100811#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000100811#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1946405	$#ENSP00000262238#ENSG00000100811#ENST00000262238#C2H2 ZF Containing Proteins#$#ENSP00000452140#ENSG00000100811#ENST00000553625#C2H2 ZF Containing Proteins#$#ENSP00000451329#ENSG00000100811#ENST00000554371#C2H2 ZF Containing Proteins#$#ENSP00000452225#ENSG00000100811#ENST00000554804#C2H2 ZF Containing Proteins#	FALSE
379	ENSG00000230797	YY2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880;IPR017114;	404281	YY2 transcription factor [Source:HGNC Symbol;Acc:HGNC:31684]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000389381#ENSG00000230797#ENST00000429584#C2H2 ZF Containing Proteins#	FALSE
380	ENSG00000126804	ZBTB1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	22890	zinc finger and BTB domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20259]	None	Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000351587#ENSG00000126804#ENST00000358738#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000451000#ENSG00000126804#ENST00000554015#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000451584#ENSG00000126804#ENST00000553583#C2H2 ZF Containing Proteins#BTB	FALSE
381	ENSG00000205189	ZBTB10	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	65986	zinc finger and BTB domain containing 10 [Source:HGNC Symbol;Acc:HGNC:30953]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000368384#ENSG00000205189#ENST00000379091#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000412036#ENSG00000205189#ENST00000455036#C2H2 ZF Containing Proteins#BTB, DUF3342, zf-C2H2_4, zf-H2C2_2, zf-H2C2_5$#ENSP00000484716#ENSG00000205189#ENST00000610895#C2H2 ZF Containing Proteins#BTB, DUF3342	FALSE
382	ENSG00000066422	ZBTB11	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	27107	zinc finger and BTB domain containing 11 [Source:HGNC Symbol;Acc:HGNC:16740]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000066422#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000326200#ENSG00000066422#ENST00000312938#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000417369#ENSG00000066422#ENST00000461821#C2H2 ZF Containing Proteins#	FALSE
383	ENSG00000204366	ZBTB12	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	221527	zinc finger and BTB domain containing 12 [Source:HGNC Symbol;Acc:HGNC:19066]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000364677#ENSG00000204366#ENST00000375527#C2H2 ZF Containing Proteins#BTB	FALSE
384	ENSG00000198081	ZBTB14	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	7541	zinc finger and BTB domain containing 14 [Source:HGNC Symbol;Acc:HGNC:12860]	None	DBD and Full	Yes	None	Badis and Schmitges sboth use outdated symbol ZFP161	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8367294;10049742;14706637;15629158	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000198081#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17714511	$#ENSP00000349503#ENSG00000198081#ENST00000357006#C2H2 ZF Containing Proteins#BTB$#ENSP00000383009#ENSG00000198081#ENST00000400143#C2H2 ZF Containing Proteins#BTB$#ENSP00000463414#ENSG00000198081#ENST00000582135#C2H2 ZF Containing Proteins#BTB$#ENSP00000463555#ENSG00000198081#ENST00000582388#C2H2 ZF Containing Proteins#BTB$#ENSP00000484129#ENSG00000198081#ENST00000614697#C2H2 ZF Containing Proteins#BTB$#ENSP00000478971#ENSG00000198081#ENST00000615385#C2H2 ZF Containing Proteins#BTB	FALSE
385	ENSG00000109906	ZBTB16	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	7704	zinc finger and BTB domain containing 16 [Source:HGNC Symbol;Acc:HGNC:12930]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:12408802;12802276	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000109906#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:12802276	$#ENSP00000338157#ENSG00000109906#ENST00000335953#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-met$#ENSP00000376721#ENSG00000109906#ENST00000392996#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-met$#ENSP00000443013#ENSG00000109906#ENST00000535700#C2H2 ZF Containing Proteins#BTB$#ENSP00000437716#ENSG00000109906#ENST00000544220#C2H2 ZF Containing Proteins#BTB	FALSE
386	ENSG00000116809	ZBTB17	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	7709	zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936]	None	Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9312026	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000116809#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12244100	$#ENSP00000364885#ENSG00000116809#ENST00000375733#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000364895#ENSG00000116809#ENST00000375743#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000438529#ENSG00000116809#ENST00000537142#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000400827#ENSG00000116809#ENST00000440560#C2H2 ZF Containing Proteins#	FALSE
387	ENSG00000179456	ZBTB18	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	10472	zinc finger and BTB domain containing 18 [Source:HGNC Symbol;Acc:HGNC:13030]	None	DBD and Full	Yes	None	Cell2013 model has old symbol ZNF238	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000179456#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9756912, PMID:9770450	$#ENSP00000351539#ENSG00000179456#ENST00000358704#C2H2 ZF Containing Proteins#BTB$#ENSP00000481278#ENSG00000179456#ENST00000622512#C2H2 ZF Containing Proteins#BTB	FALSE
388	ENSG00000181472	ZBTB2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	57621	zinc finger and BTB domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20868]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000323183#ENSG00000181472#ENST00000325144#C2H2 ZF Containing Proteins#BTB	FALSE
389	ENSG00000181722	ZBTB20	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	26137	zinc finger and BTB domain containing 20 [Source:HGNC Symbol;Acc:HGNC:13503]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11744704	No	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000181722#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000349803#ENSG00000181722#ENST00000357258#C2H2 ZF Containing Proteins#BTB$#ENSP00000377375#ENSG00000181722#ENST00000393785#C2H2 ZF Containing Proteins#BTB$#ENSP00000420324#ENSG00000181722#ENST00000462705#C2H2 ZF Containing Proteins#BTB$#ENSP00000417307#ENSG00000181722#ENST00000464560#C2H2 ZF Containing Proteins#BTB$#ENSP00000419902#ENSG00000181722#ENST00000471418#C2H2 ZF Containing Proteins#BTB$#ENSP00000419153#ENSG00000181722#ENST00000474710#C2H2 ZF Containing Proteins#BTB$#ENSP00000418092#ENSG00000181722#ENST00000481632#C2H2 ZF Containing Proteins#BTB	FALSE
390	ENSG00000173276	ZBTB21	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	49854	zinc finger and BTB domain containing 21 [Source:HGNC Symbol;Acc:HGNC:13083]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000308759#ENSG00000173276#ENST00000310826#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000381510#ENSG00000173276#ENST00000398497#C2H2 ZF Containing Proteins#BTB$#ENSP00000381512#ENSG00000173276#ENST00000398499#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000381517#ENSG00000173276#ENST00000398505#C2H2 ZF Containing Proteins#BTB$#ENSP00000381523#ENSG00000173276#ENST00000398511#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000395186#ENSG00000173276#ENST00000449949#C2H2 ZF Containing Proteins#BTB$#ENSP00000387788#ENSG00000173276#ENST00000425521#C2H2 ZF Containing Proteins#BTB, DUF3342	FALSE
391	ENSG00000236104	ZBTB22	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	9278	zinc finger and BTB domain containing 22 [Source:HGNC Symbol;Acc:HGNC:13085]	None	DBD	not tested	None	There are five genes for this protein ENSG00000206280;ENSG00000227780;ENSG00000229253;ENSG00000236104;ENSG00000237056	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$##ENSG00000236104##C2H2 ZF Containing Proteins#	FALSE
392	ENSG00000089775	ZBTB25	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	7597	zinc finger and BTB domain containing 25 [Source:HGNC Symbol;Acc:HGNC:13112]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000089775#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2027750	$#ENSP00000450718#ENSG00000089775#ENST00000555220#C2H2 ZF Containing Proteins#BTB$#ENSP00000476746#ENSG00000089775#ENST00000608382#C2H2 ZF Containing Proteins#BTB$#ENSP00000378204#ENSG00000089775#ENST00000394715#C2H2 ZF Containing Proteins#BTB$#ENSP00000451046#ENSG00000089775#ENST00000555424#C2H2 ZF Containing Proteins#	FALSE
393	ENSG00000171448	ZBTB26	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	57684	zinc finger and BTB domain containing 26 [Source:HGNC Symbol;Acc:HGNC:23383]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000362760#ENSG00000171448#ENST00000373656#C2H2 ZF Containing Proteins#BTB$#ENSP00000362758#ENSG00000171448#ENST00000373654#C2H2 ZF Containing Proteins#BTB	FALSE
394	ENSG00000185670	ZBTB3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	79842	zinc finger and BTB domain containing 3 [Source:HGNC Symbol;Acc:HGNC:22918]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000378286#ENSG00000185670#ENST00000394807#C2H2 ZF Containing Proteins#BTB$#ENSP00000432731#ENSG00000185670#ENST00000527994#C2H2 ZF Containing Proteins#BTB	FALSE
395	ENSG00000011590	ZBTB32	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	27033	zinc finger and BTB domain containing 32 [Source:HGNC Symbol;Acc:HGNC:16763]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000262630#ENSG00000011590#ENST00000262630#C2H2 ZF Containing Proteins#BTB$#ENSP00000466524#ENSG00000011590#ENST00000426659#C2H2 ZF Containing Proteins#$#ENSP00000376035#ENSG00000011590#ENST00000392197#C2H2 ZF Containing Proteins#BTB	FALSE
396	ENSG00000177485	ZBTB33	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	10009	zinc finger and BTB domain containing 33 [Source:HGNC Symbol;Acc:HGNC:16682]	2LT7	DBD	not tested	None	Also known as Kaiso, crystal structure is nice	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11445535;14527417	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000314153#ENSG00000177485#ENST00000326624#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-H2C2_2$#ENSP00000450969#ENSG00000177485#ENST00000557385#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-H2C2_2	FALSE
397	ENSG00000177125	ZBTB34	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	403341	zinc finger and BTB domain containing 34 [Source:HGNC Symbol;Acc:HGNC:31446]	None	DBD	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	None	$#ENSP00000317534#ENSG00000177125#ENST00000319119#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000362551#ENSG00000177125#ENST00000373452#C2H2 ZF Containing Proteins#BTB, DUF3342	FALSE
398	ENSG00000185278	ZBTB37	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	84614	zinc finger and BTB domain containing 37 [Source:HGNC Symbol;Acc:HGNC:28365]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000356674#ENSG00000185278#ENST00000367701#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000356677#ENSG00000185278#ENST00000367704#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000356675#ENSG00000185278#ENST00000367702#C2H2 ZF Containing Proteins#BTB, DUF3342$#ENSP00000415293#ENSG00000185278#ENST00000427304#C2H2 ZF Containing Proteins#BTB, DUF3342	FALSE
399	ENSG00000177311	ZBTB38	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	It has a decent cassette of znfC2H2 domains and a BTB homodimerization domain. Requires CpG methylation for binding into a site in MYOG-promoter (PMID: 21625269).	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	253461	zinc finger and BTB domain containing 38 [Source:HGNC Symbol;Acc:HGNC:26636]	None	Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000177311#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000426931#ENSG00000177311#ENST00000509842#C2H2 ZF Containing Proteins#BTB$#ENSP00000424254#ENSG00000177311#ENST00000509883#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000422757#ENSG00000177311#ENST00000513570#C2H2 ZF Containing Proteins#BTB$#ENSP00000406955#ENSG00000177311#ENST00000441582#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000421037#ENSG00000177311#ENST00000507722#C2H2 ZF Containing Proteins#BTB$#ENSP00000425705#ENSG00000177311#ENST00000510338#C2H2 ZF Containing Proteins#BTB$#ENSP00000426387#ENSG00000177311#ENST00000514251#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000422347#ENSG00000177311#ENST00000504673#C2H2 ZF Containing Proteins#BTB$#ENSP00000422894#ENSG00000177311#ENST00000509813#C2H2 ZF Containing Proteins#BTB$#ENSP00000422081#ENSG00000177311#ENST00000510726#C2H2 ZF Containing Proteins#BTB$#ENSP00000372635#ENSG00000177311#ENST00000321464#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000490370#ENSG00000177311#ENST00000636289#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000490041#ENSG00000177311#ENST00000637056#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6	FALSE
400	ENSG00000166860	ZBTB39	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	9880	zinc finger and BTB domain containing 39 [Source:HGNC Symbol;Acc:HGNC:29014]	None	Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	Yes	None	$#ENSP00000300101#ENSG00000166860#ENST00000300101#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4	FALSE
401	ENSG00000174282	ZBTB4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	57659	zinc finger and BTB domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23847]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000174282#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16354688	$#ENSP00000307858#ENSG00000174282#ENST00000311403#C2H2 ZF Containing Proteins#BTB$#ENSP00000369973#ENSG00000174282#ENST00000380599#C2H2 ZF Containing Proteins#BTB	FALSE
402	ENSG00000184677	ZBTB40	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	9923	zinc finger and BTB domain containing 40 [Source:HGNC Symbol;Acc:HGNC:29045]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000363782#ENSG00000184677#ENST00000374651#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000364798#ENSG00000184677#ENST00000375647#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000383098#ENSG00000184677#ENST00000400239#C2H2 ZF Containing Proteins#BTB$#ENSP00000384527#ENSG00000184677#ENST00000404138#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4	FALSE
403	ENSG00000177888	ZBTB41	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	360023	zinc finger and BTB domain containing 41 [Source:HGNC Symbol;Acc:HGNC:24819]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000356375#ENSG00000177888#ENST00000367405#C2H2 ZF Containing Proteins#BTB	FALSE
404	ENSG00000179627	ZBTB42	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	100128927	zinc finger and BTB domain containing 42 [Source:HGNC Symbol;Acc:HGNC:32550]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000450673#ENSG00000179627#ENST00000555360#C2H2 ZF Containing Proteins#BTB$#ENSP00000409107#ENSG00000179627#ENST00000342537#C2H2 ZF Containing Proteins#BTB	FALSE
405	ENSG00000169155	ZBTB43	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	23099	zinc finger and BTB domain containing 43 [Source:HGNC Symbol;Acc:HGNC:17908]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000362563#ENSG00000169155#ENST00000373464#C2H2 ZF Containing Proteins#BTB$#ENSP00000390344#ENSG00000169155#ENST00000449886#C2H2 ZF Containing Proteins#BTB$#ENSP00000412145#ENSG00000169155#ENST00000450858#C2H2 ZF Containing Proteins#BTB$#ENSP00000362556#ENSG00000169155#ENST00000373457#C2H2 ZF Containing Proteins#BTB	FALSE
406	ENSG00000196323	ZBTB44	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	29068	Zinc finger and BTB domain containing 44 [Source:HGNC Symbol;Acc:HGNC:25001]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000350574#ENSG00000196323#ENST00000357899#C2H2 ZF Containing Proteins#BTB$#ENSP00000433457#ENSG00000196323#ENST00000525842#C2H2 ZF Containing Proteins#BTB$#ENSP00000434177#ENSG00000196323#ENST00000530205#C2H2 ZF Containing Proteins#BTB$#ENSP00000432558#ENSG00000196323#ENST00000529982#C2H2 ZF Containing Proteins#	FALSE
407	ENSG00000119574	ZBTB45	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	84878	zinc finger and BTB domain containing 45 [Source:HGNC Symbol;Acc:HGNC:23715]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	None	$#ENSP00000346603#ENSG00000119574#ENST00000354590#C2H2 ZF Containing Proteins#BTB$#ENSP00000469089#ENSG00000119574#ENST00000594051#C2H2 ZF Containing Proteins#BTB$#ENSP00000470316#ENSG00000119574#ENST00000600130#C2H2 ZF Containing Proteins#BTB$#ENSP00000471885#ENSG00000119574#ENST00000596739#C2H2 ZF Containing Proteins#	FALSE
408	ENSG00000130584	ZBTB46	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Specificity is unknown; functions in dendritic cells (PMID: 22615130).	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	140685	zinc finger and BTB domain containing 46 [Source:HGNC Symbol;Acc:HGNC:16094]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000303102#ENSG00000130584#ENST00000302995#C2H2 ZF Containing Proteins#BTB, BTB_3, DUF3342$#ENSP00000378536#ENSG00000130584#ENST00000395104#C2H2 ZF Containing Proteins#BTB, BTB_3, DUF3342$#ENSP00000245663#ENSG00000130584#ENST00000245663#C2H2 ZF Containing Proteins#BTB, BTB_3, DUF3342	FALSE
409	ENSG00000114853	ZBTB47	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	92999	zinc finger and BTB domain containing 47 [Source:HGNC Symbol;Acc:HGNC:26955]	None	Full	not tested	None	None	b	Yes	No	No	1a2, Orthologous HQ evidence	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000232974#ENSG00000114853#ENST00000232974#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_6$#ENSP00000420968#ENSG00000114853#ENST00000505904#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6	FALSE
410	ENSG00000204859	ZBTB48	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	3104	zinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000204859#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8661141	$#ENSP00000366902#ENSG00000204859#ENST00000377674#C2H2 ZF Containing Proteins#BTB$#ENSP00000313416#ENSG00000204859#ENST00000319084#C2H2 ZF Containing Proteins#BTB$#ENSP00000466390#ENSG00000204859#ENST00000488936#C2H2 ZF Containing Proteins#$#ENSP00000416054#ENSG00000204859#ENST00000435905#C2H2 ZF Containing Proteins#BTB	FALSE
411	ENSG00000168826	ZBTB49	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;IPR020542	166793	zinc finger and BTB domain containing 49 [Source:HGNC Symbol;Acc:HGNC:19883]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000338807#ENSG00000168826#ENST00000337872#C2H2 ZF Containing Proteins#BTB$#ENSP00000421654#ENSG00000168826#ENST00000504302#C2H2 ZF Containing Proteins#$#ENSP00000425747#ENSG00000168826#ENST00000502918#C2H2 ZF Containing Proteins#BTB	FALSE
412	ENSG00000168795	ZBTB5	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Binds to GATCGGGCGGGGCGGTTGTATATCA; GATCCGTTAGAGGAAGAAGACTGGGCATGTCTG and GATCCATCAGGAACATGTCCCAACATGTTGAGCTC based on EMSA using recombinant protein (PMID: 19491398).	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	9925	zinc finger and BTB domain containing 5 [Source:HGNC Symbol;Acc:HGNC:23836]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000307604#ENSG00000168795#ENST00000307750#C2H2 ZF Containing Proteins#BTB, DUF3342, zf-C2H2_4, zf-H2C2_2	FALSE
413	ENSG00000186130	ZBTB6	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	10773	zinc finger and BTB domain containing 6 [Source:HGNC Symbol;Acc:HGNC:16764]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000362763#ENSG00000186130#ENST00000373659#C2H2 ZF Containing Proteins#BTB	FALSE
414	ENSG00000178951	ZBTB7A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	51341	zinc finger and BTB domain containing 7A [Source:HGNC Symbol;Acc:HGNC:18078]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000178951#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000323670#ENSG00000178951#ENST00000322357#C2H2 ZF Containing Proteins#BTB$#ENSP00000471865#ENSG00000178951#ENST00000601588#C2H2 ZF Containing Proteins#BTB	FALSE
415	ENSG00000160685	ZBTB7B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	51043	zinc finger and BTB domain containing 7B [Source:HGNC Symbol;Acc:HGNC:18668]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7937772	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000292176#ENSG00000160685#ENST00000292176#C2H2 ZF Containing Proteins#BTB$#ENSP00000357411#ENSG00000160685#ENST00000368426#C2H2 ZF Containing Proteins#BTB$#ENSP00000406286#ENSG00000160685#ENST00000417934#C2H2 ZF Containing Proteins#BTB$#ENSP00000438647#ENSG00000160685#ENST00000535420#C2H2 ZF Containing Proteins#BTB	FALSE
416	ENSG00000184828	ZBTB7C	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;IPR016024	201501	zinc finger and BTB domain containing 7C [Source:HGNC Symbol;Acc:HGNC:31700]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000439781#ENSG00000184828#ENST00000535628#C2H2 ZF Containing Proteins#BTB$#ENSP00000464724#ENSG00000184828#ENST00000585404#C2H2 ZF Containing Proteins#$#ENSP00000466944#ENSG00000184828#ENST00000586047#C2H2 ZF Containing Proteins#$#ENSP00000468254#ENSG00000184828#ENST00000586438#C2H2 ZF Containing Proteins#BTB$#ENSP00000468537#ENSG00000184828#ENST00000586525#C2H2 ZF Containing Proteins#$#ENSP00000466006#ENSG00000184828#ENST00000586743#C2H2 ZF Containing Proteins#$#ENSP00000465760#ENSG00000184828#ENST00000587107#C2H2 ZF Containing Proteins#$#ENSP00000468152#ENSG00000184828#ENST00000588028#C2H2 ZF Containing Proteins#$#ENSP00000466088#ENSG00000184828#ENST00000588053#C2H2 ZF Containing Proteins#$#ENSP00000468814#ENSG00000184828#ENST00000588149#C2H2 ZF Containing Proteins#$#ENSP00000467456#ENSG00000184828#ENST00000588566#C2H2 ZF Containing Proteins#$#ENSP00000468502#ENSG00000184828#ENST00000588970#C2H2 ZF Containing Proteins#$#ENSP00000468782#ENSG00000184828#ENST00000588982#C2H2 ZF Containing Proteins#BTB$#ENSP00000467147#ENSG00000184828#ENST00000589077#C2H2 ZF Containing Proteins#$#ENSP00000467338#ENSG00000184828#ENST00000589170#C2H2 ZF Containing Proteins#$#ENSP00000468019#ENSG00000184828#ENST00000589194#C2H2 ZF Containing Proteins#$#ENSP00000465160#ENSG00000184828#ENST00000590178#C2H2 ZF Containing Proteins#$#ENSP00000465494#ENSG00000184828#ENST00000590374#C2H2 ZF Containing Proteins#$#ENSP00000467323#ENSG00000184828#ENST00000590437#C2H2 ZF Containing Proteins#BTB$#ENSP00000467877#ENSG00000184828#ENST00000590800#C2H2 ZF Containing Proteins#BTB$#ENSP00000468306#ENSG00000184828#ENST00000590855#C2H2 ZF Containing Proteins#$#ENSP00000465265#ENSG00000184828#ENST00000591279#C2H2 ZF Containing Proteins#$#ENSP00000467758#ENSG00000184828#ENST00000591405#C2H2 ZF Containing Proteins#$#ENSP00000468752#ENSG00000184828#ENST00000591526#C2H2 ZF Containing Proteins#$#ENSP00000465835#ENSG00000184828#ENST00000592387#C2H2 ZF Containing Proteins#$#ENSP00000468087#ENSG00000184828#ENST00000592656#C2H2 ZF Containing Proteins#$#ENSP00000465832#ENSG00000184828#ENST00000593159#C2H2 ZF Containing Proteins#	FALSE
417	ENSG00000160062	ZBTB8A	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a two znfC2H2 domains and a BTB-domain	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	653121	zinc finger and BTB domain containing 8A [Source:HGNC Symbol;Acc:HGNC:24172]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000317561#ENSG00000160062#ENST00000316459#C2H2 ZF Containing Proteins#BTB, BTB_2, DUF3342$#ENSP00000362609#ENSG00000160062#ENST00000373510#C2H2 ZF Containing Proteins#BTB, BTB_2, DUF3342	FALSE
418	ENSG00000273274	ZBTB8B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a BTB homodimerization domain	IPR007087;IPR000210;IPR015880;	728116	zinc finger and BTB domain containing 8B [Source:HGNC Symbol;Acc:HGNC:37057]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000476499#ENSG00000273274#ENST00000609129#C2H2 ZF Containing Proteins#BTB, DUF3342, Ribosomal_60s	FALSE
419	ENSG00000213588	ZBTB9	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has two znfC2H2 domains and a BTB-domain that typically mediates homotypic dimerization	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	221504	zinc finger and BTB domain containing 9 [Source:HGNC Symbol;Acc:HGNC:28323]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000378503#ENSG00000213588#ENST00000395064#C2H2 ZF Containing Proteins#BTB$#ENSP00000478118#ENSG00000213588#ENST00000612407#C2H2 ZF Containing Proteins#$#ENSP00000484571#ENSG00000213588#ENST00000612775#C2H2 ZF Containing Proteins#BTB$#ENSP00000484265#ENSG00000213588#ENST00000621915#C2H2 ZF Containing Proteins#BTB	FALSE
420	ENSG00000066827	ZFAT	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	IPR007087;IPR015880	57623	zinc finger and AT-hook domain containing [Source:HGNC Symbol;Acc:HGNC:19899]	None	DBD	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000066827#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066827#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000367069#ENSG00000066827#ENST00000377838#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000394501#ENSG00000066827#ENST00000429442#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000428483#ENSG00000066827#ENST00000520214#C2H2 ZF Containing Proteins#zf-Di19$#ENSP00000427879#ENSG00000066827#ENST00000520356#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000427831#ENSG00000066827#ENST00000520727#C2H2 ZF Containing Proteins#zf-Di19$#ENSP00000429091#ENSG00000066827#ENST00000523399#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5$#ENSP00000429600#ENSG00000066827#ENST00000521673#C2H2 ZF Containing Proteins#	FALSE
421	ENSG00000184517	ZFP1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	162239	ZFP1 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:23328]	None	DBD	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000184517#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000333192#ENSG00000184517#ENST00000332307#C2H2 ZF Containing Proteins#KRAB$#ENSP00000377080#ENSG00000184517#ENST00000393430#C2H2 ZF Containing Proteins#KRAB$#ENSP00000457941#ENSG00000184517#ENST00000464850#C2H2 ZF Containing Proteins#KRAB$#ENSP00000454286#ENSG00000184517#ENST00000568079#C2H2 ZF Containing Proteins#$#ENSP00000457044#ENSG00000184517#ENST00000570010#C2H2 ZF Containing Proteins#KRAB	TRUE
422	ENSG00000142065	ZFP14	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	57677	ZFP14 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:29312]	None	Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000142065#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000270001#ENSG00000142065#ENST00000270001#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466416#ENSG00000142065#ENST00000589280#C2H2 ZF Containing Proteins#KRAB	TRUE
423	ENSG00000198939	ZFP2	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	80108	ZFP2 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:26138]	None	Full	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000198939#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000354453#ENSG00000198939#ENST00000361362#C2H2 ZF Containing Proteins#$#ENSP00000430531#ENSG00000198939#ENST00000523286#C2H2 ZF Containing Proteins#$#ENSP00000429095#ENSG00000198939#ENST00000520660#C2H2 ZF Containing Proteins#$#ENSP00000431074#ENSG00000198939#ENST00000520805#C2H2 ZF Containing Proteins#	FALSE
424	ENSG00000196867	ZFP28	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE); Has a putative AT-hook	None	IPR001909;IPR007087;IPR015880;	140612	ZFP28 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:17801]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000196867#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000301318#ENSG00000196867#ENST00000301318#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468603#ENSG00000196867#ENST00000591844#C2H2 ZF Containing Proteins#KRAB	TRUE
425	ENSG00000180787	ZFP3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	124961	ZFP3 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12861]	None	Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000180787#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000320347#ENSG00000180787#ENST00000318833#C2H2 ZF Containing Proteins#	FALSE
426	ENSG00000120784	ZFP30	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	22835	ZFP30 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:29555]	None	DBD	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000120784#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000343581#ENSG00000120784#ENST00000351218#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000422930#ENSG00000120784#ENST00000514101#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000466563#ENSG00000120784#ENST00000587809#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465496#ENSG00000120784#ENST00000588979#C2H2 ZF Containing Proteins#KRAB	TRUE
427	ENSG00000136866	ZFP37	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7539	ZFP37 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12863]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	$#ENSG00000136866#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9585434	$#ENSP00000363344#ENSG00000136866#ENST00000374227#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000451310#ENSG00000136866#ENST00000555206#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000452552#ENSG00000136866#ENST00000553380#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4	TRUE
428	ENSG00000181638	ZFP41	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	286128	ZFP41 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:26786]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000430465#ENSG00000181638#ENST00000520584#C2H2 ZF Containing Proteins#$#ENSP00000327427#ENSG00000181638#ENST00000330701#C2H2 ZF Containing Proteins#	FALSE
429	ENSG00000179059	ZFP42	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	132625	ZFP42 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:30949]	None	DBD and Full	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000179059#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:14688391	$#ENSP00000317686#ENSG00000179059#ENST00000326866#C2H2 ZF Containing Proteins#$#ENSP00000424662#ENSG00000179059#ENST00000509524#C2H2 ZF Containing Proteins#$#ENSP00000483363#ENSG00000179059#ENST00000618147#C2H2 ZF Containing Proteins#	FALSE
430	ENSG00000204644	ZFP57	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	Recognizes CpG methylated  ACTGCGGCAAT site based on structure 4GZN	IPR001909;IPR007087;IPR015880;	346171	ZFP57 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:18791]	4GZN	not tested	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000418259#ENSG00000204644#ENST00000488757#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366078#ENSG00000204644#ENST00000376881#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366080#ENSG00000204644#ENST00000376883#C2H2 ZF Containing Proteins#KRAB	TRUE
431	ENSG00000196670	ZFP62	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	643836	ZFP62 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:23241]	None	DBD	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000423820#ENSG00000196670#ENST00000502412#C2H2 ZF Containing Proteins#$#ENSP00000422987#ENSG00000196670#ENST00000504225#C2H2 ZF Containing Proteins#$#ENSP00000426193#ENSG00000196670#ENST00000512132#C2H2 ZF Containing Proteins#	FALSE
432	ENSG00000020256	ZFP64	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR007087;IPR015880	55734	ZFP64 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:15940]	None	DBD and Full	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:9034307;	No	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	None	$#ENSP00000216923#ENSG00000020256#ENST00000216923#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000355179#ENSG00000020256#ENST00000361387#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000360570#ENSG00000020256#ENST00000371515#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000360573#ENSG00000020256#ENST00000371518#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000344615#ENSG00000020256#ENST00000346617#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000360578#ENSG00000020256#ENST00000371523#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000379303#ENSG00000020256#ENST00000395979#C2H2 ZF Containing Proteins#$#ENSP00000403424#ENSG00000020256#ENST00000456175#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_5	FALSE
433	ENSG00000187815	ZFP69	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	339559	ZFP69 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:24708]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000361791#ENSG00000187815#ENST00000372706#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000361790#ENSG00000187815#ENST00000372705#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
434	ENSG00000187801	ZFP69B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	65243	ZFP69 zinc finger protein B [Source:HGNC Symbol;Acc:HGNC:28053]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000187801#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000354547#ENSG00000187801#ENST00000361584#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000435907#ENSG00000187801#ENST00000484445#C2H2 ZF Containing Proteins#SCAN$#ENSP00000399664#ENSG00000187801#ENST00000411995#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
435	ENSG00000181007	ZFP82	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284406	ZFP82 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:28682]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000181007#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000431265#ENSG00000181007#ENST00000392161#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6$#ENSP00000468212#ENSG00000181007#ENST00000445543#C2H2 ZF Containing Proteins#	TRUE
436	ENSG00000184939	ZFP90	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	146198	ZFP90 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:23329]	None	Full	not tested	None	None	x	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7576184;11501753	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000184939#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000454418#ENSG00000184939#ENST00000563169#C2H2 ZF Containing Proteins#KRAB$#ENSP00000460547#ENSG00000184939#ENST00000570495#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480309#ENSG00000184939#ENST00000611381#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458410#ENSG00000184939#ENST00000573113#C2H2 ZF Containing Proteins#KRAB$#ENSP00000459846#ENSG00000184939#ENST00000573161#C2H2 ZF Containing Proteins#	TRUE
437	ENSG00000186660	ZFP91	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Possible false positive. An Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK; leading to stabilization and activation of MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway (PMID: 20682767).	IPR007087;IPR015880	80829	ZFP91 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:14983]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000339030#ENSG00000186660#ENST00000316059#C2H2 ZF Containing Proteins#	FALSE
438	ENSG00000189420	ZFP92	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	139735	ZFP92 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12865]	None	not tested	not tested	None	None	c	Yes	No	No	2a2, orthologous lower confidence evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000462054#ENSG00000189420#ENST00000338647#C2H2 ZF Containing Proteins#KRAB	TRUE
439	ENSG00000162300	ZFPL1	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a Golgi apparatus integral membrane protein with RING-type zinc fingers (PMID:18323775 ).	None	None	Zinc finger protein like 1	None	not tested	not tested	None	Protein is a Golgi apparatus integral membrane protein with RING-type zinc fingers (PMID:18323775 ).	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
440	ENSG00000179588	ZFPM1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	161882	zinc finger protein, FOG family member 1 [Source:HGNC Symbol;Acc:HGNC:19762]	None	not tested	not tested	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:9230307	Yes	3a, decent circumstantial evidence for its role as	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000179588#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15920471	$#ENSP00000326630#ENSG00000179588#ENST00000319555#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_jaz, zf-met$#ENSP00000480412#ENSG00000179588#ENST00000562437#C2H2 ZF Containing Proteins#$#ENSP00000484216#ENSG00000179588#ENST00000563351#C2H2 ZF Containing Proteins#$#ENSP00000482796#ENSG00000179588#ENST00000569086#C2H2 ZF Containing Proteins#	FALSE
441	ENSG00000169946	ZFPM2	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	FOG-proteins use some of their zinc-fingers to interact with the GATA proteins.  Other C2H2 ZFs are probably also capable of binding DNA (PMID: 10329627).	IPR007087;IPR015880	23414	zinc finger protein, FOG family member 2 [Source:HGNC Symbol;Acc:HGNC:16700]	None	Full	not tested	None	None	a	Yes	TF Gene Candidate__Co-activation_PMIDS:9927675;10330188;10438528	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000169946#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000384179#ENSG00000169946#ENST00000407775#C2H2 ZF Containing Proteins#$#ENSP00000428720#ENSG00000169946#ENST00000517361#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000430757#ENSG00000169946#ENST00000520492#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000428149#ENSG00000169946#ENST00000520027#C2H2 ZF Containing Proteins#	FALSE
442	ENSG00000056097	ZFR	C2H2 ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR003604;IPR006561;IPR007087;IPR015880	51663	zinc finger RNA binding protein [Source:HGNC Symbol;Acc:HGNC:17277]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000265069#ENSG00000056097#ENST00000265069#C2H2 ZF Containing Proteins#DZF, zf-C2H2_2, zf-C2H2_jaz, zf-met	FALSE
443	ENSG00000105278	ZFR2	C2H2 ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	ZFR2 contains only RNA-binding zinc fingers	IPR003604;IPR006561;IPR007087;IPR015880	23217	zinc finger RNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:29189]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000388567#ENSG00000105278#ENST00000439086#C2H2 ZF Containing Proteins#$#ENSP00000467762#ENSG00000105278#ENST00000591712#C2H2 ZF Containing Proteins#$#ENSP00000262961#ENSG00000105278#ENST00000262961#C2H2 ZF Containing Proteins#DZF, zf-C2H2_2, zf-C2H2_jaz, zf-met$#ENSP00000468289#ENSG00000105278#ENST00000592398#C2H2 ZF Containing Proteins#	FALSE
444	ENSG00000005889	ZFX	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR006794;IPR007087;IPR015880;	7543	zinc finger protein, X-linked [Source:HGNC Symbol;Acc:HGNC:12869]	None	DBD	Yes	None	There is a ChIP-seq experiment that has yielded decent looking motif with CGCNNGGCCGCG-consensus PMID:18555785	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000005889#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000368475#ENSG00000005889#ENST00000379177#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000438233#ENSG00000005889#ENST00000539115#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000416298#ENSG00000005889#ENST00000419690#C2H2 ZF Containing Proteins#$#ENSP00000411637#ENSG00000005889#ENST00000428571#C2H2 ZF Containing Proteins#Zfx_Zfy_act	FALSE
445	ENSG00000067646	ZFY	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR006794;IPR007087;IPR015880;	7544	zinc finger protein, Y-linked [Source:HGNC Symbol;Acc:HGNC:12870]	None	Full	not tested	None	None	a	Yes	No	Yes	1a2, Orthologous HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000067646#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000155093#ENSG00000067646#ENST00000155093#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000393908#ENSG00000067646#ENST00000449237#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000485605#ENSG00000067646#ENST00000625061#C2H2 ZF Containing Proteins#Zfx_Zfy_act$#ENSP00000388814#ENSG00000067646#ENST00000443793#C2H2 ZF Containing Proteins#	FALSE
446	ENSG00000152977	ZIC1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7545	Zic family member 1 [Source:HGNC Symbol;Acc:HGNC:12872]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11038359	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000152977#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000152977#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | TAS - PMID:8542595	$#ENSP00000282928#ENSG00000152977#ENST00000282928#C2H2 ZF Containing Proteins#$#ENSP00000419664#ENSG00000152977#ENST00000488404#C2H2 ZF Containing Proteins#	FALSE
447	ENSG00000043355	ZIC2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR007087;IPR015880	7546	Zic family member 2 [Source:HGNC Symbol;Acc:HGNC:12873]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11053430	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000043355#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000043355#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000365514#ENSG00000043355#ENST00000376335#C2H2 ZF Containing Proteins#	FALSE
448	ENSG00000156925	ZIC3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7547	Zic family member 3 [Source:HGNC Symbol;Acc:HGNC:12874]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11053430	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000156925#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17764085$#ENSG00000156925#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17764085	$#ENSP00000287538#ENSG00000156925#ENST00000287538#C2H2 ZF Containing Proteins#$#ENSP00000359638#ENSG00000156925#ENST00000370606#C2H2 ZF Containing Proteins#	FALSE
449	ENSG00000174963	ZIC4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	84107	Zic family member 4 [Source:HGNC Symbol;Acc:HGNC:20393]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:15338008;15465018	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000372553#ENSG00000174963#ENST00000383075#C2H2 ZF Containing Proteins#$#ENSP00000420627#ENSG00000174963#ENST00000462748#C2H2 ZF Containing Proteins#$#ENSP00000397695#ENSG00000174963#ENST00000425731#C2H2 ZF Containing Proteins#$#ENSP00000420775#ENSG00000174963#ENST00000473123#C2H2 ZF Containing Proteins#$#ENSP00000417855#ENSG00000174963#ENST00000484399#C2H2 ZF Containing Proteins#$#ENSP00000435509#ENSG00000174963#ENST00000525172#C2H2 ZF Containing Proteins#	FALSE
450	ENSG00000139800	ZIC5	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	85416	Zic family member 5 [Source:HGNC Symbol;Acc:HGNC:20322]	None	DBD	Yes	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15465018;15136147;15465018	No	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000267294#ENSG00000139800#ENST00000267294#C2H2 ZF Containing Proteins#	FALSE
451	ENSG00000171649	ZIK1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284307	zinc finger protein interacting with K protein 1 [Source:HGNC Symbol;Acc:HGNC:33104]	None	Full	not tested	None	None	b	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:8910362	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000171649#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000303820#ENSG00000171649#ENST00000307468#C2H2 ZF Containing Proteins#$#ENSP00000472867#ENSG00000171649#ENST00000597850#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468937#ENSG00000171649#ENST00000599456#C2H2 ZF Containing Proteins#$#ENSP00000438487#ENSG00000171649#ENST00000536878#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472088#ENSG00000171649#ENST00000600053#C2H2 ZF Containing Proteins#KRAB	TRUE
452	ENSG00000269699	ZIM2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	Binds GKGGSWST consensus with GTGGCAGT as the optimal site based on competition EMSA (PMID: 26692216).	IPR001909;IPR007087;IPR015880;	23619	zinc finger imprinted 2 [Source:HGNC Symbol;Acc:HGNC:12875]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000269699#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000472306#ENSG00000269699#ENST00000593711#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470326#ENSG00000269699#ENST00000601070#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469173#ENSG00000269699#ENST00000593931#C2H2 ZF Containing Proteins#	TRUE
453	ENSG00000141946	ZIM3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	114026	zinc finger imprinted 3 [Source:HGNC Symbol;Acc:HGNC:16366]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000141946#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000269834#ENSG00000141946#ENST00000269834#C2H2 ZF Containing Proteins#KRAB	TRUE
454	ENSG00000106261	ZKSCAN1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7586	zinc finger with KRAB and SCAN domains 1 [Source:HGNC Symbol;Acc:HGNC:13101]	None	Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000106261#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:7557990	$#ENSP00000323148#ENSG00000106261#ENST00000324306#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000409172#ENSG00000106261#ENST00000426572#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000443508#ENSG00000106261#ENST00000535170#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394445#ENSG00000106261#ENST00000432317#C2H2 ZF Containing Proteins#SCAN	TRUE
455	ENSG00000155592	ZKSCAN2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	342357	zinc finger with KRAB and SCAN domains 2 [Source:HGNC Symbol;Acc:HGNC:25677]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000155592#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000331626#ENSG00000155592#ENST00000328086#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
456	ENSG00000189298	ZKSCAN3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	80317	zinc finger with KRAB and SCAN domains 3 [Source:HGNC Symbol;Acc:HGNC:13853]	None	Full	not tested	None	The Cell paper has this under heretic symbol ZNF306	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000189298#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18940803$#ENSG00000189298#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:23434374	$#ENSP00000252211#ENSG00000189298#ENST00000252211#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000366465#ENSG00000189298#ENST00000377255#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000341883#ENSG00000189298#ENST00000341464#C2H2 ZF Containing Proteins#KRAB	TRUE
457	ENSG00000187626	ZKSCAN4	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	387032	zinc finger with KRAB and SCAN domains 4 [Source:HGNC Symbol;Acc:HGNC:13854]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000187626#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366509#ENSG00000187626#ENST00000377294#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
458	ENSG00000196652	ZKSCAN5	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	23660	zinc finger with KRAB and SCAN domains 5 [Source:HGNC Symbol;Acc:HGNC:12867]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000196652#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:10585779	$#ENSP00000322872#ENSG00000196652#ENST00000326775#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000377725#ENSG00000196652#ENST00000394170#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000392104#ENSG00000196652#ENST00000451158#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
459	ENSG00000196345	ZKSCAN7	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	55888	zinc finger with KRAB and SCAN domains 7 [Source:HGNC Symbol;Acc:HGNC:12955]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000196345#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000273320#ENSG00000196345#ENST00000273320#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000345404#ENSG00000196345#ENST00000341840#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000416681#ENSG00000196345#ENST00000431636#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000405034#ENSG00000196345#ENST00000447279#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389243#ENSG00000196345#ENST00000419137#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395524#ENSG00000196345#ENST00000426540#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
460	ENSG00000198315	ZKSCAN8	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7745	zinc finger with KRAB and SCAN domains 8 [Source:HGNC Symbol;Acc:HGNC:12983]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000198315#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000332750#ENSG00000198315#ENST00000330236#C2H2 ZF Containing Proteins#KRAB, SCAN, SPX$#ENSP00000402948#ENSG00000198315#ENST00000457389#C2H2 ZF Containing Proteins#KRAB, SCAN, SPX	TRUE
461	ENSG00000166432	ZMAT1	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Possible RBP.	IPR003604;IPR007087;IPR015880;	84460	Zinc finger matrin-type 1 [Source:HGNC Symbol;Acc:HGNC:29377]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000361868#ENSG00000166432#ENST00000372782#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000437529#ENSG00000166432#ENST00000540921#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met	FALSE
462	ENSG00000172667	ZMAT3	C2H2 ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein binds RNA (PMID: 19805223 and PMID: 16844115).	IPR003604;IPR015880;IPR022755;	64393	zinc finger matrin-type 3 [Source:HGNC Symbol;Acc:HGNC:29983]	None	DBD and Full	not tested	None	None	b	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000311221#ENSG00000172667#ENST00000311417#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, $#ENSP00000396506#ENSG00000172667#ENST00000432729#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, $#ENSP00000398920#ENSG00000172667#ENST00000414084#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met	FALSE
463	ENSG00000165061	ZMAT4	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Possible RBP.	IPR003604;IPR007087;IPR015880;IPR022755	79698	zinc finger matrin-type 4 [Source:HGNC Symbol;Acc:HGNC:25844]	None	not tested	Yes	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000319785#ENSG00000165061#ENST00000315769#C2H2 ZF Containing Proteins#CTU2, DUF3449, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, $#ENSP00000297737#ENSG00000165061#ENST00000297737#C2H2 ZF Containing Proteins#DUF3449, zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1,$#ENSP00000428423#ENSG00000165061#ENST00000519406#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met	FALSE
464	ENSG00000256223	ZNF10	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7556	zinc finger protein 268 [Source:HGNC Symbol;Acc:HGNC:13061]	None	DBD and Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000248211#ENSG00000256223#ENST00000248211#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000384893#ENSG00000256223#ENST00000402932#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393814#ENSG00000256223#ENST00000426665#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000445997#ENSG00000256223#ENST00000538918#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438232#ENSG00000256223#ENST00000540609#C2H2 ZF Containing Proteins#KRAB	TRUE
465	ENSG00000197020	ZNF100	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	163227	zinc finger protein 100 [Source:HGNC Symbol;Acc:HGNC:12880]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000445201#ENSG00000197020#ENST00000305570#C2H2 ZF Containing Proteins#$#ENSP00000351042#ENSG00000197020#ENST00000358296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471371#ENSG00000197020#ENST00000594401#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471057#ENSG00000197020#ENST00000598026#C2H2 ZF Containing Proteins#KRAB	TRUE
466	ENSG00000181896	ZNF101	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	94039	zinc finger protein 101 [Source:HGNC Symbol;Acc:HGNC:12881]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	None	$#ENSP00000400952#ENSG00000181896#ENST00000415784#C2H2 ZF Containing Proteins#$#ENSP00000466697#ENSG00000181896#ENST00000444249#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468049#ENSG00000181896#ENST00000592502#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467112#ENSG00000181896#ENST00000541458#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
467	ENSG00000103994	ZNF106	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	C2H2 ZFs are not present in most isoforms; of which most contain WD40 repeats. Previous annotations (TFCat) suggest role as a cofactor (PMID: 15833274).	IPR001680;IPR007087;IPR015880;IPR017986	64397	zinc finger protein 106 [Source:HGNC Symbol;Acc:HGNC:12886]	None	not tested	not tested	None	None	c	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15833274	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000263805#ENSG00000103994#ENST00000263805#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, WD40, WD40_like, zf-C2H2_ab$#ENSP00000456845#ENSG00000103994#ENST00000564754#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz$#ENSP00000455674#ENSG00000103994#ENST00000565380#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, PQQ_3, WD40, WD40_like, zf-$#ENSP00000456604#ENSG00000103994#ENST00000565500#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, Nup160, PQQ_3, WD40, WD40_l$#ENSP00000457637#ENSG00000103994#ENST00000565611#C2H2 ZF Containing Proteins#ANAPC4_WD40, BBS2_Mid, Nup160, PQQ_3, WD40, WD40_l$#ENSP00000455049#ENSG00000103994#ENST00000565948#C2H2 ZF Containing Proteins#$#ENSP00000456191#ENSG00000103994#ENST00000569648#C2H2 ZF Containing Proteins#ANAPC4_WD40, PQQ, PQQ_3, Urease_beta, WD40, WD40_l	FALSE
468	ENSG00000196247	ZNF107	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	51427	zinc finger protein 107 [Source:HGNC Symbol;Acc:HGNC:12887]	None	Full	not tested	None	None	b	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000343443#ENSG00000196247#ENST00000344930#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000353234#ENSG00000196247#ENST00000360117#C2H2 ZF Containing Proteins#$#ENSP00000378789#ENSG00000196247#ENST00000395391#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000483720#ENSG00000196247#ENST00000620827#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	FALSE
469	ENSG00000062370	ZNF112	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of znfC2H2 domains and a KRAB-domain; virtually nothing is known about it.	IPR001909;IPR007087;IPR015880;	7771	zinc finger protein 112 [Source:HGNC Symbol;Acc:HGNC:12892]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000062370#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000337081#ENSG00000062370#ENST00000337401#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000346305#ENSG00000062370#ENST00000354340#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467994#ENSG00000062370#ENST00000588057#C2H2 ZF Containing Proteins#KRAB	TRUE
470	ENSG00000178150	ZNF114	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	163071	zinc finger protein 114 [Source:HGNC Symbol;Acc:HGNC:12894]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000318898#ENSG00000178150#ENST00000315849#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469998#ENSG00000178150#ENST00000595607#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471469#ENSG00000178150#ENST00000595408#C2H2 ZF Containing Proteins#KRAB	TRUE
471	ENSG00000152926	ZNF117	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	51351	zinc finger protein 117 [Source:HGNC Symbol;Acc:HGNC:12897]	None	not tested	not tested	None	None	b	Yes	No	Yes	2a2, orthologous lower confidence evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000152926#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:2023909	$#ENSP00000282869#ENSG00000152926#ENST00000282869#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000479944#ENSG00000152926#ENST00000620222#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000484825#ENSG00000152926#ENST00000610793#C2H2 ZF Containing Proteins#XPA_N	FALSE
472	ENSG00000164631	ZNF12	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	7559	zinc finger protein 12 [Source:HGNC Symbol;Acc:HGNC:12902]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	No	$#ENSG00000164631#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000384405#ENSG00000164631#ENST00000404360#C2H2 ZF Containing Proteins#$#ENSP00000385939#ENSG00000164631#ENST00000405858#C2H2 ZF Containing Proteins#KRAB$#ENSP00000344745#ENSG00000164631#ENST00000342651#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378375#ENSG00000164631#ENST00000394917#C2H2 ZF Containing Proteins#KRAB	TRUE
473	ENSG00000197961	ZNF121	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	7675	zinc finger protein 121 [Source:HGNC Symbol;Acc:HGNC:12904]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000197961#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000468643#ENSG00000197961#ENST00000586602#C2H2 ZF Containing Proteins#$#ENSP00000326967#ENSG00000197961#ENST00000320451#C2H2 ZF Containing Proteins#$#ENSP00000467838#ENSG00000197961#ENST00000591447#C2H2 ZF Containing Proteins#zf-H2C2_2	FALSE
474	ENSG00000196418	ZNF124	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7678	zinc finger protein 124 [Source:HGNC Symbol;Acc:HGNC:12907]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000340749#ENSG00000196418#ENST00000340684#C2H2 ZF Containing Proteins#KRAB$#ENSP00000440365#ENSG00000196418#ENST00000543802#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000462445#ENSG00000196418#ENST00000472531#C2H2 ZF Containing Proteins#KRAB$#ENSP00000463191#ENSG00000196418#ENST00000491356#C2H2 ZF Containing Proteins#KRAB	TRUE
475	ENSG00000172262	ZNF131	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Evidence for DNA binding (PMID: 20303951 ).	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	7690	zinc finger protein 131 [Source:HGNC Symbol;Acc:HGNC:12915]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000172262#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000172262#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990	$#ENSP00000422079#ENSG00000172262#ENST00000515326#C2H2 ZF Containing Proteins#BTB$#ENSP00000305804#ENSG00000172262#ENST00000306938#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000426504#ENSG00000172262#ENST00000509156#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4$#ENSP00000425722#ENSG00000172262#ENST00000509931#C2H2 ZF Containing Proteins#BTB	FALSE
476	ENSG00000131849	ZNF132	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7691	zinc finger protein 132 [Source:HGNC Symbol;Acc:HGNC:12916]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000131849#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990	$#ENSP00000254166#ENSG00000131849#ENST00000254166#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
477	ENSG00000125846	ZNF133	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7692	zinc finger protein 133 [Source:HGNC Symbol;Acc:HGNC:12917]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000125846#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990, PMID:9278146	$#ENSP00000346090#ENSG00000125846#ENST00000316358#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366899#ENSG00000125846#ENST00000377671#C2H2 ZF Containing Proteins#KRAB$#ENSP00000383945#ENSG00000125846#ENST00000401790#C2H2 ZF Containing Proteins#KRAB$#ENSP00000385279#ENSG00000125846#ENST00000402618#C2H2 ZF Containing Proteins#$#ENSP00000442978#ENSG00000125846#ENST00000538547#C2H2 ZF Containing Proteins#$#ENSP00000487315#ENSG00000125846#ENST00000628216#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485741#ENSG00000125846#ENST00000630056#C2H2 ZF Containing Proteins#$#ENSP00000400897#ENSG00000125846#ENST00000396026#C2H2 ZF Containing Proteins#KRAB$#ENSP00000406638#ENSG00000125846#ENST00000425686#C2H2 ZF Containing Proteins#KRAB$#ENSP00000403835#ENSG00000125846#ENST00000434018#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439427#ENSG00000125846#ENST00000535822#C2H2 ZF Containing Proteins#	TRUE
478	ENSG00000213762	ZNF134	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	7693	zinc finger protein 134 [Source:HGNC Symbol;Acc:HGNC:12918]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000213762#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990	$#ENSP00000379464#ENSG00000213762#ENST00000396161#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000472314#ENSG00000213762#ENST00000600344#C2H2 ZF Containing Proteins#Toxin_12$#ENSP00000469065#ENSG00000213762#ENST00000600883#C2H2 ZF Containing Proteins#	FALSE
479	ENSG00000176293	ZNF135	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7694	zinc finger protein 135 [Source:HGNC Symbol;Acc:HGNC:12919]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000176293#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:7557990	$#ENSP00000321406#ENSG00000176293#ENST00000313434#C2H2 ZF Containing Proteins#KRAB$#ENSP00000441410#ENSG00000176293#ENST00000401053#C2H2 ZF Containing Proteins#KRAB$#ENSP00000369437#ENSG00000176293#ENST00000359978#C2H2 ZF Containing Proteins#KRAB$#ENSP00000427691#ENSG00000176293#ENST00000506786#C2H2 ZF Containing Proteins#$#ENSP00000422074#ENSG00000176293#ENST00000511556#C2H2 ZF Containing Proteins#KRAB	TRUE
480	ENSG00000196646	ZNF136	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7695	zinc finger protein 136 [Source:HGNC Symbol;Acc:HGNC:12920]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000344162#ENSG00000196646#ENST00000343979#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000388759#ENSG00000196646#ENST00000439995#C2H2 ZF Containing Proteins#$#ENSP00000397176#ENSG00000196646#ENST00000418338#C2H2 ZF Containing Proteins#$#ENSP00000403707#ENSG00000196646#ENST00000425827#C2H2 ZF Containing Proteins#	TRUE
481	ENSG00000197008	ZNF138	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7697	Zinc finger protein 138 [Source:HGNC Symbol;Acc:HGNC:12922]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000197008#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990	$#ENSP00000399528#ENSG00000197008#ENST00000437743#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407262#ENSG00000197008#ENST00000440155#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415995#ENSG00000197008#ENST00000440598#C2H2 ZF Containing Proteins#KRAB$#ENSP00000419197#ENSG00000197008#ENST00000494380#C2H2 ZF Containing Proteins#KRAB	FALSE
482	ENSG00000105708	ZNF14	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR001909;IPR007087;IPR015880;	7561	zinc finger protein 14 [Source:HGNC Symbol;Acc:HGNC:12924]	None	not tested	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000340514#ENSG00000105708#ENST00000344099#C2H2 ZF Containing Proteins#KRAB	TRUE
483	ENSG00000196387	ZNF140	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	7699	zinc finger protein 140 [Source:HGNC Symbol;Acc:HGNC:12925]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000196387#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990	$#ENSP00000347755#ENSG00000196387#ENST00000355557#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415499#ENSG00000196387#ENST00000429434#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415016#ENSG00000196387#ENST00000440550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445411#ENSG00000196387#ENST00000544426#C2H2 ZF Containing Proteins#$#ENSP00000444905#ENSG00000196387#ENST00000356456#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389566#ENSG00000196387#ENST00000412146#C2H2 ZF Containing Proteins#KRAB	TRUE
484	ENSG00000131127	ZNF141	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7700	zinc finger protein 141 [Source:HGNC Symbol;Acc:HGNC:12926]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	None	$#ENSP00000240499#ENSG00000131127#ENST00000240499#C2H2 ZF Containing Proteins#KRAB$#ENSP00000425799#ENSG00000131127#ENST00000512994#C2H2 ZF Containing Proteins#KRAB$#ENSP00000424403#ENSG00000131127#ENST00000505939#C2H2 ZF Containing Proteins#KRAB	TRUE
485	ENSG00000115568	ZNF142	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	7701	zinc finger protein 142 [Source:HGNC Symbol;Acc:HGNC:12927]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	Yes	None	$#ENSP00000408643#ENSG00000115568#ENST00000449707#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5$#ENSP00000391599#ENSG00000115568#ENST00000432460#C2H2 ZF Containing Proteins#$#ENSP00000400424#ENSG00000115568#ENST00000450560#C2H2 ZF Containing Proteins#	FALSE
486	ENSG00000166478	ZNF143	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7702	zinc finger protein 143 [Source:HGNC Symbol;Acc:HGNC:12928]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000379847#ENSG00000166478#ENST00000396602#C2H2 ZF Containing Proteins#CopK$#ENSP00000432154#ENSG00000166478#ENST00000530463#C2H2 ZF Containing Proteins#CopK, FecR$#ENSP00000379843#ENSG00000166478#ENST00000396597#C2H2 ZF Containing Proteins#CopK$#ENSP00000409432#ENSG00000166478#ENST00000438144#C2H2 ZF Containing Proteins#CopK, FecR$#ENSP00000401493#ENSG00000166478#ENST00000447186#C2H2 ZF Containing Proteins#	FALSE
487	ENSG00000167635	ZNF146	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	7705	zinc finger protein 146 [Source:HGNC Symbol;Acc:HGNC:12931]	None	Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000167635#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000392095#ENSG00000167635#ENST00000443387#C2H2 ZF Containing Proteins#$#ENSP00000400391#ENSG00000167635#ENST00000456324#C2H2 ZF Containing Proteins#	FALSE
488	ENSG00000163848	ZNF148	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	7707	zinc finger protein 148 [Source:HGNC Symbol;Acc:HGNC:12933]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8355710	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000163848#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12771217	$#ENSP00000353863#ENSG00000163848#ENST00000360647#C2H2 ZF Containing Proteins#$#ENSP00000420102#ENSG00000163848#ENST00000468369#C2H2 ZF Containing Proteins#$#ENSP00000420335#ENSG00000163848#ENST00000484491#C2H2 ZF Containing Proteins#$#ENSP00000420448#ENSG00000163848#ENST00000485866#C2H2 ZF Containing Proteins#$#ENSP00000419322#ENSG00000163848#ENST00000492394#C2H2 ZF Containing Proteins#	FALSE
489	ENSG00000179909	ZNF154	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7710	zinc finger protein 154 [Source:HGNC Symbol;Acc:HGNC:12939]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000179909#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:7557990	$#ENSP00000421258#ENSG00000179909#ENST00000512439#C2H2 ZF Containing Proteins#KRAB	TRUE
490	ENSG00000204920	ZNF155	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7711	zinc finger protein 155 [Source:HGNC Symbol;Acc:HGNC:12940]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000204920#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990	$#ENSP00000270014#ENSG00000204920#ENST00000270014#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465691#ENSG00000204920#ENST00000590615#C2H2 ZF Containing Proteins#KRAB$#ENSP00000385163#ENSG00000204920#ENST00000407951#C2H2 ZF Containing Proteins#KRAB	TRUE
491	ENSG00000147117	ZNF157	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7712	zinc finger protein 157 [Source:HGNC Symbol;Acc:HGNC:12942]	None	not tested	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000147117#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8586441	$#ENSP00000366273#ENSG00000147117#ENST00000377073#C2H2 ZF Containing Proteins#KRAB	TRUE
492	ENSG00000170631	ZNF16	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	7564	zinc finger protein 16 [Source:HGNC Symbol;Acc:HGNC:12947]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000170631#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000276816#ENSG00000170631#ENST00000276816#C2H2 ZF Containing Proteins#XPA_N, zf-C2H2_6$#ENSP00000378369#ENSG00000170631#ENST00000394909#C2H2 ZF Containing Proteins#XPA_N, zf-C2H2_6$#ENSP00000434321#ENSG00000170631#ENST00000532351#C2H2 ZF Containing Proteins#$#ENSP00000484504#ENSG00000170631#ENST00000611477#C2H2 ZF Containing Proteins#XPA_N, zf-C2H2_6	FALSE
493	ENSG00000170949	ZNF160	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	90338	zinc finger protein 160 [Source:HGNC Symbol;Acc:HGNC:12948]	None	DBD and Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000347273#ENSG00000170949#ENST00000355147#C2H2 ZF Containing Proteins#KRAB$#ENSP00000409597#ENSG00000170949#ENST00000418871#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470961#ENSG00000170949#ENST00000599056#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469393#ENSG00000170949#ENST00000599247#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470573#ENSG00000170949#ENST00000601421#C2H2 ZF Containing Proteins#$#ENSP00000406201#ENSG00000170949#ENST00000429604#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470305#ENSG00000170949#ENST00000601982#C2H2 ZF Containing Proteins#KRAB	TRUE
494	ENSG00000197279	ZNF165	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain and that it appears to be expressed commonly in urinary bladder cancers PMID: 25214475	IPR003309;IPR007087;IPR008916;IPR015880	7718	zinc finger protein 165 [Source:HGNC Symbol;Acc:HGNC:12953]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000197279#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366542#ENSG00000197279#ENST00000377325#C2H2 ZF Containing Proteins#SCAN	FALSE
495	ENSG00000175787	ZNF169	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	169841	zinc finger protein 169 [Source:HGNC Symbol;Acc:HGNC:12957]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000475038#ENSG00000175787#ENST00000480716#C2H2 ZF Containing Proteins#KRAB$#ENSP00000474608#ENSG00000175787#ENST00000481550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000340711#ENSG00000175787#ENST00000340911#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378792#ENSG00000175787#ENST00000395395#C2H2 ZF Containing Proteins#KRAB	TRUE
496	ENSG00000186272	ZNF17	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7565	zinc finger protein 17 [Source:HGNC Symbol;Acc:HGNC:12958]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000302455#ENSG00000186272#ENST00000307658#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471905#ENSG00000186272#ENST00000601808#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472791#ENSG00000186272#ENST00000597350#C2H2 ZF Containing Proteins#KRAB	TRUE
497	ENSG00000103343	ZNF174	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	7727	zinc finger protein 174 [Source:HGNC Symbol;Acc:HGNC:12963]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Tim Hughes	Yes	$#ENSG00000103343#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000103343#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:7673192	$#ENSP00000268655#ENSG00000103343#ENST00000268655#C2H2 ZF Containing Proteins#SCAN$#ENSP00000339781#ENSG00000103343#ENST00000344823#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459681#ENSG00000103343#ENST00000572544#C2H2 ZF Containing Proteins#SCAN	FALSE
498	ENSG00000105497	ZNF175	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7728	zinc finger protein 175 [Source:HGNC Symbol;Acc:HGNC:12964]	None	Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000105497#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8838321	$#ENSP00000262259#ENSG00000105497#ENST00000262259#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000444424#ENSG00000105497#ENST00000545217#C2H2 ZF Containing Proteins#$#ENSP00000440578#ENSG00000105497#ENST00000436511#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470922#ENSG00000105497#ENST00000596504#C2H2 ZF Containing Proteins#KRAB	TRUE
499	ENSG00000188629	ZNF177	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	7730	zinc finger protein 177 [Source:HGNC Symbol;Acc:HGNC:12966]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000341497#ENSG00000188629#ENST00000343499#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468531#ENSG00000188629#ENST00000589262#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465438#ENSG00000188629#ENST00000590616#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467978#ENSG00000188629#ENST00000592912#C2H2 ZF Containing Proteins#	TRUE
500	ENSG00000154957	ZNF18	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7566	zinc finger protein 18 [Source:HGNC Symbol;Acc:HGNC:12969]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000154957#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000391376#ENSG00000154957#ENST00000454073#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000462296#ENSG00000154957#ENST00000580613#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000315664#ENSG00000154957#ENST00000322748#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000463471#ENSG00000154957#ENST00000580306#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000462383#ENSG00000154957#ENST00000577671#C2H2 ZF Containing Proteins#KRAB$#ENSP00000462416#ENSG00000154957#ENST00000580903#C2H2 ZF Containing Proteins#SCAN$#ENSP00000462877#ENSG00000154957#ENST00000582607#C2H2 ZF Containing Proteins#KRAB	TRUE
501	ENSG00000167384	ZNF180	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7733	Zinc finger protein 180 [Source:HGNC Symbol;Acc:HGNC:12970]	None	Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000221327#ENSG00000167384#ENST00000221327#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375818#ENSG00000167384#ENST00000391956#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468021#ENSG00000167384#ENST00000592529#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467916#ENSG00000167384#ENST00000591064#C2H2 ZF Containing Proteins#KRAB	TRUE
502	ENSG00000197841	ZNF181	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003656;IPR007087;IPR015880	339318	zinc finger protein 181 [Source:HGNC Symbol;Acc:HGNC:12971]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000419435#ENSG00000197841#ENST00000459757#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420727#ENSG00000197841#ENST00000492450#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473016#ENSG00000197841#ENST00000595708#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471063#ENSG00000197841#ENST00000593781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472046#ENSG00000197841#ENST00000599244#C2H2 ZF Containing Proteins#KRAB	TRUE
503	ENSG00000147118	ZNF182	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7569	zinc finger protein 182 [Source:HGNC Symbol;Acc:HGNC:13001]	None	Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000147118#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366142#ENSG00000147118#ENST00000376943#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380165#ENSG00000147118#ENST00000396965#C2H2 ZF Containing Proteins#KRAB	TRUE
504	ENSG00000096654	ZNF184	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7738	zinc finger protein 184 [Source:HGNC Symbol;Acc:HGNC:12975]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000211936#ENSG00000096654#ENST00000211936#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366636#ENSG00000096654#ENST00000377419#C2H2 ZF Containing Proteins#KRAB	TRUE
505	ENSG00000136870	ZNF189	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7743	zinc finger protein 189 [Source:HGNC Symbol;Acc:HGNC:12980]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000136870#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9653648	$#ENSP00000259395#ENSG00000136870#ENST00000259395#C2H2 ZF Containing Proteins#$#ENSP00000342019#ENSG00000136870#ENST00000339664#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363995#ENSG00000136870#ENST00000374861#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483461#ENSG00000136870#ENST00000615466#C2H2 ZF Containing Proteins#KRAB	TRUE
506	ENSG00000157429	ZNF19	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7567	zinc finger protein 19 [Source:HGNC Symbol;Acc:HGNC:12981]	None	Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000157429#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7557990	$#ENSP00000288177#ENSG00000157429#ENST00000288177#C2H2 ZF Containing Proteins#KRAB$#ENSP00000455575#ENSG00000157429#ENST00000564225#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458105#ENSG00000157429#ENST00000564230#C2H2 ZF Containing Proteins#KRAB$#ENSP00000454864#ENSG00000157429#ENST00000565637#C2H2 ZF Containing Proteins#$#ENSP00000462021#ENSG00000157429#ENST00000561469#C2H2 ZF Containing Proteins#KRAB$#ENSP00000462566#ENSG00000157429#ENST00000567225#C2H2 ZF Containing Proteins#KRAB	TRUE
507	ENSG00000005801	ZNF195	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Kruppel family C2H2 ZF.	IPR001909;IPR007087;IPR015880;	7748	zinc finger protein 195 [Source:HGNC Symbol;Acc:HGNC:12986]	None	Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000005082#ENSG00000005801#ENST00000005082#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000346613#ENSG00000005801#ENST00000354599#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000382511#ENSG00000005801#ENST00000399602#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000431937#ENSG00000005801#ENST00000528410#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6, zf-H2C2_2$#ENSP00000435828#ENSG00000005801#ENST00000526601#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000414353#ENSG00000005801#ENST00000438262#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433911#ENSG00000005801#ENST00000533036#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437265#ENSG00000005801#ENST00000534569#C2H2 ZF Containing Proteins#KRAB	TRUE
508	ENSG00000186448	ZNF197	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	10168	zinc finger protein 197 [Source:HGNC Symbol;Acc:HGNC:12988]	None	DBD	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000186448#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000345809#ENSG00000186448#ENST00000344387#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000373250#ENSG00000186448#ENST00000383744#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000373251#ENSG00000186448#ENST00000383745#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000379370#ENSG00000186448#ENST00000396058#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000394713#ENSG00000186448#ENST00000412641#C2H2 ZF Containing Proteins#SCAN	TRUE
509	ENSG00000275111	ZNF2	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7549	zinc finger protein 2 [Source:HGNC Symbol;Acc:HGNC:12991]	None	DBD and Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000275111#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000477960#ENSG00000275111#ENST00000611463#C2H2 ZF Containing Proteins#$#ENSP00000480297#ENSG00000275111#ENST00000614034#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480057#ENSG00000275111#ENST00000617923#C2H2 ZF Containing Proteins#$#ENSP00000482030#ENSG00000275111#ENST00000611147#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483131#ENSG00000275111#ENST00000622059#C2H2 ZF Containing Proteins#KRAB	TRUE
510	ENSG00000132010	ZNF20	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7568	zinc finger protein 20 [Source:HGNC Symbol;Acc:HGNC:12992]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000335437#ENSG00000132010#ENST00000334213#C2H2 ZF Containing Proteins#KRAB$#ENSP00000390115#ENSG00000132010#ENST00000418866#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470025#ENSG00000132010#ENST00000600335#C2H2 ZF Containing Proteins#KRAB	TRUE
511	ENSG00000010539	ZNF200	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7752	zinc finger protein 200 [Source:HGNC Symbol;Acc:HGNC:12993]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000010539#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000380077#ENSG00000010539#ENST00000396868#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380079#ENSG00000010539#ENST00000396870#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380080#ENSG00000010539#ENST00000396871#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405786#ENSG00000010539#ENST00000414144#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395723#ENSG00000010539#ENST00000431561#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458508#ENSG00000010539#ENST00000575948#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458777#ENSG00000010539#ENST00000575617#C2H2 ZF Containing Proteins#	FALSE
512	ENSG00000166261	ZNF202	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7753	zinc finger protein 202 [Source:HGNC Symbol;Acc:HGNC:12994]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000166261#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000166261#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10748193, PMID:9790754	$#ENSP00000337724#ENSG00000166261#ENST00000336139#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000432504#ENSG00000166261#ENST00000530393#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000433881#ENSG00000166261#ENST00000529691#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000431223#ENSG00000166261#ENST00000533463#C2H2 ZF Containing Proteins#SCAN	TRUE
513	ENSG00000122386	ZNF205	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7755	zinc finger protein 205 [Source:HGNC Symbol;Acc:HGNC:12996]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000122386#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000371627#ENSG00000122386#ENST00000382192#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480401#ENSG00000122386#ENST00000620094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000403306#ENSG00000122386#ENST00000414351#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394360#ENSG00000122386#ENST00000444510#C2H2 ZF Containing Proteins#	TRUE
514	ENSG00000010244	ZNF207	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	693217	zinc finger protein 207 [Source:HGNC Symbol;Acc:HGNC:12998]	None	DBD and Full	not tested	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	No	$#ENSG00000010244#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9799612	$#ENSP00000322777#ENSG00000010244#ENST00000321233#C2H2 ZF Containing Proteins#$#ENSP00000378165#ENSG00000010244#ENST00000394670#C2H2 ZF Containing Proteins#$#ENSP00000378168#ENSG00000010244#ENST00000394673#C2H2 ZF Containing Proteins#$#ENSP00000378172#ENSG00000010244#ENST00000394679#C2H2 ZF Containing Proteins#$#ENSP00000463040#ENSG00000010244#ENST00000579634#C2H2 ZF Containing Proteins#	FALSE
515	ENSG00000160321	ZNF208	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7757	zinc finger protein 208 [Source:HGNC Symbol;Acc:HGNC:12999]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000469254#ENSG00000160321#ENST00000599916#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472406#ENSG00000160321#ENST00000597040#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469887#ENSG00000160321#ENST00000601773#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380315#ENSG00000160321#ENST00000397126#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000473026#ENSG00000160321#ENST00000599723#C2H2 ZF Containing Proteins#KRAB	TRUE
516	ENSG00000121417	ZNF211	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	10520	zinc finger protein 211 [Source:HGNC Symbol;Acc:HGNC:13003]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000121417#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000339562#ENSG00000121417#ENST00000347302#C2H2 ZF Containing Proteins#KRAB$#ENSP00000384436#ENSG00000121417#ENST00000407202#C2H2 ZF Containing Proteins#KRAB$#ENSP00000240731#ENSG00000121417#ENST00000240731#C2H2 ZF Containing Proteins#KRAB$#ENSP00000254182#ENSG00000121417#ENST00000254182#C2H2 ZF Containing Proteins#$#ENSP00000375584#ENSG00000121417#ENST00000391703#C2H2 ZF Containing Proteins#$#ENSP00000299871#ENSG00000121417#ENST00000299871#C2H2 ZF Containing Proteins#KRAB$#ENSP00000442601#ENSG00000121417#ENST00000541801#C2H2 ZF Containing Proteins#KRAB	TRUE
517	ENSG00000170260	ZNF212	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;IPR022137	7988	zinc finger protein 212 [Source:HGNC Symbol;Acc:HGNC:13004]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000338572#ENSG00000170260#ENST00000335870#C2H2 ZF Containing Proteins#DUF3669, KRAB, zf-C2H2_4, zf-C2H2_6, zf-C2HC_2, zf$#ENSP00000419419#ENSG00000170260#ENST00000481584#C2H2 ZF Containing Proteins#KRAB	TRUE
518	ENSG00000085644	ZNF213	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE); Has a putative AT-hook	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7760	zinc finger protein 213 [Source:HGNC Symbol;Acc:HGNC:13005]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000085644#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000380087#ENSG00000085644#ENST00000396878#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000459233#ENSG00000085644#ENST00000572647#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459177#ENSG00000085644#ENST00000576416#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000459293#ENSG00000085644#ENST00000574575#C2H2 ZF Containing Proteins#	TRUE
519	ENSG00000149050	ZNF214	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7761	zinc finger protein 214 [Source:HGNC Symbol;Acc:HGNC:13006]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000278314#ENSG00000149050#ENST00000278314#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445373#ENSG00000149050#ENST00000536068#C2H2 ZF Containing Proteins#KRAB	TRUE
520	ENSG00000149054	ZNF215	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7762	zinc finger protein 215 [Source:HGNC Symbol;Acc:HGNC:13007]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	Yes	$#ENSG00000149054#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:10762538	$#ENSP00000278319#ENSG00000149054#ENST00000278319#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000432306#ENSG00000149054#ENST00000529903#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000393202#ENSG00000149054#ENST00000414517#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000484674#ENSG00000149054#ENST00000610573#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
521	ENSG00000171940	ZNF217	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Based on (PDB: 3UK3) this protein has at least two DNA binding znf domains. In vitro evidence for DNA binding (PMID:17130829).	IPR007087;IPR015880	7764	zinc finger protein 217 [Source:HGNC Symbol;Acc:HGNC:13009]	3UK3	DBD and Full	not tested	None	Crystal has two single znfC2H2 domains	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000171940#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17130829$#ENSG00000171940#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9671742	$#ENSP00000304308#ENSG00000171940#ENST00000302342#C2H2 ZF Containing Proteins#$#ENSP00000394010#ENSG00000171940#ENST00000437222#C2H2 ZF Containing Proteins#$#ENSP00000360526#ENSG00000171940#ENST00000371471#C2H2 ZF Containing Proteins#$#ENSP00000399672#ENSG00000171940#ENST00000431687#C2H2 ZF Containing Proteins#	FALSE
522	ENSG00000165804	ZNF219	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds  CCCCCA based on SELEX (PMID: 14621294).	IPR003980;IPR007087;IPR015880;	51222	zinc finger protein 219 [Source:HGNC Symbol;Acc:HGNC:13011]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000165804#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14621294$#ENSG00000165804#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14621294, PMID:19549071	$#ENSP00000354206#ENSG00000165804#ENST00000360947#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000392401#ENSG00000165804#ENST00000421093#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000450900#ENSG00000165804#ENST00000553296#C2H2 ZF Containing Proteins#$#ENSP00000451595#ENSG00000165804#ENST00000555697#C2H2 ZF Containing Proteins#	FALSE
523	ENSG00000165512	ZNF22	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	7570	zinc finger protein 22 [Source:HGNC Symbol;Acc:HGNC:13012]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__DNA Binding_PMIDS:12952191	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000298299#ENSG00000165512#ENST00000298299#C2H2 ZF Containing Proteins#	FALSE
524	ENSG00000159905	ZNF221	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7638	Zinc finger protein 221 [Source:HGNC Symbol;Acc:HGNC:13014]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	Yes	$#ENSG00000159905#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000251269#ENSG00000159905#ENST00000251269#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467367#ENSG00000159905#ENST00000587682#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467446#ENSG00000159905#ENST00000592350#C2H2 ZF Containing Proteins#KRAB$#ENSP00000477876#ENSG00000159905#ENST00000622072#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464885#ENSG00000159905#ENST00000591168#C2H2 ZF Containing Proteins#KRAB	FALSE
525	ENSG00000159885	ZNF222	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7673	zinc finger protein 222 [Source:HGNC Symbol;Acc:HGNC:13015]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000187879#ENSG00000159885#ENST00000187879#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000375822#ENSG00000159885#ENST00000391960#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000466778#ENSG00000159885#ENST00000587846#C2H2 ZF Containing Proteins#KRAB	TRUE
526	ENSG00000178386	ZNF223	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7766	zinc finger protein 223 [Source:HGNC Symbol;Acc:HGNC:13016]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000178386#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000401947#ENSG00000178386#ENST00000434772#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467647#ENSG00000178386#ENST00000591850#C2H2 ZF Containing Proteins#$#ENSP00000467561#ENSG00000178386#ENST00000585552#C2H2 ZF Containing Proteins#KRAB	TRUE
527	ENSG00000267680	ZNF224	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7767	zinc finger protein 224 [Source:HGNC Symbol;Acc:HGNC:13017]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000267680#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000337368#ENSG00000267680#ENST00000336976#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466961#ENSG00000267680#ENST00000591511#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465000#ENSG00000267680#ENST00000589680#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465886#ENSG00000267680#ENST00000589870#C2H2 ZF Containing Proteins#KRAB	TRUE
528	ENSG00000256294	ZNF225	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7768	zinc finger protein 225 [Source:HGNC Symbol;Acc:HGNC:13018]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000256294#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000262894#ENSG00000256294#ENST00000262894#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468686#ENSG00000256294#ENST00000590612#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468414#ENSG00000256294#ENST00000588926#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466853#ENSG00000256294#ENST00000589155#C2H2 ZF Containing Proteins#KRAB	TRUE
529	ENSG00000167380	ZNF226	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7769	zinc finger protein 226 [Source:HGNC Symbol;Acc:HGNC:13019]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000167380#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000300823#ENSG00000167380#ENST00000300823#C2H2 ZF Containing Proteins#KRAB$#ENSP00000336719#ENSG00000167380#ENST00000337433#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393265#ENSG00000167380#ENST00000454662#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467003#ENSG00000167380#ENST00000588742#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464735#ENSG00000167380#ENST00000588795#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465401#ENSG00000167380#ENST00000588883#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465121#ENSG00000167380#ENST00000590089#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468779#ENSG00000167380#ENST00000590578#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407474#ENSG00000167380#ENST00000413984#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467766#ENSG00000167380#ENST00000590524#C2H2 ZF Containing Proteins#KRAB	TRUE
530	ENSG00000131115	ZNF227	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7770	zinc finger protein 227 [Source:HGNC Symbol;Acc:HGNC:13020]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000131115#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000321049#ENSG00000131115#ENST00000313040#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467496#ENSG00000131115#ENST00000586228#C2H2 ZF Containing Proteins#$#ENSP00000464866#ENSG00000131115#ENST00000588219#C2H2 ZF Containing Proteins#$#ENSP00000467577#ENSG00000131115#ENST00000589005#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000482749#ENSG00000131115#ENST00000621083#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000464800#ENSG00000131115#ENST00000586048#C2H2 ZF Containing Proteins#KRAB	TRUE
531	ENSG00000278318	ZNF229	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	7772	Zinc finger protein 229 [Source:HGNC Symbol;Acc:HGNC:13022]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000278318#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000479807#ENSG00000278318#ENST00000613197#C2H2 ZF Containing Proteins#KRAB$#ENSP00000479884#ENSG00000278318#ENST00000614049#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464902#ENSG00000278318#ENST00000592308#C2H2 ZF Containing Proteins#	TRUE
532	ENSG00000167377	ZNF23	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	7571	zinc finger protein 23 [Source:HGNC Symbol;Acc:HGNC:13023]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000167377#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000377171#ENSG00000167377#ENST00000393539#C2H2 ZF Containing Proteins#$#ENSP00000387673#ENSG00000167377#ENST00000428724#C2H2 ZF Containing Proteins#$#ENSP00000462429#ENSG00000167377#ENST00000564528#C2H2 ZF Containing Proteins#$#ENSP00000349796#ENSG00000167377#ENST00000357254#C2H2 ZF Containing Proteins#	TRUE
533	ENSG00000159882	ZNF230	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has nice array of znf domains and a KRAB domain	IPR001909;IPR007087;IPR015880;	7773	zinc finger protein 230 [Source:HGNC Symbol;Acc:HGNC:13024]	None	DBD and Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000409318#ENSG00000159882#ENST00000429154#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000466541#ENSG00000159882#ENST00000585491#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465988#ENSG00000159882#ENST00000585632#C2H2 ZF Containing Proteins#KRAB	TRUE
534	ENSG00000167840	ZNF232	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	7775	zinc finger protein 232 [Source:HGNC Symbol;Acc:HGNC:13026], alternative symbol is ZSCAN11	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000167840#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000461305#ENSG00000167840#ENST00000575898#C2H2 ZF Containing Proteins#SCAN$#ENSP00000250076#ENSG00000167840#ENST00000250076#C2H2 ZF Containing Proteins#SCAN	FALSE
535	ENSG00000159915	ZNF233	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	353355	zinc finger protein 233 [Source:HGNC Symbol;Acc:HGNC:30946]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000375820#ENSG00000159915#ENST00000391958#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465307#ENSG00000159915#ENST00000589522#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468154#ENSG00000159915#ENST00000592581#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466781#ENSG00000159915#ENST00000590668#C2H2 ZF Containing Proteins#KRAB	TRUE
536	ENSG00000263002	ZNF234	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	10780	Zinc finger protein 234 [Source:HGNC Symbol;Acc:HGNC:13027]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000263002#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000400878#ENSG00000263002#ENST00000426739#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465011#ENSG00000263002#ENST00000592437#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
537	ENSG00000159917	ZNF235	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	9310	zinc finger protein 235 [Source:HGNC Symbol;Acc:HGNC:12866]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000159917#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000291182#ENSG00000159917#ENST00000291182#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468695#ENSG00000159917#ENST00000589799#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468609#ENSG00000159917#ENST00000589248#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465880#ENSG00000159917#ENST00000591609#C2H2 ZF Containing Proteins#KRAB	TRUE
538	ENSG00000130856	ZNF236	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	7776	zinc finger protein 236 [Source:HGNC Symbol;Acc:HGNC:13028]	None	Full	not tested	None	None	a	Yes	No	No	2a1, Lower confidence direct evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000253159#ENSG00000130856#ENST00000253159#C2H2 ZF Containing Proteins#$#ENSP00000322361#ENSG00000130856#ENST00000320610#C2H2 ZF Containing Proteins#$#ENSP00000463787#ENSG00000130856#ENST00000579322#C2H2 ZF Containing Proteins#	FALSE
539	ENSG00000196793	ZNF239	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds TAAAGGCT based on EMSA (PMID: 11278819).	IPR007087;IPR015880	8187	zinc finger protein 239 [Source:HGNC Symbol;Acc:HGNC:13031]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:11278819	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000196793#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000307774#ENSG00000196793#ENST00000306006#C2H2 ZF Containing Proteins#$#ENSP00000363569#ENSG00000196793#ENST00000374446#C2H2 ZF Containing Proteins#$#ENSP00000398202#ENSG00000196793#ENST00000426961#C2H2 ZF Containing Proteins#$#ENSP00000443907#ENSG00000196793#ENST00000535642#C2H2 ZF Containing Proteins#	FALSE
540	ENSG00000172466	ZNF24	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003309;IPR007087;IPR008916;IPR015880	7572	zinc finger protein 24 [Source:HGNC Symbol;Acc:HGNC:13032]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000172466#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000261332#ENSG00000172466#ENST00000261332#C2H2 ZF Containing Proteins#SCAN$#ENSP00000382015#ENSG00000172466#ENST00000399061#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467655#ENSG00000172466#ENST00000589881#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467608#ENSG00000172466#ENST00000589539#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467432#ENSG00000172466#ENST00000590140#C2H2 ZF Containing Proteins#SCAN	FALSE
541	ENSG00000198105	ZNF248	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	57209	zinc finger protein 248 [Source:HGNC Symbol;Acc:HGNC:13041]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000363778#ENSG00000198105#ENST00000374648#C2H2 ZF Containing Proteins#KRAB$#ENSP00000379208#ENSG00000198105#ENST00000395867#C2H2 ZF Containing Proteins#KRAB, zf-AN1, zf-C2H2_4, zf-C2H2_6$#ENSP00000484191#ENSG00000198105#ENST00000611278#C2H2 ZF Containing Proteins#KRAB$#ENSP00000349882#ENSG00000198105#ENST00000357328#C2H2 ZF Containing Proteins#KRAB, zf-AN1, zf-C2H2_4, zf-C2H2_6$#ENSP00000379214#ENSG00000198105#ENST00000395873#C2H2 ZF Containing Proteins#KRAB$#ENSP00000379215#ENSG00000198105#ENST00000395874#C2H2 ZF Containing Proteins#KRAB	TRUE
542	ENSG00000175395	ZNF25	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	219749	zinc finger protein 25 [Source:HGNC Symbol;Acc:HGNC:13043]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000302222#ENSG00000175395#ENST00000302609#C2H2 ZF Containing Proteins#KRAB	TRUE
543	ENSG00000196150	ZNF250	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	58500	zinc finger protein 250 [Source:HGNC Symbol;Acc:HGNC:13044]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000196150#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000292579#ENSG00000196150#ENST00000292579#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393442#ENSG00000196150#ENST00000417550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433725#ENSG00000196150#ENST00000527049#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432702#ENSG00000196150#ENST00000533221#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433387#ENSG00000196150#ENST00000533622#C2H2 ZF Containing Proteins#KRAB	TRUE
544	ENSG00000198169	ZNF251	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	90987	zinc finger protein 251 [Source:HGNC Symbol;Acc:HGNC:13045]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000198169#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000292562#ENSG00000198169#ENST00000292562#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000431809#ENSG00000198169#ENST00000525191#C2H2 ZF Containing Proteins#KRAB	TRUE
545	ENSG00000256771	ZNF253	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR000754;IPR001909;IPR007087;IPR015880;IPR020568;	56242	zinc finger protein 90 [Source:HGNC Symbol;Acc:HGNC:13165]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000347868#ENSG00000256771#ENST00000355650#C2H2 ZF Containing Proteins#$#ENSP00000468720#ENSG00000256771#ENST00000589717#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467235#ENSG00000256771#ENST00000592725#C2H2 ZF Containing Proteins#	TRUE
546	ENSG00000213096	ZNF254	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	9534	zinc finger protein 254 [Source:HGNC Symbol;Acc:HGNC:13047]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000213096#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000341573#ENSG00000213096#ENST00000339642#C2H2 ZF Containing Proteins#KRAB$#ENSP00000349494#ENSG00000213096#ENST00000357002#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483222#ENSG00000213096#ENST00000611359#C2H2 ZF Containing Proteins#$#ENSP00000482703#ENSG00000213096#ENST00000613065#C2H2 ZF Containing Proteins#	TRUE
547	ENSG00000152454	ZNF256	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	10172	zinc finger protein 256 [Source:HGNC Symbol;Acc:HGNC:13049]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000152454#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10585455	$#ENSP00000282308#ENSG00000152454#ENST00000282308#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472858#ENSG00000152454#ENST00000598928#C2H2 ZF Containing Proteins#	TRUE
548	ENSG00000197134	ZNF257	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	113835	zinc finger protein 257 [Source:HGNC Symbol;Acc:HGNC:13498]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000471334#ENSG00000197134#ENST00000597927#C2H2 ZF Containing Proteins#$#ENSP00000469703#ENSG00000197134#ENST00000600162#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470209#ENSG00000197134#ENST00000594947#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469454#ENSG00000197134#ENST00000594363#C2H2 ZF Containing Proteins#KRAB	TRUE
549	ENSG00000198393	ZNF26	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7574	zinc finger protein 26 [Source:HGNC Symbol;Acc:HGNC:13053]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000198393#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000333725#ENSG00000198393#ENST00000328654#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437420#ENSG00000198393#ENST00000534834#C2H2 ZF Containing Proteins#KRAB$#ENSP00000443888#ENSG00000198393#ENST00000540238#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445494#ENSG00000198393#ENST00000544181#C2H2 ZF Containing Proteins#KRAB	TRUE
550	ENSG00000254004	ZNF260	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	339324	zinc finger protein 260 [Source:HGNC Symbol;Acc:HGNC:13499]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000254004#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000464964#ENSG00000254004#ENST00000592282#C2H2 ZF Containing Proteins#$#ENSP00000465834#ENSG00000254004#ENST00000593142#C2H2 ZF Containing Proteins#$#ENSP00000429803#ENSG00000254004#ENST00000523638#C2H2 ZF Containing Proteins#$#ENSP00000467219#ENSG00000254004#ENST00000588993#C2H2 ZF Containing Proteins#	FALSE
551	ENSG00000006194	ZNF263	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	10127	zinc finger protein 263 [Source:HGNC Symbol;Acc:HGNC:13056]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12024037	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000006194#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000219069#ENSG00000006194#ENST00000219069#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000444497#ENSG00000006194#ENST00000538765#C2H2 ZF Containing Proteins#$#ENSP00000461861#ENSG00000006194#ENST00000572748#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459998#ENSG00000006194#ENST00000574253#C2H2 ZF Containing Proteins#SCAN$#ENSP00000461755#ENSG00000006194#ENST00000574674#C2H2 ZF Containing Proteins#$#ENSP00000458214#ENSG00000006194#ENST00000575823#C2H2 ZF Containing Proteins#SCAN$#ENSP00000461146#ENSG00000006194#ENST00000575332#C2H2 ZF Containing Proteins#	TRUE
552	ENSG00000083844	ZNF264	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	9422	zinc finger protein 264 [Source:HGNC Symbol;Acc:HGNC:13057]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000440376#ENSG00000083844#ENST00000536056#C2H2 ZF Containing Proteins#KRAB$#ENSP00000263095#ENSG00000083844#ENST00000263095#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471630#ENSG00000083844#ENST00000599653#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470759#ENSG00000083844#ENST00000600531#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469130#ENSG00000083844#ENST00000594126#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470587#ENSG00000083844#ENST00000597447#C2H2 ZF Containing Proteins#KRAB	TRUE
553	ENSG00000174652	ZNF266	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003656;IPR007087;IPR015880	10781	zinc finger protein 266 [Source:HGNC Symbol;Acc:HGNC:13059]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000467151#ENSG00000174652#ENST00000588933#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000467315#ENSG00000174652#ENST00000590306#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000467923#ENSG00000174652#ENST00000591213#C2H2 ZF Containing Proteins#$#ENSP00000466714#ENSG00000174652#ENST00000592904#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000468491#ENSG00000174652#ENST00000588221#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
554	ENSG00000185947	ZNF267	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	10308	zinc finger protein 267 [Source:HGNC Symbol;Acc:HGNC:13060]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000185947#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000300870#ENSG00000185947#ENST00000300870#C2H2 ZF Containing Proteins#KRAB$#ENSP00000461286#ENSG00000185947#ENST00000394846#C2H2 ZF Containing Proteins#KRAB$#ENSP00000455493#ENSG00000185947#ENST00000562971#C2H2 ZF Containing Proteins#KRAB	TRUE
555	ENSG00000090612	ZNF268	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains znfC2H2 domains and a KRAB-domain; linked to cervical cancer through effects on NFKB-signaling (PMID: 23091055).	IPR001909;IPR007087;IPR015880;	10795	zinc finger protein 268 [Source:HGNC Symbol;Acc:HGNC:13061]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000090612#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:11311945	$##ENSG00000090612##C2H2 ZF Containing Proteins#	TRUE
556	ENSG00000198039	ZNF273	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	10793	zinc finger protein 273 [Source:HGNC Symbol;Acc:HGNC:13067]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000418719#ENSG00000198039#ENST00000476120#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
557	ENSG00000171606	ZNF274	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	10782	zinc finger protein 274 [Source:HGNC Symbol;Acc:HGNC:13068]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:10777669	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000171606#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000171606#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10777669	$#ENSP00000321209#ENSG00000171606#ENST00000326804#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000321187#ENSG00000171606#ENST00000345813#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000409872#ENSG00000171606#ENST00000424679#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000484810#ENSG00000171606#ENST00000617501#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
558	ENSG00000063587	ZNF275	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	105373378	zinc finger protein 275 [Source:HGNC Symbol;Acc:HGNC:13069]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000063587#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000359269#ENSG00000063587#ENST00000370249#C2H2 ZF Containing Proteins#HypA$#ENSP00000359271#ENSG00000063587#ENST00000370251#C2H2 ZF Containing Proteins#	FALSE
559	ENSG00000158805	ZNF276	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR012934;IPR015880;	92822	zinc finger protein 276 [Source:HGNC Symbol;Acc:HGNC:23330]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000289816#ENSG00000158805#ENST00000289816#C2H2 ZF Containing Proteins#zf-AD$#ENSP00000415836#ENSG00000158805#ENST00000443381#C2H2 ZF Containing Proteins#zf-AD$#ENSP00000457210#ENSG00000158805#ENST00000568064#C2H2 ZF Containing Proteins#zf-AD	FALSE
560	ENSG00000198538	ZNF28	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7576	zinc finger protein 28 [Source:HGNC Symbol;Acc:HGNC:13073]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000198538#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000397693#ENSG00000198538#ENST00000457749#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375661#ENSG00000198538#ENST00000391783#C2H2 ZF Containing Proteins#$#ENSP00000412143#ENSG00000198538#ENST00000438150#C2H2 ZF Containing Proteins#$#ENSP00000344777#ENSG00000198538#ENST00000339844#C2H2 ZF Containing Proteins#KRAB	TRUE
561	ENSG00000169548	ZNF280A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR007087;IPR015880;IPR025243;	129025	zinc finger protein 280A [Source:HGNC Symbol;Acc:HGNC:18597]	None	Full	not tested	None	None	b	No	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000169548#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000302855#ENSG00000169548#ENST00000302097#C2H2 ZF Containing Proteins#DUF4195, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2	FALSE
562	ENSG00000275004	ZNF280B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	None	140883	Zinc finger protein 280B	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000275004#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$##ENSG00000275004##C2H2 ZF Containing Proteins#	FALSE
563	ENSG00000056277	ZNF280C	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880;IPR025243;	55609	zinc finger protein 280C [Source:HGNC Symbol;Acc:HGNC:25955]	None	Full	Yes	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000056277#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000360017#ENSG00000056277#ENST00000370978#C2H2 ZF Containing Proteins#DUF4195, zf-C2H2_4, zf-Di19$#ENSP00000408521#ENSG00000056277#ENST00000447817#C2H2 ZF Containing Proteins#DUF4195	FALSE
564	ENSG00000137871	ZNF280D	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880;IPR025243;	145783	zinc finger protein 280D [Source:HGNC Symbol;Acc:HGNC:25953]	None	not tested	not tested	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000137871#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000267807#ENSG00000137871#ENST00000267807#C2H2 ZF Containing Proteins#DUF4195, zf-Di19, zf-H2C2_2$#ENSP00000453706#ENSG00000137871#ENST00000558320#C2H2 ZF Containing Proteins#DUF4195$#ENSP00000454111#ENSG00000137871#ENST00000559237#C2H2 ZF Containing Proteins#DUF4195, zf-Di19, zf-H2C2_2$#ENSP00000453045#ENSG00000137871#ENST00000559000#C2H2 ZF Containing Proteins#DUF4195, zf-Di19, zf-H2C2_2	FALSE
565	ENSG00000162702	ZNF281	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	23528	zinc finger protein 281 [Source:HGNC Symbol;Acc:HGNC:13075]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000162702#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10448078$#ENSG00000162702#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10448078	$#ENSP00000294740#ENSG00000162702#ENST00000294740#C2H2 ZF Containing Proteins#$#ENSP00000356322#ENSG00000162702#ENST00000367353#C2H2 ZF Containing Proteins#$#ENSP00000356321#ENSG00000162702#ENST00000367352#C2H2 ZF Containing Proteins#	FALSE
566	ENSG00000170265	ZNF282	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;IPR022137	8427	zinc finger protein 282 [Source:HGNC Symbol;Acc:HGNC:13076]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000477841#ENSG00000170265#ENST00000610704#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000418840#ENSG00000170265#ENST00000479907#C2H2 ZF Containing Proteins#DUF3669, KRAB	TRUE
567	ENSG00000167637	ZNF283	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284349	zinc finger protein 283 [Source:HGNC Symbol;Acc:HGNC:13077]	None	DBD	not tested	None	None	b	No	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000167637#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000167637##C2H2 ZF Containing Proteins#	TRUE
568	ENSG00000186026	ZNF284	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	342909	zinc finger protein 284 [Source:HGNC Symbol;Acc:HGNC:13078]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000186026#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000411032#ENSG00000186026#ENST00000421176#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
569	ENSG00000267508	ZNF285	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880	26974	Zinc finger protein 285 [Source:HGNC Symbol;Acc:HGNC:13079]	None	Full	not tested	None	None	No	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000483662#ENSG00000267508#ENST00000614994#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000468399#ENSG00000267508#ENST00000585868#C2H2 ZF Containing Proteins#$#ENSP00000464788#ENSG00000267508#ENST00000591679#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000439431#ENSG00000267508#ENST00000544719#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2	TRUE
570	ENSG00000187607	ZNF286A	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	57335	zinc finger protein 286A [Source:HGNC Symbol;Acc:HGNC:13501]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000187607#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000379231#ENSG00000187607#ENST00000395894#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464218#ENSG00000187607#ENST00000464847#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467116#ENSG00000187607#ENST00000481540#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464063#ENSG00000187607#ENST00000583566#C2H2 ZF Containing Proteins#KRAB$#ENSP00000461982#ENSG00000187607#ENST00000472486#C2H2 ZF Containing Proteins#KRAB$#ENSP00000379230#ENSG00000187607#ENST00000395893#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466154#ENSG00000187607#ENST00000593105#C2H2 ZF Containing Proteins#KRAB	TRUE
571	ENSG00000249459	ZNF286B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	729288	zinc finger protein 286B [Source:HGNC Symbol;Acc:HGNC:33241]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000249459#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000463300#ENSG00000249459#ENST00000583002#C2H2 ZF Containing Proteins#$#ENSP00000460210#ENSG00000249459#ENST00000285274#C2H2 ZF Containing Proteins#RNA_pol_A_CTD$#ENSP00000460736#ENSG00000249459#ENST00000443457#C2H2 ZF Containing Proteins#	FALSE
572	ENSG00000141040	ZNF287	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	57336	Zinc finger protein 287 [Source:HGNC Symbol;Acc:HGNC:13502]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000141040#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000379168#ENSG00000141040#ENST00000395824#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000379169#ENSG00000141040#ENST00000395825#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000406051#ENSG00000141040#ENST00000448349#C2H2 ZF Containing Proteins#	TRUE
573	ENSG00000188994	ZNF292	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	23036	zinc finger protein 292 [Source:HGNC Symbol;Acc:HGNC:18410]	None	not tested	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000188994#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000430569#ENSG00000188994#ENST00000392985#C2H2 ZF Containing Proteins#$#ENSP00000358590#ENSG00000188994#ENST00000369577#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_5$#ENSP00000428857#ENSG00000188994#ENST00000496806#C2H2 ZF Containing Proteins#$#ENSP00000428925#ENSG00000188994#ENST00000518845#C2H2 ZF Containing Proteins#	FALSE
574	ENSG00000170684	ZNF296	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	162979	zinc finger protein 296 [Source:HGNC Symbol;Acc:HGNC:15981]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000302770#ENSG00000170684#ENST00000303809#C2H2 ZF Containing Proteins#$#ENSP00000479435#ENSG00000170684#ENST00000622376#C2H2 ZF Containing Proteins#	FALSE
575	ENSG00000166526	ZNF3	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7551	zinc finger protein 3 [Source:HGNC Symbol;Acc:HGNC:13089]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000166526#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000299667#ENSG00000166526#ENST00000299667#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416088#ENSG00000166526#ENST00000412947#C2H2 ZF Containing Proteins#KRAB$#ENSP00000399951#ENSG00000166526#ENST00000413658#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416686#ENSG00000166526#ENST00000415068#C2H2 ZF Containing Proteins#KRAB$#ENSP00000292393#ENSG00000166526#ENST00000292393#C2H2 ZF Containing Proteins#$#ENSP00000388042#ENSG00000166526#ENST00000428683#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415358#ENSG00000166526#ENST00000424697#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405970#ENSG00000166526#ENST00000449785#C2H2 ZF Containing Proteins#KRAB	TRUE
576	ENSG00000168661	ZNF30	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	90075	zinc finger protein 30 [Source:HGNC Symbol;Acc:HGNC:13090]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000168661#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000303889#ENSG00000168661#ENST00000303586#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469954#ENSG00000168661#ENST00000601142#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470094#ENSG00000168661#ENST00000601957#C2H2 ZF Containing Proteins#KRAB$#ENSP00000476813#ENSG00000168661#ENST00000601540#C2H2 ZF Containing Proteins#KRAB	TRUE
577	ENSG00000145908	ZNF300	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	91975	zinc finger protein 300 [Source:HGNC Symbol;Acc:HGNC:13091]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000145908#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000274599#ENSG00000145908#ENST00000274599#C2H2 ZF Containing Proteins#KRAB$#ENSP00000397178#ENSG00000145908#ENST00000446148#C2H2 ZF Containing Proteins#KRAB$#ENSP00000392593#ENSG00000145908#ENST00000418587#C2H2 ZF Containing Proteins#$#ENSP00000414195#ENSG00000145908#ENST00000427179#C2H2 ZF Containing Proteins#KRAB	TRUE
578	ENSG00000089335	ZNF302	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	55900	zinc finger protein 302 [Source:HGNC Symbol;Acc:HGNC:13848]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000089335#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000405219#ENSG00000089335#ENST00000423823#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391067#ENSG00000089335#ENST00000457781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421028#ENSG00000089335#ENST00000505242#C2H2 ZF Containing Proteins#KRAB$#ENSP00000396379#ENSG00000089335#ENST00000446502#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423235#ENSG00000089335#ENST00000505365#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421201#ENSG00000089335#ENST00000507959#C2H2 ZF Containing Proteins#KRAB$#ENSP00000424292#ENSG00000089335#ENST00000506901#C2H2 ZF Containing Proteins#KRAB	TRUE
579	ENSG00000131845	ZNF304	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	57343	zinc finger protein 304 [Source:HGNC Symbol;Acc:HGNC:13505]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000131845#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000401642#ENSG00000131845#ENST00000443917#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470319#ENSG00000131845#ENST00000598744#C2H2 ZF Containing Proteins#$#ENSP00000282286#ENSG00000131845#ENST00000282286#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375586#ENSG00000131845#ENST00000391705#C2H2 ZF Containing Proteins#KRAB	TRUE
580	ENSG00000197935	ZNF311	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	282890	zinc finger protein 311 [Source:HGNC Symbol;Acc:HGNC:13847]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000197935#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366384#ENSG00000197935#ENST00000377179#C2H2 ZF Containing Proteins#KRAB	TRUE
581	ENSG00000205903	ZNF316	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001909;IPR007087;IPR015880;	100131017	zinc finger protein 316 [Source:HGNC Symbol;Acc:HGNC:13843]	None	not tested	not tested	None	None	c	Yes	No	No	2a1, Lower confidence direct evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000482395#ENSG00000205903#ENST00000427912#C2H2 ZF Containing Proteins#$#ENSP00000477706#ENSG00000205903#ENST00000382252#C2H2 ZF Containing Proteins#KRAB	TRUE
582	ENSG00000130803	ZNF317	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	57693	zinc finger protein 317 [Source:HGNC Symbol;Acc:HGNC:13507]	None	Full	not tested	None	The ChIP-seq model is similar to SOX-motif	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000130803#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000247956#ENSG00000130803#ENST00000247956#C2H2 ZF Containing Proteins#KRAB$#ENSP00000353554#ENSG00000130803#ENST00000360385#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468213#ENSG00000130803#ENST00000591508#C2H2 ZF Containing Proteins#	TRUE
583	ENSG00000171467	ZNF318	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Possible RNA-binding protein; it has two u1 type ZNF domains (PMID: 25057009).	IPR003604;	24149	zinc finger protein 318 [Source:HGNC Symbol;Acc:HGNC:13578]	None	DBD	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000354964#ENSG00000171467#ENST00000361428#C2H2 ZF Containing Proteins#FAM177, zf-U1$#ENSP00000475511#ENSG00000171467#ENST00000606599#C2H2 ZF Containing Proteins#zf-C2H2_2	FALSE
584	ENSG00000166188	ZNF319	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	57567	zinc finger protein 319 [Source:HGNC Symbol;Acc:HGNC:13644]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000299237#ENSG00000166188#ENST00000299237#C2H2 ZF Containing Proteins#$#ENSP00000457048#ENSG00000166188#ENST00000562909#C2H2 ZF Containing Proteins#	FALSE
585	ENSG00000169740	ZNF32	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7580	zinc finger protein 32 [Source:HGNC Symbol;Acc:HGNC:13095]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000363556#ENSG00000169740#ENST00000374433#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-LYAR$#ENSP00000379143#ENSG00000169740#ENST00000395797#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-LYAR	FALSE
586	ENSG00000182986	ZNF320	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	162967	zinc finger protein 320 [Source:HGNC Symbol;Acc:HGNC:13842]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000182986#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000375660#ENSG00000182986#ENST00000391781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473091#ENSG00000182986#ENST00000595635#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470403#ENSG00000182986#ENST00000594741#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468995#ENSG00000182986#ENST00000597091#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000471938#ENSG00000182986#ENST00000597265#C2H2 ZF Containing Proteins#KRAB	TRUE
587	ENSG00000181315	ZNF322	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	79692	zinc finger protein 322 [Source:HGNC Symbol;Acc:HGNC:23640]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000181315#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000418897#ENSG00000181315#ENST00000415922#C2H2 ZF Containing Proteins#C1_4$#ENSP00000478899#ENSG00000181315#ENST00000456172#C2H2 ZF Containing Proteins#C1_4	FALSE
588	ENSG00000083812	ZNF324	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	25799	zinc finger protein 324 [Source:HGNC Symbol;Acc:HGNC:14096]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Pratyush Das	Yes	None	$#ENSP00000196482#ENSG00000083812#ENST00000196482#C2H2 ZF Containing Proteins#KRAB$#ENSP00000444812#ENSG00000083812#ENST00000536459#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471778#ENSG00000083812#ENST00000593925#C2H2 ZF Containing Proteins#$#ENSP00000439588#ENSG00000083812#ENST00000535298#C2H2 ZF Containing Proteins#KRAB	TRUE
589	ENSG00000249471	ZNF324B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	388569	zinc finger protein 324B [Source:HGNC Symbol;Acc:HGNC:33107]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000337473#ENSG00000249471#ENST00000336614#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438930#ENSG00000249471#ENST00000545523#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471086#ENSG00000249471#ENST00000594214#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473115#ENSG00000249471#ENST00000599193#C2H2 ZF Containing Proteins#KRAB	TRUE
590	ENSG00000162664	ZNF326	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	ZNF326 is a member of the DBIRD complex that regulates splicing by binding to PolII in an RNA-independant manner (PMID:22446626).	IPR007071;	284695	zinc finger protein 326 [Source:HGNC Symbol;Acc:HGNC:14104]	None	DBD and Full	not tested	None	None	b	No	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:9809746;10798446	No	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000340796#ENSG00000162664#ENST00000340281#C2H2 ZF Containing Proteins#AKAP95$#ENSP00000355318#ENSG00000162664#ENST00000361911#C2H2 ZF Containing Proteins#$#ENSP00000359476#ENSG00000162664#ENST00000370447#C2H2 ZF Containing Proteins#AKAP95	FALSE
591	ENSG00000181894	ZNF329	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	79673	zinc finger protein 329 [Source:HGNC Symbol;Acc:HGNC:14209]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000350773#ENSG00000181894#ENST00000358067#C2H2 ZF Containing Proteins#$#ENSP00000470008#ENSG00000181894#ENST00000598312#C2H2 ZF Containing Proteins#$#ENSP00000471614#ENSG00000181894#ENST00000601887#C2H2 ZF Containing Proteins#$#ENSP00000470323#ENSG00000181894#ENST00000597186#C2H2 ZF Containing Proteins#	FALSE
592	ENSG00000130844	ZNF331	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	55422	zinc finger protein 331 [Source:HGNC Symbol;Acc:HGNC:15489]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	None	$#ENSP00000253144#ENSG00000130844#ENST00000253144#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393336#ENSG00000130844#ENST00000411977#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423675#ENSG00000130844#ENST00000502248#C2H2 ZF Containing Proteins#KRAB$#ENSP00000422586#ENSG00000130844#ENST00000502616#C2H2 ZF Containing Proteins#KRAB$#ENSP00000425517#ENSG00000130844#ENST00000504493#C2H2 ZF Containing Proteins#KRAB$#ENSP00000424929#ENSG00000130844#ENST00000505426#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421014#ENSG00000130844#ENST00000511154#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421728#ENSG00000130844#ENST00000512387#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423156#ENSG00000130844#ENST00000513999#C2H2 ZF Containing Proteins#KRAB$#ENSP00000422471#ENSG00000130844#ENST00000514022#C2H2 ZF Containing Proteins#KRAB$#ENSP00000423263#ENSG00000130844#ENST00000509047#C2H2 ZF Containing Proteins#KRAB$#ENSP00000426458#ENSG00000130844#ENST00000513265#C2H2 ZF Containing Proteins#KRAB	TRUE
593	ENSG00000160961	ZNF333	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003656;IPR007087;IPR015880	84449	zinc finger protein 333 [Source:HGNC Symbol;Acc:HGNC:15624]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	None	$#ENSP00000292530#ENSG00000160961#ENST00000292530#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438130#ENSG00000160961#ENST00000540689#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472026#ENSG00000160961#ENST00000601134#C2H2 ZF Containing Proteins#KRAB	TRUE
594	ENSG00000198185	ZNF334	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	55713	zinc finger protein 334 [Source:HGNC Symbol;Acc:HGNC:15806]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000198185#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000255129#ENSG00000198185#ENST00000347606#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473194#ENSG00000198185#ENST00000593880#C2H2 ZF Containing Proteins#$#ENSP00000402582#ENSG00000198185#ENST00000457685#C2H2 ZF Containing Proteins#$#ENSP00000473164#ENSG00000198185#ENST00000596323#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485779#ENSG00000198185#ENST00000625284#C2H2 ZF Containing Proteins#KRAB	TRUE
595	ENSG00000198026	ZNF335	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	IPR007087;IPR015880	63925	zinc finger protein 335 [Source:HGNC Symbol;Acc:HGNC:15807]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000325326#ENSG00000198026#ENST00000322927#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
596	ENSG00000130684	ZNF337	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	26152	zinc finger protein 337 [Source:HGNC Symbol;Acc:HGNC:15809]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	None	$#ENSP00000252979#ENSG00000130684#ENST00000252979#C2H2 ZF Containing Proteins#KRAB$#ENSP00000365619#ENSG00000130684#ENST00000376436#C2H2 ZF Containing Proteins#KRAB	TRUE
597	ENSG00000189180	ZNF33A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7581	zinc finger protein 33A [Source:HGNC Symbol;Acc:HGNC:13096]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000189180#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:8464732	$#ENSP00000402467#ENSG00000189180#ENST00000432900#C2H2 ZF Containing Proteins#KRAB$#ENSP00000387713#ENSG00000189180#ENST00000458705#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485869#ENSG00000189180#ENST00000628825#C2H2 ZF Containing Proteins#KRAB	TRUE
598	ENSG00000196693	ZNF33B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7582	zinc finger protein 33B [Source:HGNC Symbol;Acc:HGNC:13097]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000196693#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000352444#ENSG00000196693#ENST00000359467#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484085#ENSG00000196693#ENST00000462075#C2H2 ZF Containing Proteins#$#ENSP00000480979#ENSG00000196693#ENST00000465206#C2H2 ZF Containing Proteins#KRAB	TRUE
599	ENSG00000196378	ZNF34	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	80778	zinc finger protein 34 [Source:HGNC Symbol;Acc:HGNC:13098]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000341528#ENSG00000196378#ENST00000343459#C2H2 ZF Containing Proteins#KRAB$#ENSP00000396894#ENSG00000196378#ENST00000429371#C2H2 ZF Containing Proteins#KRAB$#ENSP00000434049#ENSG00000196378#ENST00000534337#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437056#ENSG00000196378#ENST00000534445#C2H2 ZF Containing Proteins#KRAB	TRUE
600	ENSG00000131061	ZNF341	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR007087;IPR015880	84905	zinc finger protein 341 [Source:HGNC Symbol;Acc:HGNC:15992]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000131061#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000344308#ENSG00000131061#ENST00000342427#C2H2 ZF Containing Proteins#$#ENSP00000364346#ENSG00000131061#ENST00000375200#C2H2 ZF Containing Proteins#	FALSE
601	ENSG00000088876	ZNF343	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	79175	zinc finger protein 343 [Source:HGNC Symbol;Acc:HGNC:16017]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000370652#ENSG00000088876#ENST00000381253#C2H2 ZF Containing Proteins#KRAB$#ENSP00000399682#ENSG00000088876#ENST00000445484#C2H2 ZF Containing Proteins#KRAB$#ENSP00000278772#ENSG00000088876#ENST00000278772#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000416488#ENSG00000088876#ENST00000421216#C2H2 ZF Containing Proteins#KRAB	TRUE
602	ENSG00000251247	ZNF345	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	25850	Zinc finger protein 345 [Source:HGNC Symbol;Acc:HGNC:16367]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000251247#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000431216#ENSG00000251247#ENST00000420450#C2H2 ZF Containing Proteins#$#ENSP00000431202#ENSG00000251247#ENST00000529555#C2H2 ZF Containing Proteins#$#ENSP00000465431#ENSG00000251247#ENST00000589046#C2H2 ZF Containing Proteins#$#ENSP00000467611#ENSG00000251247#ENST00000526123#C2H2 ZF Containing Proteins#$#ENSP00000431289#ENSG00000251247#ENST00000532141#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000465851#ENSG00000251247#ENST00000585396#C2H2 ZF Containing Proteins#$#ENSP00000477522#ENSG00000251247#ENST00000614069#C2H2 ZF Containing Proteins#	FALSE
603	ENSG00000113761	ZNF346	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds dsDNA with low affinity and no discernible specificity (PMID: 24521053).	IPR003604;IPR007087;IPR015880;	23567	zinc finger protein 346 [Source:HGNC Symbol;Acc:HGNC:16403]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000350869#ENSG00000113761#ENST00000358149#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000424495#ENSG00000113761#ENST00000503039#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000421212#ENSG00000113761#ENST00000503425#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000423515#ENSG00000113761#ENST00000506693#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000421089#ENSG00000113761#ENST00000512315#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-met	FALSE
604	ENSG00000197937	ZNF347	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	84671	zinc finger protein 347 [Source:HGNC Symbol;Acc:HGNC:16447]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	None	$#ENSP00000334146#ENSG00000197937#ENST00000334197#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405218#ENSG00000197937#ENST00000452676#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469338#ENSG00000197937#ENST00000597183#C2H2 ZF Containing Proteins#$#ENSP00000471712#ENSG00000197937#ENST00000601469#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470499#ENSG00000197937#ENST00000595967#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471825#ENSG00000197937#ENST00000599096#C2H2 ZF Containing Proteins#KRAB	TRUE
605	ENSG00000169981	ZNF35	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	7584	zinc finger protein 35 [Source:HGNC Symbol;Acc:HGNC:13099]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000169981#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:1572646	$#ENSP00000296092#ENSG00000169981#ENST00000296092#C2H2 ZF Containing Proteins#$#ENSP00000379368#ENSG00000169981#ENST00000396056#C2H2 ZF Containing Proteins#$#ENSP00000404354#ENSG00000169981#ENST00000415571#C2H2 ZF Containing Proteins#$#ENSP00000401311#ENSG00000169981#ENST00000453164#C2H2 ZF Containing Proteins#	FALSE
606	ENSG00000256683	ZNF350	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	59348	zinc finger protein 350 [Source:HGNC Symbol;Acc:HGNC:16656]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000256683#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11090615	$#ENSP00000243644#ENSG00000256683#ENST00000243644#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472104#ENSG00000256683#ENST00000593596#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469594#ENSG00000256683#ENST00000594929#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470930#ENSG00000256683#ENST00000601430#C2H2 ZF Containing Proteins#	TRUE
607	ENSG00000169131	ZNF354A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	6940	zinc finger protein 354A [Source:HGNC Symbol;Acc:HGNC:11628]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: non-sequence-specific_Transactivation_PMIDS:8183940;9346939	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000169131#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000337122#ENSG00000169131#ENST00000335815#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429675#ENSG00000169131#ENST00000520331#C2H2 ZF Containing Proteins#KRAB	TRUE
608	ENSG00000178338	ZNF354B	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	117608	zinc finger protein 354B [Source:HGNC Symbol;Acc:HGNC:17197]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000178338#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000327143#ENSG00000178338#ENST00000322434#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429827#ENSG00000178338#ENST00000520377#C2H2 ZF Containing Proteins#KRAB	TRUE
609	ENSG00000177932	ZNF354C	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001909;IPR007087;IPR015880;	30832	zinc finger protein 354C [Source:HGNC Symbol;Acc:HGNC:16736]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000177932#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000324064#ENSG00000177932#ENST00000315475#C2H2 ZF Containing Proteins#KRAB	TRUE
610	ENSG00000168122	ZNF355P	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	None	None	None	Putative zinc finger protein 355P	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000168122#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000168122##Other#	FALSE
611	ENSG00000198816	ZNF358	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	140467	zinc finger protein 358 [Source:HGNC Symbol;Acc:HGNC:16838]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000472305#ENSG00000198816#ENST00000597229#C2H2 ZF Containing Proteins#$#ENSP00000472777#ENSG00000198816#ENST00000596712#C2H2 ZF Containing Proteins#	FALSE
612	ENSG00000160094	ZNF362	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	149076	zinc finger protein 362 [Source:HGNC Symbol;Acc:HGNC:18079]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000362527#ENSG00000160094#ENST00000373428#C2H2 ZF Containing Proteins#$#ENSP00000438354#ENSG00000160094#ENST00000483388#C2H2 ZF Containing Proteins#$#ENSP00000446335#ENSG00000160094#ENST00000539719#C2H2 ZF Containing Proteins#	FALSE
613	ENSG00000138311	ZNF365	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Also contains a Ku C terminal like domain that is thought to be involved in DNA-damage repair pathways.	None	22891	zinc finger protein 365 [Source:HGNC Symbol;Acc:HGNC:18194]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000378670#ENSG00000138311#ENST00000395249#C2H2 ZF Containing Proteins#$#ENSP00000378672#ENSG00000138311#ENST00000395251#C2H2 ZF Containing Proteins#$#ENSP00000378674#ENSG00000138311#ENST00000395254#C2H2 ZF Containing Proteins#$#ENSP00000378675#ENSG00000138311#ENST00000395255#C2H2 ZF Containing Proteins#Ku_PK_bind$#ENSP00000387091#ENSG00000138311#ENST00000410046#C2H2 ZF Containing Proteins#	FALSE
614	ENSG00000178175	ZNF366	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	This protein has been shown to complex with and function as a corepressor for ESR1 (PMID: 17085477) and glucocorticoid receptor (PMID: 23440419). It has a nice set of znfs and could thus well bind DNA independently.	IPR007087;IPR015880	167465	zinc finger protein 366 [Source:HGNC Symbol;Acc:HGNC:18316]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000313158#ENSG00000178175#ENST00000318442#C2H2 ZF Containing Proteins#$#ENSP00000391333#ENSG00000178175#ENST00000414109#C2H2 ZF Containing Proteins#	FALSE
615	ENSG00000165244	ZNF367	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Virtually nothing is known for this protein except that it has two znfC2H2 domains next to each other	IPR007087;IPR015880	195828	zinc finger protein 367 [Source:HGNC Symbol;Acc:HGNC:18320]	None	Full	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000165244#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15344908	$#ENSP00000364405#ENSG00000165244#ENST00000375256#C2H2 ZF Containing Proteins#	FALSE
616	ENSG00000075407	ZNF37A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7587	zinc finger protein 37A [Source:HGNC Symbol;Acc:HGNC:13102]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000075407#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:8464732	$#ENSP00000329141#ENSG00000075407#ENST00000351773#C2H2 ZF Containing Proteins#KRAB$#ENSP00000354377#ENSG00000075407#ENST00000361085#C2H2 ZF Containing Proteins#KRAB$#ENSP00000490669#ENSG00000075407#ENST00000638053#C2H2 ZF Containing Proteins#KRAB	TRUE
617	ENSG00000161298	ZNF382	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	84911	zinc finger protein 382 [Source:HGNC Symbol;Acc:HGNC:17409]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000161298#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000292928#ENSG00000161298#ENST00000292928#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389722#ENSG00000161298#ENST00000423582#C2H2 ZF Containing Proteins#$#ENSP00000410113#ENSG00000161298#ENST00000435416#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407593#ENSG00000161298#ENST00000439428#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467675#ENSG00000161298#ENST00000460670#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465485#ENSG00000161298#ENST00000590785#C2H2 ZF Containing Proteins#	TRUE
618	ENSG00000188283	ZNF383	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	163087	zinc finger protein 383 [Source:HGNC Symbol;Acc:HGNC:18609]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000188283#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000340132#ENSG00000188283#ENST00000352998#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464871#ENSG00000188283#ENST00000589413#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465246#ENSG00000188283#ENST00000588371#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466101#ENSG00000188283#ENST00000590503#C2H2 ZF Containing Proteins#KRAB	TRUE
619	ENSG00000126746	ZNF384	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	171017	zinc finger protein 384 [Source:HGNC Symbol;Acc:HGNC:11955]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000348018#ENSG00000126746#ENST00000355772#C2H2 ZF Containing Proteins#$#ENSP00000321650#ENSG00000126746#ENST00000319770#C2H2 ZF Containing Proteins#$#ENSP00000380019#ENSG00000126746#ENST00000396801#C2H2 ZF Containing Proteins#$#ENSP00000439736#ENSG00000126746#ENST00000540915#C2H2 ZF Containing Proteins#$#ENSP00000412911#ENSG00000126746#ENST00000436774#C2H2 ZF Containing Proteins#$#ENSP00000437488#ENSG00000126746#ENST00000535485#C2H2 ZF Containing Proteins#$#ENSP00000473311#ENSG00000126746#ENST00000545946#C2H2 ZF Containing Proteins#Med15, Pex14_N	FALSE
620	ENSG00000161642	ZNF385A	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003604;IPR007087;IPR015880;	25946	zinc finger protein 385A [Source:HGNC Symbol;Acc:HGNC:17521]	None	Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000338927#ENSG00000161642#ENST00000338010#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000377849#ENSG00000161642#ENST00000394313#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000446913#ENSG00000161642#ENST00000546970#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000447162#ENSG00000161642#ENST00000551771#C2H2 ZF Containing Proteins#$#ENSP00000293385#ENSG00000161642#ENST00000352268#C2H2 ZF Containing Proteins#	FALSE
621	ENSG00000144331	ZNF385B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003604;IPR007087;IPR015880;	151126	zinc finger protein 385B [Source:HGNC Symbol;Acc:HGNC:26332]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000386845#ENSG00000144331#ENST00000410066#C2H2 ZF Containing Proteins#AKAP95, zf-C2H2_2, zf-C2H2_jaz, zf-DBF, zf-U1, zf-$#ENSP00000386379#ENSG00000144331#ENST00000409343#C2H2 ZF Containing Proteins#$#ENSP00000400232#ENSG00000144331#ENST00000438871#C2H2 ZF Containing Proteins#$#ENSP00000409978#ENSG00000144331#ENST00000451732#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-met	FALSE
622	ENSG00000187595	ZNF385C	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003604;IPR007087;IPR015880;	201181	zinc finger protein 385C [Source:HGNC Symbol;Acc:HGNC:33722]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000411514#ENSG00000187595#ENST00000436535#C2H2 ZF Containing Proteins#zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000480744#ENSG00000187595#ENST00000618554#C2H2 ZF Containing Proteins#	FALSE
623	ENSG00000151789	ZNF385D	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003604;IPR007087;IPR015880;	79750	zinc finger protein 385D [Source:HGNC Symbol;Acc:HGNC:26191]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000281523#ENSG00000151789#ENST00000281523#C2H2 ZF Containing Proteins#	FALSE
624	ENSG00000124613	ZNF391	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	346157	zinc finger protein 391 [Source:HGNC Symbol;Acc:HGNC:18779]	None	Full	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000124613#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000244576#ENSG00000124613#ENST00000244576#C2H2 ZF Containing Proteins#$#ENSP00000419498#ENSG00000124613#ENST00000461521#C2H2 ZF Containing Proteins#	FALSE
625	ENSG00000160908	ZNF394	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	84124	zinc finger protein 394 [Source:HGNC Symbol;Acc:HGNC:18832]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000160908#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000337363#ENSG00000160908#ENST00000337673#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000409565#ENSG00000160908#ENST00000426306#C2H2 ZF Containing Proteins#SCAN	TRUE
626	ENSG00000186918	ZNF395	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Contains a single ZF (string matching on Uniprot) that is not identified using Pfam HMM thresholds. Shown to bind a short DNA sequence (GCCGGCG) by EMSA and DNase I footprinting (PMID:14625278).	IPR007087;	55893	zinc finger protein 395 [Source:HGNC Symbol;Acc:HGNC:18737]	None	DBD and Full	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000340494#ENSG00000186918#ENST00000344423#C2H2 ZF Containing Proteins#DUF4772, FOXP-CC$#ENSP00000428452#ENSG00000186918#ENST00000523095#C2H2 ZF Containing Proteins#DUF4772, FOXP-CC$#ENSP00000429640#ENSG00000186918#ENST00000523202#C2H2 ZF Containing Proteins#DUF4772, FOXP-CC$#ENSP00000429649#ENSG00000186918#ENST00000517459#C2H2 ZF Containing Proteins#DUF4772$#ENSP00000427934#ENSG00000186918#ENST00000521912#C2H2 ZF Containing Proteins#DUF4772$#ENSP00000429823#ENSG00000186918#ENST00000522795#C2H2 ZF Containing Proteins#DUF4772	FALSE
627	ENSG00000186496	ZNF396	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	252884	zinc finger protein 396 [Source:HGNC Symbol;Acc:HGNC:18824]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000186496#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000302310#ENSG00000186496#ENST00000306346#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467275#ENSG00000186496#ENST00000586687#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466500#ENSG00000186496#ENST00000589332#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468381#ENSG00000186496#ENST00000585522#C2H2 ZF Containing Proteins#SCAN	FALSE
628	ENSG00000186812	ZNF397	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and that it binds on centromeric regions PMID: 18369653	IPR003309;IPR007087;IPR008916;IPR015880	84307	zinc finger protein 397 [Source:HGNC Symbol;Acc:HGNC:18818]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000186812#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000261333#ENSG00000186812#ENST00000261333#C2H2 ZF Containing Proteins#SCAN$#ENSP00000331577#ENSG00000186812#ENST00000330501#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466317#ENSG00000186812#ENST00000591206#C2H2 ZF Containing Proteins#SCAN$#ENSP00000464808#ENSG00000186812#ENST00000588119#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468413#ENSG00000186812#ENST00000592264#C2H2 ZF Containing Proteins#SCAN	FALSE
629	ENSG00000197024	ZNF398	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;IPR022137	57541	zinc finger protein 398 [Source:HGNC Symbol;Acc:HGNC:18373]	None	Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000389972#ENSG00000197024#ENST00000426851#C2H2 ZF Containing Proteins#$#ENSP00000420418#ENSG00000197024#ENST00000475153#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000419391#ENSG00000197024#ENST00000491174#C2H2 ZF Containing Proteins#$#ENSP00000418564#ENSG00000197024#ENST00000483892#C2H2 ZF Containing Proteins#	TRUE
630	ENSG00000176222	ZNF404	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	342908	zinc finger protein 404 [Source:HGNC Symbol;Acc:HGNC:19417]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000319479#ENSG00000176222#ENST00000324394#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466051#ENSG00000176222#ENST00000587539#C2H2 ZF Containing Proteins#KRAB	TRUE
631	ENSG00000215421	ZNF407	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Protein has a decent cassette of znfC2H2 domains; a study links it in regulation of glucose intake receptor GLUT4 (PMID: 25596527).	IPR003604;IPR007087;IPR015880;	55628	zinc finger protein 407 [Source:HGNC Symbol;Acc:HGNC:19904]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000299687#ENSG00000215421#ENST00000299687#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2, zf-H2C2_5, zf-met$#ENSP00000310359#ENSG00000215421#ENST00000309902#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-H2C2_2, zf-H2C2_5, zf-met$#ENSP00000463270#ENSG00000215421#ENST00000577538#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2, zf-H2C2_5, zf-met$#ENSP00000481798#ENSG00000215421#ENST00000584235#C2H2 ZF Containing Proteins#	FALSE
632	ENSG00000175213	ZNF408	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	79797	zinc finger protein 408 [Source:HGNC Symbol;Acc:HGNC:20041]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000309606#ENSG00000175213#ENST00000311764#C2H2 ZF Containing Proteins#	FALSE
633	ENSG00000147124	ZNF41	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7592	zinc finger protein 41 [Source:HGNC Symbol;Acc:HGNC:13107]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000147124#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000315173#ENSG00000147124#ENST00000313116#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366265#ENSG00000147124#ENST00000377065#C2H2 ZF Containing Proteins#KRAB$#ENSP00000390385#ENSG00000147124#ENST00000432977#C2H2 ZF Containing Proteins#KRAB	TRUE
634	ENSG00000119725	ZNF410	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	57862	zinc finger protein 410 [Source:HGNC Symbol;Acc:HGNC:20144]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000323293#ENSG00000119725#ENST00000324593#C2H2 ZF Containing Proteins#$#ENSP00000407130#ENSG00000119725#ENST00000442160#C2H2 ZF Containing Proteins#$#ENSP00000451763#ENSG00000119725#ENST00000555044#C2H2 ZF Containing Proteins#$#ENSP00000442228#ENSG00000119725#ENST00000540593#C2H2 ZF Containing Proteins#$#ENSP00000451116#ENSG00000119725#ENST00000554797#C2H2 ZF Containing Proteins#$#ENSP00000451073#ENSG00000119725#ENST00000556797#C2H2 ZF Containing Proteins#$#ENSP00000451748#ENSG00000119725#ENST00000554316#C2H2 ZF Containing Proteins#$#ENSP00000451620#ENSG00000119725#ENST00000557214#C2H2 ZF Containing Proteins#	FALSE
635	ENSG00000133250	ZNF414	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Its on the low end of  confidence that its a TF; since most of the domains are variants of C2H2; but its more likely than not since they are in a row.	IPR007087;IPR015880	84330	zinc finger protein 414 [Source:HGNC Symbol;Acc:HGNC:20630]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Tim Hughes	Yes	None	$#ENSP00000255616#ENSG00000133250#ENST00000255616#C2H2 ZF Containing Proteins#$#ENSP00000377504#ENSG00000133250#ENST00000393927#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000471378#ENSG00000133250#ENST00000596772#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000473079#ENSG00000133250#ENST00000593661#C2H2 ZF Containing Proteins#zf-C2H2_8$#ENSP00000471863#ENSG00000133250#ENST00000594748#C2H2 ZF Containing Proteins#zf-C2H2_8	FALSE
636	ENSG00000170954	ZNF415	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR003656;IPR007087;IPR015880	55786	Zinc finger protein 415 [Source:HGNC Symbol;Acc:HGNC:20636]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000170954#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000243643#ENSG00000170954#ENST00000243643#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472911#ENSG00000170954#ENST00000601493#C2H2 ZF Containing Proteins#$#ENSP00000472584#ENSG00000170954#ENST00000594011#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472516#ENSG00000170954#ENST00000595193#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468917#ENSG00000170954#ENST00000597503#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473008#ENSG00000170954#ENST00000596051#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471167#ENSG00000170954#ENST00000599261#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469483#ENSG00000170954#ENST00000600574#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470410#ENSG00000170954#ENST00000601110#C2H2 ZF Containing Proteins#KRAB	FALSE
637	ENSG00000083817	ZNF416	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001909;IPR007087;IPR015880;	55659	zinc finger protein 416 [Source:HGNC Symbol;Acc:HGNC:20645]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000196489#ENSG00000083817#ENST00000196489#C2H2 ZF Containing Proteins#KRAB	TRUE
638	ENSG00000173480	ZNF417	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147687	zinc finger protein 417 [Source:HGNC Symbol;Acc:HGNC:20646]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000311319#ENSG00000173480#ENST00000312026#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000472272#ENSG00000173480#ENST00000595559#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000471471#ENSG00000173480#ENST00000598629#C2H2 ZF Containing Proteins#$#ENSP00000472352#ENSG00000173480#ENST00000594396#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471325#ENSG00000173480#ENST00000598526#C2H2 ZF Containing Proteins#	TRUE
639	ENSG00000196724	ZNF418	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147686	zinc finger protein 418 [Source:HGNC Symbol;Acc:HGNC:20647]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000196724#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000379451#ENSG00000196724#ENST00000396147#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000471652#ENSG00000196724#ENST00000595830#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000483763#ENSG00000196724#ENST00000616958#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000407039#ENSG00000196724#ENST00000425570#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000468968#ENSG00000196724#ENST00000599852#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
640	ENSG00000105136	ZNF419	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	79744	zinc finger protein 419 [Source:HGNC Symbol;Acc:HGNC:20648]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000105136#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000221735#ENSG00000105136#ENST00000221735#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000388864#ENSG00000105136#ENST00000424930#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000299860#ENSG00000105136#ENST00000347466#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000392129#ENSG00000105136#ENST00000415379#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000390916#ENSG00000105136#ENST00000426954#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000414709#ENSG00000105136#ENST00000442920#C2H2 ZF Containing Proteins#FAM178, KRAB$#ENSP00000427723#ENSG00000105136#ENST00000518999#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429504#ENSG00000105136#ENST00000523138#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428181#ENSG00000105136#ENST00000523882#C2H2 ZF Containing Proteins#KRAB	TRUE
641	ENSG00000197050	ZNF420	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	147923	zinc finger protein 420 [Source:HGNC Symbol;Acc:HGNC:20649]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000197050#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000338770#ENSG00000197050#ENST00000337995#C2H2 ZF Containing Proteins#KRAB$#ENSP00000306102#ENSG00000197050#ENST00000304239#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468736#ENSG00000197050#ENST00000585862#C2H2 ZF Containing Proteins#	TRUE
642	ENSG00000102935	ZNF423	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	23090	zinc finger protein 423 [Source:HGNC Symbol;Acc:HGNC:16762]	None	Full	not tested	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9151733;9774661	No	2a1, Lower confidence direct evidence	Yimeng Yin	Tim Hughes	Yes	None	$#ENSP00000262383#ENSG00000102935#ENST00000262383#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000457664#ENSG00000102935#ENST00000562520#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000455061#ENSG00000102935#ENST00000567169#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000442321#ENSG00000102935#ENST00000535559#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000479288#ENSG00000102935#ENST00000568094#C2H2 ZF Containing Proteins#C1_4, Zn-ribbon_8, zf-C2H2_4	FALSE
643	ENSG00000204947	ZNF425	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	155054	zinc finger protein 425 [Source:HGNC Symbol;Acc:HGNC:20690]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000367300#ENSG00000204947#ENST00000378061#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420379#ENSG00000204947#ENST00000483014#C2H2 ZF Containing Proteins#KRAB	TRUE
644	ENSG00000130818	ZNF426	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR003656;IPR007087;IPR015880	79088	zinc finger protein 426 [Source:HGNC Symbol;Acc:HGNC:20725]	None	DBD and Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000253115#ENSG00000130818#ENST00000253115#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439017#ENSG00000130818#ENST00000535489#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468100#ENSG00000130818#ENST00000593003#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466469#ENSG00000130818#ENST00000589289#C2H2 ZF Containing Proteins#KRAB	TRUE
645	ENSG00000131116	ZNF428	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;	126299	zinc finger protein 428 [Source:HGNC Symbol;Acc:HGNC:20804]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000300811#ENSG00000131116#ENST00000300811#C2H2 ZF Containing Proteins#$#ENSP00000469484#ENSG00000131116#ENST00000598676#C2H2 ZF Containing Proteins#	FALSE
646	ENSG00000197013	ZNF429	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	353088	zinc finger protein 429 [Source:HGNC Symbol;Acc:HGNC:20817]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000197013#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000469739#ENSG00000197013#ENST00000594385#C2H2 ZF Containing Proteins#$#ENSP00000470300#ENSG00000197013#ENST00000597078#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351280#ENSG00000197013#ENST00000358491#C2H2 ZF Containing Proteins#KRAB$#ENSP00000479286#ENSG00000197013#ENST00000618549#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
647	ENSG00000198521	ZNF43	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7594	zinc finger protein 43 [Source:HGNC Symbol;Acc:HGNC:13109]	None	Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	None	$##ENSG00000198521##C2H2 ZF Containing Proteins#	TRUE
648	ENSG00000118620	ZNF430	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	80264	zinc finger protein 430 [Source:HGNC Symbol;Acc:HGNC:20808]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Pratyush Das	Yes	None	$#ENSP00000261560#ENSG00000118620#ENST00000261560#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469148#ENSG00000118620#ENST00000595401#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473069#ENSG00000118620#ENST00000594110#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469787#ENSG00000118620#ENST00000597922#C2H2 ZF Containing Proteins#	TRUE
649	ENSG00000196705	ZNF431	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	170959	zinc finger protein 431 [Source:HGNC Symbol;Acc:HGNC:20809]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000196705#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000308578#ENSG00000196705#ENST00000311048#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469460#ENSG00000196705#ENST00000594425#C2H2 ZF Containing Proteins#	TRUE
650	ENSG00000256087	ZNF432	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	9668	zinc finger protein 614 [Source:HGNC Symbol;Acc:HGNC:24722]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000256087#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000221315#ENSG00000256087#ENST00000221315#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470488#ENSG00000256087#ENST00000594154#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470341#ENSG00000256087#ENST00000597273#C2H2 ZF Containing Proteins#KRAB	TRUE
651	ENSG00000197647	ZNF433	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	163059	zinc finger protein 433 [Source:HGNC Symbol;Acc:HGNC:20811]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000393416#ENSG00000197647#ENST00000419886#C2H2 ZF Containing Proteins#$#ENSP00000447951#ENSG00000197647#ENST00000478765#C2H2 ZF Containing Proteins#KRAB$#ENSP00000339767#ENSG00000197647#ENST00000344980#C2H2 ZF Containing Proteins#KRAB$#ENSP00000448099#ENSG00000197647#ENST00000550507#C2H2 ZF Containing Proteins#KRAB$#ENSP00000448806#ENSG00000197647#ENST00000547560#C2H2 ZF Containing Proteins#$#ENSP00000447205#ENSG00000197647#ENST00000550745#C2H2 ZF Containing Proteins#KRAB	TRUE
652	ENSG00000125945	ZNF436	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	80818	zinc finger protein 436 [Source:HGNC Symbol;Acc:HGNC:20814]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000125945#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000313582#ENSG00000125945#ENST00000314011#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363736#ENSG00000125945#ENST00000374608#C2H2 ZF Containing Proteins#KRAB	TRUE
653	ENSG00000183621	ZNF438	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has two znfC2H2 domains and that it represses transcription in a reporter assay PMID: 17669267	IPR007087;IPR015880	220929	zinc finger protein 438 [Source:HGNC Symbol;Acc:HGNC:21029]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000333571#ENSG00000183621#ENST00000331737#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000354663#ENSG00000183621#ENST00000361310#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000364460#ENSG00000183621#ENST00000375311#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000445461#ENSG00000183621#ENST00000538351#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
654	ENSG00000171291	ZNF439	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	90594	zinc finger protein 439 [Source:HGNC Symbol;Acc:HGNC:20873]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000305077#ENSG00000171291#ENST00000304030#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395632#ENSG00000171291#ENST00000455282#C2H2 ZF Containing Proteins#$#ENSP00000388234#ENSG00000171291#ENST00000442091#C2H2 ZF Containing Proteins#KRAB	TRUE
655	ENSG00000197857	ZNF44	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	51710	zinc finger protein 44 [Source:HGNC Symbol;Acc:HGNC:13110]	None	Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000347910#ENSG00000197857#ENST00000355684#C2H2 ZF Containing Proteins#KRAB$#ENSP00000348419#ENSG00000197857#ENST00000356109#C2H2 ZF Containing Proteins#KRAB	TRUE
656	ENSG00000171295	ZNF440	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	126070	zinc finger protein 440 [Source:HGNC Symbol;Acc:HGNC:20874]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000305373#ENSG00000171295#ENST00000304060#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000411974#ENSG00000171295#ENST00000414255#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393489#ENSG00000171295#ENST00000427505#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404425#ENSG00000171295#ENST00000457526#C2H2 ZF Containing Proteins#	TRUE
657	ENSG00000197044	ZNF441	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	126068	zinc finger protein 441 [Source:HGNC Symbol;Acc:HGNC:20875]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000350576#ENSG00000197044#ENST00000357901#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2	TRUE
658	ENSG00000198342	ZNF442	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	79973	zinc finger protein 442 [Source:HGNC Symbol;Acc:HGNC:20877]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000242804#ENSG00000198342#ENST00000242804#C2H2 ZF Containing Proteins#KRAB$#ENSP00000388634#ENSG00000198342#ENST00000438182#C2H2 ZF Containing Proteins#$#ENSP00000404935#ENSG00000198342#ENST00000424168#C2H2 ZF Containing Proteins#$#ENSP00000440162#ENSG00000198342#ENST00000545749#C2H2 ZF Containing Proteins#KRAB	TRUE
659	ENSG00000180855	ZNF443	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	10224	zinc finger protein 443 [Source:HGNC Symbol;Acc:HGNC:20878]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000301547#ENSG00000180855#ENST00000301547#C2H2 ZF Containing Proteins#KRAB	TRUE
660	ENSG00000167685	ZNF444	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	55311	zinc finger protein 444 [Source:HGNC Symbol;Acc:HGNC:16052]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000167685#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000338860#ENSG00000167685#ENST00000337080#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468069#ENSG00000167685#ENST00000592949#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465171#ENSG00000167685#ENST00000587467#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466287#ENSG00000167685#ENST00000588358#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468762#ENSG00000167685#ENST00000591564#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465070#ENSG00000167685#ENST00000593100#C2H2 ZF Containing Proteins#SCAN	FALSE
661	ENSG00000185219	ZNF445	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	353274	zinc finger protein 445 [Source:HGNC Symbol;Acc:HGNC:21018]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000185219#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000379387#ENSG00000185219#ENST00000396077#C2H2 ZF Containing Proteins#KRAB, SCAN, zf-C2H2_4, zf-H2C2_2$#ENSP00000413073#ENSG00000185219#ENST00000425708#C2H2 ZF Containing Proteins#KRAB, SCAN, zf-C2H2_4, zf-H2C2_2$#ENSP00000483454#ENSG00000185219#ENST00000617032#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
662	ENSG00000083838	ZNF446	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains three znfC2H2 domains and represses transcription when expressed as GAL4 fusion (PMID:15936718).	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	55663	zinc finger protein 446 [Source:HGNC Symbol;Acc:HGNC:21036]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000083838#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000472802#ENSG00000083838#ENST00000594369#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000478778#ENSG00000083838#ENST00000610298#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000484676#ENSG00000083838#ENST00000622313#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470963#ENSG00000083838#ENST00000600013#C2H2 ZF Containing Proteins#SCAN	TRUE
663	ENSG00000173275	ZNF449	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	203523	zinc finger protein 449 [Source:HGNC Symbol;Acc:HGNC:21039]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000173275#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000339585#ENSG00000173275#ENST00000339249#C2H2 ZF Containing Proteins#SCAN$#ENSP00000359797#ENSG00000173275#ENST00000370761#C2H2 ZF Containing Proteins#SCAN	FALSE
664	ENSG00000124459	ZNF45	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7596	zinc finger protein 45 [Source:HGNC Symbol;Acc:HGNC:13111]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000124459#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9570955	$#ENSP00000468579#ENSG00000124459#ENST00000589703#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000481895#ENSG00000124459#ENST00000615985#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000269973#ENSG00000124459#ENST00000269973#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467551#ENSG00000124459#ENST00000588140#C2H2 ZF Containing Proteins#	TRUE
665	ENSG00000112200	ZNF451	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880;IPR021623;	26036	zinc finger protein 451 [Source:HGNC Symbol;Acc:HGNC:21091]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000112200#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000350083#ENSG00000112200#ENST00000357489#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000359740#ENSG00000112200#ENST00000370706#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000421645#ENSG00000112200#ENST00000491832#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000359736#ENSG00000112200#ENST00000370702#C2H2 ZF Containing Proteins#$#ENSP00000359742#ENSG00000112200#ENST00000370708#C2H2 ZF Containing Proteins#LAP2alpha$#ENSP00000359744#ENSG00000112200#ENST00000370710#C2H2 ZF Containing Proteins#	FALSE
666	ENSG00000178187	ZNF454	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	285676	zinc finger protein 454 [Source:HGNC Symbol;Acc:HGNC:21200]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000178187#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000326249#ENSG00000178187#ENST00000320129#C2H2 ZF Containing Proteins#KRAB$#ENSP00000430354#ENSG00000178187#ENST00000519564#C2H2 ZF Containing Proteins#KRAB	TRUE
667	ENSG00000197714	ZNF460	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	10794	zinc finger protein 460 [Source:HGNC Symbol;Acc:HGNC:21628]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000353491#ENSG00000197714#ENST00000360338#C2H2 ZF Containing Proteins#KRAB$#ENSP00000446167#ENSG00000197714#ENST00000537645#C2H2 ZF Containing Proteins#$#ENSP00000471285#ENSG00000197714#ENST00000599602#C2H2 ZF Containing Proteins#	TRUE
668	ENSG00000197808	ZNF461	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Protein has a decent cassette of znfC2H2 domains and a KRAB-domain. It has been shown also to operate as a corepressor of NR5A1, where the KRAB-domain ).mediates both the interaction to NR5A1 and to HDAC2 (PMID: 16595694	IPR001909;IPR007087;IPR015880;	92283	zinc finger protein 461 [Source:HGNC Symbol;Acc:HGNC:21629]	None	DBD	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000197808#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000467931#ENSG00000197808#ENST00000588268#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000353515#ENSG00000197808#ENST00000360357#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000464914#ENSG00000197808#ENST00000592829#C2H2 ZF Containing Proteins#KRAB	TRUE
669	ENSG00000148143	ZNF462	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has many znfC2H2 like domains that are however not in tight arrays but interspersed throughout the sequence	IPR007087;IPR015880	58499	zinc finger protein 462 [Source:HGNC Symbol;Acc:HGNC:21684]	None	Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000277225#ENSG00000148143#ENST00000277225#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000405837#ENSG00000148143#ENST00000427098#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000397306#ENSG00000148143#ENST00000441147#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5$#ENSP00000363818#ENSG00000148143#ENST00000374686#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zf-H2C2_5	FALSE
670	ENSG00000181444	ZNF467	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	168544	zinc finger protein 467 [Source:HGNC Symbol;Acc:HGNC:23154]	None	Full	not tested	None	None	b	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI_PMIDS:12426389	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000304769#ENSG00000181444#ENST00000302017#C2H2 ZF Containing Proteins#$#ENSP00000418011#ENSG00000181444#ENST00000484747#C2H2 ZF Containing Proteins#	FALSE
671	ENSG00000204604	ZNF468	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	90333	zinc finger protein 468 [Source:HGNC Symbol;Acc:HGNC:33105]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000243639#ENSG00000204604#ENST00000243639#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470381#ENSG00000204604#ENST00000595646#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6, zf-H2C2_2, zf-met$#ENSP00000470717#ENSG00000204604#ENST00000601847#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469779#ENSG00000204604#ENST00000597924#C2H2 ZF Containing Proteins#KRAB	TRUE
672	ENSG00000225614	ZNF469	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	None	IPR007087;IPR015880	84627	zinc finger protein 469 [Source:HGNC Symbol;Acc:HGNC:23216]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000402343#ENSG00000225614#ENST00000437464#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000456500#ENSG00000225614#ENST00000565624#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
673	ENSG00000197016	ZNF470	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a possible role in chondrocytes (PMID: 15302581). It has a decent cassette of znfC2H2 domains and a KRAB-domain.	IPR001909;IPR007087;IPR015880;	388566	zinc finger protein 470 [Source:HGNC Symbol;Acc:HGNC:22220]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000197016#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000333223#ENSG00000197016#ENST00000330619#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375590#ENSG00000197016#ENST00000391709#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471379#ENSG00000197016#ENST00000601902#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472891#ENSG00000197016#ENST00000594953#C2H2 ZF Containing Proteins#	TRUE
674	ENSG00000196263	ZNF471	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	57573	zinc finger protein 471 [Source:HGNC Symbol;Acc:HGNC:23226]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000196263#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000309161#ENSG00000196263#ENST00000308031#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466224#ENSG00000196263#ENST00000591537#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467570#ENSG00000196263#ENST00000591759#C2H2 ZF Containing Proteins#KRAB	TRUE
675	ENSG00000142528	ZNF473	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	25888	zinc finger protein 473 [Source:HGNC Symbol;Acc:HGNC:23239]	None	DBD and Full	not tested	None	None	b	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$#ENSP00000270617#ENSG00000142528#ENST00000270617#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000375697#ENSG00000142528#ENST00000391821#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000388961#ENSG00000142528#ENST00000445728#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000471595#ENSG00000142528#ENST00000601364#C2H2 ZF Containing Proteins#KRAB	TRUE
676	ENSG00000164185	ZNF474	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;	133923	zinc finger protein 474 [Source:HGNC Symbol;Acc:HGNC:23245]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000296600#ENSG00000164185#ENST00000296600#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2HC_2$#ENSP00000422285#ENSG00000164185#ENST00000504912#C2H2 ZF Containing Proteins#$#ENSP00000424794#ENSG00000164185#ENST00000505843#C2H2 ZF Containing Proteins#	FALSE
677	ENSG00000185177	ZNF479	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	90827	zinc finger protein 479 [Source:HGNC Symbol;Acc:HGNC:23258]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000333776#ENSG00000185177#ENST00000331162#C2H2 ZF Containing Proteins#KRAB$#ENSP00000324518#ENSG00000185177#ENST00000319636#C2H2 ZF Containing Proteins#KRAB$#ENSP00000478005#ENSG00000185177#ENST00000620639#C2H2 ZF Containing Proteins#KRAB	TRUE
678	ENSG00000180035	ZNF48	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	197407	zinc finger protein 48 [Source:HGNC Symbol;Acc:HGNC:13114]	None	DBD	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000324056#ENSG00000180035#ENST00000320159#C2H2 ZF Containing Proteins#$#ENSP00000432548#ENSG00000180035#ENST00000524644#C2H2 ZF Containing Proteins#$#ENSP00000480262#ENSG00000180035#ENST00000613509#C2H2 ZF Containing Proteins#	FALSE
679	ENSG00000198464	ZNF480	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147657	zinc finger protein 480 [Source:HGNC Symbol;Acc:HGNC:23305]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000198464#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000471754#ENSG00000198464#ENST00000595962#C2H2 ZF Containing Proteins#KRAB$#ENSP00000334164#ENSG00000198464#ENST00000334564#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418618#ENSG00000198464#ENST00000490272#C2H2 ZF Containing Proteins#$#ENSP00000335670#ENSG00000198464#ENST00000335090#C2H2 ZF Containing Proteins#	TRUE
680	ENSG00000173258	ZNF483	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	158399	zinc finger protein 483 [Source:HGNC Symbol;Acc:HGNC:23384]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000173258#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000311679#ENSG00000173258#ENST00000309235#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000438048#ENSG00000173258#ENST00000355824#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000350871#ENSG00000173258#ENST00000358151#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000363494#ENSG00000173258#ENST00000374374#C2H2 ZF Containing Proteins#SCAN	TRUE
681	ENSG00000127081	ZNF484	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	83744	zinc finger protein 484 [Source:HGNC Symbol;Acc:HGNC:23385]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	$#ENSG00000127081#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000364645#ENSG00000127081#ENST00000375495#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2, zinc_ribbon_15$#ENSP00000364646#ENSG00000127081#ENST00000332591#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000378881#ENSG00000127081#ENST00000395505#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2, zinc_ribbon_15$#ENSP00000378882#ENSG00000127081#ENST00000395506#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
682	ENSG00000198298	ZNF485	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	220992	zinc finger protein 485 [Source:HGNC Symbol;Acc:HGNC:23440]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000354694#ENSG00000198298#ENST00000361807#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363558#ENSG00000198298#ENST00000374435#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393570#ENSG00000198298#ENST00000430885#C2H2 ZF Containing Proteins#KRAB	TRUE
683	ENSG00000256229	ZNF486	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	90649	zinc finger protein 486 [Source:HGNC Symbol;Acc:HGNC:20807]	None	DBD and Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000335042#ENSG00000256229#ENST00000335117#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000469306#ENSG00000256229#ENST00000597083#C2H2 ZF Containing Proteins#KRAB	TRUE
684	ENSG00000243660	ZNF487	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Single C2H2 domain; Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;	None	zinc finger protein 487 [Source:HGNC Symbol;Acc:HGNC:23488]	None	not tested	not tested	None	None	No	No	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000314093#ENSG00000243660#ENST00000315429#Other#KRAB$#ENSP00000392335#ENSG00000243660#ENST00000437590#Other#$#ENSP00000395135#ENSG00000243660#ENST00000451167#Other#$#ENSP00000395343#ENSG00000243660#ENST00000456416#Other#	TRUE
685	ENSG00000265763	ZNF488	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has two znfC2H2 domains	IPR007087;IPR015880	118738	zinc finger protein 488 [Source:HGNC Symbol;Acc:HGNC:23535]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000462269#ENSG00000265763#ENST00000585316#C2H2 ZF Containing Proteins#$#ENSP00000468133#ENSG00000265763#ENST00000591025#C2H2 ZF Containing Proteins#	FALSE
686	ENSG00000188033	ZNF490	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	57474	zinc finger protein 490 [Source:HGNC Symbol;Acc:HGNC:23705]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000188033#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000311521#ENSG00000188033#ENST00000311437#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404112#ENSG00000188033#ENST00000440366#C2H2 ZF Containing Proteins#KRAB	TRUE
687	ENSG00000177599	ZNF491	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	126069	zinc finger protein 491 [Source:HGNC Symbol;Acc:HGNC:23706]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000313443#ENSG00000177599#ENST00000323169#C2H2 ZF Containing Proteins#$#ENSP00000392176#ENSG00000177599#ENST00000450087#C2H2 ZF Containing Proteins#zf-H2C2_2	FALSE
688	ENSG00000229676	ZNF492	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	57615	zinc finger protein 492 [Source:HGNC Symbol;Acc:HGNC:23707]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000413660#ENSG00000229676#ENST00000456783#C2H2 ZF Containing Proteins#	TRUE
689	ENSG00000196268	ZNF493	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	284443	zinc finger protein 493 [Source:HGNC Symbol;Acc:HGNC:23708]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000196268#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000340651#ENSG00000196268#ENST00000339914#C2H2 ZF Containing Proteins#KRAB$#ENSP00000347691#ENSG00000196268#ENST00000355504#C2H2 ZF Containing Proteins#$#ENSP00000376110#ENSG00000196268#ENST00000392288#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469368#ENSG00000196268#ENST00000596302#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469680#ENSG00000196268#ENST00000594390#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472110#ENSG00000196268#ENST00000599461#C2H2 ZF Containing Proteins#	FALSE
690	ENSG00000162714	ZNF496	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	84838	zinc finger protein 496 [Source:HGNC Symbol;Acc:HGNC:23713]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:15169884	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000162714#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000294753#ENSG00000162714#ENST00000294753#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000473324#ENSG00000162714#ENST00000461277#C2H2 ZF Containing Proteins#KRAB	TRUE
691	ENSG00000174586	ZNF497	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	162968	zinc finger protein 497 [Source:HGNC Symbol;Acc:HGNC:23714]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000402815#ENSG00000174586#ENST00000425453#C2H2 ZF Containing Proteins#ADK_lid$#ENSP00000311183#ENSG00000174586#ENST00000311044#C2H2 ZF Containing Proteins#ADK_lid$#ENSP00000471650#ENSG00000174586#ENST00000595763#C2H2 ZF Containing Proteins#	FALSE
692	ENSG00000103199	ZNF500	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	26048	zinc finger protein 500 [Source:HGNC Symbol;Acc:HGNC:23716]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000103199#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000219478#ENSG00000103199#ENST00000219478#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000445714#ENSG00000103199#ENST00000545009#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000464747#ENSG00000103199#ENST00000592425#C2H2 ZF Containing Proteins#$#ENSP00000465073#ENSG00000103199#ENST00000588942#C2H2 ZF Containing Proteins#	TRUE
693	ENSG00000186446	ZNF501	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	115560	zinc finger protein 501 [Source:HGNC Symbol;Acc:HGNC:23717]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000186446#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000379363#ENSG00000186446#ENST00000396048#C2H2 ZF Containing Proteins#$#ENSP00000482632#ENSG00000186446#ENST00000620116#C2H2 ZF Containing Proteins#	FALSE
694	ENSG00000196653	ZNF502	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	91392	zinc finger protein 502 [Source:HGNC Symbol;Acc:HGNC:23718]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000296091#ENSG00000196653#ENST00000296091#C2H2 ZF Containing Proteins#$#ENSP00000406469#ENSG00000196653#ENST00000436624#C2H2 ZF Containing Proteins#$#ENSP00000401717#ENSG00000196653#ENST00000411443#C2H2 ZF Containing Proteins#$#ENSP00000397390#ENSG00000196653#ENST00000449836#C2H2 ZF Containing Proteins#	FALSE
695	ENSG00000165655	ZNF503	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;IPR022129	84858	zinc finger protein 503 [Source:HGNC Symbol;Acc:HGNC:23589]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000361602#ENSG00000165655#ENST00000372524#C2H2 ZF Containing Proteins#nlz1	FALSE
696	ENSG00000081665	ZNF506	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	Has a nice cassette of znfC2H2 domains and a KRAB domain	IPR001909;IPR007087;IPR015880;	440515	zinc finger protein 506 [Source:HGNC Symbol;Acc:HGNC:23780]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000081665#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:25274305 | NAS - PMID:2023909	$#ENSP00000445149#ENSG00000081665#ENST00000545006#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393835#ENSG00000081665#ENST00000443905#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000440625#ENSG00000081665#ENST00000540806#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000468217#ENSG00000081665#ENST00000587461#C2H2 ZF Containing Proteins#KRAB	TRUE
697	ENSG00000168813	ZNF507	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	22847	zinc finger protein 507 [Source:HGNC Symbol;Acc:HGNC:23783]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000312277#ENSG00000168813#ENST00000311921#C2H2 ZF Containing Proteins#$#ENSP00000348162#ENSG00000168813#ENST00000355898#C2H2 ZF Containing Proteins#$#ENSP00000441549#ENSG00000168813#ENST00000544431#C2H2 ZF Containing Proteins#	FALSE
698	ENSG00000081386	ZNF510	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has decent cassettes of znfC2H2 domains	IPR001909;IPR007087;IPR015880;	22869	zinc finger protein 510 [Source:HGNC Symbol;Acc:HGNC:29161]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000223428#ENSG00000081386#ENST00000223428#C2H2 ZF Containing Proteins#KRAB$#ENSP00000364379#ENSG00000081386#ENST00000375231#C2H2 ZF Containing Proteins#KRAB$#ENSP00000363772#ENSG00000081386#ENST00000374641#C2H2 ZF Containing Proteins#KRAB	TRUE
699	ENSG00000198546	ZNF511	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	118472	zinc finger protein 511 [Source:HGNC Symbol;Acc:HGNC:28445]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000355251#ENSG00000198546#ENST00000361518#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_aberr$#ENSP00000351929#ENSG00000198546#ENST00000359035#C2H2 ZF Containing Proteins#zf-C2H2_aberr	FALSE
700	ENSG00000196700	ZNF512B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Protein has znfC2H2 domains but they are fragmented rather than making decent cassettes	IPR007087;IPR015880	57473	zinc finger protein 512B [Source:HGNC Symbol;Acc:HGNC:29212]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000358904#ENSG00000196700#ENST00000369888#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-met	FALSE
701	ENSG00000163795	ZNF513	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	130557	zinc finger protein 513 [Source:HGNC Symbol;Acc:HGNC:26498]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000318373#ENSG00000163795#ENST00000323703#C2H2 ZF Containing Proteins#$#ENSP00000384874#ENSG00000163795#ENST00000407879#C2H2 ZF Containing Proteins#$#ENSP00000394226#ENSG00000163795#ENST00000436006#C2H2 ZF Containing Proteins#zf-H2C2_5	FALSE
702	ENSG00000144026	ZNF514	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	84874	zinc finger protein 514 [Source:HGNC Symbol;Acc:HGNC:25894]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000144026#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000295208#ENSG00000144026#ENST00000295208#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405509#ENSG00000144026#ENST00000411425#C2H2 ZF Containing Proteins#KRAB$#ENSP00000399647#ENSG00000144026#ENST00000447814#C2H2 ZF Containing Proteins#KRAB	TRUE
703	ENSG00000101493	ZNF516	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	9658	zinc finger protein 516 [Source:HGNC Symbol;Acc:HGNC:28990]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000101493#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000394757#ENSG00000101493#ENST00000443185#C2H2 ZF Containing Proteins#$#ENSP00000478712#ENSG00000101493#ENST00000617840#C2H2 ZF Containing Proteins#$#ENSP00000446211#ENSG00000101493#ENST00000532857#C2H2 ZF Containing Proteins#$#ENSP00000445902#ENSG00000101493#ENST00000542818#C2H2 ZF Containing Proteins#	FALSE
704	ENSG00000197363	ZNF517	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	340385	zinc finger protein 517 [Source:HGNC Symbol;Acc:HGNC:27984]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000433299#ENSG00000197363#ENST00000525105#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432025#ENSG00000197363#ENST00000529429#C2H2 ZF Containing Proteins#$#ENSP00000436103#ENSG00000197363#ENST00000531720#C2H2 ZF Containing Proteins#KRAB$#ENSP00000353058#ENSG00000197363#ENST00000359971#C2H2 ZF Containing Proteins#KRAB	TRUE
705	ENSG00000177853	ZNF518A	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and that it interacts with polycomb repressor complex 2 PMID: 25680957	IPR007087;IPR015880	9849	zinc finger protein 518A [Source:HGNC Symbol;Acc:HGNC:29009]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000177853#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000479684#ENSG00000177853#ENST00000316045#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000480280#ENSG00000177853#ENST00000478086#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000485614#ENSG00000177853#ENST00000624776#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5$#ENSP00000481657#ENSG00000177853#ENST00000614149#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5	FALSE
706	ENSG00000178163	ZNF518B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	85460	zinc finger protein 518B [Source:HGNC Symbol;Acc:HGNC:29365]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000178163#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000317614#ENSG00000178163#ENST00000326756#C2H2 ZF Containing Proteins#$#ENSP00000425298#ENSG00000178163#ENST00000507515#C2H2 ZF Containing Proteins#	FALSE
707	ENSG00000175322	ZNF519	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	162655	zinc finger protein 519 [Source:HGNC Symbol;Acc:HGNC:30574]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000464872#ENSG00000175322#ENST00000590202#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465159#ENSG00000175322#ENST00000589498#C2H2 ZF Containing Proteins#KRAB	TRUE
708	ENSG00000198795	ZNF521	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	25925	zinc finger protein 521 [Source:HGNC Symbol;Acc:HGNC:24605]	None	Full	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	2a1, Lower confidence direct evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000354794#ENSG00000198795#ENST00000361524#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000463000#ENSG00000198795#ENST00000584787#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000440768#ENSG00000198795#ENST00000538137#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz, zf-D$#ENSP00000462746#ENSG00000198795#ENST00000577461#C2H2 ZF Containing Proteins#$#ENSP00000463748#ENSG00000198795#ENST00000577775#C2H2 ZF Containing Proteins#	FALSE
709	ENSG00000203326	ZNF525	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	None	zinc finger protein 525 [Source:HGNC Symbol;Acc:HGNC:29423]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000418468#ENSG00000203326#ENST00000475179#C2H2 ZF Containing Proteins#KRAB$#ENSP00000419136#ENSG00000203326#ENST00000467003#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000420476#ENSG00000203326#ENST00000491101#C2H2 ZF Containing Proteins#KRAB	FALSE
710	ENSG00000167625	ZNF526	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	116115	zinc finger protein 526 [Source:HGNC Symbol;Acc:HGNC:29415]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000301215#ENSG00000167625#ENST00000301215#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000473075#ENSG00000167625#ENST00000597945#C2H2 ZF Containing Proteins#	FALSE
711	ENSG00000189164	ZNF527	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	84503	zinc finger protein 527 [Source:HGNC Symbol;Acc:HGNC:29385]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000468344#ENSG00000189164#ENST00000483919#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466096#ENSG00000189164#ENST00000587349#C2H2 ZF Containing Proteins#KRAB$#ENSP00000390179#ENSG00000189164#ENST00000436120#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468517#ENSG00000189164#ENST00000588911#C2H2 ZF Containing Proteins#KRAB	TRUE
712	ENSG00000167555	ZNF528	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	84436	zinc finger protein 528 [Source:HGNC Symbol;Acc:HGNC:29384]	None	not tested	not tested	None	None	x	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000167555#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000353652#ENSG00000167555#ENST00000360465#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375665#ENSG00000167555#ENST00000391788#C2H2 ZF Containing Proteins#KRAB$#ENSP00000413711#ENSG00000167555#ENST00000436397#C2H2 ZF Containing Proteins#$#ENSP00000432992#ENSG00000167555#ENST00000493272#C2H2 ZF Containing Proteins#$#ENSP00000469481#ENSG00000167555#ENST00000594530#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470536#ENSG00000167555#ENST00000598192#C2H2 ZF Containing Proteins#KRAB	TRUE
713	ENSG00000186020	ZNF529	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	57711	zinc finger protein 529 [Source:HGNC Symbol;Acc:HGNC:29328]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000465578#ENSG00000186020#ENST00000591340#C2H2 ZF Containing Proteins#C1_4, KRAB, Zn-ribbon_8, zf-C2H2_6, zf-H2C2_2$#ENSP00000334695#ENSG00000186020#ENST00000334116#C2H2 ZF Containing Proteins#C1_4, Zn-ribbon_8, zf-C2H2_6, zf-H2C2_2$#ENSP00000465917#ENSG00000186020#ENST00000452073#C2H2 ZF Containing Proteins#$#ENSP00000468619#ENSG00000186020#ENST00000585983#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468594#ENSG00000186020#ENST00000590656#C2H2 ZF Containing Proteins#	TRUE
714	ENSG00000183647	ZNF530	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	348327	zinc finger protein 530 [Source:HGNC Symbol;Acc:HGNC:29297]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000332861#ENSG00000183647#ENST00000332854#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472024#ENSG00000183647#ENST00000597700#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471527#ENSG00000183647#ENST00000597864#C2H2 ZF Containing Proteins#KRAB	TRUE
715	ENSG00000074657	ZNF532	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has decent cassettes of znfC2H2 domains	IPR007087;IPR015880	55205	zinc finger protein 532 [Source:HGNC Symbol;Acc:HGNC:30940]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000074657#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000338217#ENSG00000074657#ENST00000336078#C2H2 ZF Containing Proteins#$#ENSP00000466007#ENSG00000074657#ENST00000589288#C2H2 ZF Containing Proteins#$#ENSP00000468532#ENSG00000074657#ENST00000591083#C2H2 ZF Containing Proteins#$#ENSP00000465709#ENSG00000074657#ENST00000591230#C2H2 ZF Containing Proteins#$#ENSP00000468238#ENSG00000074657#ENST00000591808#C2H2 ZF Containing Proteins#$#ENSP00000464894#ENSG00000074657#ENST00000586997#C2H2 ZF Containing Proteins#$#ENSP00000465873#ENSG00000074657#ENST00000592452#C2H2 ZF Containing Proteins#$#ENSP00000468009#ENSG00000074657#ENST00000588456#C2H2 ZF Containing Proteins#$#ENSP00000465802#ENSG00000074657#ENST00000590285#C2H2 ZF Containing Proteins#	FALSE
716	ENSG00000198633	ZNF534	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147658	zinc finger protein 534 [Source:HGNC Symbol;Acc:HGNC:26337]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000198633#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000327538#ENSG00000198633#ENST00000332323#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391358#ENSG00000198633#ENST00000433050#C2H2 ZF Containing Proteins#KRAB$#ENSP00000301085#ENSG00000198633#ENST00000301085#C2H2 ZF Containing Proteins#KRAB$#ENSP00000409421#ENSG00000198633#ENST00000432303#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480956#ENSG00000198633#ENST00000617900#C2H2 ZF Containing Proteins#KRAB	TRUE
717	ENSG00000198597	ZNF536	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	9745	zinc finger protein 536 [Source:HGNC Symbol;Acc:HGNC:29025]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000198597#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19398580	$#ENSP00000347730#ENSG00000198597#ENST00000355537#C2H2 ZF Containing Proteins#zf-C2H2_assoc$#ENSP00000465268#ENSG00000198597#ENST00000591488#C2H2 ZF Containing Proteins#$#ENSP00000465771#ENSG00000198597#ENST00000585628#C2H2 ZF Containing Proteins#zf-C2H2_assoc$#ENSP00000467909#ENSG00000198597#ENST00000592773#C2H2 ZF Containing Proteins#zf-H2C2_5	FALSE
718	ENSG00000171817	ZNF540	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	163255	zinc finger protein 540 [Source:HGNC Symbol;Acc:HGNC:25331]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000171817#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000324598#ENSG00000171817#ENST00000316433#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467118#ENSG00000171817#ENST00000589117#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466274#ENSG00000171817#ENST00000592533#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468113#ENSG00000171817#ENST00000586792#C2H2 ZF Containing Proteins#$#ENSP00000467667#ENSG00000171817#ENST00000590588#C2H2 ZF Containing Proteins#KRAB	TRUE
719	ENSG00000240225	ZNF542P	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	None	None	147947	Putative zinc finger protein 542	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000240225#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000240225##Other#	FALSE
720	ENSG00000178229	ZNF543	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	125919	zinc finger protein 543 [Source:HGNC Symbol;Acc:HGNC:25281]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000322545#ENSG00000178229#ENST00000321545#C2H2 ZF Containing Proteins#KRAB	TRUE
721	ENSG00000198131	ZNF544	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	27300	zinc finger protein 544 [Source:HGNC Symbol;Acc:HGNC:16759]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000198131#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000269829#ENSG00000198131#ENST00000269829#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000472614#ENSG00000198131#ENST00000594384#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469635#ENSG00000198131#ENST00000596652#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2$#ENSP00000472512#ENSG00000198131#ENST00000596825#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471480#ENSG00000198131#ENST00000599227#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485736#ENSG00000198131#ENST00000627781#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470843#ENSG00000198131#ENST00000595981#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471684#ENSG00000198131#ENST00000600220#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-C2H2_6, zf-H2C2_2	TRUE
722	ENSG00000187187	ZNF546	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	339327	zinc finger protein 546 [Source:HGNC Symbol;Acc:HGNC:28671]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000187187#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000339823#ENSG00000187187#ENST00000347077#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469540#ENSG00000187187#ENST00000600094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470423#ENSG00000187187#ENST00000596894#C2H2 ZF Containing Proteins#	TRUE
723	ENSG00000152433	ZNF547	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284306	zinc finger protein 547 [Source:HGNC Symbol;Acc:HGNC:26432]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000282282#ENSG00000152433#ENST00000282282#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470111#ENSG00000152433#ENST00000597567#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468929#ENSG00000152433#ENST00000599604#C2H2 ZF Containing Proteins#KRAB	TRUE
724	ENSG00000188785	ZNF548	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147694	zinc finger protein 548 [Source:HGNC Symbol;Acc:HGNC:26561]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000188785#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000379482#ENSG00000188785#ENST00000366197#C2H2 ZF Containing Proteins#KRAB$#ENSP00000337555#ENSG00000188785#ENST00000336128#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473179#ENSG00000188785#ENST00000597400#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470982#ENSG00000188785#ENST00000600927#C2H2 ZF Containing Proteins#KRAB	TRUE
725	ENSG00000121406	ZNF549	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	256051	zinc finger protein 549 [Source:HGNC Symbol;Acc:HGNC:26632]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000121406#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000365407#ENSG00000121406#ENST00000376233#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000469280#ENSG00000121406#ENST00000602149#C2H2 ZF Containing Proteins#KRAB$#ENSP00000240719#ENSG00000121406#ENST00000240719#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000471315#ENSG00000121406#ENST00000594943#C2H2 ZF Containing Proteins#	TRUE
726	ENSG00000251369	ZNF550	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	162972	zinc finger protein 550 [Source:HGNC Symbol;Acc:HGNC:28643]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000446224#ENSG00000251369#ENST00000325134#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445978#ENSG00000251369#ENST00000344222#C2H2 ZF Containing Proteins#$#ENSP00000469679#ENSG00000251369#ENST00000457177#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472973#ENSG00000251369#ENST00000601415#C2H2 ZF Containing Proteins#KRAB	TRUE
727	ENSG00000204519	ZNF551	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	90233	zinc finger protein 551 [Source:HGNC Symbol;Acc:HGNC:25108]	None	Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000204519#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000282296#ENSG00000204519#ENST00000282296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472674#ENSG00000204519#ENST00000601064#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472230#ENSG00000204519#ENST00000596085#C2H2 ZF Containing Proteins#KRAB	TRUE
728	ENSG00000178935	ZNF552	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	79818	zinc finger protein 552 [Source:HGNC Symbol;Acc:HGNC:26135]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000178935#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000375582#ENSG00000178935#ENST00000391701#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000472459#ENSG00000178935#ENST00000594473#C2H2 ZF Containing Proteins#KRAB	TRUE
729	ENSG00000172006	ZNF554	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	115196	zinc finger protein 554 [Source:HGNC Symbol;Acc:HGNC:26629]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000321132#ENSG00000172006#ENST00000317243#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467997#ENSG00000172006#ENST00000591265#C2H2 ZF Containing Proteins#KRAB	TRUE
730	ENSG00000186300	ZNF555	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	148254	zinc finger protein 555 [Source:HGNC Symbol;Acc:HGNC:28382]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000334853#ENSG00000186300#ENST00000334241#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467893#ENSG00000186300#ENST00000591539#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466982#ENSG00000186300#ENST00000585966#C2H2 ZF Containing Proteins#	TRUE
731	ENSG00000172000	ZNF556	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	80032	zinc finger protein 556 [Source:HGNC Symbol;Acc:HGNC:25669]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000467366#ENSG00000172000#ENST00000586426#C2H2 ZF Containing Proteins#KRAB$#ENSP00000302603#ENSG00000172000#ENST00000307635#C2H2 ZF Containing Proteins#KRAB	TRUE
732	ENSG00000130544	ZNF557	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	79230	zinc finger protein 557 [Source:HGNC Symbol;Acc:HGNC:28632]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000252840#ENSG00000130544#ENST00000252840#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404065#ENSG00000130544#ENST00000414706#C2H2 ZF Containing Proteins#KRAB	TRUE
733	ENSG00000167785	ZNF558	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	148156	zinc finger protein 558 [Source:HGNC Symbol;Acc:HGNC:26422]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000301475#ENSG00000167785#ENST00000301475#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471277#ENSG00000167785#ENST00000601372#C2H2 ZF Containing Proteins#KRAB	TRUE
734	ENSG00000188321	ZNF559	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	84527	zinc finger protein 559 [Source:HGNC Symbol;Acc:HGNC:28197]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000467048#ENSG00000188321#ENST00000585352#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465787#ENSG00000188321#ENST00000586255#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466496#ENSG00000188321#ENST00000592896#C2H2 ZF Containing Proteins#KRAB$#ENSP00000325393#ENSG00000188321#ENST00000317221#C2H2 ZF Containing Proteins#KRAB$#ENSP00000377461#ENSG00000188321#ENST00000393883#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468153#ENSG00000188321#ENST00000587557#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468299#ENSG00000188321#ENST00000592298#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467841#ENSG00000188321#ENST00000592504#C2H2 ZF Containing Proteins#KRAB$#ENSP00000474760#ENSG00000188321#ENST00000603380#C2H2 ZF Containing Proteins#KRAB$#ENSP00000474719#ENSG00000188321#ENST00000605750#C2H2 ZF Containing Proteins#$#ENSP00000466745#ENSG00000188321#ENST00000591652#C2H2 ZF Containing Proteins#KRAB	TRUE
735	ENSG00000198028	ZNF560	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	147741	zinc finger protein 560 [Source:HGNC Symbol;Acc:HGNC:26484]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000301480#ENSG00000198028#ENST00000301480#C2H2 ZF Containing Proteins#KRAB	TRUE
736	ENSG00000171469	ZNF561	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	93134	zinc finger protein 561 [Source:HGNC Symbol;Acc:HGNC:28684]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000171469#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000303915#ENSG00000171469#ENST00000302851#C2H2 ZF Containing Proteins#KRAB$#ENSP00000370284#ENSG00000171469#ENST00000326044#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393074#ENSG00000171469#ENST00000424629#C2H2 ZF Containing Proteins#$#ENSP00000392013#ENSG00000171469#ENST00000444611#C2H2 ZF Containing Proteins#KRAB	TRUE
737	ENSG00000171466	ZNF562	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	54811	zinc finger protein 562 [Source:HGNC Symbol;Acc:HGNC:25950]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000293648#ENSG00000171466#ENST00000293648#C2H2 ZF Containing Proteins#$#ENSP00000468039#ENSG00000171466#ENST00000587392#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466911#ENSG00000171466#ENST00000588653#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464716#ENSG00000171466#ENST00000590155#C2H2 ZF Containing Proteins#KRAB$#ENSP00000410734#ENSG00000171466#ENST00000453372#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466039#ENSG00000171466#ENST00000589542#C2H2 ZF Containing Proteins#KRAB	TRUE
738	ENSG00000188868	ZNF563	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147837	zinc finger protein 563 [Source:HGNC Symbol;Acc:HGNC:30498]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000293725#ENSG00000188868#ENST00000293725#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471960#ENSG00000188868#ENST00000594577#C2H2 ZF Containing Proteins#$#ENSP00000469879#ENSG00000188868#ENST00000595977#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_2$#ENSP00000472052#ENSG00000188868#ENST00000601858#C2H2 ZF Containing Proteins#	TRUE
739	ENSG00000249709	ZNF564	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	163050	zinc finger protein 564 [Source:HGNC Symbol;Acc:HGNC:31106]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000249709#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000340004#ENSG00000249709#ENST00000339282#C2H2 ZF Containing Proteins#KRAB$#ENSP00000408822#ENSG00000249709#ENST00000416136#C2H2 ZF Containing Proteins#$#ENSP00000470670#ENSG00000249709#ENST00000596193#C2H2 ZF Containing Proteins#	TRUE
740	ENSG00000196357	ZNF565	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147929	zinc finger protein 565 [Source:HGNC Symbol;Acc:HGNC:26726]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000196357#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000465906#ENSG00000196357#ENST00000591473#C2H2 ZF Containing Proteins#$#ENSP00000306869#ENSG00000196357#ENST00000304116#C2H2 ZF Containing Proteins#KRAB$#ENSP00000347234#ENSG00000196357#ENST00000355114#C2H2 ZF Containing Proteins#KRAB$#ENSP00000376013#ENSG00000196357#ENST00000392173#C2H2 ZF Containing Proteins#KRAB	TRUE
741	ENSG00000186017	ZNF566	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	84924	zinc finger protein 566 [Source:HGNC Symbol;Acc:HGNC:25919]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000465343#ENSG00000186017#ENST00000493391#C2H2 ZF Containing Proteins#$#ENSP00000401259#ENSG00000186017#ENST00000424129#C2H2 ZF Containing Proteins#KRAB$#ENSP00000400651#ENSG00000186017#ENST00000427002#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415520#ENSG00000186017#ENST00000434377#C2H2 ZF Containing Proteins#KRAB$#ENSP00000411526#ENSG00000186017#ENST00000452939#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467764#ENSG00000186017#ENST00000587567#C2H2 ZF Containing Proteins#	TRUE
742	ENSG00000189042	ZNF567	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	163081	zinc finger protein 567 [Source:HGNC Symbol;Acc:HGNC:28696]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000189042#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000353957#ENSG00000189042#ENST00000360729#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467379#ENSG00000189042#ENST00000585696#C2H2 ZF Containing Proteins#KRAB$#ENSP00000441838#ENSG00000189042#ENST00000536254#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467712#ENSG00000189042#ENST00000588311#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466458#ENSG00000189042#ENST00000589264#C2H2 ZF Containing Proteins#KRAB	TRUE
743	ENSG00000198453	ZNF568	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	374900	zinc finger protein 568 [Source:HGNC Symbol;Acc:HGNC:25392]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000198453#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000334685#ENSG00000198453#ENST00000333987#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394514#ENSG00000198453#ENST00000415168#C2H2 ZF Containing Proteins#KRAB$#ENSP00000407012#ENSG00000198453#ENST00000427117#C2H2 ZF Containing Proteins#KRAB$#ENSP00000389794#ENSG00000198453#ENST00000444991#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465833#ENSG00000198453#ENST00000586353#C2H2 ZF Containing Proteins#Toxin_16$#ENSP00000481819#ENSG00000198453#ENST00000619231#C2H2 ZF Containing Proteins#KRAB$#ENSP00000413396#ENSG00000198453#ENST00000455427#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000407153#ENSG00000198453#ENST00000455817#C2H2 ZF Containing Proteins#$#ENSP00000466901#ENSG00000198453#ENST00000587857#C2H2 ZF Containing Proteins#KRAB	TRUE
744	ENSG00000196437	ZNF569	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	148266	zinc finger protein 569 [Source:HGNC Symbol;Acc:HGNC:24737]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000325018#ENSG00000196437#ENST00000316950#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375992#ENSG00000196437#ENST00000392149#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375993#ENSG00000196437#ENST00000392150#C2H2 ZF Containing Proteins#$#ENSP00000466221#ENSG00000196437#ENST00000448051#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467046#ENSG00000196437#ENST00000589833#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465577#ENSG00000196437#ENST00000592490#C2H2 ZF Containing Proteins#	TRUE
745	ENSG00000171970	ZNF57	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of znfC2H2 domains and has been shown to be expressed in many tissues and to be able to repress transcription (PMID: 20356463).	IPR001909;IPR007087;IPR015880;	126295	zinc finger protein 57 [Source:HGNC Symbol;Acc:HGNC:13125]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000303696#ENSG00000171970#ENST00000306908#C2H2 ZF Containing Proteins#KRAB$#ENSP00000430223#ENSG00000171970#ENST00000523428#C2H2 ZF Containing Proteins#$#ENSP00000468191#ENSG00000171970#ENST00000590305#C2H2 ZF Containing Proteins#	TRUE
746	ENSG00000171827	ZNF570	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	148268	zinc finger protein 570 [Source:HGNC Symbol;Acc:HGNC:26416]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000171827#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000331540#ENSG00000171827#ENST00000330173#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467218#ENSG00000171827#ENST00000586475#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467246#ENSG00000171827#ENST00000589725#C2H2 ZF Containing Proteins#KRAB	TRUE
747	ENSG00000180479	ZNF571	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR008981;IPR015880	51276	zinc finger protein 571 [Source:HGNC Symbol;Acc:HGNC:25000]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000180479#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000333660#ENSG00000180479#ENST00000328550#C2H2 ZF Containing Proteins#KRAB$#ENSP00000392638#ENSG00000180479#ENST00000451802#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467572#ENSG00000180479#ENST00000593133#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351594#ENSG00000180479#ENST00000358744#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466225#ENSG00000180479#ENST00000590390#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468192#ENSG00000180479#ENST00000590751#C2H2 ZF Containing Proteins#KRAB	TRUE
748	ENSG00000180938	ZNF572	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	137209	zinc finger protein 572 [Source:HGNC Symbol;Acc:HGNC:26758]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000319305#ENSG00000180938#ENST00000319286#C2H2 ZF Containing Proteins#	FALSE
749	ENSG00000189144	ZNF573	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	126231	zinc finger protein 573 [Source:HGNC Symbol;Acc:HGNC:26420]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000189144#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000465020#ENSG00000189144#ENST00000590414#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375983#ENSG00000189144#ENST00000392138#C2H2 ZF Containing Proteins#$#ENSP00000367706#ENSG00000189144#ENST00000378445#C2H2 ZF Containing Proteins#KRAB$#ENSP00000440464#ENSG00000189144#ENST00000536220#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468391#ENSG00000189144#ENST00000588218#C2H2 ZF Containing Proteins#KRAB	TRUE
750	ENSG00000105732	ZNF574	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	64763	zinc finger protein 574 [Source:HGNC Symbol;Acc:HGNC:26166]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	None	$#ENSP00000351939#ENSG00000105732#ENST00000359044#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6$#ENSP00000469029#ENSG00000105732#ENST00000600245#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6$#ENSP00000222339#ENSG00000105732#ENST00000222339#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6$#ENSP00000471611#ENSG00000105732#ENST00000597391#C2H2 ZF Containing Proteins#	FALSE
751	ENSG00000176472	ZNF575	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	284346	zinc finger protein 575 [Source:HGNC Symbol;Acc:HGNC:27606]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000315870#ENSG00000176472#ENST00000314228#C2H2 ZF Containing Proteins#$#ENSP00000413956#ENSG00000176472#ENST00000458714#C2H2 ZF Containing Proteins#$#ENSP00000472578#ENSG00000176472#ENST00000601282#C2H2 ZF Containing Proteins#$#ENSP00000471083#ENSG00000176472#ENST00000598080#C2H2 ZF Containing Proteins#	FALSE
752	ENSG00000124444	ZNF576	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	79177	zinc finger protein 576 [Source:HGNC Symbol;Acc:HGNC:28357]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Tim Hughes	Yes	None	$#ENSP00000337852#ENSG00000124444#ENST00000336564#C2H2 ZF Containing Proteins#$#ENSP00000375827#ENSG00000124444#ENST00000391965#C2H2 ZF Containing Proteins#$#ENSP00000436182#ENSG00000124444#ENST00000525771#C2H2 ZF Containing Proteins#$#ENSP00000435463#ENSG00000124444#ENST00000529930#C2H2 ZF Containing Proteins#$#ENSP00000435899#ENSG00000124444#ENST00000533118#C2H2 ZF Containing Proteins#$#ENSP00000435934#ENSG00000124444#ENST00000528387#C2H2 ZF Containing Proteins#	FALSE
753	ENSG00000161551	ZNF577	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	84765	zinc finger protein 577 [Source:HGNC Symbol;Acc:HGNC:28673]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000161551#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000301399#ENSG00000161551#ENST00000301399#C2H2 ZF Containing Proteins#KRAB	TRUE
754	ENSG00000258405	ZNF578	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	147660	zinc finger protein 578 [Source:HGNC Symbol;Acc:HGNC:26449]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000459216#ENSG00000258405#ENST00000421239#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000470790#ENSG00000258405#ENST00000601120#C2H2 ZF Containing Proteins#KRAB	TRUE
755	ENSG00000218891	ZNF579	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	163033	zinc finger protein 579 [Source:HGNC Symbol;Acc:HGNC:26646]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000320188#ENSG00000218891#ENST00000325421#C2H2 ZF Containing Proteins#$#ENSP00000465146#ENSG00000218891#ENST00000592239#C2H2 ZF Containing Proteins#	FALSE
756	ENSG00000213015	ZNF580	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	51157	zinc finger protein 580 [Source:HGNC Symbol;Acc:HGNC:29473]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000320050#ENSG00000213015#ENST00000325333#C2H2 ZF Containing Proteins#$#ENSP00000446126#ENSG00000213015#ENST00000545125#C2H2 ZF Containing Proteins#$#ENSP00000465028#ENSG00000213015#ENST00000590190#C2H2 ZF Containing Proteins#$#ENSP00000467142#ENSG00000213015#ENST00000592461#C2H2 ZF Containing Proteins#$#ENSP00000468407#ENSG00000213015#ENST00000592881#C2H2 ZF Containing Proteins#$#ENSP00000443957#ENSG00000213015#ENST00000543039#C2H2 ZF Containing Proteins#	FALSE
757	ENSG00000171425	ZNF581	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;IPR015880	51545	zinc finger protein 581 [Source:HGNC Symbol;Acc:HGNC:25017]	None	DBD and Full	not tested	None	None	b	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000270451#ENSG00000171425#ENST00000270451#C2H2 ZF Containing Proteins#$#ENSP00000466047#ENSG00000171425#ENST00000587252#C2H2 ZF Containing Proteins#$#ENSP00000466338#ENSG00000171425#ENST00000585995#C2H2 ZF Containing Proteins#$#ENSP00000466564#ENSG00000171425#ENST00000588537#C2H2 ZF Containing Proteins#	FALSE
758	ENSG00000018869	ZNF582	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	147948	zinc finger protein 582 [Source:HGNC Symbol;Acc:HGNC:26421]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	None	$#ENSP00000301310#ENSG00000018869#ENST00000301310#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465619#ENSG00000018869#ENST00000586929#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000483414#ENSG00000018869#ENST00000619584#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465639#ENSG00000018869#ENST00000589895#C2H2 ZF Containing Proteins#KRAB	TRUE
759	ENSG00000198440	ZNF583	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	147949	zinc finger protein 583 [Source:HGNC Symbol;Acc:HGNC:26427]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000198440#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000388502#ENSG00000198440#ENST00000333201#C2H2 ZF Containing Proteins#KRAB$#ENSP00000291598#ENSG00000198440#ENST00000291598#C2H2 ZF Containing Proteins#KRAB$#ENSP00000444291#ENSG00000198440#ENST00000537943#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375657#ENSG00000198440#ENST00000391778#C2H2 ZF Containing Proteins#KRAB	TRUE
760	ENSG00000171574	ZNF584	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	201514	zinc finger protein 584 [Source:HGNC Symbol;Acc:HGNC:27318]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000171574#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000306756#ENSG00000171574#ENST00000306910#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470404#ENSG00000171574#ENST00000599238#C2H2 ZF Containing Proteins#$#ENSP00000320731#ENSG00000171574#ENST00000322834#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471105#ENSG00000171574#ENST00000593920#C2H2 ZF Containing Proteins#$#ENSP00000472853#ENSG00000171574#ENST00000596281#C2H2 ZF Containing Proteins#	TRUE
761	ENSG00000196967	ZNF585A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	199704	zinc finger protein 585A [Source:HGNC Symbol;Acc:HGNC:26305]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000196967#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000292841#ENSG00000196967#ENST00000292841#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375998#ENSG00000196967#ENST00000392157#C2H2 ZF Containing Proteins#$#ENSP00000466185#ENSG00000196967#ENST00000588354#C2H2 ZF Containing Proteins#$#ENSP00000349440#ENSG00000196967#ENST00000356958#C2H2 ZF Containing Proteins#	TRUE
762	ENSG00000245680	ZNF585B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;IPR013087	92285	zinc finger protein 585B [Source:HGNC Symbol;Acc:HGNC:30948]	None	DBD	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000245680#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000435268#ENSG00000245680#ENST00000527838#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433773#ENSG00000245680#ENST00000532828#C2H2 ZF Containing Proteins#KRAB$#ENSP00000436774#ENSG00000245680#ENST00000531805#C2H2 ZF Containing Proteins#$#ENSP00000467380#ENSG00000245680#ENST00000586320#C2H2 ZF Containing Proteins#KRAB	TRUE
763	ENSG00000083828	ZNF586	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	54807	zinc finger protein 586 [Source:HGNC Symbol;Acc:HGNC:25949]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000083828#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000379454#ENSG00000083828#ENST00000396150#C2H2 ZF Containing Proteins#$#ENSP00000379458#ENSG00000083828#ENST00000396154#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000375583#ENSG00000083828#ENST00000391702#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000472972#ENSG00000083828#ENST00000599802#C2H2 ZF Containing Proteins#	TRUE
764	ENSG00000198466	ZNF587	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	84914	zinc finger protein 587 [Source:HGNC Symbol;Acc:HGNC:30955]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000345479#ENSG00000198466#ENST00000339656#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000393865#ENSG00000198466#ENST00000423137#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000406999#ENSG00000198466#ENST00000419854#C2H2 ZF Containing Proteins#zf-C2H2_4	TRUE
765	ENSG00000269343	ZNF587B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880	100293516	zinc finger protein 587B [Source:HGNC Symbol;Acc:HGNC:37142]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000269343#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000392410#ENSG00000269343#ENST00000442832#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000472004#ENSG00000269343#ENST00000594328#C2H2 ZF Containing Proteins#$#ENSP00000469623#ENSG00000269343#ENST00000594901#C2H2 ZF Containing Proteins#KRAB	TRUE
766	ENSG00000164048	ZNF589	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001909;IPR007087;IPR015880;	51385	zinc finger protein 589 [Source:HGNC Symbol;Acc:HGNC:16747]	None	DBD and Full	not tested	None	None	b	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000346729#ENSG00000164048#ENST00000354698#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2, zinc_ribbon_9$#ENSP00000404398#ENSG00000164048#ENST00000412564#C2H2 ZF Containing Proteins#KRAB$#ENSP00000392719#ENSG00000164048#ENST00000427617#C2H2 ZF Containing Proteins#KRAB$#ENSP00000408719#ENSG00000164048#ENST00000440261#C2H2 ZF Containing Proteins#KRAB	TRUE
767	ENSG00000166716	ZNF592	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	9640	zinc finger protein 592 [Source:HGNC Symbol;Acc:HGNC:28986]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000299927#ENSG00000166716#ENST00000299927#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4$#ENSP00000452877#ENSG00000166716#ENST00000560079#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4	FALSE
768	ENSG00000142684	ZNF593	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein has a single atypical znfC2H2 domain that has been shown to inhibit binding of POU2F2 to DNA by interacting with POU2F2 (PMID: 18287285).	IPR003604;IPR007087;IPR022755;	51042	zinc finger protein 593 [Source:HGNC Symbol;Acc:HGNC:30943]	None	DBD and Full	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000363384#ENSG00000142684#ENST00000374266#C2H2 ZF Containing Proteins#DUF3073, zf-C2H2_2, zf-C2H2_jaz, zf-met$#ENSP00000270812#ENSG00000142684#ENST00000270812#C2H2 ZF Containing Proteins#DUF3073, zf-C2H2_2, zf-C2H2_jaz, zf-met	FALSE
769	ENSG00000180626	ZNF594	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	84622	zinc finger protein 594 [Source:HGNC Symbol;Acc:HGNC:29392]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000461696#ENSG00000180626#ENST00000576772#C2H2 ZF Containing Proteins#$#ENSP00000461032#ENSG00000180626#ENST00000575779#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000382513#ENSG00000180626#ENST00000399604#C2H2 ZF Containing Proteins#zf-C2H2_6	FALSE
770	ENSG00000272602	ZNF595	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	152687	zinc finger protein 595 [Source:HGNC Symbol;Acc:HGNC:27196]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000272602#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000434858#ENSG00000272602#ENST00000509152#C2H2 ZF Containing Proteins#KRAB$#ENSP00000477392#ENSG00000272602#ENST00000610261#C2H2 ZF Containing Proteins#KRAB$#ENSP00000476367#ENSG00000272602#ENST00000608255#C2H2 ZF Containing Proteins#$#ENSP00000476408#ENSG00000272602#ENST00000609518#C2H2 ZF Containing Proteins#KRAB	FALSE
771	ENSG00000172748	ZNF596	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	169270	zinc finger protein 596 [Source:HGNC Symbol;Acc:HGNC:27268]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000310033#ENSG00000172748#ENST00000308811#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000477126#ENSG00000172748#ENST00000522866#C2H2 ZF Containing Proteins#KRAB	TRUE
772	ENSG00000167981	ZNF597	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	146434	zinc finger protein 597 [Source:HGNC Symbol;Acc:HGNC:26573]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000301744#ENSG00000167981#ENST00000301744#C2H2 ZF Containing Proteins#KRAB	TRUE
773	ENSG00000167962	ZNF598	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001841;IPR007087;IPR015880;	90850	Zinc finger protein 598 [Source:HGNC Symbol;Acc:HGNC:28079]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000455308#ENSG00000167962#ENST00000562103#C2H2 ZF Containing Proteins#$#ENSP00000455882#ENSG00000167962#ENST00000563630#C2H2 ZF Containing Proteins#	FALSE
774	ENSG00000153896	ZNF599	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	148103	zinc finger protein 599 [Source:HGNC Symbol;Acc:HGNC:26408]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000468446#ENSG00000153896#ENST00000587354#C2H2 ZF Containing Proteins#KRAB$#ENSP00000333802#ENSG00000153896#ENST00000329285#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465262#ENSG00000153896#ENST00000588760#C2H2 ZF Containing Proteins#KRAB	TRUE
775	ENSG00000189190	ZNF600	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	162966	zinc finger protein 600 [Source:HGNC Symbol;Acc:HGNC:30951]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000189190#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000344791#ENSG00000189190#ENST00000338230#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2, zf-met	FALSE
776	ENSG00000196458	ZNF605	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	100289635	zinc finger protein 605 [Source:HGNC Symbol;Acc:HGNC:28068]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000196458#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000353314#ENSG00000196458#ENST00000360187#C2H2 ZF Containing Proteins#KRAB$#ENSP00000376135#ENSG00000196458#ENST00000392321#C2H2 ZF Containing Proteins#KRAB	TRUE
777	ENSG00000166704	ZNF606	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	80095	zinc finger protein 606 [Source:HGNC Symbol;Acc:HGNC:25879]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000166704#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000343617#ENSG00000166704#ENST00000341164#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000446972#ENSG00000166704#ENST00000551380#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000449865#ENSG00000166704#ENST00000547121#C2H2 ZF Containing Proteins#$#ENSP00000446487#ENSG00000166704#ENST00000547828#C2H2 ZF Containing Proteins#$#ENSP00000447075#ENSG00000166704#ENST00000552184#C2H2 ZF Containing Proteins#	TRUE
778	ENSG00000198182	ZNF607	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	84775	zinc finger protein 607 [Source:HGNC Symbol;Acc:HGNC:28192]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000198182#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000347338#ENSG00000198182#ENST00000355202#C2H2 ZF Containing Proteins#KRAB$#ENSP00000438015#ENSG00000198182#ENST00000395835#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466785#ENSG00000198182#ENST00000590670#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000468817#ENSG00000198182#ENST00000591664#C2H2 ZF Containing Proteins#KRAB	TRUE
779	ENSG00000168916	ZNF608	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;	57507	zinc finger protein 608 [Source:HGNC Symbol;Acc:HGNC:29238]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000307746#ENSG00000168916#ENST00000306315#C2H2 ZF Containing Proteins#$#ENSP00000427657#ENSG00000168916#ENST00000504926#C2H2 ZF Containing Proteins#$#ENSP00000423279#ENSG00000168916#ENST00000509799#C2H2 ZF Containing Proteins#$#ENSP00000421899#ENSG00000168916#ENST00000513986#C2H2 ZF Containing Proteins#	FALSE
780	ENSG00000180357	ZNF609	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;	23060	zinc finger protein 609 [Source:HGNC Symbol;Acc:HGNC:29003]	None	DBD	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000388846#ENSG00000180357#ENST00000416172#C2H2 ZF Containing Proteins#$#ENSP00000316527#ENSG00000180357#ENST00000326648#C2H2 ZF Containing Proteins#	FALSE
781	ENSG00000167554	ZNF610	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	162963	zinc finger protein 610 [Source:HGNC Symbol;Acc:HGNC:26687]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000324441#ENSG00000167554#ENST00000321287#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000383922#ENSG00000167554#ENST00000403906#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000471021#ENSG00000167554#ENST00000601151#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000477617#ENSG00000167554#ENST00000613461#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000327597#ENSG00000167554#ENST00000327920#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8$#ENSP00000485001#ENSG00000167554#ENST00000616431#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8	TRUE
782	ENSG00000213020	ZNF611	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	81856	zinc finger protein 611 [Source:HGNC Symbol;Acc:HGNC:28766]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000213020#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000469376#ENSG00000213020#ENST00000595798#C2H2 ZF Containing Proteins#zf-C2H2_6, zf-C2H2_jaz, zf-H2C2_2, zf-met$#ENSP00000322427#ENSG00000213020#ENST00000319783#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472648#ENSG00000213020#ENST00000602162#C2H2 ZF Containing Proteins#zf-C2H2_6, zf-C2H2_jaz, zf-H2C2_2, zf-met	TRUE
783	ENSG00000176024	ZNF613	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	79898	zinc finger protein 613 [Source:HGNC Symbol;Acc:HGNC:25827]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000176024#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000293471#ENSG00000176024#ENST00000293471#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375671#ENSG00000176024#ENST00000391794#C2H2 ZF Containing Proteins#$#ENSP00000490115#ENSG00000176024#ENST00000601794#C2H2 ZF Containing Proteins#$#ENSP00000472455#ENSG00000176024#ENST00000599683#C2H2 ZF Containing Proteins#KRAB	TRUE
784	ENSG00000142556	ZNF614	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880	80110	zinc finger protein 614 [Source:HGNC Symbol;Acc:HGNC:24722]	None	DBD and Full	not tested	None	None	No	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000270649#ENSG00000142556#ENST00000270649#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000348674#ENSG00000142556#ENST00000356322#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469809#ENSG00000142556#ENST00000597952#C2H2 ZF Containing Proteins#KRAB	TRUE
785	ENSG00000197619	ZNF615	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284370	zinc finger protein 615 [Source:HGNC Symbol;Acc:HGNC:24740]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000197619#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000471549#ENSG00000197619#ENST00000594083#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471041#ENSG00000197619#ENST00000598071#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483676#ENSG00000197619#ENST00000618487#C2H2 ZF Containing Proteins#KRAB$#ENSP00000365906#ENSG00000197619#ENST00000376716#C2H2 ZF Containing Proteins#KRAB$#ENSP00000375672#ENSG00000197619#ENST00000391795#C2H2 ZF Containing Proteins#KRAB	TRUE
786	ENSG00000204611	ZNF616	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	90317	zinc finger protein 616 [Source:HGNC Symbol;Acc:HGNC:28062]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000204611#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000328722#ENSG00000204611#ENST00000330123#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471000#ENSG00000204611#ENST00000600228#C2H2 ZF Containing Proteins#KRAB	TRUE
787	ENSG00000157657	ZNF618	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR012337;IPR015880;	114991	zinc finger protein 618 [Source:HGNC Symbol;Acc:HGNC:29416]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000288466#ENSG00000157657#ENST00000288466#C2H2 ZF Containing Proteins#Dimer_Tnp_hAT$#ENSP00000363241#ENSG00000157657#ENST00000374126#C2H2 ZF Containing Proteins#Dimer_Tnp_hAT$#ENSP00000483198#ENSG00000157657#ENST00000615615#C2H2 ZF Containing Proteins#Dimer_Tnp_hAT	FALSE
788	ENSG00000177873	ZNF619	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	285267	zinc finger protein 619 [Source:HGNC Symbol;Acc:HGNC:26910]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000322529#ENSG00000177873#ENST00000314686#C2H2 ZF Containing Proteins#$#ENSP00000397232#ENSG00000177873#ENST00000456778#C2H2 ZF Containing Proteins#	FALSE
789	ENSG00000177842	ZNF620	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	253639	zinc finger protein 620 [Source:HGNC Symbol;Acc:HGNC:28742]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000322265#ENSG00000177842#ENST00000314529#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391472#ENSG00000177842#ENST00000418905#C2H2 ZF Containing Proteins#$#ENSP00000406156#ENSG00000177842#ENST00000420891#C2H2 ZF Containing Proteins#KRAB	TRUE
790	ENSG00000172888	ZNF621	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	285268	zinc finger protein 621 [Source:HGNC Symbol;Acc:HGNC:24787]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000172888#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000340841#ENSG00000172888#ENST00000339296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000386051#ENSG00000172888#ENST00000403205#C2H2 ZF Containing Proteins#KRAB$#ENSP00000413236#ENSG00000172888#ENST00000431278#C2H2 ZF Containing Proteins#$#ENSP00000312144#ENSG00000172888#ENST00000310898#C2H2 ZF Containing Proteins#KRAB	TRUE
791	ENSG00000173545	ZNF622	C2H2 ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	ZNF622 lacks canonical Pfam matches to C2H2 domains and appears to have better homology to U1-type 1 ZFs involved in RNA recognition. Previous evidence for TF activity (PMID:12645566) was based on transcriptional regulation; and not DNA-binding.	IPR003604;IPR007087;IPR015880;IPR022755	90441	zinc finger protein 622 [Source:HGNC Symbol;Acc:HGNC:30958]	None	DBD and Full	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000310042#ENSG00000173545#ENST00000308683#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_jaz, zf-met	FALSE
792	ENSG00000183309	ZNF623	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	9831	Zinc finger protein 623 [Source:HGNC Symbol;Acc:HGNC:29084]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000183309#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000411139#ENSG00000183309#ENST00000458270#C2H2 ZF Containing Proteins#$#ENSP00000435232#ENSG00000183309#ENST00000526926#C2H2 ZF Containing Proteins#$#ENSP00000445979#ENSG00000183309#ENST00000501748#C2H2 ZF Containing Proteins#	FALSE
793	ENSG00000197566	ZNF624	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	57547	zinc finger protein 624 [Source:HGNC Symbol;Acc:HGNC:29254]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000197566#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000310472#ENSG00000197566#ENST00000311331#C2H2 ZF Containing Proteins#KRAB$#ENSP00000406525#ENSG00000197566#ENST00000423860#C2H2 ZF Containing Proteins#KRAB$#ENSP00000463295#ENSG00000197566#ENST00000583766#C2H2 ZF Containing Proteins#KRAB	TRUE
794	ENSG00000257591	ZNF625	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	None	90589	Zinc finger protein 625 [Source:HGNC Symbol;Acc:HGNC:30571]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000398518#ENSG00000257591#ENST00000455799#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394380#ENSG00000257591#ENST00000439556#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405156#ENSG00000257591#ENST00000414892#C2H2 ZF Containing Proteins#KRAB	FALSE
795	ENSG00000188171	ZNF626	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	199777	zinc finger protein 626 [Source:HGNC Symbol;Acc:HGNC:30461]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000291750#ENSG00000188171#ENST00000291750#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469566#ENSG00000188171#ENST00000595405#C2H2 ZF Containing Proteins#$#ENSP00000469958#ENSG00000188171#ENST00000601440#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484232#ENSG00000188171#ENST00000612591#C2H2 ZF Containing Proteins#KRAB	TRUE
796	ENSG00000198551	ZNF627	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	199692	zinc finger protein 627 [Source:HGNC Symbol;Acc:HGNC:30570]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000354414#ENSG00000198551#ENST00000361113#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465841#ENSG00000198551#ENST00000588174#C2H2 ZF Containing Proteins#KRAB$#ENSP00000464997#ENSG00000198551#ENST00000585493#C2H2 ZF Containing Proteins#$#ENSP00000466068#ENSG00000198551#ENST00000587939#C2H2 ZF Containing Proteins#	TRUE
797	ENSG00000197483	ZNF628	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains. The transfac model doesnt look like a common suspect	IPR007087;IPR015880	89887	zinc finger protein 628 [Source:HGNC Symbol;Acc:HGNC:28054]	None	Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000197483#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000469591#ENSG00000197483#ENST00000598519#C2H2 ZF Containing Proteins#$#ENSP00000465905#ENSG00000197483#ENST00000591164#C2H2 ZF Containing Proteins#$#ENSP00000375598#ENSG00000197483#ENST00000391718#C2H2 ZF Containing Proteins#	FALSE
798	ENSG00000102870	ZNF629	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	23361	zinc finger protein 629 [Source:HGNC Symbol;Acc:HGNC:29008]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Sam Lambert	Yes	$#ENSG00000102870#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000262525#ENSG00000102870#ENST00000262525#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2, zinc_ribbon_9	FALSE
799	ENSG00000221994	ZNF630	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	57232	zinc finger protein 630 [Source:HGNC Symbol;Acc:HGNC:28855]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	No	$#ENSG00000221994#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000354683#ENSG00000221994#ENST00000276054#C2H2 ZF Containing Proteins#$#ENSP00000386393#ENSG00000221994#ENST00000409324#C2H2 ZF Containing Proteins#KRAB$#ENSP00000485938#ENSG00000221994#ENST00000627643#C2H2 ZF Containing Proteins#KRAB	TRUE
800	ENSG00000121864	ZNF639	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Promotes transcription of HIV genes (PMID: 24204263).	IPR007087;IPR015880	51193	zinc finger protein 639 [Source:HGNC Symbol;Acc:HGNC:30950]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000121864#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20484494$#ENSG00000121864#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16182284	$#ENSP00000325634#ENSG00000121864#ENST00000326361#C2H2 ZF Containing Proteins#$#ENSP00000419650#ENSG00000121864#ENST00000466264#C2H2 ZF Containing Proteins#$#ENSP00000417740#ENSG00000121864#ENST00000496856#C2H2 ZF Containing Proteins#$#ENSP00000477626#ENSG00000121864#ENST00000621687#C2H2 ZF Containing Proteins#$#ENSP00000418766#ENSG00000121864#ENST00000484866#C2H2 ZF Containing Proteins#$#ENSP00000418628#ENSG00000121864#ENST00000481587#C2H2 ZF Containing Proteins#	FALSE
801	ENSG00000167528	ZNF641	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	121274	zinc finger protein 641 [Source:HGNC Symbol;Acc:HGNC:31834]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000167528#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000437832#ENSG00000167528#ENST00000544117#C2H2 ZF Containing Proteins#KRAB$#ENSP00000449974#ENSG00000167528#ENST00000547026#C2H2 ZF Containing Proteins#KRAB$#ENSP00000394627#ENSG00000167528#ENST00000448928#C2H2 ZF Containing Proteins#$#ENSP00000447381#ENSG00000167528#ENST00000550181#C2H2 ZF Containing Proteins#	TRUE
802	ENSG00000122482	ZNF644	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Possible false positive. Arrangement of C2H2 domains seems inconsistent with DNA binding.	IPR007087;IPR015880	84146	zinc finger protein 644 [Source:HGNC Symbol;Acc:HGNC:29222]	None	DBD and Full	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	Yes	None	$#ENSP00000337008#ENSG00000122482#ENST00000337393#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000340828#ENSG00000122482#ENST00000347275#C2H2 ZF Containing Proteins#$#ENSP00000354659#ENSG00000122482#ENST00000361321#C2H2 ZF Containing Proteins#	FALSE
803	ENSG00000175809	ZNF645	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR001841;IPR007087;IPR017907;	158506	zinc finger protein 645 [Source:HGNC Symbol;Acc:HGNC:26371]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000323348#ENSG00000175809#ENST00000323684#C2H2 ZF Containing Proteins#Prok-RING_4, zf-C3HC4, zf-C3HC4_3, zf-RING_5	FALSE
804	ENSG00000167395	ZNF646	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	9726	zinc finger protein 646 [Source:HGNC Symbol;Acc:HGNC:29004]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000300850#ENSG00000167395#ENST00000300850#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_jaz$#ENSP00000456651#ENSG00000167395#ENST00000564189#C2H2 ZF Containing Proteins#$#ENSP00000391271#ENSG00000167395#ENST00000428260#C2H2 ZF Containing Proteins#$#ENSP00000378429#ENSG00000167395#ENST00000394979#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_jaz	FALSE
805	ENSG00000179930	ZNF648	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	127665	zinc finger protein 648 [Source:HGNC Symbol;Acc:HGNC:18190]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000344129#ENSG00000179930#ENST00000339948#C2H2 ZF Containing Proteins#	FALSE
806	ENSG00000198093	ZNF649	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	65251	zinc finger protein 649 [Source:HGNC Symbol;Acc:HGNC:25741]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000198093#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000347043#ENSG00000198093#ENST00000354957#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468983#ENSG00000198093#ENST00000600738#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471756#ENSG00000198093#ENST00000599530#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469690#ENSG00000198093#ENST00000596690#C2H2 ZF Containing Proteins#KRAB	TRUE
807	ENSG00000198740	ZNF652	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	22834	zinc finger protein 652 [Source:HGNC Symbol;Acc:HGNC:29147]	None	Full	not tested	None	Cell paper model is for mouse ortholog Zfp652	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000354686#ENSG00000198740#ENST00000362063#C2H2 ZF Containing Proteins#$#ENSP00000416305#ENSG00000198740#ENST00000430262#C2H2 ZF Containing Proteins#	FALSE
808	ENSG00000175105	ZNF654	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	55279	zinc finger protein 654 [Source:HGNC Symbol;Acc:HGNC:25612]	None	DBD	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	Yes	None	$#ENSP00000312141#ENSG00000175105#ENST00000309495#C2H2 ZF Containing Proteins#$#ENSP00000490842#ENSG00000175105#ENST00000636215#C2H2 ZF Containing Proteins#	FALSE
809	ENSG00000197343	ZNF655	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR001909;IPR007087;IPR015880;	79027	zinc finger protein 655 [Source:HGNC Symbol;Acc:HGNC:30899]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000197343#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000252713#ENSG00000197343#ENST00000252713#C2H2 ZF Containing Proteins#$#ENSP00000322363#ENSG00000197343#ENST00000320583#C2H2 ZF Containing Proteins#KRAB$#ENSP00000377718#ENSG00000197343#ENST00000394163#C2H2 ZF Containing Proteins#$#ENSP00000350530#ENSG00000197343#ENST00000357864#C2H2 ZF Containing Proteins#$#ENSP00000389260#ENSG00000197343#ENST00000422164#C2H2 ZF Containing Proteins#$#ENSP00000393876#ENSG00000197343#ENST00000424881#C2H2 ZF Containing Proteins#$#ENSP00000396396#ENSG00000197343#ENST00000440391#C2H2 ZF Containing Proteins#$#ENSP00000398872#ENSG00000197343#ENST00000452314#C2H2 ZF Containing Proteins#$#ENSP00000419135#ENSG00000197343#ENST00000493277#C2H2 ZF Containing Proteins#$#ENSP00000392980#ENSG00000197343#ENST00000425063#C2H2 ZF Containing Proteins#	FALSE
810	ENSG00000274349	ZNF658	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001909;IPR007087;IPR015880;	26149	zinc finger protein 658 [Source:HGNC Symbol;Acc:HGNC:25226]	None	Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000274349#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000482540#ENSG00000274349#ENST00000612867#C2H2 ZF Containing Proteins#KRAB$#ENSP00000482447#ENSG00000274349#ENST00000621410#C2H2 ZF Containing Proteins#KRAB	TRUE
811	ENSG00000160229	ZNF66	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880	None	zinc finger protein 66 [Source:HGNC Symbol;Acc:HGNC:13135]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	Yes	None	None	FALSE
812	ENSG00000144792	ZNF660	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	285349	zinc finger protein 660 [Source:HGNC Symbol;Acc:HGNC:26720]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000144792#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000324605#ENSG00000144792#ENST00000322734#C2H2 ZF Containing Proteins#$#ENSP00000405284#ENSG00000144792#ENST00000416644#C2H2 ZF Containing Proteins#$#ENSP00000411996#ENSG00000144792#ENST00000441021#C2H2 ZF Containing Proteins#	FALSE
813	ENSG00000182983	ZNF662	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	389114	zinc finger protein 662 [Source:HGNC Symbol;Acc:HGNC:31930]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000408945#ENSG00000182983#ENST00000422021#C2H2 ZF Containing Proteins#$#ENSP00000405047#ENSG00000182983#ENST00000440367#C2H2 ZF Containing Proteins#$#ENSP00000329264#ENSG00000182983#ENST00000328199#C2H2 ZF Containing Proteins#KRAB	TRUE
814	ENSG00000179195	ZNF664	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	144348	zinc finger protein 664 [Source:HGNC Symbol;Acc:HGNC:25406]	None	DBD and Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000337320#ENSG00000179195#ENST00000337815#C2H2 ZF Containing Proteins#$#ENSP00000376205#ENSG00000179195#ENST00000392404#C2H2 ZF Containing Proteins#$#ENSP00000441405#ENSG00000179195#ENST00000539644#C2H2 ZF Containing Proteins#$#ENSP00000440645#ENSG00000179195#ENST00000538932#C2H2 ZF Containing Proteins#	FALSE
815	ENSG00000197497	ZNF665	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	79788	zinc finger protein 665 [Source:HGNC Symbol;Acc:HGNC:25885]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000379702#ENSG00000197497#ENST00000396424#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469154#ENSG00000197497#ENST00000600412#C2H2 ZF Containing Proteins#	FALSE
816	ENSG00000198046	ZNF667	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	63934	zinc finger protein 667 [Source:HGNC Symbol;Acc:HGNC:28854]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000292069#ENSG00000198046#ENST00000292069#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439402#ENSG00000198046#ENST00000504904#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468550#ENSG00000198046#ENST00000591790#C2H2 ZF Containing Proteins#KRAB	TRUE
817	ENSG00000167394	ZNF668	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	79759	zinc finger protein 668 [Source:HGNC Symbol;Acc:HGNC:25821]	None	DBD	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15539151	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000167394#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000300849#ENSG00000167394#ENST00000300849#C2H2 ZF Containing Proteins#$#ENSP00000416853#ENSG00000167394#ENST00000442862#C2H2 ZF Containing Proteins#$#ENSP00000440149#ENSG00000167394#ENST00000538906#C2H2 ZF Containing Proteins#$#ENSP00000412340#ENSG00000167394#ENST00000414399#C2H2 ZF Containing Proteins#$#ENSP00000390671#ENSG00000167394#ENST00000417935#C2H2 ZF Containing Proteins#zf-H2C2_2	FALSE
818	ENSG00000188295	ZNF669	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	79862	zinc finger protein 669 [Source:HGNC Symbol;Acc:HGNC:25736]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000342818#ENSG00000188295#ENST00000343381#C2H2 ZF Containing Proteins#KRAB$#ENSP00000404370#ENSG00000188295#ENST00000448299#C2H2 ZF Containing Proteins#KRAB$#ENSP00000355456#ENSG00000188295#ENST00000366500#C2H2 ZF Containing Proteins#KRAB$#ENSP00000355457#ENSG00000188295#ENST00000366501#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429550#ENSG00000188295#ENST00000476158#C2H2 ZF Containing Proteins#KRAB	TRUE
819	ENSG00000277462	ZNF670	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of znfC2H2 domains and a KRAB domain	None	None	zinc finger protein 670	None	not tested	not tested	None	Has a nice cassette of znfC2H2 domains and a KRAB domain	No	Yes	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
820	ENSG00000083814	ZNF671	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	79891	zinc finger protein 671 [Source:HGNC Symbol;Acc:HGNC:26279]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000321848#ENSG00000083814#ENST00000317398#C2H2 ZF Containing Proteins#DZR, KRAB, zf-H2C2_2$#ENSP00000468976#ENSG00000083814#ENST00000596939#C2H2 ZF Containing Proteins#	TRUE
821	ENSG00000171161	ZNF672	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	79894	zinc finger protein 672 [Source:HGNC Symbol;Acc:HGNC:26179]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000421915#ENSG00000171161#ENST00000306562#C2H2 ZF Containing Proteins#$#ENSP00000427021#ENSG00000171161#ENST00000428515#C2H2 ZF Containing Proteins#$#ENSP00000422534#ENSG00000171161#ENST00000505503#C2H2 ZF Containing Proteins#$#ENSP00000426199#ENSG00000171161#ENST00000423362#C2H2 ZF Containing Proteins#	FALSE
822	ENSG00000251192	ZNF674	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	641339	zinc finger protein 674 [Source:HGNC Symbol;Acc:HGNC:17625]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000429148#ENSG00000251192#ENST00000523374#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428248#ENSG00000251192#ENST00000414387#C2H2 ZF Containing Proteins#KRAB$#ENSP00000429646#ENSG00000251192#ENST00000518708#C2H2 ZF Containing Proteins#KRAB	TRUE
823	ENSG00000197372	ZNF675	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	171392	zinc finger protein 675 [Source:HGNC Symbol;Acc:HGNC:30768]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000197372#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11751921	$#ENSP00000352836#ENSG00000197372#ENST00000359788#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469379#ENSG00000197372#ENST00000601935#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469271#ENSG00000197372#ENST00000599168#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473035#ENSG00000197372#ENST00000599535#C2H2 ZF Containing Proteins#	TRUE
824	ENSG00000196109	ZNF676	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	163223	zinc finger protein 676 [Source:HGNC Symbol;Acc:HGNC:20429]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000380310#ENSG00000196109#ENST00000397121#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
825	ENSG00000197928	ZNF677	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	342926	zinc finger protein 677 [Source:HGNC Symbol;Acc:HGNC:28730]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000197928#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000334394#ENSG00000197928#ENST00000333952#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472416#ENSG00000197928#ENST00000594517#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469391#ENSG00000197928#ENST00000598513#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471071#ENSG00000197928#ENST00000598806#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472132#ENSG00000197928#ENST00000594681#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472783#ENSG00000197928#ENST00000601413#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471266#ENSG00000197928#ENST00000601828#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469701#ENSG00000197928#ENST00000599012#C2H2 ZF Containing Proteins#KRAB	TRUE
826	ENSG00000181450	ZNF678	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	339500	zinc finger protein 678 [Source:HGNC Symbol;Acc:HGNC:28652]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000344828#ENSG00000181450#ENST00000343776#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4, zf-H2C2_2$#ENSP00000440403#ENSG00000181450#ENST00000397097#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_4, zf-H2C2_2$#ENSP00000477097#ENSG00000181450#ENST00000608949#C2H2 ZF Containing Proteins#$#ENSP00000394651#ENSG00000181450#ENST00000440339#C2H2 ZF Containing Proteins#KRAB	FALSE
827	ENSG00000197123	ZNF679	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001909;IPR007087;IPR015880;	168417	zinc finger protein 679 [Source:HGNC Symbol;Acc:HGNC:28650]	None	Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000255746#ENSG00000197123#ENST00000255746#C2H2 ZF Containing Proteins#BolA, C1_4, KRAB, zf-H2C2_2$#ENSP00000416809#ENSG00000197123#ENST00000421025#C2H2 ZF Containing Proteins#BolA, C1_4, KRAB, zf-H2C2_2	TRUE
828	ENSG00000173041	ZNF680	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	340252	zinc finger protein 680 [Source:HGNC Symbol;Acc:HGNC:26897]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000309330#ENSG00000173041#ENST00000309683#C2H2 ZF Containing Proteins#KRAB$#ENSP00000393506#ENSG00000173041#ENST00000447137#C2H2 ZF Containing Proteins#KRAB	TRUE
829	ENSG00000196172	ZNF681	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	148213	zinc finger protein 681 [Source:HGNC Symbol;Acc:HGNC:26457]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000196172#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000384000#ENSG00000196172#ENST00000402377#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433806#ENSG00000196172#ENST00000528059#C2H2 ZF Containing Proteins#$#ENSP00000435824#ENSG00000196172#ENST00000531570#C2H2 ZF Containing Proteins#	TRUE
830	ENSG00000197124	ZNF682	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	91120	zinc finger protein 682 [Source:HGNC Symbol;Acc:HGNC:28857]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000470718#ENSG00000197124#ENST00000597972#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351324#ENSG00000197124#ENST00000358523#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380351#ENSG00000197124#ENST00000397165#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471717#ENSG00000197124#ENST00000595736#C2H2 ZF Containing Proteins#$#ENSP00000471745#ENSG00000197124#ENST00000594127#C2H2 ZF Containing Proteins#	TRUE
831	ENSG00000176083	ZNF683	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	257101	zinc finger protein 683 [Source:HGNC Symbol;Acc:HGNC:28495]	None	DBD	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000344095#ENSG00000176083#ENST00000349618#C2H2 ZF Containing Proteins#$#ENSP00000384782#ENSG00000176083#ENST00000403843#C2H2 ZF Containing Proteins#$#ENSP00000391584#ENSG00000176083#ENST00000423508#C2H2 ZF Containing Proteins#$#ENSP00000411290#ENSG00000176083#ENST00000451801#C2H2 ZF Containing Proteins#$#ENSP00000411289#ENSG00000176083#ENST00000455900#C2H2 ZF Containing Proteins#$#ENSP00000401961#ENSG00000176083#ENST00000416125#C2H2 ZF Containing Proteins#$#ENSP00000406734#ENSG00000176083#ENST00000453132#C2H2 ZF Containing Proteins#	FALSE
832	ENSG00000117010	ZNF684	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	127396	zinc finger protein 684 [Source:HGNC Symbol;Acc:HGNC:28418]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000361784#ENSG00000117010#ENST00000372699#C2H2 ZF Containing Proteins#KRAB$#ENSP00000361781#ENSG00000117010#ENST00000372696#C2H2 ZF Containing Proteins#KRAB$#ENSP00000361782#ENSG00000117010#ENST00000372697#C2H2 ZF Containing Proteins#KRAB	TRUE
833	ENSG00000143373	ZNF687	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	57592	zinc finger protein 687 [Source:HGNC Symbol;Acc:HGNC:29277]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000319829#ENSG00000143373#ENST00000324048#C2H2 ZF Containing Proteins#$#ENSP00000336620#ENSG00000143373#ENST00000336715#C2H2 ZF Containing Proteins#$#ENSP00000395261#ENSG00000143373#ENST00000443959#C2H2 ZF Containing Proteins#$#ENSP00000398821#ENSG00000143373#ENST00000426871#C2H2 ZF Containing Proteins#	FALSE
834	ENSG00000229809	ZNF688	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880	146542	zinc finger protein 688 [Source:HGNC Symbol;Acc:HGNC:30489]	None	DBD and Full	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	No	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000223459#ENSG00000229809#ENST00000223459#C2H2 ZF Containing Proteins#KRAB$#ENSP00000455227#ENSG00000229809#ENST00000563276#C2H2 ZF Containing Proteins#$#ENSP00000457222#ENSG00000229809#ENST00000567855#C2H2 ZF Containing Proteins#KRAB$#ENSP00000456070#ENSG00000229809#ENST00000563707#C2H2 ZF Containing Proteins#KRAB$#ENSP00000456047#ENSG00000229809#ENST00000566632#C2H2 ZF Containing Proteins#	TRUE
835	ENSG00000156853	ZNF689	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain and that it downregulates expression of BCL2 proteins in some types of liver cancer PMID: 21624362	IPR001909;IPR007087;IPR015880;	115509	zinc finger protein 689 [Source:HGNC Symbol;Acc:HGNC:25173]	None	DBD and Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000287461#ENSG00000156853#ENST00000287461#C2H2 ZF Containing Proteins#KRAB	TRUE
836	ENSG00000198429	ZNF69	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7620	zinc finger protein 69 [Source:HGNC Symbol;Acc:HGNC:13138]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000345333#ENSG00000198429#ENST00000340180#C2H2 ZF Containing Proteins#KRAB$#ENSP00000402985#ENSG00000198429#ENST00000429654#C2H2 ZF Containing Proteins#KRAB$#ENSP00000388784#ENSG00000198429#ENST00000445911#C2H2 ZF Containing Proteins#KRAB	TRUE
837	ENSG00000164011	ZNF691	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	51058	Zinc finger protein 691 [Source:HGNC Symbol;Acc:HGNC:28028]	None	not tested	not tested	None	None	b	Yes	No	No	1a2, Orthologous HQ evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000164011#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000361586#ENSG00000164011#ENST00000372508#C2H2 ZF Containing Proteins#$#ENSP00000361580#ENSG00000164011#ENST00000372502#C2H2 ZF Containing Proteins#$#ENSP00000361581#ENSG00000164011#ENST00000372503#C2H2 ZF Containing Proteins#$#ENSP00000361584#ENSG00000164011#ENST00000372506#C2H2 ZF Containing Proteins#$#ENSP00000361585#ENSG00000164011#ENST00000372507#C2H2 ZF Containing Proteins#$#ENSP00000380228#ENSG00000164011#ENST00000397034#C2H2 ZF Containing Proteins#$#ENSP00000486871#ENSG00000164011#ENST00000630961#C2H2 ZF Containing Proteins#	FALSE
838	ENSG00000171163	ZNF692	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR007087;IPR015880	55657	zinc finger protein 692 [Source:HGNC Symbol;Acc:HGNC:26049]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000305483#ENSG00000171163#ENST00000306601#C2H2 ZF Containing Proteins#$#ENSP00000355427#ENSG00000171163#ENST00000366471#C2H2 ZF Containing Proteins#$#ENSP00000391200#ENSG00000171163#ENST00000451251#C2H2 ZF Containing Proteins#$#ENSP00000431582#ENSG00000171163#ENST00000476503#C2H2 ZF Containing Proteins#$#ENSP00000432300#ENSG00000171163#ENST00000496231#C2H2 ZF Containing Proteins#	FALSE
839	ENSG00000197472	ZNF695	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	57116	zinc finger protein 695 [Source:HGNC Symbol;Acc:HGNC:30954]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000341236#ENSG00000197472#ENST00000339986#C2H2 ZF Containing Proteins#KRAB, Zn-ribbon_8, zf-C2H2_6, zf-H2C2_2$#ENSP00000429736#ENSG00000197472#ENST00000487338#C2H2 ZF Containing Proteins#KRAB	TRUE
840	ENSG00000185730	ZNF696	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	79943	zinc finger protein 696 [Source:HGNC Symbol;Acc:HGNC:25872]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000185730#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000328515#ENSG00000185730#ENST00000330143#C2H2 ZF Containing Proteins#$#ENSP00000429859#ENSG00000185730#ENST00000521537#C2H2 ZF Containing Proteins#$#ENSP00000427857#ENSG00000185730#ENST00000518575#C2H2 ZF Containing Proteins#	FALSE
841	ENSG00000143067	ZNF697	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	90874	zinc finger protein 697 [Source:HGNC Symbol;Acc:HGNC:32034]	None	DBD and Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000396857#ENSG00000143067#ENST00000421812#C2H2 ZF Containing Proteins#	FALSE
842	ENSG00000196110	ZNF699	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	374879	zinc finger protein 699 [Source:HGNC Symbol;Acc:HGNC:24750]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000196110#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000311596#ENSG00000196110#ENST00000308650#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000467723#ENSG00000196110#ENST00000591998#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
843	ENSG00000147789	ZNF7	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7553	zinc finger protein 7 [Source:HGNC Symbol;Acc:HGNC:13139]	None	not tested	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000147789#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000393260#ENSG00000147789#ENST00000446747#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432724#ENSG00000147789#ENST00000528372#C2H2 ZF Containing Proteins#KRAB$#ENSP00000432641#ENSG00000147789#ENST00000532777#C2H2 ZF Containing Proteins#KRAB$#ENSP00000435252#ENSG00000147789#ENST00000525266#C2H2 ZF Containing Proteins#KRAB$#ENSP00000439424#ENSG00000147789#ENST00000544249#C2H2 ZF Containing Proteins#	TRUE
844	ENSG00000187792	ZNF70	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	7621	zinc finger protein 70 [Source:HGNC Symbol;Acc:HGNC:13140]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000339314#ENSG00000187792#ENST00000341976#C2H2 ZF Containing Proteins#	FALSE
845	ENSG00000196757	ZNF700	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	90592	zinc finger protein 700 [Source:HGNC Symbol;Acc:HGNC:25292]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000254321#ENSG00000196757#ENST00000254321#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467996#ENSG00000196757#ENST00000482090#C2H2 ZF Containing Proteins#KRAB$#ENSP00000479449#ENSG00000196757#ENST00000622593#C2H2 ZF Containing Proteins#KRAB	TRUE
846	ENSG00000167562	ZNF701	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	55762	zinc finger protein 701 [Source:HGNC Symbol;Acc:HGNC:25597]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	None	$#ENSP00000301093#ENSG00000167562#ENST00000301093#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000375662#ENSG00000167562#ENST00000391785#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000444339#ENSG00000167562#ENST00000540331#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000471080#ENSG00000167562#ENST00000593941#C2H2 ZF Containing Proteins#KRAB	TRUE
847	ENSG00000183779	ZNF703	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;IPR022129	80139	zinc finger protein 703 [Source:HGNC Symbol;Acc:HGNC:25883]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	No	None	$#ENSP00000332325#ENSG00000183779#ENST00000331569#C2H2 ZF Containing Proteins#nlz1	FALSE
848	ENSG00000164684	ZNF704	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Single C2H2 domain	None	IPR007087;	619279	zinc finger protein 704 [Source:HGNC Symbol;Acc:HGNC:32291]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000331462#ENSG00000164684#ENST00000327835#C2H2 ZF Containing Proteins#$#ENSP00000427715#ENSG00000164684#ENST00000519936#C2H2 ZF Containing Proteins#	FALSE
849	ENSG00000196946	ZNF705A	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	Contains decent cassette of znfC2H2 domains and a KRAB-domain.	IPR001909;IPR007087;IPR015880;	100131539	zinc finger protein 705A [Source:HGNC Symbol;Acc:HGNC:32281]	None	Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000352233#ENSG00000196946#ENST00000359286#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000384896#ENSG00000196946#ENST00000402465#C2H2 ZF Containing Proteins#KRAB$#ENSP00000475525#ENSG00000196946#ENST00000398526#C2H2 ZF Containing Proteins#	TRUE
850	ENSG00000215356	ZNF705B	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001909;IPR007087;IPR015880;	100132396	zinc finger protein 705B [Source:HGNC Symbol;Acc:HGNC:32284]	None	not tested	not tested	None	None	c	Yes	No	No	2a2, orthologous lower confidence evidence	Pratyush Das	Sam Lambert	No	None	$#ENSP00000382987#ENSG00000215356#ENST00000400120#C2H2 ZF Containing Proteins#KRAB	TRUE
851	ENSG00000215343	ZNF705D	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001909;IPR007087;IPR015880;	728957	zinc finger protein 705D [Source:HGNC Symbol;Acc:HGNC:33202]	None	Full	not tested	None	None	b	Yes	No	No	2a2, orthologous lower confidence evidence	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000445477#ENSG00000215343#ENST00000400078#C2H2 ZF Containing Proteins#KRAB$#ENSP00000382957#ENSG00000215343#ENST00000400085#C2H2 ZF Containing Proteins#KRAB	TRUE
852	ENSG00000214534	ZNF705E	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of znfC2H2 domains and a KRAB domain	None	None	zinc finger protein 705E	None	DBD	not tested	None	Has a nice cassette of znfC2H2 domains and a KRAB domain	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
853	ENSG00000215372	ZNF705G	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	100131980	zinc finger protein 705G [Source:HGNC Symbol;Acc:HGNC:37134]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000383020#ENSG00000215372#ENST00000400156#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
854	ENSG00000120963	ZNF706	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007513;	51123	zinc finger protein 706 [Source:HGNC Symbol;Acc:HGNC:24992]	None	DBD and Full	not tested	None	Has no ZNFs	b	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	None	$#ENSP00000311768#ENSG00000120963#ENST00000311212#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000430823#ENSG00000120963#ENST00000520347#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000428227#ENSG00000120963#ENST00000517844#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000427803#ENSG00000120963#ENST00000519103#Other#$#ENSP00000429645#ENSG00000120963#ENST00000519744#Other#4F5$#ENSP00000428985#ENSG00000120963#ENST00000519882#Other#4F5, zf-C2H2_jaz, zf-met$#ENSP00000430090#ENSG00000120963#ENST00000520454#Other#$#ENSP00000429260#ENSG00000120963#ENST00000523922#Other#4F5	FALSE
855	ENSG00000181135	ZNF707	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	101928160	zinc finger protein 707 [Source:HGNC Symbol;Acc:HGNC:27815]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000413215#ENSG00000181135#ENST00000418203#C2H2 ZF Containing Proteins#KRAB$#ENSP00000436250#ENSG00000181135#ENST00000532158#C2H2 ZF Containing Proteins#KRAB$#ENSP00000351482#ENSG00000181135#ENST00000358656#C2H2 ZF Containing Proteins#KRAB$#ENSP00000436212#ENSG00000181135#ENST00000532205#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437134#ENSG00000181135#ENST00000534303#C2H2 ZF Containing Proteins#KRAB	TRUE
856	ENSG00000182141	ZNF708	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7562	Zinc finger protein 708 [Source:HGNC Symbol;Acc:HGNC:12945]	None	not tested	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000349401#ENSG00000182141#ENST00000356929#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469961#ENSG00000182141#ENST00000601295#C2H2 ZF Containing Proteins#$#ENSP00000471855#ENSG00000182141#ENST00000602023#C2H2 ZF Containing Proteins#	FALSE
857	ENSG00000242852	ZNF709	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	163051	zinc finger protein 709 [Source:HGNC Symbol;Acc:HGNC:20629]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	Yes	None	$#ENSP00000380840#ENSG00000242852#ENST00000397732#C2H2 ZF Containing Proteins#KRAB$#ENSP00000398085#ENSG00000242852#ENST00000455490#C2H2 ZF Containing Proteins#KRAB	TRUE
858	ENSG00000197951	ZNF71	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	58491	zinc finger protein 71 [Source:HGNC Symbol;Acc:HGNC:13141]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000197951#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000328245#ENSG00000197951#ENST00000328070#C2H2 ZF Containing Proteins#$#ENSP00000471138#ENSG00000197951#ENST00000599599#C2H2 ZF Containing Proteins#	FALSE
859	ENSG00000140548	ZNF710	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known about this protein except that it has a nice array of znfC2H2 domains	IPR007087;IPR015880	374655	zinc finger protein 710 [Source:HGNC Symbol;Acc:HGNC:25352]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000268154#ENSG00000140548#ENST00000268154#C2H2 ZF Containing Proteins#$#ENSP00000453404#ENSG00000140548#ENST00000558883#C2H2 ZF Containing Proteins#$#ENSP00000453147#ENSG00000140548#ENST00000559360#C2H2 ZF Containing Proteins#$#ENSP00000452993#ENSG00000140548#ENST00000559419#C2H2 ZF Containing Proteins#	FALSE
860	ENSG00000147180	ZNF711	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR006794;IPR007087;IPR015880;	7552	zinc finger protein 711 [Source:HGNC Symbol;Acc:HGNC:13128]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000147180#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000276123#ENSG00000147180#ENST00000276123#C2H2 ZF Containing Proteins#Zfx_Zfy_act, zf-C2H2_4, zf-H2C2_5$#ENSP00000353922#ENSG00000147180#ENST00000360700#C2H2 ZF Containing Proteins#Zfx_Zfy_act, zf-C2H2_4, zf-H2C2_5$#ENSP00000362260#ENSG00000147180#ENST00000373165#C2H2 ZF Containing Proteins#Zfx_Zfy_act, zf-C2H2_4, zf-H2C2_5	FALSE
861	ENSG00000178665	ZNF713	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR007087;IPR015880;	349075	zinc finger protein 713 [Source:HGNC Symbol;Acc:HGNC:22043]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000487818#ENSG00000178665#ENST00000633730#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416662#ENSG00000178665#ENST00000429591#C2H2 ZF Containing Proteins#KRAB	TRUE
862	ENSG00000160352	ZNF714	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	148206	Zinc finger protein 714 [Source:HGNC Symbol;Acc:HGNC:27124]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000480816#ENSG00000160352#ENST00000620627#C2H2 ZF Containing Proteins#KRAB$#ENSP00000478345#ENSG00000160352#ENST00000456283#C2H2 ZF Containing Proteins#$#ENSP00000469616#ENSG00000160352#ENST00000596053#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484576#ENSG00000160352#ENST00000618008#C2H2 ZF Containing Proteins#KRAB$#ENSP00000484530#ENSG00000160352#ENST00000618422#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
863	ENSG00000182111	ZNF716	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	441234	zinc finger protein 716 [Source:HGNC Symbol;Acc:HGNC:32458]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000394248#ENSG00000182111#ENST00000420713#C2H2 ZF Containing Proteins#BolA, KRAB, zf-H2C2_2	TRUE
864	ENSG00000227124	ZNF717	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909	100131827	Zinc finger protein 717 [Source:HGNC Symbol;Acc:HGNC:29448]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	$#ENSG00000227124#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000417902#ENSG00000227124#ENST00000477374#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418187#ENSG00000227124#ENST00000468296#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420241#ENSG00000227124#ENST00000471541#C2H2 ZF Containing Proteins#$#ENSP00000419377#ENSG00000227124#ENST00000478296#C2H2 ZF Containing Proteins#	TRUE
865	ENSG00000250312	ZNF718	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001909;IPR007087;IPR015880	255403	zinc finger protein 718 [Source:HGNC Symbol;Acc:HGNC:26889]	None	Full	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000480556#ENSG00000250312#ENST00000510175#C2H2 ZF Containing Proteins#KRAB$#ENSP00000476435#ENSG00000250312#ENST00000609714#C2H2 ZF Containing Proteins#KRAB	FALSE
866	ENSG00000182903	ZNF721	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	170960	zinc finger protein 721 [Source:HGNC Symbol;Acc:HGNC:29425]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000421325#ENSG00000182903#ENST00000505900#C2H2 ZF Containing Proteins#KRAB$#ENSP00000340524#ENSG00000182903#ENST00000338977#C2H2 ZF Containing Proteins#zf-C2H2_6$#ENSP00000423586#ENSG00000182903#ENST00000506646#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428878#ENSG00000182903#ENST00000511833#C2H2 ZF Containing Proteins#zf-C2H2_6	FALSE
867	ENSG00000196081	ZNF724	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain.	IPR001909;IPR007087;IPR015880;	None	zinc finger protein 724, pseudogene [Source:HGNC Symbol;Acc:HGNC:32460]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000413411#ENSG00000196081#ENST00000418100#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471547#ENSG00000196081#ENST00000597037#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473253#ENSG00000196081#ENST00000597537#C2H2 ZF Containing Proteins#KRAB	TRUE
868	ENSG00000213967	ZNF726	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	730087	zinc finger protein 726 [Source:HGNC Symbol;Acc:HGNC:32462]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000213967#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000432583#ENSG00000213967#ENST00000531821#C2H2 ZF Containing Proteins#KRAB$#ENSP00000461349#ENSG00000213967#ENST00000575986#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433319#ENSG00000213967#ENST00000525354#C2H2 ZF Containing Proteins#KRAB$#ENSP00000334762#ENSG00000213967#ENST00000334589#C2H2 ZF Containing Proteins#KRAB	TRUE
869	ENSG00000214652	ZNF727	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001909;IPR007087;IPR015880	442319	zinc finger protein 727 [Source:HGNC Symbol;Acc:HGNC:22785]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000485448#ENSG00000214652#ENST00000456806#C2H2 ZF Containing Proteins#KRAB	TRUE
870	ENSG00000269067	ZNF728	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880	388523	zinc finger protein 728 [Source:HGNC Symbol;Acc:HGNC:32463]	None	not tested	not tested	None	None	No	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000269067#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000470208#ENSG00000269067#ENST00000599851#C2H2 ZF Containing Proteins#$#ENSP00000471593#ENSG00000269067#ENST00000594710#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
871	ENSG00000196350	ZNF729	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	100287226	zinc finger protein 729 [Source:HGNC Symbol;Acc:HGNC:32464]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000469582#ENSG00000196350#ENST00000601693#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
872	ZNF73_HUMAN	ZNF73	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene; Only known motifs are from Transfac or HocoMoco - origin is uncertain	Pseudogene	None	None	zinc finger protein 73	None	not tested	not tested	None	Pseudogene	No	Yes	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
873	ENSG00000183850	ZNF730	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	100129543	zinc finger protein 730 [Source:HGNC Symbol;Acc:HGNC:32470]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000469853#ENSG00000183850#ENST00000593635#C2H2 ZF Containing Proteins#$#ENSP00000472959#ENSG00000183850#ENST00000597761#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469805#ENSG00000183850#ENST00000599195#C2H2 ZF Containing Proteins#	TRUE
874	ENSG00000186777	ZNF732	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	654254	zinc finger protein 732 [Source:HGNC Symbol;Acc:HGNC:37138]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000415774#ENSG00000186777#ENST00000419098#C2H2 ZF Containing Proteins#KRAB$#ENSP00000478210#ENSG00000186777#ENST00000619749#C2H2 ZF Containing Proteins#KRAB	TRUE
875	ENSG00000223614	ZNF735	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001909;IPR007087;IPR015880	730291	zinc finger protein 735 [Source:HGNC Symbol;Acc:HGNC:32466]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000485547#ENSG00000223614#ENST00000429565#C2H2 ZF Containing Proteins#KRAB	TRUE
876	ENSG00000234444	ZNF736	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	728927	zinc finger protein 736 [Source:HGNC Symbol;Acc:HGNC:32467]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000400852#ENSG00000234444#ENST00000423484#C2H2 ZF Containing Proteins#KRAB$#ENSP00000347210#ENSG00000234444#ENST00000355095#C2H2 ZF Containing Proteins#KRAB$#ENSP00000391083#ENSG00000234444#ENST00000438373#C2H2 ZF Containing Proteins#	TRUE
877	ENSG00000237440	ZNF737	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880	100129842	zinc finger protein 737 [Source:HGNC Symbol;Acc:HGNC:32468]	None	not tested	not tested	None	None	No	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000395733#ENSG00000237440#ENST00000427401#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471995#ENSG00000237440#ENST00000596530#C2H2 ZF Containing Proteins#$#ENSP00000471784#ENSG00000237440#ENST00000594419#C2H2 ZF Containing Proteins#$#ENSP00000471973#ENSG00000237440#ENST00000596797#C2H2 ZF Containing Proteins#KRAB	TRUE
878	ENSG00000185252	ZNF74	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	7625	zinc finger protein 74 [Source:HGNC Symbol;Acc:HGNC:13144]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000185252#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000350101#ENSG00000185252#ENST00000357502#C2H2 ZF Containing Proteins#$#ENSP00000383301#ENSG00000185252#ENST00000400451#C2H2 ZF Containing Proteins#KRAB$#ENSP00000384750#ENSG00000185252#ENST00000403682#C2H2 ZF Containing Proteins#$#ENSP00000483077#ENSG00000185252#ENST00000611540#C2H2 ZF Containing Proteins#KRAB	TRUE
879	ENSG00000139651	ZNF740	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	283337	zinc finger protein 740 [Source:HGNC Symbol;Acc:HGNC:27465]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000409463#ENSG00000139651#ENST00000416904#C2H2 ZF Containing Proteins#	FALSE
880	ENSG00000181220	ZNF746	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;IPR022137	155061	zinc finger protein 746 [Source:HGNC Symbol;Acc:HGNC:21948]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000181220#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21376232$#ENSG00000181220#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:21376232	$#ENSP00000345140#ENSG00000181220#ENST00000340622#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000420329#ENSG00000181220#ENST00000461958#C2H2 ZF Containing Proteins#DUF3669, KRAB$#ENSP00000395007#ENSG00000181220#ENST00000458143#C2H2 ZF Containing Proteins#DUF3669, KRAB	TRUE
881	ENSG00000169955	ZNF747	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	65988	zinc finger protein 747 [Source:HGNC Symbol;Acc:HGNC:28350]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000252799#ENSG00000169955#ENST00000252799#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378528#ENSG00000169955#ENST00000395094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000457274#ENSG00000169955#ENST00000568028#C2H2 ZF Containing Proteins#KRAB	TRUE
882	ENSG00000186230	ZNF749	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	388567	zinc finger protein 749 [Source:HGNC Symbol;Acc:HGNC:32783]	None	not tested	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000333980#ENSG00000186230#ENST00000334181#C2H2 ZF Containing Proteins#KRAB$#ENSP00000397745#ENSG00000186230#ENST00000415248#C2H2 ZF Containing Proteins#	TRUE
883	ENSG00000141579	ZNF750	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain; Has a putative AT-hook	Influences KLF4 expression (PMID: 22364861).	None	79755	zinc finger protein 750 [Source:HGNC Symbol;Acc:HGNC:25843]	None	DBD and Full	not tested	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000141579#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22364861	$#ENSP00000269394#ENSG00000141579#ENST00000269394#C2H2 ZF Containing Proteins#zf-C2H2_7$#ENSP00000458389#ENSG00000141579#ENST00000572562#C2H2 ZF Containing Proteins#	FALSE
884	ENSG00000162086	ZNF75A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7627	zinc finger protein 75a [Source:HGNC Symbol;Acc:HGNC:13146]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000482769#ENSG00000162086#ENST00000617839#C2H2 ZF Containing Proteins#KRAB$#ENSP00000459566#ENSG00000162086#ENST00000574298#C2H2 ZF Containing Proteins#KRAB$#ENSP00000459707#ENSG00000162086#ENST00000572999#C2H2 ZF Containing Proteins#KRAB$#ENSP00000483325#ENSG00000162086#ENST00000612186#C2H2 ZF Containing Proteins#SCAN	TRUE
885	ENSG00000186376	ZNF75D	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR003309;IPR007087;IPR008916;IPR015880;	7626	zinc finger protein 75D [Source:HGNC Symbol;Acc:HGNC:13145]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000186376#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000359802#ENSG00000186376#ENST00000370766#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000359800#ENSG00000186376#ENST00000370764#C2H2 ZF Containing Proteins#KRAB, SCAN	TRUE
886	ENSG00000065029	ZNF76	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	7629	zinc finger protein 76 [Source:HGNC Symbol;Acc:HGNC:13149]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	None	$#ENSP00000344097#ENSG00000065029#ENST00000339411#C2H2 ZF Containing Proteins#CopK$#ENSP00000363064#ENSG00000065029#ENST00000373953#C2H2 ZF Containing Proteins#CopK$#ENSP00000418749#ENSG00000065029#ENST00000498555#C2H2 ZF Containing Proteins#$#ENSP00000419106#ENSG00000065029#ENST00000469195#C2H2 ZF Containing Proteins#CopK	FALSE
887	ENSG00000160336	ZNF761	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001909;IPR007087;IPR015880;	388561	zinc finger protein 761 [Source:HGNC Symbol;Acc:HGNC:23179]	None	DBD	not tested	None	None	b	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000160336#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000480218#ENSG00000160336#ENST00000432094#C2H2 ZF Containing Proteins#KRAB$#ENSP00000481316#ENSG00000160336#ENST00000610928#C2H2 ZF Containing Proteins#KRAB$#ENSP00000481271#ENSG00000160336#ENST00000613950#C2H2 ZF Containing Proteins#KRAB$#ENSP00000482214#ENSG00000160336#ENST00000334095#C2H2 ZF Containing Proteins#	FALSE
888	ENSG00000197054	ZNF763	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	284390	zinc finger protein 763 [Source:HGNC Symbol;Acc:HGNC:27614]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000402017#ENSG00000197054#ENST00000358987#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000369774#ENSG00000197054#ENST00000343949#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4, zf-H2C2_2$#ENSP00000468692#ENSG00000197054#ENST00000481745#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465145#ENSG00000197054#ENST00000586494#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6, zf-H2C2_2	TRUE
889	ENSG00000169951	ZNF764	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	92595	zinc finger protein 764 [Source:HGNC Symbol;Acc:HGNC:28200]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000252797#ENSG00000169951#ENST00000252797#C2H2 ZF Containing Proteins#KRAB$#ENSP00000378526#ENSG00000169951#ENST00000395091#C2H2 ZF Containing Proteins#KRAB	TRUE
890	ENSG00000196417	ZNF765	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	91661	zinc finger protein 765 [Source:HGNC Symbol;Acc:HGNC:25092]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000379689#ENSG00000196417#ENST00000396408#C2H2 ZF Containing Proteins#KRAB$#ENSP00000421579#ENSG00000196417#ENST00000505866#C2H2 ZF Containing Proteins#$#ENSP00000470468#ENSG00000196417#ENST00000594030#C2H2 ZF Containing Proteins#KRAB	TRUE
891	ENSG00000196214	ZNF766	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	90321	zinc finger protein 766 [Source:HGNC Symbol;Acc:HGNC:28063]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000409652#ENSG00000196214#ENST00000439461#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468950#ENSG00000196214#ENST00000593612#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_6$#ENSP00000471965#ENSG00000196214#ENST00000599581#C2H2 ZF Containing Proteins#KRAB	TRUE
892	ENSG00000169957	ZNF768	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR000684;IPR007087;IPR015880;	79724	zinc finger protein 768 [Source:HGNC Symbol;Acc:HGNC:26273]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000369777#ENSG00000169957#ENST00000380412#C2H2 ZF Containing Proteins#RNA_pol_Rpb1_R$#ENSP00000456527#ENSG00000169957#ENST00000562803#C2H2 ZF Containing Proteins#RNA_pol_Rpb1_R	FALSE
893	ENSG00000175691	ZNF77	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	58492	zinc finger protein 77 [Source:HGNC Symbol;Acc:HGNC:13150]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000319053#ENSG00000175691#ENST00000314531#C2H2 ZF Containing Proteins#KRAB	TRUE
894	ENSG00000198146	ZNF770	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR007087;IPR015880	54989	zinc finger protein 770 [Source:HGNC Symbol;Acc:HGNC:26061]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000198146#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000348673#ENSG00000198146#ENST00000356321#C2H2 ZF Containing Proteins#$#ENSP00000453474#ENSG00000198146#ENST00000559564#C2H2 ZF Containing Proteins#	FALSE
895	ENSG00000179965	ZNF771	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	51333	zinc finger protein 771 [Source:HGNC Symbol;Acc:HGNC:29653]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	None	$#ENSP00000323945#ENSG00000179965#ENST00000319296#C2H2 ZF Containing Proteins#DNA_RNApol_7kD, Zn-ribbon_8$#ENSP00000460549#ENSG00000179965#ENST00000566625#C2H2 ZF Containing Proteins#$#ENSP00000416197#ENSG00000179965#ENST00000434417#C2H2 ZF Containing Proteins#DNA_RNApol_7kD, Zn-ribbon_8$#ENSP00000456456#ENSG00000179965#ENST00000564550#C2H2 ZF Containing Proteins#	FALSE
896	ENSG00000197128	ZNF772	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	400720	zinc finger protein 772 [Source:HGNC Symbol;Acc:HGNC:33106]	None	Full	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000197128#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000341165#ENSG00000197128#ENST00000343280#C2H2 ZF Containing Proteins#KRAB$#ENSP00000395967#ENSG00000197128#ENST00000427512#C2H2 ZF Containing Proteins#$#ENSP00000348992#ENSG00000197128#ENST00000356584#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415214#ENSG00000197128#ENST00000425074#C2H2 ZF Containing Proteins#$#ENSP00000471079#ENSG00000197128#ENST00000600175#C2H2 ZF Containing Proteins#$#ENSP00000471647#ENSG00000197128#ENST00000601768#C2H2 ZF Containing Proteins#	TRUE
897	ENSG00000152439	ZNF773	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	374928	zinc finger protein 773 [Source:HGNC Symbol;Acc:HGNC:30487]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000152439#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000282292#ENSG00000152439#ENST00000282292#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469416#ENSG00000152439#ENST00000598770#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468846#ENSG00000152439#ENST00000599847#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470189#ENSG00000152439#ENST00000593916#C2H2 ZF Containing Proteins#KRAB	TRUE
898	ENSG00000196391	ZNF774	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR007087;IPR015880	342132	zinc finger protein 774 [Source:HGNC Symbol;Acc:HGNC:33108]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000346348#ENSG00000196391#ENST00000354377#C2H2 ZF Containing Proteins#$#ENSP00000368383#ENSG00000196391#ENST00000379090#C2H2 ZF Containing Proteins#$#ENSP00000454184#ENSG00000196391#ENST00000558586#C2H2 ZF Containing Proteins#	TRUE
899	ENSG00000196456	ZNF775	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a MBD domain	IPR007087;IPR015880	285971	zinc finger protein 775 [Source:HGNC Symbol;Acc:HGNC:28501]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000330838#ENSG00000196456#ENST00000329630#C2H2 ZF Containing Proteins#$#ENSP00000417483#ENSG00000196456#ENST00000490973#C2H2 ZF Containing Proteins#$#ENSP00000489517#ENSG00000196456#ENST00000498682#C2H2 ZF Containing Proteins#$#ENSP00000419336#ENSG00000196456#ENST00000478789#C2H2 ZF Containing Proteins#	FALSE
900	ENSG00000152443	ZNF776	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284309	zinc finger protein 776 [Source:HGNC Symbol;Acc:HGNC:26765]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000321812#ENSG00000152443#ENST00000317178#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416901#ENSG00000152443#ENST00000451849#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405772#ENSG00000152443#ENST00000431353#C2H2 ZF Containing Proteins#KRAB	TRUE
901	ENSG00000196453	ZNF777	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;IPR022137	27153	Zinc finger protein 777 [Source:HGNC Symbol;Acc:HGNC:22213]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000247930#ENSG00000196453#ENST00000247930#C2H2 ZF Containing Proteins#DUF3669, KRAB	TRUE
902	ENSG00000170100	ZNF778	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	197320	zinc finger protein 778 [Source:HGNC Symbol;Acc:HGNC:26479]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000305203#ENSG00000170100#ENST00000306502#C2H2 ZF Containing Proteins#$#ENSP00000481538#ENSG00000170100#ENST00000620195#C2H2 ZF Containing Proteins#KRAB$#ENSP00000457800#ENSG00000170100#ENST00000564906#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405289#ENSG00000170100#ENST00000433976#C2H2 ZF Containing Proteins#KRAB	TRUE
903	ENSG00000197782	ZNF780A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	284323	zinc finger protein 780A [Source:HGNC Symbol;Acc:HGNC:27603]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000197782#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000341507#ENSG00000197782#ENST00000340963#C2H2 ZF Containing Proteins#KRAB$#ENSP00000416294#ENSG00000197782#ENST00000414720#C2H2 ZF Containing Proteins#KRAB$#ENSP00000387705#ENSG00000197782#ENST00000450241#C2H2 ZF Containing Proteins#$#ENSP00000469786#ENSG00000197782#ENST00000594395#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472189#ENSG00000197782#ENST00000595687#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469905#ENSG00000197782#ENST00000599972#C2H2 ZF Containing Proteins#KRAB	TRUE
904	ENSG00000128000	ZNF780B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	163131	zinc finger protein 780B [Source:HGNC Symbol;Acc:HGNC:33109]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Sam Lambert	Yes	$#ENSG00000128000#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000221355#ENSG00000128000#ENST00000221355#C2H2 ZF Containing Proteins#$#ENSP00000471669#ENSG00000128000#ENST00000598845#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471501#ENSG00000128000#ENST00000593605#C2H2 ZF Containing Proteins#KRAB	TRUE
905	ENSG00000196381	ZNF781	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	163115	zinc finger protein 781 [Source:HGNC Symbol;Acc:HGNC:26745]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000351391#ENSG00000196381#ENST00000358582#C2H2 ZF Containing Proteins#$#ENSP00000466370#ENSG00000196381#ENST00000590008#C2H2 ZF Containing Proteins#	FALSE
906	ENSG00000196597	ZNF782	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	158431	zinc finger protein 782 [Source:HGNC Symbol;Acc:HGNC:33110]	None	Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000196597#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000419397#ENSG00000196597#ENST00000481138#C2H2 ZF Containing Proteins#KRAB$#ENSP00000440624#ENSG00000196597#ENST00000535338#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418686#ENSG00000196597#ENST00000289032#C2H2 ZF Containing Proteins#$#ENSP00000417577#ENSG00000196597#ENST00000478850#C2H2 ZF Containing Proteins#KRAB	TRUE
907	ENSG00000204946	ZNF783	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;IPR022137	100289678	zinc finger family member 783 [Source:HGNC Symbol;Acc:HGNC:27222]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000410890#ENSG00000204946#ENST00000434415#C2H2 ZF Containing Proteins#DUF3669, KRAB	TRUE
908	ENSG00000179922	ZNF784	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	147808	zinc finger protein 784 [Source:HGNC Symbol;Acc:HGNC:33111]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000320096#ENSG00000179922#ENST00000325351#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000467725#ENSG00000179922#ENST00000591479#C2H2 ZF Containing Proteins#	FALSE
909	ENSG00000197162	ZNF785	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	146540	zinc finger protein 785 [Source:HGNC Symbol;Acc:HGNC:26496]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000378642#ENSG00000197162#ENST00000395216#C2H2 ZF Containing Proteins#KRAB$#ENSP00000458511#ENSG00000197162#ENST00000567773#C2H2 ZF Containing Proteins#KRAB$#ENSP00000420340#ENSG00000197162#ENST00000470110#C2H2 ZF Containing Proteins#KRAB	TRUE
910	ENSG00000197362	ZNF786	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	136051	zinc finger protein 786 [Source:HGNC Symbol;Acc:HGNC:21806]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000313516#ENSG00000197362#ENST00000316286#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000417470#ENSG00000197362#ENST00000491431#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
911	ENSG00000142409	ZNF787	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	126208	zinc finger protein 787 [Source:HGNC Symbol;Acc:HGNC:26998]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000471514#ENSG00000142409#ENST00000586787#C2H2 ZF Containing Proteins#$#ENSP00000478557#ENSG00000142409#ENST00000610935#C2H2 ZF Containing Proteins#zinc_ribbon_9$#ENSP00000465647#ENSG00000142409#ENST00000587279#C2H2 ZF Containing Proteins#	FALSE
912	ENSG00000214189	ZNF788	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	None	None	Zinc finger family member 788 [Source:HGNC Symbol;Acc:HGNC:33112]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000391703#ENSG00000214189#ENST00000430298#C2H2 ZF Containing Proteins#KRAB$#ENSP00000473243#ENSG00000214189#ENST00000596883#C2H2 ZF Containing Proteins#KRAB$#ENSP00000380866#ENSG00000214189#ENST00000397759#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-C2H2_6	FALSE
913	ENSG00000198556	ZNF789	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	285989	zinc finger protein 789 [Source:HGNC Symbol;Acc:HGNC:27801]	None	Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000198556#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000331927#ENSG00000198556#ENST00000331410#C2H2 ZF Containing Proteins#KRAB$#ENSP00000405206#ENSG00000198556#ENST00000448667#C2H2 ZF Containing Proteins#KRAB$#ENSP00000417227#ENSG00000198556#ENST00000483089#C2H2 ZF Containing Proteins#KRAB$#ENSP00000369047#ENSG00000198556#ENST00000379724#C2H2 ZF Containing Proteins#KRAB	TRUE
914	ENSG00000196152	ZNF79	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7633	zinc finger protein 79 [Source:HGNC Symbol;Acc:HGNC:13153]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000196152#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000362446#ENSG00000196152#ENST00000342483#C2H2 ZF Containing Proteins#$#ENSP00000438418#ENSG00000196152#ENST00000543471#C2H2 ZF Containing Proteins#$#ENSP00000478201#ENSG00000196152#ENST00000612342#C2H2 ZF Containing Proteins#$#ENSP00000484833#ENSG00000196152#ENST00000617266#C2H2 ZF Containing Proteins#	TRUE
915	ENSG00000197863	ZNF790	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	388536	zinc finger protein 790 [Source:HGNC Symbol;Acc:HGNC:33114]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000197863#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000349161#ENSG00000197863#ENST00000356725#C2H2 ZF Containing Proteins#KRAB$#ENSP00000433389#ENSG00000197863#ENST00000525288#C2H2 ZF Containing Proteins#KRAB$#ENSP00000435944#ENSG00000197863#ENST00000528994#C2H2 ZF Containing Proteins#KRAB$#ENSP00000480834#ENSG00000197863#ENST00000614179#C2H2 ZF Containing Proteins#KRAB	TRUE
916	ENSG00000173875	ZNF791	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	163049	zinc finger protein 791 [Source:HGNC Symbol;Acc:HGNC:26895]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000342974#ENSG00000173875#ENST00000343325#C2H2 ZF Containing Proteins#KRAB$#ENSP00000412981#ENSG00000173875#ENST00000446165#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471179#ENSG00000173875#ENST00000600752#C2H2 ZF Containing Proteins#	TRUE
917	ENSG00000180884	ZNF792	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR007087;IPR015880;	126375	zinc finger protein 792 [Source:HGNC Symbol;Acc:HGNC:24751]	None	Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000180884#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000474130#ENSG00000180884#ENST00000605484#C2H2 ZF Containing Proteins#$#ENSP00000385099#ENSG00000180884#ENST00000404801#C2H2 ZF Containing Proteins#KRAB	TRUE
918	ENSG00000188227	ZNF793	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	390927	zinc finger protein 793 [Source:HGNC Symbol;Acc:HGNC:33115]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000188227#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000466645#ENSG00000188227#ENST00000587986#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467919#ENSG00000188227#ENST00000588578#C2H2 ZF Containing Proteins#KRAB$#ENSP00000468286#ENSG00000188227#ENST00000586138#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465900#ENSG00000188227#ENST00000587490#C2H2 ZF Containing Proteins#KRAB	TRUE
919	ENSG00000196466	ZNF799	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	90576	zinc finger protein 799 [Source:HGNC Symbol;Acc:HGNC:28071]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000415278#ENSG00000196466#ENST00000419318#C2H2 ZF Containing Proteins#$#ENSP00000411084#ENSG00000196466#ENST00000430385#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471169#ENSG00000196466#ENST00000595766#C2H2 ZF Containing Proteins#	TRUE
920	ENSG00000278129	ZNF8	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7554	Zinc finger protein 8 [Source:HGNC Symbol;Acc:HGNC:13154]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12370310	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000278129#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000477716#ENSG00000278129#ENST00000621650#C2H2 ZF Containing Proteins#KRAB	TRUE
921	ENSG00000174255	ZNF80	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains.	IPR007087;IPR015880	7634	zinc finger protein 80 [Source:HGNC Symbol;Acc:HGNC:13155]	None	DBD and Full	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000483565#ENSG00000174255#ENST00000619534#C2H2 ZF Containing Proteins#$#ENSP00000417192#ENSG00000174255#ENST00000482457#C2H2 ZF Containing Proteins#	FALSE
922	ENSG00000048405	ZNF800	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	C2H2 domains are not arranged in the stereotypic array fashion; but there are several of them.	IPR007087;IPR015880	168850	zinc finger protein 800 [Source:HGNC Symbol;Acc:HGNC:27267]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Tim Hughes	Sam Lambert	Yes	None	$#ENSP00000265827#ENSG00000048405#ENST00000265827#C2H2 ZF Containing Proteins#zf-C2H2_assoc2, zf-H2C2_2$#ENSP00000389776#ENSG00000048405#ENST00000439506#C2H2 ZF Containing Proteins#$#ENSP00000401109#ENSG00000048405#ENST00000436992#C2H2 ZF Containing Proteins#	FALSE
923	ENSG00000170396	ZNF804A	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;IPR022755	91752	zinc finger protein 804A [Source:HGNC Symbol;Acc:HGNC:21711]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000303252#ENSG00000170396#ENST00000302277#C2H2 ZF Containing Proteins#zf-C2H2_jaz$#ENSP00000483032#ENSG00000170396#ENST00000613975#C2H2 ZF Containing Proteins#	FALSE
924	ENSG00000182348	ZNF804B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Jaz domain suggests RNA-binding activity	IPR007087;IPR022755	219578	zinc finger protein 804B [Source:HGNC Symbol;Acc:HGNC:21958]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000329638#ENSG00000182348#ENST00000333190#C2H2 ZF Containing Proteins#zf-C2H2_jaz$#ENSP00000478506#ENSG00000182348#ENST00000611114#C2H2 ZF Containing Proteins#	FALSE
925	ENSG00000204524	ZNF805	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	390980	zinc finger protein 805 [Source:HGNC Symbol;Acc:HGNC:23272]	None	not tested	not tested	None	None	x	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000365414#ENSG00000204524#ENST00000354309#C2H2 ZF Containing Proteins#$#ENSP00000412999#ENSG00000204524#ENST00000414468#C2H2 ZF Containing Proteins#KRAB	TRUE
926	ENSG00000198482	ZNF808	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	388558	zinc finger protein 808 [Source:HGNC Symbol;Acc:HGNC:33230]	None	Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000198482#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000479648#ENSG00000198482#ENST00000611267#C2H2 ZF Containing Proteins#$#ENSP00000419291#ENSG00000198482#ENST00000465448#C2H2 ZF Containing Proteins#KRAB$#ENSP00000418528#ENSG00000198482#ENST00000486474#C2H2 ZF Containing Proteins#	TRUE
927	ENSG00000197779	ZNF81	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	347344	zinc finger protein 81 [Source:HGNC Symbol;Acc:HGNC:13156]	None	Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000197779#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000334641#ENSG00000197779#ENST00000334937#C2H2 ZF Containing Proteins#KRAB$#ENSP00000341151#ENSG00000197779#ENST00000338637#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366149#ENSG00000197779#ENST00000376950#C2H2 ZF Containing Proteins#KRAB$#ENSP00000366153#ENSG00000197779#ENST00000376954#C2H2 ZF Containing Proteins#KRAB	TRUE
928	ENSG00000224689	ZNF812P	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	None	IPR001909;IPR007087;IPR015880;	None	zinc finger protein 812, pseudogene [Source:HGNC Symbol;Acc:HGNC:33242]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000440451#ENSG00000224689#ENST00000453792#C2H2 ZF Containing Proteins#KRAB	FALSE
929	ENSG00000198346	ZNF813	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of znfC2H2 domains and a KRAB domain	IPR001909;IPR007087;IPR015880;	126017	zinc finger protein 813 [Source:HGNC Symbol;Acc:HGNC:33257]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000379684#ENSG00000198346#ENST00000396403#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000418289#ENSG00000198346#ENST00000490956#C2H2 ZF Containing Proteins#KRAB$#ENSP00000419821#ENSG00000198346#ENST00000468450#C2H2 ZF Containing Proteins#	TRUE
930	ENSG00000204514	ZNF814	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	730051	zinc finger protein 814 [Source:HGNC Symbol;Acc:HGNC:33258]	None	not tested	not tested	None	None	x	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	Yes	$#ENSG00000204514#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000470328#ENSG00000204514#ENST00000596604#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472089#ENSG00000204514#ENST00000600634#C2H2 ZF Containing Proteins#KRAB$#ENSP00000410545#ENSG00000204514#ENST00000435989#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469704#ENSG00000204514#ENST00000595295#C2H2 ZF Containing Proteins#$#ENSP00000469641#ENSG00000204514#ENST00000597807#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469912#ENSG00000204514#ENST00000597832#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470296#ENSG00000204514#ENST00000597342#C2H2 ZF Containing Proteins#KRAB	TRUE
931	ENSG00000180257	ZNF816	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	125893	zinc finger protein 816 [Source:HGNC Symbol;Acc:HGNC:26995]	None	Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000180257#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000350295#ENSG00000180257#ENST00000357666#C2H2 ZF Containing Proteins#KRAB$#ENSP00000403266#ENSG00000180257#ENST00000444460#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472475#ENSG00000180257#ENST00000270457#C2H2 ZF Containing Proteins#KRAB	TRUE
932	ENSG00000102984	ZNF821	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	55565	zinc finger protein 821 [Source:HGNC Symbol;Acc:HGNC:28043]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	No	$#ENSG00000102984#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000313822#ENSG00000102984#ENST00000313565#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_6, zf-met$#ENSP00000405908#ENSG00000102984#ENST00000446827#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_6, zf-met$#ENSP00000458112#ENSG00000102984#ENST00000562797#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-met$#ENSP00000456193#ENSG00000102984#ENST00000565516#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-met$#ENSP00000455648#ENSG00000102984#ENST00000565601#C2H2 ZF Containing Proteins#zf-C2H2_11, zf-C2H2_6, zf-met$#ENSP00000481362#ENSG00000102984#ENST00000611294#C2H2 ZF Containing Proteins#	FALSE
933	ENSG00000197933	ZNF823	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	55552	zinc finger protein 823 [Source:HGNC Symbol;Acc:HGNC:30936]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000340683#ENSG00000197933#ENST00000341191#C2H2 ZF Containing Proteins#KRAB$#ENSP00000410654#ENSG00000197933#ENST00000431998#C2H2 ZF Containing Proteins#$#ENSP00000387514#ENSG00000197933#ENST00000440527#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466840#ENSG00000197933#ENST00000586121#C2H2 ZF Containing Proteins#	TRUE
934	ENSG00000151612	ZNF827	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has been shown to operate on telomeres and recruit the NuRD complex into them (PMID: 25150861).	IPR007087;IPR015880	152485	zinc finger protein 827 [Source:HGNC Symbol;Acc:HGNC:27193]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000421863#ENSG00000151612#ENST00000508784#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000423130#ENSG00000151612#ENST00000513320#C2H2 ZF Containing Proteins#SRP54_N, zf-C2H2_jaz, zf-H2C2_5$#ENSP00000368761#ENSG00000151612#ENST00000379448#C2H2 ZF Containing Proteins#zf-H2C2_5$#ENSP00000424456#ENSG00000151612#ENST00000511659#C2H2 ZF Containing Proteins#zf-H2C2_2, zf-H2C2_5	FALSE
935	ENSG00000185869	ZNF829	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	374899	zinc finger protein 829 [Source:HGNC Symbol;Acc:HGNC:34032]	None	Full	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000185869#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000429266#ENSG00000185869#ENST00000391711#C2H2 ZF Containing Proteins#KRAB$#ENSP00000428679#ENSG00000185869#ENST00000520965#C2H2 ZF Containing Proteins#KRAB	TRUE
936	ENSG00000167766	ZNF83	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR001909;IPR007087;IPR015880;	55769	zinc finger protein 83 [Source:HGNC Symbol;Acc:HGNC:13158]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000167766#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000439681#ENSG00000167766#ENST00000541777#C2H2 ZF Containing Proteins#$#ENSP00000472619#ENSG00000167766#ENST00000597597#C2H2 ZF Containing Proteins#$#ENSP00000445993#ENSG00000167766#ENST00000536937#C2H2 ZF Containing Proteins#$#ENSP00000440713#ENSG00000167766#ENST00000545872#C2H2 ZF Containing Proteins#$#ENSP00000301096#ENSG00000167766#ENST00000301096#C2H2 ZF Containing Proteins#$#ENSP00000472392#ENSG00000167766#ENST00000600714#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471703#ENSG00000167766#ENST00000601257#C2H2 ZF Containing Proteins#KRAB	FALSE
937	ENSG00000198783	ZNF830	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	Possible false positive. The C2H2 domain is a weak match, and doesnt come up on SMART or PFAM.  Mouse ortholog is involved in DNA replication and repair (PMID: 25168238; PMID: 21191184).	IPR003604;	91603	zinc finger protein 830 [Source:HGNC Symbol;Acc:HGNC:28291]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000354518#ENSG00000198783#ENST00000361952#Other#zf-C2H2_jaz, zf-met	FALSE
938	ENSG00000124203	ZNF831	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	128611	zinc finger protein 831 [Source:HGNC Symbol;Acc:HGNC:16167]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	No	$#ENSG00000124203#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000360069#ENSG00000124203#ENST00000371030#C2H2 ZF Containing Proteins#$#ENSP00000490240#ENSG00000124203#ENST00000637017#C2H2 ZF Containing Proteins#	FALSE
939	ENSG00000127903	ZNF835	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	90485	zinc finger protein 835 [Source:HGNC Symbol;Acc:HGNC:34332]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000127903#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000444747#ENSG00000127903#ENST00000537055#C2H2 ZF Containing Proteins#$#ENSP00000470133#ENSG00000127903#ENST00000601659#C2H2 ZF Containing Proteins#	FALSE
940	ENSG00000196267	ZNF836	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	162962	zinc finger protein 836 [Source:HGNC Symbol;Acc:HGNC:34333]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000196267#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000472008#ENSG00000196267#ENST00000597065#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470239#ENSG00000196267#ENST00000597252#C2H2 ZF Containing Proteins#KRAB$#ENSP00000325038#ENSG00000196267#ENST00000322146#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470043#ENSG00000196267#ENST00000596428#C2H2 ZF Containing Proteins#KRAB	TRUE
941	ENSG00000152475	ZNF837	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a nice cassette of znfC2H2 domains; virtually nothing is known about it otherwise.	IPR007087;IPR015880	116412	zinc finger protein 837 [Source:HGNC Symbol;Acc:HGNC:25164]	None	Full	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000152475#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000405699#ENSG00000152475#ENST00000427624#C2H2 ZF Containing Proteins#Zn-ribbon_8$#ENSP00000471478#ENSG00000152475#ENST00000597582#C2H2 ZF Containing Proteins#Zn-ribbon_8	FALSE
942	ENSG00000022976	ZNF839	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The single C2H2 domain has an insertion between the Hs.  Also; it is embedded within the DUF4764 domain; which encompasses most of the protein.  Its not located in the usual C2H2 loci.	IPR007087;	55778	zinc finger protein 839 [Source:HGNC Symbol;Acc:HGNC:20345]	None	DBD	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$#ENSP00000452819#ENSG00000022976#ENST00000558490#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453363#ENSG00000022976#ENST00000558850#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453415#ENSG00000022976#ENST00000559155#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453109#ENSG00000022976#ENST00000559185#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453137#ENSG00000022976#ENST00000561251#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000454159#ENSG00000022976#ENST00000558462#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000453744#ENSG00000022976#ENST00000560112#C2H2 ZF Containing Proteins#DUF4764$#ENSP00000452983#ENSG00000022976#ENST00000560568#C2H2 ZF Containing Proteins#DUF4764	FALSE
943	ENSG00000198040	ZNF84	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7637	zinc finger protein 84 [Source:HGNC Symbol;Acc:HGNC:13159]	None	Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000331465#ENSG00000198040#ENST00000327668#C2H2 ZF Containing Proteins#KRAB$#ENSP00000376133#ENSG00000198040#ENST00000392319#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445549#ENSG00000198040#ENST00000539354#C2H2 ZF Containing Proteins#KRAB$#ENSP00000445820#ENSG00000198040#ENST00000540031#C2H2 ZF Containing Proteins#KRAB$#ENSP00000387416#ENSG00000198040#ENST00000438628#C2H2 ZF Containing Proteins#KRAB$#ENSP00000437636#ENSG00000198040#ENST00000545299#C2H2 ZF Containing Proteins#	TRUE
944	ENSG00000197608	ZNF841	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	284371	zinc finger protein 841 [Source:HGNC Symbol;Acc:HGNC:27611]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000197608#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000374185#ENSG00000197608#ENST00000389534#C2H2 ZF Containing Proteins#KRAB$#ENSP00000415453#ENSG00000197608#ENST00000426391#C2H2 ZF Containing Proteins#$#ENSP00000470746#ENSG00000197608#ENST00000594295#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470100#ENSG00000197608#ENST00000594440#C2H2 ZF Containing Proteins#KRAB	FALSE
945	ENSG00000176723	ZNF843	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Single C2H2 domain	None	IPR007087;	283933	zinc finger protein 843 [Source:HGNC Symbol;Acc:HGNC:28710]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	No	None	$#ENSP00000483573#ENSG00000176723#ENST00000618063#C2H2 ZF Containing Proteins#$#ENSP00000322899#ENSG00000176723#ENST00000315678#C2H2 ZF Containing Proteins#$#ENSP00000455858#ENSG00000176723#ENST00000564218#C2H2 ZF Containing Proteins#	FALSE
946	ENSG00000223547	ZNF844	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	284391	zinc finger protein 844 [Source:HGNC Symbol;Acc:HGNC:25932]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000392024#ENSG00000223547#ENST00000439326#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_4$#ENSP00000402097#ENSG00000223547#ENST00000441304#C2H2 ZF Containing Proteins#KRAB$#ENSP00000448588#ENSG00000223547#ENST00000550826#C2H2 ZF Containing Proteins#zf-C2H2_4	TRUE
947	ENSG00000213799	ZNF845	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	91664	Zinc finger protein 845 [Source:HGNC Symbol;Acc:HGNC:25112]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000388311#ENSG00000213799#ENST00000458035#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470005#ENSG00000213799#ENST00000595091#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472689#ENSG00000213799#ENST00000601857#C2H2 ZF Containing Proteins#KRAB	TRUE
948	ENSG00000196605	ZNF846	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR001909;IPR003656;IPR007087;IPR015880	162993	zinc finger protein 846 [Source:HGNC Symbol;Acc:HGNC:27260]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000380999#ENSG00000196605#ENST00000397902#C2H2 ZF Containing Proteins#KRAB$#ENSP00000466236#ENSG00000196605#ENST00000586293#C2H2 ZF Containing Proteins#KRAB$#ENSP00000465467#ENSG00000196605#ENST00000588267#C2H2 ZF Containing Proteins#$#ENSP00000467891#ENSG00000196605#ENST00000592859#C2H2 ZF Containing Proteins#	TRUE
949	ENSG00000105750	ZNF85	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	7639	zinc finger protein 85 [Source:HGNC Symbol;Acc:HGNC:13160]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000105750#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9839802	$#ENSP00000300540#ENSG00000105750#ENST00000300540#C2H2 ZF Containing Proteins#KRAB$#ENSP00000329793#ENSG00000105750#ENST00000328178#C2H2 ZF Containing Proteins#KRAB$#ENSP00000469496#ENSG00000105750#ENST00000596476#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472145#ENSG00000105750#ENST00000596534#C2H2 ZF Containing Proteins#$#ENSP00000469673#ENSG00000105750#ENST00000595742#C2H2 ZF Containing Proteins#$#ENSP00000471588#ENSG00000105750#ENST00000599064#C2H2 ZF Containing Proteins#$#ENSP00000470347#ENSG00000105750#ENST00000601284#C2H2 ZF Containing Proteins#KRAB	TRUE
950	ENSG00000267041	ZNF850	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880	342892	zinc finger protein 850 [Source:HGNC Symbol;Acc:HGNC:27994]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000464976#ENSG00000267041#ENST00000591344#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000483509#ENSG00000267041#ENST00000614887#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000465189#ENSG00000267041#ENST00000589390#C2H2 ZF Containing Proteins#KRAB	TRUE
951	ENSG00000178917	ZNF852	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	285346	zinc finger protein 852 [Source:HGNC Symbol;Acc:HGNC:27713]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000389841#ENSG00000178917#ENST00000436261#C2H2 ZF Containing Proteins#KRAB	TRUE
952	ENSG00000236609	ZNF853	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains	IPR007087;IPR015880	54753	zinc finger protein 853 [Source:HGNC Symbol;Acc:HGNC:21767]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000455585#ENSG00000236609#ENST00000457543#C2H2 ZF Containing Proteins#	FALSE
953	ENSG00000197385	ZNF860	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	344787	zinc finger protein 860 [Source:HGNC Symbol;Acc:HGNC:34513]	None	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000373274#ENSG00000197385#ENST00000360311#C2H2 ZF Containing Proteins#KRAB	TRUE
954	ENSG00000261221	ZNF865	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	100507290	zinc finger protein 865 [Source:HGNC Symbol;Acc:HGNC:38705]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000457715#ENSG00000261221#ENST00000568956#C2H2 ZF Containing Proteins#$#ENSP00000487098#ENSG00000261221#ENST00000630143#C2H2 ZF Containing Proteins#	FALSE
955	ENSG00000257446	ZNF878	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	729747	zinc finger protein 878 [Source:HGNC Symbol;Acc:HGNC:37246]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000447931#ENSG00000257446#ENST00000547628#C2H2 ZF Containing Proteins#KRAB	TRUE
956	ENSG00000234284	ZNF879	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	345462	zinc finger protein 879 [Source:HGNC Symbol;Acc:HGNC:37273]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000234284#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000414887#ENSG00000234284#ENST00000444149#C2H2 ZF Containing Proteins#KRAB$#ENSP00000430047#ENSG00000234284#ENST00000519896#C2H2 ZF Containing Proteins#$#ENSP00000428477#ENSG00000234284#ENST00000522442#C2H2 ZF Containing Proteins#KRAB$#ENSP00000431043#ENSG00000234284#ENST00000521285#C2H2 ZF Containing Proteins#KRAB	TRUE
957	ENSG00000221923	ZNF880	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	400713	zinc finger protein 880 [Source:HGNC Symbol;Acc:HGNC:37249]	None	not tested	not tested	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000221923#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000343625#ENSG00000221923#ENST00000344085#C2H2 ZF Containing Proteins#KRAB$#ENSP00000406318#ENSG00000221923#ENST00000422689#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471324#ENSG00000221923#ENST00000597976#C2H2 ZF Containing Proteins#KRAB$#ENSP00000471067#ENSG00000221923#ENST00000600321#C2H2 ZF Containing Proteins#KRAB	TRUE
958	ENSG00000228623	ZNF883	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR007087;	169834	zinc finger protein 883 [Source:HGNC Symbol;Acc:HGNC:27271]	None	not tested	not tested	None	None	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000228623#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000490059#ENSG00000228623#ENST00000619044#C2H2 ZF Containing Proteins#	FALSE
959	ENSG00000213793	ZNF888	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	One transcript is protein-coding	None	None	Zinc finger protein 888	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000213793#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000213793##Other#	FALSE
960	ENSG00000214029	ZNF891	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	101060200	zinc finger protein 891 [Source:HGNC Symbol;Acc:HGNC:38709]	None	not tested	not tested	None	None	x	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000437590#ENSG00000214029#ENST00000537226#C2H2 ZF Containing Proteins#KRAB	TRUE
961	ENSG00000213988	ZNF90	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR000754;IPR001909;IPR007087;IPR015880;IPR020568	7643	zinc finger protein 90 [Source:HGNC Symbol;Acc:HGNC:13165]	None	Full	not tested	None	None	No	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000213988#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:2023909	$#ENSP00000410466#ENSG00000213988#ENST00000418063#C2H2 ZF Containing Proteins#KRAB$#ENSP00000482310#ENSG00000213988#ENST00000434475#C2H2 ZF Containing Proteins#Ribosomal_S9	TRUE
962	ENSG00000167232	ZNF91	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7644	zinc finger protein 91 [Source:HGNC Symbol;Acc:HGNC:13166]	None	not tested	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000167232#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:25274305 | NAS - PMID:2023909	$#ENSP00000300619#ENSG00000167232#ENST00000300619#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_jaz, zf-H2C2_2$#ENSP00000380272#ENSG00000167232#ENST00000397082#C2H2 ZF Containing Proteins#KRAB, zf-C2H2_jaz, zf-H2C2_2$#ENSP00000471709#ENSG00000167232#ENST00000595533#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000468867#ENSG00000167232#ENST00000599743#C2H2 ZF Containing Proteins#KRAB	TRUE
963	ENSG00000146757	ZNF92	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a KRAB-domain	IPR001909;IPR007087;IPR015880;	168374	zinc finger protein 92 [Source:HGNC Symbol;Acc:HGNC:13168]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000146757#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:2023909	$#ENSP00000332595#ENSG00000146757#ENST00000328747#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000350113#ENSG00000146757#ENST00000357512#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000400495#ENSG00000146757#ENST00000431504#C2H2 ZF Containing Proteins#zf-H2C2_2$#ENSP00000396126#ENSG00000146757#ENST00000450302#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
964	ENSG00000184635	ZNF93	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	Kruppel family C2H2 ZF.	IPR001909;IPR007087;IPR015880;	81931	zinc finger protein 93 [Source:HGNC Symbol;Acc:HGNC:13169]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000342002#ENSG00000184635#ENST00000343769#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467377#ENSG00000184635#ENST00000592160#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467652#ENSG00000184635#ENST00000591366#C2H2 ZF Containing Proteins#KRAB$#ENSP00000467553#ENSG00000184635#ENST00000588146#C2H2 ZF Containing Proteins#zf-H2C2_2	TRUE
965	ENSG00000197360	ZNF98	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR001909;IPR007087;IPR015880;	148198	zinc finger protein 98 [Source:HGNC Symbol;Acc:HGNC:13174]	None	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000350418#ENSG00000197360#ENST00000357774#C2H2 ZF Containing Proteins#KRAB$#ENSP00000472301#ENSG00000197360#ENST00000593802#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470558#ENSG00000197360#ENST00000601553#C2H2 ZF Containing Proteins#KRAB$#ENSP00000470736#ENSG00000197360#ENST00000593657#C2H2 ZF Containing Proteins#ISK_Channel, KRAB	TRUE
966	ENSG00000213973	ZNF99	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001909;IPR007087;IPR015880;	7652	zinc finger protein 99 [Source:HGNC Symbol;Acc:HGNC:13175]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000380293#ENSG00000213973#ENST00000397104#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2$#ENSP00000472969#ENSG00000213973#ENST00000596209#C2H2 ZF Containing Proteins#KRAB, zf-H2C2_2	TRUE
967	ENSG00000152467	ZSCAN1	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	284312	zinc finger and SCAN domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23712]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000152467#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000375581#ENSG00000152467#ENST00000391700#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470438#ENSG00000152467#ENST00000601162#C2H2 ZF Containing Proteins#SCAN$#ENSP00000282326#ENSG00000152467#ENST00000282326#C2H2 ZF Containing Proteins#SCAN	FALSE
968	ENSG00000130182	ZSCAN10	C2H2 ZF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	84891	zinc finger and SCAN domain containing 10 [Source:HGNC Symbol;Acc:HGNC:12997]	None	not tested	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000130182#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000252463#ENSG00000130182#ENST00000252463#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459520#ENSG00000130182#ENST00000575108#C2H2 ZF Containing Proteins#$#ENSP00000460473#ENSG00000130182#ENST00000572431#C2H2 ZF Containing Proteins#$#ENSP00000461871#ENSG00000130182#ENST00000572548#C2H2 ZF Containing Proteins#SCAN$#ENSP00000458260#ENSG00000130182#ENST00000576483#C2H2 ZF Containing Proteins#SCAN	FALSE
969	ENSG00000158691	ZSCAN12	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain	IPR003309;IPR007087;IPR008916;IPR015880	9753	zinc finger and SCAN domain containing 12 [Source:HGNC Symbol;Acc:HGNC:13172]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000158691#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000354305#ENSG00000158691#ENST00000361028#C2H2 ZF Containing Proteins#SCAN$#ENSP00000380039#ENSG00000158691#ENST00000396827#C2H2 ZF Containing Proteins#SCAN	FALSE
970	ENSG00000196812	ZSCAN16	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	80345	zinc finger and SCAN domain containing 16 [Source:HGNC Symbol;Acc:HGNC:20813]	None	DBD and Full	not tested	None	There is also a model in the Cell2013 paper but it has outdated symbol ZNF435	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000196812#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366527#ENSG00000196812#ENST00000340487#C2H2 ZF Containing Proteins#SCAN	FALSE
971	ENSG00000121413	ZSCAN18	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003309;IPR007087;IPR008916;IPR015880	65982	zinc finger and SCAN domain containing 18 [Source:HGNC Symbol;Acc:HGNC:21037]	None	DBD	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Tim Hughes	No	$#ENSG00000121413#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000240727#ENSG00000121413#ENST00000240727#C2H2 ZF Containing Proteins#SCAN$#ENSP00000412253#ENSG00000121413#ENST00000433686#C2H2 ZF Containing Proteins#$#ENSP00000468934#ENSG00000121413#ENST00000601144#C2H2 ZF Containing Proteins#SCAN$#ENSP00000471570#ENSG00000121413#ENST00000595944#C2H2 ZF Containing Proteins#$#ENSP00000470123#ENSG00000121413#ENST00000600404#C2H2 ZF Containing Proteins#SCAN$#ENSP00000472129#ENSG00000121413#ENST00000600845#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470329#ENSG00000121413#ENST00000600522#C2H2 ZF Containing Proteins#$#ENSP00000473019#ENSG00000121413#ENST00000600897#C2H2 ZF Containing Proteins#SCAN	FALSE
972	ENSG00000176371	ZSCAN2	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain	IPR003309;IPR007087;IPR008916;IPR015880	54993	zinc finger and SCAN domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20994]	None	Full	not tested	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000176371#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000325123#ENSG00000176371#ENST00000327179#C2H2 ZF Containing Proteins#SCAN$#ENSP00000333895#ENSG00000176371#ENST00000334141#C2H2 ZF Containing Proteins#SCAN$#ENSP00000368663#ENSG00000176371#ENST00000379358#C2H2 ZF Containing Proteins#SCAN$#ENSP00000440004#ENSG00000176371#ENST00000485222#C2H2 ZF Containing Proteins#SCAN$#ENSP00000439132#ENSG00000176371#ENST00000538076#C2H2 ZF Containing Proteins#SCAN$#ENSP00000441342#ENSG00000176371#ENST00000541040#C2H2 ZF Containing Proteins#SCAN$#ENSP00000351257#ENSG00000176371#ENST00000358472#C2H2 ZF Containing Proteins#$#ENSP00000445451#ENSG00000176371#ENST00000546148#C2H2 ZF Containing Proteins#SCAN	FALSE
973	ENSG00000121903	ZSCAN20	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001005;IPR003309;IPR007087;IPR008916;IPR015880;	7579	zinc finger and SCAN domain containing 20 [Source:HGNC Symbol;Acc:HGNC:13093]	None	Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000121903#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000362512#ENSG00000121903#ENST00000373413#C2H2 ZF Containing Proteins#Myb_DNA-bind_4, SCAN$#ENSP00000355053#ENSG00000121903#ENST00000361328#C2H2 ZF Containing Proteins#SCAN	FALSE
974	ENSG00000166529	ZSCAN21	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds AGYACNNNNNNNGGYAC consensus based on SELEX (PMID: 8625807).	IPR003309;IPR007087;IPR008916;IPR015880	7589	zinc finger and SCAN domain containing 21 [Source:HGNC Symbol;Acc:HGNC:13104]	None	Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8625807;10431235	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000166529#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19549071	$#ENSP00000292450#ENSG00000166529#ENST00000292450#C2H2 ZF Containing Proteins#SCAN$#ENSP00000404207#ENSG00000166529#ENST00000438937#C2H2 ZF Containing Proteins#SCAN$#ENSP00000441212#ENSG00000166529#ENST00000543588#C2H2 ZF Containing Proteins#SCAN$#ENSP00000390960#ENSG00000166529#ENST00000456748#C2H2 ZF Containing Proteins#SCAN	FALSE
975	ENSG00000182318	ZSCAN22	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR003309;IPR007087;IPR008916;IPR015880	342945	zinc finger and SCAN domain containing 22 [Source:HGNC Symbol;Acc:HGNC:4929]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000182318#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000332433#ENSG00000182318#ENST00000329665#C2H2 ZF Containing Proteins#SCAN	FALSE
976	ENSG00000187987	ZSCAN23	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	222696	zinc finger and SCAN domain containing 23 [Source:HGNC Symbol;Acc:HGNC:21193]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000187987#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000289788#ENSG00000187987#ENST00000289788#C2H2 ZF Containing Proteins#SCAN	FALSE
977	ENSG00000197037	ZSCAN25	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and a SCAN-domain	IPR003309;IPR007087;IPR008916;IPR015880	221785	zinc finger and SCAN domain containing 25 [Source:HGNC Symbol;Acc:HGNC:21961]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000197037#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000262941#ENSG00000197037#ENST00000262941#C2H2 ZF Containing Proteins#SCAN$#ENSP00000334800#ENSG00000197037#ENST00000334715#C2H2 ZF Containing Proteins#KRAB, SCAN$#ENSP00000413144#ENSG00000197037#ENST00000431485#C2H2 ZF Containing Proteins#SCAN$#ENSP00000377708#ENSG00000197037#ENST00000394152#C2H2 ZF Containing Proteins#KRAB, SCAN	FALSE
978	ENSG00000197062	ZSCAN26	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR003309;IPR007087;IPR008916;IPR015880	7741	zinc finger and SCAN domain containing 26 [Source:HGNC Symbol;Acc:HGNC:12978]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000197062#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | NAS - PMID:1569959	$#ENSP00000484931#ENSG00000197062#ENST00000316606#C2H2 ZF Containing Proteins#$#ENSP00000481707#ENSG00000197062#ENST00000421553#C2H2 ZF Containing Proteins#SCAN$#ENSP00000478769#ENSG00000197062#ENST00000611552#C2H2 ZF Containing Proteins#$#ENSP00000481024#ENSG00000197062#ENST00000617168#C2H2 ZF Containing Proteins#SCAN$#ENSP00000484018#ENSG00000197062#ENST00000619937#C2H2 ZF Containing Proteins#SCAN$#ENSP00000479314#ENSG00000197062#ENST00000614088#C2H2 ZF Containing Proteins#$#ENSP00000485228#ENSG00000197062#ENST00000623276#C2H2 ZF Containing Proteins#SCAN	FALSE
979	ENSG00000140265	ZSCAN29	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR003309;IPR007087;IPR008916;IPR015880	146050	zinc finger and SCAN domain containing 29 [Source:HGNC Symbol;Acc:HGNC:26673]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000140265#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000380174#ENSG00000140265#ENST00000396976#C2H2 ZF Containing Proteins#SCAN$#ENSP00000456089#ENSG00000140265#ENST00000562072#C2H2 ZF Containing Proteins#SCAN$#ENSP00000456883#ENSG00000140265#ENST00000568898#C2H2 ZF Containing Proteins#SCAN$#ENSP00000454548#ENSG00000140265#ENST00000570181#C2H2 ZF Containing Proteins#Myb_DNA-bind_4, SCAN$#ENSP00000458119#ENSG00000140265#ENST00000561661#C2H2 ZF Containing Proteins#	FALSE
980	ENSG00000186814	ZSCAN30	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR003309;IPR007087;IPR008916;IPR015880	100101467	zinc finger and SCAN domain containing 30 [Source:HGNC Symbol;Acc:HGNC:33517]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000186814#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000329738#ENSG00000186814#ENST00000333206#C2H2 ZF Containing Proteins#SCAN$#ENSP00000392371#ENSG00000186814#ENST00000420878#C2H2 ZF Containing Proteins#SCAN$#ENSP00000470677#ENSG00000186814#ENST00000588448#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465046#ENSG00000186814#ENST00000589178#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468180#ENSG00000186814#ENST00000592598#C2H2 ZF Containing Proteins#SCAN	FALSE
981	ENSG00000235109	ZSCAN31	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	Also known as ZNF323	IPR003309;IPR007087;IPR008916;IPR015880	64288	zinc finger and SCAN domain containing 31 [Source:HGNC Symbol;Acc:HGNC:14097]	None	Full	not tested	None	Vaquerizas paper and the Methylpaper are using old symbol ZNF323	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000235109#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000345339#ENSG00000235109#ENST00000344279#C2H2 ZF Containing Proteins#SCAN$#ENSP00000380050#ENSG00000235109#ENST00000396838#C2H2 ZF Containing Proteins#SCAN$#ENSP00000413705#ENSG00000235109#ENST00000439158#C2H2 ZF Containing Proteins#SCAN$#ENSP00000402937#ENSG00000235109#ENST00000446474#C2H2 ZF Containing Proteins#$#ENSP00000390076#ENSG00000235109#ENST00000414429#C2H2 ZF Containing Proteins#SCAN$#ENSP00000391235#ENSG00000235109#ENST00000435857#C2H2 ZF Containing Proteins#$#ENSP00000416225#ENSG00000235109#ENST00000434036#C2H2 ZF Containing Proteins#SCAN$#ENSP00000412519#ENSG00000235109#ENST00000439636#C2H2 ZF Containing Proteins#SCAN$#ENSP00000411033#ENSG00000235109#ENST00000446222#C2H2 ZF Containing Proteins#SCAN$#ENSP00000416108#ENSG00000235109#ENST00000447021#C2H2 ZF Containing Proteins#SCAN$#ENSP00000389479#ENSG00000235109#ENST00000453745#C2H2 ZF Containing Proteins#SCAN	FALSE
982	ENSG00000140987	ZSCAN32	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003309;IPR007087;IPR008916;IPR015880	54925	zinc finger and SCAN domain containing 32 [Source:HGNC Symbol;Acc:HGNC:20812]	None	Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000140987#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000302502#ENSG00000140987#ENST00000304926#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4$#ENSP00000380057#ENSG00000140987#ENST00000396846#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000380061#ENSG00000140987#ENST00000396852#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000460487#ENSG00000140987#ENST00000573327#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000407312#ENSG00000140987#ENST00000422427#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4$#ENSP00000391787#ENSG00000140987#ENST00000439568#C2H2 ZF Containing Proteins#Myb_DNA-bind_4$#ENSP00000459772#ENSG00000140987#ENST00000574940#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4, SCAN$#ENSP00000483210#ENSG00000140987#ENST00000618425#C2H2 ZF Containing Proteins#Myb_DNA-bind_4$#ENSP00000460833#ENSG00000140987#ENST00000573719#C2H2 ZF Containing Proteins#SCAN$#ENSP00000459960#ENSG00000140987#ENST00000573830#C2H2 ZF Containing Proteins#Myb_DNA-bind_4$#ENSP00000458899#ENSG00000140987#ENST00000575350#C2H2 ZF Containing Proteins#KRAB, Myb_DNA-bind_4	TRUE
983	ENSG00000180532	ZSCAN4	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	201516	zinc finger and SCAN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23709]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000180532#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000321963#ENSG00000180532#ENST00000318203#C2H2 ZF Containing Proteins#SCAN$#ENSP00000480210#ENSG00000180532#ENST00000612521#C2H2 ZF Containing Proteins#SCAN	FALSE
984	ENSG00000131848	ZSCAN5A	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	79149	zinc finger and SCAN domain containing 5A [Source:HGNC Symbol;Acc:HGNC:23710]	None	DBD and Full	not tested	None	MethylPaper_Yin2016 PWM has outdated symbol ZSCAN5	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000131848#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000375593#ENSG00000131848#ENST00000391713#C2H2 ZF Containing Proteins#SCAN$#ENSP00000467631#ENSG00000131848#ENST00000587340#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466445#ENSG00000131848#ENST00000587492#C2H2 ZF Containing Proteins#$#ENSP00000467238#ENSG00000131848#ENST00000592355#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468797#ENSG00000131848#ENST00000592509#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466830#ENSG00000131848#ENST00000592679#C2H2 ZF Containing Proteins#	FALSE
985	ENSG00000197213	ZSCAN5B	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003309;IPR007087;IPR008916;IPR015880	342933	zinc finger and SCAN domain containing 5B [Source:HGNC Symbol;Acc:HGNC:34246]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000197213#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000351883#ENSG00000197213#ENST00000358992#C2H2 ZF Containing Proteins#SCAN$#ENSP00000466072#ENSG00000197213#ENST00000586855#C2H2 ZF Containing Proteins#SCAN$#ENSP00000468660#ENSG00000197213#ENST00000587032#C2H2 ZF Containing Proteins#SCAN$#ENSP00000465118#ENSG00000197213#ENST00000589938#C2H2 ZF Containing Proteins#SCAN	FALSE
986	ENSG00000204532	ZSCAN5C	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	ChIP-seq motif is consistent with recognition code (RCADE)	None	IPR003309;IPR007087;IPR008916;IPR015880	None	zinc finger and SCAN domain containing 5C, pseudogene [Source:HGNC Symbol;Acc:HGNC:34294]	None	not tested	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000204532#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000365443#ENSG00000204532#ENST00000376267#C2H2 ZF Containing Proteins#SCAN$#ENSP00000435234#ENSG00000204532#ENST00000534327#C2H2 ZF Containing Proteins#SCAN	FALSE
987	ENSG00000267908	ZSCAN5DP	C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	None	None	None	Putative zinc finger and SCAN domain-containing protein 5D	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000267908#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000267908##Other#	FALSE
988	ENSG00000137185	ZSCAN9	C2H2 ZF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003309;IPR007087;IPR008916;IPR015880	7746	zinc finger and SCAN domain containing 9 [Source:HGNC Symbol;Acc:HGNC:12984]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000137185#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000252207#ENSG00000137185#ENST00000252207#C2H2 ZF Containing Proteins#SCAN$#ENSP00000404074#ENSG00000137185#ENST00000425468#C2H2 ZF Containing Proteins#SCAN$#ENSP00000476254#ENSG00000137185#ENST00000526391#C2H2 ZF Containing Proteins#SCAN$#ENSP00000433468#ENSG00000137185#ENST00000527436#C2H2 ZF Containing Proteins#SCAN$#ENSP00000433402#ENSG00000137185#ENST00000531979#C2H2 ZF Containing Proteins#SCAN	FALSE
989	ENSG00000153975	ZUFSP	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR012462;IPR015880;	221302	zinc finger with UFM1 specific peptidase domain [Source:HGNC Symbol;Acc:HGNC:21224]	None	not tested	Yes	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000357565#ENSG00000153975#ENST00000368576#C2H2 ZF Containing Proteins#Peptidase_C54, Peptidase_C78, zf-C2H2_4, zf-Di19$#ENSP00000357562#ENSG00000153975#ENST00000368573#C2H2 ZF Containing Proteins#zf-Di19	FALSE
990	ENSG00000198205	ZXDA	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Complexes with CIITA and the similar protein ZXDC to regulate MHCII complex transcription (PMID: 17493635).	IPR007087;IPR015880	7789	zinc finger, X-linked, duplicated A [Source:HGNC Symbol;Acc:HGNC:13198]	None	not tested	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000198205#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:17493635	$#ENSP00000351530#ENSG00000198205#ENST00000358697#C2H2 ZF Containing Proteins#	FALSE
991	ENSG00000198455	ZXDB	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	158586	zinc finger, X-linked, duplicated B [Source:HGNC Symbol;Acc:HGNC:13199]	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	Yes	None	$#ENSP00000364023#ENSG00000198455#ENST00000374888#C2H2 ZF Containing Proteins#	FALSE
992	ENSG00000070476	ZXDC	C2H2 ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR007087;IPR015880	79364	ZXD family zinc finger C [Source:HGNC Symbol;Acc:HGNC:28160]	None	Full	Yes	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000070476#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:17493635	$#ENSP00000337694#ENSG00000070476#ENST00000336332#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000374359#ENSG00000070476#ENST00000389709#C2H2 ZF Containing Proteins#zf-C2H2_4	FALSE
993	ENSG00000100105	PATZ1	C2H2 ZF; AT hook	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect	None	IPR000210;IPR000637;IPR007087;IPR011333;IPR013069;IPR015880	23598	POZ/BTB and AT hook containing zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13071]	None	Full	not tested	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:10669750	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000215919#ENSG00000100105#ENST00000215919#C2H2 ZF Containing Proteins#BTB$#ENSP00000266269#ENSG00000100105#ENST00000266269#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_assoc3$#ENSP00000337520#ENSG00000100105#ENST00000351933#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-C2H2_assoc3, zf-Di19$#ENSP00000384173#ENSG00000100105#ENST00000405309#C2H2 ZF Containing Proteins#BTB, zf-C2H2_4, zf-Di19	FALSE
994	ENSG00000112365	ZBTB24	C2H2 ZF; AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000210;IPR007087;IPR011333;IPR013069;IPR015880;	9841	zinc finger and BTB domain containing 24 [Source:HGNC Symbol;Acc:HGNC:21143]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000230122#ENSG00000112365#ENST00000230122#C2H2 ZF Containing Proteins#BTB	FALSE
995	ENSG00000171443	ZNF524	C2H2 ZF; AT hook	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007087;IPR015880	147807	zinc finger protein 524 [Source:HGNC Symbol;Acc:HGNC:28322]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000301073#ENSG00000171443#ENST00000301073#C2H2 ZF Containing Proteins#$#ENSP00000467175#ENSG00000171443#ENST00000589521#C2H2 ZF Containing Proteins#$#ENSP00000466907#ENSG00000171443#ENST00000591046#C2H2 ZF Containing Proteins#	FALSE
996	ENSG00000161914	ZNF653	C2H2 ZF; AT hook	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007087;IPR015880	115950	zinc finger protein 653 [Source:HGNC Symbol;Acc:HGNC:25196]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000293771#ENSG00000161914#ENST00000293771#C2H2 ZF Containing Proteins#$#ENSP00000465166#ENSG00000161914#ENST00000590296#C2H2 ZF Containing Proteins#$#ENSP00000467069#ENSG00000161914#ENST00000592756#C2H2 ZF Containing Proteins#$#ENSP00000465955#ENSG00000161914#ENST00000589051#C2H2 ZF Containing Proteins#	FALSE
997	ENSG00000198839	ZNF277	C2H2 ZF; BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has a some znfC2H2 and znfBED domains	IPR007087;IPR015880	11179	zinc finger protein 277 [Source:HGNC Symbol;Acc:HGNC:13070]	None	Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000354501#ENSG00000198839#ENST00000361822#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4$#ENSP00000402292#ENSG00000198839#ENST00000450657#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-Di19$#ENSP00000410538#ENSG00000198839#ENST00000421043#C2H2 ZF Containing Proteins#zf-C2H2_2$#ENSP00000415735#ENSG00000198839#ENST00000421864#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-RVT$#ENSP00000390359#ENSG00000198839#ENST00000425229#C2H2 ZF Containing Proteins#zf-C2H2_2, zf-C2H2_4, zf-Di19	FALSE
998	ENSG00000243943	ZNF512	C2H2 ZF; BED ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Virtually nothing is known for this protein except that it has some of znfC2H2 domains and a znfBED domain and could thus be a TF	IPR003593;IPR004130;IPR027417;	84450	GPN-loop GTPase 1 [Source:HGNC Symbol;Acc:HGNC:17030]	None	DBD and Full	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000451572#ENSG00000243943#ENST00000556601#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000347648#ENSG00000243943#ENST00000355467#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000395660#ENSG00000243943#ENST00000413371#C2H2 ZF Containing Proteins#zf-C2H2_aberr$#ENSP00000407038#ENSG00000243943#ENST00000416005#C2H2 ZF Containing Proteins#zf-C2H2_aberr	FALSE
999	ENSG00000148516	ZEB1	C2H2 ZF; Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001356;IPR007087;IPR008598;IPR009057;IPR015880;	6935	zinc finger E-box binding homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11642]	None	DBD and Full	not tested	None	Jaspar ChIP-seq model has a robust and specific E-box like signal (as the name implies)	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:16129691	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000148516#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23814079$#ENSG00000148516#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8138542	$#ENSP00000319248#ENSG00000148516#ENST00000320985#C2H2 ZF Containing Proteins#$#ENSP00000354487#ENSG00000148516#ENST00000361642#C2H2 ZF Containing Proteins#$#ENSP00000453970#ENSG00000148516#ENST00000558440#C2H2 ZF Containing Proteins#$#ENSP00000444891#ENSG00000148516#ENST00000542815#C2H2 ZF Containing Proteins#$#ENSP00000453674#ENSG00000148516#ENST00000559476#C2H2 ZF Containing Proteins#$#ENSP00000452787#ENSG00000148516#ENST00000560721#C2H2 ZF Containing Proteins#	FALSE
1000	ENSG00000169554	ZEB2	C2H2 ZF; Homeodomain	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001356;IPR007087;IPR008598;IPR009057;IPR015880;	9839	zinc finger E-box binding homeobox 2 [Source:HGNC Symbol;Acc:HGNC:14881]	None	DBD and Full	not tested	None	ZEB1 Jaspar model makes sense, and binds E-box like sequence as the name implies	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11430829;12714599	Yes	2a2, orthologous lower confidence evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000169554#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:20516212	$#ENSP00000302501#ENSG00000169554#ENST00000303660#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000376601#ENSG00000169554#ENST00000392861#C2H2 ZF Containing Proteins#$#ENSP00000395496#ENSG00000169554#ENST00000427902#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000475329#ENSG00000169554#ENST00000470879#C2H2 ZF Containing Proteins#$#ENSP00000454157#ENSG00000169554#ENST00000558170#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000487174#ENSG00000169554#ENST00000627532#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000394777#ENSG00000169554#ENST00000419938#C2H2 ZF Containing Proteins#$#ENSP00000475502#ENSG00000169554#ENST00000465070#C2H2 ZF Containing Proteins#$#ENSP00000443792#ENSG00000169554#ENST00000539609#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000486240#ENSG00000169554#ENST00000629520#C2H2 ZF Containing Proteins#$#ENSP00000490776#ENSG00000169554#ENST00000636026#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490508#ENSG00000169554#ENST00000636413#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490317#ENSG00000169554#ENST00000636471#C2H2 ZF Containing Proteins#zf-C2H2_4$#ENSP00000490141#ENSG00000169554#ENST00000637045#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490293#ENSG00000169554#ENST00000637267#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490872#ENSG00000169554#ENST00000637304#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000489701#ENSG00000169554#ENST00000637873#C2H2 ZF Containing Proteins#$#ENSP00000490723#ENSG00000169554#ENST00000638007#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490673#ENSG00000169554#ENST00000638087#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-H2C2_2$#ENSP00000490934#ENSG00000169554#ENST00000638128#C2H2 ZF Containing Proteins#	FALSE
1001	ENSG00000140836	ZFHX3	C2H2 ZF; Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003604;IPR007087;IPR009057;IPR015880;IPR017970	463	zinc finger homeobox 3 [Source:HGNC Symbol;Acc:HGNC:777]	None	Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000140836#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1719379$#ENSG00000140836#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:1719379	$#ENSP00000268489#ENSG00000140836#ENST00000268489#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-H2C2_5, zf-met$#ENSP00000438926#ENSG00000140836#ENST00000397992#C2H2 ZF Containing Proteins#zf-C2H2_4, zf-Di19, zf-met	FALSE
1002	ENSG00000091656	ZFHX4	C2H2 ZF; Homeodomain	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	Curious protein with numerous C2H2 and homeodomain-like domains.	IPR001356;IPR003604;IPR007087;IPR009057;IPR015880;IPR017970	79776	Zinc finger homeobox 4	None	not tested	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Matt Weirauch	Tim Hughes	Yes	None	$#ENSP00000427775#ENSG00000091656#ENST00000517585#C2H2 ZF Containing Proteins#$#ENSP00000428525#ENSG00000091656#ENST00000520307#C2H2 ZF Containing Proteins#$#ENSP00000427739#ENSG00000091656#ENST00000523809#C2H2 ZF Containing Proteins#$#ENSP00000429495#ENSG00000091656#ENST00000523885#C2H2 ZF Containing Proteins#	FALSE
1003	ENSG00000124496	TRERF1	C2H2 ZF; Myb/SANT	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	Contains a SANT and multiple DNA-binding C2H2 domains.	IPR000949;IPR001005;IPR007087;IPR009057;IPR015880;IPR017884	55809	transcriptional regulating factor 1 [Source:HGNC Symbol;Acc:HGNC:18273]	None	DBD	not tested	None	None	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Pratyush Das	Yes	$#ENSG00000124496#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11349124	$#ENSP00000362008#ENSG00000124496#ENST00000372917#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000362013#ENSG00000124496#ENST00000372922#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000439689#ENSG00000124496#ENST00000541110#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1004	ENSG00000118156	ZNF541	C2H2 ZF; Myb/SANT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Has good looking ZF arrays and possible Myb domains.	IPR000949;IPR001005;IPR007087;IPR009057;IPR015880;IPR017884	84215	zinc finger protein 541 [Source:HGNC Symbol;Acc:HGNC:25294]	None	Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000118156#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000263351#ENSG00000118156#ENST00000263351#C2H2 ZF Containing Proteins#$#ENSP00000471665#ENSG00000118156#ENST00000595558#C2H2 ZF Containing Proteins#ELM2$#ENSP00000313258#ENSG00000118156#ENST00000314121#C2H2 ZF Containing Proteins#ELM2$#ENSP00000375770#ENSG00000118156#ENST00000391901#C2H2 ZF Containing Proteins#ELM2	FALSE
1005	ENSG00000001167	NFYA	CBF/NF-Y	Yes	Known motif	Obligate heteromer	In vivo/Misc source	None	Binds as a trimer with NFYB and NFYC.	IPR001289;IPR018362	4800	nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804]	4AWL	DBD	not tested	Obligate_Multimer	obligate heterotrimer of NFYA, NFYB and NFYC	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12070012;15601870	Yes	1a1, Direct HQ evidence	Mihai Albu	Jussi Taipale	Yes	$#ENSG00000001167#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000345702#ENSG00000001167#ENST00000341376#NFY#$#ENSP00000229418#ENSG00000001167#ENST00000353205#NFY#	FALSE
1006	ENSG00000160917	CPSF4	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001878	10898	cleavage and polyadenylation specific factor 4 [Source:HGNC Symbol;Acc:HGNC:2327]	None	not tested	not tested	None	None	x	No	No	No	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	No	None	$#ENSP00000292476#ENSG00000160917#ENST00000292476#CCCH ZF#zf-CCHC$#ENSP00000395311#ENSG00000160917#ENST00000436336#CCCH ZF#zf-CCHC$#ENSP00000402224#ENSG00000160917#ENST00000441580#CCCH ZF#zf-CCHC$#ENSP00000415188#ENSG00000160917#ENST00000440514#CCCH ZF#$#ENSP00000392584#ENSG00000160917#ENST00000452047#CCCH ZF#	FALSE
1007	ENSG00000187959	CPSF4L	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	642843	cleavage and polyadenylation specific factor 4-like [Source:HGNC Symbol;Acc:HGNC:33632]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000343900#ENSG00000187959#ENST00000344935#CCCH ZF#$#ENSP00000380788#ENSG00000187959#ENST00000397671#CCCH ZF#	FALSE
1008	ENSG00000163214	DHX57	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001650;IPR002464;IPR006575;IPR007502;IPR009060;IPR011545;IPR011709;IPR014001;IPR015940;IPR027417;	90957	DEAH-box helicase 57 [Source:HGNC Symbol;Acc:HGNC:20086]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000405111#ENSG00000163214#ENST00000457308#CCCH ZF#AAA_14, AAA_19, AAA_22, DEAD, HA2, Helicase_C, NB-$#ENSP00000387404#ENSG00000163214#ENST00000442331#CCCH ZF#$#ENSP00000479840#ENSG00000163214#ENST00000619207#CCCH ZF#$#ENSP00000397841#ENSG00000163214#ENST00000452978#CCCH ZF#HA2, Helicase_C, OB_NTP_bind	FALSE
1009	ENSG00000141994	DUS3L	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001269;IPR018517;	56931	dihydrouridine synthase 3 like [Source:HGNC Symbol;Acc:HGNC:26920]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000311977#ENSG00000141994#ENST00000309061#CCCH ZF#Dus$#ENSP00000315558#ENSG00000141994#ENST00000320699#CCCH ZF#Dus$#ENSP00000466351#ENSG00000141994#ENST00000590343#CCCH ZF#$#ENSP00000467302#ENSG00000141994#ENST00000592491#CCCH ZF#	FALSE
1010	ENSG00000198265	HELZ	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR027417	9931	helicase with zinc finger [Source:HGNC Symbol;Acc:HGNC:16878]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000351524#ENSG00000198265#ENST00000358691#CCCH ZF#AAA_11, AAA_12, AAA_19, AAA_30, PAM2, PhoH, ResIII$#ENSP00000464512#ENSG00000198265#ENST00000580168#CCCH ZF#AAA_11, AAA_12, AAA_19, AAA_30, PAM2, PhoH, ResIII$#ENSP00000464354#ENSG00000198265#ENST00000578783#CCCH ZF#TetR_C_8$#ENSP00000462320#ENSG00000198265#ENST00000579861#CCCH ZF#TPR_1$#ENSP00000462763#ENSG00000198265#ENST00000581159#CCCH ZF#TPR_1, TPR_2	FALSE
1011	ENSG00000152601	MBNL1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	4154	muscleblind like splicing regulator 1 [Source:HGNC Symbol;Acc:HGNC:6923]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000319429#ENSG00000152601#ENST00000324210#CCCH ZF#$#ENSP00000347637#ENSG00000152601#ENST00000355460#CCCH ZF#$#ENSP00000418108#ENSG00000152601#ENST00000463374#CCCH ZF#$#ENSP00000417630#ENSG00000152601#ENST00000465907#CCCH ZF#$#ENSP00000418508#ENSG00000152601#ENST00000478535#CCCH ZF#$#ENSP00000418876#ENSG00000152601#ENST00000485509#CCCH ZF#$#ENSP00000418427#ENSG00000152601#ENST00000485910#CCCH ZF#$#ENSP00000420103#ENSG00000152601#ENST00000492948#CCCH ZF#$#ENSP00000419347#ENSG00000152601#ENST00000493459#CCCH ZF#$#ENSP00000417741#ENSG00000152601#ENST00000495875#CCCH ZF#$#ENSP00000420680#ENSG00000152601#ENST00000460591#CCCH ZF#	FALSE
1012	ENSG00000139793	MBNL2	CCCH ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	High-throughput in vitro	None	Has methylated and unmethylated HT-SELEX motifs, despite this family largely binding RNA exclusively (PMID: 28473536 )	IPR000571;	10150	muscleblind like splicing regulator 2 [Source:HGNC Symbol;Acc:HGNC:16746]	None	Full	not tested	None	None	x	No	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000344214#ENSG00000139793#ENST00000343600#CCCH ZF#$#ENSP00000267287#ENSG00000139793#ENST00000345429#CCCH ZF#$#ENSP00000365861#ENSG00000139793#ENST00000376673#CCCH ZF#$#ENSP00000404202#ENSG00000139793#ENST00000449284#CCCH ZF#	FALSE
1013	ENSG00000076770	MBNL3	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	55796	muscleblind like splicing regulator 3 [Source:HGNC Symbol;Acc:HGNC:20564]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000359876#ENSG00000076770#ENST00000370839#CCCH ZF#$#ENSP00000359881#ENSG00000076770#ENST00000370844#CCCH ZF#$#ENSP00000359890#ENSG00000076770#ENST00000370853#CCCH ZF#$#ENSP00000439618#ENSG00000076770#ENST00000538204#CCCH ZF#$#ENSP00000359886#ENSG00000076770#ENST00000370849#CCCH ZF#$#ENSP00000377848#ENSG00000076770#ENST00000394311#CCCH ZF#$#ENSP00000412065#ENSG00000076770#ENST00000442191#CCCH ZF#$#ENSP00000406014#ENSG00000076770#ENST00000436215#CCCH ZF#	FALSE
1014	ENSG00000133606	MKRN1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001841;IPR017907;IPR018957	23608	makorin ring finger protein 1 [Source:HGNC Symbol;Acc:HGNC:7112]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000255977#ENSG00000133606#ENST00000255977#CCCH ZF#MKRN1_C, zf-ANAPC11, zf-C3HC4, zf-C3HC4_4, zf-RING$#ENSP00000416369#ENSG00000133606#ENST00000443720#CCCH ZF#zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-R$#ENSP00000418620#ENSG00000133606#ENST00000473444#CCCH ZF#$#ENSP00000419843#ENSG00000133606#ENST00000494939#CCCH ZF#	FALSE
1015	ENSG00000075975	MKRN2	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001841;IPR017907;IPR018957	23609	makorin ring finger protein 2 [Source:HGNC Symbol;Acc:HGNC:7113]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$#ENSP00000170447#ENSG00000075975#ENST00000170447#CCCH ZF#zf-C3HC4, zf-C3HC4_4, zf-RING_11, zf-RING_2, zf-RI$#ENSP00000396340#ENSG00000075975#ENST00000411987#CCCH ZF#zf-C3HC4, zf-C3HC4_4, zf-RING_2, zf-RING_5, zf-RIN$#ENSP00000397983#ENSG00000075975#ENST00000448482#CCCH ZF#zf-C3HC4, zf-C3HC4_4, zf-RING_11, zf-RING_2, zf-RI	FALSE
1016	ENSG00000136243	NUPL2	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	11097	nucleoporin like 2 [Source:HGNC Symbol;Acc:HGNC:17010]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000258742#ENSG00000136243#ENST00000258742#CCCH ZF#$#ENSP00000387330#ENSG00000136243#ENST00000410002#CCCH ZF#$#ENSP00000401475#ENSG00000136243#ENST00000413919#CCCH ZF#$#ENSP00000482736#ENSG00000136243#ENST00000548367#CCCH ZF#	FALSE
1017	ENSG00000059378	PARP12	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely an RNA binding protein (PMID: 25086041).	IPR000571;IPR004170;IPR012317;	64761	poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol;Acc:HGNC:21919]	None	Full	not tested	None	None	x	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0;15273990;;	No	4a, two or more datasets predict it as a TF	Pratyush Das	Matt Weirauch	No	None	$#ENSP00000263549#ENSG00000059378#ENST00000263549#CCCH ZF#PARP, Torus, WWE$#ENSP00000417606#ENSG00000059378#ENST00000489809#CCCH ZF#$#ENSP00000418640#ENSG00000059378#ENST00000484111#CCCH ZF#PARP	FALSE
1018	ENSG00000204569	PPP1R10	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Close ortholog (PP1RA) binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (Uniprot).	IPR000571;IPR003617;IPR017923;	5514	protein phosphatase 1 regulatory subunit 10 [Source:HGNC Symbol;Acc:HGNC:9284]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000365694#ENSG00000204569#ENST00000376511#CCCH ZF#Med26	FALSE
1019	ENSG00000204576	PRR3	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	80742	proline rich 3 [Source:HGNC Symbol;Acc:HGNC:21149]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000365744#ENSG00000204576#ENST00000376560#CCCH ZF#$#ENSP00000365740#ENSG00000204576#ENST00000376557#CCCH ZF#	FALSE
1020	ENSG00000135870	RC3H1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	A well established RNA-binding protein reviewed in (PMID: 26489670).	IPR000571;IPR001841;IPR017907;	149041	ring finger and CCCH-type domains 1 [Source:HGNC Symbol;Acc:HGNC:29434]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000258349#ENSG00000135870#ENST00000258349#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_$#ENSP00000356667#ENSG00000135870#ENST00000367694#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_$#ENSP00000356669#ENSG00000135870#ENST00000367696#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_	FALSE
1021	ENSG00000056586	RC3H2	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001841;IPR017907;	54542	ring finger and CCCH-type domains 2 [Source:HGNC Symbol;Acc:HGNC:21461]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	Yes	None	$#ENSP00000335150#ENSG00000056586#ENST00000335387#CCCH ZF#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-$#ENSP00000474148#ENSG00000056586#ENST00000471874#CCCH ZF#FYVE, Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_	FALSE
1022	ENSG00000125352	RNF113A	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001841;IPR017907;	7737	ring finger protein 113A [Source:HGNC Symbol;Acc:HGNC:12974]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Yimeng Yin	No	None	$#ENSP00000360497#ENSG00000125352#ENST00000371442#CCCH ZF#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-N	FALSE
1023	ENSG00000139797	RNF113B	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001841;IPR017907;	140432	ring finger protein 113B [Source:HGNC Symbol;Acc:HGNC:17267]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000267291#ENSG00000139797#ENST00000267291#CCCH ZF#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-N	FALSE
1024	ENSG00000132773	TOE1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR006941;IPR012337;	114034	target of EGR1, member 1 (nuclear) [Source:HGNC Symbol;Acc:HGNC:15954]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000361162#ENSG00000132773#ENST00000372090#CCCH ZF#CAF1	FALSE
1025	ENSG00000104907	TRMT1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR002905;IPR029063;	55621	tRNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:25980]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	No	None	$#ENSP00000221504#ENSG00000104907#ENST00000221504#CCCH ZF#Cons_hypoth95, Met_10, TRM$#ENSP00000416149#ENSG00000104907#ENST00000437766#CCCH ZF#Cons_hypoth95, Met_10, TRM$#ENSP00000350352#ENSG00000104907#ENST00000357720#CCCH ZF#Cons_hypoth95, Met_10, TRM$#ENSP00000467984#ENSG00000104907#ENST00000588229#CCCH ZF#TRM$#ENSP00000465370#ENSG00000104907#ENST00000587487#CCCH ZF#TRM$#ENSP00000467938#ENSG00000104907#ENST00000592814#CCCH ZF#Cons_hypoth95, Met_10, TRM	FALSE
1026	ENSG00000132478	UNK	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	85451	unkempt family zinc finger [Source:HGNC Symbol;Acc:HGNC:29369]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000464893#ENSG00000132478#ENST00000589666#CCCH ZF#Alanine_zipper, DUF3450, DUF4407, Fez1, THOC7, zf-$#ENSP00000467726#ENSG00000132478#ENST00000587258#CCCH ZF#APG6, Alanine_zipper, CENP-Q, DUF3450, DUF4407, Fe	FALSE
1027	ENSG00000059145	UNKL	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR001841	64718	Unkempt family like zinc finger [Source:HGNC Symbol;Acc:HGNC:14184]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000248104#ENSG00000059145#ENST00000248104#CCCH ZF#DUF3450, Filament, Mnd1, Prok-RING_4, zf-C3HC4_3, $#ENSP00000301712#ENSG00000059145#ENST00000301712#CCCH ZF#$#ENSP00000380606#ENSG00000059145#ENST00000397464#CCCH ZF#Filament, Prok-RING_4, zf-C3HC4_3, zf-RING_5$#ENSP00000384850#ENSG00000059145#ENST00000402641#CCCH ZF#Filament, Halogen_Hydrol	FALSE
1028	ENSG00000135482	ZC3H10	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	84872	zinc finger CCCH-type containing 10 [Source:HGNC Symbol;Acc:HGNC:25893]	None	not tested	Yes	None	RBP	x	Yes	No	No	4a, two or more datasets predict it as a TF	Tim Hughes	Matt Weirauch	No	None	$#ENSP00000257940#ENSG00000135482#ENST00000257940#CCCH ZF#$#ENSP00000448881#ENSG00000135482#ENST00000546903#CCCH ZF#$#ENSP00000448309#ENSG00000135482#ENST00000551880#CCCH ZF#$#ENSP00000450122#ENSG00000135482#ENST00000552345#CCCH ZF#	FALSE
1029	ENSG00000058673	ZC3H11A	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	9877	zinc finger CCCH-type containing 11A [Source:HGNC Symbol;Acc:HGNC:29093]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000333253#ENSG00000058673#ENST00000332127#Other#zf-CCCH_3$#ENSP00000356179#ENSG00000058673#ENST00000367210#Other#zf-CCCH_3$#ENSP00000356181#ENSG00000058673#ENST00000367212#Other#zf-CCCH_3$#ENSP00000438527#ENSG00000058673#ENST00000545588#Other#zf-CCCH_3$#ENSP00000356183#ENSG00000058673#ENST00000367214#Other#zf-CCCH_3	FALSE
1030	ENSG00000163874	ZC3H12A	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR021869	102465438	zinc finger CCCH-type containing 12A [Source:HGNC Symbol;Acc:HGNC:26259];Endoribonuclease ZC3H12A	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000163874#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18178554	$#ENSP00000362179#ENSG00000163874#ENST00000373087#Other#RNase_Zc3h12a$#ENSP00000473447#ENSG00000163874#ENST00000471012#Other#RNase_Zc3h12a	FALSE
1031	ENSG00000123200	ZC3H13	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	23091	zinc finger CCCH-type containing 13 [Source:HGNC Symbol;Acc:HGNC:20368]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000282007#ENSG00000123200#ENST00000282007#CCCH ZF#$#ENSP00000480658#ENSG00000123200#ENST00000464597#CCCH ZF#DUF3736$#ENSP00000416238#ENSG00000123200#ENST00000428921#CCCH ZF#$#ENSP00000242848#ENSG00000123200#ENST00000242848#CCCH ZF#	FALSE
1032	ENSG00000100722	ZC3H14	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds UUUNUUU RNA-sequence based on Ray et al 2013 (PMID: 23846655).	IPR000571;	79882	zinc finger CCCH-type containing 14 [Source:HGNC Symbol;Acc:HGNC:20509]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000251038#ENSG00000100722#ENST00000251038#Other#zf-CCCH_2$#ENSP00000307025#ENSG00000100722#ENST00000302216#Other#zf-CCCH_2$#ENSP00000327176#ENSG00000100722#ENST00000318308#Other#zf-CCCH_2$#ENSP00000338002#ENSG00000100722#ENST00000336693#Other#zf-CCCH_2$#ENSP00000451054#ENSG00000100722#ENST00000556000#Other#zf-CCCH_2$#ENSP00000452475#ENSG00000100722#ENST00000555755#Other#zf-CCCH_2$#ENSP00000384682#ENSG00000100722#ENST00000406216#Other#zf-CCCH_2$#ENSP00000450823#ENSG00000100722#ENST00000555792#Other#zf-CCCH_2, zf-TAZ$#ENSP00000451489#ENSG00000100722#ENST00000555799#Other#$#ENSP00000451389#ENSG00000100722#ENST00000556158#Other#$#ENSP00000477763#ENSG00000100722#ENST00000557047#Other#$#ENSP00000452210#ENSG00000100722#ENST00000557693#Other#	FALSE
1033	ENSG00000065548	ZC3H15	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	55854	zinc finger CCCH-type containing 15 [Source:HGNC Symbol;Acc:HGNC:29528]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000338788#ENSG00000065548#ENST00000337859#CCCH ZF#DFRP_C, Torus$#ENSP00000415788#ENSG00000065548#ENST00000445547#CCCH ZF#	FALSE
1034	ENSG00000158545	ZC3H18	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	124245	zinc finger CCCH-type containing 18 [Source:HGNC Symbol;Acc:HGNC:25091]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$#ENSP00000301011#ENSG00000158545#ENST00000301011#CCCH ZF#$#ENSP00000416951#ENSG00000158545#ENST00000452588#CCCH ZF#$#ENSP00000456241#ENSG00000158545#ENST00000565583#CCCH ZF#	FALSE
1035	ENSG00000014164	ZC3H3	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	23144	zinc finger CCCH-type containing 3 [Source:HGNC Symbol;Acc:HGNC:28972]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Tim Hughes	No	None	$#ENSP00000262577#ENSG00000014164#ENST00000262577#CCCH ZF#$#ENSP00000436834#ENSG00000014164#ENST00000528401#CCCH ZF#	FALSE
1036	ENSG00000130749	ZC3H4	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR000571;	23211	zinc finger CCCH-type containing 4 [Source:HGNC Symbol;Acc:HGNC:17808]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	Yes	None	$#ENSP00000253048#ENSG00000130749#ENST00000253048#CCCH ZF#$#ENSP00000469684#ENSG00000130749#ENST00000601973#CCCH ZF#	FALSE
1037	ENSG00000188177	ZC3H6	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;	376940	zinc finger CCCH-type containing 6 [Source:HGNC Symbol;Acc:HGNC:24762]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000386764#ENSG00000188177#ENST00000409871#CCCH ZF#$#ENSP00000340298#ENSG00000188177#ENST00000343936#CCCH ZF#	FALSE
1038	ENSG00000122299	ZC3H7A	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR022755	29066	zinc finger CCCH-type containing 7A [Source:HGNC Symbol;Acc:HGNC:30959]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000347999#ENSG00000122299#ENST00000355758#CCCH ZF#TPR_2, zf-C2H2_jaz$#ENSP00000379773#ENSG00000122299#ENST00000396516#CCCH ZF#TPR_2, zf-C2H2_jaz$#ENSP00000459477#ENSG00000122299#ENST00000575984#CCCH ZF#zf-C2H2_jaz, zf-met$#ENSP00000459747#ENSG00000122299#ENST00000571198#CCCH ZF#TPR_2$#ENSP00000460122#ENSG00000122299#ENST00000576009#CCCH ZF#	FALSE
1039	ENSG00000100403	ZC3H7B	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR013026;IPR019734;	23264	Zinc finger CCCH-type containing 7B [Source:HGNC Symbol;Acc:HGNC:30869]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000345793#ENSG00000100403#ENST00000352645#CCCH ZF#ANAPC3, TPR_1, TPR_12, TPR_2, TPR_8, zf-C2H2_2	FALSE
1040	ENSG00000144161	ZC3H8	CCCH ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Mouse ortholog can bind DNA specifically, based on EMSA (PMID: 12077251).	IPR000571;	84524	zinc finger CCCH-type containing 8 [Source:HGNC Symbol;Acc:HGNC:30941]	None	not tested	not tested	None	RBP	x	No	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:12077251	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000144161#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000144161#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:12153508	$#ENSP00000272570#ENSG00000144161#ENST00000272570#CCCH ZF#$#ENSP00000386488#ENSG00000144161#ENST00000409573#CCCH ZF#$#ENSP00000483976#ENSG00000144161#ENST00000615791#CCCH ZF#	FALSE
1041	ENSG00000105939	ZC3HAV1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein (PMID: 22658674; PMID: 22681889).	IPR000571;IPR004170;IPR012317;	56829	zinc finger CCCH-type containing, antiviral 1 [Source:HGNC Symbol;Acc:HGNC:23721]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000242351#ENSG00000105939#ENST00000242351#Other#PARP, WWE$#ENSP00000420107#ENSG00000105939#ENST00000460845#Other#WWE$#ENSP00000419855#ENSG00000105939#ENST00000471652#Other#WWE$#ENSP00000418385#ENSG00000105939#ENST00000464606#Other#PARP, WWE	FALSE
1042	ENSG00000128016	ZFP36	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA binding protein (PMID: 10330172).	IPR000571;	7538	ZFP36 ring finger protein [Source:HGNC Symbol;Acc:HGNC:12862]	None	not tested	not tested	None	None	x	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000469647#ENSG00000128016#ENST00000597629#CCCH ZF#$#ENSP00000472329#ENSG00000128016#ENST00000594045#CCCH ZF#$#ENSP00000470200#ENSG00000128016#ENST00000600033#CCCH ZF#$#ENSP00000471239#ENSG00000128016#ENST00000594442#CCCH ZF#	FALSE
1043	ENSG00000185650	ZFP36L1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein (PMID: 27102483; PMID: 17013884).	IPR000571;IPR007635	677	ZFP36 ring finger protein-like 1 [Source:HGNC Symbol;Acc:HGNC:1107]	None	DBD and Full	not tested	None	None	b	No	Probably Not a TF - No evidence that it is a TF___PMIDS:0	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000185650#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8595910	$#ENSP00000388402#ENSG00000185650#ENST00000439696#CCCH ZF#Tis11B_N$#ENSP00000337386#ENSG00000185650#ENST00000336440#CCCH ZF#Tis11B_N$#ENSP00000452119#ENSG00000185650#ENST00000553375#CCCH ZF#Tis11B_N$#ENSP00000450784#ENSG00000185650#ENST00000557086#CCCH ZF#Tis11B_N$#ENSP00000451093#ENSG00000185650#ENST00000555997#CCCH ZF#	FALSE
1044	ENSG00000152518	ZFP36L2	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein (PMID: 20506496).	IPR000571;IPR007635	678	ZFP36 ring finger protein-like 2 [Source:HGNC Symbol;Acc:HGNC:1108]	None	DBD	not tested	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000152518#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7835719	$#ENSP00000282388#ENSG00000152518#ENST00000282388#CCCH ZF#Tis11B_N	FALSE
1045	ENSG00000197114	ZGPAT	CCCH ZF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds RRRGGAGGAGA based on SELEX and EMSA (PMID: 19644445).	IPR000467;IPR000571	84619	zinc finger CCCH-type and G-patch domain containing [Source:HGNC Symbol;Acc:HGNC:15948]	None	not tested	not tested	None	None	x	No	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000197114#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19644445$#ENSG00000197114#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19644445	$#ENSP00000348242#ENSG00000197114#ENST00000355969#CCCH ZF#G-patch, Laminin_I$#ENSP00000349634#ENSG00000197114#ENST00000357119#CCCH ZF#G-patch, Laminin_I$#ENSP00000391176#ENSG00000197114#ENST00000448100#CCCH ZF#G-patch, Laminin_I$#ENSP00000332013#ENSG00000197114#ENST00000328969#CCCH ZF#G-patch, Laminin_I$#ENSP00000403966#ENSG00000197114#ENST00000431125#CCCH ZF#	FALSE
1046	ENSG00000100319	ZMAT5	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000571;IPR013085	55954	zinc finger matrin-type 5 [Source:HGNC Symbol;Acc:HGNC:28046]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000344241#ENSG00000100319#ENST00000344318#CCCH ZF#zf-U1	FALSE
1047	ENSG00000212643	ZRSR1	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504;IPR000571;IPR003954;IPR009145	None	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 [Source:HGNC Symbol;Acc:HGNC:124	None	Full	not tested	None	None	x	No	Not a TF - Evidence that it is not a TF__Other_PMIDS:14673161	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000375133#ENSG00000212643#ENST00000391338#Other#	FALSE
1048	ENSG00000169249	ZRSR2	CCCH ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504;IPR000571;IPR003954;IPR009145	8233	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 [Source:HGNC Symbol;Acc:HGNC:230	None	Full	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000303015#ENSG00000169249#ENST00000307771#Other#$#ENSP00000369664#ENSG00000169249#ENST00000380308#Other#	FALSE
1049	ENSG00000125817	CENPB	CENPB	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004875;IPR006600;IPR007889;IPR009057;IPR015115;	1059	centromere protein B [Source:HGNC Symbol;Acc:HGNC:1852]	1HLV	Full	not tested	None	Structure has many contacts between the AA-residues and the DNA-bases in the major groove, could well be sequence-specific	x	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000369075#ENSG00000125817#ENST00000379751#CENP-B N-terminal DNA-binding domain#CENP-B_dimeris, DDE_1, HTH_Tnp_Tc5	FALSE
1050	ENSG00000177946	CENPBD1	CENPB	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR006600;IPR007889;IPR009057;	92806	CENPB DNA-binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28272]	None	not tested	Yes	None	None	No	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000393854#ENSG00000177946#ENST00000314994#CENP-B N-terminal DNA-binding domain#HTH_Tnp_Tc5	FALSE
1051	ENSG00000234616	JRK	CENPB	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR004875;IPR006600;IPR007889;IPR009057	8629	Jrk helix-turn-helix protein [Source:HGNC Symbol;Acc:HGNC:6199]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	None	$#ENSP00000461610#ENSG00000234616#ENST00000571961#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000485390#ENSG00000234616#ENST00000614134#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000483808#ENSG00000234616#ENST00000615982#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000482410#ENSG00000234616#ENST00000612905#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1052	ENSG00000183340	JRKL	CENPB	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004875;IPR006600;IPR007889;IPR009057	8690	JRK-like [Source:HGNC Symbol;Acc:HGNC:6200]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000333350#ENSG00000183340#ENST00000332349#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1053	ENSG00000221944	TIGD1	CENPB	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004875;IPR006600;IPR007889;IPR009057	100847037	tigger transposable element derived 1 [Source:HGNC Symbol;Acc:HGNC:14523]	None	not tested	Yes	None	None	No	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	No	None	$#ENSP00000386186#ENSG00000221944#ENST00000408957#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1054	ENSG00000180346	TIGD2	CENPB	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004875;IPR006600;IPR007889;IPR009057	166815	tigger transposable element derived 2 [Source:HGNC Symbol;Acc:HGNC:18333]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000486687#ENSG00000180346#ENST00000603357#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000317170#ENSG00000180346#ENST00000317005#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1055	ENSG00000173825	TIGD3	CENPB	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR004875;IPR006600;IPR007889;IPR009057	220359	tigger transposable element derived 3 [Source:HGNC Symbol;Acc:HGNC:18334]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000308354#ENSG00000173825#ENST00000309880#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1056	ENSG00000169989	TIGD4	CENPB	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Evidence showing that the two HTH domains in the protein together bind specifically to a 17-base-pair sequence; the CENP-B box; which occurs in alpha-satellite DNA in human centromeres (PMID: 16183641).	IPR004875;IPR006600;IPR007889;IPR009057	201798	tigger transposable element derived 4 [Source:HGNC Symbol;Acc:HGNC:18335]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000355162#ENSG00000169989#ENST00000304337#CENP-B N-terminal DNA-binding domain#CENP-B_dimeris, DDE_1, HTH_Tnp_Tc5	FALSE
1057	ENSG00000179886	TIGD5	CENPB	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR004875;IPR006600;IPR007889;IPR009057	84948	tigger transposable element derived 5 [Source:HGNC Symbol;Acc:HGNC:18336]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000421489#ENSG00000179886#ENST00000504548#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1058	ENSG00000164296	TIGD6	CENPB	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR004875;IPR006600;IPR007889;IPR009057	81789	tigger transposable element derived 6 [Source:HGNC Symbol;Acc:HGNC:18332]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000296736#ENSG00000164296#ENST00000296736#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000425318#ENSG00000164296#ENST00000515406#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5	FALSE
1059	ENSG00000140993	TIGD7	CENPB	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR004875;IPR006600;IPR007889;IPR009057	91151	tigger transposable element derived 7 [Source:HGNC Symbol;Acc:HGNC:18331]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000380071#ENSG00000140993#ENST00000396862#CENP-B N-terminal DNA-binding domain#DDE_1, HTH_Tnp_Tc5$#ENSP00000459534#ENSG00000140993#ENST00000573608#CENP-B N-terminal DNA-binding domain#HTH_Tnp_Tc5	FALSE
1060	ENSG00000171735	CAMTA1	CG-1	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds CGCATTGCG based on EMSA performed in (PMID: 25049392)	IPR000048;IPR002110;IPR002909;IPR005559;IPR014756;IPR020683;IPR027417;	23261	calmodulin binding transcription activator 1 [Source:HGNC Symbol;Acc:HGNC:18806]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000171735#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000306522#ENSG00000171735#ENST00000303635#CG-1#Ank_2, Ank_3, Ank_4, Ank_5, IQ, TIG$#ENSP00000451388#ENSG00000171735#ENST00000473578#CG-1#$#ENSP00000452319#ENSG00000171735#ENST00000476864#CG-1#IQ$#ENSP00000452024#ENSG00000171735#ENST00000490905#CG-1#IQ$#ENSP00000451720#ENSG00000171735#ENST00000495233#CG-1#Ank, Ank_2, Ank_3, Ank_4, Ank_5, IQ$#ENSP00000451510#ENSG00000171735#ENST00000557126#CG-1#$#ENSP00000450530#ENSG00000171735#ENST00000467404#CG-1#	FALSE
1061	ENSG00000108509	CAMTA2	CG-1	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000048;IPR002909;IPR005559;IPR014756;IPR020683;IPR027417	23125	calmodulin binding transcription activator 2 [Source:HGNC Symbol;Acc:HGNC:18807]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:16678093	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000108509#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000321813#ENSG00000108509#ENST00000348066#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG$#ENSP00000354828#ENSG00000108509#ENST00000361571#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG$#ENSP00000370712#ENSG00000108509#ENST00000381311#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG$#ENSP00000412886#ENSG00000108509#ENST00000414043#CG-1#Ank_2, Ank_3, Ank_5, IQ, TIG	FALSE
1062	ENSG00000153048	CARHSP1	CSD	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein (PMID: 11842224; PMID: 21078874)	IPR002059;IPR011129;IPR012340;IPR019844	23589	calcium regulated heat stable protein 1 [Source:HGNC Symbol;Acc:HGNC:17150]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000311847#ENSG00000153048#ENST00000311052#Cold-shock protein, DNA-binding#$#ENSP00000379838#ENSG00000153048#ENST00000396593#Cold-shock protein, DNA-binding#$#ENSP00000460812#ENSG00000153048#ENST00000562843#Cold-shock protein, DNA-binding#$#ENSP00000455855#ENSG00000153048#ENST00000567554#Cold-shock protein, DNA-binding#$#ENSP00000455522#ENSG00000153048#ENST00000567908#Cold-shock protein, DNA-binding#$#ENSP00000455988#ENSG00000153048#ENST00000568968#Cold-shock protein, DNA-binding#DUF4339$#ENSP00000457213#ENSG00000153048#ENST00000569398#Cold-shock protein, DNA-binding#$#ENSP00000478055#ENSG00000153048#ENST00000610831#Cold-shock protein, DNA-binding#$#ENSP00000455284#ENSG00000153048#ENST00000561530#Cold-shock protein, DNA-binding#$#ENSP00000455016#ENSG00000153048#ENST00000565287#Cold-shock protein, DNA-binding#$#ENSP00000456909#ENSG00000153048#ENST00000568117#Cold-shock protein, DNA-binding#$#ENSP00000481550#ENSG00000153048#ENST00000611932#Cold-shock protein, DNA-binding#$#ENSP00000480144#ENSG00000153048#ENST00000619881#Cold-shock protein, DNA-binding#	FALSE
1063	ENSG00000172346	CSDC2	CSD	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein (PMID: 12801884)	IPR002059;IPR011129;IPR012340;IPR019844	27254	cold shock domain containing C2 [Source:HGNC Symbol;Acc:HGNC:30359]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000302485#ENSG00000172346#ENST00000306149#Cold-shock protein, DNA-binding#$#ENSP00000417127#ENSG00000172346#ENST00000460790#Cold-shock protein, DNA-binding#	FALSE
1064	ENSG00000009307	CSDE1	CSD	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Established RNA-binding protein.	IPR002059;IPR011129;IPR012340;IPR019844;IPR024642;	7812	cold shock domain containing E1 [Source:HGNC Symbol;Acc:HGNC:29905]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Tim Hughes	Yimeng Yin	No	None	$#ENSP00000261443#ENSG00000009307#ENST00000261443#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000342408#ENSG00000009307#ENST00000339438#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000351329#ENSG00000009307#ENST00000358528#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000358543#ENSG00000009307#ENST00000369530#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000407724#ENSG00000009307#ENST00000438362#Cold-shock protein, DNA-binding#SUZ-C$#ENSP00000432958#ENSG00000009307#ENST00000534699#Cold-shock protein, DNA-binding#SUZ-C	FALSE
1065	ENSG00000131914	LIN28A	CSD	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Might also bind RNA	IPR001878;IPR002059;IPR011129;IPR012340	79727	lin-28 homolog A [Source:HGNC Symbol;Acc:HGNC:15986]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Matt Weirauch	No	None	$#ENSP00000254231#ENSG00000131914#ENST00000254231#Cold-shock protein, DNA-binding#zf-CCHC$#ENSP00000363314#ENSG00000131914#ENST00000326279#Cold-shock protein, DNA-binding#zf-CCHC	FALSE
1066	ENSG00000187772	LIN28B	CSD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Structure (PDB: 4A75) is with single stranded DNA.	IPR001878;IPR002059;IPR011129;IPR012340	389421	lin-28 homolog B [Source:HGNC Symbol;Acc:HGNC:32207]	4A75	Full	not tested	None	Structure is with single stranded DNA	x	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000344401#ENSG00000187772#ENST00000345080#Cold-shock protein, DNA-binding#zf-CCHC$#ENSP00000489735#ENSG00000187772#ENST00000635857#Cold-shock protein, DNA-binding#zf-CCHC$#ENSP00000490468#ENSG00000187772#ENST00000637759#Cold-shock protein, DNA-binding#zf-CCHC	FALSE
1067	ENSG00000065978	YBX1	CSD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Might also bind RNA	IPR002059;IPR011129;IPR012340;IPR019844	4904	Y-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8014]	None	DBD	not tested	None	None	a	Yes	TF Gene_Single stranded RNA/DNA binding_TF PPI_PMIDS:15039105;15702969;1741293;15039105	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000065978#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18809583$#ENSG00000065978#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:3174636	$#ENSP00000361626#ENSG00000065978#ENST00000321358#Cold-shock protein, DNA-binding#$#ENSP00000389639#ENSG00000065978#ENST00000436427#Cold-shock protein, DNA-binding#$#ENSP00000405937#ENSG00000065978#ENST00000332220#Cold-shock protein, DNA-binding#	FALSE
1068	ENSG00000006047	YBX2	CSD	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Might also bind RNA	IPR002059;IPR011129;IPR012340;IPR019844	51087	Y-box binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17948]	None	Full	Yes	None	None	x	Yes	No	No	1a2, Orthologous HQ evidence	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000007699#ENSG00000006047#ENST00000007699#Cold-shock protein, DNA-binding#$#ENSP00000459587#ENSG00000006047#ENST00000571464#Cold-shock protein, DNA-binding#	FALSE
1069	ENSG00000060138	YBX3	CSD	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	Identical DBD to YBX1. Might also bind RNA.	IPR002059;IPR011129;IPR012340;IPR019844	8531	Y-box binding protein 3 [Source:HGNC Symbol;Acc:HGNC:2428]	None	DBD	not tested	None	None	a	Yes	Not a TF - Evidence that it is not a TF___PMIDS:0	Yes	1a2, Orthologous HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000060138#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000060138#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8710501	$#ENSP00000228251#ENSG00000060138#ENST00000228251#Cold-shock protein, DNA-binding#$#ENSP00000279550#ENSG00000060138#ENST00000279550#Cold-shock protein, DNA-binding#Herpes_LMP1$#ENSP00000485718#ENSG00000060138#ENST00000544622#Cold-shock protein, DNA-binding#	FALSE
1070	ENSG00000168214	RBPJ	CSL	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002909;IPR008967;IPR014756;IPR015350;IPR015351;	3516	recombination signal binding protein for immunoglobulin kappa J region [Source:HGNC Symbol;Acc:HGNC:	2F8X	DBD and Full	Yes	None	RBPJ contacts DNA in the structure 2F8X, structure has also MAML1, but that does not contact the DNA	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8152928;8625826	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000168214#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18663143$#ENSG00000168214#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9874765	$#ENSP00000340124#ENSG00000168214#ENST00000342320#LAG1, DNA binding#BTD, TIG$#ENSP00000305815#ENSG00000168214#ENST00000345843#LAG1, DNA binding#BTD, TIG$#ENSP00000339699#ENSG00000168214#ENST00000348160#LAG1, DNA binding#BTD, TIG$#ENSP00000347659#ENSG00000168214#ENST00000355476#LAG1, DNA binding#BTD, TIG$#ENSP00000354528#ENSG00000168214#ENST00000361572#LAG1, DNA binding#BTD, TIG$#ENSP00000423907#ENSG00000168214#ENST00000507561#LAG1, DNA binding#BTD, TIG$#ENSP00000424804#ENSG00000168214#ENST00000509158#LAG1, DNA binding#$#ENSP00000423644#ENSG00000168214#ENST00000512671#LAG1, DNA binding#$#ENSP00000424459#ENSG00000168214#ENST00000504938#LAG1, DNA binding#$#ENSP00000424989#ENSG00000168214#ENST00000514807#LAG1, DNA binding#	FALSE
1071	ENSG00000124232	RBPJL	CSL	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR008967;IPR014756;IPR015350;IPR015351	11317	recombination signal binding protein for immunoglobulin kappa J region like [Source:HGNC Symbol;Acc:	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9111338;9111338;9111338;9111338;16354684	Yes	3a, decent circumstantial evidence for its role as	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000124232#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000002$#ENSG00000124232#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9929984	$#ENSP00000361826#ENSG00000124232#ENST00000372741#LAG1, DNA binding#BTD$#ENSP00000361828#ENSG00000124232#ENST00000372743#LAG1, DNA binding#BTD$#ENSP00000341243#ENSG00000124232#ENST00000343694#LAG1, DNA binding#BTD$#ENSP00000483978#ENSG00000124232#ENST00000464504#LAG1, DNA binding#BTD	FALSE
1072	ENSG00000257923	CUX1	CUT; Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003350;IPR009057;IPR010982;IPR012955;IPR017970	1523	cut like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2557]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10864926;15994318	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000292535#ENSG00000257923#ENST00000292535#CUT, Homeodomain#$#ENSP00000292538#ENSG00000257923#ENST00000292538#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000353401#ENSG00000257923#ENST00000360264#CUT, Homeodomain#$#ENSP00000414091#ENSG00000257923#ENST00000437600#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000484760#ENSG00000257923#ENST00000622516#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000377410#ENSG00000257923#ENST00000393824#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000409745#ENSG00000257923#ENST00000425244#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10$#ENSP00000449371#ENSG00000257923#ENST00000547394#CUT, Homeodomain#CASP_C, DUF2205, NPV_P10	FALSE
1073	ENSG00000111249	CUX2	CUT; Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003350;IPR009057;IPR010982;IPR017970;	23316	cut like homeobox 2 [Source:HGNC Symbol;Acc:HGNC:19347]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798433;15656993	No	1a1, Direct HQ evidence	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000111249#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000261726#ENSG00000111249#ENST00000261726#CUT, Homeodomain#DUF4618$#ENSP00000380765#ENSG00000111249#ENST00000397643#CUT, Homeodomain#	FALSE
1074	ENSG00000169856	ONECUT1	CUT; Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003350;IPR009057;IPR010982	3175	one cut homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8138]	2D5V	DBD and Full	not tested	None	The structure has both the CUT and homeodomain	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15581617;16618419	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000169856#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000302630#ENSG00000169856#ENST00000305901#CUT, Homeodomain#$#ENSP00000453718#ENSG00000169856#ENST00000560699#CUT, Homeodomain#	FALSE
1075	ENSG00000119547	ONECUT2	CUT; Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003350;IPR009057;IPR010982	9480	one cut homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8139]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9915796	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000119547#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11478782	$#ENSP00000419185#ENSG00000119547#ENST00000491143#CUT, Homeodomain#	FALSE
1076	ENSG00000205922	ONECUT3	CUT; Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003350;IPR009057;IPR010982	390874	one cut homeobox 3 [Source:HGNC Symbol;Acc:HGNC:13399]	None	DBD	not tested	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding; Transactivation_PMIDS:11944891;11944891	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000205922#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000371786#ENSG00000205922#ENST00000382349#CUT, Homeodomain#	FALSE
1077	ENSG00000182568	SATB1	CUT; Homeodomain	Yes	Known motif	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).	IPR001356;IPR003350;IPR009057;IPR010982	6304	SATB homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10541]	2O49	DBD and Full	not tested	None	Structure has only the CUT-domain of the protein	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1505028;8114718;9340009	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000182568#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15851481	$#ENSP00000341024#ENSG00000182568#ENST00000338745#CUT, Homeodomain#CUTL, ULD$#ENSP00000399518#ENSG00000182568#ENST00000417717#CUT, Homeodomain#CUTL, SUIM_assoc, ULD$#ENSP00000399708#ENSG00000182568#ENST00000454909#CUT, Homeodomain#CUTL, ULD$#ENSP00000479866#ENSG00000182568#ENST00000491519#CUT, Homeodomain#CUTL, RuvA_C, ULD$#ENSP00000408871#ENSG00000182568#ENST00000414509#CUT, Homeodomain#ULD$#ENSP00000390529#ENSG00000182568#ENST00000415069#CUT, Homeodomain#ULD$#ENSP00000453908#ENSG00000182568#ENST00000493952#CUT, Homeodomain#	FALSE
1078	ENSG00000119042	SATB2	CUT; Homeodomain	Yes	Inferred motif	Low specificity DNA-binding protein	In vivo/Misc source	None	SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).	IPR001356;IPR003350;IPR009057;IPR010982	23314	SATB homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21637]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701874	No	2a2, orthologous lower confidence evidence	Laura Campitelli	Tim Hughes	Yes	None	$#ENSP00000260926#ENSG00000119042#ENST00000260926#CUT, Homeodomain#CUTL, ULD$#ENSP00000388581#ENSG00000119042#ENST00000428695#CUT, Homeodomain#ULD$#ENSP00000401112#ENSG00000119042#ENST00000417098#CUT, Homeodomain#CUTL, ULD$#ENSP00000405420#ENSG00000119042#ENST00000457245#CUT, Homeodomain#CUTL, ULD	FALSE
1079	ENSG00000154832	CXXC1	CxxC	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID: 21407193).	IPR001965;IPR002857;IPR011011;IPR019786;IPR019787;IPR022056	30827	CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343]	3QMI	not tested	not tested	None	Structure has many contacts between the AA-residues and the DNA-bases in the major groove, could well be sequence-specific	other	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000285106#ENSG00000154832#ENST00000285106#CxxC#PHD, zf-CpG_bind_C$#ENSP00000390475#ENSG00000154832#ENST00000412036#CxxC#PHD, zf-CpG_bind_C$#ENSP00000467634#ENSG00000154832#ENST00000589940#CxxC#PHD, zf-CpG_bind_C$#ENSP00000468038#ENSG00000154832#ENST00000589548#CxxC#PHD, PHD_2$#ENSP00000465849#ENSG00000154832#ENST00000591474#CxxC#	FALSE
1080	ENSG00000168772	CXXC4	CxxC	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds unmethylated CpG-rich sequences: (PMID: 23563267).	IPR002857;	80319	CXXC finger protein 4 [Source:HGNC Symbol;Acc:HGNC:24593]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$#ENSP00000378248#ENSG00000168772#ENST00000394767#CxxC#	FALSE
1081	ENSG00000171604	CXXC5	CxxC	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002857;	51523	CXXC finger protein 5 [Source:HGNC Symbol;Acc:HGNC:26943]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000302543#ENSG00000171604#ENST00000302517#CxxC#$#ENSP00000424219#ENSG00000171604#ENST00000502716#CxxC#$#ENSP00000421057#ENSG00000171604#ENST00000503511#CxxC#$#ENSP00000425203#ENSG00000171604#ENST00000504844#CxxC#$#ENSP00000427440#ENSG00000171604#ENST00000509238#CxxC#$#ENSP00000427379#ENSG00000171604#ENST00000511048#CxxC#$#ENSP00000422883#ENSG00000171604#ENST00000504944#CxxC#$#ENSP00000430949#ENSG00000171604#ENST00000511457#CxxC#$#ENSP00000421866#ENSG00000171604#ENST00000511591#CxxC#$#ENSP00000423365#ENSG00000171604#ENST00000512816#CxxC#$#ENSP00000430522#ENSG00000171604#ENST00000520967#CxxC#	FALSE
1082	ENSG00000130816	DNMT1	CxxC	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001025;IPR001525;IPR002857;IPR010506;IPR017198;IPR018117;IPR022702;IPR029063	1786	DNA (cytosine-5-)-methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976]	4DA4	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000345739#ENSG00000130816#ENST00000340748#CxxC#BAH, DMAP_binding, DNA_methylase, DNMT1-RFD$#ENSP00000352516#ENSG00000130816#ENST00000359526#CxxC#BAH, DMAP_binding, DNA_methylase, DNMT1-RFD$#ENSP00000468062#ENSG00000130816#ENST00000590619#CxxC#$#ENSP00000465555#ENSG00000130816#ENST00000586800#CxxC#$#ENSP00000465993#ENSG00000130816#ENST00000592342#CxxC#	FALSE
1083	ENSG00000099364	FBXL19	CxxC	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001611;IPR001810;IPR001965;IPR002857;IPR006553;IPR011011;IPR019786;IPR019787	54620	F-box and leucine rich repeat protein 19 [Source:HGNC Symbol;Acc:HGNC:25300]	None	not tested	Yes	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Tim Hughes	No	None	$#ENSP00000397913#ENSG00000099364#ENST00000427128#CxxC#F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4$#ENSP00000369666#ENSG00000099364#ENST00000380310#CxxC#F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4$#ENSP00000458033#ENSG00000099364#ENST00000471231#CxxC#F-box, F-box-like, LRR_1, LRR_4, LRR_6, LRR_8$#ENSP00000455529#ENSG00000099364#ENST00000562319#CxxC#F-box, F-box-like, LRR_4, LRR_6, LRR_8, PHD, PHD_4$#ENSP00000457199#ENSG00000099364#ENST00000565939#CxxC#	FALSE
1084	ENSG00000173120	KDM2A	CxxC	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a CXXC zinc finger that recognizes CGs (PMID: 22083960)	IPR001810;IPR001965;IPR002857;IPR003347;IPR006553;IPR011011;IPR019786;IPR019787	22992	lysine demethylase 2A [Source:HGNC Symbol;Acc:HGNC:13606]	None	not tested	not tested	Chromatin_Modifier_etc	Lysine-specific demethylase 2A	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	Yes	None	$#ENSP00000309302#ENSG00000173120#ENST00000308783#CxxC#Cupin_8, F-box, F-box-like, JmjC, LRR_6, PHD_4$#ENSP00000381640#ENSG00000173120#ENST00000398645#CxxC#Cupin_8, JmjC, PHD_4$#ENSP00000432786#ENSG00000173120#ENST00000529006#CxxC#Cupin_8, F-box, F-box-like, JmjC, LRR_6, PHD_4$#ENSP00000435776#ENSG00000173120#ENST00000530342#CxxC#F-box, F-box-like, LRR_6, PHD_4	FALSE
1085	ENSG00000089094	KDM2B	CxxC	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001810;IPR001965;IPR002857;IPR003347;IPR006553;IPR011011;IPR019787;	102465665	lysine demethylase 2B [Source:HGNC Symbol;Acc:HGNC:13610]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000366271#ENSG00000089094#ENST00000377071#CxxC#Cupin_8, F-box, F-box-like, JmjC, PHD, PHD_4$#ENSP00000445196#ENSG00000089094#ENST00000536437#CxxC#Cupin_8, JmjC, PHD_4$#ENSP00000474307#ENSG00000089094#ENST00000538046#CxxC#$#ENSP00000366269#ENSG00000089094#ENST00000377069#CxxC#Cupin_8, F-box, F-box-like, JmjC, PHD, PHD_4$#ENSP00000437821#ENSG00000089094#ENST00000542973#CxxC#F-box, F-box-like, LRR_6, LRR_8, PHD, PHD_4	FALSE
1086	ENSG00000138336	TET1	CxxC	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002857;IPR024779	80312	tet methylcytosine dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:29484]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	None	$#ENSP00000362748#ENSG00000138336#ENST00000373644#CxxC#Tet_JBP	FALSE
1087	ENSG00000187605	TET3	CxxC	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR002857;IPR024779	200424	tet methylcytosine dioxygenase 3 [Source:HGNC Symbol;Acc:HGNC:28313]	4HP1	not tested	not tested	None	None	No	Yes	No	No	3a, decent circumstantial evidence for its role as	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000386869#ENSG00000187605#ENST00000409262#CxxC#Tet_JBP$#ENSP00000307803#ENSG00000187605#ENST00000305799#CxxC#Tet_JBP	FALSE
1088	ENSG00000118058	KMT2A	CxxC; AT hook	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Contains 3 AT-hook domain, a CXXC domain, and a possible C2H2 domain.	IPR001214;IPR001487;IPR001965;IPR002857;IPR003616;IPR003888;IPR003889;IPR011011;IPR016569;IPR019787	4297	lysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132]	None	not tested	Yes	None	None	c	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12453418	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000118058#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10821850	$#ENSP00000374157#ENSG00000118058#ENST00000389506#CxxC#Bromodomain, FYRC, FYRN, PHD, PHD_2, SET, zf-HC5HC$#ENSP00000376612#ENSG00000118058#ENST00000392873#CxxC#PHD, PHD_2, PHD_4, zf-PHD-like$#ENSP00000436786#ENSG00000118058#ENST00000534358#CxxC#Bromodomain, FYRC, FYRN, PHD, PHD_2, SET, zf-HC5HC$#ENSP00000436564#ENSG00000118058#ENST00000529852#CxxC#$#ENSP00000432391#ENSG00000118058#ENST00000531904#CxxC#$#ENSP00000434618#ENSG00000118058#ENST00000532204#CxxC#$#ENSP00000436700#ENSG00000118058#ENST00000533790#CxxC#$#ENSP00000432652#ENSG00000118058#ENST00000527869#CxxC#	FALSE
1089	ENSG00000272333	KMT2B	CxxC; AT hook	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Structural evidence shows direct DNA-binding (PDB:4PZI) and KMT2B appears to make specific contacts with methylated DNA.	IPR001214;IPR001965;IPR002857;IPR003616;IPR003888;IPR003889;IPR011011;IPR016569;IPR019787	9757	lysine methyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:15840]	4PZI	not tested	not tested	None	Protein contacts the DNA, could well be sequence specific	No	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000272333#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10409430	$#ENSP00000398837#ENSG00000272333#ENST00000420124#CxxC#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2	FALSE
1090	ENSG00000137090	DMRT1	DM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001275;IPR022114	1761	doublesex and mab-3 related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2934]	4YJ0	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000137090#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000137090#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000371711#ENSG00000137090#ENST00000382276#DM#Dmrt1$#ENSP00000454701#ENSG00000137090#ENST00000569227#DM#Dmrt1	FALSE
1091	ENSG00000173253	DMRT2	DM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001275;	10655	doublesex and mab-3 related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2935]	None	DBD	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000173253#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000350865#ENSG00000173253#ENST00000358146#DM#$#ENSP00000371690#ENSG00000173253#ENST00000382255#DM#$#ENSP00000397494#ENSG00000173253#ENST00000412350#DM#$#ENSP00000259622#ENSG00000173253#ENST00000259622#DM#	FALSE
1092	ENSG00000064218	DMRT3	DM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001275;IPR005173;IPR009060;	58524	doublesex and mab-3 related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:13909]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000064218#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000190165#ENSG00000064218#ENST00000190165#DM#DMA$#ENSP00000387472#ENSG00000064218#ENST00000417254#DM#	FALSE
1093	ENSG00000176399	DMRTA1	DM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001275;IPR005173;IPR009060;	63951	DMRT like family A1 [Source:HGNC Symbol;Acc:HGNC:13826]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000176399#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000319651#ENSG00000176399#ENST00000325870#DM#DMA	FALSE
1094	ENSG00000142700	DMRTA2	DM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001275;IPR005173;IPR009060;	63950	DMRT like family A2 [Source:HGNC Symbol;Acc:HGNC:13908]	None	DBD	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000142700#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000399370#ENSG00000142700#ENST00000418121#DM#DMA$#ENSP00000383909#ENSG00000142700#ENST00000404795#DM#DMA	FALSE
1095	ENSG00000143006	DMRTB1	DM	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	None	IPR001275;	63948	DMRT like family B with proline rich C-terminal 1 [Source:HGNC Symbol;Acc:HGNC:13913]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000143006#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000360500#ENSG00000143006#ENST00000371445#DM#	FALSE
1096	ENSG00000142025	DMRTC2	DM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001275;	63946	DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911]	None	DBD and Full	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000142025#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000269945#ENSG00000142025#ENST00000269945#DM#DMRT-like$#ENSP00000469525#ENSG00000142025#ENST00000596827#DM#DMRT-like	FALSE
1097	ENSG00000101412	E2F1	E2F	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003316;	1869	E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113]	None	DBD and Full	Yes	None	Prefers heterodimer with TFDP proteins over homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16741925;17178835	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000101412#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15731768 | TAS - PMID:11418595	$#ENSP00000345571#ENSG00000101412#ENST00000343380#E2F#E2F_CC-MB	FALSE
1098	ENSG00000007968	E2F2	E2F	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Can also bind as a heterodimer with DP1 (PMID: 16360038)	IPR003316;	1870	E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114]	None	DBD and Full	Yes	None	Prefers heterodimer with TFDP proteins over homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10766737;11883935	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000007968#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000355249#ENSG00000007968#ENST00000361729#E2F#E2F_CC-MB	FALSE
1099	ENSG00000112242	E2F3	E2F	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Binds preferentially with DP proteins in vivo	IPR003316;	1871	E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115]	None	DBD and Full	Yes	None	Prefers heterodimer with TFDP proteins over homodimer	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Co-activation_PMIDS:15448153;17135268	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000112242#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000262904#ENSG00000112242#ENST00000346618#E2F#E2F_CC-MB$#ENSP00000443418#ENSG00000112242#ENST00000535432#E2F#E2F_CC-MB$#ENSP00000483249#ENSG00000112242#ENST00000613242#E2F#	FALSE
1100	ENSG00000205250	E2F4	E2F	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003316;	1874	E2F transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:3118]	1CF7	DBD	Yes	None	Prefers heterodimer with TFDP proteins over homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:12110166	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000205250#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000205250#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11418595	$#ENSP00000368686#ENSG00000205250#ENST00000379378#E2F#E2F_CC-MB$#ENSP00000458706#ENSG00000205250#ENST00000565226#E2F#	FALSE
1101	ENSG00000133740	E2F5	E2F	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Also heterodimerzes with DP2  (PMID: 7760804)	IPR003316;	1875	E2F transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3119]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:7760804	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000133740#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000398124#ENSG00000133740#ENST00000416274#E2F#E2F_CC-MB$#ENSP00000414312#ENSG00000133740#ENST00000418930#E2F#E2F_CC-MB$#ENSP00000429120#ENSG00000133740#ENST00000517476#E2F#E2F_CC-MB$#ENSP00000430461#ENSG00000133740#ENST00000520225#E2F#	FALSE
1102	ENSG00000169016	E2F6	E2F	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR003316;	1876	E2F transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:3120]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15574595;15936277	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000169016#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000302159#ENSG00000169016#ENST00000307236#E2F#E2F_CC-MB$#ENSP00000370936#ENSG00000169016#ENST00000381525#E2F#E2F_CC-MB$#ENSP00000446315#ENSG00000169016#ENST00000542100#E2F#E2F_CC-MB$#ENSP00000438864#ENSG00000169016#ENST00000546212#E2F#E2F_CC-MB	FALSE
1103	ENSG00000165891	E2F7	E2F	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003316;	144455	E2F transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:23820]	None	DBD and Full	not tested	None	None	c	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12893818;14633988	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000165891#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000165891#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:22802528 | IMP - PMID:22903062	$#ENSP00000323246#ENSG00000165891#ENST00000322886#E2F#$#ENSP00000448245#ENSG00000165891#ENST00000550669#E2F#$#ENSP00000449284#ENSG00000165891#ENST00000551058#E2F#$#ENSP00000449033#ENSG00000165891#ENST00000547316#E2F#	FALSE
1104	ENSG00000129173	E2F8	E2F	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003316;	79733	E2F transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24727]	4YO2	DBD and Full	not tested	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000129173#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16179649$#ENSG00000129173#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:22903062	$#ENSP00000250024#ENSG00000129173#ENST00000250024#E2F#$#ENSP00000437326#ENSG00000129173#ENST00000532666#E2F#$#ENSP00000434199#ENSG00000129173#ENST00000527884#E2F#$#ENSP00000481103#ENSG00000129173#ENST00000620009#E2F#	FALSE
1105	ENSG00000198176	TFDP1	E2F	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR003316;IPR014889;IPR015648;	7027	transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749]	None	DBD and Full	Yes	Obligate_Multimer	Well established to make heterodimers with E2F-TFs	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8446173	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000198176#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000198176#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8405995	$#ENSP00000364519#ENSG00000198176#ENST00000375370#E2F#$#ENSP00000401389#ENSG00000198176#ENST00000453989#E2F#$#ENSP00000386145#ENSG00000198176#ENST00000408980#E2F#	FALSE
1106	ENSG00000114126	TFDP2	E2F	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	None	IPR003316;IPR014889;IPR015648;	7029	transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751]	1CF7	DBD and Full	not tested	Obligate_Multimer	The structure is E2F4 - TFDP2 heterodimer; compulsory heterodimer with E2F-proteins	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:7478568;7784053;10090723	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000114126#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000114126#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7784053	$#ENSP00000418590#ENSG00000114126#ENST00000467072#E2F#$#ENSP00000417585#ENSG00000114126#ENST00000479040#E2F#$#ENSP00000420599#ENSG00000114126#ENST00000486111#E2F#$#ENSP00000420616#ENSG00000114126#ENST00000489671#E2F#$#ENSP00000420657#ENSG00000114126#ENST00000494358#E2F#$#ENSP00000439782#ENSG00000114126#ENST00000499676#E2F#$#ENSP00000419507#ENSG00000114126#ENST00000474279#E2F#$#ENSP00000418971#ENSG00000114126#ENST00000477292#E2F#$#ENSP00000419036#ENSG00000114126#ENST00000495310#E2F#$#ENSP00000417726#ENSG00000114126#ENST00000467667#E2F#$#ENSP00000418122#ENSG00000114126#ENST00000478006#E2F#$#ENSP00000417220#ENSG00000114126#ENST00000497579#E2F#	FALSE
1107	ENSG00000183434	TFDP3	E2F	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Interacts with E2F1; E2F2; E2F3; E2F4 and E2F5 (PMID: 17062573).	IPR003316;IPR014889;IPR015648;	51270	transcription factor Dp family member 3 [Source:HGNC Symbol;Acc:HGNC:24603]	None	DBD and Full	not tested	None	Heterodimerizes with E2F proteins	b	Yes	No	Yes	2a2, orthologous lower confidence evidence	Sam Lambert	Arttu Jolma	No	$#ENSG00000183434#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000385461#ENSG00000183434#ENST00000310125#E2F#	FALSE
1108	ENSG00000164330	EBF1	EBF1	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002909;IPR014756;IPR018350;	1879	early B-cell factor 1 [Source:HGNC Symbol;Acc:HGNC:3126]	3MLN	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:12446773	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000164330#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000322898#ENSG00000164330#ENST00000313708#COE1 DBD#COE1_HLH, TIG$#ENSP00000370029#ENSG00000164330#ENST00000380654#COE1 DBD#COE1_HLH, TIG$#ENSP00000428020#ENSG00000164330#ENST00000517373#COE1 DBD#COE1_HLH, TIG$#ENSP00000477809#ENSG00000164330#ENST00000622875#COE1 DBD#COE1_HLH, TIG	FALSE
1109	ENSG00000221818	EBF2	EBF1	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	EBF1 has a nice HT-SELEX model and based on this paper (PMID:23499423). EBF2 binds similar motif to control brown/beige fat cell identity.	IPR002909;IPR014756;IPR018350;	64641	early B-cell factor 2 [Source:HGNC Symbol;Acc:HGNC:19090]	None	DBD	Yes	None	EBF1 has a nice HT-SELEX model and based on this paper PMID:23499423 EBF2 binds similar motif to control brown/beige fat cell identity	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000221818#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000386178#ENSG00000221818#ENST00000408929#COE1 DBD#COE1_HLH, TIG$#ENSP00000430241#ENSG00000221818#ENST00000520164#COE1 DBD#COE1_HLH, TIG$#ENSP00000437909#ENSG00000221818#ENST00000535548#COE1 DBD#COE1_HLH	FALSE
1110	ENSG00000108001	EBF3	EBF1	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR002909;IPR014756;IPR018350;	253738	early B-cell factor 3 [Source:HGNC Symbol;Acc:HGNC:19087]	None	DBD and Full	Yes	None	EBF1 has a nice HT-SELEX model and based on this paper PMID:23499423 EBF2 binds similar motif to control brown/beige fat cell identity	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000108001#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000357637#ENSG00000108001#ENST00000368648#COE1 DBD#COE1_HLH, TIG$#ENSP00000387543#ENSG00000108001#ENST00000440978#COE1 DBD#$#ENSP00000347463#ENSG00000108001#ENST00000355311#COE1 DBD#COE1_HLH, TIG	FALSE
1111	ENSG00000088881	EBF4	EBF1	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR002909;IPR014756;IPR018350;	57593	early B-cell factor 4 [Source:HGNC Symbol;Acc:HGNC:29278]	None	DBD and Full	Yes	None	EBF1 has a nice HT-SELEX model and based on this paper PMID:23499423 EBF2 binds similar motif to control brown/beige fat cell identity	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000088881#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000345030#ENSG00000088881#ENST00000342725#COE1 DBD#COE1_HLH, TIG$#ENSP00000370022#ENSG00000088881#ENST00000380648#COE1 DBD#COE1_HLH, TIG$#ENSP00000477107#ENSG00000088881#ENST00000463145#COE1 DBD#$#ENSP00000477023#ENSG00000088881#ENST00000609451#COE1 DBD#COE1_HLH, TIG	FALSE
1112	ENSG00000135373	EHF	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	26298	ETS homologous factor [Source:HGNC Symbol;Acc:HGNC:3246]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10644770;17027647	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000135373#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17027647$#ENSG00000135373#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644770	$#ENSP00000257831#ENSG00000135373#ENST00000257831#ETS#SAM_PNT$#ENSP00000399733#ENSG00000135373#ENST00000450654#ETS#SAM_PNT$#ENSP00000433508#ENSG00000135373#ENST00000530286#ETS#SAM_PNT$#ENSP00000435835#ENSG00000135373#ENST00000531794#ETS#SAM_PNT$#ENSP00000435837#ENSG00000135373#ENST00000533754#ETS#SAM_PNT$#ENSP00000436158#ENSG00000135373#ENST00000527935#ETS#SAM_PNT$#ENSP00000436357#ENSG00000135373#ENST00000531728#ETS#SAM_PNT	FALSE
1113	ENSG00000120690	ELF1	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR022084	1997	E74 like ETS transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3316]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:12065417;16002702	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000120690#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8756667$#ENSG00000120690#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14970218	$#ENSP00000239882#ENSG00000120690#ENST00000239882#ETS#Elf-1_N$#ENSP00000405580#ENSG00000120690#ENST00000442101#ETS#$#ENSP00000384135#ENSG00000120690#ENST00000405737#ETS#Elf-1_N$#ENSP00000486912#ENSG00000120690#ENST00000625359#ETS#Elf-1_N	FALSE
1114	ENSG00000109381	ELF2	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR022084	1998	E74 like ETS transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3317]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8756667	Yes	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	$#ENSG00000109381#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000351458#ENSG00000109381#ENST00000358635#ETS#Elf-1_N$#ENSP00000397796#ENSG00000109381#ENST00000420916#ETS#Elf-1_N$#ENSP00000426997#ENSG00000109381#ENST00000510408#ETS#Elf-1_N$#ENSP00000368867#ENSG00000109381#ENST00000379549#ETS#Elf-1_N$#ENSP00000426087#ENSG00000109381#ENST00000512627#ETS#Elf-1_N	FALSE
1115	ENSG00000102034	ELF4	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR022084	2000	E74 like ETS transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:3319]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8895518	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000102034#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:14625302	$#ENSP00000311280#ENSG00000102034#ENST00000308167#ETS#Elf-1_N$#ENSP00000338608#ENSG00000102034#ENST00000335997#ETS#Elf-1_N$#ENSP00000407572#ENSG00000102034#ENST00000434609#ETS#Elf-1_N$#ENSP00000478297#ENSG00000102034#ENST00000615377#ETS#Elf-1_N	FALSE
1116	ENSG00000135374	ELF5	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	2001	E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9840936;10506207	Yes	1a1, Direct HQ evidence	Sam Lambert	Tim Hughes	Yes	$#ENSG00000135374#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000135374#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000257832#ENSG00000135374#ENST00000257832#ETS#SAM_PNT$#ENSP00000311010#ENSG00000135374#ENST00000312319#ETS#SAM_PNT$#ENSP00000407589#ENSG00000135374#ENST00000429939#ETS#$#ENSP00000436386#ENSG00000135374#ENST00000532417#ETS#SAM_PNT	FALSE
1117	ENSG00000126767	ELK1	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	2002	ELK1, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3321]	1DUX	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:11151091;15808854	Yes	1a1, Direct HQ evidence	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000126767#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12750007$#ENSG00000126767#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14970218	$#ENSP00000247161#ENSG00000126767#ENST00000247161#ETS#$#ENSP00000345585#ENSG00000126767#ENST00000343894#ETS#$#ENSP00000366182#ENSG00000126767#ENST00000376983#ETS#	FALSE
1118	ENSG00000111145	ELK3	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	2004	ELK3, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3325]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7958835;12896968	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000111145#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12788937$#ENSG00000111145#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7851904	$#ENSP00000228741#ENSG00000111145#ENST00000228741#ETS#$#ENSP00000446806#ENSG00000111145#ENST00000547249#ETS#$#ENSP00000447857#ENSG00000111145#ENST00000547860#ETS#$#ENSP00000449430#ENSG00000111145#ENST00000552142#ETS#	FALSE
1119	ENSG00000158711	ELK4	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	2005	ELK4, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3326]	1BC7	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8524663	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000158711#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000158711#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7851904	$#ENSP00000289703#ENSG00000158711#ENST00000289703#ETS#$#ENSP00000350681#ENSG00000158711#ENST00000357992#ETS#$#ENSP00000484946#ENSG00000158711#ENST00000468523#ETS#	FALSE
1120	ENSG00000105722	ERF	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	2077	ETS2 repressor factor [Source:HGNC Symbol;Acc:HGNC:3444]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12533699	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000105722#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000222329#ENSG00000105722#ENST00000222329#ETS#$#ENSP00000388173#ENSG00000105722#ENST00000440177#ETS#$#ENSP00000468962#ENSG00000105722#ENST00000598965#ETS#$#ENSP00000469274#ENSG00000105722#ENST00000593944#ETS#	FALSE
1121	ENSG00000157554	ERG	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	2078	ERG, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3446]	4IRI	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000157554#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000288319#ENSG00000157554#ENST00000288319#ETS#SAM_PNT$#ENSP00000381871#ENSG00000157554#ENST00000398897#ETS#SAM_PNT$#ENSP00000381877#ENSG00000157554#ENST00000398905#ETS#SAM_PNT$#ENSP00000381891#ENSG00000157554#ENST00000398919#ETS#SAM_PNT$#ENSP00000414150#ENSG00000157554#ENST00000417133#ETS#SAM_PNT$#ENSP00000396268#ENSG00000157554#ENST00000453032#ETS#SAM_PNT	FALSE
1122	ENSG00000134954	ETS1	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;IPR016311	2113	ETS proto-oncogene 1, transcription factor [Source:HGNC Symbol;Acc:HGNC:3488]	1K78	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: non-sequence-specific_DNA Binding; Transactivation_PMIDS:12119294	Yes	1a1, Direct HQ evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000134954#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000134954#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21711453$#ENSG00000134954#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11909962, PMID:15247905	$#ENSP00000324578#ENSG00000134954#ENST00000319397#ETS#SAM_PNT$#ENSP00000376436#ENSG00000134954#ENST00000392668#ETS#SAM_PNT$#ENSP00000435666#ENSG00000134954#ENST00000531611#ETS#SAM_PNT$#ENSP00000441430#ENSG00000134954#ENST00000535549#ETS#	FALSE
1123	ENSG00000157557	ETS2	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;IPR016311;IPR027276;	2114	ETS proto-oncogene 2, transcription factor [Source:HGNC Symbol;Acc:HGNC:3489]	4BQA	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12637547;12928043	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000157557#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12637547$#ENSG00000157557#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11909962	$#ENSP00000354194#ENSG00000157557#ENST00000360938#ETS#SAM_PNT$#ENSP00000353344#ENSG00000157557#ENST00000360214#ETS#SAM_PNT$#ENSP00000411086#ENSG00000157557#ENST00000456966#ETS#SAM_PNT$#ENSP00000401273#ENSG00000157557#ENST00000432278#ETS#SAM_PNT	FALSE
1124	ENSG00000006468	ETV1	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR006715	2115	ETS variant 1 [Source:HGNC Symbol;Acc:HGNC:3490]	4BNC	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12750007	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000006468#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12750007$#ENSG00000006468#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7700648	$#ENSP00000384138#ENSG00000006468#ENST00000403527#ETS#ETS_PEA3_N$#ENSP00000385686#ENSG00000006468#ENST00000403685#ETS#ETS_PEA3_N$#ENSP00000385381#ENSG00000006468#ENST00000405192#ETS#ETS_PEA3_N$#ENSP00000405327#ENSG00000006468#ENST00000430479#ETS#ETS_PEA3_N$#ENSP00000393078#ENSG00000006468#ENST00000438956#ETS#ETS_PEA3_N$#ENSP00000382293#ENSG00000006468#ENST00000399357#ETS#ETS_PEA3_N$#ENSP00000411626#ENSG00000006468#ENST00000420159#ETS#ETS_PEA3_N	FALSE
1125	ENSG00000105672	ETV2	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	2116	ETS variant 2 [Source:HGNC Symbol;Acc:HGNC:3491]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000105672#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000105672#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000368309#ENSG00000105672#ENST00000379023#ETS#$#ENSP00000384524#ENSG00000105672#ENST00000402764#ETS#$#ENSP00000468453#ENSG00000105672#ENST00000479824#ETS#$#ENSP00000368312#ENSG00000105672#ENST00000379026#ETS#$#ENSP00000385369#ENSG00000105672#ENST00000403402#ETS#$#ENSP00000475089#ENSG00000105672#ENST00000591135#ETS#	FALSE
1126	ENSG00000117036	ETV3	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	2117	ETS variant 3 [Source:HGNC Symbol;Acc:HGNC:3492]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12007404	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000117036#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000117036#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000327316#ENSG00000117036#ENST00000326786#ETS#$#ENSP00000357175#ENSG00000117036#ENST00000368192#ETS#	FALSE
1127	ENSG00000253831	ETV3L	Ets	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000418	440695	ETS variant 3 like [Source:HGNC Symbol;Acc:HGNC:33834]	None	not tested	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000253831#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000253831#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000002	$#ENSP00000430271#ENSG00000253831#ENST00000454449#ETS#	FALSE
1128	ENSG00000175832	ETV4	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR006715	2118	ETS variant 4 [Source:HGNC Symbol;Acc:HGNC:3493]	4UUV	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15138262;15466854	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000175832#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000175832#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036	$#ENSP00000321835#ENSG00000175832#ENST00000319349#ETS#ETS_PEA3_N$#ENSP00000377273#ENSG00000175832#ENST00000393664#ETS#ETS_PEA3_N$#ENSP00000468636#ENSG00000175832#ENST00000586826#ETS#ETS_PEA3_N$#ENSP00000465718#ENSG00000175832#ENST00000591713#ETS#ETS_PEA3_N$#ENSP00000443846#ENSG00000175832#ENST00000538265#ETS#ETS_PEA3_N$#ENSP00000441749#ENSG00000175832#ENST00000545089#ETS#ETS_PEA3_N$#ENSP00000440023#ENSG00000175832#ENST00000545954#ETS#ETS_PEA3_N$#ENSP00000466673#ENSG00000175832#ENST00000586764#ETS#ETS_PEA3_N	FALSE
1129	ENSG00000244405	ETV5	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR006715	2119	ETS variant 5 [Source:HGNC Symbol;Acc:HGNC:3494]	4UNO	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15138262;15466854;15857832	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000244405#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:15857832$#ENSG00000244405#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19443906	$#ENSP00000306894#ENSG00000244405#ENST00000306376#ETS#ETS_PEA3_N$#ENSP00000413755#ENSG00000244405#ENST00000434744#ETS#ETS_PEA3_N$#ENSP00000412171#ENSG00000244405#ENST00000421809#ETS#ETS_PEA3_N	FALSE
1130	ENSG00000139083	ETV6	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	2120	ETS variant 6 [Source:HGNC Symbol;Acc:HGNC:3495]	4MHG	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000139083#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000139083#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000139083#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000139083#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7761424	$#ENSP00000379658#ENSG00000139083#ENST00000396373#ETS#SAM_PNT$#ENSP00000266427#ENSG00000139083#ENST00000266427#ETS#$#ENSP00000441463#ENSG00000139083#ENST00000545027#ETS#SAM_PNT	FALSE
1131	ENSG00000010030	ETV7	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID: 11108721)	IPR000418;IPR003118;IPR013761;	51513	ETS variant 7 [Source:HGNC Symbol;Acc:HGNC:18160]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000010030#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11108721	$#ENSP00000342260#ENSG00000010030#ENST00000339796#ETS#SAM_PNT$#ENSP00000341843#ENSG00000010030#ENST00000340181#ETS#SAM_PNT$#ENSP00000362842#ENSG00000010030#ENST00000373737#ETS#SAM_PNT$#ENSP00000362843#ENSG00000010030#ENST00000373738#ETS#$#ENSP00000481885#ENSG00000010030#ENST00000615781#ETS#$#ENSP00000484485#ENSG00000010030#ENST00000620358#ETS#SAM_PNT$#ENSP00000486712#ENSG00000010030#ENST00000627426#ETS#$#ENSP00000440592#ENSG00000010030#ENST00000538992#ETS#	FALSE
1132	ENSG00000163497	FEV	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	54738	FEV, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:18562]	3ZP5	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9468386	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000163497#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000163497#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9121764	$#ENSP00000295727#ENSG00000163497#ENST00000295727#ETS#	FALSE
1133	ENSG00000151702	FLI1	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	2313	Fli-1 proto-oncogene, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:3749]	5E8I	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1445800;1522903;8449942;8502483;12065417;14570912	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000151702#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000151702#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000151702#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10891501	$#ENSP00000281428#ENSG00000151702#ENST00000281428#ETS#SAM_PNT$#ENSP00000433488#ENSG00000151702#ENST00000527786#ETS#SAM_PNT$#ENSP00000339627#ENSG00000151702#ENST00000344954#ETS#$#ENSP00000432950#ENSG00000151702#ENST00000534087#ETS#SAM_PNT	FALSE
1134	ENSG00000154727	GABPA	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;IPR016312;IPR024668;IPR029071	2551	GA binding protein transcription factor alpha subunit [Source:HGNC Symbol;Acc:HGNC:4071]	1AWC	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10773883;15361867	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000154727#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12750007$#ENSG00000154727#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:22306510$#ENSG00000154727#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7590737, PMID:8441384	$#ENSP00000346886#ENSG00000154727#ENST00000354828#ETS#GABP-alpha, SAM_PNT$#ENSP00000382948#ENSG00000154727#ENST00000400075#ETS#GABP-alpha, SAM_PNT	FALSE
1135	ENSG00000124664	SPDEF	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	25803	SAM pointed domain containing ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:17257]	1YO5	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:10625666	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000124664#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000363149#ENSG00000124664#ENST00000374037#ETS#SAM_PNT$#ENSP00000442715#ENSG00000124664#ENST00000544425#ETS#SAM_PNT	FALSE
1136	ENSG00000066336	SPI1	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	6688	Spi-1 proto-oncogene [Source:HGNC Symbol;Acc:HGNC:11241]	1PUE	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9211934;10523830;7624145	Yes	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000066336#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000066336#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066336#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066336#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000066336#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12833137$#ENSG00000066336#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000367799#ENSG00000066336#ENST00000378538#ETS#$#ENSP00000438846#ENSG00000066336#ENST00000533968#ETS#$#ENSP00000227163#ENSG00000066336#ENST00000227163#ETS#p47_phox_C$#ENSP00000443865#ENSG00000066336#ENST00000533030#ETS#	FALSE
1137	ENSG00000269404	SPIB	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR006134;IPR025687;	6689	Spi-B transcription factor [Source:HGNC Symbol;Acc:HGNC:11242]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1406622	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000269404#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000270632#ENSG00000269404#ENST00000270632#ETS#$#ENSP00000471921#ENSG00000269404#ENST00000595883#ETS#$#ENSP00000391877#ENSG00000269404#ENST00000439922#ETS#$#ENSP00000470970#ENSG00000269404#ENST00000596074#ETS#$#ENSP00000472626#ENSG00000269404#ENST00000594685#ETS#	FALSE
1138	ENSG00000166211	SPIC	Ets	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;	121599	Spi-C transcription factor [Source:HGNC Symbol;Acc:HGNC:29549]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12749910	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000166211#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000448580#ENSG00000166211#ENST00000551346#ETS#	FALSE
1139	ENSG00000163435	ELF3	Ets; AT hook	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000418;IPR003118;IPR013761;	1999	E74 like ETS transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3318]	3JTG	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11893733	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000163435#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000163435#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163435#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9234700	$#ENSP00000352673#ENSG00000163435#ENST00000359651#ETS#SAM_PNT$#ENSP00000356252#ENSG00000163435#ENST00000367283#ETS#SAM_PNT$#ENSP00000356253#ENSG00000163435#ENST00000367284#ETS#SAM_PNT$#ENSP00000405162#ENSG00000163435#ENST00000446188#ETS#SAM_PNT	FALSE
1140	ENSG00000059122	FLYWCH1	FLYWCH	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Several C. elegans FLYWCH domain proteins bind specific DNA sequences in Y1H and EMSA (PMID: 18794349 and PMID: 15165844).	IPR007588;IPR029279	84256	FLYWCH-type zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25404]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	None	$#ENSP00000253928#ENSG00000059122#ENST00000253928#FLYWCH#FLYWCH_N, FLYWCH_u$#ENSP00000344122#ENSG00000059122#ENST00000344592#FLYWCH#FLYWCH_u$#ENSP00000399938#ENSG00000059122#ENST00000416288#FLYWCH#FLYWCH_N, FLYWCH_u$#ENSP00000458661#ENSG00000059122#ENST00000573564#FLYWCH#FLYWCH_u$#ENSP00000458282#ENSG00000059122#ENST00000570425#FLYWCH#FLYWCH_N$#ENSP00000461566#ENSG00000059122#ENST00000571580#FLYWCH#$#ENSP00000458689#ENSG00000059122#ENST00000571983#FLYWCH#$#ENSP00000459326#ENSG00000059122#ENST00000573525#FLYWCH#FLYWCH_N$#ENSP00000459480#ENSG00000059122#ENST00000575679#FLYWCH#	FALSE
1141	ENSG00000129514	FOXA1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR013638;IPR018122;IPR018533	3169	forkhead box A1 [Source:HGNC Symbol;Acc:HGNC:5021]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2227418;11864602;15485926;15539431	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000129514#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000129514#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000129514#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8652662$#ENSG00000129514#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:16087863	$#ENSP00000250448#ENSG00000129514#ENST00000250448#Forkhead#Forkhead_N, HNF_C	FALSE
1142	ENSG00000125798	FOXA2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR013638;IPR018122;IPR018533	3170	forkhead box A2 [Source:HGNC Symbol;Acc:HGNC:5022]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16847327	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000125798#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000125798#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12124776, PMID:12911579, PMID:9931457$#ENSG00000125798#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12642491	$#ENSP00000366319#ENSG00000125798#ENST00000377115#Forkhead#Forkhead_N, HNF_C$#ENSP00000400341#ENSG00000125798#ENST00000419308#Forkhead#Forkhead_N, HNF_C	FALSE
1143	ENSG00000170608	FOXA3	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR013638;IPR018122;IPR018533	3171	forkhead box A3 [Source:HGNC Symbol;Acc:HGNC:5023]	1VTN	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000170608#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000170608#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12695546 | TAS - PMID:9369482	$#ENSP00000304004#ENSG00000170608#ENST00000302177#Forkhead#Forkhead_N, HNF_C$#ENSP00000470816#ENSG00000170608#ENST00000594297#Forkhead#Forkhead_N	FALSE
1144	ENSG00000171956	FOXB1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	27023	forkhead box B1 [Source:HGNC Symbol;Acc:HGNC:3799]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000171956#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000379369#ENSG00000171956#ENST00000396057#Forkhead#	FALSE
1145	ENSG00000204612	FOXB2	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	442425	forkhead box B2 [Source:HGNC Symbol;Acc:HGNC:23315]	None	not tested	not tested	None	None	x	Yes	No	Yes	1a2, Orthologous HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000204612#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000365898#ENSG00000204612#ENST00000376708#Forkhead#	FALSE
1146	ENSG00000054598	FOXC1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2296	forkhead box C1 [Source:HGNC Symbol;Acc:HGNC:3800]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11179011;17000708;12533514;15684392	Yes	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000054598#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000054598#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036$#ENSG00000054598#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11179011, PMID:11782474, PMID:14506133,$#ENSG00000054598#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000370256#ENSG00000054598#ENST00000380874#Forkhead#	FALSE
1147	ENSG00000176692	FOXC2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2303	forkhead box C2 [Source:HGNC Symbol;Acc:HGNC:3801]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000176692#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20956529$#ENSG00000176692#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9169153$#ENSG00000176692#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000326371#ENSG00000176692#ENST00000320354#Forkhead#	FALSE
1148	ENSG00000251493	FOXD1	Forkhead	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001766;IPR018122	2297	forkhead box D1 [Source:HGNC Symbol;Acc:HGNC:3802]	None	not tested	not tested	None	PMID: 7957066, regular GTAAACA-consensus; TFs that are in CisBP but not in Vaquerizas set	No	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066;13678594	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000251493#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000251493#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000251493#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8702877	$#ENSP00000481581#ENSG00000251493#ENST00000615637#Forkhead#	FALSE
1149	ENSG00000186564	FOXD2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2306	forkhead box D2 [Source:HGNC Symbol;Acc:HGNC:3803]	None	DBD	not tested	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12621056	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000186564#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000186564#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9403061	$#ENSP00000335493#ENSG00000186564#ENST00000334793#Forkhead#	FALSE
1150	ENSG00000187140	FOXD3	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	27022	forkhead box D3 [Source:HGNC Symbol;Acc:HGNC:3804]	2HDC	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8139574	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000187140#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:22306510$#ENSG00000187140#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000360157#ENSG00000187140#ENST00000371116#Forkhead#	FALSE
1151	ENSG00000170122	FOXD4	Forkhead	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001766;	2298	forkhead box D4 [Source:HGNC Symbol;Acc:HGNC:3805]	None	Full	Yes	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000170122#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000170122#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9325056	$#ENSP00000371940#ENSG00000170122#ENST00000382500#Forkhead#	FALSE
1152	ENSG00000184492	FOXD4L1	Forkhead	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001766;IPR018122	200350	forkhead box D4-like 1 [Source:HGNC Symbol;Acc:HGNC:18521]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000184492#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000302756#ENSG00000184492#ENST00000306507#Forkhead#	FALSE
1153	ENSG00000204828	FOXD4L2	Forkhead	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	This ENSEMBL ID has been retired.	None	None	forkhead box D4-like 2	None	Full	not tested	None	This ENSEMBL ID has been retired.	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1154	ENSG00000187559	FOXD4L3	Forkhead	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001766;IPR018122	286380	forkhead box D4-like 3 [Source:HGNC Symbol;Acc:HGNC:18523]	None	Full	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000187559#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000341961#ENSG00000187559#ENST00000342833#Forkhead#	FALSE
1155	ENSG00000184659	FOXD4L4	Forkhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001766;IPR018122	349334	forkhead box D4-like 4 [Source:HGNC Symbol;Acc:HGNC:23762]	None	Full	not tested	None	None	b	Yes	No	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000184659#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366630#ENSG00000184659#ENST00000377413#Forkhead#	FALSE
1156	ENSG00000204779	FOXD4L5	Forkhead	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001766;IPR018122	653427	forkhead box D4-like 5 [Source:HGNC Symbol;Acc:HGNC:18522]	None	not tested	not tested	None	None	x	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066;15302827	Yes	1a2, Orthologous HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000204779#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000366637#ENSG00000204779#ENST00000377420#Forkhead#	FALSE
1157	ENSG00000273514	FOXD4L6	Forkhead	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001766;IPR018122	653404	forkhead box D4-like 6 [Source:HGNC Symbol;Acc:HGNC:31986]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000273514#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000484875#ENSG00000273514#ENST00000622588#Forkhead#	FALSE
1158	ENSG00000178919	FOXE1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2304	forkhead box E1 [Source:HGNC Symbol;Acc:HGNC:3806]	None	DBD	not tested	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:15367491;15223130	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000178919#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 | IDA - PMID:24219130 | IMP -$#ENSG00000178919#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9697705	$#ENSP00000364265#ENSG00000178919#ENST00000375123#Forkhead#	FALSE
1159	ENSG00000186790	FOXE3	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2301	forkhead box E3 [Source:HGNC Symbol;Acc:HGNC:3808]	None	not tested	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a2, Orthologous HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000186790#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000186790#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10652278, PMID:25504734 | TAS - PMID:88	$#ENSP00000334472#ENSG00000186790#ENST00000335071#Forkhead#	FALSE
1160	ENSG00000103241	FOXF1	Forkhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001766;IPR018122	2294	forkhead box F1 [Source:HGNC Symbol;Acc:HGNC:3809]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8626802	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000103241#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:8626802$#ENSG00000103241#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000262426#ENSG00000103241#ENST00000262426#Forkhead#	FALSE
1161	ENSG00000137273	FOXF2	Forkhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001766;IPR018122	2295	forkhead box F2 [Source:HGNC Symbol;Acc:HGNC:3810]	None	DBD	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8626802	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000137273#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:8626802 | IMP - PMID:8626802$#ENSG00000137273#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9722567$#ENSG00000137273#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000259806#ENSG00000137273#ENST00000259806#Forkhead#	FALSE
1162	ENSG00000176165	FOXG1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2290	forkhead box G1 [Source:HGNC Symbol;Acc:HGNC:3811]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7585630;16314515;17482455	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000176165#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000339004#ENSG00000176165#ENST00000313071#Forkhead#	FALSE
1163	ENSG00000160973	FOXH1	Forkhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	Full length protein did not yield an HT-SELEX motif	IPR001766;	8928	forkhead box H1 [Source:HGNC Symbol;Acc:HGNC:3814]	None	DBD	not tested	None	PMID:25359723 ChIP-seq, PWM is not a canonical FOX-site but has AATCCACA consensus also in Jaspar ChIP-seq_JASPAR_Mathelier_2014_Direct	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI_PMIDS:9702197;9858566	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000160973#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000160973#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000160973#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17438144 | NAS - PMID:17507406$#ENSG00000160973#GO:2000824#negative regulation of androgen receptor activity#IDA - PMID:16120611	$#ENSP00000366534#ENSG00000160973#ENST00000377317#Forkhead#	FALSE
1164	ENSG00000168269	FOXI1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2299	forkhead box I1 [Source:HGNC Symbol;Acc:HGNC:3815]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9153225	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000168269#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19214237$#ENSG00000168269#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19214237	$#ENSP00000304286#ENSG00000168269#ENST00000306268#Forkhead#$#ENSP00000415483#ENSG00000168269#ENST00000449804#Forkhead#	FALSE
1165	ENSG00000186766	FOXI2	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	399823	forkhead box I2 [Source:HGNC Symbol;Acc:HGNC:32448]	None	DBD	Yes	None	None	c	Yes	No	Yes	1a2, Orthologous HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000186766#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000373572#ENSG00000186766#ENST00000388920#Forkhead#	FALSE
1166	ENSG00000214336	FOXI3	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	344167	forkhead box I3 [Source:HGNC Symbol;Acc:HGNC:35123]	None	not tested	not tested	None	PMID: 26450968 Our results suggest that Foxi3 maintains dental epithelial cells in an undifferentiated state and thereby regulates multiple stages of tooth morphogenesis	No	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000214336#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000478384#ENSG00000214336#ENST00000428390#Forkhead#	FALSE
1167	ENSG00000129654	FOXJ1	Forkhead	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001766;IPR018122	2302	forkhead box J1 [Source:HGNC Symbol;Acc:HGNC:3816]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000129654#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000129654#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000129654#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9073514$#ENSG00000129654#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000323880#ENSG00000129654#ENST00000322957#Forkhead#	FALSE
1168	ENSG00000065970	FOXJ2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	55810	forkhead box J2 [Source:HGNC Symbol;Acc:HGNC:24818]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10777590	Yes	1a1, Direct HQ evidence	Matt Weirauch	Tim Hughes	Yes	$#ENSG00000065970#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10777590	$#ENSP00000162391#ENSG00000065970#ENST00000162391#Forkhead#$#ENSP00000403411#ENSG00000065970#ENST00000428177#Forkhead#	FALSE
1169	ENSG00000198815	FOXJ3	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	22887	forkhead box J3 [Source:HGNC Symbol;Acc:HGNC:29178]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000198815#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000354620#ENSG00000198815#ENST00000361346#Forkhead#$#ENSP00000361653#ENSG00000198815#ENST00000372572#Forkhead#$#ENSP00000393408#ENSG00000198815#ENST00000445886#Forkhead#$#ENSP00000439044#ENSG00000198815#ENST00000545068#Forkhead#$#ENSP00000361652#ENSG00000198815#ENST00000372571#Forkhead#$#ENSP00000361654#ENSG00000198815#ENST00000372573#Forkhead#$#ENSP00000388099#ENSG00000198815#ENST00000422278#Forkhead#$#ENSP00000403060#ENSG00000198815#ENST00000454417#Forkhead#	FALSE
1170	ENSG00000164916	FOXK1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000253;IPR001766;IPR008984;IPR018122	221937	forkhead box K1 [Source:HGNC Symbol;Acc:HGNC:23480]	None	DBD	Yes	None	None	c	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8007964;9271401	Yes	1a1, Direct HQ evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000164916#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000328720#ENSG00000164916#ENST00000328914#Forkhead#FHA$#ENSP00000475486#ENSG00000164916#ENST00000460979#Forkhead#	FALSE
1171	ENSG00000141568	FOXK2	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000253;IPR001766;IPR008984;IPR018122	3607	forkhead box K2 [Source:HGNC Symbol;Acc:HGNC:6036]	2C6Y	DBD	not tested	None	The crystal is an interesting through-DNA homodimer	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000141568#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9065434$#ENSG00000141568#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:12402362	$#ENSP00000335677#ENSG00000141568#ENST00000335255#Forkhead#FHA$#ENSP00000461540#ENSG00000141568#ENST00000575578#Forkhead#$#ENSP00000433167#ENSG00000141568#ENST00000531030#Forkhead#$#ENSP00000432663#ENSG00000141568#ENST00000526383#Forkhead#	FALSE
1172	ENSG00000176678	FOXL1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2300	forkhead box L1 [Source:HGNC Symbol;Acc:HGNC:3817]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000176678#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000176678#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000472376#ENSG00000176678#ENST00000593625#Forkhead#$#ENSP00000326272#ENSG00000176678#ENST00000320241#Forkhead#	FALSE
1173	ENSG00000183770	FOXL2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	668	forkhead box L2 [Source:HGNC Symbol;Acc:HGNC:1092]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15059956	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000183770#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000183770#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000183770#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | NAS - PMID:11175783, PMID:1	$#ENSP00000333188#ENSG00000183770#ENST00000330315#Forkhead#	FALSE
1174	ENSG00000111206	FOXM1	Forkhead	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001766;IPR018122	2305	forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818]	3G73	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9108152;9242644	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000111206#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000342307#ENSG00000111206#ENST00000342628#Forkhead#$#ENSP00000352901#ENSG00000111206#ENST00000359843#Forkhead#$#ENSP00000354492#ENSG00000111206#ENST00000361953#Forkhead#$#ENSP00000486536#ENSG00000111206#ENST00000627656#Forkhead#$#ENSP00000442309#ENSG00000111206#ENST00000535350#Forkhead#	FALSE
1175	ENSG00000109101	FOXN1	Forkhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001766;	8456	forkhead box N1 [Source:HGNC Symbol;Acc:HGNC:12765]	None	DBD	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000109101#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000226247#ENSG00000109101#ENST00000226247#Forkhead#$#ENSP00000464645#ENSG00000109101#ENST00000579795#Forkhead#$#ENSP00000462159#ENSG00000109101#ENST00000577936#Forkhead#	FALSE
1176	ENSG00000170802	FOXN2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	3344	forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000170802#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000343633#ENSG00000170802#ENST00000340553#Forkhead#$#ENSP00000388486#ENSG00000170802#ENST00000413569#Forkhead#$#ENSP00000484534#ENSG00000170802#ENST00000616844#Forkhead#	FALSE
1177	ENSG00000053254	FOXN3	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	1112	forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000053254#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000261302#ENSG00000053254#ENST00000261302#Forkhead#$#ENSP00000343288#ENSG00000053254#ENST00000345097#Forkhead#$#ENSP00000452227#ENSG00000053254#ENST00000555353#Forkhead#$#ENSP00000452005#ENSG00000053254#ENST00000557258#Forkhead#$#ENSP00000479114#ENSG00000053254#ENST00000615335#Forkhead#$#ENSP00000452444#ENSG00000053254#ENST00000553353#Forkhead#$#ENSP00000451902#ENSG00000053254#ENST00000553904#Forkhead#$#ENSP00000452290#ENSG00000053254#ENST00000555034#Forkhead#$#ENSP00000450684#ENSG00000053254#ENST00000556916#Forkhead#$#ENSP00000450783#ENSG00000053254#ENST00000557572#Forkhead#	FALSE
1178	ENSG00000139445	FOXN4	Forkhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001766;	121643	forkhead box N4 [Source:HGNC Symbol;Acc:HGNC:21399]	None	DBD and Full	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000139445#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000299162#ENSG00000139445#ENST00000299162#Forkhead#$#ENSP00000347354#ENSG00000139445#ENST00000355216#Forkhead#$#ENSP00000474754#ENSG00000139445#ENST00000468516#Forkhead#	FALSE
1179	ENSG00000150907	FOXO1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	2308	forkhead box O1 [Source:HGNC Symbol;Acc:HGNC:3819]	3CO6	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10385407	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000150907#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000150907#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000368880#ENSG00000150907#ENST00000379561#Forkhead#FOXO-TAD, FOXO_KIX_bdg	FALSE
1180	ENSG00000118689	FOXO3	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	2309	forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821]	2UZK	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10102273	Yes	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000118689#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:20371612$#ENSG00000118689#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000118689#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14734530	$#ENSP00000339527#ENSG00000118689#ENST00000343882#Forkhead#FOXO-TAD, FOXO_KIX_bdg$#ENSP00000385824#ENSG00000118689#ENST00000406360#Forkhead#FOXO-TAD, FOXO_KIX_bdg$#ENSP00000446316#ENSG00000118689#ENST00000540898#Forkhead#FOXO-TAD, FOXO_KIX_bdg	FALSE
1181	ENSG00000184481	FOXO4	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	4303	forkhead box O4 [Source:HGNC Symbol;Acc:HGNC:7139]	3L2C	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11777915	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000184481#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000184481#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10783894	$#ENSP00000363377#ENSG00000184481#ENST00000374259#Forkhead#FOXO-TAD, FOXO_KIX_bdg$#ENSP00000342209#ENSG00000184481#ENST00000341558#Forkhead#FOXO-TAD, FOXO_KIX_bdg	FALSE
1182	ENSG00000204060	FOXO6	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	100132074	forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814]	None	DBD	Yes	None	None	x	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:12857750;15987244	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000204060#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000361672#ENSG00000204060#ENST00000372591#Forkhead#	FALSE
1183	ENSG00000114861	FOXP1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001766;	27086	forkhead box P1 [Source:HGNC Symbol;Acc:HGNC:3823]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8265594;16819554	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000114861#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000318721#ENSG00000114861#ENST00000318779#Forkhead#$#ENSP00000318902#ENSG00000114861#ENST00000318789#Forkhead#FOXP-CC$#ENSP00000419393#ENSG00000114861#ENST00000475937#Forkhead#FOXP-CC$#ENSP00000418225#ENSG00000114861#ENST00000497355#Forkhead#FOXP-CC$#ENSP00000417857#ENSG00000114861#ENST00000484350#Forkhead#FOXP-CC$#ENSP00000420736#ENSG00000114861#ENST00000491238#Forkhead#FOXP-CC$#ENSP00000418524#ENSG00000114861#ENST00000493089#Forkhead#FOXP-CC$#ENSP00000418102#ENSG00000114861#ENST00000498215#Forkhead#FOXP-CC$#ENSP00000482847#ENSG00000114861#ENST00000614176#Forkhead#FOXP-CC$#ENSP00000484963#ENSG00000114861#ENST00000472382#Forkhead#$#ENSP00000417941#ENSG00000114861#ENST00000485326#Forkhead#FOXP-CC$#ENSP00000477918#ENSG00000114861#ENST00000622151#Forkhead#	FALSE
1184	ENSG00000128573	FOXP2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	93986	forkhead box P2 [Source:HGNC Symbol;Acc:HGNC:13875]	2A07	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:11358962;14701752;11358962;14701752	Yes	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000128573#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000128573#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000128573#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18987363	$#ENSP00000265436#ENSG00000128573#ENST00000350908#Forkhead#FOXP-CC$#ENSP00000353367#ENSG00000128573#ENST00000360232#Forkhead#FOXP-CC$#ENSP00000367482#ENSG00000128573#ENST00000378237#Forkhead#CDC45, FOXP-CC$#ENSP00000375084#ENSG00000128573#ENST00000390668#Forkhead#CDC45, FOXP-CC$#ENSP00000377129#ENSG00000128573#ENST00000393489#Forkhead#CDC45, FOXP-CC$#ENSP00000386200#ENSG00000128573#ENST00000408937#Forkhead#CDC45, FOXP-CC$#ENSP00000418100#ENSG00000128573#ENST00000462331#Forkhead#$#ENSP00000385069#ENSG00000128573#ENST00000403559#Forkhead#CDC45, FOXP-CC	FALSE
1185	ENSG00000049768	FOXP3	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR007087	50943	forkhead box P3 [Source:HGNC Symbol;Acc:HGNC:6106]	3QRF	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17028180	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000049768#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000049768#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11483607 | NAS - PMID:11138001$#ENSG00000049768#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000049768#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16652169$#ENSG00000049768#GO:0032792#negative regulation of CREB transcription factor activity#IDA - PMID:16652169$#ENSG00000049768#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16873067	$#ENSP00000365380#ENSG00000049768#ENST00000376207#Forkhead#FOXP-CC$#ENSP00000428952#ENSG00000049768#ENST00000518685#Forkhead#FOXP-CC$#ENSP00000365372#ENSG00000049768#ENST00000376199#Forkhead#FOXP-CC$#ENSP00000451208#ENSG00000049768#ENST00000557224#Forkhead#FOXP-CC	FALSE
1186	ENSG00000137166	FOXP4	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	116113	forkhead box P4 [Source:HGNC Symbol;Acc:HGNC:20842]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701752	Yes	1a2, Orthologous HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000137166#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000309823#ENSG00000137166#ENST00000307972#Forkhead#FOXP-CC$#ENSP00000362148#ENSG00000137166#ENST00000373057#Forkhead#FOXP-CC$#ENSP00000362154#ENSG00000137166#ENST00000373063#Forkhead#FOXP-CC$#ENSP00000393704#ENSG00000137166#ENST00000451305#Forkhead#	FALSE
1187	ENSG00000164379	FOXQ1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	94234	forkhead box Q1 [Source:HGNC Symbol;Acc:HGNC:20951]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10896677	Yes	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000164379#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000296839#ENSG00000164379#ENST00000296839#Forkhead#	FALSE
1188	ENSG00000176302	FOXR1	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	283150	forkhead box R1 [Source:HGNC Symbol;Acc:HGNC:29980]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000176302#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000314806#ENSG00000176302#ENST00000317011#Forkhead#$#ENSP00000432358#ENSG00000176302#ENST00000533282#Forkhead#	FALSE
1189	ENSG00000189299	FOXR2	Forkhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;	139628	forkhead box R2 [Source:HGNC Symbol;Acc:HGNC:30469]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000189299#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000427329#ENSG00000189299#ENST00000339140#Forkhead#	FALSE
1190	ENSG00000179772	FOXS1	Forkhead	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001766;IPR018122	2307	forkhead box S1 [Source:HGNC Symbol;Acc:HGNC:3735]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a2, Orthologous HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000179772#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000179772#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9325056$#ENSG00000179772#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000365145#ENSG00000179772#ENST00000375978#Forkhead#	FALSE
1191	ENSG00000072121	ZFYVE26	FYVE-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	FYVE zinc fingers are unlikely to bind DNA	IPR000306;IPR011011;IPR017455;	23503	zinc finger FYVE-type containing 26 [Source:HGNC Symbol;Acc:HGNC:20761]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000251119#ENSG00000072121#ENST00000347230#Other#FYVE, TPR_2$#ENSP00000450603#ENSG00000072121#ENST00000555452#Other#FYVE, TPR_14, TPR_2$#ENSP00000452142#ENSG00000072121#ENST00000557306#Other#	FALSE
1192	ENSG00000102145	GATA1	GATA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000679;IPR016374	2623	GATA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4170]	1GAT	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1650452;2725678	Yes	1a1, Direct HQ evidence	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000102145#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000102145#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15920471$#ENSG00000102145#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000102145#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:2467208	$#ENSP00000365858#ENSG00000102145#ENST00000376670#GATA#$#ENSP00000365853#ENSG00000102145#ENST00000376665#GATA#	FALSE
1193	ENSG00000179348	GATA2	GATA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000679;IPR016374	2624	GATA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4171]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9565596;14512418	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000179348#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000179348#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000179348#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15016828, PMID:20206639	$#ENSP00000345681#ENSG00000179348#ENST00000341105#GATA#$#ENSP00000400259#ENSG00000179348#ENST00000430265#GATA#$#ENSP00000417074#ENSG00000179348#ENST00000487848#GATA#$#ENSP00000419532#ENSG00000179348#ENST00000498200#GATA#$#ENSP00000418132#ENSG00000179348#ENST00000492608#GATA#	FALSE
1194	ENSG00000107485	GATA3	GATA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000679;IPR016374	2625	GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172]	3DFV	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8332492	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000107485#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000107485#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:19674970$#ENSG00000107485#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000107485#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2050118, PMID:8088776	$#ENSP00000341619#ENSG00000107485#ENST00000346208#GATA#$#ENSP00000368632#ENSG00000107485#ENST00000379328#GATA#	FALSE
1195	ENSG00000136574	GATA4	GATA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000679;IPR008013;IPR016375;	2626	GATA binding protein 4 [Source:HGNC Symbol;Acc:HGNC:4173]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8455608	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000136574#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000136574#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9312027	$#ENSP00000435712#ENSG00000136574#ENST00000532059#GATA#GATA-N$#ENSP00000473671#ENSG00000136574#ENST00000532977#GATA#GATA-N$#ENSP00000473598#ENSG00000136574#ENST00000526974#GATA#GATA-N$#ENSP00000432278#ENSG00000136574#ENST00000528027#GATA#GATA-N$#ENSP00000435043#ENSG00000136574#ENST00000528712#GATA#	FALSE
1196	ENSG00000130700	GATA5	GATA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000679;IPR008013;IPR016375;	140628	GATA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15802]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10212267;11408257	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000130700#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000130700#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:14986113$#ENSG00000130700#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000252997#ENSG00000130700#ENST00000252997#GATA#GATA-N	FALSE
1197	ENSG00000141448	GATA6	GATA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000679;IPR008013	2627	GATA binding protein 6 [Source:HGNC Symbol;Acc:HGNC:4174]	None	DBD	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14988427	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000141448#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IMP - PMID:21127043$#ENSG00000141448#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000141448#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19666519$#ENSG00000141448#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000269216#ENSG00000141448#ENST00000269216#GATA#GATA-N$#ENSP00000462313#ENSG00000141448#ENST00000581694#GATA#GATA-N	FALSE
1198	ENSG00000157259	GATAD1	GATA	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The GATA domain is truncated (see alignment)	IPR000679;	57798	GATA zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29941]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000157259#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000287957#ENSG00000157259#ENST00000287957#GATA#	FALSE
1199	ENSG00000167491	GATAD2A	GATA	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too.	IPR000679;	54815	GATA zinc finger domain containing 2A [Source:HGNC Symbol;Acc:HGNC:29989]	None	not tested	not tested	None	PMID:12183469 shows that this protein interacts strongly with MBD2 and MBD3 in silencing	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000167491#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000351552#ENSG00000167491#ENST00000358713#GATA#P66_CC$#ENSP00000384899#ENSG00000167491#ENST00000404158#GATA#P66_CC$#ENSP00000403703#ENSG00000167491#ENST00000417582#GATA#P66_CC$#ENSP00000404212#ENSG00000167491#ENST00000457895#GATA#P66_CC$#ENSP00000477171#ENSG00000167491#ENST00000494516#GATA#$#ENSP00000414252#ENSG00000167491#ENST00000429242#GATA#	FALSE
1200	ENSG00000143614	GATAD2B	GATA	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has the full GATA domain, and JPRED4 thinks the secondary structure is preserved. The GATA domain is not sufficiently well studied to declare that specific amino acids are absolutely required in order to bind DNA. Many unusual GATA domain proteins across eukaryotes bind DNA, making it reasonable to project that this one does, too.	IPR000679;	57459	GATA zinc finger domain containing 2B [Source:HGNC Symbol;Acc:HGNC:30778]	None	not tested	Yes	None	PMID:12183469 shows that this protein interacts strongly with MBD2 and MBD3 in silencing	x	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:12183469;16415179	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000143614#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000357644#ENSG00000143614#ENST00000368655#GATA#P66_CC$#ENSP00000489566#ENSG00000143614#ENST00000634791#GATA#$#ENSP00000490635#ENSG00000143614#ENST00000637331#GATA#$#ENSP00000490724#ENSG00000143614#ENST00000637918#GATA#	FALSE
1201	ENSG00000104447	TRPS1	GATA	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000679;IPR007087;IPR015880;	7227	transcriptional repressor GATA binding 1 [Source:HGNC Symbol;Acc:HGNC:12340]	None	Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:10615131;11112658;12761050	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000104447#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000104447#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10615131	$#ENSP00000220888#ENSG00000104447#ENST00000220888#GATA#zf-H2C2_5$#ENSP00000379065#ENSG00000104447#ENST00000395715#GATA#zf-H2C2_5$#ENSP00000429174#ENSG00000104447#ENST00000519674#GATA#Actin_micro, zf-H2C2_5$#ENSP00000405028#ENSG00000104447#ENST00000422939#GATA#$#ENSP00000428121#ENSG00000104447#ENST00000518018#GATA#$#ENSP00000428680#ENSG00000104447#ENST00000520276#GATA#zf-H2C2_5$#ENSP00000379063#ENSG00000104447#ENST00000395713#GATA#$#ENSP00000430383#ENSG00000104447#ENST00000519815#GATA#	FALSE
1202	ENSG00000220201	ZGLP1	GATA	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000679;	100125288	zinc finger, GATA-like protein 1 [Source:HGNC Symbol;Acc:HGNC:37245]	None	DBD	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000220201#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000384434#ENSG00000220201#ENST00000403903#GATA#$#ENSP00000385403#ENSG00000220201#ENST00000403352#GATA#	FALSE
1203	ENSG00000137270	GCM1	GCM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003902;	8521	glial cells missing homolog 1 [Source:HGNC Symbol;Acc:HGNC:4197]	1ODH	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12682016;15385555	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000137270#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:23867755$#ENSG00000137270#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15385555$#ENSG00000137270#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15385555	$#ENSP00000259803#ENSG00000137270#ENST00000259803#GCM#	FALSE
1204	ENSG00000124827	GCM2	GCM	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003902;	9247	glial cells missing homolog 2 [Source:HGNC Symbol;Acc:HGNC:4198]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10671510	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000124827#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000368805#ENSG00000124827#ENST00000379491#GCM#	FALSE
1205	ENSG00000134317	GRHL1	Grainyhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007604;	29841	grainyhead like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:17923]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12175488	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000134317#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12175488	$#ENSP00000324693#ENSG00000134317#ENST00000324907#CP2#$#ENSP00000384209#ENSG00000134317#ENST00000405379#CP2#$#ENSP00000419831#ENSG00000134317#ENST00000480736#CP2#	FALSE
1206	ENSG00000083307	GRHL2	Grainyhead	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR007604;	79977	grainyhead like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2799]	None	DBD and Full	Yes	None	PMID: 25758223, binds similar sites as GRHL1 in ChIP-seq	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000083307#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23814079$#ENSG00000083307#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000251808#ENSG00000083307#ENST00000251808#CP2#$#ENSP00000379260#ENSG00000083307#ENST00000395927#CP2#$#ENSP00000430473#ENSG00000083307#ENST00000521085#CP2#	FALSE
1207	ENSG00000158055	GRHL3	Grainyhead	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds the same AACCGGTT consensus as the paralog GRHL1 based on SELEX (PMID: 21081122).	IPR007604;	57822	grainyhead like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:25839]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12549979;15831758	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000158055#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23685552	$#ENSP00000236255#ENSG00000158055#ENST00000236255#CP2#$#ENSP00000348333#ENSG00000158055#ENST00000356046#CP2#$#ENSP00000354943#ENSG00000158055#ENST00000361548#CP2#$#ENSP00000288955#ENSG00000158055#ENST00000350501#CP2#	FALSE
1208	ENSG00000135457	TFCP2	Grainyhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007604;IPR013761	7024	transcription factor CP2 [Source:HGNC Symbol;Acc:HGNC:11748]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15232220	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000135457#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8157699	$#ENSP00000257915#ENSG00000135457#ENST00000257915#CP2#$#ENSP00000449280#ENSG00000135457#ENST00000548108#CP2#$#ENSP00000447991#ENSG00000135457#ENST00000548115#CP2#$#ENSP00000449742#ENSG00000135457#ENST00000549867#CP2#	FALSE
1209	ENSG00000115112	TFCP2L1	Grainyhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007604;IPR013761	29842	transcription factor CP2-like 1 [Source:HGNC Symbol;Acc:HGNC:17925]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000115112#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10644752	$#ENSP00000263707#ENSG00000115112#ENST00000263707#CP2#	FALSE
1210	ENSG00000153560	UBP1	Grainyhead	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007604;IPR013761	7342	upstream binding protein 1 (LBP-1a) [Source:HGNC Symbol;Acc:HGNC:12507]	None	DBD	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15988015	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000153560#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8114710	$#ENSP00000283629#ENSG00000153560#ENST00000283629#CP2#$#ENSP00000283628#ENSG00000153560#ENST00000283628#CP2#$#ENSP00000395558#ENSG00000153560#ENST00000447368#CP2#$#ENSP00000401614#ENSG00000153560#ENST00000456378#CP2#	FALSE
1211	ENSG00000263001	GTF2I	GTF2I-like	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	(PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious.	IPR004212;IPR016659	2969	general transcription factor IIi [Source:HGNC Symbol;Acc:HGNC:4659]	None	not tested	not tested	None	None	No	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8662630;17052463	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Jussi Taipale	No	$#ENSG00000263001#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000263001#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9334314	$#ENSP00000404240#ENSG00000263001#ENST00000443166#GTF2I#$#ENSP00000460070#ENSG00000263001#ENST00000573035#GTF2I#$#ENSP00000484526#ENSG00000263001#ENST00000614986#GTF2I#$#ENSP00000477837#ENSG00000263001#ENST00000620879#GTF2I#$#ENSP00000482476#ENSG00000263001#ENST00000621734#GTF2I#	FALSE
1212	ENSG00000006704	GTF2IRD1	GTF2I-like	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	(PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious. V$BEN_02 motif has partial similarity to a shift-experiment sequence (PMID:14645227), which shows DNA-binding and evidence of transcriptional regulation by knockdown experiments	IPR004212;IPR016659	9569	GTF2I repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:4661]	None	DBD and Full	not tested	None	None	No	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14645227	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Arttu Jolma	No	$#ENSG00000006704#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000006704#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10575229$#ENSG00000006704#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#NAS - PMID:9774679	$#ENSP00000265755#ENSG00000006704#ENST00000265755#GTF2I#$#ENSP00000408477#ENSG00000006704#ENST00000424337#GTF2I#$#ENSP00000397566#ENSG00000006704#ENST00000455841#GTF2I#$#ENSP00000418383#ENSG00000006704#ENST00000476977#GTF2I#$#ENSP00000417909#ENSG00000006704#ENST00000470715#GTF2I#	FALSE
1213	ENSG00000196275	GTF2IRD2	GTF2I-like	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	(PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically.	IPR004212;IPR012337	84163	GTF2I repeat domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30775]	None	not tested	Yes	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000406723#ENSG00000196275#ENST00000451013#GTF2I#DUF4371, Med25_NR-box$#ENSP00000481017#ENSG00000196275#ENST00000614386#GTF2I#$#ENSP00000486581#ENSG00000196275#ENST00000625377#GTF2I#	FALSE
1214	ENSG00000174428	GTF2IRD2B	GTF2I-like	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	(PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically.	IPR004212;IPR012337	389524	GTF2I repeat domain containing 2B [Source:HGNC Symbol;Acc:HGNC:33125]	None	Full	not tested	None	None	x	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000174428#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000480524#ENSG00000174428#ENST00000472837#GTF2I#DUF4371, Med25_NR-box$#ENSP00000481706#ENSG00000174428#ENST00000614064#GTF2I#$#ENSP00000480037#ENSG00000174428#ENST00000619142#GTF2I#$#ENSP00000486360#ENSG00000174428#ENST00000629105#GTF2I#	FALSE
1215	ENSG00000258724	AC105001.2	HMG/Sox	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Unlikely to be sequence specific TF - it has a deletion inside the SOX-domain removing several residues that contact DNA based on the structure of paralog SOX17.	IPR000467;IPR009071;IPR021934	None	CTD-2135J3.4	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000451145#ENSG00000258724#ENST00000554914#HMG#G-patch, G-patch_2, Sox17_18_mid	FALSE
1216	ENSG00000114439	BBX	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR019102	56987	BBX, HMG-box containing [Source:HGNC Symbol;Acc:HGNC:14422]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	None	$#ENSP00000319974#ENSG00000114439#ENST00000325805#HMG#DUF2028$#ENSP00000408358#ENSG00000114439#ENST00000415149#HMG#DUF2028$#ENSP00000403860#ENSG00000114439#ENST00000416476#HMG#DUF2028$#ENSP00000400543#ENSG00000114439#ENST00000456817#HMG#	FALSE
1217	ENSG00000007080	CCDC124	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Based on the alignment, it lacks a proper HMG domain. Evidence it binds RNA (PMID: 22658674).	IPR010422;	115098	coiled-coil domain containing 124 [Source:HGNC Symbol;Acc:HGNC:25171]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000471455#ENSG00000007080#ENST00000597436#HMG#$#ENSP00000408730#ENSG00000007080#ENST00000445755#HMG#$#ENSP00000472520#ENSG00000007080#ENST00000596123#HMG#	FALSE
1218	ENSG00000170004	CHD3	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	No evidence for sequence-specific DNA-binding in the literature; and contains only a partial match to an HMG box with no similarity to DBDs of other CHD family proteins	IPR000330;IPR000953;IPR001650;IPR001965;IPR002464;IPR009071;IPR009462;IPR009463;IPR011011;IPR012957;IPR012958;	1107	chromodomain helicase DNA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:1918]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000332628#ENSG00000170004#ENST00000330494#HMG#CHDCT2, Chromo, DEAD, DUF1086, DUF1087, HDA2-3, He$#ENSP00000350907#ENSG00000170004#ENST00000358181#HMG#CHDCT2, Chromo, DEAD, DUF1086, DUF1087, HDA2-3, He$#ENSP00000369716#ENSG00000170004#ENST00000380358#HMG#CHDCT2, Chromo, DEAD, DUF1086, DUF1087, HDA2-3, He$#ENSP00000411959#ENSG00000170004#ENST00000449744#HMG#CHDCT2$#ENSP00000458861#ENSG00000170004#ENST00000571249#HMG#$#ENSP00000459321#ENSG00000170004#ENST00000573936#HMG#CHDCT2	FALSE
1219	ENSG00000111642	CHD4	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	CHD4 is likely not a sequence-specific DNA-binding protein despite having a partial match to an HMG box. This protein binds to the DNA backbone, but binds poly(ADP-ribose) with higher affinity (PMID: 26565020).	IPR000330;IPR000953;IPR001650;IPR001965;IPR002464;IPR009462;IPR009463;IPR011011;IPR012957;IPR012958;IPR014001;	1108	chromodomain helicase DNA binding protein 4 [Source:HGNC Symbol;Acc:HGNC:1919]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000349508#ENSG00000111642#ENST00000357008#HMG#CHDCT2, Chromo, DUF1086, DUF1087, HDA2-3, Helicase$#ENSP00000437506#ENSG00000111642#ENST00000545942#HMG#CHDNT$#ENSP00000440392#ENSG00000111642#ENST00000544484#HMG#CHDCT2, Chromo, DUF1086, DUF1087, HDA2-3, Helicase$#ENSP00000444614#ENSG00000111642#ENST00000545584#HMG#	FALSE
1220	ENSG00000079432	CIC	HMG/Sox	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR009071;	23152	capicua transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:14214]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:16717057	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000458663#ENSG00000079432#ENST00000575354#HMG#$#ENSP00000458543#ENSG00000079432#ENST00000573349#HMG#$#ENSP00000459011#ENSG00000079432#ENST00000576505#HMG#	FALSE
1221	ENSG00000105856	HBP1	HMG/Sox	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR003652;IPR009071;IPR013723;	26959	HMG-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:23200]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	None	$#ENSP00000222574#ENSG00000105856#ENST00000222574#HMG#AXH$#ENSP00000420500#ENSG00000105856#ENST00000468410#HMG#AXH$#ENSP00000417927#ENSG00000105856#ENST00000479011#HMG#$#ENSP00000418738#ENSG00000105856#ENST00000485846#HMG#AXH$#ENSP00000417631#ENSG00000105856#ENST00000497535#HMG#$#ENSP00000418017#ENSG00000105856#ENST00000498408#HMG#AXH$#ENSP00000475809#ENSG00000105856#ENST00000607681#HMG#	FALSE
1222	ENSG00000140382	HMG20A	HMG/Sox	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Similar to HMG20B, which has an inferred motif from mouse.	IPR009071;	10363	high mobility group 20A [Source:HGNC Symbol;Acc:HGNC:5001]	None	not tested	not tested	None	None	x	Yes	No	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000140382#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10773667	$#ENSP00000336856#ENSG00000140382#ENST00000336216#HMG#DUF4763$#ENSP00000371133#ENSG00000140382#ENST00000381714#HMG#DUF4763$#ENSP00000452847#ENSG00000140382#ENST00000558845#HMG#DUF4763, IncA, Trans_reg_C$#ENSP00000452665#ENSG00000140382#ENST00000558176#HMG#	FALSE
1223	ENSG00000064961	HMG20B	HMG/Sox	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;	10362	high mobility group 20B [Source:HGNC Symbol;Acc:HGNC:5002]	None	not tested	not tested	None	None	x	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	None	$#ENSP00000328269#ENSG00000064961#ENST00000333651#HMG#$#ENSP00000402877#ENSG00000064961#ENST00000453933#HMG#$#ENSP00000410924#ENSG00000064961#ENST00000416526#HMG#$#ENSP00000465293#ENSG00000064961#ENST00000585900#HMG#IncA	FALSE
1224	ENSG00000189403	HMGB1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB1/2 are non-sequence-specific binding proteins (PMID: 11497996).	IPR009071;IPR017967	3146	high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983]	1CKT	not tested	not tested	None	The structure is with interstrand crosslinked DNA	x	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Jussi Taipale	No	$#ENSG00000189403#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19223331	$#ENSP00000345347#ENSG00000189403#ENST00000341423#HMG#$#ENSP00000382412#ENSG00000189403#ENST00000399489#HMG#$#ENSP00000343040#ENSG00000189403#ENST00000339872#HMG#$#ENSP00000382417#ENSG00000189403#ENST00000399494#HMG#$#ENSP00000384678#ENSG00000189403#ENST00000405805#HMG#$#ENSP00000369904#ENSG00000189403#ENST00000326004#HMG#	FALSE
1225	ENSG00000164104	HMGB2	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB1/2 are non-sequence-specific binding proteins (PMID: 11497996). HMGB2 is well-known to facilitate DNA-bending and interact with sequence-specific TFs and transcriptional co-factors.	IPR009071;IPR017967	3148	high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000]	None	not tested	not tested	None	None	x	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:9888798;11748232;12517784	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000164104#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19223331	$#ENSP00000296503#ENSG00000164104#ENST00000296503#HMG#$#ENSP00000404912#ENSG00000164104#ENST00000438704#HMG#$#ENSP00000393448#ENSG00000164104#ENST00000446922#HMG#$#ENSP00000423001#ENSG00000164104#ENST00000506267#HMG#	FALSE
1226	ENSG00000029993	HMGB3	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Similar to HMGB1/2, which bind DNA with low specificity	IPR009071;IPR017967	3149	high mobility group box 3 [Source:HGNC Symbol;Acc:HGNC:5004]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	No	None	$#ENSP00000359393#ENSG00000029993#ENST00000325307#HMG#$#ENSP00000417027#ENSG00000029993#ENST00000430118#HMG#$#ENSP00000442758#ENSG00000029993#ENST00000448905#HMG#$#ENSP00000405601#ENSG00000029993#ENST00000455596#HMG#$#ENSP00000410354#ENSG00000029993#ENST00000419110#HMG#	FALSE
1227	ENSG00000176256	HMGB4	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Similar to HMGB1/2, which bind DNA with low specificity. Yet, it can also bind with 4.35nM affinity to DNA containing an intra-strand crosslink made by cis-platin (PMID: 22901013).	IPR009071;	127540	high mobility group box 4 [Source:HGNC Symbol;Acc:HGNC:24954]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000429214#ENSG00000176256#ENST00000519684#HMG#$#ENSP00000430919#ENSG00000176256#ENST00000522796#HMG#	FALSE
1228	ENSG00000205581	HMGN1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs.	IPR000079	3150	high mobility group nucleosome binding domain 1 [Source:HGNC Symbol;Acc:HGNC:4984]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:8524231;16382150	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	None	$##ENSG00000205581##Other#	FALSE
1229	ENSG00000118418	HMGN3	HMG/Sox	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR000079	9324	high mobility group nucleosomal binding domain 3 [Source:HGNC Symbol;Acc:HGNC:12312]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:7776974;11356838;15082770	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$##ENSG00000118418##Other#	FALSE
1230	ENSG00000113716	HMGXB3	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs.	IPR009071;	22993	HMG-box containing 3 [Source:HGNC Symbol;Acc:HGNC:28982]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Tim Hughes	Yimeng Yin	Yes	None	$#ENSP00000421917#ENSG00000113716#ENST00000502717#HMG#$#ENSP00000422231#ENSG00000113716#ENST00000503427#HMG#$#ENSP00000479027#ENSG00000113716#ENST00000613459#HMG#	FALSE
1231	ENSG00000100281	HMGXB4	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs.	IPR009071;IPR025228	10042	HMG-box containing 4 [Source:HGNC Symbol;Acc:HGNC:5003]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000415500#ENSG00000100281#ENST00000455359#HMG#DUF4171$#ENSP00000401658#ENSG00000100281#ENST00000420166#HMG#DUF4171$#ENSP00000216106#ENSG00000100281#ENST00000216106#HMG#DUF4171	FALSE
1232	ENSG00000055609	KMT2C	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	Based on the alignment, it is quite different from all other HMG proteins. It is borderline to say that it is a HMG at all.	IPR000637;IPR001214;IPR001594;IPR001841;IPR001965;IPR003616;IPR003888;IPR003889;IPR009071;IPR011011;IPR019787;	58508	lysine methyltransferase 2C [Source:HGNC Symbol;Acc:HGNC:13726]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Matt Weirauch	No	None	$#ENSP00000262189#ENSG00000055609#ENST00000262189#HMG#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000347325#ENSG00000055609#ENST00000355193#HMG#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000353218#ENSG00000055609#ENST00000360104#HMG#FYRC, FYRN, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000454058#ENSG00000055609#ENST00000558665#HMG#	FALSE
1233	ENSG00000167548	KMT2D	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Based on alignment it is quite different from all other HMG proteins, borderline to say if it is a HMG at all. Crystal structure has an aminoacid sequence that doesnt match to the protein it claims to be	IPR001214;IPR001841;IPR001965;IPR003616;IPR003888;IPR003889;IPR009071;IPR011011;IPR019787;	8085	lysine methyltransferase 2D [Source:HGNC Symbol;Acc:HGNC:7133]	4PZI	not tested	not tested	None	Crystal structure is with a CpG containing DNA	c	Yes	No	No	3a, decent circumstantial evidence for its role as	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000435714#ENSG00000167548#ENST00000526209#HMG#SET$#ENSP00000301067#ENSG00000167548#ENST00000301067#HMG#FYRC, FYRN, PHD, SET, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000449455#ENSG00000167548#ENST00000547610#HMG#	FALSE
1234	ENSG00000138795	LEF1	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR013558	51176	lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551]	2LEF	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:10958684;11696550;14579381	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000138795#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000138795#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:23001182$#ENSG00000138795#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11751639$#ENSG00000138795#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000265165#ENSG00000138795#ENST00000265165#HMG#CTNNB1_binding$#ENSP00000369284#ENSG00000138795#ENST00000379951#HMG#CTNNB1_binding$#ENSP00000406176#ENSG00000138795#ENST00000438313#HMG#CTNNB1_binding$#ENSP00000422840#ENSG00000138795#ENST00000510624#HMG#CTNNB1_binding$#ENSP00000427365#ENSG00000138795#ENST00000512172#HMG#CTNNB1_binding$#ENSP00000422801#ENSG00000138795#ENST00000515500#HMG#CTNNB1_binding	FALSE
1235	ENSG00000143194	MAEL	HMG/Sox	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Orthologous protein from mouse binds RNA (PMID: 25807393)	IPR009071;IPR024970	84944	maelstrom spermatogenic transposon silencer [Source:HGNC Symbol;Acc:HGNC:25929]	None	DBD	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000356844#ENSG00000143194#ENST00000367870#HMG#HMG_box_2, Maelstrom$#ENSP00000356846#ENSG00000143194#ENST00000367872#HMG#Maelstrom$#ENSP00000482771#ENSG00000143194#ENST00000622874#HMG#Maelstrom$#ENSP00000402143#ENSG00000143194#ENST00000447624#HMG#HMG_box_2, Maelstrom	FALSE
1236	ENSG00000109685	NSD2	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Likely affects transcription by histone modification (not specific DNA-binding).	IPR000313;IPR001214;IPR001841;IPR001965;IPR003616;IPR006560;IPR009071;IPR011011;IPR019786;IPR019787	7468	Wolf-Hirschhorn syndrome candidate 1 [Source:HGNC Symbol;Acc:HGNC:12766]	None	DBD	not tested	None	Its a histone methyltransferase, not likely to have any sequence specificity	a	Yes	No	No	3a, decent circumstantial evidence for its role as	Laura Campitelli	Yimeng Yin	Yes	None	$#ENSP00000372344#ENSG00000109685#ENST00000382888#HMG#PHD, PWWP, SET$#ENSP00000372348#ENSG00000109685#ENST00000382892#HMG#PHD, PWWP, SET, zf-HC5HC2H$#ENSP00000372351#ENSG00000109685#ENST00000382895#HMG#PHD, PWWP, SET, zf-HC5HC2H$#ENSP00000381311#ENSG00000109685#ENST00000398261#HMG#PWWP$#ENSP00000399251#ENSG00000109685#ENST00000420906#HMG#PWWP$#ENSP00000416725#ENSG00000109685#ENST00000436793#HMG#PWWP$#ENSP00000425761#ENSG00000109685#ENST00000503128#HMG#PWWP$#ENSP00000423972#ENSG00000109685#ENST00000508803#HMG#PHD, PWWP, SET, zf-HC5HC2H$#ENSP00000421681#ENSG00000109685#ENST00000514045#HMG#PWWP$#ENSP00000422878#ENSG00000109685#ENST00000509115#HMG#PWWP$#ENSP00000425094#ENSG00000109685#ENST00000514329#HMG#PHD, PHD_2, PWWP$#ENSP00000427434#ENSG00000109685#ENST00000515806#HMG#	FALSE
1237	ENSG00000163939	PBRM1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	(PMID: 23867514) shows it may bind nucleosomal DNA.	IPR001025;IPR001487;IPR009071;IPR018359	55193	polybromo 1 [Source:HGNC Symbol;Acc:HGNC:30064]	None	Full	not tested	None	None	x	Yes	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:11078522;15601824	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000296302#ENSG00000163939#ENST00000296302#HMG#BAH, Bromodomain$#ENSP00000338302#ENSG00000163939#ENST00000337303#HMG#BAH, Bromodomain$#ENSP00000349213#ENSG00000163939#ENST00000356770#HMG#BAH, Bromodomain$#ENSP00000378307#ENSG00000163939#ENST00000394830#HMG#BAH, Bromodomain$#ENSP00000386593#ENSG00000163939#ENST00000409057#HMG#BAH, Bromodomain$#ENSP00000386643#ENSG00000163939#ENST00000409114#HMG#BAH, Bromodomain$#ENSP00000386601#ENSG00000163939#ENST00000409767#HMG#BAH, Bromodomain$#ENSP00000386529#ENSG00000163939#ENST00000410007#HMG#BAH, Bromodomain$#ENSP00000397662#ENSG00000163939#ENST00000446103#HMG#BAH, Bromodomain$#ENSP00000389390#ENSG00000163939#ENST00000420148#HMG#Bromodomain$#ENSP00000412401#ENSG00000163939#ENST00000449505#HMG#Bromodomain$#ENSP00000411895#ENSG00000163939#ENST00000458294#HMG#	FALSE
1238	ENSG00000064933	PMS1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs.	IPR002099;IPR003594;IPR009071;IPR013507;IPR014762;IPR020568	5378	PMS1 homolog 1, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9121]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Tim Hughes	Pratyush Das	No	None	$#ENSP00000363959#ENSG00000064933#ENST00000374826#HMG#HATPase_c, HATPase_c_3$#ENSP00000387169#ENSG00000064933#ENST00000409593#HMG#DNA_mis_repair$#ENSP00000406490#ENSG00000064933#ENST00000441310#HMG#DNA_mis_repair, HATPase_c, HATPase_c_3$#ENSP00000386623#ENSG00000064933#ENST00000409985#HMG#HATPase_c, HATPase_c_3$#ENSP00000398378#ENSG00000064933#ENST00000432292#HMG#DNA_mis_repair$#ENSP00000401064#ENSG00000064933#ENST00000447232#HMG#DNA_mis_repair, HATPase_c, HATPase_c_3$#ENSP00000485312#ENSG00000064933#ENST00000624204#HMG#DNA_mis_repair$#ENSP00000391136#ENSG00000064933#ENST00000420421#HMG#HATPase_c, HATPase_c_3$#ENSP00000410082#ENSG00000064933#ENST00000424766#HMG#HATPase_c, HATPase_c_3	FALSE
1239	ENSG00000073584	SMARCE1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	In the alignment, it clusters with other HMG proteins that have not yielded motifs.  Contributes to SWI/SNF DNA-binding (PMID: 9435219).	IPR009071;IPR009395	6605	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [S	None	not tested	not tested	None	None	x	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:12145209;15743818	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000323967#ENSG00000073584#ENST00000348513#HMG#GCN5L1$#ENSP00000367039#ENSG00000073584#ENST00000377808#HMG#GCN5L1$#ENSP00000411607#ENSG00000073584#ENST00000400122#HMG#GCN5L1$#ENSP00000463405#ENSG00000073584#ENST00000474246#HMG#$#ENSP00000464511#ENSG00000073584#ENST00000578044#HMG#GCN5L1$#ENSP00000462475#ENSG00000073584#ENST00000580419#HMG#GCN5L1$#ENSP00000445370#ENSG00000073584#ENST00000431889#HMG#GCN5L1$#ENSP00000466608#ENSG00000073584#ENST00000264640#HMG#GCN5L1$#ENSP00000392958#ENSG00000073584#ENST00000447024#HMG#GCN5L1	FALSE
1240	ENSG00000182968	SOX1	HMG/Sox	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR009071;IPR022097	6656	SRY-box 1 [Source:HGNC Symbol;Acc:HGNC:11189]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9512512;11943779	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000182968#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000182968#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9337405	$#ENSP00000330218#ENSG00000182968#ENST00000330949#HMG#SOXp	FALSE
1241	ENSG00000100146	SOX10	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR022151	6663	SRY-box 10 [Source:HGNC Symbol;Acc:HGNC:11190]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15523643	No	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	$#ENSG00000100146#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000354130#ENSG00000100146#ENST00000360880#HMG#Sox_N$#ENSP00000380093#ENSG00000100146#ENST00000396884#HMG#Sox_N$#ENSP00000399777#ENSG00000100146#ENST00000446929#HMG#$#ENSP00000414853#ENSG00000100146#ENST00000427770#HMG#Sox_N	FALSE
1242	ENSG00000176887	SOX11	HMG/Sox	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR009071;	6664	SRY-box 11 [Source:HGNC Symbol;Acc:HGNC:11191]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15183730	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000176887#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000176887#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000322568#ENSG00000176887#ENST00000322002#HMG#	FALSE
1243	ENSG00000177732	SOX12	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;	6666	SRY-box 12 [Source:HGNC Symbol;Acc:HGNC:11198]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000177732#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024	$#ENSP00000347646#ENSG00000177732#ENST00000342665#HMG#	FALSE
1244	ENSG00000143842	SOX13	HMG/Sox	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR009071;	9580	SRY-box 13 [Source:HGNC Symbol;Acc:HGNC:11192]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate__DNA Binding_PMIDS:9421502	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000143842#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10198172	$#ENSP00000356172#ENSG00000143842#ENST00000367204#HMG#$#ENSP00000478239#ENSG00000143842#ENST00000618875#HMG#$#ENSP00000433595#ENSG00000143842#ENST00000525442#HMG#$#ENSP00000436297#ENSG00000143842#ENST00000528591#HMG#	FALSE
1245	ENSG00000168875	SOX14	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR022097	8403	SRY-box 14 [Source:HGNC Symbol;Acc:HGNC:11193]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:10798354	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000168875#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000305343#ENSG00000168875#ENST00000306087#HMG#SOXp	FALSE
1246	ENSG00000129194	SOX15	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;	6665	SRY-box 15 [Source:HGNC Symbol;Acc:HGNC:11196]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10821863	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000129194#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019$#ENSG00000129194#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8332506	$#ENSP00000355354#ENSG00000129194#ENST00000250055#HMG#$#ENSP00000439311#ENSG00000129194#ENST00000538513#HMG#$#ENSP00000458286#ENSG00000129194#ENST00000570788#HMG#	FALSE
1247	ENSG00000164736	SOX17	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR021934	64321	SRY-box 17 [Source:HGNC Symbol;Acc:HGNC:18122]	3F27	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15163629;15220343;15220343	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000164736#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000164736#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000297316#ENSG00000164736#ENST00000297316#HMG#Sox17_18_mid	FALSE
1248	ENSG00000203883	SOX18	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR021934	54345	SRY-box 18 [Source:HGNC Symbol;Acc:HGNC:11194]	4Y60	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12446692	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000203883#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22292085	$#ENSP00000341815#ENSG00000203883#ENST00000340356#HMG#Sox17_18_mid	FALSE
1249	ENSG00000181449	SOX2	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR022097	6657	SRY-box 2 [Source:HGNC Symbol;Acc:HGNC:11195]	1GT0	DBD and Full	not tested	None	Structure is POU2F1 SOX2 heterodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15860457	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000181449#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000181449#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16153702, PMID:18027866 | NAS - PMID:78	$#ENSP00000323588#ENSG00000181449#ENST00000325404#HMG#SOXp	FALSE
1250	ENSG00000125285	SOX21	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR022097	11166	SRY-box 21 [Source:HGNC Symbol;Acc:HGNC:11197]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12446692	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000125285#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#NAS - PMID:10441749$#ENSG00000125285#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000366144#ENSG00000125285#ENST00000376945#HMG#SOXp	FALSE
1251	ENSG00000134595	SOX3	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR022097	6658	SRY-box 3 [Source:HGNC Symbol;Acc:HGNC:11199]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11875113;12710953	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000134595#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000359567#ENSG00000134595#ENST00000370536#HMG#SOXp	FALSE
1252	ENSG00000039600	SOX30	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;	11063	SRY-box 30 [Source:HGNC Symbol;Acc:HGNC:30635]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	None	$#ENSP00000265007#ENSG00000039600#ENST00000265007#HMG#$#ENSP00000309343#ENSG00000039600#ENST00000311371#HMG#$#ENSP00000427984#ENSG00000039600#ENST00000519442#HMG#	FALSE
1253	ENSG00000124766	SOX4	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also binds ssDNA loops.	IPR009071;	6659	SRY-box 4 [Source:HGNC Symbol;Acc:HGNC:11200]	3U2B	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7706298	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000124766#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19147588$#ENSG00000124766#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16631117, PMID:7706298	$#ENSP00000244745#ENSG00000124766#ENST00000244745#HMG#	FALSE
1254	ENSG00000134532	SOX5	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;	6660	SRY-box 5 [Source:HGNC Symbol;Acc:HGNC:11201]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1396566;8078769;9755172	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000134532#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8812465	$#ENSP00000379328#ENSG00000134532#ENST00000396007#HMG#CENP-K$#ENSP00000398273#ENSG00000134532#ENST00000451604#HMG#$#ENSP00000437487#ENSG00000134532#ENST00000546136#HMG#$#ENSP00000393240#ENSG00000134532#ENST00000441133#HMG#$#ENSP00000441973#ENSG00000134532#ENST00000541536#HMG#$#ENSP00000443520#ENSG00000134532#ENST00000545921#HMG#$#ENSP00000442119#ENSG00000134532#ENST00000541847#HMG#	FALSE
1255	ENSG00000110693	SOX6	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;	102464826	SRY-box 6 [Source:HGNC Symbol;Acc:HGNC:16421]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7567444;11504872	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000110693#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1614875	$#ENSP00000379644#ENSG00000110693#ENST00000396356#HMG#$#ENSP00000434455#ENSG00000110693#ENST00000527619#HMG#$#ENSP00000433233#ENSG00000110693#ENST00000528429#HMG#$#ENSP00000432134#ENSG00000110693#ENST00000528252#HMG#$#ENSP00000434892#ENSG00000110693#ENST00000526673#HMG#	FALSE
1256	ENSG00000171056	SOX7	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR021934	83595	SRY-box 7 [Source:HGNC Symbol;Acc:HGNC:18196]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15220343	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000171056#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19108950$#ENSG00000171056#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000301921#ENSG00000171056#ENST00000304501#HMG#Sox17_18_mid	FALSE
1257	ENSG00000005513	SOX8	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR022151	30812	SRY-box 8 [Source:HGNC Symbol;Acc:HGNC:11203]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:12732652	No	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	$#ENSG00000005513#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000293894#ENSG00000005513#ENST00000293894#HMG#Sox_N	FALSE
1258	ENSG00000125398	SOX9	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also binds ssDNA loops.	IPR009071;IPR022151	6662	SRY-box 9 [Source:HGNC Symbol;Acc:HGNC:11204]	4EUW	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15590666	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000125398#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20484372, PMID:20530484, PMID:21367821$#ENSG00000125398#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10805756 | IMP - PMID:8640233$#ENSG00000125398#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:20484372, PMID:21412441	$#ENSP00000245479#ENSG00000125398#ENST00000245479#HMG#Sox_N	FALSE
1259	ENSG00000184895	SRY	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR017253	6736	sex determining region Y [Source:HGNC Symbol;Acc:HGNC:11311]	1HRY	DBD	Yes	None	None	a	Yes	TF Gene Candidate__DNA Binding_PMIDS:7813448;8190643	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000184895#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21412441	$#ENSP00000372547#ENSG00000184895#ENST00000383070#HMG#	FALSE
1260	ENSG00000149136	SSRP1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	HMG domain is highly divergent based on AA-sequence	IPR000969;IPR009071;IPR013719;IPR024954	6749	structure specific recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:11327]	None	not tested	not tested	None	None	x	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10336466	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000278412#ENSG00000149136#ENST00000278412#HMG#Rtt106, SSrecog$#ENSP00000431154#ENSG00000149136#ENST00000526696#HMG#SSrecog$#ENSP00000434546#ENSG00000149136#ENST00000529002#HMG#SSrecog$#ENSP00000489564#ENSG00000149136#ENST00000635721#HMG#	FALSE
1261	ENSG00000081059	TCF7	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR013558	6932	transcription factor 7 (T-cell specific, HMG-box) [Source:HGNC Symbol;Acc:HGNC:11639]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7579399	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000081059#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000340347#ENSG00000081059#ENST00000342854#HMG#CTNNB1_binding$#ENSP00000367822#ENSG00000081059#ENST00000378560#HMG#CTNNB1_binding$#ENSP00000378469#ENSG00000081059#ENST00000395023#HMG#CTNNB1_binding$#ENSP00000430179#ENSG00000081059#ENST00000518915#HMG#CTNNB1_binding$#ENSP00000430617#ENSG00000081059#ENST00000518887#HMG#CTNNB1_binding$#ENSP00000429935#ENSG00000081059#ENST00000520699#HMG#$#ENSP00000429547#ENSG00000081059#ENST00000520958#HMG#CTNNB1_binding	FALSE
1262	ENSG00000152284	TCF7L1	HMG/Sox	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009071;IPR013558	83439	transcription factor 7 like 1 [Source:HGNC Symbol;Acc:HGNC:11640]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2493990;14627819	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000152284#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11085512, PMID:1741298	$#ENSP00000282111#ENSG00000152284#ENST00000282111#HMG#CTNNB1_binding$#ENSP00000388984#ENSG00000152284#ENST00000442813#HMG#	FALSE
1263	ENSG00000148737	TCF7L2	HMG/Sox	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR009071;IPR013558	6934	transcription factor 7 like 2 [Source:HGNC Symbol;Acc:HGNC:11641]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__Other_PMIDS:12861022;15576399;9727977;15060161;15576399	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000148737#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9727977$#ENSG00000148737#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:12799378	$#ENSP00000344823#ENSG00000148737#ENST00000352065#HMG#CTNNB1_binding$#ENSP00000347949#ENSG00000148737#ENST00000355717#HMG#CTNNB1_binding$#ENSP00000348274#ENSG00000148737#ENST00000355995#HMG#CTNNB1_binding$#ENSP00000358404#ENSG00000148737#ENST00000369397#HMG#CTNNB1_binding$#ENSP00000443626#ENSG00000148737#ENST00000534894#HMG#CTNNB1_binding$#ENSP00000446238#ENSG00000148737#ENST00000536810#HMG#CTNNB1_binding$#ENSP00000446172#ENSG00000148737#ENST00000538897#HMG#CTNNB1_binding$#ENSP00000444972#ENSG00000148737#ENST00000543371#HMG#CTNNB1_binding$#ENSP00000440547#ENSG00000148737#ENST00000545257#HMG#CTNNB1_binding$#ENSP00000486891#ENSG00000148737#ENST00000627217#HMG#CTNNB1_binding$#ENSP00000487507#ENSG00000148737#ENST00000629706#HMG#CTNNB1_binding$#ENSP00000490260#ENSG00000148737#ENST00000466338#HMG#$#ENSP00000345640#ENSG00000148737#ENST00000346198#HMG#CTNNB1_binding$#ENSP00000358396#ENSG00000148737#ENST00000369389#HMG#CTNNB1_binding$#ENSP00000490478#ENSG00000148737#ENST00000637574#HMG#CTNNB1_binding	FALSE
1264	ENSG00000108064	TFAM	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	HMG domain is highly divergent based on AA-sequence	IPR009071;	7019	transcription factor A, mitochondrial [Source:HGNC Symbol;Acc:HGNC:11741]	3TMM	DBD and Full	not tested	None	Structure has long DNA-protein interaction interfaces and the TF works on mitochondrial genome	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2035027	Yes	1a1, Direct HQ evidence	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000108064#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036$#ENSG00000108064#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:22037171	$#ENSP00000420588#ENSG00000108064#ENST00000487519#HMG#$#ENSP00000363002#ENSG00000108064#ENST00000373895#HMG#$#ENSP00000378776#ENSG00000108064#ENST00000395377#HMG#	FALSE
1265	ENSG00000198846	TOX	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Predicted to be a non- or low specificity TF (PMID: 12697058). However, there is a DAM-id based motif with SSSSGNNGCG-consensus (PMID: 25527292), but this does not look like HMG-site	IPR009071;	9760	thymocyte selection associated high mobility group box [Source:HGNC Symbol;Acc:HGNC:18988]	None	not tested	Yes	None	None	x	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11850626;15078895	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	Yes	None	$#ENSP00000354842#ENSG00000198846#ENST00000361421#HMG#	FALSE
1266	ENSG00000124191	TOX2	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	TOX proteins are clearly their own distinct subfamily of HMG proteins.  No strong evidence for them binding DNA specifically.	IPR009071;	84969	TOX high mobility group box family member 2 [Source:HGNC Symbol;Acc:HGNC:16095]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000362090#ENSG00000124191#ENST00000372999#HMG#$#ENSP00000344724#ENSG00000124191#ENST00000341197#HMG#$#ENSP00000350849#ENSG00000124191#ENST00000358131#HMG#$#ENSP00000390278#ENSG00000124191#ENST00000423191#HMG#$#ENSP00000390876#ENSG00000124191#ENST00000413823#HMG#	FALSE
1267	ENSG00000103460	TOX3	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	TOX proteins are clearly their own distinct subfamily of HMG proteins.  No strong evidence for them binding DNA specifically.	IPR009071;	27324	TOX high mobility group box family member 3 [Source:HGNC Symbol;Acc:HGNC:11972]	None	DBD	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	c	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000219746#ENSG00000103460#ENST00000219746#HMG#$#ENSP00000385705#ENSG00000103460#ENST00000407228#HMG#$#ENSP00000457401#ENSG00000103460#ENST00000563091#HMG#	FALSE
1268	ENSG00000092203	TOX4	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	TOX proteins are clearly their own distinct subfamily of HMG proteins.  No strong evidence for them binding DNA specifically.	IPR009071;	9878	TOX high mobility group box family member 4 [Source:HGNC Symbol;Acc:HGNC:20161]	None	DBD	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	c	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	None	$#ENSP00000393080#ENSG00000092203#ENST00000448790#HMG#$#ENSP00000406196#ENSG00000092203#ENST00000457430#HMG#$#ENSP00000402195#ENSG00000092203#ENST00000416256#HMG#$#ENSP00000477868#ENSG00000092203#ENST00000613569#HMG#	FALSE
1269	ENSG00000108312	UBTF	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	No evidence for or against specific DNA-binding by this class of HMG box containing proteins	IPR009071;IPR029215	7343	upstream binding transcription factor, RNA polymerase I [Source:HGNC Symbol;Acc:HGNC:12511]	None	DBD	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Matt Weirauch	Yimeng Yin	Yes	None	$#ENSP00000345297#ENSG00000108312#ENST00000343638#HMG#$#ENSP00000377231#ENSG00000108312#ENST00000393606#HMG#$#ENSP00000435708#ENSG00000108312#ENST00000529383#HMG#$#ENSP00000302640#ENSG00000108312#ENST00000302904#HMG#$#ENSP00000390669#ENSG00000108312#ENST00000436088#HMG#$#ENSP00000431295#ENSG00000108312#ENST00000529373#HMG#	FALSE
1270	ENSG00000255009	UBTFL1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	No evidence for or against specific DNA-binding by this class of HMG box containing proteins	IPR009071	642623	upstream binding transcription factor, RNA polymerase I-like 1 [Source:HGNC Symbol;Acc:HGNC:14533]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000485108#ENSG00000255009#ENST00000530464#HMG#	FALSE
1271	ENSG00000198554	WDHD1	HMG/Sox	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Divergent HMG motif, doesnt cluster either with specific or nonspecific HMG proteins	IPR001680;IPR009071;IPR013979;IPR017986;IPR019775;IPR022100	11169	WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23170]	None	DBD	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000353793#ENSG00000198554#ENST00000360586#HMG#ANAPC4_WD40, Ge1_WD40, Mcl1_mid, WD40, eIF2A$#ENSP00000413435#ENSG00000198554#ENST00000455555#HMG#ANAPC4_WD40, Ge1_WD40, WD40$#ENSP00000399349#ENSG00000198554#ENST00000420358#HMG#ANAPC4_WD40, Mcl1_mid, WD40, eIF2A	FALSE
1272	ENSG00000237452	BHMG1	HMG/Sox; bHLH	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignment, it lacks a proper HMG domain. bHLH domain is also highly unlike any other human bHLH TF (<40% DBD ID)	IPR009071;IPR011598	388553	basic helix-loop-helix and HMG-box containing 1 [Source:HGNC Symbol;Acc:HGNC:44318]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000402674#ENSG00000237452#ENST00000457052#HMG#APC_basic	FALSE
1273	ENSG00000101126	ADNP	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR007087;IPR009057;IPR015880	23394	activity dependent neuroprotector homeobox [Source:HGNC Symbol;Acc:HGNC:15766]	None	DBD and Full	Yes	None	PMID: 25169753 Associated with autism and interacts with SWI/SNF nucleosome remodeling complex	b	Yes	No	No	3a, decent circumstantial evidence for its role as	Yimeng Yin	Matt Weirauch	Yes	None	$#ENSP00000342905#ENSG00000101126#ENST00000349014#Homeodomain#zf-C2H2_4$#ENSP00000360662#ENSG00000101126#ENST00000371602#Homeodomain#zf-C2H2_4$#ENSP00000379346#ENSG00000101126#ENST00000396029#Homeodomain#zf-C2H2_4$#ENSP00000379349#ENSG00000101126#ENST00000396032#Homeodomain#zf-C2H2_4$#ENSP00000436181#ENSG00000101126#ENST00000534467#Homeodomain#zf-Di19	FALSE
1274	ENSG00000101544	ADNP2	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR007087;IPR009057;IPR015880	22850	ADNP homeobox 2 [Source:HGNC Symbol;Acc:HGNC:23803]	None	DBD and Full	not tested	None	PMID:25169753;Homologous to ADNP that PMID: 25169753 Associated with autism and interacts with SWI/SNF nucleosome remodeling complex	b	Yes	No	No	3a, decent circumstantial evidence for its role as	Yimeng Yin	Matt Weirauch	Yes	None	$#ENSP00000262198#ENSG00000101544#ENST00000262198#Homeodomain#DUF4674, zf-C2H2_4$#ENSP00000453275#ENSG00000101544#ENST00000559951#Homeodomain#$#ENSP00000468397#ENSG00000101544#ENST00000560561#Homeodomain#$#ENSP00000467370#ENSG00000101544#ENST00000561195#Homeodomain#	FALSE
1275	ENSG00000180318	ALX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	8092	ALX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1494]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9753625;12390248;8756334;9847249;12390248	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000180318#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9753625$#ENSG00000180318#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8756334	$#ENSP00000315417#ENSG00000180318#ENST00000316824#Homeodomain#OAR	FALSE
1276	ENSG00000156150	ALX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	257	ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000358807#ENSG00000156150#ENST00000369792#Homeodomain#	FALSE
1277	ENSG00000052850	ALX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	60529	ALX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:450]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000052850#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000332744#ENSG00000052850#ENST00000329255#Homeodomain#OAR	FALSE
1278	ENSG00000227059	ANHX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	647589	anomalous homeobox [Source:HGNC Symbol;Acc:HGNC:40024]	None	not tested	Yes	None	TFs that are in CisBP but not in Vaquerizas set	No	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000409950#ENSG00000227059#ENST00000419717#Homeodomain#SIX1_SD$#ENSP00000439513#ENSG00000227059#ENST00000545940#Homeodomain#SIX1_SD	FALSE
1279	ENSG00000186103	ARGFX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	503582	arginine-fifty homeobox [Source:HGNC Symbol;Acc:HGNC:30146]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000335578#ENSG00000186103#ENST00000334384#Homeodomain#	FALSE
1280	ENSG00000004848	ARX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	170302	aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15930104	Yes	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000004848#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:16301625$#ENSG00000004848#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000368332#ENSG00000004848#ENST00000379044#Homeodomain#OAR$#ENSP00000490122#ENSG00000004848#ENST00000637993#Homeodomain#	FALSE
1281	ENSG00000125492	BARHL1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	56751	BarH like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:953]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:16226339	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000125492#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000125492#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000263610#ENSG00000125492#ENST00000263610#Homeodomain#$#ENSP00000444704#ENSG00000125492#ENST00000542090#Homeodomain#	FALSE
1282	ENSG00000143032	BARHL2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	343472	BarH like homeobox 2 [Source:HGNC Symbol;Acc:HGNC:954]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000143032#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000143032#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033	$#ENSP00000359474#ENSG00000143032#ENST00000370445#Homeodomain#	FALSE
1283	ENSG00000131668	BARX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	56033	BARX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:955]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__Transactivation_PMIDS:15809042;7669690;15809042	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000131668#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IBA - GO_REF:0000033$#ENSG00000131668#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10995576	$#ENSP00000253968#ENSG00000131668#ENST00000253968#Homeodomain#$#ENSP00000385613#ENSG00000131668#ENST00000401724#Homeodomain#	FALSE
1284	ENSG00000043039	BARX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	8538	BARX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:956]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14744868;15728386	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000043039#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:14744868	$#ENSP00000281437#ENSG00000043039#ENST00000281437#Homeodomain#	FALSE
1285	ENSG00000188909	BSX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	390259	brain specific homeobox [Source:HGNC Symbol;Acc:HGNC:20450]	None	DBD	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000188909#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000344285#ENSG00000188909#ENST00000343035#Homeodomain#	FALSE
1286	ENSG00000113722	CDX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR006820;IPR009057;IPR017970;IPR020479	1044	caudal type homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1805]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15677472;15774940;7585967;12954759	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000113722#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:15774940	$#ENSP00000231656#ENSG00000113722#ENST00000231656#Homeodomain#Caudal_act$#ENSP00000477928#ENSG00000113722#ENST00000616154#Homeodomain#Caudal_act	FALSE
1287	ENSG00000165556	CDX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR006820;IPR009057;IPR017970;IPR020479	1045	caudal type homeobox 2 [Source:HGNC Symbol;Acc:HGNC:1806]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7935448	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000165556#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15677472$#ENSG00000165556#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9459001	$#ENSP00000370408#ENSG00000165556#ENST00000381020#Homeodomain#Caudal_act	FALSE
1288	ENSG00000131264	CDX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR006820;IPR009057;IPR017970;IPR020479	1046	caudal type homeobox 4 [Source:HGNC Symbol;Acc:HGNC:1808]	None	Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000131264#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21471217 | IMP - PMID:21471217	$#ENSP00000362613#ENSG00000131264#ENST00000373514#Homeodomain#Caudal_act	FALSE
1289	ENSG00000143418	CERS2	Homeodomain	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905).	IPR001356;IPR006634;IPR009057;IPR016439	29956	ceramide synthase 2 [Source:HGNC Symbol;Acc:HGNC:14076]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000357950#ENSG00000143418#ENST00000368954#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453297#ENSG00000143418#ENST00000560793#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000355020#ENSG00000143418#ENST00000361419#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000452810#ENSG00000143418#ENST00000558062#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000393239#ENSG00000143418#ENST00000421609#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000394012#ENSG00000143418#ENST00000457392#Homeodomain#	FALSE
1290	ENSG00000154227	CERS3	Homeodomain	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905).	IPR001356;IPR006634;IPR009057;IPR016439	204219	ceramide synthase 3 [Source:HGNC Symbol;Acc:HGNC:23752]	None	DBD and Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000284382#ENSG00000154227#ENST00000284382#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000377672#ENSG00000154227#ENST00000394113#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000437640#ENSG00000154227#ENST00000538112#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453598#ENSG00000154227#ENST00000559639#Homeodomain#	FALSE
1291	ENSG00000090661	CERS4	Homeodomain	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905).	IPR001356;IPR006634;IPR009057;IPR016439	79603	ceramide synthase 4 [Source:HGNC Symbol;Acc:HGNC:23747]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Matt Weirauch	Pratyush Das	No	None	$#ENSP00000251363#ENSG00000090661#ENST00000251363#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453815#ENSG00000090661#ENST00000559336#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000453388#ENSG00000090661#ENST00000558268#Homeodomain#$#ENSP00000454122#ENSG00000090661#ENST00000558877#Homeodomain#TRAM_LAG1_CLN8	FALSE
1292	ENSG00000139624	CERS5	Homeodomain	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905).	IPR001356;IPR006634;IPR009057;IPR016439	91012	ceramide synthase 5 [Source:HGNC Symbol;Acc:HGNC:23749]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000325485#ENSG00000139624#ENST00000317551#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000389050#ENSG00000139624#ENST00000422340#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000448295#ENSG00000139624#ENST00000547800#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000449311#ENSG00000139624#ENST00000550919#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000447266#ENSG00000139624#ENST00000553122#Homeodomain#TRAM_LAG1_CLN8	FALSE
1293	ENSG00000172292	CERS6	Homeodomain	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Unlikely to be a TF - homeodomain is heavily truncated at the N-terminus; and LASS2/CERS2 has previously been shown to be involved in ceramide synthesis (PMID:20937905).	IPR001356;IPR006634;IPR009057;IPR016439	253782	ceramide synthase 6 [Source:HGNC Symbol;Acc:HGNC:23826]	None	DBD and Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000376453#ENSG00000172292#ENST00000392687#Homeodomain#TRAM_LAG1_CLN8$#ENSP00000306579#ENSG00000172292#ENST00000305747#Homeodomain#TRAM_LAG1_CLN8	FALSE
1294	ENSG00000105392	CRX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR013851;IPR017970	1406	cone-rod homeobox [Source:HGNC Symbol;Acc:HGNC:2383]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15001570;16332268	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000105392#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10625658$#ENSG00000105392#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000221996#ENSG00000105392#ENST00000221996#Homeodomain#TF_Otx$#ENSP00000478106#ENSG00000105392#ENST00000613299#Homeodomain#$#ENSP00000445565#ENSG00000105392#ENST00000539067#Homeodomain#TF_Otx$#ENSP00000457808#ENSG00000105392#ENST00000566686#Homeodomain#	FALSE
1295	ENSG00000109851	DBX1	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	120237	developing brain homeobox 1 [Source:HGNC Symbol;Acc:HGNC:33185]	None	DBD	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000436881#ENSG00000109851#ENST00000524983#Homeodomain#	FALSE
1296	ENSG00000185610	DBX2	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	440097	developing brain homeobox 2 [Source:HGNC Symbol;Acc:HGNC:33186]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000331470#ENSG00000185610#ENST00000332700#Homeodomain#	FALSE
1297	ENSG00000144355	DLX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	1745	distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Sam Lambert	Yes	None	$#ENSP00000341786#ENSG00000144355#ENST00000341900#Homeodomain#$#ENSP00000354478#ENSG00000144355#ENST00000361725#Homeodomain#$#ENSP00000448827#ENSG00000144355#ENST00000469444#Homeodomain#$#ENSP00000354865#ENSG00000144355#ENST00000361609#Homeodomain#	FALSE
1298	ENSG00000115844	DLX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;IPR022135	1746	distal-less homeobox 2 [Source:HGNC Symbol;Acc:HGNC:2915]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9415433;14769946	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000115844#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000115844#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1354641	$#ENSP00000234198#ENSG00000115844#ENST00000234198#Homeodomain#DLL_N$#ENSP00000446904#ENSG00000115844#ENST00000466293#Homeodomain#DLL_N	FALSE
1299	ENSG00000064195	DLX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;IPR022135	1747	distal-less homeobox 3 [Source:HGNC Symbol;Acc:HGNC:2916]	4XRS	DBD and Full	Yes	None	Heterodimer with MEIS1-DLX3	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:16687405	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000064195#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000064195#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9467018	$#ENSP00000389870#ENSG00000064195#ENST00000434704#Homeodomain#DLL_N$#ENSP00000449976#ENSG00000064195#ENST00000512495#Homeodomain#	FALSE
1300	ENSG00000108813	DLX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	1748	distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11909945	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000108813#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11909945$#ENSG00000108813#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11069021	$#ENSP00000240306#ENSG00000108813#ENST00000240306#Homeodomain#$#ENSP00000410622#ENSG00000108813#ENST00000411890#Homeodomain#$#ENSP00000480366#ENSG00000108813#ENST00000611342#Homeodomain#	FALSE
1301	ENSG00000105880	DLX5	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;IPR022135	1749	distal-less homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2918]	4RDU	DBD and Full	Yes	None	Monomer, makes a protein protein interaction on packing	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15383550	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000105880#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024	$#ENSP00000222598#ENSG00000105880#ENST00000222598#Homeodomain#DLL_N$#ENSP00000475008#ENSG00000105880#ENST00000486603#Homeodomain#DLL_N	FALSE
1302	ENSG00000006377	DLX6	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	1750	Distal-less homeobox 6 [Source:HGNC Symbol;Acc:HGNC:2919]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000006377#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7907794	$#ENSP00000428480#ENSG00000006377#ENST00000518156#Homeodomain#RskA$#ENSP00000451635#ENSG00000006377#ENST00000555308#Homeodomain#	FALSE
1303	ENSG00000197587	DMBX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	127343	diencephalon/mesencephalon homeobox 1 [Source:HGNC Symbol;Acc:HGNC:19026]	None	DBD	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12055180	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000197587#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000197587#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000353132#ENSG00000197587#ENST00000360032#Homeodomain#OAR$#ENSP00000361024#ENSG00000197587#ENST00000371956#Homeodomain#OAR	FALSE
1304	ENSG00000204595	DPRX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	503834	divergent-paired related homeobox [Source:HGNC Symbol;Acc:HGNC:32166]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000365838#ENSG00000204595#ENST00000376650#Homeodomain#	FALSE
1305	ENSG00000165606	DRGX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	644168	dorsal root ganglia homeobox [Source:HGNC Symbol;Acc:HGNC:21536]	None	DBD	not tested	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:12917357;14985445	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000363254#ENSG00000165606#ENST00000374139#Homeodomain#OAR$#ENSP00000401653#ENSG00000165606#ENST00000434016#Homeodomain#OAR	FALSE
1306	DUX1_HUMAN	DUX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Not included in Ensembl. Binds GATCTGAGTCTAATTGAGAATTACTGTAC in EMSA (PMID: 9736770)	None	None	double homeobox 1	None	not tested	not tested	None	Not included in Ensembl. Binds GATCTGAGTCTAATTGAGAATTACTGTAC in EMSA (PMID: 9736770)	No	Yes	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
1307	DUX3_HUMAN	DUX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Not included in Ensembl.	None	None	double homeobox 3	None	not tested	not tested	None	Not included in Ensembl.	No	Yes	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
1308	ENSG00000260596	DUX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000047;IPR001356;IPR009057;	107987491	double homeobox 4 [Source:HGNC Symbol;Acc:HGNC:50800]	None	not tested	Yes	None	ChIP-seq model in the Jaspar is similar to paralogous DUXA HT-SELEX model	No	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000458065#ENSG00000260596#ENST00000565211#Homeodomain#$#ENSP00000455112#ENSG00000260596#ENST00000570263#Homeodomain#$#ENSP00000456539#ENSG00000260596#ENST00000569241#Homeodomain#$#ENSP00000483555#ENSG00000260596#ENST00000616166#Homeodomain#	FALSE
1309	ENSG00000258873	DUXA	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;	503835	double homeobox A [Source:HGNC Symbol;Acc:HGNC:32179]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000452398#ENSG00000258873#ENST00000554048#Homeodomain#	FALSE
1310	ENSG00000135638	EMX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	2016	empty spiracles homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3340]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1352754	No	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	None	$#ENSP00000258106#ENSG00000135638#ENST00000258106#Homeodomain#$#ENSP00000482619#ENSG00000135638#ENST00000394111#Homeodomain#$#ENSP00000446992#ENSG00000135638#ENST00000473732#Homeodomain#	FALSE
1311	ENSG00000170370	EMX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	2018	empty spiracles homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3341]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1352754;16919471	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000450962#ENSG00000170370#ENST00000553456#Homeodomain#$#ENSP00000474874#ENSG00000170370#ENST00000442245#Homeodomain#$#ENSP00000480271#ENSG00000170370#ENST00000616794#Homeodomain#	FALSE
1312	ENSG00000163064	EN1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000747;IPR001356;IPR009057;IPR017970;IPR019549;IPR019737;IPR020479;	2019	engrailed homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3342]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:8096059;10504454	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000163064#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21672318	$#ENSP00000295206#ENSG00000163064#ENST00000295206#Homeodomain#Engrail_1_C_sig	FALSE
1313	ENSG00000164778	EN2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000747;IPR001356;IPR009057;IPR017970;IPR019549;IPR019737;IPR020479;	2020	engrailed homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3343]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:9813123	No	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	None	$#ENSP00000297375#ENSG00000164778#ENST00000297375#Homeodomain#Engrail_1_C_sig	FALSE
1314	ENSG00000123576	ESX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR013847;IPR017970	80712	ESX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14865]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10611245	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000123576#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15897875 | IMP - PMID:15897875	$#ENSP00000361669#ENSG00000123576#ENST00000372588#Homeodomain#	FALSE
1315	ENSG00000106038	EVX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	2128	even-skipped homeobox 1 [Source:HGNC Symbol;Acc:HGNC:3506]	None	DBD	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000106038#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1684419	$#ENSP00000222761#ENSG00000106038#ENST00000222761#Homeodomain#$#ENSP00000419266#ENSG00000106038#ENST00000496902#Homeodomain#$#ENSP00000463759#ENSG00000106038#ENST00000580535#Homeodomain#	FALSE
1316	ENSG00000174279	EVX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	344191	even-skipped homeobox 2 [Source:HGNC Symbol;Acc:HGNC:3507]	None	DBD	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__Transactivation_PMIDS:8978698	No	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000312385#ENSG00000174279#ENST00000308618#Homeodomain#	FALSE
1317	ENSG00000164900	GBX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	2636	gastrulation brain homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4185]	2ME6	DBD	Yes	None	NMR structure of monomer	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	None	$#ENSP00000297537#ENSG00000164900#ENST00000297537#Homeodomain#	FALSE
1318	ENSG00000168505	GBX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	2637	gastrulation brain homeobox 2 [Source:HGNC Symbol;Acc:HGNC:4186]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10690529	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000168505#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9346236	$#ENSP00000302251#ENSG00000168505#ENST00000306318#Homeodomain#$#ENSP00000448747#ENSG00000168505#ENST00000551105#Homeodomain#	FALSE
1319	ENSG00000133937	GSC	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	145258	goosecoid homeobox [Source:HGNC Symbol;Acc:HGNC:4612]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9417125;10542273	No	1a1, Direct HQ evidence	Matt Weirauch	Tim Hughes	Yes	None	$#ENSP00000238558#ENSG00000133937#ENST00000238558#Homeodomain#	FALSE
1320	ENSG00000063515	GSC2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	2928	goosecoid homeobox 2 [Source:HGNC Symbol;Acc:HGNC:4613]	None	DBD	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Tim Hughes	Yes	$#ENSG00000063515#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9700206	$#ENSP00000086933#ENSG00000063515#ENST00000086933#Homeodomain#	FALSE
1321	ENSG00000169840	GSX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	219409	GS homeobox 1 [Source:HGNC Symbol;Acc:HGNC:20374]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11731616	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000169840#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000304331#ENSG00000169840#ENST00000302945#Homeodomain#	FALSE
1322	ENSG00000180613	GSX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	170825	GS homeobox 2 [Source:HGNC Symbol;Acc:HGNC:24959]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7619729	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000319118#ENSG00000180613#ENST00000326902#Homeodomain#$#ENSP00000483522#ENSG00000180613#ENST00000611459#Homeodomain#$#ENSP00000422213#ENSG00000180613#ENST00000503800#Homeodomain#	FALSE
1323	ENSG00000165259	HDX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057	139324	highly divergent homeobox [Source:HGNC Symbol;Acc:HGNC:26411]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	None	$#ENSP00000297977#ENSG00000165259#ENST00000297977#Homeodomain#$#ENSP00000362272#ENSG00000165259#ENST00000373177#Homeodomain#$#ENSP00000423670#ENSG00000165259#ENST00000506585#Homeodomain#$#ENSP00000387790#ENSG00000165259#ENST00000449553#Homeodomain#	FALSE
1324	ENSG00000163666	HESX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	8820	HESX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4877]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9620767;11748154;12063185	No	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	None	$#ENSP00000295934#ENSG00000163666#ENST00000295934#Homeodomain#$#ENSP00000419615#ENSG00000163666#ENST00000495160#Homeodomain#$#ENSP00000418918#ENSG00000163666#ENST00000473921#Homeodomain#	FALSE
1325	ENSG00000152804	HHEX	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3087	hematopoietically expressed homeobox [Source:HGNC Symbol;Acc:HGNC:4901]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16146628	Yes	1a2, Orthologous HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000152804#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15016828	$#ENSP00000282728#ENSG00000152804#ENST00000282728#Homeodomain#$#ENSP00000447953#ENSG00000152804#ENST00000492654#Homeodomain#$#ENSP00000450017#ENSG00000152804#ENST00000472590#Homeodomain#	FALSE
1326	ENSG00000136630	HLX	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	3142	H2.0 like homeobox [Source:HGNC Symbol;Acc:HGNC:4978]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	None	$#ENSP00000355870#ENSG00000136630#ENST00000366903#Homeodomain#$#ENSP00000408248#ENSG00000136630#ENST00000427693#Homeodomain#	FALSE
1327	ENSG00000147421	HMBOX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006899;IPR009057;IPR010982	79618	homeobox containing 1 [Source:HGNC Symbol;Acc:HGNC:26137]	4J19	DBD and Full	Yes	None	Structure is a homodimer	b	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	None	$#ENSP00000287701#ENSG00000147421#ENST00000287701#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37$#ENSP00000380516#ENSG00000147421#ENST00000397358#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37$#ENSP00000452827#ENSG00000147421#ENST00000523613#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37$#ENSP00000430110#ENSG00000147421#ENST00000524238#Homeodomain#HNF-1_N, HTH_19, HTH_3, HTH_37	FALSE
1328	ENSG00000215612	HMX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3166	H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5017]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000215612#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000383516#ENSG00000215612#ENST00000400677#Homeodomain#$#ENSP00000446997#ENSG00000215612#ENST00000506970#Homeodomain#	FALSE
1329	ENSG00000188816	HMX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3167	H6 family homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5018]	None	DBD and Full	Yes	None	None	c	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10543441;15363417	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000341108#ENSG00000188816#ENST00000339992#Homeodomain#	FALSE
1330	ENSG00000188620	HMX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	340784	H6 family homeobox 3 [Source:HGNC Symbol;Acc:HGNC:5019]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000350549#ENSG00000188620#ENST00000357878#Homeodomain#	FALSE
1331	ENSG00000135100	HNF1A	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006897;IPR006898;IPR006899;IPR009057;IPR010982;IPR023219;	6927	HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621]	1IC8	DBD and Full	not tested	None	Structure has two HNF1A proteins, both of which have two homeodomains	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8373770;16603721;9047360	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000135100#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000135100#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11980910	$#ENSP00000257555#ENSG00000135100#ENST00000257555#Homeodomain#HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin$#ENSP00000443112#ENSG00000135100#ENST00000541395#Homeodomain#HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin$#ENSP00000438804#ENSG00000135100#ENST00000544413#Homeodomain#HNF-1A_C, HNF-1B_C, HNF-1_N, Telethonin$#ENSP00000481967#ENSG00000135100#ENST00000617366#Homeodomain#HNF-1_N, Telethonin$#ENSP00000476181#ENSG00000135100#ENST00000400024#Homeodomain#HNF-1B_C, HNF-1_N, Telethonin	FALSE
1332	ENSG00000275410	HNF1B	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006897;IPR006899;IPR009057;IPR010982;IPR023219	6928	HNF1 homeobox B [Source:HGNC Symbol;Acc:HGNC:11630]	2H8R	DBD and Full	not tested	None	Structure has two HNF1A proteins, both of which have two homeodomains	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9774468	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000275410#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16297991$#ENSG00000275410#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000477524#ENSG00000275410#ENST00000613727#Homeodomain#HNF-1B_C, HNF-1_N$#ENSP00000478682#ENSG00000275410#ENST00000617272#Homeodomain#HNF-1B_C, HNF-1_N$#ENSP00000480291#ENSG00000275410#ENST00000617811#Homeodomain#HNF-1B_C, HNF-1_N$#ENSP00000482711#ENSG00000275410#ENST00000621123#Homeodomain#HNF-1B_C, HNF-1_N	FALSE
1333	ENSG00000215271	HOMEZ	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;IPR024578	57594	homeobox and leucine zipper encoding [Source:HGNC Symbol;Acc:HGNC:20164]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000215271#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000350049#ENSG00000215271#ENST00000357460#Homeodomain#$#ENSP00000453979#ENSG00000215271#ENST00000561013#Homeodomain#$#ENSP00000475307#ENSG00000215271#ENST00000606731#Homeodomain#	FALSE
1334	ENSG00000171476	HOPX	Homeodomain	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Lacks conserved residues required for DNA binding (PMID: 24287901)	IPR001356;IPR009057	84525	HOP homeobox [Source:HGNC Symbol;Acc:HGNC:24961]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000315198#ENSG00000171476#ENST00000317745#Homeodomain#$#ENSP00000337330#ENSG00000171476#ENST00000337881#Homeodomain#$#ENSP00000424101#ENSG00000171476#ENST00000503639#Homeodomain#$#ENSP00000452003#ENSG00000171476#ENST00000556614#Homeodomain#$#ENSP00000370654#ENSG00000171476#ENST00000381255#Homeodomain#$#ENSP00000422175#ENSG00000171476#ENST00000508121#Homeodomain#$#ENSP00000452340#ENSG00000171476#ENST00000553379#Homeodomain#$#ENSP00000370659#ENSG00000171476#ENST00000381260#Homeodomain#$#ENSP00000452098#ENSG00000171476#ENST00000555760#Homeodomain#$#ENSP00000451794#ENSG00000171476#ENST00000556376#Homeodomain#	FALSE
1335	ENSG00000105991	HOXA1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3198	Homeobox A1 [Source:HGNC Symbol;Acc:HGNC:5099]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000343246#ENSG00000105991#ENST00000343060#Homeodomain#$#ENSP00000347851#ENSG00000105991#ENST00000355633#Homeodomain#	FALSE
1336	ENSG00000253293	HOXA10	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3206	homeobox A10 [Source:HGNC Symbol;Acc:HGNC:5100]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:14512427;15886193	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000253293#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21471217	$#ENSP00000283921#ENSG00000253293#ENST00000283921#Homeodomain#$#ENSP00000379633#ENSG00000253293#ENST00000396344#Homeodomain#$#ENSP00000479619#ENSG00000253293#ENST00000613671#Homeodomain#	FALSE
1337	ENSG00000005073	HOXA11	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also forms heterodimers with MEIS and PBX.	IPR001356;IPR009057;IPR017970;IPR020479;IPR021918;	3207	homeobox A11 [Source:HGNC Symbol;Acc:HGNC:5101]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9079637;12533430;14706073	No	1a1, Direct HQ evidence	Jussi Taipale	Mihai Albu	Yes	None	$#ENSP00000006015#ENSG00000005073#ENST00000006015#Homeodomain#DUF3528$#ENSP00000448962#ENSG00000005073#ENST00000517402#Homeodomain#DUF3528	FALSE
1338	ENSG00000106031	HOXA13	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR022067	3209	homeobox A13 [Source:HGNC Symbol;Acc:HGNC:5102]	2LD5	DBD and Full	Yes	None	NMR structure with a moderate affinity sequence	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000222753#ENSG00000106031#ENST00000222753#Homeodomain#HoxA13_N	FALSE
1339	ENSG00000105996	HOXA2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;	3199	homeobox A2 [Source:HGNC Symbol;Acc:HGNC:5103]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15634706	No	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000105996#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000222718#ENSG00000105996#ENST00000222718#Homeodomain#	FALSE
1340	ENSG00000105997	HOXA3	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;IPR025281	3200	homeobox A3 [Source:HGNC Symbol;Acc:HGNC:5104]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8096059;15914537	No	1a1, Direct HQ evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000105997#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000379640#ENSG00000105997#ENST00000396352#Homeodomain#DUF4074$#ENSP00000484411#ENSG00000105997#ENST00000612286#Homeodomain#DUF4074$#ENSP00000429426#ENSG00000105997#ENST00000522788#Homeodomain#$#ENSP00000430566#ENSG00000105997#ENST00000522456#Homeodomain#	FALSE
1341	ENSG00000197576	HOXA4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3201	homeobox A4 [Source:HGNC Symbol;Acc:HGNC:5105]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000197576#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000353151#ENSG00000197576#ENST00000360046#Homeodomain#$#ENSP00000408845#ENSG00000197576#ENST00000428284#Homeodomain#$#ENSP00000448015#ENSG00000197576#ENST00000511914#Homeodomain#$#ENSP00000479166#ENSG00000197576#ENST00000610970#Homeodomain#	FALSE
1342	ENSG00000106004	HOXA5	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3202	homeobox A5 [Source:HGNC Symbol;Acc:HGNC:5106]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10879542	Yes	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000106004#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10879542$#ENSG00000106004#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10879542, PMID:16756717	$#ENSP00000222726#ENSG00000106004#ENST00000222726#Homeodomain#	FALSE
1343	ENSG00000106006	HOXA6	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3203	homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000106006#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000222728#ENSG00000106006#ENST00000222728#Homeodomain#	FALSE
1344	ENSG00000122592	HOXA7	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3204	homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7911971	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000122592#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11435435	$#ENSP00000242159#ENSG00000122592#ENST00000242159#Homeodomain#$#ENSP00000428563#ENSG00000122592#ENST00000519842#Homeodomain#	FALSE
1345	ENSG00000078399	HOXA9	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479	442920	homeobox A9 [Source:HGNC Symbol;Acc:HGNC:5109]	1PUF	DBD and Full	Yes	None	Structure is a heterodimer of HoxA9 and Pbx1	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11042172	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000343619#ENSG00000078399#ENST00000343483#Homeodomain#Hox9_act$#ENSP00000379634#ENSG00000078399#ENST00000396345#Homeodomain#Hox9_act	FALSE
1346	ENSG00000120094	HOXB1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3211	homeobox B1 [Source:HGNC Symbol;Acc:HGNC:5111]	1B72	DBD and Full	not tested	None	Structure is a heterodimer of HOXB1 and PBX1	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7911971;9242495	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000355140#ENSG00000120094#ENST00000239174#Homeodomain#$#ENSP00000459066#ENSG00000120094#ENST00000577092#Homeodomain#	FALSE
1347	ENSG00000159184	HOXB13	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also forms heterodimers.	IPR001356;IPR009057;IPR017970;IPR022067	10481	homeobox B13 [Source:HGNC Symbol;Acc:HGNC:5112]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15126340;15604291	No	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	None	$#ENSP00000290295#ENSG00000159184#ENST00000290295#Homeodomain#HoxA13_N	FALSE
1348	ENSG00000173917	HOXB2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;	3212	homeobox B2 [Source:HGNC Symbol;Acc:HGNC:5113]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15289435	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000173917#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000331741#ENSG00000173917#ENST00000330070#Homeodomain#	FALSE
1349	ENSG00000120093	HOXB3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;IPR025281	3213	homeobox B3 [Source:HGNC Symbol;Acc:HGNC:5114]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9556594;12482716	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000120093#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000308252#ENSG00000120093#ENST00000311626#Homeodomain#DUF4074$#ENSP00000417207#ENSG00000120093#ENST00000470495#Homeodomain#DUF4074$#ENSP00000418892#ENSG00000120093#ENST00000476342#Homeodomain#DUF4074$#ENSP00000449977#ENSG00000120093#ENST00000490677#Homeodomain#DUF4074$#ENSP00000419676#ENSG00000120093#ENST00000472863#Homeodomain#DUF4074$#ENSP00000418729#ENSG00000120093#ENST00000489475#Homeodomain#DUF4074$#ENSP00000420595#ENSG00000120093#ENST00000498678#Homeodomain#DUF4074$#ENSP00000446783#ENSG00000120093#ENST00000465120#Homeodomain#	FALSE
1350	ENSG00000182742	HOXB4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3214	homeobox B4 [Source:HGNC Symbol;Acc:HGNC:5115]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12482716;12489992;15634700	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000182742#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000328928#ENSG00000182742#ENST00000332503#Homeodomain#	FALSE
1351	ENSG00000120075	HOXB5	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3215	homeobox B5 [Source:HGNC Symbol;Acc:HGNC:5116]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12897140	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000120075#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000239151#ENSG00000120075#ENST00000239151#Homeodomain#	FALSE
1352	ENSG00000108511	HOXB6	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3216	homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000108511#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000225648#ENSG00000108511#ENST00000225648#Homeodomain#$#ENSP00000420009#ENSG00000108511#ENST00000484302#Homeodomain#	FALSE
1353	ENSG00000260027	HOXB7	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3217	homeobox B7 [Source:HGNC Symbol;Acc:HGNC:5118]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1357628;8756643	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000260027#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1678287	$#ENSP00000239165#ENSG00000260027#ENST00000239165#Homeodomain#	FALSE
1354	ENSG00000120068	HOXB8	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR001827;IPR009057;IPR017970;IPR020479	3218	homeobox B8 [Source:HGNC Symbol;Acc:HGNC:5119]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; TF PPI_PMIDS:11571641;15886193	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000120068#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000239144#ENSG00000120068#ENST00000239144#Homeodomain#$#ENSP00000460659#ENSG00000120068#ENST00000576562#Homeodomain#$#ENSP00000460254#ENSG00000120068#ENST00000498634#Homeodomain#	FALSE
1355	ENSG00000170689	HOXB9	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479	3219	homeobox B9 [Source:HGNC Symbol;Acc:HGNC:5120]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:1347944;9079637;10617598;11432851	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000309439#ENSG00000170689#ENST00000311177#Homeodomain#Hox9_act	FALSE
1356	ENSG00000180818	HOXC10	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3226	homeobox C10 [Source:HGNC Symbol;Acc:HGNC:5122]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10835276;10835276;12917416	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000307321#ENSG00000180818#ENST00000303460#Homeodomain#$#ENSP00000421946#ENSG00000180818#ENST00000515593#Homeodomain#	FALSE
1357	ENSG00000123388	HOXC11	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479;IPR021918;	3227	homeobox C11 [Source:HGNC Symbol;Acc:HGNC:5123]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9582375	Yes	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000123388#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9582375	$#ENSP00000446680#ENSG00000123388#ENST00000546378#Homeodomain#DUF3528$#ENSP00000243082#ENSG00000123388#ENST00000243082#Homeodomain#DUF3528	FALSE
1358	ENSG00000123407	HOXC12	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3228	homeobox C12 [Source:HGNC Symbol;Acc:HGNC:5124]	None	DBD	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000243103#ENSG00000123407#ENST00000243103#Homeodomain#	FALSE
1359	ENSG00000123364	HOXC13	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR022067	3229	homeobox C13 [Source:HGNC Symbol;Acc:HGNC:5125]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000123364#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000243056#ENSG00000123364#ENST00000243056#Homeodomain#HoxA13_N	FALSE
1360	ENSG00000198353	HOXC4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3221	homeobox C4 [Source:HGNC Symbol;Acc:HGNC:5126]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15252056	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000198353#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000305973#ENSG00000198353#ENST00000303406#Homeodomain#$#ENSP00000399808#ENSG00000198353#ENST00000430889#Homeodomain#	FALSE
1361	ENSG00000172789	HOXC5	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3222	homeobox C5 [Source:HGNC Symbol;Acc:HGNC:5127]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000172789#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000309336#ENSG00000172789#ENST00000312492#Homeodomain#	FALSE
1362	ENSG00000197757	HOXC6	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3223	homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8393570;8870653	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000197757#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000243108#ENSG00000197757#ENST00000243108#Homeodomain#$#ENSP00000377864#ENSG00000197757#ENST00000394331#Homeodomain#$#ENSP00000424124#ENSG00000197757#ENST00000504315#Homeodomain#$#ENSP00000423898#ENSG00000197757#ENST00000509328#Homeodomain#	FALSE
1363	ENSG00000037965	HOXC8	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR001827;IPR009057;IPR017970;IPR020479	3224	homeobox C8 [Source:HGNC Symbol;Acc:HGNC:5129]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000037965#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000040584#ENSG00000037965#ENST00000040584#Homeodomain#	FALSE
1364	ENSG00000180806	HOXC9	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479	3225	homeobox C9 [Source:HGNC Symbol;Acc:HGNC:5130]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	None	$#ENSP00000302836#ENSG00000180806#ENST00000303450#Homeodomain#Hox9_act$#ENSP00000423861#ENSG00000180806#ENST00000508190#Homeodomain#Hox9_act	FALSE
1365	ENSG00000128645	HOXD1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	102465802	homeobox D1 [Source:HGNC Symbol;Acc:HGNC:5132]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11775067	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000328598#ENSG00000128645#ENST00000331462#Homeodomain#	FALSE
1366	ENSG00000128710	HOXD10	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3236	homeobox D10 [Source:HGNC Symbol;Acc:HGNC:5133]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:11432851;14743444;15792957	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000128710#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000249501#ENSG00000128710#ENST00000249501#Homeodomain#	FALSE
1367	ENSG00000128713	HOXD11	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479;IPR021918;	3237	homeobox D11 [Source:HGNC Symbol;Acc:HGNC:5134]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Pratyush Das	Yes	None	$#ENSP00000249504#ENSG00000128713#ENST00000249504#Homeodomain#DUF3528$#ENSP00000480304#ENSG00000128713#ENST00000619244#Homeodomain#DUF3528	FALSE
1368	ENSG00000170178	HOXD12	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3238	homeobox D12 [Source:HGNC Symbol;Acc:HGNC:5135]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11036080	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000385132#ENSG00000170178#ENST00000404162#Homeodomain#$#ENSP00000385586#ENSG00000170178#ENST00000406506#Homeodomain#	FALSE
1369	ENSG00000128714	HOXD13	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR022067	3239	homeobox D13 [Source:HGNC Symbol;Acc:HGNC:5136]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16314414	Yes	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000128714#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000128714#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:24789103$#ENSG00000128714#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000376322#ENSG00000128714#ENST00000392539#Homeodomain#HoxA13_N	FALSE
1370	ENSG00000128652	HOXD3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;IPR025281	3232	homeobox D3 [Source:HGNC Symbol;Acc:HGNC:5137]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14610084	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000128652#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000249440#ENSG00000128652#ENST00000249440#Homeodomain#DUF4074$#ENSP00000392615#ENSG00000128652#ENST00000432796#Homeodomain#$#ENSP00000386498#ENSG00000128652#ENST00000410016#Homeodomain#DUF4074	FALSE
1371	ENSG00000170166	HOXD4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR017995;IPR020479	3233	homeobox D4 [Source:HGNC Symbol;Acc:HGNC:5138]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1756725	No	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000170166#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000302548#ENSG00000170166#ENST00000306324#Homeodomain#	FALSE
1372	ENSG00000175879	HOXD8	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001827;IPR009057;IPR017970;IPR020479;	3234	homeobox D8 [Source:HGNC Symbol;Acc:HGNC:5139]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:8890171	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000175879#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1756725	$#ENSP00000409026#ENSG00000175879#ENST00000450510#Homeodomain#$#ENSP00000315949#ENSG00000175879#ENST00000313173#Homeodomain#$#ENSP00000406045#ENSG00000175879#ENST00000429017#Homeodomain#$#ENSP00000437431#ENSG00000175879#ENST00000544999#Homeodomain#	FALSE
1373	ENSG00000128709	HOXD9	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR006711;IPR009057;IPR017112;IPR017970;IPR020479	3235	homeobox D9 [Source:HGNC Symbol;Acc:HGNC:5140]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8890171	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000128709#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1756725	$#ENSP00000249499#ENSG00000128709#ENST00000249499#Homeodomain#Hox9_act	FALSE
1374	ENSG00000170549	IRX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001356;IPR003893;IPR008422;IPR009057;IPR017970;	79192	iroquois homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14358]	None	DBD	not tested	None	None	a	Yes	TF Gene Candidate___PMIDS:0	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000305244#ENSG00000170549#ENST00000302006#Homeodomain#	FALSE
1375	ENSG00000170561	IRX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003893;IPR008422;IPR009057;IPR017970;	153572	iroquois homeobox 2 [Source:HGNC Symbol;Acc:HGNC:14359]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	None	$#ENSP00000307006#ENSG00000170561#ENST00000302057#Homeodomain#$#ENSP00000372056#ENSG00000170561#ENST00000382611#Homeodomain#	FALSE
1376	ENSG00000177508	IRX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003893;IPR008422;IPR009057;IPR017970;	79191	iroquois homeobox 3 [Source:HGNC Symbol;Acc:HGNC:14360]	None	DBD	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:16203991	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000331608#ENSG00000177508#ENST00000329734#Homeodomain#$#ENSP00000463991#ENSG00000177508#ENST00000558054#Homeodomain#	FALSE
1377	ENSG00000113430	IRX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR003893;IPR008422;IPR009057;IPR017970;	50805	iroquois homeobox 4 [Source:HGNC Symbol;Acc:HGNC:6129]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__Other_PMIDS:10625552;11238910	No	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000231357#ENSG00000113430#ENST00000231357#Homeodomain#$#ENSP00000423161#ENSG00000113430#ENST00000505790#Homeodomain#$#ENSP00000424235#ENSG00000113430#ENST00000513692#Homeodomain#$#ENSP00000482393#ENSG00000113430#ENST00000613726#Homeodomain#$#ENSP00000481396#ENSG00000113430#ENST00000622814#Homeodomain#$#ENSP00000421772#ENSG00000113430#ENST00000511126#Homeodomain#Homeobox_KN	FALSE
1378	ENSG00000176842	IRX5	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003893;IPR008422;IPR009057;IPR017970;	10265	iroquois homeobox 5 [Source:HGNC Symbol;Acc:HGNC:14361]	None	DBD	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000316250#ENSG00000176842#ENST00000320990#Homeodomain#$#ENSP00000483446#ENSG00000176842#ENST00000620085#Homeodomain#$#ENSP00000378132#ENSG00000176842#ENST00000394636#Homeodomain#$#ENSP00000453660#ENSG00000176842#ENST00000560154#Homeodomain#	FALSE
1379	ENSG00000159387	IRX6	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003893;IPR008422;IPR009057;IPR017970;	79190	iroquois homeobox 6 [Source:HGNC Symbol;Acc:HGNC:14675]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate__Other_PMIDS:11335133	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000290552#ENSG00000159387#ENST00000290552#Homeodomain#	FALSE
1380	ENSG00000016082	ISL1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	3670	ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15253934;16321656	No	1a1, Direct HQ evidence	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000016082#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000230658#ENSG00000016082#ENST00000230658#Homeodomain#LIM$#ENSP00000422676#ENSG00000016082#ENST00000511384#Homeodomain#LIM	FALSE
1381	ENSG00000159556	ISL2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	64843	ISL LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18524]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15048808	No	1a1, Direct HQ evidence	Laura Campitelli	Matt Weirauch	Yes	None	$#ENSP00000290759#ENSG00000159556#ENST00000290759#Homeodomain#LIM	FALSE
1382	ENSG00000175329	ISX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	91464	intestine specific homeobox [Source:HGNC Symbol;Acc:HGNC:28084]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000175329#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000311492#ENSG00000175329#ENST00000308700#Homeodomain#$#ENSP00000386037#ENSG00000175329#ENST00000404699#Homeodomain#	FALSE
1383	ENSG00000138136	LBX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970	10660	ladybird homeobox 1 [Source:HGNC Symbol;Acc:HGNC:16960]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7909370;8645601;12358782;15528197	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000138136#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000359212#ENSG00000138136#ENST00000370193#Homeodomain#	FALSE
1384	ENSG00000179528	LBX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057	85474	ladybird homeobox 2 [Source:HGNC Symbol;Acc:HGNC:15525]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000366789#ENSG00000179528#ENST00000377566#Homeodomain#$#ENSP00000417116#ENSG00000179528#ENST00000460508#Homeodomain#$#ENSP00000450229#ENSG00000179528#ENST00000341396#Homeodomain#	FALSE
1385	ENSG00000213921	LEUTX	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR009057;IPR017970;	342900	leucine twenty homeobox [Source:HGNC Symbol;Acc:HGNC:31953]	None	DBD	not tested	None	PMID:27412763 Expressed in early embryo as transcripts that contain a full homeodomain	b	Yes	No	No	3a, decent circumstantial evidence for its role as	Pratyush Das	Sam Lambert	Yes	None	$#ENSP00000380053#ENSG00000213921#ENST00000396841#Homeodomain#	FALSE
1386	ENSG00000273706	LHX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	3975	LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6593]	None	DBD	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10926781	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000273706#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000477829#ENSG00000273706#ENST00000614239#Homeodomain#LIM$#ENSP00000481496#ENSG00000273706#ENST00000621767#Homeodomain#	FALSE
1387	ENSG00000106689	LHX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001356;IPR001781;IPR009057;IPR017970	9355	LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:6594]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7513049;10593900	No	1a1, Direct HQ evidence	Matt Weirauch	Tim Hughes	Yes	None	$#ENSP00000362717#ENSG00000106689#ENST00000373615#Homeodomain#LIM$#ENSP00000394978#ENSG00000106689#ENST00000446480#Homeodomain#LIM$#ENSP00000476200#ENSG00000106689#ENST00000488674#Homeodomain#$#ENSP00000453448#ENSG00000106689#ENST00000560961#Homeodomain#LIM	FALSE
1388	ENSG00000107187	LHX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	8022	LIM homeobox 3 [Source:HGNC Symbol;Acc:HGNC:6595]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15271874	No	1a1, Direct HQ evidence	Tim Hughes	Yimeng Yin	Yes	None	$#ENSP00000360811#ENSG00000107187#ENST00000371746#Homeodomain#LIM$#ENSP00000360813#ENSG00000107187#ENST00000371748#Homeodomain#LIM$#ENSP00000483080#ENSG00000107187#ENST00000619587#Homeodomain#LIM	FALSE
1389	ENSG00000121454	LHX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	89884	LIM homeobox 4 [Source:HGNC Symbol;Acc:HGNC:21734]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Other; Transactivation_PMIDS:12118377;15998782	No	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	None	$#ENSP00000263726#ENSG00000121454#ENST00000263726#Homeodomain#LIM	FALSE
1390	ENSG00000089116	LHX5	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	64211	LIM homeobox 5 [Source:HGNC Symbol;Acc:HGNC:14216]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific__PMIDS:0	No	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	None	$#ENSP00000261731#ENSG00000089116#ENST00000261731#Homeodomain#LIM	FALSE
1391	ENSG00000106852	LHX6	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	26468	LIM homeobox 6 [Source:HGNC Symbol;Acc:HGNC:21735]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000106852#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10393337	$#ENSP00000340137#ENSG00000106852#ENST00000340587#Homeodomain#LIM$#ENSP00000362859#ENSG00000106852#ENST00000373754#Homeodomain#LIM$#ENSP00000362860#ENSG00000106852#ENST00000373755#Homeodomain#LIM$#ENSP00000377854#ENSG00000106852#ENST00000394319#Homeodomain#LIM$#ENSP00000452811#ENSG00000106852#ENST00000464484#Homeodomain#$#ENSP00000453798#ENSG00000106852#ENST00000482062#Homeodomain#$#ENSP00000441464#ENSG00000106852#ENST00000541397#Homeodomain#LIM$#ENSP00000475927#ENSG00000106852#ENST00000559895#Homeodomain#	FALSE
1392	ENSG00000162624	LHX8	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	431707	LIM homeobox 8 [Source:HGNC Symbol;Acc:HGNC:28838]	None	DBD and Full	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000294638#ENSG00000162624#ENST00000294638#Homeodomain#DUF2175, LIM$#ENSP00000348597#ENSG00000162624#ENST00000356261#Homeodomain#DUF2175, LIM	FALSE
1393	ENSG00000143355	LHX9	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001356;IPR001781;IPR009057;IPR017970	56956	LIM homeobox 9 [Source:HGNC Symbol;Acc:HGNC:14222]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000356357#ENSG00000143355#ENST00000367387#Homeodomain#LIM$#ENSP00000356360#ENSG00000143355#ENST00000367390#Homeodomain#LIM$#ENSP00000482898#ENSG00000143355#ENST00000475727#Homeodomain#$#ENSP00000356358#ENSG00000143355#ENST00000367388#Homeodomain#$#ENSP00000483170#ENSG00000143355#ENST00000606127#Homeodomain#	FALSE
1394	ENSG00000162761	LMX1A	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	4009	LIM homeobox transcription factor 1 alpha [Source:HGNC Symbol;Acc:HGNC:6653]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000294816#ENSG00000162761#ENST00000294816#Homeodomain#LIM$#ENSP00000340226#ENSG00000162761#ENST00000342310#Homeodomain#LIM$#ENSP00000356868#ENSG00000162761#ENST00000367893#Homeodomain#LIM	FALSE
1395	ENSG00000136944	LMX1B	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001781;IPR009057;IPR017970	4010	LIM homeobox transcription factor 1 beta [Source:HGNC Symbol;Acc:HGNC:6654]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:10767331;11956245;1358758;15785774	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000136944#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10767331	$#ENSP00000347684#ENSG00000136944#ENST00000355497#Homeodomain#LIM$#ENSP00000362573#ENSG00000136944#ENST00000373474#Homeodomain#LIM$#ENSP00000436930#ENSG00000136944#ENST00000526117#Homeodomain#LIM$#ENSP00000453580#ENSG00000136944#ENST00000561065#Homeodomain#LIM	FALSE
1396	ENSG00000143995	MEIS1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	4211	Meis homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7000]	4XRM	DBD	Yes	None	MEIS1 homodimer	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12609849;16648484	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000143995#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000143995#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000272369#ENSG00000143995#ENST00000272369#Homeodomain#Meis_PKNOX_N$#ENSP00000475161#ENSG00000143995#ENST00000488550#Homeodomain#Meis_PKNOX_N$#ENSP00000440571#ENSG00000143995#ENST00000495021#Homeodomain#Meis_PKNOX_N	FALSE
1397	ENSG00000134138	MEIS2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	4212	Meis homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7001]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9811838;10764806	Yes	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000134138#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10764806$#ENSG00000134138#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10764806	$#ENSP00000341400#ENSG00000134138#ENST00000338564#Homeodomain#Meis_PKNOX_N$#ENSP00000339549#ENSG00000134138#ENST00000340545#Homeodomain#Meis_PKNOX_N$#ENSP00000404185#ENSG00000134138#ENST00000424352#Homeodomain#Meis_PKNOX_N$#ENSP00000453793#ENSG00000134138#ENST00000561208#Homeodomain#Meis_PKNOX_N$#ENSP00000380745#ENSG00000134138#ENST00000397620#Homeodomain#Meis_PKNOX_N$#ENSP00000453390#ENSG00000134138#ENST00000559085#Homeodomain#Meis_PKNOX_N$#ENSP00000452874#ENSG00000134138#ENST00000560617#Homeodomain#Meis_PKNOX_N$#ENSP00000475660#ENSG00000134138#ENST00000606653#Homeodomain#Meis_PKNOX_N$#ENSP00000475899#ENSG00000134138#ENST00000607277#Homeodomain#Meis_PKNOX_N	FALSE
1398	ENSG00000105419	MEIS3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	56917	Meis homeobox 3 [Source:HGNC Symbol;Acc:HGNC:29537]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000105419#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000388667#ENSG00000105419#ENST00000441740#Homeodomain#Meis_PKNOX_N$#ENSP00000453757#ENSG00000105419#ENST00000560245#Homeodomain#Meis_PKNOX_N$#ENSP00000453307#ENSG00000105419#ENST00000561293#Homeodomain#Meis_PKNOX_N$#ENSP00000476248#ENSG00000105419#ENST00000557833#Homeodomain#Meis_PKNOX_N$#ENSP00000452854#ENSG00000105419#ENST00000559524#Homeodomain#Meis_PKNOX_N$#ENSP00000453934#ENSG00000105419#ENST00000561096#Homeodomain#Meis_PKNOX_N$#ENSP00000475941#ENSG00000105419#ENST00000607695#Homeodomain#	FALSE
1399	ENSG00000005102	MEOX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	4222	mesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:15024065	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000005102#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000005102#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000321684#ENSG00000005102#ENST00000318579#Homeodomain#$#ENSP00000328678#ENSG00000005102#ENST00000329168#Homeodomain#$#ENSP00000449049#ENSG00000005102#ENST00000549132#Homeodomain#$#ENSP00000377271#ENSG00000005102#ENST00000393661#Homeodomain#	FALSE
1400	ENSG00000106511	MEOX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	4223	mesenchyme homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7014]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:16335786;17074759	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000106511#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17074759 | IMP - PMID:17074759$#ENSG00000106511#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:17074759 | IMP - PMID:17074759$#ENSG00000106511#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:22206000	$#ENSP00000262041#ENSG00000106511#ENST00000262041#Homeodomain#	FALSE
1401	ENSG00000185155	MIXL1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	83881	Mix paired-like homeobox [Source:HGNC Symbol;Acc:HGNC:13363]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; Transactivation_PMIDS:12117810	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000185155#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024, PMID:22164283$#ENSG00000185155#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#ISS - GO_REF:0000024, PMID:22164283	$#ENSP00000355775#ENSG00000185155#ENST00000366810#Homeodomain#$#ENSP00000442439#ENSG00000185155#ENST00000542034#Homeodomain#	FALSE
1402	ENSG00000150051	MKX	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Orthologous protein from fly is a TF that binds NWACA (PMID: 22923612).	IPR001356;IPR008422;IPR009057;IPR017970	283078	mohawk homeobox [Source:HGNC Symbol;Acc:HGNC:23729]	None	DBD and Full	not tested	None	PMID:22923612 for the B1H	b	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000364946#ENSG00000150051#ENST00000375790#Homeodomain#$#ENSP00000400896#ENSG00000150051#ENST00000419761#Homeodomain#$#ENSP00000452751#ENSG00000150051#ENST00000460919#Homeodomain#$#ENSP00000453746#ENSG00000150051#ENST00000561227#Homeodomain#	FALSE
1403	ENSG00000130675	MNX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3110	motor neuron and pancreas homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4979]	None	DBD	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000130675#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9843207	$#ENSP00000252971#ENSG00000130675#ENST00000252971#Homeodomain#$#ENSP00000416458#ENSG00000130675#ENST00000425745#Homeodomain#$#ENSP00000401158#ENSG00000130675#ENST00000428439#Homeodomain#$#ENSP00000475129#ENSG00000130675#ENST00000469500#Homeodomain#$#ENSP00000474286#ENSG00000130675#ENST00000479817#Homeodomain#$#ENSP00000438552#ENSG00000130675#ENST00000543409#Homeodomain#	FALSE
1404	ENSG00000163132	MSX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	4487	msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]	1IG7	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15192231;17030628	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000163132#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163132#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000163132#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000372170#ENSG00000163132#ENST00000382723#Homeodomain#	FALSE
1405	ENSG00000120149	MSX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	4488	msh homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7392]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:9368026;11798166;9265625;12750290	No	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000120149#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000120149#GO:0032792#negative regulation of CREB transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000239243#ENSG00000120149#ENST00000239243#Homeodomain#$#ENSP00000427425#ENSG00000120149#ENST00000507785#Homeodomain#	FALSE
1406	ENSG00000111704	NANOG	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	79923	Nanog homeobox [Source:HGNC Symbol;Acc:HGNC:20857]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000111704#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16153702	$#ENSP00000229307#ENSG00000111704#ENST00000229307#Homeodomain#$#ENSP00000435288#ENSG00000111704#ENST00000526286#Homeodomain#$#ENSP00000444434#ENSG00000111704#ENST00000541267#Homeodomain#	FALSE
1407	ENSG00000205857	NANOGNB	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR009057	360030	NANOG neighbor homeobox [Source:HGNC Symbol;Acc:HGNC:24958]	None	not tested	Yes	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000371553#ENSG00000205857#ENST00000382119#Homeodomain#	FALSE
1408	ENSG00000255192	NANOGP8	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	Listed as a pseudogene, but it encodes two protein products	IPR001356;IPR009057;IPR017970	None	Nanog homeobox pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:23106]	4RBO	Full	not tested	None	Crystal structure shows strong protein-protein interaction between the monomers	No	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12787504;15502159;15502159;16153702	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$##ENSG00000255192##Other#	FALSE
1409	ENSG00000235608	NKX1-1	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	54729	NK1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:24975]	None	not tested	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000407978#ENSG00000235608#ENST00000422806#Homeodomain#	FALSE
1410	ENSG00000229544	NKX1-2	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	390010	NK1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:31652]	None	not tested	not tested	None	None	No	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000451945#ENSG00000229544#ENST00000451024#Homeodomain#	FALSE
1411	ENSG00000136352	NKX2-1	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	7080	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1976511;11914369	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000136352#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16960125, PMID:7559607, PMID:7713914 | $#ENSG00000136352#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000346879#ENSG00000136352#ENST00000354822#Homeodomain#$#ENSP00000429607#ENSG00000136352#ENST00000498187#Homeodomain#$#ENSP00000429519#ENSG00000136352#ENST00000522719#Homeodomain#$#ENSP00000449302#ENSG00000136352#ENST00000546983#Homeodomain#	FALSE
1412	ENSG00000125820	NKX2-2	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	4821	NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000125820#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000125820#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000366347#ENSG00000125820#ENST00000377142#Homeodomain#	FALSE
1413	ENSG00000119919	NKX2-3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	159296	NK2 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:7836]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:10790368;12141427	No	1a1, Direct HQ evidence	Arttu Jolma	Tim Hughes	Yes	None	$#ENSP00000342828#ENSG00000119919#ENST00000344586#Homeodomain#$#ENSP00000479692#ENSG00000119919#ENST00000622383#Homeodomain#	FALSE
1414	ENSG00000125816	NKX2-4	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	644524	NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	None	$#ENSP00000345147#ENSG00000125816#ENST00000351817#Homeodomain#	FALSE
1415	ENSG00000183072	NKX2-5	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	1482	NK2 homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2488]	3RKQ	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:9584181;10318839	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000183072#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:15649947$#ENSG00000183072#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:19578358$#ENSG00000183072#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10948187, PMID:11431700, PMID:9312027, $#ENSG00000183072#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000327758#ENSG00000183072#ENST00000329198#Homeodomain#$#ENSP00000395378#ENSG00000183072#ENST00000424406#Homeodomain#$#ENSP00000427906#ENSG00000183072#ENST00000521848#Homeodomain#$#ENSP00000429905#ENSG00000183072#ENST00000517440#Homeodomain#	FALSE
1416	ENSG00000180053	NKX2-6	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	137814	NK2 homeobox 6 [Source:HGNC Symbol;Acc:HGNC:32940]	None	DBD	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:17263687	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000180053#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15649947	$#ENSP00000320089#ENSG00000180053#ENST00000325017#Homeodomain#	FALSE
1417	ENSG00000136327	NKX2-8	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	26257	NK2 homeobox 8 [Source:HGNC Symbol;Acc:HGNC:16364]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12167706	Yes	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000136327#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12167706$#ENSG00000136327#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9446603	$#ENSP00000258829#ENSG00000136327#ENST00000258829#Homeodomain#	FALSE
1418	ENSG00000167034	NKX3-1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	4824	NK3 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7838]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10993896	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000167034#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000167034#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:20855495 | NAS - PMID:11137288$#ENSG00000167034#GO:0004882#androgen receptor activity#IDA - PMID:19886863	$#ENSP00000370253#ENSG00000167034#ENST00000380871#Homeodomain#$#ENSP00000429729#ENSG00000167034#ENST00000523261#Homeodomain#	FALSE
1419	ENSG00000109705	NKX3-2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	579	NK3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:951]	None	DBD	not tested	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9256352;12746429	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000109705#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000371875#ENSG00000109705#ENST00000382438#Homeodomain#	FALSE
1420	ENSG00000163623	NKX6-1	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	4825	NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15883383	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000163623#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000163623#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000295886#ENSG00000163623#ENST00000295886#Homeodomain#$#ENSP00000449761#ENSG00000163623#ENST00000515820#Homeodomain#	FALSE
1421	ENSG00000148826	NKX6-2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	84504	NK6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:19321]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8096811	Yes	1a1, Direct HQ evidence	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000148826#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000148826#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11210186	$#ENSP00000357581#ENSG00000148826#ENST00000368592#Homeodomain#	FALSE
1422	ENSG00000165066	NKX6-3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	157848	NK6 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:26328]	None	DBD	Yes	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000429553#ENSG00000165066#ENST00000524115#Homeodomain#$#ENSP00000428361#ENSG00000165066#ENST00000518699#Homeodomain#	FALSE
1423	ENSG00000106410	NOBOX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057	135935	NOBOX oogenesis homeobox [Source:HGNC Symbol;Acc:HGNC:22448]	None	DBD	Yes	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:8096059	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000106410#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000419457#ENSG00000106410#ENST00000467773#Homeodomain#$#ENSP00000419565#ENSG00000106410#ENST00000483238#Homeodomain#	FALSE
1424	ENSG00000214513	NOTO	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057	344022	notochord homeobox [Source:HGNC Symbol;Acc:HGNC:31839]	None	DBD	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:7477317;15231714	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	None	$#ENSP00000381486#ENSG00000214513#ENST00000398468#Homeodomain#	FALSE
1425	ENSG00000171540	OTP	Homeodomain	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000047;IPR001356;IPR003654;IPR009057;IPR017970;	23440	orthopedia homeobox [Source:HGNC Symbol;Acc:HGNC:8518]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	None	$#ENSP00000302814#ENSG00000171540#ENST00000306422#Homeodomain#OAR	FALSE
1426	ENSG00000115507	OTX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003025;IPR003026;IPR009057;IPR013851;IPR017970	5013	orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Pratyush Das	Yes	$#ENSG00000115507#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:18849347	$#ENSP00000282549#ENSG00000115507#ENST00000282549#Homeodomain#TF_Otx$#ENSP00000355631#ENSG00000115507#ENST00000366671#Homeodomain#TF_Otx	FALSE
1427	ENSG00000165588	OTX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003022;IPR003025;IPR009057;IPR013851;IPR017970	5015	orthodenticle homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8522]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12559959;14625556	Yes	1a1, Direct HQ evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000165588#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12559959, PMID:20530484	$#ENSP00000343819#ENSG00000165588#ENST00000339475#Homeodomain#TF_Otx$#ENSP00000386185#ENSG00000165588#ENST00000408990#Homeodomain#TF_Otx$#ENSP00000474486#ENSG00000165588#ENST00000554788#Homeodomain#$#ENSP00000451357#ENSG00000165588#ENST00000554845#Homeodomain#TF_Otx$#ENSP00000452336#ENSG00000165588#ENST00000555006#Homeodomain#TF_Otx	FALSE
1428	ENSG00000185630	PBX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR005542;IPR009057;IPR017970	5087	PBX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8632]	1LFU	DBD and Full	Yes	Obligate_Multimer	Can bind weakly as a homodimer or monomer (structure is an NMR-model of monomer) but prefers heterodimers with HOX-proteins	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8183558;9315626;12529389	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000185630#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000185630#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10500199	$#ENSP00000356872#ENSG00000185630#ENST00000367897#Homeodomain#PBC$#ENSP00000405890#ENSG00000185630#ENST00000420696#Homeodomain#PBC$#ENSP00000439943#ENSG00000185630#ENST00000540236#Homeodomain#PBC$#ENSP00000473998#ENSG00000185630#ENST00000485769#Homeodomain#PBC$#ENSP00000485692#ENSG00000185630#ENST00000627490#Homeodomain#PBC	FALSE
1429	ENSG00000204304	PBX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	High sequence similarity to PBX1, PBX4, and drosophila exd, which have in vitro-derived motifs	IPR001356;IPR005542;IPR009057;IPR017970	5089	PBX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8633]	None	Full	not tested	Obligate_Multimer	Obligate heterodimer with e.g.  Classical homeodomains	a	Yes	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000364190#ENSG00000204304#ENST00000375050#Homeodomain#PBC	FALSE
1430	ENSG00000167081	PBX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	High sequence similarity to PBX1, PBX4, and drosophila exd, which have in vitro-derived motifs	IPR001356;IPR005542;IPR008422;IPR009057;IPR017970;	5090	PBX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:8634]	None	DBD and Full	not tested	Obligate_Multimer	Obligate heterodimer with e.g.  Classical homeodomains	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15466398	No	2a1, Lower confidence direct evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000167081#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000362588#ENSG00000167081#ENST00000373489#Homeodomain#PBC$#ENSP00000387456#ENSG00000167081#ENST00000447726#Homeodomain#PBC	FALSE
1431	ENSG00000105717	PBX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR005542;IPR009057;	80714	PBX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:13403]	None	DBD and Full	not tested	Obligate_Multimer	Obligate heterodimer with e.g.  Classical homeodomains	b	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10679934;11262231;11335119	No	2a1, Lower confidence direct evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000105717#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000251203#ENSG00000105717#ENST00000251203#Homeodomain#PBC	FALSE
1432	ENSG00000139515	PDX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR017995;IPR020479;	3651	pancreatic and duodenal homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6107]	2H1K	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14704343	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000139515#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:17941991$#ENSG00000139515#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000370421#ENSG00000139515#ENST00000381033#Homeodomain#	FALSE
1433	ENSG00000165462	PHOX2A	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	401	paired like homeobox 2a [Source:HGNC Symbol;Acc:HGNC:691]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11034547	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000165462#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8661014	$#ENSP00000298231#ENSG00000165462#ENST00000298231#Homeodomain#$#ENSP00000444845#ENSG00000165462#ENST00000546310#Homeodomain#	FALSE
1434	ENSG00000109132	PHOX2B	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	8929	paired like homeobox 2b [Source:HGNC Symbol;Acc:HGNC:9143]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11752063;16280598	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000109132#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16144830	$#ENSP00000226382#ENSG00000109132#ENST00000226382#Homeodomain#	FALSE
1435	ENSG00000069011	PITX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR016233;IPR017970;IPR020479	5307	paired like homeodomain 1 [Source:HGNC Symbol;Acc:HGNC:9004]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11328855;15226417	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000069011#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000069011#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000265340#ENSG00000069011#ENST00000265340#Homeodomain#OAR$#ENSP00000427542#ENSG00000069011#ENST00000506438#Homeodomain#OAR$#ENSP00000423624#ENSG00000069011#ENST00000502676#Homeodomain#$#ENSP00000451199#ENSG00000069011#ENST00000503586#Homeodomain#$#ENSP00000422908#ENSG00000069011#ENST00000507253#Homeodomain#	FALSE
1436	ENSG00000164093	PITX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR016233;IPR017970;IPR020479	5308	paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005]	2LKX	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:15728254	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000164093#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000164093#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15385555	$#ENSP00000304169#ENSG00000164093#ENST00000306732#Homeodomain#OAR$#ENSP00000347192#ENSG00000164093#ENST00000355080#Homeodomain#OAR$#ENSP00000378097#ENSG00000164093#ENST00000394598#Homeodomain#OAR$#ENSP00000347004#ENSG00000164093#ENST00000354925#Homeodomain#OAR$#ENSP00000475617#ENSG00000164093#ENST00000557119#Homeodomain#$#ENSP00000424142#ENSG00000164093#ENST00000511990#Homeodomain#	FALSE
1437	ENSG00000107859	PITX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR016233;IPR017970;	5309	paired like homeodomain 3 [Source:HGNC Symbol;Acc:HGNC:9006]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11299318	No	1a1, Direct HQ evidence	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000107859#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000359019#ENSG00000107859#ENST00000370002#Homeodomain#OAR$#ENSP00000439383#ENSG00000107859#ENST00000539804#Homeodomain#OAR	FALSE
1438	ENSG00000160199	PKNOX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	5316	PBX/knotted 1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9022]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9482739;10869353	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000160199#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000160199#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9143494$#ENSG00000160199#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000291547#ENSG00000160199#ENST00000291547#Homeodomain#Meis_PKNOX_N$#ENSP00000402243#ENSG00000160199#ENST00000432907#Homeodomain#Meis_PKNOX_N	FALSE
1439	ENSG00000165495	PKNOX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	63876	PBX/knotted 1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:16714]	None	DBD	Yes	None	None	b	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11972344;15339927	No	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	None	$#ENSP00000298282#ENSG00000165495#ENST00000298282#Homeodomain#Meis_PKNOX_N$#ENSP00000431599#ENSG00000165495#ENST00000527238#Homeodomain#$#ENSP00000434255#ENSG00000165495#ENST00000531212#Homeodomain#$#ENSP00000453374#ENSG00000165495#ENST00000558705#Homeodomain#	FALSE
1440	ENSG00000175325	PROP1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970	5626	PROP paired-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9455]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:10199788;11064154	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000175325#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000175325#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000311290#ENSG00000175325#ENST00000308304#Homeodomain#	FALSE
1441	ENSG00000116132	PRRX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	5396	paired related homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9142]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9334314	No	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	None	$#ENSP00000239461#ENSG00000116132#ENST00000239461#Homeodomain#OAR$#ENSP00000356734#ENSG00000116132#ENST00000367760#Homeodomain#$#ENSP00000450762#ENSG00000116132#ENST00000497230#Homeodomain#	FALSE
1442	ENSG00000167157	PRRX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	51450	paired related homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21338]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7901837	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000167157#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11063257	$#ENSP00000361547#ENSG00000167157#ENST00000372469#Homeodomain#OAR	FALSE
1443	ENSG00000134438	RAX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970	30062	retina and anterior neural fold homeobox [Source:HGNC Symbol;Acc:HGNC:18662]	None	DBD	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11069920;10625658;10625658;10625658;10625658;11069920	Yes	1a1, Direct HQ evidence	Matt Weirauch	Tim Hughes	Yes	$#ENSG00000134438#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10625658	$#ENSP00000256852#ENSG00000134438#ENST00000256852#Homeodomain#$#ENSP00000334813#ENSG00000134438#ENST00000334889#Homeodomain#OAR$#ENSP00000450583#ENSG00000134438#ENST00000555288#Homeodomain#	FALSE
1444	ENSG00000173976	RAX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	84839	retina and anterior neural fold homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18286]	None	DBD	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000450456#ENSG00000173976#ENST00000555633#Homeodomain#$#ENSP00000450687#ENSG00000173976#ENST00000555978#Homeodomain#	FALSE
1445	ENSG00000101883	RHOXF1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970	158800	Rhox homeobox family member 1 [Source:HGNC Symbol;Acc:HGNC:29993]	None	DBD and Full	not tested	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Tim Hughes	Yes	$#ENSG00000101883#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:12490318	$#ENSP00000217999#ENSG00000101883#ENST00000217999#Homeodomain#	FALSE
1446	ENSG00000131721	RHOXF2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	84528	Rhox homeobox family member 2 [Source:HGNC Symbol;Acc:HGNC:30011]	None	DBD and Full	not tested	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	None	$#ENSP00000360441#ENSG00000131721#ENST00000371388#Homeodomain#	FALSE
1447	ENSG00000203989	RHOXF2B	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	727940	Rhox homeobox family member 2B [Source:HGNC Symbol;Acc:HGNC:33519]	None	DBD	Yes	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000360455#ENSG00000203989#ENST00000371402#Homeodomain#	FALSE
1448	ENSG00000274529	SEBOX	Homeodomain	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	Role in early development (PMID: 24018616).	IPR001356;IPR009057	645832	SEBOX homeobox [Source:HGNC Symbol;Acc:HGNC:32942]	None	DBD	Yes	None	PMID:24018616 seems like a real homeobox with role in early development	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000444503#ENSG00000274529#ENST00000536498#Homeodomain#	FALSE
1449	ENSG00000185960	SHOX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR003654;IPR009057;IPR017970;	6473	short stature homeobox [Source:HGNC Symbol;Acc:HGNC:10853]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000185960#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9259282	$#ENSP00000370987#ENSG00000185960#ENST00000381575#Homeodomain#$#ENSP00000452016#ENSG00000185960#ENST00000554971#Homeodomain#OAR$#ENSP00000335505#ENSG00000185960#ENST00000334060#Homeodomain#$#ENSP00000370990#ENSG00000185960#ENST00000381578#Homeodomain#OAR	FALSE
1450	ENSG00000168779	SHOX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR003654;IPR009057;IPR017970;	6474	short stature homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10854]	None	DBD and Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	None	$#ENSP00000374240#ENSG00000168779#ENST00000389589#Homeodomain#OAR$#ENSP00000419362#ENSG00000168779#ENST00000483851#Homeodomain#OAR	FALSE
1451	ENSG00000126778	SIX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	6495	SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9826681	Yes	1a1, Direct HQ evidence	Tim Hughes	Arttu Jolma	Yes	$#ENSG00000126778#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15141091 | IMP - PMID:15141091$#ENSG00000126778#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19497856 | ISS - GO_REF:0000024	$#ENSP00000247182#ENSG00000126778#ENST00000247182#Homeodomain#SIX1_SD$#ENSP00000452700#ENSG00000126778#ENST00000554986#Homeodomain#	FALSE
1452	ENSG00000170577	SIX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	10736	SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15327782	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000170577#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000170577#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10773454	$#ENSP00000304502#ENSG00000170577#ENST00000303077#Homeodomain#SIX1_SD	FALSE
1453	ENSG00000138083	SIX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057	6496	SIX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:10889]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:12543801	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000138083#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000138083#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000260653#ENSG00000138083#ENST00000260653#Homeodomain#SIX1_SD	FALSE
1454	ENSG00000100625	SIX4	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	51804	SIX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:10890]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14966291	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000100625#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000216513#ENSG00000100625#ENST00000216513#Homeodomain#SIX1_SD$#ENSP00000450761#ENSG00000100625#ENST00000556952#Homeodomain#SIX1_SD	FALSE
1455	ENSG00000177045	SIX5	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001356;IPR009057;IPR017970;	147912	SIX homeobox 5 [Source:HGNC Symbol;Acc:HGNC:10891]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000316842#ENSG00000177045#ENST00000317578#Homeodomain#SIX1_SD$#ENSP00000453239#ENSG00000177045#ENST00000560160#Homeodomain#SIX1_SD$#ENSP00000453189#ENSG00000177045#ENST00000560168#Homeodomain#$#ENSP00000481365#ENSG00000177045#ENST00000622857#Homeodomain#	FALSE
1456	ENSG00000184302	SIX6	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057	4990	SIX homeobox 6 [Source:HGNC Symbol;Acc:HGNC:10892]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000184302#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000328596#ENSG00000184302#ENST00000327720#Homeodomain#SIX1_SD	FALSE
1457	ENSG00000177426	TGIF1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	7050	TGFB induced factor homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11776]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8537382	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000177426#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10764806 | IMP - PMID:10764806$#ENSG00000177426#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8537382	$#ENSP00000327959#ENSG00000177426#ENST00000330513#Homeodomain#$#ENSP00000339631#ENSG00000177426#ENST00000343820#Homeodomain#$#ENSP00000385206#ENSG00000177426#ENST00000401449#Homeodomain#$#ENSP00000384970#ENSG00000177426#ENST00000405385#Homeodomain#$#ENSP00000449501#ENSG00000177426#ENST00000472042#Homeodomain#$#ENSP00000446944#ENSG00000177426#ENST00000551402#Homeodomain#$#ENSP00000450025#ENSG00000177426#ENST00000551541#Homeodomain#$#ENSP00000449287#ENSG00000177426#ENST00000552383#Homeodomain#$#ENSP00000483499#ENSG00000177426#ENST00000618001#Homeodomain#$#ENSP00000343969#ENSG00000177426#ENST00000345133#Homeodomain#$#ENSP00000383031#ENSG00000177426#ENST00000400167#Homeodomain#$#ENSP00000384133#ENSG00000177426#ENST00000407501#Homeodomain#$#ENSP00000448934#ENSG00000177426#ENST00000546979#Homeodomain#$#ENSP00000447747#ENSG00000177426#ENST00000548489#Homeodomain#$#ENSP00000449973#ENSG00000177426#ENST00000549253#Homeodomain#$#ENSP00000449722#ENSG00000177426#ENST00000549468#Homeodomain#$#ENSP00000449531#ENSG00000177426#ENST00000550958#Homeodomain#$#ENSP00000446838#ENSG00000177426#ENST00000551333#Homeodomain#$#ENSP00000462285#ENSG00000177426#ENST00000577543#Homeodomain#	FALSE
1458	ENSG00000118707	TGIF2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	60436	TGFB induced factor homeobox 2 [Source:HGNC Symbol;Acc:HGNC:15764]	None	DBD	Yes	None	None	x	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000118707#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11006116	$#ENSP00000362979#ENSG00000118707#ENST00000373872#Homeodomain#$#ENSP00000362981#ENSG00000118707#ENST00000373874#Homeodomain#$#ENSP00000476174#ENSG00000118707#ENST00000557885#Homeodomain#$#ENSP00000452878#ENSG00000118707#ENST00000558028#Homeodomain#$#ENSP00000481787#ENSG00000118707#ENST00000611732#Homeodomain#$#ENSP00000475479#ENSG00000118707#ENST00000558465#Homeodomain#$#ENSP00000453773#ENSG00000118707#ENST00000560025#Homeodomain#$#ENSP00000475729#ENSG00000118707#ENST00000561398#Homeodomain#Homeobox_KN	FALSE
1459	ENSG00000153779	TGIF2LX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	90316	TGFB induced factor homeobox 2 like, X-linked [Source:HGNC Symbol;Acc:HGNC:18570]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000355119#ENSG00000153779#ENST00000283891#Homeodomain#$#ENSP00000453704#ENSG00000153779#ENST00000561129#Homeodomain#	FALSE
1460	ENSG00000176679	TGIF2LY	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR008422;IPR009057;	90655	TGFB induced factor homeobox 2 like, Y-linked [Source:HGNC Symbol;Acc:HGNC:18569]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000318502#ENSG00000176679#ENST00000321217#Homeodomain#$#ENSP00000453750#ENSG00000176679#ENST00000559055#Homeodomain#	FALSE
1461	ENSG00000107807	TLX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001356;IPR009057;IPR017970;IPR020479	3195	T-cell leukemia homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5056]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15944191	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Jussi Taipale	Yes	None	$#ENSP00000359215#ENSG00000107807#ENST00000370196#Homeodomain#$#ENSP00000434914#ENSG00000107807#ENST00000467928#Homeodomain#$#ENSP00000434358#ENSG00000107807#ENST00000463716#Homeodomain#	FALSE
1462	ENSG00000115297	TLX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	3196	T-cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5057]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10869550	No	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	None	$#ENSP00000233638#ENSG00000115297#ENST00000233638#Homeodomain#$#ENSP00000482690#ENSG00000115297#ENST00000621092#Homeodomain#	FALSE
1463	ENSG00000164438	TLX3	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR020479	30012	T-cell leukemia homeobox 3 [Source:HGNC Symbol;Acc:HGNC:13532]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000296921#ENSG00000164438#ENST00000296921#Homeodomain#	FALSE
1464	ENSG00000178928	TPRX1	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Expressed in early embryo as transcripts that contain a full homeodomain (PMID: 27412763).	IPR001356;IPR009057;IPR017970;	284355	tetra-peptide repeat homeobox 1 [Source:HGNC Symbol;Acc:HGNC:32174]	None	DBD and Full	not tested	None	PMID:27412763 Expressed in early embryo as transcripts that contain a full homeodomain	b	Yes	No	No	3a, decent circumstantial evidence for its role as	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000323455#ENSG00000178928#ENST00000322175#Homeodomain#$#ENSP00000438832#ENSG00000178928#ENST00000535759#Homeodomain#$#ENSP00000438712#ENSG00000178928#ENST00000543508#Homeodomain#	FALSE
1465	ENSG00000164853	UNCX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	340260	UNC homeobox [Source:HGNC Symbol;Acc:HGNC:33194]	None	DBD	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	None	$#ENSP00000314480#ENSG00000164853#ENST00000316333#Homeodomain#	FALSE
1466	ENSG00000148704	VAX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970	11023	ventral anterior homeobox 1 [Source:HGNC Symbol;Acc:HGNC:12660]	None	DBD	Yes	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15322073	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000148704#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000277905#ENSG00000148704#ENST00000277905#Homeodomain#$#ENSP00000358207#ENSG00000148704#ENST00000369206#Homeodomain#	FALSE
1467	ENSG00000116035	VAX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000047;IPR001356;IPR009057;IPR017970;IPR020479;	25806	ventral anterior homeobox 2 [Source:HGNC Symbol;Acc:HGNC:12661]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000116035#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000116035#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10485894	$#ENSP00000234392#ENSG00000116035#ENST00000234392#Homeodomain#	FALSE
1468	ENSG00000151650	VENTX	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;	27287	VENT homeobox [Source:HGNC Symbol;Acc:HGNC:13639]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	None	$#ENSP00000357556#ENSG00000151650#ENST00000325980#Homeodomain#	FALSE
1469	ENSG00000100987	VSX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR009057;IPR017970;IPR023339	30813	visual system homeobox 1 [Source:HGNC Symbol;Acc:HGNC:12723]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11978762;15647262	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000100987#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10673340	$#ENSP00000365897#ENSG00000100987#ENST00000376707#Homeodomain#$#ENSP00000365899#ENSG00000100987#ENST00000376709#Homeodomain#$#ENSP00000401690#ENSG00000100987#ENST00000429762#Homeodomain#$#ENSP00000387720#ENSG00000100987#ENST00000444511#Homeodomain#	FALSE
1470	ENSG00000119614	VSX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003654;IPR009057;IPR017970;IPR023339;	338917	visual system homeobox 2 [Source:HGNC Symbol;Acc:HGNC:1975]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10903837;15647262	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	None	$#ENSP00000261980#ENSG00000119614#ENST00000261980#Homeodomain#OAR	FALSE
1471	ENSG00000136367	ZFHX2	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR003604;IPR007087;IPR009057;IPR015880;IPR017970	85446	zinc finger homeobox 2 [Source:HGNC Symbol;Acc:HGNC:20152]	None	not tested	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000409464#ENSG00000136367#ENST00000412565#Homeodomain#$#ENSP00000478696#ENSG00000136367#ENST00000615307#Homeodomain#$#ENSP00000413418#ENSG00000136367#ENST00000419474#Homeodomain#zf-C2H2_2, zf-H2C2_5, zf-met$#ENSP00000451342#ENSG00000136367#ENST00000555334#Homeodomain#	FALSE
1472	ENSG00000165156	ZHX1	Homeodomain	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001356;IPR007087;IPR009057;IPR015880;IPR024578;	11244	zinc fingers and homeoboxes 1 [Source:HGNC Symbol;Acc:HGNC:12871]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12237128	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000165156#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12237128	$#ENSP00000378938#ENSG00000165156#ENST00000395571#Homeodomain#$#ENSP00000428821#ENSG00000165156#ENST00000522655#Homeodomain#$#ENSP00000297857#ENSG00000165156#ENST00000297857#Homeodomain#$#ENSP00000475324#ENSG00000165156#ENST00000602651#Homeodomain#	FALSE
1473	ENSG00000178764	ZHX2	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR007087;IPR009057;IPR015880	22882	zinc fingers and homeoboxes 2 [Source:HGNC Symbol;Acc:HGNC:18513]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_TF PPI; Transactivation_PMIDS:12741956;14659886	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000178764#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12741956	$#ENSP00000314709#ENSG00000178764#ENST00000314393#Homeodomain#DUF3505, Homez$#ENSP00000452720#ENSG00000178764#ENST00000534247#Homeodomain#	FALSE
1474	ENSG00000174306	ZHX3	Homeodomain	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR001356;IPR009057;IPR015880;IPR024578	23051	zinc fingers and homeoboxes 3 [Source:HGNC Symbol;Acc:HGNC:15935]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000174306#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12659632	$#ENSP00000405421#ENSG00000174306#ENST00000421422#Homeodomain#$#ENSP00000443783#ENSG00000174306#ENST00000544979#Homeodomain#Homez$#ENSP00000452965#ENSG00000174306#ENST00000559234#Homeodomain#$#ENSP00000454006#ENSG00000174306#ENST00000560361#Homeodomain#$#ENSP00000362358#ENSG00000174306#ENST00000373261#Homeodomain#$#ENSP00000415498#ENSG00000174306#ENST00000432768#Homeodomain#$#ENSP00000401852#ENSG00000174306#ENST00000436099#Homeodomain#$#ENSP00000399433#ENSG00000174306#ENST00000441102#Homeodomain#zf-Di19$#ENSP00000453310#ENSG00000174306#ENST00000559436#Homeodomain#Homez$#ENSP00000403048#ENSG00000174306#ENST00000436440#Homeodomain#	FALSE
1475	ENSG00000075891	PAX2	Homeodomain; Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001523;IPR009057;IPR022130;	5076	paired box 2 [Source:HGNC Symbol;Acc:HGNC:8616]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:11700324;11731455;14561758;12756174	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	None	$#ENSP00000347385#ENSG00000075891#ENST00000355243#Homeodomain,Paired box#Pax2_C$#ENSP00000359319#ENSG00000075891#ENST00000370296#Homeodomain,Paired box#Pax2_C$#ENSP00000452489#ENSG00000075891#ENST00000554172#Homeodomain,Paired box#$#ENSP00000355069#ENSG00000075891#ENST00000361791#Homeodomain,Paired box#Pax2_C$#ENSP00000398652#ENSG00000075891#ENST00000427256#Homeodomain,Paired box#	FALSE
1476	ENSG00000135903	PAX3	Homeodomain; Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001523;IPR009057;IPR017970;IPR022106;	5077	paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617]	3CMY	DBD and Full	not tested	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16945326	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000135903#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000258387#ENSG00000135903#ENST00000258387#Homeodomain,Paired box#$#ENSP00000338767#ENSG00000135903#ENST00000336840#Homeodomain,Paired box#Pax7$#ENSP00000342092#ENSG00000135903#ENST00000344493#Homeodomain,Paired box#Pax7$#ENSP00000375922#ENSG00000135903#ENST00000392070#Homeodomain,Paired box#Pax7$#ENSP00000386750#ENSG00000135903#ENST00000409551#Homeodomain,Paired box#Pax7$#ENSP00000386817#ENSG00000135903#ENST00000409828#Homeodomain,Paired box#	FALSE
1477	ENSG00000106331	PAX4	Homeodomain; Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001523;IPR009057;IPR017970	5078	paired box 4 [Source:HGNC Symbol;Acc:HGNC:8618]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10567553	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000106331#GO:0001206#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$#ENSP00000339906#ENSG00000106331#ENST00000341640#Homeodomain,Paired box#$#ENSP00000368014#ENSG00000106331#ENST00000378740#Homeodomain,Paired box#$#ENSP00000451923#ENSG00000106331#ENST00000463946#Homeodomain,Paired box#	FALSE
1478	ENSG00000007372	PAX6	Homeodomain; Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001523;IPR009057;IPR017970	5080	paired box 6 [Source:HGNC Symbol;Acc:HGNC:8620]	6PAX	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7753864;7841787;8132558;9710641;12756174	Yes	1a1, Direct HQ evidence	Jussi Taipale	Yimeng Yin	Yes	$#ENSG00000007372#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:20592023$#ENSG00000007372#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000007372#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000007372#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10441571, PMID:10747901	$#ENSP00000241001#ENSG00000007372#ENST00000241001#Homeodomain,Paired box#$#ENSP00000368406#ENSG00000007372#ENST00000379111#Homeodomain,Paired box#$#ENSP00000368410#ENSG00000007372#ENST00000379115#Homeodomain,Paired box#$#ENSP00000368418#ENSG00000007372#ENST00000379123#Homeodomain,Paired box#$#ENSP00000404100#ENSG00000007372#ENST00000419022#Homeodomain,Paired box#$#ENSP00000480026#ENSG00000007372#ENST00000606377#Homeodomain,Paired box#$#ENSP00000368403#ENSG00000007372#ENST00000379109#Homeodomain,Paired box#$#ENSP00000404356#ENSG00000007372#ENST00000438681#Homeodomain,Paired box#$#ENSP00000388132#ENSG00000007372#ENST00000423822#Homeodomain,Paired box#$#ENSP00000436365#ENSG00000007372#ENST00000525535#Homeodomain,Paired box#	FALSE
1479	ENSG00000009709	PAX7	Homeodomain; Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001356;IPR001523;IPR009057;IPR017970;IPR022106;	5081	paired box 7 [Source:HGNC Symbol;Acc:HGNC:8621]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding; Transactivation_PMIDS:15688409	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000009709#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000009709#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9339373	$#ENSP00000364524#ENSG00000009709#ENST00000375375#Homeodomain,Paired box#Pax7$#ENSP00000383502#ENSG00000009709#ENST00000400661#Homeodomain,Paired box#Pax7$#ENSP00000403389#ENSG00000009709#ENST00000420770#Homeodomain,Paired box#Pax7	FALSE
1480	ENSG00000064835	POU1F1	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970	5449	POU class 1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9210]	1AU7	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000064835#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:26612202$#ENSG00000064835#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000064835#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11301317, PMID:9482665	$#ENSP00000263781#ENSG00000064835#ENST00000350375#Homeodomain,POU#$#ENSP00000342931#ENSG00000064835#ENST00000344265#Homeodomain,POU#$#ENSP00000452610#ENSG00000064835#ENST00000560656#Homeodomain,POU#$#ENSP00000454072#ENSG00000064835#ENST00000561167#Homeodomain,POU#	FALSE
1481	ENSG00000143190	POU2F1	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR000972;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970;	5451	POU class 2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9212]	1E3O	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1980478	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000143190#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000356836#ENSG00000143190#ENST00000367862#Homeodomain,POU#$#ENSP00000356840#ENSG00000143190#ENST00000367866#Homeodomain,POU#$#ENSP00000415993#ENSG00000143190#ENST00000443275#Homeodomain,POU#$#ENSP00000441285#ENSG00000143190#ENST00000541643#Homeodomain,POU#$#ENSP00000401217#ENSG00000143190#ENST00000429375#Homeodomain,POU#	FALSE
1482	ENSG00000028277	POU2F2	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR000972;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970;	5452	POU class 2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9213]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2904653	Yes	1a1, Direct HQ evidence	Sam Lambert	Tim Hughes	Yes	$#ENSG00000028277#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000028277#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9442393	$#ENSP00000373992#ENSG00000028277#ENST00000389341#Homeodomain,POU#$#ENSP00000431603#ENSG00000028277#ENST00000526816#Homeodomain,POU#$#ENSP00000437224#ENSG00000028277#ENST00000529067#Homeodomain,POU#$#ENSP00000436988#ENSG00000028277#ENST00000529952#Homeodomain,POU#$#ENSP00000490407#ENSG00000028277#ENST00000524801#Homeodomain,POU#DUF755$#ENSP00000476062#ENSG00000028277#ENST00000526831#Homeodomain,POU#AF-4$#ENSP00000475664#ENSG00000028277#ENST00000528894#Homeodomain,POU#$#ENSP00000490838#ENSG00000028277#ENST00000532176#Homeodomain,POU#$#ENSP00000453995#ENSG00000028277#ENST00000533548#Homeodomain,POU#$#ENSP00000471890#ENSG00000028277#ENST00000598842#Homeodomain,POU#$#ENSP00000490243#ENSG00000028277#ENST00000636631#Homeodomain,POU#	FALSE
1483	ENSG00000137709	POU2F3	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR000972;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970;	25833	POU class 2 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:19864]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000137709#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12624109 | IMP - PMID:12624109	$#ENSP00000441687#ENSG00000137709#ENST00000543440#Homeodomain,POU#$#ENSP00000260264#ENSG00000137709#ENST00000260264#Homeodomain,POU#$#ENSP00000453150#ENSG00000137709#ENST00000532663#Homeodomain,POU#	FALSE
1484	ENSG00000185668	POU3F1	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970;	5453	POU class 3 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9214]	2XSD	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1705013;1979677	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000185668#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000362103#ENSG00000185668#ENST00000373012#Homeodomain,POU#	FALSE
1485	ENSG00000184486	POU3F2	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970;	5454	POU class 3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9215]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15262984	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000184486#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000184486#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7601453, PMID:9482665	$#ENSP00000329170#ENSG00000184486#ENST00000328345#Homeodomain,POU#DUF2722	FALSE
1486	ENSG00000198914	POU3F3	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970;	5455	POU class 3 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:9216]	None	DBD	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000198914#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000355001#ENSG00000198914#ENST00000361360#Homeodomain,POU#	FALSE
1487	ENSG00000196767	POU3F4	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR016362;IPR017970;	5456	POU class 3 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:9217]	None	DBD	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000196767#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000362296#ENSG00000196767#ENST00000373200#Homeodomain,POU#	FALSE
1488	ENSG00000152192	POU4F1	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970	5457	POU class 4 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9218]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12810599	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000152192#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:23805044$#ENSG00000152192#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000152192#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000152192#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000366413#ENSG00000152192#ENST00000377208#Homeodomain,POU#	FALSE
1489	ENSG00000151615	POU4F2	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970	5458	POU class 4 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9219]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000151615#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:23805044$#ENSG00000151615#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17637757, PMID:21241485$#ENSG00000151615#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024	$#ENSP00000281321#ENSG00000151615#ENST00000281321#Homeodomain,POU#	FALSE
1490	ENSG00000091010	POU4F3	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970	5459	POU class 4 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:9220]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15465029	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000091010#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15465029$#ENSG00000091010#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:23805044$#ENSG00000091010#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9506947	$#ENSP00000230732#ENSG00000091010#ENST00000230732#Homeodomain,POU#	FALSE
1491	ENSG00000204531	POU5F1	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970	5460	POU class 5 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9221]	3L1P	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12615074	No	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000204531#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - GO_REF:0000024$#ENSG00000204531#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:19409607$#ENSG00000204531#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16153702	$#ENSP00000259915#ENSG00000204531#ENST00000259915#Homeodomain,POU#$#ENSP00000389359#ENSG00000204531#ENST00000441888#Homeodomain,POU#$#ENSP00000425083#ENSG00000204531#ENST00000471529#Homeodomain,POU#$#ENSP00000425479#ENSG00000204531#ENST00000512818#Homeodomain,POU#$#ENSP00000475512#ENSG00000204531#ENST00000513407#Homeodomain,POU#$#ENSP00000475880#ENSG00000204531#ENST00000606567#Homeodomain,POU#$#ENSP00000484778#ENSG00000204531#ENST00000620031#Homeodomain,POU#	FALSE
1492	ENSG00000212993	POU5F1B	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;IPR017970	5462	POU class 5 homeobox 1B [Source:HGNC Symbol;Acc:HGNC:9223]	None	DBD	not tested	None	Cell paper uses outdated symbol POU5F1P1, gene is not annotated as a pseudogene in the new version of Ensembl	c	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000212993#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1408763	$#ENSP00000419298#ENSG00000212993#ENST00000465342#Homeodomain,POU#	FALSE
1493	ENSG00000248483	POU5F2	Homeodomain; POU	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847	134187	POU domain class 5, transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:26367]	None	not tested	not tested	None	Expressed in testis, contains both the POU and homeodomains	No	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000248483#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000489796#ENSG00000248483#ENST00000606183#Homeodomain,POU#	FALSE
1494	ENSG00000184271	POU6F1	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;	5463	POU class 6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9224]	3D1N	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:8645295	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000184271#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000330190#ENSG00000184271#ENST00000333640#Homeodomain,POU#$#ENSP00000448389#ENSG00000184271#ENST00000550824#Homeodomain,POU#$#ENSP00000373895#ENSG00000184271#ENST00000389243#Homeodomain,POU#$#ENSP00000490559#ENSG00000184271#ENST00000552305#Homeodomain,POU#	FALSE
1495	ENSG00000106536	POU6F2	Homeodomain; POU	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000327;IPR001356;IPR009057;IPR010982;IPR013847;	11281	POU class 6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21694]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Tim Hughes	Yes	$#ENSG00000106536#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8601806	$#ENSP00000430514#ENSG00000106536#ENST00000518318#Homeodomain,POU#$#ENSP00000409684#ENSG00000106536#ENST00000451021#Homeodomain,POU#	FALSE
1496	ENSG00000185122	HSF1	HSF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000232;IPR010542	3297	heat shock transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5224]	5D5U	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9545528	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000185122#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8926278$#ENSG00000185122#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10821850, PMID:1871105	$#ENSP00000431512#ENSG00000185122#ENST00000528838#HSF#Vert_HS_TF$#ENSP00000383590#ENSG00000185122#ENST00000400780#HSF#Vert_HS_TF$#ENSP00000436616#ENSG00000185122#ENST00000533240#HSF#HMMR_C, ZapB	FALSE
1497	ENSG00000025156	HSF2	HSF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000232;IPR010542	3298	heat shock transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:5225]	5D8K	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000025156#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:10561509$#ENSG00000025156#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1871106	$#ENSP00000357440#ENSG00000025156#ENST00000368455#HSF#Vert_HS_TF$#ENSP00000400380#ENSG00000025156#ENST00000452194#HSF#Vert_HS_TF$#ENSP00000477405#ENSG00000025156#ENST00000465214#HSF#Vert_HS_TF	FALSE
1498	ENSG00000102878	HSF4	HSF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000232;	3299	heat shock transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:5227]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:8972228;10488131;11278480	Yes	1a1, Direct HQ evidence	Yimeng Yin	Tim Hughes	Yes	$#ENSG00000102878#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000430947#ENSG00000102878#ENST00000521374#HSF#Vert_HS_TF$#ENSP00000463706#ENSG00000102878#ENST00000584272#HSF#$#ENSP00000428077#ENSG00000102878#ENST00000519601#HSF#$#ENSP00000429486#ENSG00000102878#ENST00000521916#HSF#	FALSE
1499	ENSG00000176160	HSF5	HSF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000232;	124535	Heat shock transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:26862]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000176160#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000313243#ENSG00000176160#ENST00000323777#HSF#$#ENSP00000484295#ENSG00000176160#ENST00000617946#HSF#	FALSE
1500	ENSG00000171116	HSFX1	HSF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000232;	100506164	heat shock transcription factor family, X-linked 1 [Source:HGNC Symbol;Acc:HGNC:29603]	None	DBD	not tested	None	Y chromosome homolg binds DNA	x	Yes	No	No	3a, decent circumstantial evidence for its role as	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000171116#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000359444#ENSG00000171116#ENST00000370416#HSF#	FALSE
1501	ENSG00000268738	HSFX2	HSF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000232;	100130086	heat shock transcription factor family, X-linked 2 [Source:HGNC Symbol;Acc:HGNC:32701]	None	not tested	not tested	None	Y chromosome homolg binds DNA	x	Yes	No	No	3a, decent circumstantial evidence for its role as	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000469223#ENSG00000268738#ENST00000598963#HSF#	FALSE
1502	ENSG00000172468	HSFY1	HSF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000232;	159119	heat shock transcription factor, Y-linked 1 [Source:HGNC Symbol;Acc:HGNC:18568]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000172468#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000303599#ENSG00000172468#ENST00000307393#HSF#$#ENSP00000311166#ENSG00000172468#ENST00000309834#HSF#$#ENSP00000372307#ENSG00000172468#ENST00000382856#HSF#	FALSE
1503	ENSG00000169953	HSFY2	HSF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000232;	159119	heat shock transcription factor, Y-linked 2 [Source:HGNC Symbol;Acc:HGNC:23950]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000306549#ENSG00000169953#ENST00000304790#HSF#$#ENSP00000340971#ENSG00000169953#ENST00000344884#HSF#$#ENSP00000372303#ENSG00000169953#ENST00000382852#HSF#	FALSE
1504	ENSG00000125347	IRF1	IRF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001346;IPR017431;IPR019817;	3659	interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116]	1IF1	DBD	Yes	None	Requires phosphorylation for proper dimeric function; Jaspar model binds similar sites than the other homologs	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:3409321;12517966	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000125347#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:15509808	$#ENSP00000245414#ENSG00000125347#ENST00000245414#Interferon regulatory factor (IRF)#$#ENSP00000480887#ENSG00000125347#ENST00000613424#Interferon regulatory factor (IRF)#$#ENSP00000473661#ENSG00000125347#ENST00000476613#Interferon regulatory factor (IRF)#$#ENSP00000405655#ENSG00000125347#ENST00000437654#Interferon regulatory factor (IRF)#	FALSE
1505	ENSG00000168310	IRF2	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR017431;IPR019817;	3660	interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117]	2IRF	DBD and Full	Yes	None	Requires phosphorylation for proper dimeric function	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798551;7687740	Yes	1a1, Direct HQ evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000168310#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IMP - PMID:9540062$#ENSG00000168310#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:9540062	$#ENSP00000377218#ENSG00000168310#ENST00000393593#Interferon regulatory factor (IRF)#$#ENSP00000422860#ENSG00000168310#ENST00000506230#Interferon regulatory factor (IRF)#$#ENSP00000423074#ENSG00000168310#ENST00000502750#Interferon regulatory factor (IRF)#$#ENSP00000421927#ENSG00000168310#ENST00000505067#Interferon regulatory factor (IRF)#	FALSE
1506	ENSG00000126456	IRF3	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR008984;IPR019471;IPR019817	3661	interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118]	2O6G	DBD and Full	Yes	None	Requires phosphorylation for proper dimeric function	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9660935	No	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000126456#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000310127#ENSG00000126456#ENST00000309877#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000366339#ENSG00000126456#ENST00000377135#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000366344#ENSG00000126456#ENST00000377139#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000400378#ENSG00000126456#ENST00000442265#Interferon regulatory factor (IRF)#$#ENSP00000472601#ENSG00000126456#ENST00000593922#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470512#ENSG00000126456#ENST00000596765#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470069#ENSG00000126456#ENST00000599144#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471358#ENSG00000126456#ENST00000599223#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000472700#ENSG00000126456#ENST00000600022#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471896#ENSG00000126456#ENST00000601291#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471517#ENSG00000126456#ENST00000593818#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000469113#ENSG00000126456#ENST00000597198#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000471402#ENSG00000126456#ENST00000601373#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470140#ENSG00000126456#ENST00000601809#Interferon regulatory factor (IRF)#$#ENSP00000473176#ENSG00000126456#ENST00000593337#Interferon regulatory factor (IRF)#$#ENSP00000469067#ENSG00000126456#ENST00000595034#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000468911#ENSG00000126456#ENST00000596822#Interferon regulatory factor (IRF)#$#ENSP00000472223#ENSG00000126456#ENST00000598108#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000470905#ENSG00000126456#ENST00000600453#Interferon regulatory factor (IRF)#	FALSE
1507	ENSG00000137265	IRF4	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR008984;IPR019471;IPR019817	3662	interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119]	None	DBD and Full	Yes	None	Requires phosphorylation for proper dimeric function	a	Yes	No	Yes	1a1, Direct HQ evidence	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000137265#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12374808$#ENSG00000137265#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024 | NAS - PMID:12374808	$#ENSP00000370343#ENSG00000137265#ENST00000380956#Interferon regulatory factor (IRF)#IRF-3, MH2	FALSE
1508	ENSG00000128604	IRF5	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR001346;IPR008984;IPR019471;IPR019817	3663	interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120]	None	DBD and Full	Yes	None	Requires phosphorylation for proper dimeric function	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:12600985;15308637	No	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000128604#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000249375#ENSG00000128604#ENST00000249375#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000349770#ENSG00000128604#ENST00000357234#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000385352#ENSG00000128604#ENST00000402030#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000419950#ENSG00000128604#ENST00000477535#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000483292#ENSG00000128604#ENST00000619830#Interferon regulatory factor (IRF)#	FALSE
1509	ENSG00000117595	IRF6	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR008984;IPR019471;IPR019817	3664	interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121]	None	DBD and Full	Yes	None	Requires phosphorylation for proper dimeric function	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000117595#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000355988#ENSG00000117595#ENST00000367021#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000440532#ENSG00000117595#ENST00000542854#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000403855#ENSG00000117595#ENST00000456314#Interferon regulatory factor (IRF)#IRF-3	FALSE
1510	ENSG00000185507	IRF7	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR008984;IPR019471;IPR019817	3665	interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122]	None	DBD	Yes	None	Requires phosphorylation for proper dimeric function	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9786932	Yes	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000185507#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17404045	$#ENSP00000331803#ENSG00000185507#ENST00000348655#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000380697#ENSG00000185507#ENST00000397566#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000380700#ENSG00000185507#ENST00000397570#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000380704#ENSG00000185507#ENST00000397574#Interferon regulatory factor (IRF)#IRF-3	FALSE
1511	ENSG00000140968	IRF8	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR008984;IPR019471;IPR019817	3394	interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358]	None	DBD and Full	not tested	None	Requires phosphorylation for proper dimeric function	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1460054;10734131	Yes	1a1, Direct HQ evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000140968#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:1460054	$#ENSP00000268638#ENSG00000140968#ENST00000268638#Interferon regulatory factor (IRF)#IRF-3, MH2$#ENSP00000458047#ENSG00000140968#ENST00000563180#Interferon regulatory factor (IRF)#$#ENSP00000456992#ENSG00000140968#ENST00000564803#Interferon regulatory factor (IRF)#IRF-3$#ENSP00000455452#ENSG00000140968#ENST00000562492#Interferon regulatory factor (IRF)#IRF-3, MH2$#ENSP00000455816#ENSG00000140968#ENST00000565552#Interferon regulatory factor (IRF)#$#ENSP00000455048#ENSG00000140968#ENST00000566369#Interferon regulatory factor (IRF)#$#ENSP00000455760#ENSG00000140968#ENST00000569145#Interferon regulatory factor (IRF)#$#ENSP00000456395#ENSG00000140968#ENST00000569607#Interferon regulatory factor (IRF)#IRF-3, MH2	FALSE
1512	ENSG00000213928	IRF9	IRF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001346;IPR008984;IPR019471;IPR019817	10379	interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131]	None	DBD	not tested	None	Requires phosphorylation for proper dimeric function	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10497156;12574168	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000213928#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000380073#ENSG00000213928#ENST00000396864#Interferon regulatory factor (IRF)#IRF-3	FALSE
1513	ENSG00000145220	LYAR	LYAR-type C2H2 ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	LYAR-type C2H2 ZF domains have not been shown to bind DNA. LYAR binds to the 60S subunit of the ribosome. It regulates translation rather than transcription (PMID: 24990247).	None	None	Ly1 antibody reactive	None	not tested	not tested	None	LYAR-type C2H2 ZF domains have not been shown to bind DNA. LYAR binds to the 60S subunit of the ribosome. It regulates translation rather than transcription (PMID: 24990247).	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
1514	ENSG00000188981	MSANTD1	MADF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	None	345222	Myb/SANT DNA binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:33741]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000423547#ENSG00000188981#ENST00000507492#MADF#$#ENSP00000411584#ENSG00000188981#ENST00000438480#MADF#$#ENSP00000420966#ENSG00000188981#ENST00000510580#MADF#	FALSE
1515	ENSG00000066697	MSANTD3	MADF	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR028002;	91283	Myb/SANT DNA binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:23370]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000378506#ENSG00000066697#ENST00000395067#MADF#$#ENSP00000364020#ENSG00000066697#ENST00000374885#MADF#$#ENSP00000480445#ENSG00000066697#ENST00000613183#MADF#$#ENSP00000364021#ENSG00000066697#ENST00000374886#MADF#$#ENSP00000415830#ENSG00000066697#ENST00000398977#MADF#$#ENSP00000480622#ENSG00000066697#ENST00000622639#MADF#	FALSE
1516	ENSG00000171169	NAIF1	MADF	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR028002;	203245	nuclear apoptosis inducing factor 1 [Source:HGNC Symbol;Acc:HGNC:25446]	None	not tested	not tested	None	None	No	Yes	No	No	1a2, Orthologous HQ evidence	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000362170#ENSG00000171169#ENST00000373078#MADF#	FALSE
1517	ENSG00000064489	BORCS8-MEF2B	MADS box	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR002100;IPR019320	4207	BORCS8-MEF2B readthrough [Source:HGNC Symbol;Acc:HGNC:39979]	None	DBD and Full	not tested	None	None	No	Yes	No	No	1a2, Orthologous HQ evidence	Laura Campitelli	Matt Weirauch	No	None	$#ENSP00000390762#ENSG00000064489#ENST00000444486#MADS box#$#ENSP00000454967#ENSG00000064489#ENST00000514819#MADS box#	FALSE
1518	ENSG00000068305	MEF2A	MADS box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002100;IPR022102	4205	Myocyte enhancer factor 2A [Source:HGNC Symbol;Acc:HGNC:6993]	1C7U	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000068305#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:10748098, PMID:16484498, PMID:20590529$#ENSG00000068305#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7760790$#ENSG00000068305#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16043483$#ENSG00000068305#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000346389#ENSG00000068305#ENST00000354410#MADS box#HJURP_C$#ENSP00000337202#ENSG00000068305#ENST00000338042#MADS box#HJURP_C$#ENSP00000454120#ENSG00000068305#ENST00000558812#MADS box#HJURP_C$#ENSP00000452989#ENSG00000068305#ENST00000559903#MADS box#	FALSE
1519	ENSG00000213999	MEF2B	MADS box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002100;	100271849	myocyte enhancer factor 2B [Source:HGNC Symbol;Acc:HGNC:6995]	1N6J	DBD	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000213999#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7760790$#ENSG00000213999#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8575763	$#ENSP00000386480#ENSG00000213999#ENST00000409224#MADS box#$#ENSP00000386784#ENSG00000213999#ENST00000409447#MADS box#$#ENSP00000386374#ENSG00000213999#ENST00000410050#MADS box#$#ENSP00000402154#ENSG00000213999#ENST00000424583#MADS box#	FALSE
1520	ENSG00000081189	MEF2C	MADS box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002100;IPR022102	4208	myocyte enhancer factor 2C [Source:HGNC Symbol;Acc:HGNC:6996]	None	DBD and Full	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000081189#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - PMID:21610032$#ENSG00000081189#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IDA - PMID:8455629$#ENSG00000081189#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15486975$#ENSG00000081189#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000081189#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16043483	$#ENSP00000340874#ENSG00000081189#ENST00000340208#MADS box#HJURP_C$#ENSP00000389610#ENSG00000081189#ENST00000424173#MADS box#HJURP_C$#ENSP00000396219#ENSG00000081189#ENST00000437473#MADS box#HJURP_C$#ENSP00000421925#ENSG00000081189#ENST00000504921#MADS box#HJURP_C$#ENSP00000487184#ENSG00000081189#ENST00000626391#MADS box#HJURP_C$#ENSP00000487311#ENSG00000081189#ENST00000628656#MADS box#$#ENSP00000427163#ENSG00000081189#ENST00000502983#MADS box#HJURP_C$#ENSP00000424331#ENSG00000081189#ENST00000507984#MADS box#HJURP_C$#ENSP00000427309#ENSG00000081189#ENST00000509373#MADS box#$#ENSP00000490525#ENSG00000081189#ENST00000635898#MADS box#$#ENSP00000490473#ENSG00000081189#ENST00000636294#MADS box#HJURP_C$#ENSP00000489865#ENSG00000081189#ENST00000636541#MADS box#HJURP_C$#ENSP00000490630#ENSG00000081189#ENST00000636998#MADS box#HJURP_C$#ENSP00000490354#ENSG00000081189#ENST00000637481#MADS box#HJURP_C$#ENSP00000490241#ENSG00000081189#ENST00000637732#MADS box#HJURP_C	FALSE
1521	ENSG00000116604	MEF2D	MADS box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002100;IPR022102	4209	myocyte enhancer factor 2D [Source:HGNC Symbol;Acc:HGNC:6997]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7760790;8269842	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000116604#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:20590529$#ENSG00000116604#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000116604#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8575763	$#ENSP00000271555#ENSG00000116604#ENST00000348159#MADS box#HJURP_C$#ENSP00000353803#ENSG00000116604#ENST00000360595#MADS box#HJURP_C$#ENSP00000357223#ENSG00000116604#ENST00000368240#MADS box#HJURP_C	FALSE
1522	ENSG00000112658	SRF	MADS box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002100;	6722	serum response factor [Source:HGNC Symbol;Acc:HGNC:11291]	1SRS	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11278806;15728583;16170155	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000112658#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IMP - PMID:18296735$#ENSG00000112658#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20808827$#ENSG00000112658#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#ISS - GO_REF:0000024$#ENSG00000112658#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:3203386$#ENSG00000112658#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000112658#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19098903	$#ENSP00000265354#ENSG00000112658#ENST00000265354#MADS box#	FALSE
1523	ENSG00000123636	BAZ2B	MBD	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	None	IPR001487;IPR001739;IPR001965;IPR004022;IPR011011;IPR016177;IPR018359;IPR018500;IPR018501;IPR019787	29994	bromodomain adjacent to zinc finger domain 2B [Source:HGNC Symbol;Acc:HGNC:963]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000376533#ENSG00000123636#ENST00000392782#Methyl-CpG DNA-binding#Bromodomain, DDT, Nop14, PHD, WSD$#ENSP00000400505#ENSG00000123636#ENST00000426648#Methyl-CpG DNA-binding#$#ENSP00000393565#ENSG00000123636#ENST00000441143#Methyl-CpG DNA-binding#	FALSE
1524	ENSG00000134046	MBD2	MBD	Yes	Known motif	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook	None	IPR001739;IPR016177;IPR025884;	8932	methyl-CpG binding domain protein 2 [Source:HGNC Symbol;Acc:HGNC:6917]	2KY8	Full	not tested	None	Structure has DNA with methylated CpG site	x	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_Non-specific DNA; Other_PMIDS:10471499;14610093	No	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	No	None	$#ENSP00000256429#ENSG00000134046#ENST00000256429#Methyl-CpG DNA-binding#MBD_C$#ENSP00000464554#ENSG00000134046#ENST00000583046#Methyl-CpG DNA-binding#$#ENSP00000381435#ENSG00000134046#ENST00000398398#Methyl-CpG DNA-binding#	FALSE
1525	ENSG00000071655	MBD3	MBD	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	The MBD domain of MBD3 is thought to be primarily responsible for interaction with HDAC1 and MTA2, members of the NuRD complex (PMID: 12124384). More recently, studies have shown that it retains the ability to bind methylated CpG sites in vitro (PMID: 24307175) with lower affinity than other MBD proteins (e.g., MBD2), but does not distinguish between hydroxymethylated and unmethylated sites. Coupled with in vivo ChIP experiments, it appears that MBD3 binds unmethylated CpG sites in vivo after be	IPR001739;IPR016177;IPR025884;	53615	methyl-CpG binding domain protein 3 [Source:HGNC Symbol;Acc:HGNC:6918]	None	not tested	not tested	None	Binds methylated CpG dinucleotides	x	Yes	No	No	3a, decent circumstantial evidence for its role as	Laura Campitelli	Tim Hughes	No	None	$#ENSP00000156825#ENSG00000071655#ENST00000156825#Methyl-CpG DNA-binding#MBD_C$#ENSP00000412302#ENSG00000071655#ENST00000434436#Methyl-CpG DNA-binding#MBD_C$#ENSP00000464718#ENSG00000071655#ENST00000590550#Methyl-CpG DNA-binding#MBD_C, MBDa, RasGAP	FALSE
1526	ENSG00000129071	MBD4	MBD	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR001739;IPR003265;IPR011257;IPR016177;IPR017352;	8930	methyl-CpG binding domain 4, DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:6919]	2MOE	not tested	not tested	None	Structure has DNA with methylated CpG site	x	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000249910#ENSG00000129071#ENST00000249910#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000376959#ENSG00000129071#ENST00000393278#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000394080#ENSG00000129071#ENST00000429544#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000424873#ENSG00000129071#ENST00000503197#Methyl-CpG DNA-binding#HhH-GPD$#ENSP00000422327#ENSG00000129071#ENST00000507208#Methyl-CpG DNA-binding#HhH-GPD	FALSE
1527	ENSG00000166987	MBD6	MBD	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Has not been tested on PBM or HT-SELEX. Some evidence exists showing that it does not bind methylated DNA (PMID: 20700456), and the MBD domain instead facilitates protein interactions (PMID: 24634419).	IPR001739;IPR016177	114785	methyl-CpG binding domain protein 6 [Source:HGNC Symbol;Acc:HGNC:20445]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000347896#ENSG00000166987#ENST00000355673#Methyl-CpG DNA-binding#$#ENSP00000448202#ENSG00000166987#ENST00000546632#Methyl-CpG DNA-binding#$#ENSP00000450160#ENSG00000166987#ENST00000552163#Methyl-CpG DNA-binding#$#ENSP00000446834#ENSG00000166987#ENST00000552659#Methyl-CpG DNA-binding#	FALSE
1528	ENSG00000127445	PIN1	MBD	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR000297;IPR001202;IPR023058	5300	peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16227615	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000247970#ENSG00000127445#ENST00000247970#Methyl-CpG DNA-binding#Rotamase, Rotamase_2, Rotamase_3, WW$#ENSP00000466656#ENSG00000127445#ENST00000587625#Methyl-CpG DNA-binding#Rotamase, Rotamase_3, WW$#ENSP00000466962#ENSG00000127445#ENST00000588695#Methyl-CpG DNA-binding#Rotamase, Rotamase_2, Rotamase_3, WW	FALSE
1529	ENSG00000143379	SETDB1	MBD	Yes	Known motif	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac motif is dubious.	IPR001214;IPR001739;IPR002999;IPR003606;IPR003616;IPR007728;IPR016177;IPR025796	9869	SET domain bifurcated 1 [Source:HGNC Symbol;Acc:HGNC:10761]	None	not tested	not tested	None	None	x	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14536086	No	2a1, Lower confidence direct evidence	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000271640#ENSG00000143379#ENST00000271640#Methyl-CpG DNA-binding#DUF4537, Pre-SET, SET$#ENSP00000357958#ENSG00000143379#ENST00000368962#Methyl-CpG DNA-binding#DUF4537$#ENSP00000357965#ENSG00000143379#ENST00000368969#Methyl-CpG DNA-binding#DUF4537, Pre-SET, SET$#ENSP00000436148#ENSG00000143379#ENST00000534805#Methyl-CpG DNA-binding#DUF4537$#ENSP00000432348#ENSG00000143379#ENST00000498193#Methyl-CpG DNA-binding#DUF4537, Pre-SET, SET$#ENSP00000407831#ENSG00000143379#ENST00000423081#Methyl-CpG DNA-binding#	FALSE
1530	ENSG00000136169	SETDB2	MBD	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR001214;IPR001739;IPR003606;IPR007728;IPR016177;	83852	SET domain bifurcated 2 [Source:HGNC Symbol;Acc:HGNC:20263]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Matt Weirauch	No	None	$#ENSP00000326477#ENSG00000136169#ENST00000317257#Methyl-CpG DNA-binding#Pre-SET, SET$#ENSP00000346175#ENSG00000136169#ENST00000354234#Methyl-CpG DNA-binding#Pre-SET, SET$#ENSP00000258672#ENSG00000136169#ENST00000258672#Methyl-CpG DNA-binding#Pre-SET, SET$#ENSP00000482240#ENSG00000136169#ENST00000611815#Methyl-CpG DNA-binding#Pre-SET, SET	FALSE
1531	ENSG00000076108	BAZ2A	MBD; AT hook	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Component of the silencing nucleolar remodelling complex (NoRC) (PMID: 22368283)	IPR001487;IPR001739;IPR001965;IPR004022;IPR011011;IPR016177;IPR017956;IPR018359;IPR018500;IPR018501;IPR019787;	11176	bromodomain adjacent to zinc finger domain 2A [Source:HGNC Symbol;Acc:HGNC:962]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000368754#ENSG00000076108#ENST00000379441#Methyl-CpG DNA-binding#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000448760#ENSG00000076108#ENST00000549787#Methyl-CpG DNA-binding#Bromodomain, PHD, WSD$#ENSP00000446880#ENSG00000076108#ENST00000551812#Methyl-CpG DNA-binding#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000447248#ENSG00000076108#ENST00000549506#Methyl-CpG DNA-binding#$#ENSP00000447941#ENSG00000076108#ENST00000549884#Methyl-CpG DNA-binding#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000449496#ENSG00000076108#ENST00000546695#Methyl-CpG DNA-binding#$#ENSP00000449473#ENSG00000076108#ENST00000547650#Methyl-CpG DNA-binding#	FALSE
1532	ENSG00000169057	MECP2	MBD; AT hook	Yes	Known motif	Low specificity DNA-binding protein	100 perc ID - in vitro	None	Binds methylated CpG dinucleotides (PDB: 3C2I)	IPR001739;IPR016177;IPR017353;	4204	methyl-CpG binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6990]	3C2I	not tested	Yes	None	Binds methylated CpG dinucleotides	x	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:8177735;9038338	No	3a, decent circumstantial evidence for its role as	Pratyush Das	Arttu Jolma	No	$#ENSG00000169057#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000301948#ENSG00000169057#ENST00000303391#Methyl-CpG DNA-binding#$#ENSP00000395535#ENSG00000169057#ENST00000453960#Methyl-CpG DNA-binding#$#ENSP00000486978#ENSG00000169057#ENST00000628176#Methyl-CpG DNA-binding#$#ENSP00000489847#ENSG00000169057#ENST00000637917#Methyl-CpG DNA-binding#	FALSE
1533	ENSG00000141644	MBD1	MBD; CxxC ZF	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds CpG methylated DNA (PDB: 1IG4). It is unclear how much other specificity has been defined.	IPR001739;IPR002857;IPR016177;	4152	methyl-CpG binding domain protein 1 [Source:HGNC Symbol;Acc:HGNC:6916]	1IG4	Full	not tested	None	Structure has DNA with methylated CpG site	x	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_DNA Binding_PMIDS:15060159;15691849	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	None	$#ENSP00000339546#ENSG00000141644#ENST00000339998#Methyl-CpG DNA-binding#$#ENSP00000285102#ENSG00000141644#ENST00000347968#Methyl-CpG DNA-binding#$#ENSP00000269469#ENSG00000141644#ENST00000353909#Methyl-CpG DNA-binding#$#ENSP00000381502#ENSG00000141644#ENST00000398488#Methyl-CpG DNA-binding#$#ENSP00000466092#ENSG00000141644#ENST00000585672#Methyl-CpG DNA-binding#$#ENSP00000467763#ENSG00000141644#ENST00000588937#Methyl-CpG DNA-binding#$#ENSP00000468785#ENSG00000141644#ENST00000590208#Methyl-CpG DNA-binding#$#ENSP00000465923#ENSG00000141644#ENST00000591535#Methyl-CpG DNA-binding#$#ENSP00000467606#ENSG00000141644#ENST00000592060#Methyl-CpG DNA-binding#$#ENSP00000372407#ENSG00000141644#ENST00000382948#Methyl-CpG DNA-binding#$#ENSP00000405268#ENSG00000141644#ENST00000457839#Methyl-CpG DNA-binding#$#ENSP00000468430#ENSG00000141644#ENST00000585595#Methyl-CpG DNA-binding#$#ENSP00000468042#ENSG00000141644#ENST00000587605#Methyl-CpG DNA-binding#$#ENSP00000466429#ENSG00000141644#ENST00000589733#Methyl-CpG DNA-binding#$#ENSP00000466806#ENSG00000141644#ENST00000589541#Methyl-CpG DNA-binding#	FALSE
1534	ENSG00000127989	MTERF1	mTERF	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	The structure (PDB: 3MVA) shows a large protein DNA-interaction interface.	IPR003690	7978	mitochondrial transcription termination factor 1 [Source:HGNC Symbol;Acc:HGNC:21463]	3MVA	not tested	not tested	None	Structure has really big protein DNA-interaction interface	No	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000248643#ENSG00000127989#ENST00000351870#mTERF#$#ENSP00000414116#ENSG00000127989#ENST00000419292#mTERF#$#ENSP00000400966#ENSG00000127989#ENST00000425936#mTERF#$#ENSP00000384986#ENSG00000127989#ENST00000406735#mTERF#	FALSE
1535	ENSG00000120832	MTERF2	mTERF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR003690;	80298	mitochondrial transcription termination factor 2 [Source:HGNC Symbol;Acc:HGNC:30779]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$#ENSP00000240050#ENSG00000120832#ENST00000240050#mTERF#$#ENSP00000376575#ENSG00000120832#ENST00000392830#mTERF#$#ENSP00000447651#ENSG00000120832#ENST00000552029#mTERF#$#ENSP00000448343#ENSG00000120832#ENST00000548101#mTERF#$#ENSP00000448246#ENSG00000120832#ENST00000550496#mTERF#$#ENSP00000448854#ENSG00000120832#ENST00000550736#mTERF#	FALSE
1536	ENSG00000156469	MTERF3	mTERF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Crystral structure available (PMID: 20430012)	IPR003690;	51001	mitochondrial transcription termination factor 3 [Source:HGNC Symbol;Acc:HGNC:24258]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000287025#ENSG00000156469#ENST00000287025#mTERF#Pex14_N$#ENSP00000429400#ENSG00000156469#ENST00000523821#mTERF#Pex14_N$#ENSP00000430138#ENSG00000156469#ENST00000522822#mTERF#$#ENSP00000429526#ENSG00000156469#ENST00000517720#mTERF#$#ENSP00000429267#ENSG00000156469#ENST00000524341#mTERF#	FALSE
1537	ENSG00000122085	MTERF4	mTERF	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	MTERF4 can bind RNA (PMID: 22949673), but likely to also bind DNA like other mTERF family members.	IPR003690;IPR016024	130916	mitochondrial transcription termination factor 4 [Source:HGNC Symbol;Acc:HGNC:28785]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	None	$#ENSP00000375840#ENSG00000122085#ENST00000391980#mTERF#$#ENSP00000480378#ENSG00000122085#ENST00000614476#mTERF#$#ENSP00000384998#ENSG00000122085#ENST00000406593#mTERF#$#ENSP00000385630#ENSG00000122085#ENST00000407095#mTERF#$#ENSP00000413346#ENSG00000122085#ENST00000449133#mTERF#$#ENSP00000414989#ENSG00000122085#ENST00000439144#mTERF#	FALSE
1538	ENSG00000183091	NEB	mTERF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Gene Cards/GO indicates that NEB is not present in the nucleus; and it appears to be an actin binding protein highly expressed in muscle.	IPR000900;IPR001452;IPR013998	4703	nebulin [Source:HGNC Symbol;Acc:HGNC:7720]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000172853#ENSG00000183091#ENST00000172853#mTERF#NFRKB_winged, Nebulin, Peptidase_M24, SH3_1, SH3_2$#ENSP00000410961#ENSG00000183091#ENST00000413693#mTERF#Nebulin, SH3_1, SH3_2, SH3_9$#ENSP00000404876#ENSG00000183091#ENST00000424585#mTERF#Nebulin	FALSE
1539	ENSG00000258315	C17orf49	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 1 SANT domain, suggesting it cannot bind DNA specifically	IPR009057;	124944	chromosome 17 open reading frame 49 [Source:HGNC Symbol;Acc:HGNC:28737]	None	Full	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000411851#ENSG00000258315#ENST00000439424#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000448598#ENSG00000258315#ENST00000546495#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000448746#ENSG00000258315#ENST00000552402#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1540	ENSG00000096401	CDC5L	Myb/SANT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Compelling evidence for DNA binding (PMID: 11082045).	IPR001005;IPR009057;IPR017930;IPR021786	988	cell division cycle 5 like [Source:HGNC Symbol;Acc:HGNC:1743]	None	DBD and Full	not tested	None	None	a	Yes	TF Evidence Conflict - There is evidence for and against this genes role as a TF___PMIDS:0;8917598;9038199;10570151;11082045;8917598;9038199;10570151;11118137	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Matt Weirauch	Yes	$#ENSG00000096401#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000360532#ENSG00000096401#ENST00000371477#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_Cef	FALSE
1541	ENSG00000173575	CHD2	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook	Although CHD2 has weak similarity to a Myb domain (PMID: 9326634), its more closely related to the non-DNA-binding SANT domain based on the alignment analysis. The data showing that show that CHD2 binding histone H3.3 (PMID:22569126) further support the conclusion that the Myb domain is probably a SANT domain facilitating the histone interaction	IPR000330;IPR000953;IPR001650;IPR014001;IPR016197;IPR023779;IPR023780;IPR025260;IPR027417;	100422995	chromodomain helicase DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:1917]	None	not tested	not tested	None	None	x	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Pratyush Das	No	None	$#ENSP00000406581#ENSG00000173575#ENST00000420239#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo$#ENSP00000486417#ENSG00000173575#ENST00000625243#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo$#ENSP00000486391#ENSG00000173575#ENST00000625463#Myb, Myb-Like, and SANT Domain Containing Genes#Helicase_C$#ENSP00000486629#ENSG00000173575#ENST00000626874#Myb, Myb-Like, and SANT Domain Containing Genes#CHDCT2, Chromo, DUF4208, Helicase_C, ResIII, SNF2_$#ENSP00000486487#ENSG00000173575#ENST00000626782#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo$#ENSP00000486926#ENSG00000173575#ENST00000627622#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000489976#ENSG00000173575#ENST00000637613#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo	FALSE
1542	ENSG00000007545	CRAMP1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a single SANT domain, no evidence for sequence-specific DNA binding	IPR001005;IPR017884	57585	cramped chromatin regulator homolog 1 [Source:HGNC Symbol;Acc:HGNC:14122]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	Yes	None	$#ENSP00000399172#ENSG00000007545#ENST00000415022#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000293925#ENSG00000007545#ENST00000293925#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_7$#ENSP00000380559#ENSG00000007545#ENST00000397412#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_7	FALSE
1543	ENSG00000135164	DMTF1	Myb/SANT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains 2 Myb DBDs. Binds to CCCG(G/T)ATGT (PMID: 8887674)	IPR001005;IPR009057;IPR017877;IPR017930	9988	cyclin D binding myb like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:14603]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8425553;9786929	Yes	3a, decent circumstantial evidence for its role as	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000135164#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000135164#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10095122	$#ENSP00000332171#ENSG00000135164#ENST00000331242#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000378193#ENSG00000135164#ENST00000394703#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000416499#ENSG00000135164#ENST00000425705#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000412532#ENSG00000135164#ENST00000432937#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000463239#ENSG00000135164#ENST00000582204#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000410288#ENSG00000135164#ENST00000454008#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000461920#ENSG00000135164#ENST00000582925#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1544	ENSG00000136770	DNAJC1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains	IPR001005;IPR001623;IPR009057;IPR017884;IPR018253;	64215	DnaJ heat shock protein family (Hsp40) member C1 [Source:HGNC Symbol;Acc:HGNC:20090]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000366179#ENSG00000136770#ENST00000376980#Myb, Myb-Like, and SANT Domain Containing Genes#DnaJ	FALSE
1545	ENSG00000105821	DNAJC2	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains	IPR001005;IPR001623;IPR009057;IPR017884;IPR018253;	27000	DnaJ heat shock protein family (Hsp40) member C2 [Source:HGNC Symbol;Acc:HGNC:13192]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	Yes	None	$#ENSP00000249270#ENSG00000105821#ENST00000249270#Myb, Myb-Like, and SANT Domain Containing Genes#DnaJ$#ENSP00000368565#ENSG00000105821#ENST00000379263#Myb, Myb-Like, and SANT Domain Containing Genes#DnaJ, RAC_head$#ENSP00000406275#ENSG00000105821#ENST00000412522#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1546	ENSG00000156030	ELMSAN1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a single SANT domain, no evidence for sequence-specific DNA binding	IPR000949;IPR001005;IPR009057;IPR017884	91748	ELM2 and Myb/SANT domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19853]	None	DBD	not tested	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000156030#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000286523#ENSG00000156030#ENST00000286523#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000377634#ENSG00000156030#ENST00000394071#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000402380#ENSG00000156030#ENST00000435371#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000407767#ENSG00000156030#ENST00000423556#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1547	ENSG00000162929	KIAA1841	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Domain is truncated, and there is nothing known about this gene	IPR021777;	84542	KIAA1841 [Source:HGNC Symbol;Acc:HGNC:29387]	None	not tested	Yes	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000295031#ENSG00000162929#ENST00000295031#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342$#ENSP00000385579#ENSG00000162929#ENST00000402291#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342$#ENSP00000416795#ENSG00000162929#ENST00000453873#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342$#ENSP00000482126#ENSG00000162929#ENST00000612149#Myb, Myb-Like, and SANT Domain Containing Genes#DUF3342	FALSE
1548	ENSG00000198160	MIER1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a single SANT domain, no evidence for sequence-specific DNA binding	IPR000949;IPR001005;IPR009057;IPR017884	57708	MIER1 transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:29657]	None	DBD and Full	Yes	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000347514#ENSG00000198160#ENST00000355356#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000350321#ENSG00000198160#ENST00000357692#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000360055#ENSG00000198160#ENST00000371016#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000360057#ENSG00000198160#ENST00000371018#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000383821#ENSG00000198160#ENST00000401042#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000360051#ENSG00000198160#ENST00000371012#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000360053#ENSG00000198160#ENST00000371014#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000383820#ENSG00000198160#ENST00000401041#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1549	ENSG00000105556	MIER2	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	MIER2s Myb domain is more similar to the non-DNA-binding SANT domain	IPR000949;IPR001005;IPR009057;IPR017884	54531	MIER family member 2 [Source:HGNC Symbol;Acc:HGNC:29210]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000264819#ENSG00000105556#ENST00000264819#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000482489#ENSG00000105556#ENST00000619835#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1550	ENSG00000155545	MIER3	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	MIER3s Myb domain is more similar to the non-DNA-binding SANT domain. Tested on both PBM and HT-SELEX, with no motif.	IPR000949;IPR001005;IPR009057;IPR017884	166968	MIER family member 3 [Source:HGNC Symbol;Acc:HGNC:26678]	None	DBD and Full	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Matt Weirauch	Yes	None	$#ENSP00000370596#ENSG00000155545#ENST00000381199#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000370611#ENSG00000155545#ENST00000381213#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000370624#ENSG00000155545#ENST00000381226#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000386584#ENSG00000155545#ENST00000409421#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1551	ENSG00000129534	MIS18BP1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 1 SANT domain, and a SANTA domain	IPR001005;IPR009057;IPR015216;IPR017884	55320	MIS18 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:20190]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000309790#ENSG00000129534#ENST00000310806#Myb, Myb-Like, and SANT Domain Containing Genes#SANTA$#ENSP00000397184#ENSG00000129534#ENST00000451174#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000487102#ENSG00000129534#ENST00000627697#Myb, Myb-Like, and SANT Domain Containing Genes#SANTA	FALSE
1552	ENSG00000170903	MSANTD4	Myb/SANT	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contains a single Myb-like domain with an insertion in the middle. It is ambiguous whether Myb-like domains are DNA or protein binding. Since it has a single domain its likely non-specific.	IPR028002	84437	Myb/SANT DNA binding domain containing 4 with coiled-coils [Source:HGNC Symbol;Acc:HGNC:29383]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000304713#ENSG00000170903#ENST00000301919#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_5$#ENSP00000435125#ENSG00000170903#ENST00000530788#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_5$#ENSP00000435372#ENSG00000170903#ENST00000530108#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_5$#ENSP00000432245#ENSG00000170903#ENST00000534458#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1553	ENSG00000118513	MYB	Myb/SANT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Contains 3 Myb DBDs	IPR001005;IPR009057;IPR012642;IPR015395;IPR017877;IPR017930	4602	MYB proto-oncogene, transcription factor [Source:HGNC Symbol;Acc:HGNC:7545]	1MSE	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12244173;15691758	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000118513#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000118513#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IC - GO_REF:0000036	$#ENSP00000339992#ENSG00000118513#ENST00000341911#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000356788#ENSG00000118513#ENST00000367814#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000410825#ENSG00000118513#ENST00000442647#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000435938#ENSG00000118513#ENST00000525369#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000434723#ENSG00000118513#ENST00000528774#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000436605#ENSG00000118513#ENST00000533624#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C$#ENSP00000435055#ENSG00000118513#ENST00000534044#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000432851#ENSG00000118513#ENST00000534121#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN	FALSE
1554	ENSG00000185697	MYBL1	Myb/SANT	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Contains 3 Myb DBDs	IPR001005;IPR009057;IPR012642;IPR015395;IPR017877;IPR017930	4603	MYB proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:7547]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7987850	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000185697#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7987850	$#ENSP00000429633#ENSG00000185697#ENST00000522677#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000428011#ENSG00000185697#ENST00000524176#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C, LMSTEN$#ENSP00000428265#ENSG00000185697#ENST00000517885#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C	FALSE
1555	ENSG00000101057	MYBL2	Myb/SANT	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Contains 3 Myb DBDs	IPR001005;IPR009057;IPR015395;IPR017877;IPR017930;	4605	MYB proto-oncogene like 2 [Source:HGNC Symbol;Acc:HGNC:7548]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1861984;8631934;11997503	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000101057#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10770937$#ENSG00000101057#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10770937	$#ENSP00000217026#ENSG00000101057#ENST00000217026#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C$#ENSP00000380072#ENSG00000101057#ENST00000396863#Myb, Myb-Like, and SANT Domain Containing Genes#Cmyb_C	FALSE
1556	ENSG00000176182	MYPOP	Myb/SANT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains a single Myb-like domain. Mouse ortholog has motif	IPR001005;IPR017877;IPR028002;	339344	Myb-related transcription factor, partner of profilin [Source:HGNC Symbol;Acc:HGNC:20178]	None	not tested	not tested	None	None	c	No	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	No	$#ENSG00000176182#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000325402#ENSG00000176182#ENST00000322217#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1557	ENSG00000162601	MYSM1	Myb/SANT	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	MYSM1 has been shown to bind DNA. This interaction requires the MYSM1 Myb but not the SWIRM domain (PMID: 17428495). Domain sequence alignment places it near DNA-binding Myb domains but scores slightly higher as a SANT rather than Myb domain based on Prosite patterns. Given that most Myb proteins that bind DNA sequence specifically have multiple Myb domains in an array, this protein could bind DNA sequence non-specifically with its single Myb domain.	IPR000555;IPR001005;IPR007526;IPR009057;IPR017884;	114803	Myb like, SWIRM and MPN domains 1 [Source:HGNC Symbol;Acc:HGNC:29401]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000478391#ENSG00000162601#ENST00000622766#Myb, Myb-Like, and SANT Domain Containing Genes#JAB, Prok-JAB$#ENSP00000418734#ENSG00000162601#ENST00000472487#Myb, Myb-Like, and SANT Domain Containing Genes#JAB, Prok-JAB, SWIRM	FALSE
1558	ENSG00000141027	NCOR1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains. Member of N-CoR deacetylase complex (PMID: 14527417).	IPR001005;IPR009057;IPR017884;	9611	nuclear receptor corepressor 1 [Source:HGNC Symbol;Acc:HGNC:7672]	None	Full	not tested	None	None	x	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:11997503;12628926	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	Yes	None	$#ENSP00000268712#ENSG00000141027#ENST00000268712#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000379189#ENSG00000141027#ENST00000395848#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000379192#ENSG00000141027#ENST00000395851#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000407998#ENSG00000141027#ENST00000411510#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000389839#ENSG00000141027#ENST00000436068#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000387727#ENSG00000141027#ENST00000436828#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000462308#ENSG00000141027#ENST00000582357#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000379190#ENSG00000141027#ENST00000395849#Myb, Myb-Like, and SANT Domain Containing Genes#FAM27$#ENSP00000463169#ENSG00000141027#ENST00000580554#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000474008#ENSG00000141027#ENST00000603989#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1559	ENSG00000196498	NCOR2	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains	IPR001005;IPR009057;IPR017884;	9612	Nuclear receptor corepressor 2 [Source:HGNC Symbol;Acc:HGNC:7673]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000384202#ENSG00000196498#ENST00000404621#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000384018#ENSG00000196498#ENST00000405201#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact, Spt20$#ENSP00000400281#ENSG00000196498#ENST00000429285#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000402808#ENSG00000196498#ENST00000458234#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000405367#ENSG00000196498#ENST00000420698#Myb, Myb-Like, and SANT Domain Containing Genes#GPS2_interact$#ENSP00000407357#ENSG00000196498#ENST00000413172#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000391389#ENSG00000196498#ENST00000418829#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000398963#ENSG00000196498#ENST00000440337#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000408247#ENSG00000196498#ENST00000448614#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000443689#ENSG00000196498#ENST00000542927#Myb, Myb-Like, and SANT Domain Containing Genes#DivIC, GPS2_interact	FALSE
1560	ENSG00000019485	PRDM11	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%)	None	None	PR/SET domain 11	None	not tested	Yes	None	SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%)	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1561	ENSG00000089902	RCOR1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains. Plays a well-established co-repressor role in the histone LSD1/RCOR1 de-methylase complex. There is some evidence that the protein contacts extranucleosomal DNA (PMID: 25916846).	IPR000949;IPR001005;IPR009057;IPR017884	23186	REST corepressor 1 [Source:HGNC Symbol;Acc:HGNC:17441]	None	DBD	not tested	None	None	a	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000089902#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10449787	$#ENSP00000262241#ENSG00000089902#ENST00000262241#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1562	ENSG00000167771	RCOR2	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains	IPR000949;IPR001005;IPR009057;IPR017884	283248	REST corepressor 2 [Source:HGNC Symbol;Acc:HGNC:27455]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10449787;16079794	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000167771#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000301459#ENSG00000167771#ENST00000301459#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1563	ENSG00000117625	RCOR3	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 2 SANT domains, and no other putative DNA-binding domains. RCOR3 SANT domains are known to facilitate PPIs. Known co-repressor - likely recruited by multiple TFs, as reviewed in (PMID: 24820421).	IPR000949;IPR001005;IPR009057;IPR017884	55758	REST corepressor 3 [Source:HGNC Symbol;Acc:HGNC:25594]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000117625#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000355972#ENSG00000117625#ENST00000367005#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000355973#ENSG00000117625#ENST00000367006#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000413929#ENSG00000117625#ENST00000419091#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000398558#ENSG00000117625#ENST00000452621#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000433441#ENSG00000117625#ENST00000534460#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1564	ENSG00000102038	SMARCA1	Myb/SANT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	SMARCA1 contains a truncated Myb-like and SANT domain. Given the presence of the Myb-like domain, and other domains known to associated with DNA (DEAD box helicase) it likely associates with DNA non-sequence-specifically	IPR000330;IPR001005;IPR001650;IPR009057;IPR014001;IPR015194;IPR015195;IPR017884;IPR020838;IPR027417	6594	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 [S	None	not tested	not tested	None	None	x	Yes	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:1408766;10415348;11031099	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Sam Lambert	Yes	None	$#ENSP00000360162#ENSG00000102038#ENST00000371121#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, HAND, HDA2-3, Helicase_C, ResIII, SNF$#ENSP00000360163#ENSG00000102038#ENST00000371122#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, HAND, HDA2-3, Helicase_C, ResIII, SNF$#ENSP00000360164#ENSG00000102038#ENST00000371123#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, ERCC3_RAD25_C, HAND, HDA2-3, Helicase	FALSE
1565	ENSG00000153147	SMARCA5	Myb/SANT	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	Contains a SANT, and Myb-like domain. Chromatin remodeling complex component that operates in DNA repair (PMID: 24990377); interacts with DNA, but presumably in non-sequence specific manner.	IPR000330;IPR001005;IPR001650;IPR009057;IPR014001;IPR015194;IPR015195;IPR017884;IPR020838;IPR027417	8467	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [S	None	not tested	Yes	None	None	x	Yes	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:12368916	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Matt Weirauch	Yes	None	$#ENSP00000283131#ENSG00000153147#ENST00000283131#Myb, Myb-Like, and SANT Domain Containing Genes#DBINO, DEAD, ERCC3_RAD25_C, HAND, HDA2-3, Helicase	FALSE
1566	ENSG00000173473	SMARCC1	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 1 SANT domain, and no other putative DNA-binding domains. Given that SMARCC1 is part of the Swi/Snf chromatin remodelling complex, its Myb/Sant domain is likely involved in binding histone tails. Available motif logos ares likely specificifities of SMARCC1 interactors.	IPR000953;IPR001005;IPR001357;IPR007526;IPR009057;IPR017884	6599	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [Sou	None	Full	Yes	None	WRONG SITE ChIP-seq model has a bZIP CRE-like sequence, SWI-SNF class nucleosome remodeling complex protein (active ATP-ase)	x	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI; Transactivation_PMIDS:15923603;11018012	No	2a1, Lower confidence direct evidence	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000254480#ENSG00000173473#ENST00000254480#Myb, Myb-Like, and SANT Domain Containing Genes#SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM-assoc_3	FALSE
1567	ENSG00000139613	SMARCC2	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains 1 SANT domain, and no other putative DNA-binding domains. Available motif logos ares likely specificifities of SMARCC2 interactors.	IPR000953;IPR001005;IPR001357;IPR007526;IPR009057;IPR017884	6601	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 [Sou	None	not tested	not tested	None	WRONG SITE ChIP-seq model has a bZIP CRE-like sequence, SWI-SNF class nucleosome remodeling complex protein (active ATP-ase)	x	Yes	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Pratyush Das	Yes	None	$#ENSP00000267064#ENSG00000139613#ENST00000267064#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM$#ENSP00000302919#ENSG00000139613#ENST00000347471#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM$#ENSP00000377591#ENSG00000139613#ENST00000394023#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM$#ENSP00000449396#ENSG00000139613#ENST00000550164#Myb, Myb-Like, and SANT Domain Containing Genes#Chromo, SWIRM, SWIRM-assoc_1, SWIRM-assoc_2, SWIRM	FALSE
1568	ENSG00000165684	SNAPC4	Myb/SANT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	EMSA data available showing it can specifically bind DNA (PMID: 9418884)	IPR001005;IPR009057;IPR017877;IPR017930	6621	small nuclear RNA activating complex polypeptide 4 [Source:HGNC Symbol;Acc:HGNC:11137]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: non-sequence-specific; Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI_PMIDS:9418884	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000165684#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000165684#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9418884	$#ENSP00000298532#ENSG00000165684#ENST00000298532#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000490037#ENSG00000165684#ENST00000637388#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1569	ENSG00000276234	TADA2A	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	TADA2A contains a single SANT domain and is thus unlikely to bind DNA	IPR001005;IPR007526;IPR009057;IPR016827;IPR017884	6871	transcriptional adaptor 2A [Source:HGNC Symbol;Acc:HGNC:11531]	None	not tested	not tested	None	None	No	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000276234#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8552087	$#ENSP00000481091#ENSG00000276234#ENST00000615182#Myb, Myb-Like, and SANT Domain Containing Genes#SWIRM$#ENSP00000477709#ENSG00000276234#ENST00000612272#Myb, Myb-Like, and SANT Domain Containing Genes#SWIRM$#ENSP00000484884#ENSG00000276234#ENST00000621780#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000478418#ENSG00000276234#ENST00000614112#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1570	ENSG00000173011	TADA2B	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	TADA2B contains a single SANT domain and is thus unlikely to bind DNA	IPR000433;IPR001005;IPR009057;IPR016827;IPR017884;	93624	transcriptional adaptor 2B [Source:HGNC Symbol;Acc:HGNC:30781]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000173011#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000308022#ENSG00000173011#ENST00000310074#Myb, Myb-Like, and SANT Domain Containing Genes#ZZ, zf-B_box$#ENSP00000423947#ENSG00000173011#ENST00000512388#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000422398#ENSG00000173011#ENST00000506692#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000423181#ENSG00000173011#ENST00000515646#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1571	ENSG00000249961	TERB1	Myb/SANT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains a single Myb domain (with slightly less similarity to a SANT domain). This domain has been shown to be involved in PPIs (PMID: 24413433), but this may not be mutually exclusive with DNA-binding.	IPR001005;IPR009057;IPR016024;	283847	telomere repeat binding bouquet formation protein 1 [Source:HGNC Symbol;Acc:HGNC:26675]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000462482#ENSG00000249961#ENST00000559050#Myb, Myb-Like, and SANT Domain Containing Genes#Atx10homo_assoc, HEAT$#ENSP00000462842#ENSG00000249961#ENST00000559403#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000463762#ENSG00000249961#ENST00000433154#Myb, Myb-Like, and SANT Domain Containing Genes#Atx10homo_assoc, DUF4704$#ENSP00000462883#ENSG00000249961#ENST00000558713#Myb, Myb-Like, and SANT Domain Containing Genes#Atx10homo_assoc, DUF4704	FALSE
1572	ENSG00000147601	TERF1	Myb/SANT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375).	IPR001005;IPR009057;IPR013867;IPR017357;IPR017930;	7013	telomeric repeat binding factor 1 [Source:HGNC Symbol;Acc:HGNC:11728]	1IV6	not tested	Yes	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000276602#ENSG00000147601#ENST00000276602#Myb, Myb-Like, and SANT Domain Containing Genes#TRF$#ENSP00000276603#ENSG00000147601#ENST00000276603#Myb, Myb-Like, and SANT Domain Containing Genes#TRF$#ENSP00000430121#ENSG00000147601#ENST00000517390#Myb, Myb-Like, and SANT Domain Containing Genes#TRF$#ENSP00000428838#ENSG00000147601#ENST00000518874#Myb, Myb-Like, and SANT Domain Containing Genes#TRF	FALSE
1573	ENSG00000132604	TERF2	Myb/SANT	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	The sequence in the crystal structure (PDB:1VFC), GTTAGGGTTAGGG, matches the inferred mouse motif.	IPR001005;IPR009057;IPR013867;IPR017357;IPR017930;	7014	telomeric repeat binding factor 2 [Source:HGNC Symbol;Acc:HGNC:11729]	1VFC	Full	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000254942#ENSG00000132604#ENST00000254942#Myb, Myb-Like, and SANT Domain Containing Genes#TERF2_RBM, TRF$#ENSP00000454955#ENSG00000132604#ENST00000567296#Myb, Myb-Like, and SANT Domain Containing Genes#PCI, TRF$#ENSP00000456022#ENSG00000132604#ENST00000566750#Myb, Myb-Like, and SANT Domain Containing Genes#PCI, TERF2_RBM, TRF$#ENSP00000475507#ENSG00000132604#ENST00000569584#Myb, Myb-Like, and SANT Domain Containing Genes#TERF2_RBM, TRF$#ENSP00000463079#ENSG00000132604#ENST00000566051#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1574	ENSG00000166848	TERF2IP	Myb/SANT	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a single Myb-like domain. Forms a complex with TERF2, where it modulates the binding of TERF2 to telomeres (PMID: 25675958).  Unclear if TERF2IP contacts DNA directly.	IPR009057;IPR015010;IPR021661;	54386	TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246]	None	not tested	not tested	None	Taipale Lab, Unpublished HT-SELEX, direct	x	No	No	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	No	$#ENSG00000166848#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000300086#ENSG00000166848#ENST00000300086#Myb, Myb-Like, and SANT Domain Containing Genes#BRCT_2, Myb_DNA-bind_2, Rap1_C$#ENSP00000456092#ENSG00000166848#ENST00000564671#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1575	ENSG00000125482	TTF1	Myb/SANT	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Contains Myb and Myb-like domains, and is annotated as a Pol1 terminator.  DNA-binding has been demonstrated in vitro via EMSA (PMID: 7597036).	IPR001005;IPR017877	7270	transcription termination factor 1 [Source:HGNC Symbol;Acc:HGNC:12397]	None	not tested	Yes	None	None	x	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7720715;9049305	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000125482#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000333920#ENSG00000125482#ENST00000334270#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000481441#ENSG00000125482#ENST00000612514#Myb, Myb-Like, and SANT Domain Containing Genes#Myb_DNA-bind_6	FALSE
1576	ENSG00000036549	ZZZ3	Myb/SANT	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Contains 1 Myb DBD	IPR000433;IPR001005;IPR009057;IPR017930	26009	zinc finger ZZ-type containing 3 [Source:HGNC Symbol;Acc:HGNC:24523]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000359834#ENSG00000036549#ENST00000370798#Myb, Myb-Like, and SANT Domain Containing Genes#ZZ$#ENSP00000359837#ENSG00000036549#ENST00000370801#Myb, Myb-Like, and SANT Domain Containing Genes#ZZ$#ENSP00000392408#ENSG00000036549#ENST00000414381#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000393779#ENSG00000036549#ENST00000433749#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1577	ENSG00000182979	MTA1	Myb/SANT; GATA	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). The GATA ZnF domain of MTA1 is required for its interaction with RBBP4 and RBBP7 (PMID:18067919). Full-length protein has been tried in HT-SELEX and did not yield a motif	IPR000679;IPR000949;IPR001005;IPR001025;IPR009057;IPR017884	9112	metastasis associated 1 [Source:HGNC Symbol;Acc:HGNC:7410]	None	Full	not tested	None	PMID: 26869315 Protein is a component of the nucleosome remodelling and deacetylase (NuRD) that isnt supposed to contact DNA directly	x	Yes	TF Gene_DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding_Non-specific DNA_PMIDS:12431981	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000182979#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000333633#ENSG00000182979#ENST00000331320#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000394106#ENSG00000182979#ENST00000434050#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000385702#ENSG00000182979#ENST00000406191#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2	FALSE
1578	ENSG00000149480	MTA2	Myb/SANT; GATA	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). Full-length protein has been tried in HT-SELEX, and DBD has been tried on PBM - neither yielded motifs	IPR000679;IPR000949;IPR001005;IPR001025;IPR009057;IPR017884	9219	metastasis associated 1 family member 2 [Source:HGNC Symbol;Acc:HGNC:7411]	None	Full	Yes	None	PMID: 26869315 Protein is a component of the nucleosome remodelling and deacetylase (NuRD) that isnt supposed to contact DNA directly	x	Yes	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Transactivation_PMIDS:11749719;15020045	No	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000149480#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000278823#ENSG00000149480#ENST00000278823#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000431346#ENSG00000149480#ENST00000524902#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2$#ENSP00000431797#ENSG00000149480#ENST00000527204#Myb, Myb-Like, and SANT Domain Containing Genes#ELM2	FALSE
1579	ENSG00000057935	MTA3	Myb/SANT; GATA	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). Hasnt been tried in any in vitro assays	IPR000679;IPR000949;IPR001005;IPR001025;IPR009057;IPR017884	57504	metastasis associated 1 family member 3 [Source:HGNC Symbol;Acc:HGNC:23784]	None	not tested	not tested	None	PMID: 26869315 Protein is a component of the nucleosome remodelling and deacetylase (NuRD) that isnt supposed to contact DNA directly	x	Yes	No	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000057935#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000384249#ENSG00000057935#ENST00000406652#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000385045#ENSG00000057935#ENST00000407270#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000383973#ENSG00000057935#ENST00000405592#Myb, Myb-Like, and SANT Domain Containing Genes#BAH, ELM2$#ENSP00000388722#ENSG00000057935#ENST00000433553#Myb, Myb-Like, and SANT Domain Containing Genes#	FALSE
1580	ENSG00000142599	RERE	Myb/SANT; GATA	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contains a GATA and SANT domain. Unclear whether the GATA domain is a bona fide DBD as the MTA/RERE family domains are atypical to human GATA domains (see alignment). In CIS-BP there is one protein from C.elegans that shares domain homology and binds a GATA motif (elg-27, ChIP-seq). Has been tried as a DBD in HT-SELEX but did not yield a motif	IPR000679;IPR000949;IPR001005;IPR001025;IPR002951;IPR009057;IPR017884;	473	arginine-glutamic acid dipeptide repeats [Source:HGNC Symbol;Acc:HGNC:9965]	None	DBD	Yes	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000142599#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000338629#ENSG00000142599#ENST00000337907#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1, BAH, ELM2$#ENSP00000383700#ENSG00000142599#ENST00000400908#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1, BAH, ELM2$#ENSP00000422246#ENSG00000142599#ENST00000476556#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1$#ENSP00000465271#ENSG00000142599#ENST00000468247#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000423451#ENSG00000142599#ENST00000505225#Myb, Myb-Like, and SANT Domain Containing Genes#Atrophin-1, Dsh_C$#ENSP00000464847#ENSG00000142599#ENST00000488215#Myb, Myb-Like, and SANT Domain Containing Genes#$#ENSP00000423259#ENSG00000142599#ENST00000514428#Myb, Myb-Like, and SANT Domain Containing Genes#BAH	FALSE
1581	ENSG00000197056	ZMYM1	MYM-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR008906;IPR010507;IPR011017;IPR012337;IPR025398	79830	zinc finger MYM-type containing 1 [Source:HGNC Symbol;Acc:HGNC:26253]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000197056#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000352920#ENSG00000197056#ENST00000359858#Other#DUF4371, Dimer_Tnp_hAT, zf-FCS$#ENSP00000362427#ENSG00000197056#ENST00000373330#Other#DUF4371, Dimer_Tnp_hAT, zf-FCS$#ENSP00000394233#ENSG00000197056#ENST00000417119#Other#zf-FCS$#ENSP00000482579#ENSG00000197056#ENST00000611874#Other#DUF4371, Dimer_Tnp_hAT, zf-FCS	FALSE
1582	ENSG00000121741	ZMYM2	MYM-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR010507;IPR011017;IPR021893	7750	zinc finger MYM-type containing 2 [Source:HGNC Symbol;Acc:HGNC:12989]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14651998	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000121741#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000372324#ENSG00000121741#ENST00000382871#Other#Arc_trans_TRASH, DUF3504, YHS, zf-FCS$#ENSP00000372327#ENSG00000121741#ENST00000382874#Other#Arc_trans_TRASH, DUF3504, YHS, zf-FCS$#ENSP00000479904#ENSG00000121741#ENST00000610343#Other#Arc_trans_TRASH, DUF3504, YHS, zf-FCS$#ENSP00000483904#ENSG00000121741#ENST00000620447#Other#YHS, zf-FCS, zf-FLZ	FALSE
1583	ENSG00000147130	ZMYM3	MYM-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The cassette of seven znf-MYM domains are used to bind SUMO (PMID: 25133527). Overall, very little is known about this domain or protein.	IPR010507;IPR011017;IPR021893	9203	zinc finger MYM-type containing 3 [Source:HGNC Symbol;Acc:HGNC:13054]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000147130#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000322845#ENSG00000147130#ENST00000314425#Other#Arc_trans_TRASH, DUF3504, NosL, YHS, zf-FCS$#ENSP00000363093#ENSG00000147130#ENST00000373981#Other#zf-FCS$#ENSP00000363110#ENSG00000147130#ENST00000373998#Other#Arc_trans_TRASH, DUF3504, NosL, YHS, zf-FCS	FALSE
1584	ENSG00000146463	ZMYM4	MYM-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Lacks a canonical DBD	IPR010507;IPR011017;IPR021893	9202	zinc finger MYM-type containing 4 [Source:HGNC Symbol;Acc:HGNC:13055]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000146463#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000322915#ENSG00000146463#ENST00000314607#Other#DUF3504, zf-FCS$#ENSP00000397524#ENSG00000146463#ENST00000441447#Other#$#ENSP00000400506#ENSG00000146463#ENST00000457946#Other#DUF3504, YHS, zf-FCS	FALSE
1585	ENSG00000132950	ZMYM5	MYM-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Binds to and represses activity of ETV5 based on (PMID: 17126306), but there is no evidence for it binding the DNA itself, so it seems like an co-repressor	IPR010507;IPR011017	9205	zinc finger MYM-type containing 5 [Source:HGNC Symbol;Acc:HGNC:13029]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000132950#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17126306	$#ENSP00000372361#ENSG00000132950#ENST00000382905#Other#YHS, zf-FCS$#ENSP00000372364#ENSG00000132950#ENST00000382907#Other#$#ENSP00000337034#ENSG00000132950#ENST00000337963#Other#ATPase-cat_bd, zf-FCS$#ENSP00000445779#ENSG00000132950#ENST00000502168#Other#ATPase-cat_bd, zf-FCS	FALSE
1586	ENSG00000163867	ZMYM6	MYM-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Truncated BED ZF	IPR010507;IPR011017;IPR012337;IPR025398	9204	zinc finger MYM-type containing 6 [Source:HGNC Symbol;Acc:HGNC:13050]	None	not tested	not tested	None	None	No	Yes	No	Yes	3a, decent circumstantial evidence for its role as	Jussi Taipale	Sam Lambert	No	$#ENSG00000163867#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000326695#ENSG00000163867#ENST00000317538#Other#zf-FCS$#ENSP00000349708#ENSG00000163867#ENST00000357182#Other#DUF4371, zf-FCS$#ENSP00000362430#ENSG00000163867#ENST00000373333#Other#zf-FCS$#ENSP00000391337#ENSG00000163867#ENST00000415531#Other#zf-FCS, zf-FLZ	FALSE
1587	ENSG00000004838	ZMYND10	MYND-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002893;IPR017333	51364	zinc finger MYND-type containing 10 [Source:HGNC Symbol;Acc:HGNC:19412]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11085536;12629521;16929489	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$##ENSG00000004838##Other#	FALSE
1588	ENSG00000124920	MYRF	Ndt80/PhoG	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Mouse ortholog binds a highly similar motif.	IPR008967;IPR024061;IPR025719;IPR026932;IPR030392;	745	myelin regulatory factor [Source:HGNC Symbol;Acc:HGNC:1181]	None	not tested	Yes	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Tim Hughes	Yes	$#ENSG00000124920#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000265460#ENSG00000124920#ENST00000265460#Other#MRF_C1, MRF_C2, Peptidase_S74$#ENSP00000278836#ENSG00000124920#ENST00000278836#Other#MRF_C1, MRF_C2, Peptidase_S74$#ENSP00000374253#ENSG00000124920#ENST00000389602#Other#MRF_C1, MRF_C2, Peptidase_S74	FALSE
1589	ENSG00000166268	MYRFL	Ndt80/PhoG	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Related to other MYRF TFs, which have related PBM motifs	IPR008967;IPR024061;IPR025719;IPR026932;IPR030392;	196446	myelin regulatory factor-like [Source:HGNC Symbol;Acc:HGNC:26316]	None	not tested	not tested	None	None	x	Yes	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000166268#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000440626#ENSG00000166268#ENST00000535034#Other#MRF_C2$#ENSP00000447167#ENSG00000166268#ENST00000548892#Other#MRF_C1, MRF_C2	FALSE
1590	ENSG00000086102	NFX1	NFX	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000967;IPR001374;IPR001841;IPR019786;IPR019787;	4799	nuclear transcription factor, X-box binding 1 [Source:HGNC Symbol;Acc:HGNC:7803]	None	DBD	Yes	None	None	a	Yes	TF Gene_Single stranded RNA/DNA binding_DNA Binding; Transactivation_PMIDS:7964459	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000086102#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:7964459$#ENSG00000086102#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7964459	$#ENSP00000317695#ENSG00000086102#ENST00000318524#NF-X1 ZF#$#ENSP00000368836#ENSG00000086102#ENST00000379521#NF-X1 ZF#$#ENSP00000368856#ENSG00000086102#ENST00000379540#NF-X1 ZF#R3H	FALSE
1591	ENSG00000170448	NFXL1	NFX	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Likely a TF based on presence of NFX ZF.	IPR000967;IPR001841;IPR019786;	152518	nuclear transcription factor, X-box binding like 1 [Source:HGNC Symbol;Acc:HGNC:18726]	None	not tested	not tested	None	None	c	Yes	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	$#ENSG00000170448#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000333113#ENSG00000170448#ENST00000329043#NF-X1 ZF#$#ENSP00000422037#ENSG00000170448#ENST00000507489#NF-X1 ZF#$#ENSP00000370949#ENSG00000170448#ENST00000381538#NF-X1 ZF#	FALSE
1592	ENSG00000109445	ZNF330	NOA36-type ZF	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein has IPR010531 domain, Zinc finger protein NOA36, which has not been shown to bind DNA	None	None	Zinc finger protein 330	None	not tested	not tested	None	Protein has IPR010531 domain, Zinc finger protein NOA36, which has not been shown to bind DNA	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1593	ENSG00000169083	AR	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001103;IPR001628;IPR001723;IPR008946;	367	androgen receptor [Source:HGNC Symbol;Acc:HGNC:644]	1R4I	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7685765;9211894	No	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000169083#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16728402$#ENSG00000169083#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11477070, PMID:15572661 | TAS - PMID:20$#ENSG00000169083#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17277772$#ENSG00000169083#GO:0004882#androgen receptor activity#IDA - PMID:12799378, PMID:19886863, PMID:20048160,$#ENSG00000169083#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21310825	$#ENSP00000363822#ENSG00000169083#ENST00000374690#Nuclear Hormone Receptor#Androgen_recep, Hormone_recep$#ENSP00000379358#ENSG00000169083#ENST00000396043#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000379359#ENSG00000169083#ENST00000396044#Nuclear Hormone Receptor#Androgen_recep$#ENSP00000421155#ENSG00000169083#ENST00000504326#Nuclear Hormone Receptor#Androgen_recep$#ENSP00000479013#ENSG00000169083#ENST00000613054#Nuclear Hormone Receptor#Androgen_recep	FALSE
1594	ENSG00000091831	ESR1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001292;IPR001628;IPR001723;IPR008946;IPR024178;IPR024736;	2099	estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467]	1HCQ	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10908317;16636675	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000091831#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12047722$#ENSG00000091831#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:12552091$#ENSG00000091831#GO:0038052#estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:15831516 | IGI - PMID:18722177$#ENSG00000091831#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10816575$#ENSG00000091831#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10681512, PMID:9328340	$#ENSP00000206249#ENSG00000091831#ENST00000206249#Nuclear Hormone Receptor#ESR1_C, Hormone_recep, Oest_recep$#ENSP00000385373#ENSG00000091831#ENST00000404742#Nuclear Hormone Receptor#Oest_recep$#ENSP00000384064#ENSG00000091831#ENST00000406599#Nuclear Hormone Receptor#ESR1_C, Hormone_recep, Oest_recep$#ENSP00000401995#ENSG00000091831#ENST00000415488#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000394721#ENSG00000091831#ENST00000427531#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000411105#ENSG00000091831#ENST00000446550#Nuclear Hormone Receptor#Oest_recep$#ENSP00000415934#ENSG00000091831#ENST00000456483#Nuclear Hormone Receptor#Oest_recep	FALSE
1595	ENSG00000140009	ESR2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946;IPR021064;IPR024178;IPR028355;	2100	estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:9058381;12047722;16484337	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000140009#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8769313$#ENSG00000140009#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#NAS - PMID:9671811$#ENSG00000140009#GO:0038052#estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:19126643$#ENSG00000140009#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10681512	$#ENSP00000267525#ENSG00000140009#ENST00000267525#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000343925#ENSG00000140009#ENST00000341099#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000335551#ENSG00000140009#ENST00000353772#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000452426#ENSG00000140009#ENST00000553796#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000450699#ENSG00000140009#ENST00000554572#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000450488#ENSG00000140009#ENST00000555278#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000451582#ENSG00000140009#ENST00000557772#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000351412#ENSG00000140009#ENST00000358599#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep$#ENSP00000452485#ENSG00000140009#ENST00000556275#Nuclear Hormone Receptor#ERbeta_N, Hormone_recep	FALSE
1596	ENSG00000173153	ESRRA	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946;IPR024178;IPR027289	2101	estrogen related receptor alpha [Source:HGNC Symbol;Acc:HGNC:3471]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9271417	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000173153#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000173153#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000173153#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:9286700	$#ENSP00000000442#ENSG00000173153#ENST00000000442#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000384851#ENSG00000173153#ENST00000405666#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000385971#ENSG00000173153#ENST00000406310#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000441970#ENSG00000173153#ENST00000468670#Nuclear Hormone Receptor#$#ENSP00000444710#ENSG00000173153#ENST00000545035#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000439896#ENSG00000173153#ENST00000539594#Nuclear Hormone Receptor#Hormone_recep	FALSE
1597	ENSG00000119715	ESRRB	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946;IPR024178;IPR027289	2103	estrogen related receptor beta [Source:HGNC Symbol;Acc:HGNC:3473]	1LO1	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:8626619;15766247	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000119715#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:9344655	$#ENSP00000422488#ENSG00000119715#ENST00000509242#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000451658#ENSG00000119715#ENST00000556177#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000370270#ENSG00000119715#ENST00000380887#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000424992#ENSG00000119715#ENST00000512784#Nuclear Hormone Receptor#Hormone_recep	FALSE
1598	ENSG00000196482	ESRRG	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003078;IPR008946;IPR024178;IPR027289;	2104	estrogen related receptor gamma [Source:HGNC Symbol;Acc:HGNC:3474]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15149736	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000196482#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000196482#GO:0003708#retinoic acid receptor activity#IEA - GO_REF:0000002	$#ENSP00000352077#ENSG00000196482#ENST00000359162#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000353108#ENSG00000196482#ENST00000360012#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000354584#ENSG00000196482#ENST00000361395#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000355904#ENSG00000196482#ENST00000366937#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000355905#ENSG00000196482#ENST00000366938#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000355907#ENSG00000196482#ENST00000366940#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000386171#ENSG00000196482#ENST00000408911#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000419514#ENSG00000196482#ENST00000475275#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000419155#ENSG00000196482#ENST00000487276#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000419594#ENSG00000196482#ENST00000493603#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000417374#ENSG00000196482#ENST00000493748#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000481528#ENSG00000196482#ENST00000616180#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000418629#ENSG00000196482#ENST00000463665#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000417900#ENSG00000196482#ENST00000469486#Nuclear Hormone Receptor#	FALSE
1599	ENSG00000101076	HNF4A	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000003;IPR000536;IPR001628;IPR001723;IPR003068;IPR008946	3172	hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024]	3CBB	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15581617	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000101076#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000101076#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10330009, PMID:12911579, PMID:16488887,$#ENSG00000101076#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000101076#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000312987#ENSG00000101076#ENST00000316099#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000315180#ENSG00000101076#ENST00000316673#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000412111#ENSG00000101076#ENST00000415691#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000410911#ENSG00000101076#ENST00000443598#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000396216#ENSG00000101076#ENST00000457232#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000476310#ENSG00000101076#ENST00000609262#Nuclear Hormone Receptor#$#ENSP00000476609#ENSG00000101076#ENST00000609795#Nuclear Hormone Receptor#Hormone_recep	FALSE
1600	ENSG00000164749	HNF4G	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000536;IPR001628;IPR001723;IPR003068;IPR008946;	3174	hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol;Acc:HGNC:5026]	None	DBD and Full	not tested	None	ChIP-seq model in Jaspar has similar consensus to HNF4A	a	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000164749#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8622695$#ENSG00000164749#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000346339#ENSG00000164749#ENST00000354370#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000379701#ENSG00000164749#ENST00000396423#Nuclear Hormone Receptor#Hormone_recep	FALSE
1601	ENSG00000126368	NR1D1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946	9572	nuclear receptor subfamily 1 group D member 1 [Source:HGNC Symbol;Acc:HGNC:7962]	1A6Y	DBD and Full	Yes	None	Structure is homodimer	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12021280;12150932	Yes	1a1, Direct HQ evidence	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000126368#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8622974$#ENSG00000126368#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:8622974	$#ENSP00000246672#ENSG00000126368#ENST00000246672#Nuclear Hormone Receptor#Hormone_recep	FALSE
1602	ENSG00000174738	NR1D2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946	9975	nuclear receptor subfamily 1 group D member 2 [Source:HGNC Symbol;Acc:HGNC:7963]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7838156	No	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000174738#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:7997240	$#ENSP00000310006#ENSG00000174738#ENST00000312521#Nuclear Hormone Receptor#Hormone_recep	FALSE
1603	ENSG00000131408	NR1H2	Nuclear receptor	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Likely an obligate heteromer (PMID: 7935418; PMID: 7892230; PMID: 7744246)	IPR000536;IPR001628;IPR001723;IPR008946;IPR023257;	7376	nuclear receptor subfamily 1 group H member 2 [Source:HGNC Symbol;Acc:HGNC:7965]	4NQA	DBD and Full	not tested	None	Structure is RXRA-NR1H2 heterodimer, with both the LBDs and DBDs	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16007255;17218271	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000131408#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9013544$#ENSG00000131408#GO:0001133#sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor#IEA - GO_REF:0000019$#ENSG00000131408#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000253727#ENSG00000131408#ENST00000253727#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000396151#ENSG00000131408#ENST00000411902#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000469778#ENSG00000131408#ENST00000597157#Nuclear Hormone Receptor#$#ENSP00000470518#ENSG00000131408#ENST00000597790#Nuclear Hormone Receptor#$#ENSP00000472138#ENSG00000131408#ENST00000597130#Nuclear Hormone Receptor#$#ENSP00000473099#ENSG00000131408#ENST00000600355#Nuclear Hormone Receptor#	FALSE
1604	ENSG00000025434	NR1H3	Nuclear receptor	Yes	Inferred motif	Obligate heteromer	In vivo/Misc source	None	Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA	IPR000536;IPR001628;IPR001723;IPR008946;IPR023257;	10062	nuclear receptor subfamily 1 group H member 3 [Source:HGNC Symbol;Acc:HGNC:7966]	None	DBD and Full	Yes	None	Pmid:21349840 Heterodimerizes with RXRA	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9013544	Yes	1a2, Orthologous HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000025434#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:7744246	$#ENSP00000378793#ENSG00000025434#ENST00000395397#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000384745#ENSG00000025434#ENST00000405853#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000387946#ENSG00000025434#ENST00000441012#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420656#ENSG00000025434#ENST00000467728#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000432073#ENSG00000025434#ENST00000527949#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000403798#ENSG00000025434#ENST00000436778#Nuclear Hormone Receptor#$#ENSP00000396132#ENSG00000025434#ENST00000437276#Nuclear Hormone Receptor#$#ENSP00000391005#ENSG00000025434#ENST00000444396#Nuclear Hormone Receptor#$#ENSP00000434650#ENSG00000025434#ENST00000531660#Nuclear Hormone Receptor#Hormone_recep	FALSE
1605	ENSG00000012504	NR1H4	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Also binds DNA as heterodimer with RXRA (PMID: 11870371)	IPR000536;IPR001628;IPR001723;IPR001728;IPR008946;	9971	nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11533040	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000012504#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:24211198$#ENSG00000012504#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10334992, PMID:9223286$#ENSG00000012504#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21757002$#ENSG00000012504#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - PMID:21757002$#ENSG00000012504#GO:0004887#thyroid hormone receptor activity#IEA - GO_REF:0000002$#ENSG00000012504#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000188403#ENSG00000012504#ENST00000188403#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000376712#ENSG00000012504#ENST00000392986#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000448506#ENSG00000012504#ENST00000548884#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000448978#ENSG00000012504#ENST00000549996#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000447149#ENSG00000012504#ENST00000551379#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000446760#ENSG00000012504#ENST00000546380#Nuclear Hormone Receptor#$#ENSP00000446861#ENSG00000012504#ENST00000551184#Nuclear Hormone Receptor#	FALSE
1606	ENSG00000144852	NR1I2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR001728;IPR008946;	8856	nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11114890	No	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000144852#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11114890$#ENSG00000144852#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12578355	$#ENSP00000336528#ENSG00000144852#ENST00000337940#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377319#ENSG00000144852#ENST00000393716#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420297#ENSG00000144852#ENST00000466380#Nuclear Hormone Receptor#Hormone_recep	FALSE
1607	ENSG00000143257	NR1I3	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR001728;IPR008946;	9970	nuclear receptor subfamily 1 group I member 3 [Source:HGNC Symbol;Acc:HGNC:7969]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8114692;12511605	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000143257#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:11114890$#ENSG00000143257#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8020947, PMID:8114692$#ENSG00000143257#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:8114692$#ENSG00000143257#GO:0004882#androgen receptor activity#TAS - PMID:9783588$#ENSG00000143257#GO:0004887#thyroid hormone receptor activity#IEA - GO_REF:0000002	$#ENSP00000356958#ENSG00000143257#ENST00000367979#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356960#ENSG00000143257#ENST00000367981#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356961#ENSG00000143257#ENST00000367982#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356962#ENSG00000143257#ENST00000367983#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356963#ENSG00000143257#ENST00000367984#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356965#ENSG00000143257#ENST00000367985#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000399361#ENSG00000143257#ENST00000412844#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000412672#ENSG00000143257#ENST00000428574#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000407446#ENSG00000143257#ENST00000437437#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000406493#ENSG00000143257#ENST00000442691#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000421374#ENSG00000143257#ENST00000502985#Nuclear Hormone Receptor#$#ENSP00000424345#ENSG00000143257#ENST00000504010#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000424934#ENSG00000143257#ENST00000505005#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000422982#ENSG00000143257#ENST00000508387#Nuclear Hormone Receptor#$#ENSP00000423666#ENSG00000143257#ENST00000508740#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000427175#ENSG00000143257#ENST00000511676#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000427600#ENSG00000143257#ENST00000511748#Nuclear Hormone Receptor#$#ENSP00000426292#ENSG00000143257#ENST00000511944#Nuclear Hormone Receptor#$#ENSP00000425417#ENSG00000143257#ENST00000512372#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000421588#ENSG00000143257#ENST00000515621#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000423089#ENSG00000143257#ENST00000506209#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000427034#ENSG00000143257#ENST00000515452#Nuclear Hormone Receptor#Hormone_recep	FALSE
1608	ENSG00000120798	NR2C1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946	7181	nuclear receptor subfamily 2 group C member 1 [Source:HGNC Symbol;Acc:HGNC:7971]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12849971	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000120798#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000376813#ENSG00000120798#ENST00000393101#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000333275#ENSG00000120798#ENST00000333003#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000446906#ENSG00000120798#ENST00000547469#Nuclear Hormone Receptor#	FALSE
1609	ENSG00000177463	NR2C2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946	7182	nuclear receptor subfamily 2 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7972]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9006963	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000177463#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644740	$#ENSP00000320447#ENSG00000177463#ENST00000323373#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000384463#ENSG00000177463#ENST00000406272#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000483059#ENSG00000177463#ENST00000617312#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000388387#ENSG00000177463#ENST00000425241#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000413438#ENSG00000177463#ENST00000413194#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000391473#ENSG00000177463#ENST00000435454#Nuclear Hormone Receptor#$#ENSP00000401807#ENSG00000177463#ENST00000437120#Nuclear Hormone Receptor#$#ENSP00000412473#ENSG00000177463#ENST00000439011#Nuclear Hormone Receptor#Hormone_recep	FALSE
1610	ENSG00000112333	NR2E1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946	7101	nuclear receptor subfamily 2 group E member 1 [Source:HGNC Symbol;Acc:HGNC:7973]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8047143;11073974	No	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000112333#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000112333#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000357982#ENSG00000112333#ENST00000368986#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000357979#ENSG00000112333#ENST00000368983#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000416908#ENSG00000112333#ENST00000426403#Nuclear Hormone Receptor#	FALSE
1611	ENSG00000278570	NR2E3	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001723;IPR001628;IPR000536;IPR013088	10002	Nuclear receptor subfamily 2 group E member 3 [Source:HGNC Symbol;Acc:HGNC:7974]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15689355	Yes	2a1, Lower confidence direct evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000278570#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:10220376	$#ENSP00000482504#ENSG00000278570#ENST00000617575#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000479962#ENSG00000278570#ENST00000621098#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000479254#ENSG00000278570#ENST00000621736#Nuclear Hormone Receptor#Hormone_recep	FALSE
1612	ENSG00000175745	NR2F1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003068;IPR008946;	7025	nuclear receptor subfamily 2 group F member 1 [Source:HGNC Symbol;Acc:HGNC:7975]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2739739;17009409	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000175745#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644740$#ENSG00000175745#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000325819#ENSG00000175745#ENST00000327111#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000481517#ENSG00000175745#ENST00000615873#Nuclear Hormone Receptor#Hormone_recep	FALSE
1613	ENSG00000185551	NR2F2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003068;IPR008946;	100302258	nuclear receptor subfamily 2 group F member 2 [Source:HGNC Symbol;Acc:HGNC:7976]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8622679	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000185551#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9343308$#ENSG00000185551#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:18798693	$#ENSP00000377721#ENSG00000185551#ENST00000394166#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000401674#ENSG00000185551#ENST00000421109#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000389853#ENSG00000185551#ENST00000453270#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377726#ENSG00000185551#ENST00000394171#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000457112#ENSG00000185551#ENST00000559679#Nuclear Hormone Receptor#Hormone_recep	FALSE
1614	ENSG00000160113	NR2F6	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003068;IPR008946;	2063	nuclear receptor subfamily 2 group F member 6 [Source:HGNC Symbol;Acc:HGNC:7977]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12690040	Yes	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000160113#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000160113#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10644740$#ENSG00000160113#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:2905047$#ENSG00000160113#GO:0004887#thyroid hormone receptor activity#TAS - PMID:2905047	$#ENSP00000291442#ENSG00000160113#ENST00000291442#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000471686#ENSG00000160113#ENST00000596878#Nuclear Hormone Receptor#Hormone_recep	FALSE
1615	ENSG00000113580	NR3C1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001409;IPR001628;IPR001723;IPR008946;	2908	nuclear receptor subfamily 3 group C member 1 [Source:HGNC Symbol;Acc:HGNC:7978]	1GLU	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16728402;67253380;15563547	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000113580#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16728402, PMID:23823477$#ENSG00000113580#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15769988, PMID:17635946	$#ENSP00000231509#ENSG00000113580#ENST00000231509#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000377977#ENSG00000113580#ENST00000394464#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000387672#ENSG00000113580#ENST00000415690#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000405282#ENSG00000113580#ENST00000424646#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000420856#ENSG00000113580#ENST00000502892#Nuclear Hormone Receptor#GCR$#ENSP00000427672#ENSG00000113580#ENST00000503201#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000422518#ENSG00000113580#ENST00000504572#Nuclear Hormone Receptor#GCR, Hormone_recep$#ENSP00000425313#ENSG00000113580#ENST00000508760#Nuclear Hormone Receptor#GCR$#ENSP00000424747#ENSG00000113580#ENST00000510170#Nuclear Hormone Receptor#GCR$#ENSP00000426478#ENSG00000113580#ENST00000514699#Nuclear Hormone Receptor#GCR	FALSE
1616	ENSG00000151623	NR3C2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR008946;	4306	nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979]	4TNT	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:3037703;8389140	No	1a1, Direct HQ evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000151623#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000350815#ENSG00000151623#ENST00000358102#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000423510#ENSG00000151623#ENST00000512865#Nuclear Hormone Receptor#	FALSE
1617	ENSG00000123358	NR4A1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003070;IPR003071;IPR008946	3164	nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7980]	1CIT	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16237153	Yes	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000123358#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000123358#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000243050#ENSG00000123358#ENST00000243050#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000378302#ENSG00000123358#ENST00000394825#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000449587#ENSG00000123358#ENST00000548232#Nuclear Hormone Receptor#$#ENSP00000353427#ENSG00000123358#ENST00000360284#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000440864#ENSG00000123358#ENST00000545748#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000457070#ENSG00000123358#ENST00000546842#Nuclear Hormone Receptor#$#ENSP00000456633#ENSG00000123358#ENST00000548977#Nuclear Hormone Receptor#$#ENSP00000456776#ENSG00000123358#ENST00000553200#Nuclear Hormone Receptor#$#ENSP00000455399#ENSG00000123358#ENST00000562373#Nuclear Hormone Receptor#	FALSE
1618	ENSG00000153234	NR4A2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003070;IPR003073;IPR008946	4929	nuclear receptor subfamily 4 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7981]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding; Transactivation_PMIDS:12122012;15485875	Yes	1a1, Direct HQ evidence	Arttu Jolma	Jussi Taipale	Yes	$#ENSG00000153234#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#ISS - GO_REF:0000024$#ENSG00000153234#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:16243425	$#ENSP00000344479#ENSG00000153234#ENST00000339562#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000406808#ENSG00000153234#ENST00000424077#Nuclear Hormone Receptor#$#ENSP00000389986#ENSG00000153234#ENST00000426264#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000385379#ENSG00000153234#ENST00000406048#Nuclear Hormone Receptor#	FALSE
1619	ENSG00000119508	NR4A3	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000536;IPR001628;IPR001723;IPR003070;IPR003072;IPR008946	8013	nuclear receptor subfamily 4 group A member 3 [Source:HGNC Symbol;Acc:HGNC:7982]	None	DBD	not tested	None	Taipale lab has an unpublished PWM that looks just like other NR4A TFs	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10875239	Yes	1a1, Direct HQ evidence	Matt Weirauch	Tim Hughes	Yes	$#ENSG00000119508#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20558821$#ENSG00000119508#GO:0004887#thyroid hormone receptor activity#TAS - PMID:8570200	$#ENSP00000340301#ENSG00000119508#ENST00000338488#Nuclear Hormone Receptor#$#ENSP00000378531#ENSG00000119508#ENST00000395097#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000333122#ENSG00000119508#ENST00000330847#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000482027#ENSG00000119508#ENST00000618101#Nuclear Hormone Receptor#Hormone_recep	FALSE
1620	ENSG00000136931	NR5A1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946;IPR016355;	2516	nuclear receptor subfamily 5 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7983]	2FF0	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:8463279;10913126	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000136931#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21412441$#ENSG00000136931#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:8205615	$#ENSP00000362690#ENSG00000136931#ENST00000373588#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000362689#ENSG00000136931#ENST00000373587#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000393245#ENSG00000136931#ENST00000455734#Nuclear Hormone Receptor#$#ENSP00000483309#ENSG00000136931#ENST00000620110#Nuclear Hormone Receptor#Hormone_recep	FALSE
1621	ENSG00000116833	NR5A2	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946;IPR016355;	2494	nuclear receptor subfamily 5 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7984]	2A66	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12456679;15014077	Yes	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000116833#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000116833#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15205472, PMID:15723037, PMID:16289203$#ENSG00000116833#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:9786908$#ENSG00000116833#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:16271724	$#ENSP00000236914#ENSG00000116833#ENST00000236914#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000356326#ENSG00000116833#ENST00000367357#Nuclear Hormone Receptor#$#ENSP00000356331#ENSG00000116833#ENST00000367362#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000414888#ENSG00000116833#ENST00000447034#Nuclear Hormone Receptor#$#ENSP00000439116#ENSG00000116833#ENST00000544748#Nuclear Hormone Receptor#Hormone_recep	FALSE
1622	ENSG00000148200	NR6A1	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR008946	2649	nuclear receptor subfamily 6 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7985]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9099702;15236322	Yes	1a1, Direct HQ evidence	Laura Campitelli	Pratyush Das	Yes	$#ENSG00000148200#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000148200#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#TAS - PMID:9134503	$#ENSP00000362686#ENSG00000148200#ENST00000373584#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000413701#ENSG00000148200#ENST00000416460#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420267#ENSG00000148200#ENST00000487099#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000420587#ENSG00000148200#ENST00000475178#Nuclear Hormone Receptor#	FALSE
1623	ENSG00000082175	PGR	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000128;IPR000536;IPR001628;IPR001723;IPR008946;	5241	progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910]	2C7A	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:5579944;12114521	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000082175#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17785366	$#ENSP00000263463#ENSG00000082175#ENST00000263463#Nuclear Hormone Receptor#Hormone_recep, Prog_receptor$#ENSP00000325120#ENSG00000082175#ENST00000325455#Nuclear Hormone Receptor#Hormone_recep, Prog_receptor$#ENSP00000436561#ENSG00000082175#ENST00000534013#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000487607#ENSG00000082175#ENST00000632634#Nuclear Hormone Receptor#Prog_receptor	FALSE
1624	ENSG00000186951	PPARA	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000536;IPR001628;IPR001723;IPR003074;IPR003076;IPR008946	5465	peroxisome proliferator activated receptor alpha [Source:HGNC Symbol;Acc:HGNC:9232]	None	DBD and Full	Yes	Obligate_Multimer	Heterodimerizes with RXR TFs	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1537328;8123021;8386511;12847522;9748239	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000186951#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9748239$#ENSG00000186951#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9748239$#ENSG00000186951#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:19955185 | ISS - GO_REF:0000024$#ENSG00000186951#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12955147, PMID:19955185	$#ENSP00000385246#ENSG00000186951#ENST00000402126#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000385523#ENSG00000186951#ENST00000407236#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000397291#ENSG00000186951#ENST00000440343#Nuclear Hormone Receptor#$#ENSP00000414752#ENSG00000186951#ENST00000420804#Nuclear Hormone Receptor#	FALSE
1625	ENSG00000112033	PPARD	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003074;IPR003075;IPR008946	5467	peroxisome proliferator activated receptor delta [Source:HGNC Symbol;Acc:HGNC:9235]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:11923467	Yes	1a1, Direct HQ evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000112033#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#ISS - GO_REF:0000024$#ENSG00000112033#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12955147 | NAS - PMID:11551955$#ENSG00000112033#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:12955147	$#ENSP00000353916#ENSG00000112033#ENST00000360694#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000413314#ENSG00000112033#ENST00000418635#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000414372#ENSG00000112033#ENST00000448077#Nuclear Hormone Receptor#Hormone_recep	FALSE
1626	ENSG00000132170	PPARG	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	Also heterodimerizes.	IPR000536;IPR001628;IPR001723;IPR003074;IPR003077;IPR008946;IPR022590;	5468	peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236]	3DZU	DBD and Full	Yes	Obligate_Multimer	Heterodimerizes with RXR TFs; crystal is PPARG-RXRA heterodimer; jaspar model is heterodimer of PPARG with  RXRA	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:14744933;15681609	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000132170#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9568715 | ISS - GO_REF:0000024$#ENSG00000132170#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:10622252$#ENSG00000132170#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18293083	$#ENSP00000287820#ENSG00000132170#ENST00000287820#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380196#ENSG00000132170#ENST00000397000#Nuclear Hormone Receptor#PPARgamma_N$#ENSP00000380205#ENSG00000132170#ENST00000397010#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380207#ENSG00000132170#ENST00000397012#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380210#ENSG00000132170#ENST00000397015#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000411931#ENSG00000132170#ENST00000455517#Nuclear Hormone Receptor#PPARgamma_N$#ENSP00000312472#ENSG00000132170#ENST00000309576#Nuclear Hormone Receptor#Hormone_recep, PPARgamma_N$#ENSP00000380224#ENSG00000132170#ENST00000397029#Nuclear Hormone Receptor#PPARgamma_N$#ENSP00000392285#ENSG00000132170#ENST00000438682#Nuclear Hormone Receptor#PPARgamma_N	FALSE
1627	ENSG00000131759	RARA	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003078;IPR008946;	5914	retinoic acid receptor alpha [Source:HGNC Symbol;Acc:HGNC:9864]	1DSZ	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1312934	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000131759#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18922886, PMID:20413580$#ENSG00000131759#GO:0003708#retinoic acid receptor activity#IDA - PMID:2825025	$#ENSP00000254066#ENSG00000131759#ENST00000254066#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377643#ENSG00000131759#ENST00000394081#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000389993#ENSG00000131759#ENST00000425707#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377648#ENSG00000131759#ENST00000394086#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377649#ENSG00000131759#ENST00000394089#Nuclear Hormone Receptor#Hormone_recep	FALSE
1628	ENSG00000077092	RARB	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003078;IPR008946;	5915	retinoic acid receptor beta [Source:HGNC Symbol;Acc:HGNC:9865]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2153268	No	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000077092#GO:0003708#retinoic acid receptor activity#IEA - GO_REF:0000019	$#ENSP00000332296#ENSG00000077092#ENST00000330688#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000398840#ENSG00000077092#ENST00000437042#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000391391#ENSG00000077092#ENST00000458646#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000373282#ENSG00000077092#ENST00000383772#Nuclear Hormone Receptor#Hormone_recep	FALSE
1629	ENSG00000172819	RARG	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003078;IPR008946;	5916	retinoic acid receptor gamma [Source:HGNC Symbol;Acc:HGNC:9866]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2544807;15327771	Yes	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000172819#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000172819#GO:0003708#retinoic acid receptor activity#IEA - GO_REF:0000019	$#ENSP00000343698#ENSG00000172819#ENST00000338561#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377947#ENSG00000172819#ENST00000394426#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000388510#ENSG00000172819#ENST00000425354#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000444335#ENSG00000172819#ENST00000543726#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000454385#ENSG00000172819#ENST00000550362#Nuclear Hormone Receptor#$#ENSP00000454604#ENSG00000172819#ENST00000551158#Nuclear Hormone Receptor#	FALSE
1630	ENSG00000069667	RORA	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003079;IPR008946;	6095	RAR related orphan receptor A [Source:HGNC Symbol;Acc:HGNC:10258]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7926749;7926749;15941850;15821743;7926749;12467577	Yes	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000069667#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11053433, PMID:17545671, PMID:18658046,$#ENSG00000069667#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002$#ENSG00000069667#GO:0098531#transcription factor activity, direct ligand regulated sequence-specific DNA binding#IDA - PMID:19965867	$#ENSP00000261523#ENSG00000069667#ENST00000261523#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000309753#ENSG00000069667#ENST00000309157#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000335087#ENSG00000069667#ENST00000335670#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000402971#ENSG00000069667#ENST00000449337#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000484955#ENSG00000069667#ENST00000558904#Nuclear Hormone Receptor#	FALSE
1631	ENSG00000198963	RORB	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003079;IPR008946;	6096	RAR related orphan receptor B [Source:HGNC Symbol;Acc:HGNC:10259]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7935491	Yes	1a1, Direct HQ evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000198963#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000198963#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000366093#ENSG00000198963#ENST00000376896#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000379507#ENSG00000198963#ENST00000396204#Nuclear Hormone Receptor#Hormone_recep	FALSE
1632	ENSG00000143365	RORC	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR003079;IPR008946;	6097	RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260]	None	DBD and Full	not tested	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000143365#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000143365#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000002$#ENSG00000143365#GO:0098531#transcription factor activity, direct ligand regulated sequence-specific DNA binding#IDA - PMID:19965867	$#ENSP00000327025#ENSG00000143365#ENST00000318247#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000349164#ENSG00000143365#ENST00000356728#Nuclear Hormone Receptor#Hormone_recep	FALSE
1633	ENSG00000186350	RXRA	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000003;IPR000536;IPR001628;IPR001723;IPR008946;IPR021780	6256	retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477]	1BY4	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:7838715;15544927	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000186350#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12037571, PMID:17426122, PMID:20219900$#ENSG00000186350#GO:0003708#retinoic acid receptor activity#TAS - PMID:19374686$#ENSG00000186350#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7990953$#ENSG00000186350#GO:0004886#9-cis retinoic acid receptor activity#IEA - GO_REF:0000019	$#ENSP00000419692#ENSG00000186350#ENST00000481739#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1	FALSE
1634	ENSG00000204231	RXRB	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Has been shown to bind both as a homodimer and with several nuclear receptor homodimerization partners	IPR000003;IPR000536;IPR001628;IPR001723;IPR008946;	6257	retinoid X receptor beta [Source:HGNC Symbol;Acc:HGNC:10478]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2554307;10393558	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000204231#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:12767074$#ENSG00000204231#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1662118$#ENSG00000204231#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7990953$#ENSG00000204231#GO:0004886#9-cis retinoic acid receptor activity#TAS - PMID:1662118	$#ENSP00000363812#ENSG00000204231#ENST00000374680#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1$#ENSP00000363817#ENSG00000204231#ENST00000374685#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1	FALSE
1635	ENSG00000143171	RXRG	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Usually binds in vivo as a heterodimer, but can bind as a homodimer in vitro	IPR000003;IPR000536;IPR001628;IPR001723;IPR008946;IPR021780	6258	retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000143171#GO:0004886#9-cis retinoic acid receptor activity#IEA - GO_REF:0000019	$#ENSP00000352900#ENSG00000143171#ENST00000359842#Nuclear Hormone Receptor#Hormone_recep, Nuc_recep-AF1$#ENSP00000482458#ENSG00000143171#ENST00000619224#Nuclear Hormone Receptor#Hormone_recep	FALSE
1636	ENSG00000126351	THRA	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Likely binds as a heterodimer too	IPR000536;IPR001628;IPR001723;IPR001728;IPR008946;	7067	thyroid hormone receptor, alpha [Source:HGNC Symbol;Acc:HGNC:11796]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:8559662;11773435	Yes	1a1, Direct HQ evidence	Sam Lambert	Tim Hughes	Yes	$#ENSG00000126351#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18052923, PMID:8710870, PMID:9653119$#ENSG00000126351#GO:0004887#thyroid hormone receptor activity#IDA - PMID:15466465, PMID:18052923, PMID:8710870	$#ENSP00000264637#ENSG00000126351#ENST00000264637#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000395641#ENSG00000126351#ENST00000450525#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000463466#ENSG00000126351#ENST00000584985#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000377679#ENSG00000126351#ENST00000394121#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000443972#ENSG00000126351#ENST00000546243#Nuclear Hormone Receptor#Hormone_recep	FALSE
1637	ENSG00000151090	THRB	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000536;IPR001628;IPR001723;IPR001728;IPR008946;	7068	thyroid hormone receptor beta [Source:HGNC Symbol;Acc:HGNC:11799]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1648450;1648451	Yes	1a1, Direct HQ evidence	Yimeng Yin	Sam Lambert	Yes	$#ENSG00000151090#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:1618799$#ENSG00000151090#GO:0004887#thyroid hormone receptor activity#IDA - PMID:15466465	$#ENSP00000348827#ENSG00000151090#ENST00000356447#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000404898#ENSG00000151090#ENST00000415021#Nuclear Hormone Receptor#$#ENSP00000395362#ENSG00000151090#ENST00000431815#Nuclear Hormone Receptor#$#ENSP00000388467#ENSG00000151090#ENST00000447875#Nuclear Hormone Receptor#$#ENSP00000414910#ENSG00000151090#ENST00000453729#Nuclear Hormone Receptor#$#ENSP00000414444#ENSG00000151090#ENST00000416420#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000393932#ENSG00000151090#ENST00000418247#Nuclear Hormone Receptor#$#ENSP00000414100#ENSG00000151090#ENST00000413780#Nuclear Hormone Receptor#	FALSE
1638	ENSG00000111424	VDR	Nuclear receptor	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000324;IPR000536;IPR001628;IPR001723;IPR008946;	7421	vitamin D (1,25- dihydroxyvitamin D3) receptor [Source:HGNC Symbol;Acc:HGNC:12679]	1KB2	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:16750418;8674817	Yes	1a1, Direct HQ evidence	Laura Campitelli	Tim Hughes	Yes	$#ENSG00000111424#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17426122$#ENSG00000111424#GO:0008434#vitamin D3 receptor activity#IDA - PMID:12016314, PMID:16549446, PMID:17082781	$#ENSP00000449573#ENSG00000111424#ENST00000549336#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000447173#ENSG00000111424#ENST00000550325#Nuclear Hormone Receptor#Hormone_recep$#ENSP00000449561#ENSG00000111424#ENST00000550314#Nuclear Hormone Receptor#	FALSE
1639	ENSG00000141510	TP53	p53	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR002117;IPR008967;IPR010991;IPR011615;IPR013872;	7157	tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998]	1TSR	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12082536	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000141510#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24652652$#ENSG00000141510#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:17146433$#ENSG00000141510#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18549481, PMID:7587074	$#ENSP00000269305#ENSG00000141510#ENST00000269305#p53#P53_TAD, P53_tetramer$#ENSP00000352610#ENSG00000141510#ENST00000359597#p53#P53_TAD$#ENSP00000410739#ENSG00000141510#ENST00000413465#p53#P53_TAD$#ENSP00000391127#ENSG00000141510#ENST00000420246#p53#P53_TAD$#ENSP00000391478#ENSG00000141510#ENST00000445888#p53#P53_TAD, P53_tetramer$#ENSP00000398846#ENSG00000141510#ENST00000455263#p53#P53_TAD$#ENSP00000484409#ENSG00000141510#ENST00000504290#p53#$#ENSP00000481179#ENSG00000141510#ENST00000504937#p53#P53_tetramer$#ENSP00000478499#ENSG00000141510#ENST00000510385#p53#$#ENSP00000423862#ENSG00000141510#ENST00000514944#p53#P53_TAD$#ENSP00000458393#ENSG00000141510#ENST00000576024#p53#$#ENSP00000478219#ENSG00000141510#ENST00000610292#p53#P53_tetramer$#ENSP00000480868#ENSG00000141510#ENST00000610538#p53#$#ENSP00000477531#ENSG00000141510#ENST00000610623#p53#$#ENSP00000482258#ENSG00000141510#ENST00000617185#p53#P53_TAD$#ENSP00000481401#ENSG00000141510#ENST00000618944#p53#$#ENSP00000484375#ENSG00000141510#ENST00000619186#p53#P53_tetramer$#ENSP00000482537#ENSG00000141510#ENST00000619485#p53#P53_tetramer$#ENSP00000481638#ENSG00000141510#ENST00000620739#p53#P53_tetramer$#ENSP00000482222#ENSG00000141510#ENST00000622645#p53#	FALSE
1640	ENSG00000073282	TP63	p53	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001660;IPR002117;IPR008967;IPR010991;IPR011510;IPR011615;IPR013761;	8626	tumor protein p63 [Source:HGNC Symbol;Acc:HGNC:15979]	3QYM	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate__Transactivation_PMIDS:9774969	Yes	1a1, Direct HQ evidence	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000073282#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000073282#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000264731#ENSG00000073282#ENST00000264731#p53#P53_tetramer, SAM_2$#ENSP00000317510#ENSG00000073282#ENST00000320472#p53#P53_tetramer$#ENSP00000346614#ENSG00000073282#ENST00000354600#p53#P53_tetramer, SAM_2$#ENSP00000376254#ENSG00000073282#ENST00000392461#p53#P53_tetramer$#ENSP00000376256#ENSG00000073282#ENST00000392463#p53#P53_tetramer$#ENSP00000407144#ENSG00000073282#ENST00000418709#p53#P53_tetramer$#ENSP00000392488#ENSG00000073282#ENST00000437221#p53#P53_tetramer$#ENSP00000387839#ENSG00000073282#ENST00000449992#p53#P53_tetramer, SAM_2	FALSE
1641	ENSG00000078900	TP73	p53	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001660;IPR002117;IPR008967;IPR010991;IPR011510;IPR011615;IPR013761;	7161	tumor protein p73 [Source:HGNC Symbol;Acc:HGNC:12003]	3VD0	DBD and Full	not tested	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000078900#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:24652652$#ENSG00000078900#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16343436$#ENSG00000078900#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15678106	$#ENSP00000367529#ENSG00000078900#ENST00000378280#p53#P53_tetramer$#ENSP00000367534#ENSG00000078900#ENST00000378285#p53#P53_tetramer$#ENSP00000367537#ENSG00000078900#ENST00000378288#p53#P53_tetramer, SAM_1, SAM_2$#ENSP00000367545#ENSG00000078900#ENST00000378295#p53#P53_tetramer, SAM_1, SAM_2$#ENSP00000367539#ENSG00000078900#ENST00000378290#p53#P53_tetramer, SAM_1, SAM_2	FALSE
1642	ENSG00000125813	PAX1	Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001523;IPR009057	5075	paired box 1 [Source:HGNC Symbol;Acc:HGNC:8615]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12490554	No	1a1, Direct HQ evidence	Laura Campitelli	Tim Hughes	Yes	$#ENSG00000125813#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000481334#ENSG00000125813#ENST00000613128#Paired Box#$#ENSP00000410355#ENSG00000125813#ENST00000444366#Paired Box#$#ENSP00000381499#ENSG00000125813#ENST00000398485#Paired Box#	FALSE
1643	ENSG00000196092	PAX5	Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	PDB:1K78 is a PAX5:ETS1 heterodimer	IPR001523;IPR009057;IPR022130;	5079	paired box 5 [Source:HGNC Symbol;Acc:HGNC:8619]	1K78	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8406007	No	1a1, Direct HQ evidence	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000196092#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000350844#ENSG00000196092#ENST00000358127#Paired Box#Pax2_C$#ENSP00000367078#ENSG00000196092#ENST00000377847#Paired Box#Pax2_C$#ENSP00000367083#ENSG00000196092#ENST00000377852#Paired Box#Pax2_C$#ENSP00000367084#ENSG00000196092#ENST00000377853#Paired Box#Pax2_C$#ENSP00000412188#ENSG00000196092#ENST00000414447#Paired Box#Pax2_C$#ENSP00000404687#ENSG00000196092#ENST00000446742#Paired Box#Pax2_C$#ENSP00000429291#ENSG00000196092#ENST00000520154#Paired Box#$#ENSP00000430773#ENSG00000196092#ENST00000520281#Paired Box#Pax2_C$#ENSP00000429359#ENSG00000196092#ENST00000522003#Paired Box#Pax2_C$#ENSP00000428670#ENSG00000196092#ENST00000522932#Paired Box#Pax2_C$#ENSP00000429197#ENSG00000196092#ENST00000523145#Paired Box#Pax2_C$#ENSP00000429637#ENSG00000196092#ENST00000523241#Paired Box#$#ENSP00000429404#ENSG00000196092#ENST00000524340#Paired Box#Pax2_C	FALSE
1644	ENSG00000125618	PAX8	Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001523;IPR009057;IPR022130;	7849	paired box 8 [Source:HGNC Symbol;Acc:HGNC:8622]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1508216	Yes	1a1, Direct HQ evidence	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000125618#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000125618#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9388203, PMID:9590296	$#ENSP00000263334#ENSG00000125618#ENST00000263334#Paired Box#Pax2_C$#ENSP00000263335#ENSG00000125618#ENST00000263335#Paired Box#$#ENSP00000314750#ENSG00000125618#ENST00000348715#Paired Box#$#ENSP00000380768#ENSG00000125618#ENST00000397647#Paired Box#$#ENSP00000395498#ENSG00000125618#ENST00000429538#Paired Box#Pax2_C$#ENSP00000452547#ENSG00000125618#ENST00000465084#Paired Box#Pax2_C$#ENSP00000451240#ENSG00000125618#ENST00000468980#Paired Box#Pax2_C	FALSE
1645	ENSG00000198807	PAX9	Paired box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001523;IPR009057	5083	paired box 9 [Source:HGNC Symbol;Acc:HGNC:8623]	None	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12490554;14607846	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000198807#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000355245#ENSG00000198807#ENST00000361487#Paired Box#$#ENSP00000450434#ENSG00000198807#ENST00000554201#Paired Box#$#ENSP00000384817#ENSG00000198807#ENST00000402703#Paired Box#	FALSE
1646	ENSG00000196233	LCOR	Pipsqueak	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR007889;IPR009057	84458	ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a2, Orthologous HQ evidence	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000360138#ENSG00000196233#ENST00000371097#Pipsqueak#$#ENSP00000360144#ENSG00000196233#ENST00000371103#Pipsqueak#$#ENSP00000443431#ENSG00000196233#ENST00000540664#Pipsqueak#$#ENSP00000348298#ENSG00000196233#ENST00000356016#Pipsqueak#$#ENSP00000286067#ENSG00000196233#ENST00000286067#Pipsqueak#DUF4553$#ENSP00000490116#ENSG00000196233#ENST00000421806#Pipsqueak#DUF4553	FALSE
1647	ENSG00000178177	LCORL	Pipsqueak	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR007889;IPR009057	254251	ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776]	None	Full	Yes	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000317566#ENSG00000178177#ENST00000326877#Other#$#ENSP00000371659#ENSG00000178177#ENST00000382224#Other#DUF2428$#ENSP00000371661#ENSG00000178177#ENST00000382226#Other#DUF2428$#ENSP00000490600#ENSG00000178177#ENST00000635767#Other#DUF4553	FALSE
1648	ENSG00000117707	PROX1	Prospero	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009057;IPR023082	5629	prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459]	None	DBD	not tested	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000117707#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033$#ENSG00000117707#GO:0003700#sequence-specific DNA binding transcription factor activity#IC - PMID:19210544$#ENSG00000117707#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024$#ENSG00000117707#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15205472, PMID:16488887	$#ENSP00000261454#ENSG00000117707#ENST00000261454#Homeo-prospero domain#$#ENSP00000355925#ENSG00000117707#ENST00000366958#Homeo-prospero domain#$#ENSP00000400694#ENSG00000117707#ENST00000435016#Homeo-prospero domain#$#ENSP00000420283#ENSG00000117707#ENST00000498508#Homeo-prospero domain#$#ENSP00000419517#ENSG00000117707#ENST00000471129#Homeo-prospero domain#$#ENSP00000475357#ENSG00000117707#ENST00000607425#Homeo-prospero domain#	FALSE
1649	ENSG00000119608	PROX2	Prospero	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR009057;IPR023082	283571	Prospero homeobox 2 [Source:HGNC Symbol;Acc:HGNC:26715]	None	DBD	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000119608#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000451223#ENSG00000119608#ENST00000556489#Homeo-prospero domain#$#ENSP00000451463#ENSG00000119608#ENST00000556084#Homeo-prospero domain#$#ENSP00000478947#ENSG00000119608#ENST00000619947#Homeo-prospero domain#	FALSE
1650	ENSG00000102908	NFAT5	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002909;IPR008366;IPR008967;IPR011539;IPR014756;	10725	nuclear factor of activated T-cells 5, tonicity-responsive [Source:HGNC Symbol;Acc:HGNC:7774]	1IMH	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10377394;11485737;16027109	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000102908#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11485737$#ENSG00000102908#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10051678	$#ENSP00000338806#ENSG00000102908#ENST00000349945#RHD#RHD_dimer$#ENSP00000346420#ENSG00000102908#ENST00000354436#RHD#RHD_dimer$#ENSP00000377343#ENSG00000102908#ENST00000393742#RHD#RHD_dimer$#ENSP00000455628#ENSG00000102908#ENST00000566899#RHD#RHD_dimer$#ENSP00000457593#ENSG00000102908#ENST00000567239#RHD#RHD_dimer$#ENSP00000463214#ENSG00000102908#ENST00000565301#RHD#$#ENSP00000486610#ENSG00000102908#ENST00000627621#RHD#RHD_dimer	FALSE
1651	ENSG00000131196	NFATC1	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002909;IPR008366;IPR008967;IPR011539;IPR014756;	4772	nuclear factor of activated T-cells 1 [Source:HGNC Symbol;Acc:HGNC:7775]	1A66	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:15117818;16109714	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000131196#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#ISS - GO_REF:0000024$#ENSG00000131196#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10821850, PMID:9506523$#ENSG00000131196#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000253506#ENSG00000131196#ENST00000253506#RHD#RHD_dimer, TIG$#ENSP00000316553#ENSG00000131196#ENST00000318065#RHD#RHD_dimer, TIG$#ENSP00000327850#ENSG00000131196#ENST00000329101#RHD#RHD_dimer, TIG$#ENSP00000380892#ENSG00000131196#ENST00000397790#RHD#RHD_dimer, TIG$#ENSP00000389377#ENSG00000131196#ENST00000427363#RHD#RHD_dimer, TIG$#ENSP00000442435#ENSG00000131196#ENST00000542384#RHD#RHD_dimer, TIG$#ENSP00000466489#ENSG00000131196#ENST00000586434#RHD#RHD_dimer, TIG$#ENSP00000468111#ENSG00000131196#ENST00000587635#RHD#$#ENSP00000466194#ENSG00000131196#ENST00000591814#RHD#RHD_dimer, TIG$#ENSP00000467181#ENSG00000131196#ENST00000592223#RHD#RHD_dimer, TIG$#ENSP00000439992#ENSG00000131196#ENST00000545796#RHD#RHD_dimer, TIG	FALSE
1652	ENSG00000101096	NFATC2	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	PDB:1A02 has NFAT, Fos and Jun trimeric complex with non-consensus bZIP target site	IPR002909;IPR008366;IPR008967;IPR011539;IPR014756;	4773	nuclear factor of activated T-cells 2 [Source:HGNC Symbol;Acc:HGNC:7776]	1A02	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10692237;11786533;8313907;8397339;15684054;12453415;14688323	Yes	1a1, Direct HQ evidence	Matt Weirauch	Yimeng Yin	Yes	$#ENSG00000101096#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000101096#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000101096#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8668213	$#ENSP00000360619#ENSG00000101096#ENST00000371564#RHD#RHD_dimer, TIG$#ENSP00000379330#ENSG00000101096#ENST00000396009#RHD#RHD_dimer, TIG$#ENSP00000396471#ENSG00000101096#ENST00000414705#RHD#RHD_dimer, TIG$#ENSP00000477342#ENSG00000101096#ENST00000609507#RHD#RHD_dimer, TIG$#ENSP00000477370#ENSG00000101096#ENST00000609943#RHD#RHD_dimer, TIG$#ENSP00000477142#ENSG00000101096#ENST00000610033#RHD#RHD_dimer, TIG	FALSE
1653	ENSG00000072736	NFATC3	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002909;IPR008366;IPR008967;IPR011539;IPR014756;	4775	nuclear factor of activated T-cells 3 [Source:HGNC Symbol;Acc:HGNC:7777]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7650004;7650004;11997392;15173172;7650004;15173172;15173172;16260608	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000072736#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:15173172 | IMP - PMID:15173172$#ENSG00000072736#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IGI - PMID:23543060	$#ENSP00000331324#ENSG00000072736#ENST00000329524#RHD#RHD_dimer, TIG$#ENSP00000300659#ENSG00000072736#ENST00000346183#RHD#RHD_dimer, TIG$#ENSP00000264008#ENSG00000072736#ENST00000349223#RHD#RHD_dimer, TIG$#ENSP00000456120#ENSG00000072736#ENST00000562926#RHD#RHD_dimer, TIG$#ENSP00000456379#ENSG00000072736#ENST00000570212#RHD#RHD_dimer, TIG$#ENSP00000457441#ENSG00000072736#ENST00000565750#RHD#	FALSE
1654	ENSG00000100968	NFATC4	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR002909;IPR008366;IPR008967;IPR011539;IPR014756;	4776	nuclear factor of activated T-cells 4 [Source:HGNC Symbol;Acc:HGNC:7778]	None	DBD	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11514544;11997522;16644691;17430895;16644691;12796475;16644691	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000100968#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000100968#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IGI - PMID:23543060	$#ENSP00000250373#ENSG00000100968#ENST00000250373#RHD#RHD_dimer, TIG$#ENSP00000388910#ENSG00000100968#ENST00000413692#RHD#RHD_dimer, TIG$#ENSP00000396788#ENSG00000100968#ENST00000422617#RHD#RHD_dimer, TIG$#ENSP00000388668#ENSG00000100968#ENST00000424781#RHD#RHD_dimer, TIG$#ENSP00000439350#ENSG00000100968#ENST00000539237#RHD#RHD_dimer, TIG$#ENSP00000451502#ENSG00000100968#ENST00000553469#RHD#RHD_dimer, TIG$#ENSP00000450590#ENSG00000100968#ENST00000553708#RHD#RHD_dimer, TIG$#ENSP00000451151#ENSG00000100968#ENST00000554050#RHD#RHD_dimer, TIG$#ENSP00000450469#ENSG00000100968#ENST00000554344#RHD#RHD_dimer, TIG$#ENSP00000450810#ENSG00000100968#ENST00000554473#RHD#RHD_dimer, TIG$#ENSP00000452039#ENSG00000100968#ENST00000554591#RHD#RHD_dimer, TIG$#ENSP00000450733#ENSG00000100968#ENST00000554661#RHD#RHD_dimer, TIG$#ENSP00000450644#ENSG00000100968#ENST00000554966#RHD#RHD_dimer, TIG$#ENSP00000451395#ENSG00000100968#ENST00000555167#RHD#RHD_dimer, TIG$#ENSP00000451801#ENSG00000100968#ENST00000555393#RHD#$#ENSP00000450686#ENSG00000100968#ENST00000555453#RHD#RHD_dimer, TIG$#ENSP00000451224#ENSG00000100968#ENST00000555590#RHD#RHD_dimer, TIG$#ENSP00000451590#ENSG00000100968#ENST00000555802#RHD#$#ENSP00000451454#ENSG00000100968#ENST00000556169#RHD#RHD_dimer, TIG$#ENSP00000452270#ENSG00000100968#ENST00000556279#RHD#RHD_dimer, TIG$#ENSP00000451183#ENSG00000100968#ENST00000556759#RHD#RHD_dimer, TIG$#ENSP00000451284#ENSG00000100968#ENST00000557451#RHD#RHD_dimer, TIG$#ENSP00000452349#ENSG00000100968#ENST00000553879#RHD#RHD_dimer, TIG$#ENSP00000451496#ENSG00000100968#ENST00000557767#RHD#	FALSE
1655	ENSG00000109320	NFKB1	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000451;IPR000488;IPR002110;IPR002909;IPR008967;IPR011029;IPR011539;IPR014756;IPR020683;IPR030492	4790	nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794]	1LE5	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1406630	Yes	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	Yes	$#ENSG00000109320#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:1406630$#ENSG00000109320#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:24434510$#ENSG00000109320#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17426251$#ENSG00000109320#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000226574#ENSG00000109320#ENST00000226574#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000378297#ENSG00000109320#ENST00000394820#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000424790#ENSG00000109320#ENST00000505458#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000469340#ENSG00000109320#ENST00000600343#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000424815#ENSG00000109320#ENST00000508584#RHD#RHD_dimer	FALSE
1656	ENSG00000077150	NFKB2	Rel	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000451;IPR000488;IPR002110;IPR002909;IPR008967;IPR011029;IPR011539;IPR014756;IPR020683;IPR030492	4791	nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795]	1A3Q	DBD	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8360178	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000077150#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12835724$#ENSG00000077150#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1760839, PMID:1876189$#ENSG00000077150#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000189444#ENSG00000077150#ENST00000189444#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000358983#ENSG00000077150#ENST00000369966#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000410256#ENSG00000077150#ENST00000428099#RHD#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Death, RHD_dimer$#ENSP00000471586#ENSG00000077150#ENST00000471698#RHD#	FALSE
1657	ENSG00000162924	REL	Rel	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000451;IPR002909;IPR008967;IPR011539;IPR014756;IPR030492	5966	REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954]	1GJI	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1406630	Yes	1a1, Direct HQ evidence	Laura Campitelli	Yimeng Yin	Yes	$#ENSG00000162924#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:1406630$#ENSG00000162924#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8423996	$#ENSP00000295025#ENSG00000162924#ENST00000295025#RHD#RHD_dimer$#ENSP00000377989#ENSG00000162924#ENST00000394479#RHD#RHD_dimer	FALSE
1658	ENSG00000173039	RELA	Rel	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	Can bind as a homodimer or heterodimer (PMID: 22101729). pmid:19683540 forms heterodimer with NFKB1, citation is a crystal structure	IPR000451;IPR002909;IPR008967;IPR011539;IPR014756;IPR030492	5970	RELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955]	3GUT	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1935902;15485852;15857826	Yes	1a1, Direct HQ evidence	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000173039#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IMP - PMID:26268439$#ENSG00000173039#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17350185$#ENSG00000173039#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17350185$#ENSG00000173039#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IDA - PMID:1406630$#ENSG00000173039#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:12048232$#ENSG00000173039#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:3091258$#ENSG00000173039#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15790681 | TAS - Reactome:R-HSA-445989	$#ENSP00000311508#ENSG00000173039#ENST00000308639#RHD#RHD_dimer$#ENSP00000384273#ENSG00000173039#ENST00000406246#RHD#RHD_dimer$#ENSP00000432537#ENSG00000173039#ENST00000525693#RHD#RHD_dimer$#ENSP00000431304#ENSG00000173039#ENST00000526257#RHD#$#ENSP00000483705#ENSG00000173039#ENST00000612991#RHD#RHD_dimer$#ENSP00000434098#ENSG00000173039#ENST00000533187#RHD#	FALSE
1659	ENSG00000104856	RELB	Rel	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Likely an obligate heteromer (PMID: 22101729), pmid:17869269 forms heterodimer with NFKB1, citation is a crystal structure	IPR000451;IPR002909;IPR008967;IPR011539;IPR014756;IPR030492	5971	RELB proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9956]	2V2T	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8183565;8183565;9070378	Yes	1a1, Direct HQ evidence	Matt Weirauch	Sam Lambert	Yes	$#ENSG00000104856#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000104856#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8188306	$#ENSP00000221452#ENSG00000104856#ENST00000221452#RHD#RHD_dimer, RelB_leu_zip, RelB_transactiv$#ENSP00000468460#ENSG00000104856#ENST00000589972#RHD#RelB_transactiv$#ENSP00000423287#ENSG00000104856#ENST00000505236#RHD#RHD_dimer, RelB_leu_zip, RelB_transactiv$#ENSP00000485826#ENSG00000104856#ENST00000625761#RHD#RHD_dimer, RelB_leu_zip, RelB_transactiv	FALSE
1660	ENSG00000132005	RFX1	RFX	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003150;IPR007668	5989	regulatory factor X1 [Source:HGNC Symbol;Acc:HGNC:9982]	1DP7	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:11986307;16464847	Yes	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000132005#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:8289803	$#ENSP00000254325#ENSG00000132005#ENST00000254325#RFX#RFX1_trans_act$#ENSP00000464960#ENSG00000132005#ENST00000588885#RFX#	FALSE
1661	ENSG00000087903	RFX2	RFX	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003150;IPR007668	5990	regulatory factor X2 [Source:HGNC Symbol;Acc:HGNC:9983]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8289803;16676351	Yes	1a1, Direct HQ evidence	Arttu Jolma	Yimeng Yin	Yes	$#ENSG00000087903#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000306335#ENSG00000087903#ENST00000303657#RFX#RFX1_trans_act$#ENSP00000352076#ENSG00000087903#ENST00000359161#RFX#RFX1_trans_act$#ENSP00000467166#ENSG00000087903#ENST00000592546#RFX#RFX1_trans_act$#ENSP00000467736#ENSG00000087903#ENST00000586806#RFX#$#ENSP00000465122#ENSG00000087903#ENST00000587321#RFX#$#ENSP00000466890#ENSG00000087903#ENST00000593241#RFX#RFX1_trans_act	FALSE
1662	ENSG00000080298	RFX3	RFX	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003150;IPR007668	5991	regulatory factor X3 [Source:HGNC Symbol;Acc:HGNC:9984]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000080298#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8600444$#ENSG00000080298#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:8289803	$#ENSP00000303847#ENSG00000080298#ENST00000302303#RFX#RFX1_trans_act$#ENSP00000351574#ENSG00000080298#ENST00000358730#RFX#RFX1_trans_act$#ENSP00000371434#ENSG00000080298#ENST00000382004#RFX#RFX1_trans_act$#ENSP00000482598#ENSG00000080298#ENST00000617270#RFX#RFX1_trans_act$#ENSP00000371414#ENSG00000080298#ENST00000381984#RFX#RFX1_trans_act$#ENSP00000416189#ENSG00000080298#ENST00000420720#RFX#RFX1_trans_act$#ENSP00000410988#ENSG00000080298#ENST00000442560#RFX#RFX1_trans_act$#ENSP00000399352#ENSG00000080298#ENST00000449190#RFX#RFX1_trans_act$#ENSP00000415594#ENSG00000080298#ENST00000449234#RFX#$#ENSP00000411756#ENSG00000080298#ENST00000451859#RFX#RFX1_trans_act$#ENSP00000400026#ENSG00000080298#ENST00000458034#RFX#HisKA	FALSE
1663	ENSG00000111783	RFX4	RFX	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003150;	5992	regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:11682486	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000111783#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16893423	$#ENSP00000229387#ENSG00000111783#ENST00000229387#RFX#$#ENSP00000350552#ENSG00000111783#ENST00000357881#RFX#$#ENSP00000376585#ENSG00000111783#ENST00000392842#RFX#$#ENSP00000447735#ENSG00000111783#ENST00000549040#RFX#	FALSE
1664	ENSG00000143390	RFX5	RFX	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	None	IPR003150;IPR029298	5993	regulatory factor X5 [Source:HGNC Symbol;Acc:HGNC:9986]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:9806546	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000143390#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000290524#ENSG00000143390#ENST00000290524#RFX#RFX5_DNA_bdg$#ENSP00000389130#ENSG00000143390#ENST00000452671#RFX#RFX5_DNA_bdg$#ENSP00000396810#ENSG00000143390#ENST00000412774#RFX#$#ENSP00000390769#ENSG00000143390#ENST00000436637#RFX#$#ENSP00000398666#ENSG00000143390#ENST00000450506#RFX#$#ENSP00000409187#ENSG00000143390#ENST00000458484#RFX#	FALSE
1665	ENSG00000185002	RFX6	RFX	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003150;	222546	regulatory factor X6 [Source:HGNC Symbol;Acc:HGNC:21478]	None	not tested	not tested	None	None	x	Yes	No	Yes	1a2, Orthologous HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000185002#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:20148032	$#ENSP00000332208#ENSG00000185002#ENST00000332958#RFX#	FALSE
1666	ENSG00000181827	RFX7	RFX	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003150;	64864	regulatory factor X7 [Source:HGNC Symbol;Acc:HGNC:25777]	None	DBD and Full	Yes	None	None	b	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Pratyush Das	Yes	$#ENSG00000181827#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000453611#ENSG00000181827#ENST00000560792#RFX#$#ENSP00000453281#ENSG00000181827#ENST00000559447#RFX#	FALSE
1667	ENSG00000196460	RFX8	RFX	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	RFX8 has the HUGO-approved name RFX family member 8, lacking RFX DNA binding domain?.? I cannot find the original evidence, however, and RFX8 clearly encodes a complete and high-confidence RFX DNA binding domain.? So, it seems more likely than not to be DNA binding (TRH)	None	731220	RFX family member 8, lacking RFX DNA binding domain [Source:HGNC Symbol;Acc:HGNC:37253]	None	DBD	not tested	None	None	b	Yes	No	No	1a2, Orthologous HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000196460#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000401536#ENSG00000196460#ENST00000428343#RFX#	FALSE
1668	ENSG00000159216	RUNX1	Runt	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000040;IPR008967;IPR013524;IPR013711;IPR016554;	100506403	runt related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471]	1HJC	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7609063;8035830	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000159216#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:9199349 | IMP - PMID:9199349	$#ENSP00000300305#ENSG00000159216#ENST00000300305#RUNX#RunxI$#ENSP00000340690#ENSG00000159216#ENST00000344691#RUNX#RunxI$#ENSP00000351123#ENSG00000159216#ENST00000358356#RUNX#$#ENSP00000405158#ENSG00000159216#ENST00000416754#RUNX#$#ENSP00000382184#ENSG00000159216#ENST00000399240#RUNX#RunxI$#ENSP00000388189#ENSG00000159216#ENST00000455571#RUNX#	FALSE
1669	ENSG00000124813	RUNX2	Runt	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000040;IPR008967;IPR013524;IPR013711;IPR016554;	860	runt related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11451945;16574347	Yes	1a1, Direct HQ evidence	Yimeng Yin	Jussi Taipale	Yes	$#ENSG00000124813#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000124813#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000124813#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9182765	$#ENSP00000485863#ENSG00000124813#ENST00000625924#RUNX#DUF2722, RunxI, Spt20$#ENSP00000352514#ENSG00000124813#ENST00000359524#RUNX#DUF2722, RunxI, Spt20	FALSE
1670	ENSG00000020633	RUNX3	Runt	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000040;IPR008967;IPR013524;IPR013711;IPR016554;	864	runt related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:15688019;16164020	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000020633#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024$#ENSG00000020633#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7607690	$#ENSP00000308051#ENSG00000020633#ENST00000308873#RUNX#RunxI$#ENSP00000343477#ENSG00000020633#ENST00000338888#RUNX#RunxI$#ENSP00000382800#ENSG00000020633#ENST00000399916#RUNX#RunxI	FALSE
1671	ENSG00000160224	AIRE	SAND	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds to TTATTA and tandem repeats of ATTGGTTA (PMID: 11533054)	IPR000770;IPR001965;IPR004865;IPR008087;IPR010919;IPR011011;IPR019786;IPR019787	326	autoimmune regulator [Source:HGNC Symbol;Acc:HGNC:360]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10022980;10049735;12376594;10748110;11274163;11533054;10748110;15649436;10677297;15649436	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000160224#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IC - GO_REF:0000036	$#ENSP00000291582#ENSG00000160224#ENST00000291582#SAND#HSR, PHD, PHD_2, zf-HC5HC2H	FALSE
1672	ENSG00000177030	DEAF1	SAND	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000770;IPR002893;IPR010919;	10522	DEAF1, transcription factor [Source:HGNC Symbol;Acc:HGNC:14677]	None	DBD	Yes	None	None	a	Yes	No	No	2a2, orthologous lower confidence evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000177030#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000371846#ENSG00000177030#ENST00000382409#SAND#zf-MYND	FALSE
1673	ENSG00000102393	GLA	SAND	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GLA appears to lack a functional SAND domain. It encodes a well-characterized enzyme, Galactosidase Alpha. Most of the polypeptide encodes a glycoside hydrolase domain and most of the rest encodes another pfam domain called Glycoside hydrolase family 27.  It has a low-scoring SAND domain match that almost certainly overlaps with a known domain related to its function as an enzyme.	IPR000111;IPR002241;IPR017853	2717	galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000218516#ENSG00000102393#ENST00000218516#SAND#Melibiase, Melibiase_2	FALSE
1674	ENSG00000162419	GMEB1	SAND	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000770;IPR010919	10691	glucocorticoid modulatory element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4370]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:10386584;10692587;10894151;11934901	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000162419#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000294409#ENSG00000162419#ENST00000294409#SAND#$#ENSP00000355186#ENSG00000162419#ENST00000361872#SAND#$#ENSP00000362922#ENSG00000162419#ENST00000373816#SAND#	FALSE
1675	ENSG00000101216	GMEB2	SAND	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000770;IPR010919	26205	glucocorticoid modulatory element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4371]	None	DBD	Yes	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:10894151;14705952	No	1a1, Direct HQ evidence	Laura Campitelli	Tim Hughes	Yes	None	$#ENSP00000266068#ENSG00000101216#ENST00000266068#SAND#$#ENSP00000359094#ENSG00000101216#ENST00000370077#SAND#$#ENSP00000359086#ENSG00000101216#ENST00000370069#SAND#	FALSE
1676	ENSG00000215474	SKOR2	SAND	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003380;IPR009061;IPR010919;IPR014890	652991	SKI family transcriptional corepressor 2 [Source:HGNC Symbol;Acc:HGNC:32695]	None	DBD	not tested	None	None	b	No	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	No	$#ENSG00000215474#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000383255#ENSG00000215474#ENST00000400404#SAND#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000414750#ENSG00000215474#ENST00000425639#SAND#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000483333#ENSG00000215474#ENST00000620245#SAND#Ski_Sno, c-SKI_SMAD_bind	FALSE
1677	ENSG00000067066	SP100	SAND	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Gel-shift experiments using human SP100 have shown binding to specific TTCG half sites (PMID: 11427895).	IPR000770;IPR001487;IPR001965;IPR004865;IPR009071;IPR010919;IPR011011;IPR019786;IPR019787;	6672	SP100 nuclear antigen [Source:HGNC Symbol;Acc:HGNC:11206]	None	not tested	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000067066#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15247905	$#ENSP00000264052#ENSG00000067066#ENST00000264052#HMG#HSR$#ENSP00000343023#ENSG00000067066#ENST00000340126#HMG#Bromodomain, HSR, PHD$#ENSP00000386427#ENSG00000067066#ENST00000409112#HMG#HSR$#ENSP00000386404#ENSG00000067066#ENST00000409341#HMG#HSR$#ENSP00000393679#ENSG00000067066#ENST00000431952#HMG#Bromodomain, PHD$#ENSP00000386998#ENSG00000067066#ENST00000409897#HMG#HSR$#ENSP00000399389#ENSG00000067066#ENST00000427101#HMG#HSR$#ENSP00000416563#ENSG00000067066#ENST00000452345#HMG#$#ENSP00000400277#ENSG00000067066#ENST00000413284#HMG#$#ENSP00000391616#ENSG00000067066#ENST00000432979#HMG#HSR	FALSE
1678	ENSG00000135899	SP110	SAND	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000770;IPR001487;IPR001965;IPR004865;IPR010919;IPR011011;IPR019786;IPR019787	3431	SP110 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:5401]	None	DBD and Full	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000258382#ENSG00000135899#ENST00000258382#SAND#HSR$#ENSP00000351488#ENSG00000135899#ENST00000358662#SAND#HSR, PHD$#ENSP00000375902#ENSG00000135899#ENST00000392048#SAND#HSR$#ENSP00000258381#ENSG00000135899#ENST00000258381#SAND#HSR, PHD	FALSE
1679	ENSG00000079263	SP140	SAND	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000770;IPR001487;IPR001965;IPR004865;IPR010919;IPR011011;IPR019786;IPR019787	11262	SP140 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:17133]	None	Full	Yes	None	None	x	Yes	No	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Jussi Taipale	Yes	$#ENSG00000079263#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8695863	$#ENSP00000342096#ENSG00000079263#ENST00000343805#SAND#Bromodomain, HSR, PHD$#ENSP00000362749#ENSG00000079263#ENST00000373645#SAND#HSR$#ENSP00000393618#ENSG00000079263#ENST00000417495#SAND#Bromodomain, HSR, PHD$#ENSP00000398210#ENSG00000079263#ENST00000420434#SAND#Bromodomain, HSR, PHD$#ENSP00000375899#ENSG00000079263#ENST00000392045#SAND#Bromodomain, HSR, PHD	FALSE
1680	ENSG00000185404	SP140L	SAND	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR000770;IPR001487;IPR001965;IPR004865;IPR010919;IPR011011;IPR019786;IPR019787	93349	SP140 nuclear body protein like [Source:HGNC Symbol;Acc:HGNC:25105]	None	DBD	not tested	None	None	b	Yes	No	No	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	Yes	None	$#ENSP00000243810#ENSG00000185404#ENST00000243810#SAND#Bromodomain, HSR, PHD$#ENSP00000379811#ENSG00000185404#ENST00000396563#SAND#Bromodomain, HSR, PHD$#ENSP00000395223#ENSG00000185404#ENST00000458341#SAND#HSR	FALSE
1681	ENSG00000175467	SART1	SART-1	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely an RNA-binding protein	IPR005011;	9092	squamous cell carcinoma antigen recognized by T-cells 1 [Source:HGNC Symbol;Acc:HGNC:10538]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000310448#ENSG00000175467#ENST00000312397#SART-1#	FALSE
1682	ENSG00000241343	RPL36A	SBP	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ribosomal component	IPR000552;IPR011332	6173	ribosomal protein L36a [Source:HGNC Symbol;Acc:HGNC:10359]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$#ENSP00000404375#ENSG00000241343#ENST00000427805#SBP#$#ENSP00000446503#ENSG00000241343#ENST00000553110#SBP#Ribosomal_L44$#ENSP00000483017#ENSG00000241343#ENST00000614077#SBP#$#ENSP00000397659#ENSG00000241343#ENST00000392994#SBP#Ribosomal_L44$#ENSP00000473451#ENSG00000241343#ENST00000471855#SBP#	FALSE
1683	ENSG00000162599	NFIA	SMAD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000647;IPR003619;IPR019548;IPR019739;IPR020604;	4774	nuclear factor I A [Source:HGNC Symbol;Acc:HGNC:7784]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:16169882;17010934	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000162599#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:17010934$#ENSG00000162599#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7590749	$#ENSP00000360229#ENSG00000162599#ENST00000371187#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000384523#ENSG00000162599#ENST00000403491#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000474817#ENSG00000162599#ENST00000493627#MH1 Family DBDs#CTF_NFI$#ENSP00000474462#ENSG00000162599#ENST00000357977#MH1 Family DBDs#CTF_NFI$#ENSP00000360231#ENSG00000162599#ENST00000371189#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000384680#ENSG00000162599#ENST00000407417#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000474461#ENSG00000162599#ENST00000476646#MH1 Family DBDs#CTF_NFI$#ENSP00000474806#ENSG00000162599#ENST00000482020#MH1 Family DBDs#CTF_NFI$#ENSP00000473830#ENSG00000162599#ENST00000496712#MH1 Family DBDs#	FALSE
1684	ENSG00000147862	NFIB	SMAD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000647;IPR003619;IPR019548;IPR019739;IPR020604;	4781	nuclear factor I B [Source:HGNC Symbol;Acc:HGNC:7785]	None	DBD and Full	Yes	None	None	a	Yes	No	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000147862#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:19540848, PMID:9099724$#ENSG00000147862#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19540848	$#ENSP00000370308#ENSG00000147862#ENST00000380921#MH1 Family DBDs#NfI_DNAbd_pre-N$#ENSP00000370340#ENSG00000147862#ENST00000380953#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000370346#ENSG00000147862#ENST00000380959#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000442888#ENSG00000147862#ENST00000543693#MH1 Family DBDs#CTF_NFI$#ENSP00000370321#ENSG00000147862#ENST00000380934#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000380705#ENSG00000147862#ENST00000397575#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000475362#ENSG00000147862#ENST00000493697#MH1 Family DBDs#NfI_DNAbd_pre-N$#ENSP00000475813#ENSG00000147862#ENST00000606230#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490945#ENSG00000147862#ENST00000635877#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490762#ENSG00000147862#ENST00000636057#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000489634#ENSG00000147862#ENST00000636063#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490588#ENSG00000147862#ENST00000636432#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490864#ENSG00000147862#ENST00000636735#MH1 Family DBDs#CTF_NFI$#ENSP00000490020#ENSG00000147862#ENST00000637640#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000490950#ENSG00000147862#ENST00000637742#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N	FALSE
1685	ENSG00000141905	NFIC	SMAD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000647;IPR003619;IPR019548;IPR019739;IPR020604;	4782	nuclear factor I C [Source:HGNC Symbol;Acc:HGNC:7786]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2504497	Yes	1a1, Direct HQ evidence	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000141905#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:1524678$#ENSG00000141905#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:1524678	$#ENSP00000342194#ENSG00000141905#ENST00000341919#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000465655#ENSG00000141905#ENST00000589123#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000378543#ENSG00000141905#ENST00000395111#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000396843#ENSG00000141905#ENST00000443272#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000466647#ENSG00000141905#ENST00000590282#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N	FALSE
1686	ENSG00000008441	NFIX	SMAD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000647;IPR003619;IPR019548;IPR019739;IPR020604;	4784	nuclear factor I X [Source:HGNC Symbol;Acc:HGNC:7788]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9660824;9822643	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000008441#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7590749, PMID:8340106$#ENSG00000008441#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:7937100	$#ENSP00000380781#ENSG00000008441#ENST00000397661#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000467785#ENSG00000008441#ENST00000587260#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000466389#ENSG00000008441#ENST00000587760#MH1 Family DBDs#CTF_NFI, NfI_DNAbd_pre-N$#ENSP00000466735#ENSG00000008441#ENST00000588228#MH1 Family DBDs#CTF_NFI$#ENSP00000465616#ENSG00000008441#ENST00000590027#MH1 Family DBDs#$#ENSP00000468707#ENSG00000008441#ENST00000586873#MH1 Family DBDs#$#ENSP00000465094#ENSG00000008441#ENST00000591028#MH1 Family DBDs#NfI_DNAbd_pre-N	FALSE
1687	ENSG00000170365	SMAD1	SMAD	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Well-established obligate heteromer	IPR001132;IPR003619;IPR008984;IPR013019	4086	SMAD family member 1 [Source:HGNC Symbol;Acc:HGNC:6767]	3KMP	DBD and Full	not tested	None	3KMP is a homodimer	a	Yes	No	Yes	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000170365#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:12270938$#ENSG00000170365#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9389648	$#ENSP00000305769#ENSG00000170365#ENST00000302085#MH1 Family DBDs#IRF-3, MH2$#ENSP00000377652#ENSG00000170365#ENST00000394092#MH1 Family DBDs#IRF-3, MH2$#ENSP00000427002#ENSG00000170365#ENST00000512019#MH1 Family DBDs#$#ENSP00000425270#ENSG00000170365#ENST00000514831#MH1 Family DBDs#$#ENSP00000426568#ENSG00000170365#ENST00000515385#MH1 Family DBDs#IRF-3, MH2$#ENSP00000421601#ENSG00000170365#ENST00000507367#MH1 Family DBDs#	FALSE
1688	ENSG00000175387	SMAD2	SMAD	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	A 30 amino-acid insertion encoded by exon 3 is thought to displace the hairpin loop, providing a structural explanation for SMAD2s lack of DNA-binding activity (PMID: 11532220).	IPR001132;IPR003619;IPR008984;IPR013019	4087	SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768]	None	DBD	not tested	Heterodimerizes with SMAD4	pmid: PMID: 16322555, a review SMAD[1235] are supposed to be SMAD:s that bind DNA with SMAD4 as heteromultimers	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000175387#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9389648$#ENSG00000175387#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17438144, PMID:9389648	$#ENSP00000262160#ENSG00000175387#ENST00000262160#MH1 Family DBDs#IRF-3, MH2$#ENSP00000349282#ENSG00000175387#ENST00000356825#MH1 Family DBDs#IRF-3, MH2$#ENSP00000384449#ENSG00000175387#ENST00000402690#MH1 Family DBDs#IRF-3, MH2$#ENSP00000467075#ENSG00000175387#ENST00000591214#MH1 Family DBDs#IRF-3, MH2$#ENSP00000468732#ENSG00000175387#ENST00000585978#MH1 Family DBDs#$#ENSP00000466254#ENSG00000175387#ENST00000587269#MH1 Family DBDs#$#ENSP00000465971#ENSG00000175387#ENST00000589877#MH1 Family DBDs#	FALSE
1689	ENSG00000166949	SMAD3	SMAD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001132;IPR003619;IPR008984;IPR013019	4088	SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769]	1MHD	DBD and Full	Yes	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9660945	Yes	1a1, Direct HQ evidence	Matt Weirauch	Arttu Jolma	Yes	$#ENSG00000166949#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IDA - PMID:21947082 | IMP - PMID:26311719$#ENSG00000166949#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10823886, PMID:21947082, PMID:9111321,	$#ENSP00000332973#ENSG00000166949#ENST00000327367#MH1 Family DBDs#IRF-3, MH2$#ENSP00000401133#ENSG00000166949#ENST00000439724#MH1 Family DBDs#IRF-3, MH2$#ENSP00000445348#ENSG00000166949#ENST00000537194#MH1 Family DBDs#IRF-3, MH2$#ENSP00000437757#ENSG00000166949#ENST00000540846#MH1 Family DBDs#IRF-3, MH2$#ENSP00000453684#ENSG00000166949#ENST00000558739#MH1 Family DBDs#$#ENSP00000455540#ENSG00000166949#ENST00000560424#MH1 Family DBDs#MH2	FALSE
1690	ENSG00000141646	SMAD4	SMAD	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None	IPR001132;IPR003619;IPR008984;IPR013019	4089	SMAD family member 4 [Source:HGNC Symbol;Acc:HGNC:6770]	3QSV	DBD and Full	Yes	None	3QSV is a homodimeric complex	a	Yes	No	Yes	1a1, Direct HQ evidence	Yimeng Yin	Matt Weirauch	Yes	$#ENSG00000141646#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9389648$#ENSG00000141646#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10823886, PMID:17438144	$#ENSP00000465874#ENSG00000141646#ENST00000589941#MH1 Family DBDs#$#ENSP00000466941#ENSG00000141646#ENST00000591914#MH1 Family DBDs#$#ENSP00000466118#ENSG00000141646#ENST00000593223#MH1 Family DBDs#MH2	FALSE
1691	ENSG00000113658	SMAD5	SMAD	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001132;IPR003619;IPR008984;IPR013019	4090	SMAD family member 5 [Source:HGNC Symbol;Acc:HGNC:6771]	4ZKG	DBD and Full	not tested	None	None	a	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11527422	No	1a1, Direct HQ evidence	Arttu Jolma	Laura Campitelli	Yes	$#ENSG00000113658#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000425749#ENSG00000113658#ENST00000507118#MH1 Family DBDs#$#ENSP00000426696#ENSG00000113658#ENST00000509297#MH1 Family DBDs#$#ENSP00000424279#ENSG00000113658#ENST00000511116#MH1 Family DBDs#$#ENSP00000427330#ENSG00000113658#ENST00000515005#MH1 Family DBDs#$#ENSP00000441954#ENSG00000113658#ENST00000545279#MH1 Family DBDs#IRF-3, MH2$#ENSP00000427474#ENSG00000113658#ENST00000507637#MH1 Family DBDs#MH2	FALSE
1692	ENSG00000137834	SMAD6	SMAD	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	In the inhibitory Smads, Smad6 and Smad7 and DAD, the MH1 domains are replaced by divergent amino-termini that share regions of similarity within the inhibitory Smad subgroup (PMID: 11532220).	IPR001132;IPR003619;IPR008984;IPR013019	4091	SMAD family member 6 [Source:HGNC Symbol;Acc:HGNC:6772]	None	Full	not tested	None	pmid: PMID: 16322555, a review SMAD[67] are supposed to be inhibitory SMAD:s that lack ability to bind DNA, but instead sequester RSMADs (SMAD[1235]) into non DNA-binding complexes instead of binding DNA with SMAD4	x	Yes	No	No	2a1, Lower confidence direct evidence	Jussi Taipale	Pratyush Das	Yes	$#ENSG00000137834#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000288840#ENSG00000137834#ENST00000288840#MH1 Family DBDs#MH2$#ENSP00000452694#ENSG00000137834#ENST00000558937#MH1 Family DBDs#	FALSE
1693	ENSG00000101665	SMAD7	SMAD	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	In the inhibitory Smads, Smad6 and Smad7 and DAD, the MH1 domains are replaced by divergent amino-termini that share regions of similarity within the inhibitory Smad subgroup (PMID: 11532220).	IPR001132;IPR003619;IPR008984;IPR013019	4092	SMAD family member 7 [Source:HGNC Symbol;Acc:HGNC:6773]	None	Full	not tested	None	pmid: PMID: 16322555, a review SMAD[67] are supposed to be inhibitory SMAD:s that lack ability to bind DNA, but instead sequester RSMADs (SMAD[1235]) into non DNA-binding complexes instead of binding DNA with SMAD4	x	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12408818	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000101665#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002$#ENSG00000101665#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:17438144	$#ENSP00000262158#ENSG00000101665#ENST00000262158#MH1 Family DBDs#MH2$#ENSP00000465590#ENSG00000101665#ENST00000586093#MH1 Family DBDs#MH2$#ENSP00000466902#ENSG00000101665#ENST00000591805#MH1 Family DBDs#MH2$#ENSP00000467621#ENSG00000101665#ENST00000589634#MH1 Family DBDs#MH2	FALSE
1694	ENSG00000120693	SMAD9	SMAD	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001132;IPR003619;IPR008984;IPR013019	4093	SMAD family member 9 [Source:HGNC Symbol;Acc:HGNC:6774]	None	DBD and Full	not tested	Heterodimerizes with SMAD4	pmid: PMID: 16322555, a review SMAD[1235] are supposed to be SMAD:s that bind DNA with SMAD4 as heteromultimers	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation_PMIDS:10814522;11163184	No	2a1, Lower confidence direct evidence	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000120693#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000239885#ENSG00000120693#ENST00000350148#MH1 Family DBDs#IRF-3, MH2$#ENSP00000382216#ENSG00000120693#ENST00000399275#MH1 Family DBDs#IRF-3, MH2$#ENSP00000369154#ENSG00000120693#ENST00000379826#MH1 Family DBDs#IRF-3, MH2	FALSE
1695	ENSG00000115415	STAT1	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	Structure PDB:1BF5 is Tyrosine phosphorylated	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988;IPR022752;	6772	signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362]	1BF5	DBD and Full	not tested	Requires_Phosphorylation	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:10820245;12859963	Yes	1a1, Direct HQ evidence	Tim Hughes	Jussi Taipale	Yes	$#ENSG00000115415#GO:0000983#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity#IDA - PMID:21268089$#ENSG00000115415#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:10973496	$#ENSP00000354394#ENSG00000115415#ENST00000361099#STAT#SH2, STAT1_TAZ2bind, STAT_alpha, STAT_int$#ENSP00000376136#ENSG00000115415#ENST00000392322#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000386244#ENSG00000115415#ENST00000409465#STAT#SH2, STAT1_TAZ2bind, STAT_alpha, STAT_int$#ENSP00000376137#ENSG00000115415#ENST00000392323#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000402548#ENSG00000115415#ENST00000424722#STAT#STAT_alpha, STAT_int	FALSE
1696	ENSG00000170581	STAT2	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988;IPR022756;	6773	signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363]	None	DBD and Full	not tested	Requires_Phosphorylation	None	a	Yes	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000170581#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000315768#ENSG00000170581#ENST00000314128#STAT#SH2, STAT2_C, STAT_alpha, STAT_int$#ENSP00000387354#ENSG00000170581#ENST00000418572#STAT#STAT_alpha, STAT_int$#ENSP00000450751#ENSG00000170581#ENST00000557235#STAT#SH2, STAT2_C, STAT_alpha, STAT_int	FALSE
1697	ENSG00000168610	STAT3	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988	6774	signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364]	1BG1	DBD and Full	not tested	Requires_Phosphorylation	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8530402;10458605	Yes	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000168610#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:16946298$#ENSG00000168610#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16835372$#ENSG00000168610#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:17344214$#ENSG00000168610#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:17324931	$#ENSP00000264657#ENSG00000168610#ENST00000264657#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000384943#ENSG00000168610#ENST00000404395#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000467985#ENSG00000168610#ENST00000588969#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000373923#ENSG00000168610#ENST00000389272#STAT#SH2, STAT_alpha	FALSE
1698	ENSG00000138378	STAT4	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015155;IPR015988;	6775	signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:HGNC:11365]	None	DBD and Full	not tested	Requires_Phosphorylation	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12372421;17304212	Yes	1a1, Direct HQ evidence	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000138378#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000351255#ENSG00000138378#ENST00000358470#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000376134#ENSG00000138378#ENST00000392320#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000412397#ENSG00000138378#ENST00000450994#STAT#STAT_int	FALSE
1699	ENSG00000126561	STAT5A	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988	6776	signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366]	None	DBD and Full	not tested	Requires_Phosphorylation	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12393611	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Yimeng Yin	Yes	$#ENSG00000126561#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000341208#ENSG00000126561#ENST00000345506#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000443107#ENSG00000126561#ENST00000546010#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000466320#ENSG00000126561#ENST00000587646#STAT#SH2$#ENSP00000465437#ENSG00000126561#ENST00000588868#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000468749#ENSG00000126561#ENST00000590949#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000464730#ENSG00000126561#ENST00000590726#STAT#STAT_alpha	FALSE
1700	ENSG00000173757	STAT5B	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Can form both homodimers and heterodimers with STAT5A (PMID: 9528750)	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988	6777	signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:HGNC:11367]	None	DBD	not tested	Requires_Phosphorylation	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9852045;12050218	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000173757#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000173757#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8631883	$#ENSP00000293328#ENSG00000173757#ENST00000293328#STAT#SH2, STAT_alpha, STAT_int$#ENSP00000398379#ENSG00000173757#ENST00000415845#STAT#STAT_int, TerB_N	FALSE
1701	ENSG00000166888	STAT6	STAT	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000980;IPR008967;IPR013799;IPR013800;IPR013801;IPR015988;IPR028187;	6778	signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368]	4Y5W	DBD and Full	not tested	Requires_Phosphorylation	Requires phosphorylation	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7760829;8810328	Yes	1a1, Direct HQ evidence	Pratyush Das	Jussi Taipale	Yes	$#ENSG00000166888#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000300134#ENSG00000166888#ENST00000300134#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000451742#ENSG00000166888#ENST00000556155#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000401486#ENSG00000166888#ENST00000454075#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000444530#ENSG00000166888#ENST00000537215#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000445409#ENSG00000166888#ENST00000538913#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000438451#ENSG00000166888#ENST00000543873#STAT#SH2, STAT6_C, STAT_alpha$#ENSP00000450732#ENSG00000166888#ENST00000553275#STAT#STAT_int$#ENSP00000451546#ENSG00000166888#ENST00000553533#STAT#SH2$#ENSP00000450428#ENSG00000166888#ENST00000555318#STAT#STAT6_C$#ENSP00000450921#ENSG00000166888#ENST00000555375#STAT#SH2$#ENSP00000452373#ENSG00000166888#ENST00000556259#STAT#STAT_int	FALSE
1702	ENSG00000163508	EOMES	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	8320	eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372]	None	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:8978604;11585801	No	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000163508#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000295743#ENSG00000163508#ENST00000295743#T-box#T-box_assoc$#ENSP00000388620#ENSG00000163508#ENST00000449599#T-box#T-box_assoc$#ENSP00000487112#ENSG00000163508#ENST00000461503#T-box#T-box_assoc	FALSE
1703	ENSG00000174197	MGA	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	Has a putative AT-hook	Some isoforms also contain a predicted bHLH domain, but it is unlike any other known bHLH domain and the MGA motif looks like a standard T-box motif, so the bHLH domain is likely a false positive	IPR001699;IPR008967;IPR011598;IPR018186	23269	MGA, MAX dimerization protein [Source:HGNC Symbol;Acc:HGNC:14010]	None	DBD	Yes	None	None	b	Yes	No	No	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000174197#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000457151#ENSG00000174197#ENST00000563576#T-box#DUF4801$#ENSP00000456141#ENSG00000174197#ENST00000566586#T-box#DUF4801$#ENSP00000483990#ENSG00000174197#ENST00000619521#T-box#$#ENSP00000457474#ENSG00000174197#ENST00000564190#T-box#$#ENSP00000455155#ENSG00000174197#ENST00000566718#T-box#DUF4801	FALSE
1704	ENSG00000164458	T	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR002070;IPR008967;IPR018186	6862	T brachyury transcription factor [Source:HGNC Symbol;Acc:HGNC:11515]	1XBR	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:7588606;8344258	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000164458#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8963900$#ENSG00000164458#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IDA - PMID:21632880	$#ENSP00000355836#ENSG00000164458#ENST00000366871#T-box#$#ENSP00000355841#ENSG00000164458#ENST00000366876#T-box#$#ENSP00000296946#ENSG00000164458#ENST00000296946#T-box#$#ENSP00000453512#ENSG00000164458#ENST00000461348#T-box#	FALSE
1705	ENSG00000136535	TBR1	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	10716	T-box, brain 1 [Source:HGNC Symbol;Acc:HGNC:11590]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:10749215;11239428;15634788	Yes	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000136535#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000374205#ENSG00000136535#ENST00000389554#T-box#T-box_assoc$#ENSP00000387023#ENSG00000136535#ENST00000410035#T-box#T-box_assoc$#ENSP00000393934#ENSG00000136535#ENST00000411412#T-box#T-box_assoc	FALSE
1706	ENSG00000184058	TBX1	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	6899	T-box 1 [Source:HGNC Symbol;Acc:HGNC:11592]	4A04	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11111039;15736267	No	1a1, Direct HQ evidence	Jussi Taipale	Laura Campitelli	Yes	$#ENSG00000184058#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11111039	$#ENSP00000331176#ENSG00000184058#ENST00000329705#T-box#$#ENSP00000331791#ENSG00000184058#ENST00000332710#T-box#$#ENSP00000352483#ENSG00000184058#ENST00000359500#T-box#$#ENSP00000477982#ENSG00000184058#ENST00000621939#T-box#	FALSE
1707	ENSG00000167800	TBX10	T-box	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	347853	T-box 10 [Source:HGNC Symbol;Acc:HGNC:11593]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a2, Orthologous HQ evidence	Pratyush Das	Yimeng Yin	Yes	$#ENSG00000167800#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000335191#ENSG00000167800#ENST00000335385#T-box#	FALSE
1708	ENSG00000092607	TBX15	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	6913	T-box 15 [Source:HGNC Symbol;Acc:HGNC:11594]	None	DBD and Full	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000092607#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000207157#ENSG00000092607#ENST00000207157#T-box#$#ENSP00000358437#ENSG00000092607#ENST00000369429#T-box#$#ENSP00000398625#ENSG00000092607#ENST00000449873#T-box#	FALSE
1709	ENSG00000112837	TBX18	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	9096	T-box 18 [Source:HGNC Symbol;Acc:HGNC:11595]	None	DBD and Full	not tested	None	None	b	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	1a1, Direct HQ evidence	Pratyush Das	Matt Weirauch	Yes	$#ENSG00000112837#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000358677#ENSG00000112837#ENST00000369663#T-box#$#ENSP00000475873#ENSG00000112837#ENST00000606784#T-box#$#ENSP00000476137#ENSG00000112837#ENST00000606621#T-box#$#ENSP00000475498#ENSG00000112837#ENST00000606325#T-box#	FALSE
1710	ENSG00000143178	TBX19	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR002070;IPR008967;IPR018186	9095	T-box 19 [Source:HGNC Symbol;Acc:HGNC:11596]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11290323	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000143178#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000356795#ENSG00000143178#ENST00000367821#T-box#$#ENSP00000390731#ENSG00000143178#ENST00000441464#T-box#$#ENSP00000397540#ENSG00000143178#ENST00000431969#T-box#	FALSE
1711	ENSG00000121068	TBX2	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR002070;IPR008967;IPR018186;IPR022582;	6909	T-box 2 [Source:HGNC Symbol;Acc:HGNC:11597]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11111039	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000121068#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11111039	$#ENSP00000240328#ENSG00000121068#ENST00000240328#T-box#TBX	FALSE
1712	ENSG00000164532	TBX20	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	57057	T-box 20 [Source:HGNC Symbol;Acc:HGNC:11598]	None	DBD and Full	Yes	None	None	b	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15843407	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000164532#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000386170#ENSG00000164532#ENST00000408931#T-box#	FALSE
1713	ENSG00000073861	TBX21	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	30009	T-box 21 [Source:HGNC Symbol;Acc:HGNC:11599]	None	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10761931;15662016;16275766	Yes	1a1, Direct HQ evidence	Jussi Taipale	Tim Hughes	Yes	$#ENSG00000073861#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10761931	$#ENSP00000177694#ENSG00000073861#ENST00000177694#T-box#	FALSE
1714	ENSG00000122145	TBX22	T-box	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None	IPR001699;IPR008967;IPR018186;	50945	T-box 22 [Source:HGNC Symbol;Acc:HGNC:11600]	None	DBD and Full	not tested	None	None	b	Yes	TF Gene Candidate__Other_PMIDS:12374769	No	2a1, Lower confidence direct evidence	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000122145#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:11024289	$#ENSP00000362390#ENSG00000122145#ENST00000373294#T-box#$#ENSP00000362393#ENSG00000122145#ENST00000373296#T-box#	FALSE
1715	ENSG00000135111	TBX3	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR002070;IPR008967;IPR018186;IPR022582;	6926	T-box 3 [Source:HGNC Symbol;Acc:HGNC:11602]	1H6F	DBD and Full	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11689487;12005433	Yes	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000135111#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11689487	$#ENSP00000257566#ENSG00000135111#ENST00000257566#T-box#TBX$#ENSP00000257567#ENSG00000135111#ENST00000349155#T-box#TBX	FALSE
1716	ENSG00000121075	TBX4	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Available motifs suggest facultative homodimeric binding	IPR001699;IPR002070;IPR008967;IPR018186	9496	T-box 4 [Source:HGNC Symbol;Acc:HGNC:11603]	None	DBD and Full	Yes	None	None	a	Yes	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0;	Yes	1a1, Direct HQ evidence	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000121075#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10945475	$#ENSP00000240335#ENSG00000121075#ENST00000240335#T-box#$#ENSP00000377435#ENSG00000121075#ENST00000393853#T-box#$#ENSP00000467588#ENSG00000121075#ENST00000589003#T-box#	FALSE
1717	ENSG00000089225	TBX5	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR008967;IPR018186;	6910	T-box 5 [Source:HGNC Symbol;Acc:HGNC:11604]	2X6V	DBD	Yes	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11555635	Yes	1a1, Direct HQ evidence	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000089225#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000089225#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11431700, PMID:12499378, PMID:16332960	$#ENSP00000309913#ENSG00000089225#ENST00000310346#T-box#$#ENSP00000337723#ENSG00000089225#ENST00000349716#T-box#$#ENSP00000384152#ENSG00000089225#ENST00000405440#T-box#$#ENSP00000433292#ENSG00000089225#ENST00000526441#T-box#	FALSE
1718	ENSG00000149922	TBX6	T-box	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR001699;IPR002070;IPR008967;IPR018186	6911	T-box 6 [Source:HGNC Symbol;Acc:HGNC:11605]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15986483	No	1a1, Direct HQ evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000149922#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000279386#ENSG00000149922#ENST00000279386#T-box#$#ENSP00000378650#ENSG00000149922#ENST00000395224#T-box#$#ENSP00000461223#ENSG00000149922#ENST00000553607#T-box#$#ENSP00000485762#ENSG00000149922#ENST00000627355#T-box#	FALSE
1719	ENSG00000112592	TBP	TBP	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	Binds DNA in the pre-initiation complex	IPR000814;IPR030491	6908	TATA-box binding protein [Source:HGNC Symbol;Acc:HGNC:11588]	1CDW	not tested	Yes	None	None	No	Yes	No	No	1a1, Direct HQ evidence	Arttu Jolma	Sam Lambert	Yes	$#ENSG00000112592#GO:0001034#sequence-specific DNA binding RNA polymerase III transcription factor activity#IMP - PMID:26638071	$#ENSP00000230354#ENSG00000112592#ENST00000230354#TBP#DDHD, DUF4746, EPL1, MMR1, Presenilin$#ENSP00000375942#ENSG00000112592#ENST00000392092#TBP#DDHD, DUF4746, EPL1, MMR1, Presenilin$#ENSP00000400008#ENSG00000112592#ENST00000421512#TBP#DDHD, DUF4746, EPL1, MMR1, Presenilin, SpoIIP, TFI$#ENSP00000442132#ENSG00000112592#ENST00000540980#TBP#DDHD, EPL1, MMR1, Presenilin$#ENSP00000416482#ENSG00000112592#ENST00000423353#TBP#DUF4746, SpoIIP, TFIIA	FALSE
1720	ENSG00000028839	TBPL1	TBP	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	A more distant paralog of TBP and the only member of the TBP family that lacks the ability to bind the TATA box. (PMID: 21711503). In vitro, purified TLF-TFIIA binds directly to the NF1 promoter (PMID: 15767669), so likely an obligate heteromer.	IPR000814;	9519	TATA-box binding protein like 1 [Source:HGNC Symbol;Acc:HGNC:11589]	None	not tested	Yes	None	None	No	Yes	TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:11352070;15767669	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Tim Hughes	Yes	None	$#ENSP00000237264#ENSG00000028839#ENST00000237264#TBP#$#ENSP00000356845#ENSG00000028839#ENST00000367871#TBP#$#ENSP00000478795#ENSG00000028839#ENST00000613034#TBP#$#ENSP00000356843#ENSG00000028839#ENST00000367869#TBP#$#ENSP00000402864#ENSG00000028839#ENST00000416965#TBP#	FALSE
1721	ENSG00000182521	TBPL2	TBP	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000814;IPR030491	387332	TATA-box binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:19841]	None	not tested	not tested	None	None	No	Yes	No	No	1a2, Orthologous HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000182521#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000247219#ENSG00000182521#ENST00000247219#TBP#$#ENSP00000451597#ENSG00000182521#ENST00000556755#TBP#	FALSE
1722	ENSG00000189308	LIN54	TCR/CxC	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	In the structure (PDB: 5FD3), the protein contacts DNA, although it only contacts the backbone except for one tyrosine residue	IPR005172;	132660	lin-54 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:25397]	5FD3	not tested	not tested	None	Structure appears to contact essentially only the backbone except for one tyrosine residue, presumably non- or low specificity interaction	No	Yes	No	No	3a, decent circumstantial evidence for its role as	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000341947#ENSG00000189308#ENST00000340417#CxC#$#ENSP00000398265#ENSG00000189308#ENST00000442461#CxC#$#ENSP00000407139#ENSG00000189308#ENST00000446851#CxC#$#ENSP00000423475#ENSG00000189308#ENST00000506560#CxC#$#ENSP00000421045#ENSG00000189308#ENST00000510557#CxC#	FALSE
1723	ENSG00000132749	TESMIN	TCR/CxC	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Has a double CxC DBD structure.  One is eroded, and it did not produce a motif on PBMs.  So, either it has lost its ability to bind DNA, or the experiment failed for some reason.	IPR005172;	9633	testis expressed metallothionein like protein [Source:HGNC Symbol;Acc:HGNC:7446]	None	not tested	Yes	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	No	None	$#ENSP00000255087#ENSG00000132749#ENST00000255087#CxC#$#ENSP00000440968#ENSG00000132749#ENST00000544963#CxC#$#ENSP00000403086#ENSG00000132749#ENST00000443940#CxC#$#ENSP00000454311#ENSG00000132749#ENST00000543240#CxC#	FALSE
1724	ENSG00000110244	APOA4	TEA	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	APOA4 is Apolipoprotein A4. It consists entirely of Apolipoprotein A1/A4/E domains. The protein product is excluded from the nucleus. I cant see that it has a TEA domain. I believe it is likely to be a low-scoring domain match that almost certainly overlaps with a known domain related to its function as an enzyme. Thus it is unlikely to be a DNA binding protein.	IPR000074	337	apolipoprotein A4 [Source:HGNC Symbol;Acc:HGNC:602]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	None	$#ENSP00000350425#ENSG00000110244#ENST00000357780#TEA#ApoLp-III, ApoO, Baculo_PEP_C, DUF1664, KapB	FALSE
1725	ENSG00000187079	TEAD1	TEA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000818;IPR016361	7003	TEA domain transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11714]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Jussi Taipale	Sam Lambert	Yes	$#ENSG00000187079#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:26045994$#ENSG00000187079#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877	$#ENSP00000334754#ENSG00000187079#ENST00000334310#TEA#$#ENSP00000435393#ENSG00000187079#ENST00000526600#TEA#$#ENSP00000435233#ENSG00000187079#ENST00000527636#TEA#$#ENSP00000432587#ENSG00000187079#ENST00000527376#TEA#	FALSE
1726	ENSG00000074219	TEAD2	TEA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000818;IPR016361	8463	TEA domain transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11715]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11279002	Yes	1a1, Direct HQ evidence	Laura Campitelli	Jussi Taipale	Yes	$#ENSG00000074219#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877 | NAS - PMID:87$#ENSG00000074219#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000310701#ENSG00000074219#ENST00000311227#TEA#$#ENSP00000469640#ENSG00000074219#ENST00000593945#TEA#$#ENSP00000472109#ENSG00000074219#ENST00000598810#TEA#$#ENSP00000469672#ENSG00000074219#ENST00000601519#TEA#$#ENSP00000366419#ENSG00000074219#ENST00000377214#TEA#$#ENSP00000437928#ENSG00000074219#ENST00000539846#TEA#	FALSE
1727	ENSG00000007866	TEAD3	TEA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000818;IPR016361;IPR027253;	7005	TEA domain transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11716]	None	DBD and Full	not tested	None	None	a	Yes	No	No	1a1, Direct HQ evidence	Yimeng Yin	Pratyush Das	Yes	$#ENSG00000007866#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877	$#ENSP00000345772#ENSG00000007866#ENST00000338863#TEA#$#ENSP00000384577#ENSG00000007866#ENST00000402886#TEA#$#ENSP00000416400#ENSG00000007866#ENST00000433586#TEA#	FALSE
1728	ENSG00000197905	TEAD4	TEA	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR000818;IPR016361;IPR027255;	7004	TEA domain transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11717]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8631987	No	1a1, Direct HQ evidence	Jussi Taipale	Arttu Jolma	Yes	$#ENSG00000197905#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:18579750, PMID:19324877	$#ENSP00000351184#ENSG00000197905#ENST00000358409#TEA#$#ENSP00000352926#ENSG00000197905#ENST00000359864#TEA#$#ENSP00000380311#ENSG00000197905#ENST00000397122#TEA#	FALSE
1729	ENSG00000131931	THAP1	THAP finger	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	Likely binds as a homodimer	IPR006612;	55145	THAP domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20856]	2KO0	not tested	not tested	None	None	c	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000254250#ENSG00000131931#ENST00000254250#THAP#ADIP, APG6, ATG16, CENP-Q, Cep57_CLD, DUF4391, MPS$#ENSP00000344966#ENSG00000131931#ENST00000345117#THAP#$#ENSP00000433912#ENSG00000131931#ENST00000529779#THAP#	FALSE
1730	ENSG00000129028	THAP10	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Paralog THAP1 binds DNA in a sequence specific manner	IPR006612;	56906	THAP domain containing 10 [Source:HGNC Symbol;Acc:HGNC:23193]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Matt Weirauch	Yes	None	$#ENSP00000249861#ENSG00000129028#ENST00000249861#THAP#$#ENSP00000453920#ENSG00000129028#ENST00000560604#THAP#	FALSE
1731	ENSG00000168286	THAP11	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	(PMID: 26876175) has a ChIP-seq motif with  GGGARWTGTAGT consensus. THAP11 is an atypical zinc-finger paralogous to THAP1, which has a crystal structure (PDB: 2KO0) where the protein contacts bases TGGGCA	IPR006612;	57215	THAP domain containing 11 [Source:HGNC Symbol;Acc:HGNC:23194]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	Yes	None	$#ENSP00000304689#ENSG00000168286#ENST00000303596#THAP#CPSF100_C, DDHD, DUF2722	FALSE
1732	ENSG00000137492	THAP12	THAP finger	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR006612;IPR008906;IPR012337;IPR025398	5612	THAP domain containing 12 [Source:HGNC Symbol;Acc:HGNC:9440]	None	Full	Yes	None	None	c	Yes	No	Yes	1a1, Direct HQ evidence	Matt Weirauch	Pratyush Das	Yes	$#ENSG00000137492#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000260045#ENSG00000137492#ENST00000260045#THAP#DUF4371, Dimer_Tnp_hAT	FALSE
1733	ENSG00000173451	THAP2	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;	83591	THAP domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20854]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000310796#ENSG00000173451#ENST00000308086#THAP#$#ENSP00000449826#ENSG00000173451#ENST00000547843#THAP#$#ENSP00000446986#ENSG00000173451#ENST00000551238#THAP#$#ENSP00000448904#ENSG00000173451#ENST00000551488#THAP#	FALSE
1734	ENSG00000041988	THAP3	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;	90326	THAP domain containing 3 [Source:HGNC Symbol;Acc:HGNC:20855]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Tim Hughes	Yes	None	$#ENSP00000054650#ENSG00000041988#ENST00000054650#THAP#$#ENSP00000311537#ENSG00000041988#ENST00000307896#THAP#$#ENSP00000366854#ENSG00000041988#ENST00000377627#THAP#$#ENSP00000473646#ENSG00000041988#ENST00000472925#THAP#	FALSE
1735	ENSG00000176946	THAP4	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;IPR011038;IPR014878;	51078	THAP domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23187]	None	DBD	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Pratyush Das	Yes	None	$#ENSP00000385931#ENSG00000176946#ENST00000402136#THAP#DUF1794$#ENSP00000385006#ENSG00000176946#ENST00000407315#THAP#DUF1794, DUF4201, HrpB7$#ENSP00000482312#ENSG00000176946#ENST00000612200#THAP#DUF1794, DUF4201, HrpB7, IncA$#ENSP00000384352#ENSG00000176946#ENST00000402545#THAP#DUF1794	FALSE
1736	ENSG00000177683	THAP5	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;	168451	THAP domain containing 5 [Source:HGNC Symbol;Acc:HGNC:23188]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000322440#ENSG00000177683#ENST00000313516#THAP#ADIP$#ENSP00000400500#ENSG00000177683#ENST00000415914#THAP#ADIP$#ENSP00000415841#ENSG00000177683#ENST00000438865#THAP#	FALSE
1737	ENSG00000174796	THAP6	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;	152815	THAP domain containing 6 [Source:HGNC Symbol;Acc:HGNC:23189]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	Yes	None	$#ENSP00000309007#ENSG00000174796#ENST00000311638#THAP#DUF4686$#ENSP00000370217#ENSG00000174796#ENST00000380837#THAP#$#ENSP00000426581#ENSG00000174796#ENST00000504190#THAP#$#ENSP00000424255#ENSG00000174796#ENST00000507885#THAP#$#ENSP00000426760#ENSG00000174796#ENST00000508105#THAP#$#ENSP00000423720#ENSG00000174796#ENST00000514480#THAP#DUF4686$#ENSP00000427651#ENSG00000174796#ENST00000507556#THAP#$#ENSP00000426698#ENSG00000174796#ENST00000502620#THAP#$#ENSP00000422402#ENSG00000174796#ENST00000506261#THAP#	FALSE
1738	ENSG00000184436	THAP7	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;	80764	THAP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:23190]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	Yes	None	$#ENSP00000215742#ENSG00000184436#ENST00000215742#THAP#$#ENSP00000382084#ENSG00000184436#ENST00000399133#THAP#	FALSE
1739	ENSG00000161277	THAP8	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None	IPR006612;	199745	THAP domain containing 8 [Source:HGNC Symbol;Acc:HGNC:23191]	None	Full	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	Yes	None	$#ENSP00000292894#ENSG00000161277#ENST00000292894#THAP#	FALSE
1740	ENSG00000168152	THAP9	THAP finger	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Human THAP9 Gene Encodes an Active P-Element DNA Transposase (PMID: 23349291)	IPR006612;	79725	THAP domain containing 9 [Source:HGNC Symbol;Acc:HGNC:23192]	None	not tested	not tested	None	None	c	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000305533#ENSG00000168152#ENST00000302236#THAP#Tnp_P_element	FALSE
1741	ENSG00000275700	AATF	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely does not bind to bind to DNA (PMID: 17634135).	IPR012617;IPR025160	26574	apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:HGNC:19235]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:14627703	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000275700#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000275700##Other#	FALSE
1742	ENSG00000097007	ABL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	25	ABL proto-oncogene 1, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76]	None	not tested	not tested	None	None	No	No	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000097007##Other#	FALSE
1743	ENSG00000174429	ABRA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The Costars domain in this protein is an atypical winged helix protein that does not bind DNA but to other proteins (PMID: 21082705)	IPR027817	137735	actin binding Rho activating protein [Source:HGNC Symbol;Acc:HGNC:30655]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	$#ENSG00000174429#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000311436#ENSG00000174429#ENST00000311955#Other#Costars	FALSE
1744	ENSG00000142396	AC020915.1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	None	endogenous retrovirus group K3 member 1 [Source:HGNC Symbol;Acc:HGNC:30466]	None	not tested	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000489018#ENSG00000142396#ENST00000413518#Other#HERV-K_REC$#ENSP00000488921#ENSG00000142396#ENST00000427361#Other#HERV-K_REC	FALSE
1745	ENSG00000102794	ACOD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR005656	730249	aconitate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:33904]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	$#ENSG00000102794#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000401584#ENSG00000102794#ENST00000449753#Other#MmgE_PrpD$#ENSP00000366682#ENSG00000102794#ENST00000377462#Other#MmgE_PrpD	FALSE
1746	ENSG00000133627	ACTR3B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR004000;IPR020902	57180	ARP3 actin-related protein 3 homolog B (yeast) [Source:HGNC Symbol;Acc:HGNC:17256]	None	not tested	not tested	None	Has no DBDs	No	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Sam Lambert	No	None	$#ENSP00000256001#ENSG00000133627#ENST00000256001#Other#Actin, FtsA, MreB_Mbl$#ENSP00000367007#ENSG00000133627#ENST00000377776#Other#Actin, FtsA, MreB_Mbl$#ENSP00000380452#ENSG00000133627#ENST00000397282#Other#Actin, FtsA, MreB_Mbl	FALSE
1747	ENSG00000106526	ACTR3C	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Pfam match to an APSES domain - this is likely a false positive, as these domains are mostly present in bacteria and fungi	IPR004000;	653857	ARP3 actin-related protein 3 homolog C [Source:HGNC Symbol;Acc:HGNC:37282]	None	not tested	Yes	None	Has no DBDs	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000252071#ENSG00000106526#ENST00000252071#Other#Actin, FtsA$#ENSP00000417426#ENSG00000106526#ENST00000478393#Other#Actin$#ENSP00000418635#ENSG00000106526#ENST00000477871#Other#Actin$#ENSP00000481447#ENSG00000106526#ENST00000613959#Other#	FALSE
1748	ENSG00000151651	ADAM8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000742;IPR001590;IPR001762;IPR002870;IPR006586;IPR013032;IPR018358	101	ADAM metallopeptidase domain 8 [Source:HGNC Symbol;Acc:HGNC:215];Disintegrin and metalloproteinase d	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	$#ENSG00000151651#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000453855#ENSG00000151651#ENST00000415217#Other#ADAM_CR, Disintegrin, EGF_2, Pep_M12B_propep, Repr$#ENSP00000453302#ENSG00000151651#ENST00000445355#Other#ADAM_CR, Disintegrin, EGF_2, Pep_M12B_propep, Repr$#ENSP00000453043#ENSG00000151651#ENST00000485491#Other#ADAM_CR, Disintegrin, Reprolysin, Reprolysin_2, Re$#ENSP00000453735#ENSG00000151651#ENST00000486609#Other#Pep_M12B_propep	FALSE
1749	ENSG00000140470	ADAMTS17	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000884;IPR001590;IPR002870;IPR006586;IPR007087;IPR010294;IPR010909;IPR013273	170691	ADAM metallopeptidase with thrombospondin type 1 motif 17 [Source:HGNC Symbol;Acc:HGNC:17109]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	None	$#ENSP00000268070#ENSG00000140470#ENST00000268070#Other#ADAM_spacer1, PLAC, Pep_M12B_propep, Peptidase_M10$#ENSP00000458005#ENSG00000140470#ENST00000561355#Other#Pep_M12B_propep$#ENSP00000456161#ENSG00000140470#ENST00000568565#Other#ADAM_spacer1	FALSE
1750	ENSG00000145808	ADAMTS19	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR000884;IPR001590;IPR002870;IPR006586;IPR010294;IPR010909;IPR013273;	171019	ADAM metallopeptidase with thrombospondin type 1 motif 19 [Source:HGNC Symbol;Acc:HGNC:17111]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000274487#ENSG00000145808#ENST00000274487#Other#ADAM_spacer1, PLAC, Pep_M12B_propep, Peptidase_M10	FALSE
1751	ENSG00000160710	ADAR	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	PMID: 21728134 shows the ADAR protein bind to ds RNA and Z DNA.  At best it would  be a non-sequence specific DNA binding protein.  But, it has a well established role as a dsRNA binding protein, so it is unlikely to be a TF.	IPR000607;IPR002466;IPR014720;	103	adenosine deaminase, RNA specific [Source:HGNC Symbol;Acc:HGNC:225]	1QBJ	not tested	not tested	None	The structure has the protein bound to double stranded dsDNA	x	No	No	No	3a, decent circumstantial evidence for its role as	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000357456#ENSG00000160710#ENST00000368471#Other#A_deamin, DND1_DSRM, Dicer_dimer, dsrm, z-alpha$#ENSP00000357459#ENSG00000160710#ENST00000368474#Other#A_deamin, DND1_DSRM, TrmB, dsrm, z-alpha$#ENSP00000431794#ENSG00000160710#ENST00000529168#Other#A_deamin, DND1_DSRM, TrmB, dsrm, z-alpha	FALSE
1752	ENSG00000197177	ADGRA1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000832;IPR017981;IPR017983;	84435	adhesion G protein-coupled receptor A1 [Source:HGNC Symbol;Acc:HGNC:13838]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000376383#ENSG00000197177#ENST00000392606#Other#7tm_2$#ENSP00000475778#ENSG00000197177#ENST00000607359#Other#7tm_2$#ENSP00000376384#ENSG00000197177#ENST00000392607#Other#7tm_2	FALSE
1753	ENSG00000182885	ADGRG3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000203;IPR000832;IPR003910;IPR017981	222487	adhesion G protein-coupled receptor G3 [Source:HGNC Symbol;Acc:HGNC:13728]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000182885#GO:0032792#negative regulation of CREB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000332900#ENSG00000182885#ENST00000333493#Other#7tm_2, GPS$#ENSP00000404803#ENSG00000182885#ENST00000450388#Other#7tm_2, GPS	FALSE
1754	ENSG00000106624	AEBP1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).	IPR000421;IPR000834;IPR008969;IPR008979	100616346	AE binding protein 1 [Source:HGNC Symbol;Acc:HGNC:303]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000106624#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:15654748 | IMP - PMID:15654748$#ENSG00000106624#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8920928	$#ENSP00000223357#ENSG00000106624#ENST00000223357#Other#CarbopepD_reg_2, CarboxypepD_reg, F5_F8_type_C, Pe$#ENSP00000398878#ENSG00000106624#ENST00000450684#Other#CarbopepD_reg_2, CarboxypepD_reg, F5_F8_type_C, Pe$#ENSP00000401758#ENSG00000106624#ENST00000449162#Other#$#ENSP00000411277#ENSG00000106624#ENST00000455443#Other#	FALSE
1755	ENSG00000104964	AES	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely a transcriptional co-factor	IPR005617	166	amino-terminal enhancer of split [Source:HGNC Symbol;Acc:HGNC:307]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10660609;11416139	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$##ENSG00000104964##Other#	FALSE
1756	ENSG00000196526	AFAP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	There is no evidence suggesting DNA-binding activity	IPR001849;	60312	actin filament associated protein 1 [Source:HGNC Symbol;Acc:HGNC:24017]	None	DBD	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000353402#ENSG00000196526#ENST00000360265#Other#PH, PH_11, PH_9, Sharpin_PH, Spc7$#ENSP00000351245#ENSG00000196526#ENST00000358461#Other#PH, PH_11, PH_9, Sharpin_PH, Spc7$#ENSP00000410689#ENSG00000196526#ENST00000420658#Other#PH, PH_11, PH_9, Sharpin_PH$#ENSP00000483962#ENSG00000196526#ENST00000614385#Other#	FALSE
1757	ENSG00000172493	AFF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	MLL fusion partner	IPR007797;	4299	AF4/FMR2 family member 1 [Source:HGNC Symbol;Acc:HGNC:7135]	None	Full	not tested	None	None	c	No	No	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Yimeng Yin	No	$#ENSG00000172493#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7689231	$#ENSP00000305689#ENSG00000172493#ENST00000307808#Other#AF-4$#ENSP00000427593#ENSG00000172493#ENST00000507468#Other#AF-4$#ENSP00000378578#ENSG00000172493#ENST00000395146#Other#AF-4$#ENSP00000424483#ENSG00000172493#ENST00000503477#Other#AF-4$#ENSP00000425755#ENSG00000172493#ENST00000511442#Other#AF-4$#ENSP00000424881#ENSG00000172493#ENST00000514970#Other#AF-4	FALSE
1758	ENSG00000144218	AFF3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 8555498) only says that In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose - thats more consistent with nonspecific DNA binding.  The key issue is whether the Transcription factor AF4/FMR2 (IPR007797) domain really is sequence specific.  Most of the work has been done on the one Drosophila ortholog, lilliuputian.  I see no evidence of DNA binding.  Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 261712	IPR007797;	3899	AF4/FMR2 family member 3	None	not tested	not tested	None	None	other	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000396582#ENSG00000144218#ENST00000423966#Other#AF-4$#ENSP00000416685#ENSG00000144218#ENST00000445815#Other#AF-4	FALSE
1759	ENSG00000072364	AFF4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 8555498) only says that In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose - thats more consistent with nonspecific DNA binding.  The key issue is whether the Transcription factor AF4/FMR2 (IPR007797) domain really is sequence specific.  Most of the work has been done on the one Drosophila ortholog, lilliuputian.  I see no evidence of DNA binding.  Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 261712	IPR007797;	27125	AF4/FMR2 family member 4 [Source:HGNC Symbol;Acc:HGNC:17869]	None	not tested	not tested	None	None	c	No	No	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000072364#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10588740	$#ENSP00000265343#ENSG00000072364#ENST00000265343#Other#AF-4, Peptidase_S64$#ENSP00000367858#ENSG00000072364#ENST00000378595#Other#AF-4$#ENSP00000395268#ENSG00000072364#ENST00000421773#Other#AF-4$#ENSP00000409069#ENSG00000072364#ENST00000425658#Other#AF-4	FALSE
1760	ENSG00000204305	AGER	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contacts DNA in the structure (PDB: 4OI7)	IPR003006;IPR003598;IPR003599;IPR007110;IPR013162	None	advanced glycosylation end product-specific receptor [Source:HGNC Symbol;Acc:HGNC:320]	4OI7	not tested	not tested	None	Contacts DNA in the structure (PDB: 4OI7)	No	No	No	Yes	3a, decent circumstantial evidence for its role as a TF or not	Sam Lambert	Pratyush Das	No	None	None	FALSE
1761	ENSG00000135744	AGT	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000227;IPR023795;IPR023796	183	angiotensinogen [Source:HGNC Symbol;Acc:HGNC:333]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000135744#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:17906677	$#ENSP00000355627#ENSG00000135744#ENST00000366667#Other#Serpin	FALSE
1762	ENSG00000163568	AIM2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Based on (PDB: 3RN2), the protein binds DNA but contacts only the backbone; AIM2 binds cytrosolic dsDNA in the innate immune response	IPR004020;IPR004021;IPR011029	9447	absent in melanoma 2 [Source:HGNC Symbol;Acc:HGNC:357];Interferon-inducible protein AIM2	3RN2	not tested	not tested	None	In the structure Non-sequence-specific DNA recognition is accomplished through electrostatic attraction between the positively charged HIN domain residues and the dsDNA sugar-phosphate backbone.. AIM2 binds dsDNA in innate immune response	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Jussi Taipale	Arttu Jolma	No	$#ENSG00000163568#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16432157$#ENSG00000163568#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19158675	$#ENSP00000357112#ENSG00000163568#ENST00000368130#Other#HIN, PYRIN$#ENSP00000357111#ENSG00000163568#ENST00000368129#Other#HIN	FALSE
1763	ENSG00000142208	AKT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR000961;IPR001849;IPR002290;IPR008271;IPR011009;IPR017441;IPR017892	207	AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000142208#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19057511	$#ENSP00000270202#ENSG00000142208#ENST00000349310#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000385326#ENSG00000142208#ENST00000402615#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000384293#ENSG00000142208#ENST00000407796#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000451828#ENSG00000142208#ENST00000554581#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000451166#ENSG00000142208#ENST00000554848#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000450688#ENSG00000142208#ENST00000555528#Other#Kinase-like, PH, PH_11, Pkinase, Pkinase_C, Pkinas$#ENSP00000450681#ENSG00000142208#ENST00000554192#Other#Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000451470#ENSG00000142208#ENST00000555458#Other#Kinase-like, Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000451824#ENSG00000142208#ENST00000555926#Other#PH	FALSE
1764	ENSG00000171094	ALK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates far upstream in the signaling cascade	IPR000719;IPR000998;IPR001245;IPR002011;IPR002172;IPR008266;IPR011009;IPR013320;IPR017441;IPR020635	238	anaplastic lymphoma receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:427]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000171094#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:19459784	$#ENSP00000373700#ENSG00000171094#ENST00000389048#Other#Gly_rich, MAM, Pkinase, Pkinase_Tyr$#ENSP00000414027#ENSG00000171094#ENST00000431873#Other#Pkinase, Pkinase_Tyr$#ENSP00000387488#ENSG00000171094#ENST00000453137#Other#Pkinase_Tyr$#ENSP00000482733#ENSG00000171094#ENST00000618119#Other#Gly_rich, MAM, Pkinase, Pkinase_Tyr	FALSE
1765	ENSG00000189046	ALKBH2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Binds DNA in the crystal structure (PDB: 3BTX)	None	None	alkB homolog 2, alpha-ketoglutarate dependent dioxygenase	3BTX	not tested	not tested	None	Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Binds DNA in the crystal structure (PDB: 3BTX)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1766	ENSG00000104899	AMH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	100423031	Muellerian-inhibiting factor	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000104899#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000104899##Other#	FALSE
1767	ENSG00000176248	ANAPC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Scaffolding protein that associates with ubiquitin ligase complexes	IPR001373;IPR014786;IPR016158;	29882	anaphase promoting complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:19989]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000314004#ENSG00000176248#ENST00000323927#Other#ANAPC2, Cullin	FALSE
1768	ENSG00000148513	ANKRD30A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	GO citation (PMID: 11280766) has no evidence of DNA-binding activity and was based on homology	IPR002110;IPR020683	91074	ankyrin repeat domain 30A [Source:HGNC Symbol;Acc:HGNC:17234]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000148513#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11280766	$#ENSP00000477963#ENSG00000148513#ENST00000611781#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C$#ENSP00000354432#ENSG00000148513#ENST00000361713#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C$#ENSP00000363792#ENSG00000148513#ENST00000374660#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C$#ENSP00000473551#ENSG00000148513#ENST00000602533#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, CCDC144C	FALSE
1769	ENSG00000138772	ANXA3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein operates far upstream on the signaling cascade.	IPR001464;IPR002390;IPR018252;IPR018502	306	annexin A3 [Source:HGNC Symbol;Acc:HGNC:541]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000138772#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16236264	$#ENSP00000264908#ENSG00000138772#ENST00000264908#Other#Annexin$#ENSP00000422281#ENSG00000138772#ENST00000508214#Other#Annexin$#ENSP00000426591#ENSG00000138772#ENST00000512542#Other#Annexin$#ENSP00000421512#ENSG00000138772#ENST00000514171#Other#Annexin	FALSE
1770	ENSG00000196975	ANXA4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001464;IPR002391;IPR002392;IPR018252;IPR018502	307	annexin A4 [Source:HGNC Symbol;Acc:HGNC:542]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000196975#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20237821	$#ENSP00000377833#ENSG00000196975#ENST00000394295#Other#Annexin, Myb_DNA-bind_7$#ENSP00000386756#ENSG00000196975#ENST00000409920#Other#Annexin	FALSE
1771	ENSG00000242802	AP5Z1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	May have helicase activity and play a role in DNA repair (PMID: 20613862)	IPR028222;	9907	adaptor related protein complex 5 zeta 1 subunit [Source:HGNC Symbol;Acc:HGNC:22197]	None	not tested	not tested	None	None	No	No	No	No	1a2, Orthologous HQ evidence	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000297562#ENSG00000242802#ENST00000348624#Other#SPG48	FALSE
1772	ENSG00000113108	APBB3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001202;IPR006020	102465499	amyloid beta precursor protein binding family B member 3 [Source:HGNC Symbol;Acc:HGNC:20708]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Other_PMIDS:10199399;15180993	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000113108##Other#	FALSE
1773	ENSG00000100823	APEX1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	The structure (PDB:1DEW) is with abasic DNA - the protein is a base excision repair enzyme that cleaves off abasic bases	IPR004808;IPR005135;IPR020847;IPR020848	328	apurinic/apyrimidinic endodeoxyribonuclease 1 [Source:HGNC Symbol;Acc:HGNC:587]	1DEW	not tested	not tested	None	The structure is with abasic DNA, the protein is a base excision repair enzyme that cleaves off abasic bases	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:1380454;15084519;15674341	No	3a, decent circumstantial evidence for its role as	Tim Hughes	Arttu Jolma	No	None	$##ENSG00000100823##Other#	FALSE
1774	ENSG00000262156	APOBEC3A	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds ssDNA (PDB: 5KEG)	None	None	apolipoprotein B mRNA editing enzyme catalytic subunit 3A	5KEG	not tested	not tested	None	Binds ssDNA (PDB: 5KEG)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1775	ENSG00000179750	APOBEC3B	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds ssDNA (PDB: 5TD5)	None	None	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	5TD5	not tested	not tested	None	Binds ssDNA (PDB: 5TD5)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1776	ENSG00000239713	APOBEC3G	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Restriction factor of HIV-1 that binds ssDNA (PDB: 5K83)	None	None	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	5K83	not tested	not tested	None	Restriction factor of HIV-1 that binds ssDNA (PDB: 5K83)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1777	ENSG00000137074	APTX	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds and fixes DNA-RNA hybrids/ APTX efficiently repairs adenylated RNA-DNA and acts in the RNA-DNA damage response (PMID: 24362567)	IPR000253;IPR007087;IPR008984;IPR011146;IPR019808;	54840	aprataxin [Source:HGNC Symbol;Acc:HGNC:15984]	4NDF	Full	not tested	None	Binds and fixes DNA-RNA hybrids APTX efficiently repairs adenylated RNA-DNA, and acting in an RNA-DNA damage response (RDDR) pmid: 24362567	x	No	No	No	3a, decent circumstantial evidence for its role as	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000311547#ENSG00000137074#ENST00000309615#Other#DcpS_C, HIT, zf-C2HE$#ENSP00000369145#ENSG00000137074#ENST00000379817#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000369147#ENSG00000137074#ENST00000379819#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000380357#ENSG00000137074#ENST00000397172#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000400806#ENSG00000137074#ENST00000436040#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000419846#ENSG00000137074#ENST00000463596#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000420263#ENSG00000137074#ENST00000468275#Other#DcpS_C, FHA, HIT, zf-C2HE$#ENSP00000419042#ENSG00000137074#ENST00000476858#Other#DcpS_C, HIT, zf-C2HE$#ENSP00000369153#ENSG00000137074#ENST00000379825#Other#DcpS_C, FHA, HIT$#ENSP00000419020#ENSG00000137074#ENST00000473221#Other#DcpS_C, HIT$#ENSP00000417649#ENSG00000137074#ENST00000477119#Other#DcpS_C, HIT	FALSE
1778	ENSG00000160007	ARHGAP35	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds DNA specifically based on EMSA and nuclease protection assay data (PMID: 1894621), despite lacking any clear DBDs.	IPR000198;IPR001806;IPR002713;IPR008936;IPR027417;	2909	Rho GTPase activating protein 35 [Source:HGNC Symbol;Acc:HGNC:4591]	None	not tested	not tested	None	None	other	No	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1894621	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000160007#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:1894621	$#ENSP00000385720#ENSG00000160007#ENST00000404338#Other#FF, Ras, RhoGAP, RhoGAP-FF1$#ENSP00000483730#ENSG00000160007#ENST00000614079#Other#FF, Ras, RhoGAP, RhoGAP-FF1$#ENSP00000479487#ENSG00000160007#ENST00000615647#Other#FF, Ras, RhoGAP-FF1	FALSE
1779	ENSG00000116584	ARHGEF2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000219;IPR001849;IPR002219	9181	Rho/Rac guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:682]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000116584#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19043560, PMID:21887730	$#ENSP00000314787#ENSG00000116584#ENST00000313667#Other#C1_1, C1_2, PH, Prok-RING_1, RhoGEF$#ENSP00000315325#ENSG00000116584#ENST00000313695#Other#C1_1, C1_2, PH, Prok-RING_1, RhoGEF$#ENSP00000354837#ENSG00000116584#ENST00000361247#Other#C1_1, C1_2, PH, Prok-RING_1, RhoGEF$#ENSP00000476699#ENSG00000116584#ENST00000609707#Other#C1_1, C1_2, Prok-RING_1, zinc_ribbon_9$#ENSP00000476518#ENSG00000116584#ENST00000423422#Other#$#ENSP00000476689#ENSG00000116584#ENST00000470541#Other#$#ENSP00000476724#ENSG00000116584#ENST00000497907#Other#C1_1, C1_2, Prok-RING_1, zinc_ribbon_9	FALSE
1780	ENSG00000050327	ARHGEF5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GO annotation provides no evidence of DNA-binding activity (PMID: 15601624)	IPR000219;IPR001331;IPR001452;IPR001849;IPR029212	102725117	Rho guanine nucleotide exchange factor 5 [Source:HGNC Symbol;Acc:HGNC:13209]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000050327#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15601624	$#ENSP00000056217#ENSG00000050327#ENST00000056217#Other#ARHGEF5_35, PH, RhoGEF, SH3_1, SH3_2, SH3_9$#ENSP00000418227#ENSG00000050327#ENST00000471847#Other#PH, RhoGEF, SH3_1, SH3_2, SH3_9$#ENSP00000417979#ENSG00000050327#ENST00000498580#Other#ARHGEF5_35$#ENSP00000418745#ENSG00000050327#ENST00000474817#Other#RhoGEF, SH3_1, SH3_2, SH3_9	FALSE
1781	ENSG00000137486	ARRB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ChIP data available, but unclear if it can bind to DNA directly (PMID: 16325578)	IPR000698;IPR011021;IPR011022;IPR014756;IPR017864	408	arrestin beta 1 [Source:HGNC Symbol;Acc:HGNC:711]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000137486#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16378096	$#ENSP00000353124#ENSG00000137486#ENST00000360025#Other#Arrestin_C, Arrestin_N$#ENSP00000409581#ENSG00000137486#ENST00000420843#Other#Arrestin_C, Arrestin_N$#ENSP00000436530#ENSG00000137486#ENST00000532447#Other#Arrestin_C, Arrestin_N$#ENSP00000433171#ENSG00000137486#ENST00000532525#Other#Arrestin_C, Arrestin_N	FALSE
1782	ENSG00000141480	ARRB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000698;IPR011021;IPR011022;IPR014756;IPR017864	409	arrestin beta 2 [Source:HGNC Symbol;Acc:HGNC:712]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000141480#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15125834, PMID:16378096	$#ENSP00000269260#ENSG00000141480#ENST00000269260#Other#Arrestin_C, Arrestin_N$#ENSP00000466344#ENSG00000141480#ENST00000574954#Other#Arrestin_C$#ENSP00000341895#ENSG00000141480#ENST00000346341#Other#Arrestin_C, Arrestin_N$#ENSP00000370898#ENSG00000141480#ENST00000381488#Other#Arrestin_C, Arrestin_N$#ENSP00000403701#ENSG00000141480#ENST00000412477#Other#Arrestin_C, Arrestin_N$#ENSP00000465877#ENSG00000141480#ENST00000571428#Other#Arrestin_C	FALSE
1783	ENSG00000138303	ASCC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a coactivator that is reported to bind to SRF, NFKB1, and JUN (PMID: 12077347)	IPR004087;IPR004088;IPR009097;IPR009210;IPR019510	51008	activating signal cointegrator 1 complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24268]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10454579	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$##ENSG00000138303##Other#	FALSE
1784	ENSG00000171681	ATF7IP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Murine homolog involved in H4K9 trimethylation by SETDB1 (PMID: 14536086)	IPR003961	55729	activating transcription factor 7 interacting protein [Source:HGNC Symbol;Acc:HGNC:20092]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10777215;14536086	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$##ENSG00000171681##Other#	FALSE
1785	ENSG00000149311	ATM	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase protein that binds to and activates certain TFs	IPR000403;IPR003151;IPR003152;IPR011009;IPR014009;IPR016024;IPR018936;IPR021668	472	ataxia telangiectasia mutated homolog, ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:12496286;16461339;16644862	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$##ENSG00000149311##Other#	FALSE
1786	ENSG00000175054	ATR	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR000403;IPR003151;IPR003152;IPR011009;IPR012993;IPR014009;IPR016024;IPR018936;IPR021133	545	ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding; Single stranded RNA/DNA binding_Other_PMIDS:10545197;12011	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000175054##Other#	FALSE
1787	ENSG00000085224	ATRX	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	ATRX does not contain any canonical sequence-specific DBDs but it does contain a non-specific DNA binding helicase that allows it to bind repeat sequences (PMID:21029860) and telomeres (PMID:20651253). ATRX is involved in multiple processes (transcription, replication), and is associated with multiple complexes (Swi/Snf, histone chaperones, and repressive complexes including TRIM 28 (PMID:27029610)), and as such does affect transcription. Given the lack of sequence-specific binding it is unlikel	None	None	None	None	not tested	not tested	None	None	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1788	ENSG00000163635	ATXN7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ATXN7 SCA7 domain facilitates interactions with histone dimers (PMID: 20634802)	IPR013243;	6314	ataxin 7 [Source:HGNC Symbol;Acc:HGNC:10560]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000295900#ENSG00000163635#ENST00000295900#Other#SCA7$#ENSP00000418203#ENSG00000163635#ENST00000474513#Other#$#ENSP00000428277#ENSG00000163635#ENST00000484332#Other#SCA7$#ENSP00000439585#ENSG00000163635#ENST00000538065#Other#SCA7$#ENSP00000428067#ENSG00000163635#ENST00000522345#Other#	FALSE
1789	ENSG00000107262	BAG1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Antiapoptotic BCL-protein	IPR000626;IPR003103;IPR017093;IPR029071	573	Bcl2-associated athanogene 1	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9642262	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$##ENSG00000107262##Other#	FALSE
1790	ENSG00000175334	BANF1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure, contacting only the backbone from the side of the minor groove (PDB: 2BZF)	None	None	barrier to autointegration factor 1	2BZF	not tested	not tested	None	Binds DNA in the crystal structure, contacting only the backbone from the side of the minor groove (PDB: 2BZF)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1791	ENSG00000172530	BANP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	BANP has no DBD and is known to bind other TFs; likely that the Transfac motif is from one of its binding partners	IPR018379	54971	BTG3 associated nuclear protein [Source:HGNC Symbol;Acc:HGNC:13450]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000347125#ENSG00000172530#ENST00000355022#Other#BEN, DUF1845$#ENSP00000432508#ENSG00000172530#ENST00000479780#Other#BEN, DUF1845$#ENSP00000444352#ENSG00000172530#ENST00000538234#Other#BEN, DUF1845$#ENSP00000376902#ENSG00000172530#ENST00000393207#Other#BEN$#ENSP00000376903#ENSG00000172530#ENST00000393208#Other#BEN, DUF1845$#ENSP00000487304#ENSG00000172530#ENST00000626016#Other#BEN, DUF1845$#ENSP00000401454#ENSG00000172530#ENST00000436274#Other#	FALSE
1792	ENSG00000142867	BCL10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Apoptosis associated protein that operates upstream on a cascade that includes NFKB	IPR001315;IPR011029	8915	B-cell CLL/lymphoma 10 [Source:HGNC Symbol;Acc:HGNC:989]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000142867#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10400625, PMID:14695475	$#ENSP00000359612#ENSG00000142867#ENST00000370580#Other#CARD$#ENSP00000480561#ENSG00000142867#ENST00000620248#Other#CARD, CARD_2	FALSE
1793	ENSG00000069399	BCL3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	No DBD - instead, this is a known cofactor of NF-kappaB.  The Transfac motif is the NFKB1 motif.  GO cites only electronic annotation and needs to be fixed.	IPR002110;IPR020683	102465879	B-cell CLL/lymphoma 3 [Source:HGNC Symbol;Acc:HGNC:998]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:1501714	No	2a1, Lower confidence direct evidence	Arttu Jolma	Tim Hughes	Yes	$#ENSG00000069399#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000164227#ENSG00000069399#ENST00000164227#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000393731#ENSG00000069399#ENST00000444487#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5	FALSE
1794	ENSG00000029363	BCLAF1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	No DBD. Only weak evidence is available for indirect binding (PMID: 10330179). Suspect motif - it is a clear ETS-site. (PMID: 10330179) shows that the protein binds DNA in filter binding assay, but not that it is sequence specific.	IPR018545;IPR029199	9774	BCL2 associated transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:16863]	None	not tested	not tested	None	None	other	Yes	No	No	2a1, Lower confidence direct evidence	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000434826#ENSG00000029363#ENST00000527759#Other#THRAP3_BCLAF1$#ENSP00000436501#ENSG00000029363#ENST00000530767#Other#THRAP3_BCLAF1$#ENSP00000435210#ENSG00000029363#ENST00000531224#Other#THRAP3_BCLAF1$#ENSP00000437018#ENSG00000029363#ENST00000534762#Other#Btz	FALSE
1795	ENSG00000183337	BCOR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-repressor that associates with BCL6 (PMID: 10898795)	IPR002110;IPR020683	54880	BCL6 corepressor [Source:HGNC Symbol;Acc:HGNC:20893]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10898795;10898795	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$##ENSG00000183337##Other#	FALSE
1796	ENSG00000145734	BDP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001005;IPR009057	55814	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB [Source:HGNC Sy	None	Full	not tested	None	None	x	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11971960;12930823;14527415;15469824	No	4a, two or more datasets predict it as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000351575#ENSG00000145734#ENST00000358731#Other#Myb_DNA-bind_7$#ENSP00000370050#ENSG00000145734#ENST00000380675#Other#Myb_DNA-bind_7	FALSE
1797	ENSG00000133169	BEX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely a cofactor- (PMID: 16314316) shows results for related BEX2	IPR007623;IPR021156	55859	brain expressed X-linked 1 [Source:HGNC Symbol;Acc:HGNC:1036]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000133169#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16314316	$#ENSP00000361813#ENSG00000133169#ENST00000372728#Other#BEX	FALSE
1798	ENSG00000136717	BIN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001452;IPR003005;IPR003023;IPR004148	274	bridging integrator 1 [Source:HGNC Symbol;Acc:HGNC:1052]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__Co-activation_PMIDS:15992821	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Jussi Taipale	No	None	$##ENSG00000136717##Other#	FALSE
1799	ENSG00000197299	BLM	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Helicase involved in DNA replication and repair (PDB: 4CGZ)	None	None	Bloom syndrome RecQ like helicase	4CGZ	not tested	not tested	None	Helicase involved in DNA replication and repair (PDB: 4CGZ)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1800	ENSG00000117475	BLZF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is a golgi protein with no evidence for DNA binding.	IPR013183	8548	basic leucine zipper nuclear factor 1 [Source:HGNC Symbol;Acc:HGNC:1065]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:9129147;10602419	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000117475#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9129147	$#ENSP00000327541#ENSG00000117475#ENST00000329281#Other#DASH_Hsk3$#ENSP00000356781#ENSG00000117475#ENST00000367807#Other#$#ENSP00000356782#ENSG00000117475#ENST00000367808#Other#DASH_Hsk3$#ENSP00000414668#ENSG00000117475#ENST00000420531#Other#$#ENSP00000404408#ENSG00000117475#ENST00000426663#Other#DASH_Hsk3	FALSE
1801	ENSG00000168283	BMI1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	BMI1 binds to nucleosomes as part of the PRC1 complex but does not contact the DNA directly (PDB: 4R8P)	IPR001841;IPR017907;IPR018957;	648	BMI1 proto-oncogene, polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066]	4R8P	DBD	not tested	None	Does not contact DNA in the structure, but contacts core-nucleosomes and RNF2	b	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:1823128;10500182;15386022	No	3a, decent circumstantial evidence for its role as	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000365851#ENSG00000168283#ENST00000376663#Other#Prok-RING_4, RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000390768#ENSG00000168283#ENST00000443519#Other#Prok-RING_4, RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000399220#ENSG00000168283#ENST00000416820#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-$#ENSP00000397912#ENSG00000168283#ENST00000442508#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-	FALSE
1802	ENSG00000125845	BMP2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001111;IPR001839;IPR002405;IPR017948;IPR029034;	650	bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069]	None	not tested	not tested	None	None	other	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000368104#ENSG00000125845#ENST00000378827#Other#TGF_beta, TGFb_propeptide	FALSE
1803	ENSG00000125378	BMP4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely a cofactor.	IPR001111;IPR001839;IPR017948;IPR029034	652	bone morphogenetic protein 4 [Source:HGNC Symbol;Acc:HGNC:1071]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:12538588	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	None	$##ENSG00000125378##Other#	FALSE
1804	ENSG00000101144	BMP7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001111;IPR001839;IPR002405;IPR017948;IPR029034	655	bone morphogenetic protein 7 [Source:HGNC Symbol;Acc:HGNC:1074]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:9369451	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000101144#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000379204#ENSG00000101144#ENST00000395863#Other#TGF_beta, TGFb_propeptide$#ENSP00000398687#ENSG00000101144#ENST00000450594#Other#TGF_beta, TGFb_propeptide$#ENSP00000379205#ENSG00000101144#ENST00000395864#Other#TGF_beta, TGFb_propeptide$#ENSP00000390814#ENSG00000101144#ENST00000433911#Other#TGF_beta, TGFb_propeptide	FALSE
1805	ENSG00000107779	BMPR1A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	657	Bone morphogenetic protein receptor type-1A	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000107779#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000107779##Other#	FALSE
1806	ENSG00000038219	BOD1L1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR026955;	259282	biorientation of chromosomes in cell division 1 like 1 [Source:HGNC Symbol;Acc:HGNC:31792]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$#ENSP00000040738#ENSG00000038219#ENST00000040738#Other#COMPASS-Shg1$#ENSP00000425492#ENSG00000038219#ENST00000507943#Other#	FALSE
1807	ENSG00000178096	BOLA1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002634;	51027	bolA family member 1 [Source:HGNC Symbol;Acc:HGNC:24263]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000358148#ENSG00000178096#ENST00000369152#Other#BolA$#ENSP00000358146#ENSG00000178096#ENST00000369150#Other#BolA$#ENSP00000358149#ENSG00000178096#ENST00000369153#Other#BolA	FALSE
1808	ENSG00000183336	BOLA2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002634;	107984053	BolA family member 2 [Source:HGNC Symbol;Acc:HGNC:29488]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000331127#ENSG00000183336#ENST00000330978#Other#BolA	FALSE
1809	ENSG00000169627	BOLA2B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002634;	107984053	BolA family member 2B [Source:HGNC Symbol;Acc:HGNC:32479]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000306752#ENSG00000169627#ENST00000305321#Other#BolA$#ENSP00000457995#ENSG00000169627#ENST00000567436#Other#BolA$#ENSP00000455468#ENSG00000169627#ENST00000569282#Other#	FALSE
1810	ENSG00000163170	BOLA3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	E. Coli homologue of the BOLA binds DNA; however there is no evidence in the mammalian proteins	IPR002634;	388962	bolA family member 3 [Source:HGNC Symbol;Acc:HGNC:24415]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000295326#ENSG00000163170#ENST00000295326#Other#$#ENSP00000331369#ENSG00000163170#ENST00000327428#Other#BolA	FALSE
1811	ENSG00000162813	BPNT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000760;IPR020550;IPR020583;	10380	3(2), 5-bisphosphate nucleotidase 1 [Source:HGNC Symbol;Acc:HGNC:1096]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000318852#ENSG00000162813#ENST00000322067#Other#Inositol_P$#ENSP00000410348#ENSG00000162813#ENST00000414869#Other#Inositol_P$#ENSP00000444398#ENSG00000162813#ENST00000544404#Other#Inositol_P$#ENSP00000446953#ENSG00000162813#ENST00000463953#Other#Inositol_P$#ENSP00000449883#ENSG00000162813#ENST00000498237#Other#Inositol_P$#ENSP00000446850#ENSG00000162813#ENST00000498791#Other#Inositol_P	FALSE
1812	ENSG00000171634	BPTF	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook	(PMID: 10575013) obtained a motif by SELEX and showed that mutating the sequence diminished binding in vitro.   Unusual for a PHD/Ring finger, but its there in the literature.	IPR001487;IPR001965;IPR004022;IPR011011;IPR018359;IPR018500;IPR018501;IPR019786;IPR019787;IPR028942	2186	bromodomain PHD finger transcription factor [Source:HGNC Symbol;Acc:HGNC:3581]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:10575013;10727212	No	2a1, Lower confidence direct evidence	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000307208#ENSG00000171634#ENST00000306378#Other#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000343837#ENSG00000171634#ENST00000342579#Other#Bromodomain, PHD$#ENSP00000388405#ENSG00000171634#ENST00000424123#Other#Bromodomain, DDT, PHD, WHIM1, WSD$#ENSP00000462535#ENSG00000171634#ENST00000580465#Other#$#ENSP00000463845#ENSG00000171634#ENST00000581258#Other#Bromodomain, DUF4428, PHD$#ENSP00000463736#ENSG00000171634#ENST00000583990#Other#Bromodomain$#ENSP00000443949#ENSG00000171634#ENST00000544491#Other#$#ENSP00000462703#ENSG00000171634#ENST00000577837#Other#Bromodomain	FALSE
1813	ENSG00000012048	BRCA1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	In vivo/Misc source	None	BRCA1 likely binds to DNA without DNA sequence specificity (PMID: 11353843)	IPR001357;IPR001841;IPR011364;IPR017907;IPR018957;IPR025994	672	BRCA1, DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100]	None	not tested	not tested	None	Jaspar SELEX model has very small information content, looking like an selection artefact	b	Yes	No	No	2a1, Lower confidence direct evidence	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000326002#ENSG00000012048#ENST00000354071#Other#BRCT_assoc, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-$#ENSP00000350283#ENSG00000012048#ENST00000357654#Other#BRCT, BRCT_2, BRCT_assoc, Prok-RING_4, zf-ANAPC11,$#ENSP00000417148#ENSG00000012048#ENST00000468300#Other#BRCT, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_$#ENSP00000419274#ENSG00000012048#ENST00000470026#Other#BRCT_assoc, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-$#ENSP00000418960#ENSG00000012048#ENST00000471181#Other#BRCT, BRCT_2, BRCT_assoc, Prok-RING_4, zf-ANAPC11,$#ENSP00000419988#ENSG00000012048#ENST00000477152#Other#BRCT_assoc, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-N$#ENSP00000420412#ENSG00000012048#ENST00000478531#Other#BRCT, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_$#ENSP00000419103#ENSG00000012048#ENST00000494123#Other#BRCT_assoc, Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-$#ENSP00000418986#ENSG00000012048#ENST00000497488#Other#BRCT_assoc$#ENSP00000465818#ENSG00000012048#ENST00000586385#Other#BRCT, BRCT_2$#ENSP00000467329#ENSG00000012048#ENST00000591534#Other#BRCT, BRCT_2$#ENSP00000465347#ENSG00000012048#ENST00000591849#Other#BRCT$#ENSP00000478114#ENSG00000012048#ENST00000618469#Other#$#ENSP00000417241#ENSG00000012048#ENST00000461574#Other#$#ENSP00000420201#ENSG00000012048#ENST00000473961#Other#BRCT_assoc$#ENSP00000418819#ENSG00000012048#ENST00000493919#Other#BRCT	FALSE
1814	ENSG00000141867	BRD4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Binds acetylated histones	IPR001487;IPR018359;IPR027353	23476	bromodomain containing 4 [Source:HGNC Symbol;Acc:HGNC:13575]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:16109376	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000141867##Other#	FALSE
1815	ENSG00000166164	BRD7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001487;IPR021900	29117	bromodomain containing 7 [Source:HGNC Symbol;Acc:HGNC:14310]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation_PMIDS:12489984	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$##ENSG00000166164##Other#	FALSE
1816	ENSG00000112983	BRD8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	TF-coactivator	IPR001487	10902	bromodomain containing 8 [Source:HGNC Symbol;Acc:HGNC:19874]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000112983#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8611617$#ENSG00000112983#GO:0004887#thyroid hormone receptor activity#TAS - PMID:9368056	$#ENSP00000230901#ENSG00000112983#ENST00000230901#Other#Bromodomain$#ENSP00000254900#ENSG00000112983#ENST00000254900#Other#Bromodomain$#ENSP00000392646#ENSG00000112983#ENST00000427976#Other#Bromodomain	FALSE
1817	ENSG00000028310	BRD9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Evidence ony for interaction with histones (PMID: 22464331)	IPR001487;IPR021900	65980	bromodomain containing 9 [Source:HGNC Symbol;Acc:HGNC:25818]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000419765#ENSG00000028310#ENST00000467963#Other#Bromodomain, DUF3512$#ENSP00000419845#ENSG00000028310#ENST00000483173#Other#Bromodomain, DUF3512$#ENSP00000420722#ENSG00000028310#ENST00000489093#Other#Bromodomain, DUF3512	FALSE
1818	ENSG00000185024	BRF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	GTF - Pol III - TRANSFAC has a motif but its likely not for this protein, but for the complex as a whole	IPR000812;IPR011665;IPR013137;IPR013150;IPR013763	2972	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit [Source:HGNC Symbol;Acc:HGNC	1NGM	not tested	not tested	None	In the structure the BRFIII does not contact DNA, (structure is for the yeast homolog)	No	Yes	TF Gene_Basal Transcription Factor_Other_PMIDS:8943358;12198173;14976220;15538381	No	2a1, Lower confidence direct evidence	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000369269#ENSG00000185024#ENST00000379937#Other#BRF1, Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000376340#ENSG00000185024#ENST00000392557#Other#BRF1, TFIIB$#ENSP00000448387#ENSG00000185024#ENST00000547530#Other#BRF1, Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000446707#ENSG00000185024#ENST00000548421#Other#Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000446901#ENSG00000185024#ENST00000551787#Other#TFIIB$#ENSP00000329029#ENSG00000185024#ENST00000327359#Other#BRF1, Cyclin_N, TFIIB$#ENSP00000388877#ENSG00000185024#ENST00000440513#Other#BRF1, Cyclin_N, TFIIB$#ENSP00000389859#ENSG00000185024#ENST00000446501#Other#BRF1$#ENSP00000448723#ENSG00000185024#ENST00000549655#Other#TFIIB$#ENSP00000450258#ENSG00000185024#ENST00000546417#Other#TFIIB$#ENSP00000449173#ENSG00000185024#ENST00000550208#Other#TFIIB$#ENSP00000447521#ENSG00000185024#ENST00000550375#Other#	FALSE
1819	ENSG00000104221	BRF2	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Makes backbone and sequence-specific interactions with DNA (PDB: 4ROC), but only involved in recognizing dinucleotides flanking the TATA box (PMID: 26638071). Redox sensing determines activation and repression of target genes	None	None	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	4ROC	not tested	not tested	None	Makes backbone and sequence-specific interactions with DNA (PDB: 4ROC), but only involved in recognizing dinucleotides flanking the TATA box (PMID: 26638071). Redox sensing determines activation and repression of target genes	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1820	ENSG00000174744	BRMS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	BRMS1 functions as a corepressor by promoting binding of HDAC1 to RelA/p65, where it deacetylates lysine K310 on RelA/p65, which suppresses RelA/p65 transcriptional activity (PMID: 17000776)	IPR013907	25855	breast cancer metastasis suppressor 1 [Source:HGNC Symbol;Acc:HGNC:17262]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000174744#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:17000776	$#ENSP00000353042#ENSG00000174744#ENST00000359957#Other#Sds3$#ENSP00000433740#ENSG00000174744#ENST00000530756#Other#Sds3$#ENSP00000431510#ENSG00000174744#ENST00000524699#Other#Sds3$#ENSP00000396052#ENSG00000174744#ENST00000425825#Other#Sds3	FALSE
1821	ENSG00000156983	BRPF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR000313;IPR001487;IPR001965;IPR007087;IPR011011;IPR018359;IPR019542;IPR019786;IPR019787;	7862	bromodomain and PHD finger containing 1 [Source:HGNC Symbol;Acc:HGNC:14255]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000373340#ENSG00000156983#ENST00000383829#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000398863#ENSG00000156983#ENST00000424362#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000402485#ENSG00000156983#ENST00000433861#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000410210#ENSG00000156983#ENST00000457855#Other#Bromodomain, EPL1, PHD, PHD_2, PWWP, zf-HC5HC2H, z$#ENSP00000416728#ENSG00000156983#ENST00000420291#Other#	FALSE
1822	ENSG00000095564	BTAF1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Protein that uses ATP to dissociate TBP from the promoter	IPR000330;IPR001650;IPR014001;IPR016024;IPR022707;IPR027417	9044	B-TFIID TATA-box binding protein associated factor 1 [Source:HGNC Symbol;Acc:HGNC:17307]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11585931	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000095564#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9342322	$#ENSP00000265990#ENSG00000095564#ENST00000265990#Other#DUF3535, HEAT, HEAT_2, HEAT_EZ, Helicase_C, SNF2_N$#ENSP00000439924#ENSG00000095564#ENST00000544642#Other#DUF3535, HEAT, HEAT_2, HEAT_EZ, Helicase_C, SNF2_N	FALSE
1823	ENSG00000189195	BTBD8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Probably annotated as TF based on presence of a BTB domain; however, these domains are not known to bind DNA	IPR000210;IPR011333;IPR013069	284697	BTB domain containing 8 [Source:HGNC Symbol;Acc:HGNC:21019];BTB/POZ domain-containing protein 8	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000189195#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000343686#ENSG00000189195#ENST00000342818#Other#BACK, BTB$#ENSP00000359404#ENSG00000189195#ENST00000370378#Other#BACK, DUF4596$#ENSP00000490161#ENSG00000189195#ENST00000636805#Other#BACK, BTB, DUF4596$#ENSP00000490913#ENSG00000189195#ENST00000637221#Other#DUF4596	FALSE
1824	ENSG00000159388	BTG2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-factor (PMID: 10617598)	IPR002087;	7832	BTG family member 2 [Source:HGNC Symbol;Acc:HGNC:1131]	None	not tested	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000159388#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000290551#ENSG00000159388#ENST00000290551#Other#BTG	FALSE
1825	ENSG00000010671	BTK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Involved in the regulation of ARID3A and NFAT in B lymphocyte development; has been thoroughly investigated, but there is no evidence to demonstrate DNA binding activity (see UniProt Q06187)	IPR000719;IPR000980;IPR001245;IPR001452;IPR001562;IPR001849;IPR008266;IPR011009;IPR017441;IPR020635	695	Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000010671#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:19290921	$#ENSP00000308176#ENSG00000010671#ENST00000308731#Other#BTK, Kinase-like, PH, Pkinase, Pkinase_Tyr, SH2, S$#ENSP00000483570#ENSG00000010671#ENST00000621635#Other#BTK, Kinase-like, PH, Pkinase, Pkinase_Tyr, SH2, S$#ENSP00000361971#ENSG00000010671#ENST00000372880#Other#BTK, PH, Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, $#ENSP00000479125#ENSG00000010671#ENST00000618050#Other#BTK, PH, Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2,	FALSE
1826	ENSG00000166167	BTRC	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001680;IPR001810;IPR017986;IPR019775;IPR020472;IPR021977	8945	beta-transducin repeat containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:1144]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000166167#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:11001584	$#ENSP00000359206#ENSG00000166167#ENST00000370187#Other#ANAPC4_WD40, Beta-TrCP_D, F-box, F-box-like, Nup16$#ENSP00000377088#ENSG00000166167#ENST00000393441#Other#ANAPC4_WD40, Beta-TrCP_D, F-box, F-box-like, Nup16$#ENSP00000385339#ENSG00000166167#ENST00000408038#Other#ANAPC4_WD40, Beta-TrCP_D, F-box, F-box-like, Nup16$#ENSP00000359202#ENSG00000166167#ENST00000370183#Other#Beta-TrCP_D	FALSE
1827	ENSG00000106245	BUD31	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included because GO says its DNA binding on the basis of (PMID: 7841202), a 1995 paper that only suggests DNA binding on the basis of the protein sequence.  In fact, it is composed entirely of a G10 domain.	IPR001748;IPR018230	8896	BUD31 homolog [Source:HGNC Symbol;Acc:HGNC:29629]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Jussi Taipale	No	$#ENSG00000106245#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7841202$#ENSG00000106245#GO:2000825#positive regulation of androgen receptor activity#IDA - PMID:25091737	$#ENSP00000222969#ENSG00000106245#ENST00000222969#Other#G10$#ENSP00000386023#ENSG00000106245#ENST00000403633#Other#G10$#ENSP00000408269#ENSG00000106245#ENST00000431419#Other#G10$#ENSP00000395269#ENSG00000106245#ENST00000456893#Other#G10	FALSE
1828	ENSG00000179008	C14orf39	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR031380	317761	chromosome 14 open reading frame 39 [Source:HGNC Symbol;Acc:HGNC:19849]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000179008#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#NAS - PMID:15703187	$#ENSP00000324920#ENSG00000179008#ENST00000321731#Other#S6OS1$#ENSP00000451441#ENSG00000179008#ENST00000556799#Other#DUF1664, S6OS1, polyprenyl_synt$#ENSP00000451665#ENSG00000179008#ENST00000555476#Other#S6OS1	FALSE
1829	ENSG00000197223	C1D	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	C1D has been shown to bind RNA (PMID: 17412707) and is associated with the exosome. C1D is also associated with DNA repair and has DNA-binding activitiy (PMID: 10362552)	IPR007146	10438	C1D nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29911]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9405624	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000197223##Other#	FALSE
1830	ENSG00000088854	C20orf194	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	25943	chromosome 20 open reading frame 194 [Source:HGNC Symbol;Acc:HGNC:17721]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000252032#ENSG00000088854#ENST00000252032#Other#SIR2_2	FALSE
1831	ENSG00000174928	C3orf33	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Some effect on DNA-binding of AP-1 (PMID: 20680465), but does no data supporting a role for C3orf33 as a DNA-binding factor itself	IPR016071	285315	chromosome 3 open reading frame 33 [Source:HGNC Symbol;Acc:HGNC:26434]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000174928#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20680465	$#ENSP00000342512#ENSG00000174928#ENST00000340171#Other#$#ENSP00000445446#ENSG00000174928#ENST00000534941#Other#	FALSE
1832	ENSG00000105298	CACTIN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein operates on a signaling cascade far upstream of NFKB (PMID: 20829348)	IPR018816;IPR019134	58509	cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000105298#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20829348	$#ENSP00000221899#ENSG00000105298#ENST00000221899#Other#CactinC_cactus, Cactin_mid$#ENSP00000467149#ENSG00000105298#ENST00000592721#Other#CactinC_cactus$#ENSP00000415078#ENSG00000105298#ENST00000429344#Other#CactinC_cactus, Cactin_mid$#ENSP00000467788#ENSG00000105298#ENST00000588749#Other#Cactin_mid	FALSE
1833	ENSG00000183049	CAMK1D	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Functions in signalling cascade that leads to phosphorylation and activation of CREB (PMID: 16324104)	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	57118	calcium/calmodulin dependent protein kinase ID [Source:HGNC Symbol;Acc:HGNC:19341]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	$#ENSG00000183049#GO:0032793#positive regulation of CREB transcription factor activity#IDA - PMID:16324104	$#ENSP00000368122#ENSG00000183049#ENST00000378845#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000478874#ENSG00000183049#ENST00000619168#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000478861#ENSG00000183049#ENST00000615792#Other#Kdo, Kinase-like, Pkinase, Pkinase_Tyr	FALSE
1834	ENSG00000070808	CAMK2A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR008271;IPR011009;IPR013543;IPR017441	815	calcium/calmodulin dependent protein kinase II alpha [Source:HGNC Symbol;Acc:HGNC:1460]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000070808#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:17052756	$#ENSP00000261793#ENSG00000070808#ENST00000348628#Other#APH, CaMKII_AD, DUF4440, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000381412#ENSG00000070808#ENST00000398376#Other#APH, CaMKII_AD, DUF4440, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000426607#ENSG00000070808#ENST00000510347#Other#Pkinase, Pkinase_Tyr$#ENSP00000427580#ENSG00000070808#ENST00000515758#Other#Pkinase	FALSE
1835	ENSG00000103326	CAPN15	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Basically an unknown protein - a likely protease that contains also znfRANBP-domains, so it could be a RNA-binding protein	IPR000169;IPR001300;IPR001876;IPR022684	6650	calpain 15 [Source:HGNC Symbol;Acc:HGNC:11182]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	$#ENSG00000103326#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9722942	$#ENSP00000219611#ENSG00000103326#ENST00000219611#Other#DZR, Peptidase_C2, zf-RanBP$#ENSP00000456017#ENSG00000103326#ENST00000562370#Other#DZR, zf-RanBP$#ENSP00000457030#ENSG00000103326#ENST00000568988#Other#$#ENSP00000490480#ENSG00000103326#ENST00000637507#Other#DZR, zf-RanBP	FALSE
1836	ENSG00000092529	CAPN3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of NF-kappaB transcription factor activity.  No indication of sequence specific DNA binding.	IPR000169;IPR001300;IPR002048;IPR018247;IPR022682;IPR022683;IPR022684	825	calpain 3 [Source:HGNC Symbol;Acc:HGNC:1480]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000092529#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:18073330	$#ENSP00000336840#ENSG00000092529#ENST00000337571#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000183936#ENSG00000092529#ENST00000349748#Other#Calpain_III, EF-hand_1, EF-hand_5, EF-hand_6, EF-h$#ENSP00000348667#ENSG00000092529#ENST00000356316#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000350181#ENSG00000092529#ENST00000357568#Other#Calpain_III, Calpain_u2, EF-hand_1, EF-hand_5, EF-$#ENSP00000380349#ENSG00000092529#ENST00000397163#Other#Calpain_III, Calpain_u2, EF-hand_1, EF-hand_5, EF-$#ENSP00000380384#ENSG00000092529#ENST00000397200#Other#Calpain_III, Calpain_u2, EF-hand_1, EF-hand_5, EF-$#ENSP00000380387#ENSG00000092529#ENST00000397204#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000456575#ENSG00000092529#ENST00000561817#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000455254#ENSG00000092529#ENST00000569136#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000457878#ENSG00000092529#ENST00000565559#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han	FALSE
1837	ENSG00000198286	CARD11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Plasma-membrane protein possibly functioning in upstream signaling of NFKB (PMID: 12154360)	IPR001315;IPR001478;IPR011029;IPR027417	84433	caspase recruitment domain family member 11 [Source:HGNC Symbol;Acc:HGNC:16393]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000198286#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12154360	$#ENSP00000380150#ENSG00000198286#ENST00000396946#Other#CARD, Guanylate_kin, PDZ$#ENSP00000347695#ENSG00000198286#ENST00000355508#Other#PDZ$#ENSP00000348779#ENSG00000198286#ENST00000356408#Other#CARD	FALSE
1838	ENSG00000141527	CARD14	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001315;IPR001478;IPR008144;IPR011029;IPR027417	79092	caspase recruitment domain family member 14 [Source:HGNC Symbol;Acc:HGNC:16446]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000141527#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21302310	$#ENSP00000344549#ENSG00000141527#ENST00000344227#Other#CARD, Guanylate_kin, PDZ$#ENSP00000461806#ENSG00000141527#ENST00000570421#Other#CARD, PDZ$#ENSP00000461447#ENSG00000141527#ENST00000576785#Other#CARD	FALSE
1839	ENSG00000138380	CARF	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac-only motif.  Major evidence is found in (PMID: 11832226).  Cloned by Y1H and binding demonstrated by gel-shift.  Mutant probes do not compete.  DNA binding ability seems solid but motif is sketchy.	IPR029309	79800	calcium responsive transcription factor [Source:HGNC Symbol;Acc:HGNC:14435]	None	not tested	not tested	None	None	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Jussi Taipale	Yimeng Yin	No	$#ENSG00000138380#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000138380#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:11832226	$#ENSP00000384006#ENSG00000138380#ENST00000402905#Other#ALS2CR8$#ENSP00000415948#ENSG00000138380#ENST00000434998#Other#ALS2CR8$#ENSP00000414644#ENSG00000138380#ENST00000438828#Other#ALS2CR8$#ENSP00000416812#ENSG00000138380#ENST00000444724#Other#ALS2CR8$#ENSP00000316224#ENSG00000138380#ENST00000320443#Other#ALS2CR8$#ENSP00000416160#ENSG00000138380#ENST00000414439#Other#ALS2CR8$#ENSP00000396221#ENSG00000138380#ENST00000428585#Other#ALS2CR8$#ENSP00000391617#ENSG00000138380#ENST00000414857#Other#$#ENSP00000387785#ENSG00000138380#ENST00000443740#Other#	FALSE
1840	ENSG00000118412	CASP8AP2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Pfam DBD match is a likely false-positive - did not produce a motif in PBM experiments	IPR009057;	9994	caspase 8 associated protein 2 [Source:HGNC Symbol;Acc:HGNC:1510]	None	not tested	Yes	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Tim Hughes	No	None	$#ENSP00000478179#ENSG00000118412#ENST00000551025#Other#$#ENSP00000485346#ENSG00000118412#ENST00000552401#Other#$#ENSP00000485349#ENSG00000118412#ENST00000419040#Other#	FALSE
1841	ENSG00000121691	CAT	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that breaks down hydrogen peroxide	None	847	Catalase	None	not tested	Yes	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000121691#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019$#ENSG00000121691#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000121691##Other#	FALSE
1842	ENSG00000078699	CBFA2T2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 and OCT4 are stabilized on chromatin (PMID: 27281218)	None	9139	Protein CBFA2T2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000078699#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$##ENSG00000078699##Other#	FALSE
1843	ENSG00000129993	CBFA2T3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Co-repressor - does not contact DNA (PMID: 12559562; PMID: 15203199)	IPR002893;IPR003894;IPR013289;IPR013292;IPR014896	863	CBFA2/RUNX1 translocation partner 3, core-binding factor, runt domain, alpha subunit 2, translocated	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Non-specific DNA; Other; TF PPI_PMIDS:16287841;16407974	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000129993#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$##ENSG00000129993##Other#	FALSE
1844	ENSG00000067955	CBFB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	CBFB augments the binding of RUNX to DNA, but does not itself bind DNA.  Thus; it is a cofactor.  Reviewed in (PMID:11105900).  Two citations used by GO (PMID:8351518; PMID:9751756) do not demonstrate DNA binding.	IPR003417;	865	core-binding factor, beta subunit [Source:HGNC Symbol;Acc:HGNC:1539]	1H9D	not tested	not tested	None	Structure is CBFB - RUNX1 heterodimer, CBFB does not contact DNA	a	Yes	No	Yes	2a1, Lower confidence direct evidence	Tim Hughes	Laura Campitelli	No	$#ENSG00000067955#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8351518, PMID:9751756	$#ENSP00000290858#ENSG00000067955#ENST00000290858#Other#CBF_beta$#ENSP00000415151#ENSG00000067955#ENST00000412916#Other#CBF_beta$#ENSP00000462932#ENSG00000067955#ENST00000565389#Other#CBF_beta$#ENSP00000456637#ENSG00000067955#ENST00000564034#Other#CBF_beta	FALSE
1845	ENSG00000110395	CBL	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiquitin ligase	IPR000449;IPR000980;IPR001841;IPR003153;IPR009060;IPR014741;IPR014742;IPR015940;IPR017907;IPR024159	867	Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	$#ENSG00000110395#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2030914	$#ENSP00000264033#ENSG00000110395#ENST00000264033#Other#Cbl_N, Cbl_N2, Cbl_N3, Prok-RING_4, UBA, zf-C3HC4,$#ENSP00000489556#ENSG00000110395#ENST00000634301#Other#$#ENSP00000490763#ENSG00000110395#ENST00000637974#Other#Cbl_N, Cbl_N2, Cbl_N3, Prok-RING_4, zf-C3HC4, zf-C	FALSE
1846	ENSG00000105879	CBLL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	E3-ubiquitin ligase involved in the regulation of cell adhesion (PMID: 11836526)	IPR001841;IPR017907	79872	Cbl proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:21225]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000222597#ENSG00000105879#ENST00000222597#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_5$#ENSP00000401277#ENSG00000105879#ENST00000440859#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_5$#ENSP00000401175#ENSG00000105879#ENST00000415884#Other#$#ENSP00000410615#ENSG00000105879#ENST00000420796#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_5	FALSE
1847	ENSG00000132024	CC2D1A	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	(PMID: 17714190) states that human Freud-1L bound specifically to its dual repressor element in the 5-HT1A receptor gene in vitro	IPR000008;IPR006608	54862	coiled-coil and C2 domain containing 1A [Source:HGNC Symbol;Acc:HGNC:30237]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000132024#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000132024#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000313601#ENSG00000132024#ENST00000318003#Other#C2$#ENSP00000467526#ENSG00000132024#ENST00000589606#Other#C2$#ENSP00000466586#ENSG00000132024#ENST00000587508#Other#C2	FALSE
1848	ENSG00000154222	CC2D1B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 19423080) says it binds a known locus in vivo, although lack of canonical DBDs suggests indirect DNA-binding	IPR000008;IPR006608	200014	coiled-coil and C2 domain containing 1B [Source:HGNC Symbol;Acc:HGNC:29386]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000154222#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033$#ENSG00000154222#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000395921#ENSG00000154222#ENST00000438021#Other#C2$#ENSP00000284376#ENSG00000154222#ENST00000284376#Other#C2$#ENSP00000360642#ENSG00000154222#ENST00000371586#Other#C2$#ENSP00000402440#ENSG00000154222#ENST00000450942#Other#C2	FALSE
1849	ENSG00000177352	CCDC71	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR026695;	64925	coiled-coil domain containing 71 [Source:HGNC Symbol;Acc:HGNC:25760]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000319006#ENSG00000177352#ENST00000321895#Other#CCDC71L	FALSE
1850	ENSG00000129315	CCNT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	General transcription machinery required to stimulate RNA pol II elongation (PMID: 16109377)	IPR006671;IPR013763	904	cyclin T1 [Source:HGNC Symbol;Acc:HGNC:1599]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Other_PMIDS:9499409;12588988;12177005;12588988	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Tim Hughes	No	None	$##ENSG00000129315##Other#	FALSE
1851	ENSG00000082258	CCNT2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Has low or no sequence specificity (PMID: 27899659)	IPR006671;IPR013763	905	cyclin T2 [Source:HGNC Symbol;Acc:HGNC:1600]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12037670;15563843	No	2a1, Lower confidence direct evidence	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000264157#ENSG00000082258#ENST00000264157#Other#Cyclin_N$#ENSP00000295238#ENSG00000082258#ENST00000295238#Other#Cyclin_N$#ENSP00000415120#ENSG00000082258#ENST00000438691#Other#$#ENSP00000387436#ENSG00000082258#ENST00000452521#Other#	FALSE
1852	ENSG00000135218	CD36	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002159;IPR005428	948	CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000308165#ENSG00000135218#ENST00000309881#Other#CD36$#ENSP00000378268#ENSG00000135218#ENST00000394788#Other#CD36$#ENSP00000392298#ENSG00000135218#ENST00000419819#Other#CD36$#ENSP00000411411#ENSG00000135218#ENST00000432207#Other#CD36$#ENSP00000399421#ENSG00000135218#ENST00000435819#Other#CD36$#ENSP00000410371#ENSG00000135218#ENST00000438020#Other#CD36$#ENSP00000431296#ENSG00000135218#ENST00000534394#Other#CD36$#ENSP00000409762#ENSG00000135218#ENST00000428497#Other#CD36$#ENSP00000433659#ENSG00000135218#ENST00000482059#Other#CD36$#ENSP00000435698#ENSG00000135218#ENST00000488048#Other#CD36	FALSE
1853	ENSG00000101017	CD40	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Cell surface receptor of TNF-family	IPR001368;IPR020435	958	CD40 molecule [Source:HGNC Symbol;Acc:HGNC:11919];Tumor necrosis factor receptor superfamily member	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000101017#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21410936	$#ENSP00000361350#ENSG00000101017#ENST00000372276#Other#TNFR_c6$#ENSP00000361359#ENSG00000101017#ENST00000372285#Other#TNFR_c6$#ENSP00000484074#ENSG00000101017#ENST00000620709#Other#TNFR_c6	FALSE
1854	ENSG00000102245	CD40LG	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003263;IPR006052;IPR008983;IPR021184	959	CD40 ligand [Source:HGNC Symbol;Acc:HGNC:11935]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	$#ENSG00000102245#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15067037	$#ENSP00000359662#ENSG00000102245#ENST00000370628#Other#TNF$#ENSP00000359663#ENSG00000102245#ENST00000370629#Other#TNF	FALSE
1855	ENSG00000094804	CDC6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003593;IPR015163;IPR016314;IPR027417	990	cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:14667810	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$##ENSG00000094804##Other#	FALSE
1856	ENSG00000108465	CDK5RAP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR008491	80279	CDK5 regulatory subunit associated protein 3 [Source:HGNC Symbol;Acc:HGNC:18673]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	$#ENSG00000108465#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:17785205, PMID:20228063	$#ENSP00000344683#ENSG00000108465#ENST00000338399#Other#DUF773$#ENSP00000438886#ENSG00000108465#ENST00000536708#Other#DUF773$#ENSP00000462886#ENSG00000108465#ENST00000578018#Other#DUF773$#ENSP00000463950#ENSG00000108465#ENST00000579175#Other#DUF773$#ENSP00000463431#ENSG00000108465#ENST00000583352#Other#DUF773, MbeD_MobD$#ENSP00000464286#ENSG00000108465#ENST00000583697#Other#DUF773	FALSE
1857	ENSG00000134058	CDK7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	1022	cyclin dependent kinase 7 [Source:HGNC Symbol;Acc:HGNC:1778]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:7566158;7761469;12379213	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$##ENSG00000134058##Other#	FALSE
1858	ENSG00000132964	CDK8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Mediator component	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	1024	cyclin dependent kinase 8 [Source:HGNC Symbol;Acc:HGNC:1779]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:14749387;15546612	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000132964##Other#	FALSE
1859	ENSG00000136807	CDK9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase protein. There is a structure with RNA (PDB: 5L1Z), where the CDK9 does not contact the RNA	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	100616250	cyclin dependent kinase 9 [Source:HGNC Symbol;Acc:HGNC:1780]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10656684;12063565	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000136807##Other#	FALSE
1860	ENSG00000124762	CDKN1A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003175	1026	cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15743834	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$##ENSG00000124762##Other#	FALSE
1861	ENSG00000147889	CDKN2A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein binds to and inactivates NFKB1 (PMID: 10353611)	IPR002110;IPR010868;IPR020683	1029	cyclin dependent kinase inhibitor 2A [Source:HGNC Symbol;Acc:HGNC:1787]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000147889#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:10353611	$#ENSP00000307101#ENSG00000147889#ENST00000304494#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000418915#ENSG00000147889#ENST00000498124#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000462950#ENSG00000147889#ENST00000579755#Other#P19Arf_N$#ENSP00000467857#ENSG00000147889#ENST00000498628#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000467390#ENSG00000147889#ENST00000578845#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000464952#ENSG00000147889#ENST00000494262#Other#Ank, Ank_2, Ank_4, Ank_5$#ENSP00000464202#ENSG00000147889#ENST00000579122#Other#Ank, Ank_2, Ank_4, Ank_5	FALSE
1862	ENSG00000115816	CEBPZ	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR005612;IPR016024	10153	CCAAT/enhancer binding protein zeta [Source:HGNC Symbol;Acc:HGNC:24218]	None	DBD and Full	not tested	None	None	a	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:2247079	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Tim Hughes	No	$#ENSG00000115816#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:2247079	$#ENSP00000234170#ENSG00000115816#ENST00000234170#Other#CBF, Cnd1$#ENSP00000391881#ENSG00000115816#ENST00000446769#Other#	FALSE
1863	ENSG00000159409	CELF3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Is a well established RBP	IPR000504	11189	CUGBP, Elav-like family member 3 [Source:HGNC Symbol;Acc:HGNC:11967]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000290583#ENSG00000159409#ENST00000290583#Other#$#ENSP00000290585#ENSG00000159409#ENST00000290585#Other#$#ENSP00000402503#ENSG00000159409#ENST00000420342#Other#	FALSE
1864	ENSG00000115163	CENPA	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone like protein. Binds DNA in the crystal structure (PDB: 3AN2).	None	None	centromere protein A	3AN2	not tested	not tested	None	Histone like protein. Binds DNA in the crystal structure (PDB: 3AN2).	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1865	ENSG00000175279	CENPS	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPX. Protein complex has many contacts with the backbone, but only a few with the bases.	None	None	centromere protein S	4NDY	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPX. Protein complex has many contacts with the backbone, but only a few with the bases.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1866	ENSG00000102901	CENPT	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contains an archaeal histone-like fold (CBF_NFY). but at best would have low sequence specificity.  Known role in centromere assembly and lack of known sequence specificity suggest that it is unlikely to be a sequence specific TF.	IPR009072;	80152	centromere protein T [Source:HGNC Symbol;Acc:HGNC:25787]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	None	$#ENSP00000400140#ENSG00000102901#ENST00000440851#Other#Bromo_TP, CBFD_NFYB_HMF, CENP-S, CENP-T_C, CENP-T_$#ENSP00000457810#ENSG00000102901#ENST00000562787#Other#Bromo_TP, CBFD_NFYB_HMF, CENP-S, CENP-T_C, CENP-T_	FALSE
1867	ENSG00000169689	CENPX	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPS.  Protein complex has many contacts with the backbone, but only a few with the bases.	None	None	Centromere protein X	4NDY	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4NDY) in heterodimeric complex with CENPS.  Protein complex has many contacts with the backbone, but only a few with the bases.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1868	ENSG00000003402	CFLAR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001309;IPR001875;IPR011029;IPR011600;IPR015917	8837	CASP8 and FADD like apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:1876]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000003402#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000312455#ENSG00000003402#ENST00000309955#Other#DED, Peptidase_C14$#ENSP00000339335#ENSG00000003402#ENST00000341222#Other#DED$#ENSP00000345807#ENSG00000003402#ENST00000341582#Other#DED, Peptidase_C14$#ENSP00000378580#ENSG00000003402#ENST00000395148#Other#DED$#ENSP00000399420#ENSG00000003402#ENST00000423241#Other#DED, Peptidase_C14$#ENSP00000406775#ENSG00000003402#ENST00000440180#Other#DED$#ENSP00000411535#ENSG00000003402#ENST00000457277#Other#DED, Peptidase_C14$#ENSP00000339326#ENSG00000003402#ENST00000340870#Other#DED, Peptidase_C14$#ENSP00000413270#ENSG00000003402#ENST00000443227#Other#DED, Peptidase_C14$#ENSP00000469917#ENSG00000003402#ENST00000462763#Other#DED$#ENSP00000471749#ENSG00000003402#ENST00000470178#Other#DED$#ENSP00000471805#ENSG00000003402#ENST00000479953#Other#DED, Peptidase_C14$#ENSP00000409570#ENSG00000003402#ENST00000425030#Other#DED$#ENSP00000391029#ENSG00000003402#ENST00000433445#Other#DED$#ENSP00000411897#ENSG00000003402#ENST00000441224#Other#DED, HTH_5$#ENSP00000469608#ENSG00000003402#ENST00000494258#Other#DED	FALSE
1869	ENSG00000163320	CGGBP1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds unstable triplet repeat 5-d(CGG)n-3 in the human FMR1 gene (PMID: 9201980)	IPR033375	8545	CGG triplet repeat binding protein 1 [Source:HGNC Symbol;Acc:HGNC:1888];CGG triplet repeat-binding p	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000163320#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:10692448 | IMP - PMID:10692448	$#ENSP00000381428#ENSG00000163320#ENST00000309534#Other#AKAP95, Mei5, zf-C2H2_2$#ENSP00000418769#ENSG00000163320#ENST00000462901#Other#AKAP95, Mei5, zf-C2H2_2$#ENSP00000420374#ENSG00000163320#ENST00000482016#Other#AKAP95, Mei5, zf-C2H2_2$#ENSP00000381429#ENSG00000163320#ENST00000398392#Other#AKAP95, Mei5, zf-C2H2_2	FALSE
1870	ENSG00000106554	CHCHD3	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Alias FLJ20420 can specially bind the hBAG-1 promoter region by EMSA  and ChIP assays (PMID: 22567091)	IPR007964	54927	coiled-coil-helix-coiled-coil-helix domain containing 3 [Source:HGNC Symbol;Acc:HGNC:21906];MICOS co	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000106554#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:22567091	$#ENSP00000262570#ENSG00000106554#ENST00000262570#Other#CHCH, DUF737$#ENSP00000389297#ENSG00000106554#ENST00000448878#Other#CHCH, DUF737	FALSE
1871	ENSG00000153922	CHD1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	(PMID: 22033927) discusses and presents a crystal structure with DNA.  The Chd1 chromatin remodeler possesses a C-terminal DNA-binding domain that is required for efficient nucleosome sliding and believed to be essential for sensing the length of DNA flanking the nucleosome core.  Recognizes backbone only, so it has low specificity.	IPR000330;IPR000953;IPR001650;IPR014001;IPR016197;IPR023779;IPR023780;IPR025260;IPR027417;	1105	chromodomain helicase DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:1915]	3TED	Full	not tested	None	Structure is for yeast homolog, based on PMID:16263726 the protein recognizes methylated H3K4, but the yeast homolog doesnt	x	No	No	No	3a, decent circumstantial evidence for its role as	Jussi Taipale	Yimeng Yin	No	None	$#ENSP00000284049#ENSG00000153922#ENST00000284049#Other#CHDCT2, Chromo, DUF4208, Helicase_C, ResIII, SLIDE$#ENSP00000479403#ENSG00000153922#ENST00000511067#Other#DUF4208$#ENSP00000483667#ENSG00000153922#ENST00000614616#Other#CHDCT2, Chromo, DUF4208, Helicase_C, ResIII, SLIDE	FALSE
1872	ENSG00000124177	CHD6	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	ATP dependent helicase (PMID: 17027977), so it has some affinity for DNA	IPR000330;IPR000953;IPR001650;IPR002464;IPR006576;IPR014001;IPR016197;IPR023780;IPR027417;	84181	chromodomain helicase DNA binding protein 6 [Source:HGNC Symbol;Acc:HGNC:19057]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000308684#ENSG00000124177#ENST00000309279#Other#CHDCT2, Chromo, ResIII, SNF2_N$#ENSP00000362319#ENSG00000124177#ENST00000373222#Other#$#ENSP00000362330#ENSG00000124177#ENST00000373233#Other#CHDCT2, Chromo, DEAD, HDA2-3, Helicase_C, ResIII, $#ENSP00000392503#ENSG00000124177#ENST00000440647#Other#	FALSE
1873	ENSG00000171316	CHD7	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Helicase and chromodomain	IPR000330;IPR000953;IPR001650;IPR006576;IPR014001;IPR016197;IPR023780;IPR027417	55636	chromodomain helicase DNA binding protein 7 [Source:HGNC Symbol;Acc:HGNC:20626]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000437061#ENSG00000171316#ENST00000524602#Other#BRK$#ENSP00000436492#ENSG00000171316#ENST00000526846#Other#$#ENSP00000392028#ENSG00000171316#ENST00000423902#Other#BRK, CHDCT2, Chromo, Helicase_C, ResIII, SNF2_N$#ENSP00000436027#ENSG00000171316#ENST00000525508#Other#Chromo, DEAD, ResIII, SNF2_N	FALSE
1874	ENSG00000177200	CHD9	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	None	IPR000330;IPR000953;IPR001650;IPR006576;IPR014001;IPR016197;IPR023780;IPR027417	80205	chromodomain helicase DNA binding protein 9 [Source:HGNC Symbol;Acc:HGNC:25701]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000381522#ENSG00000177200#ENST00000398510#Other#BRK, CHDCT2, Chromo, DEAD, Helicase_C, Peptidase_M$#ENSP00000455307#ENSG00000177200#ENST00000564845#Other#BRK, CHDCT2, Chromo, DEAD, Helicase_C, ResIII, SNF$#ENSP00000456793#ENSG00000177200#ENST00000565832#Other#$#ENSP00000457466#ENSG00000177200#ENST00000566029#Other#BRK, CHDCT2, Chromo, DEAD, Helicase_C, ResIII, SNF$#ENSP00000482842#ENSG00000177200#ENST00000622617#Other#BRK, cIII$#ENSP00000457929#ENSG00000177200#ENST00000563410#Other#$#ENSP00000456415#ENSG00000177200#ENST00000565442#Other#$#ENSP00000460155#ENSG00000177200#ENST00000562785#Other#	FALSE
1875	ENSG00000187446	CHP1	Unknown	No	ssDNA/RNA binding	Low specificity DNA-binding protein	No motif	None	According to EMSA, binds RNA strongly, and dsDNA weakly (PMID: 22727667)	IPR002048;IPR011992	11261	calcineurin like EF-hand protein 1 [Source:HGNC Symbol;Acc:HGNC:17433]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000187446#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:10593895	$#ENSP00000335632#ENSG00000187446#ENST00000334660#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000453392#ENSG00000187446#ENST00000560965#Other#EF-hand_1, EF-hand_6, EF-hand_7$#ENSP00000454007#ENSG00000187446#ENST00000560397#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han	FALSE
1876	ENSG00000104472	CHRAC1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR003958;IPR009072	54108	chromatin accessibility complex 1 [Source:HGNC Symbol;Acc:HGNC:13544]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	None	$#ENSP00000220913#ENSG00000104472#ENST00000220913#Other#CBFD_NFYB_HMF$#ENSP00000430484#ENSG00000104472#ENST00000518971#Other#$#ENSP00000428697#ENSG00000104472#ENST00000519533#Other#CBFD_NFYB_HMF$#ENSP00000430003#ENSG00000104472#ENST00000519618#Other#	FALSE
1877	ENSG00000213341	CHUK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase that operates upstream in the signalling cascade that leads to NFKB	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441;IPR022007	1147	conserved helix-loop-helix ubiquitous kinase [Source:HGNC Symbol;Acc:HGNC:1974]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000213341#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18626576, Reactome:R-HSA-445989	$#ENSP00000359424#ENSG00000213341#ENST00000370397#Other#IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr	FALSE
1878	ENSG00000258289	CHURC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Most recent work has conclusively shown it does not bind DNA (PMID: 17610897), refuting a previous study (PMID: 14651851)	IPR009508	91612	churchill domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20099]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000448050#ENSG00000258289#ENST00000549115#Other#Churchill, zf-RRPl_C4$#ENSP00000450144#ENSG00000258289#ENST00000552002#Other#Churchill, zf-RRPl_C4$#ENSP00000450165#ENSG00000258289#ENST00000548752#Other#Churchill$#ENSP00000446610#ENSG00000258289#ENST00000551093#Other#Churchill$#ENSP00000446697#ENSG00000258289#ENST00000551947#Other#Churchill$#ENSP00000475473#ENSG00000258289#ENST00000607599#Other#Churchill$#ENSP00000449184#ENSG00000258289#ENST00000547625#Other#Churchill	FALSE
1879	ENSG00000185043	CIB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002048;IPR011992;IPR018247	10519	calcium and integrin binding 1 [Source:HGNC Symbol;Acc:HGNC:16920]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000185043#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:19854831	$#ENSP00000333873#ENSG00000185043#ENST00000328649#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000479860#ENSG00000185043#ENST00000612800#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han	FALSE
1880	ENSG00000179583	CIITA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Chromatin modifier	IPR001611;IPR003590;IPR007111;IPR008095;IPR025875;IPR027417	4261	class II, major histocompatibility complex, transactivator [Source:HGNC Symbol;Acc:HGNC:7067]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:12506036	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$##ENSG00000179583##Other#	FALSE
1881	ENSG00000138433	CIR1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019339	9541	corepressor interacting with RBPJ, 1 [Source:HGNC Symbol;Acc:HGNC:24217]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000138433#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9874765$#ENSG00000138433#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:18663143	$#ENSP00000339723#ENSG00000138433#ENST00000342016#Other#Cir_N$#ENSP00000367211#ENSG00000138433#ENST00000377973#Other#zf-CCHC_6	FALSE
1882	ENSG00000125931	CITED1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Known co-activator.  GO says its sequence-specific DNA binding transcription factor activity NAS - PMID: 8901575 but this reference does not show this.	IPR007576	4435	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 [Source:HGNC Symbol;	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:9434189;10722728	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Tim Hughes	No	$#ENSG00000125931#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8901575	$#ENSP00000246139#ENSG00000125931#ENST00000246139#Other#CITED$#ENSP00000362721#ENSG00000125931#ENST00000373619#Other#CITED$#ENSP00000414781#ENSG00000125931#ENST00000417400#Other#CITED$#ENSP00000391407#ENSG00000125931#ENST00000427412#Other#CITED$#ENSP00000407496#ENSG00000125931#ENST00000429794#Other#CITED$#ENSP00000388548#ENSG00000125931#ENST00000431381#Other#CITED$#ENSP00000403274#ENSG00000125931#ENST00000445983#Other#CITED$#ENSP00000405765#ENSG00000125931#ENST00000450875#Other#$#ENSP00000401764#ENSG00000125931#ENST00000453707#Other#CITED	FALSE
1883	ENSG00000164442	CITED2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR007576	10370	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 [Source:HGNC Symbol;	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI; Transactivation_PMIDS:9434189;11044621;12778114	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000164442#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000356623#ENSG00000164442#ENST00000367651#Other#CITED$#ENSP00000479918#ENSG00000164442#ENST00000618718#Other#CITED$#ENSP00000442831#ENSG00000164442#ENST00000536159#Other#CITED$#ENSP00000444198#ENSG00000164442#ENST00000537332#Other#CITED	FALSE
1884	ENSG00000179862	CITED4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-factor	IPR007576	163732	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 [Source:HGNC Symbol;	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11744733	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$##ENSG00000179862##Other#	FALSE
1885	ENSG00000148337	CIZ1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Presence of zf-C2H2_jaz domain suggests that its likely a dsRNA binding protein	IPR000690;IPR003604;IPR007087;IPR015880;IPR022755;	25792	CDKN1A interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:16744]	None	DBD	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000362029#ENSG00000148337#ENST00000372938#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000362045#ENSG00000148337#ENST00000372954#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000377232#ENSG00000148337#ENST00000393608#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000398011#ENSG00000148337#ENST00000415526#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000362039#ENSG00000148337#ENST00000372948#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000489129#ENSG00000148337#ENST00000471839#Other#zf-C2H2_2, zf-C2H2_4, zf-C2H2_jaz$#ENSP00000439244#ENSG00000148337#ENST00000538431#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000486816#ENSG00000148337#ENST00000629610#Other#zf-C2H2_2, zf-C2H2_jaz$#ENSP00000321780#ENSG00000148337#ENST00000324544#Other#$#ENSP00000407265#ENSG00000148337#ENST00000420484#Other#	FALSE
1886	ENSG00000120885	CLU	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of NF-kappaB transcription factor activity, but there is no DBD and no evidence of DNA binding.	IPR000753;IPR016014;IPR016015;IPR016016	102465508	clusterin [Source:HGNC Symbol;Acc:HGNC:2095]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	No	$#ENSG00000120885#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:20068069	$#ENSP00000315130#ENSG00000120885#ENST00000316403#Other#Clusterin$#ENSP00000385419#ENSG00000120885#ENST00000405140#Other#Clusterin$#ENSP00000429620#ENSG00000120885#ENST00000523500#Other#Clusterin$#ENSP00000427868#ENSG00000120885#ENST00000519472#Other#Clusterin, RE_AlwI$#ENSP00000428033#ENSG00000120885#ENST00000521770#Other#Clusterin, OGFr_N$#ENSP00000430821#ENSG00000120885#ENST00000522098#Other#Clusterin$#ENSP00000431026#ENSG00000120885#ENST00000519742#Other#Clusterin, RE_AlwI, T3SSipB$#ENSP00000429881#ENSG00000120885#ENST00000520491#Other#Clusterin, RE_AlwI, T3SSipB$#ENSP00000429087#ENSG00000120885#ENST00000522238#Other#$#ENSP00000428779#ENSG00000120885#ENST00000522413#Other#Clusterin, RE_AlwI, T3SSipB$#ENSP00000428526#ENSG00000120885#ENST00000523396#Other#Clusterin, RE_AlwI$#ENSP00000431070#ENSG00000120885#ENST00000523589#Other#Clusterin, RE_AlwI	FALSE
1887	ENSG00000174600	CMKLR1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a G protein-coupled receptor for the chemoattractant adipokine chemerin	IPR000276;IPR002258;IPR017452	1240	chemerin chemokine-like receptor 1 [Source:HGNC Symbol;Acc:HGNC:2121]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000174600#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15753205	$#ENSP00000449716#ENSG00000174600#ENST00000550402#Other#7tm_1$#ENSP00000447579#ENSG00000174600#ENST00000552995#Other#7tm_1$#ENSP00000311733#ENSG00000174600#ENST00000312143#Other#7tm_1$#ENSP00000401293#ENSG00000174600#ENST00000412676#Other#7tm_1$#ENSP00000448925#ENSG00000174600#ENST00000550573#Other#7tm_1	FALSE
1888	ENSG00000169714	CNBP	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	CNBP has a specificity for single-stranded DNA (PMID: 2562787)	IPR001878	7555	CCHC-type zinc finger nucleic acid binding protein [Source:HGNC Symbol;Acc:HGNC:13164];Cellular nucl	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000169714#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2562787	$#ENSP00000410619#ENSG00000169714#ENST00000422453#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000400444#ENSG00000169714#ENST00000446936#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000399488#ENSG00000169714#ENST00000451728#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000421323#ENSG00000169714#ENST00000502976#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000410769#ENSG00000169714#ENST00000441626#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000426223#ENSG00000169714#ENST00000500450#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_$#ENSP00000422110#ENSG00000169714#ENST00000504813#Other#zf-CCHC, zf-CCHC_2, zf-CCHC_3, zf-CCHC_4, zf-CCHC_	FALSE
1889	ENSG00000088038	CNOT3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Part of complex that de-adenylates mRNA molecules (PMID: 27746116)	IPR007207;IPR007282;IPR012270	4849	CCR4-NOT transcription complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:7879]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:10637334;15601868	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	None	$##ENSG00000088038##Other#	FALSE
1890	ENSG00000080802	CNOT4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Regulates transcription through ubiquitination of TFIID (PMID:11823428). Only contains RRM domains, with no DBDs.	None	None	CCR4-NOT transcription complex subunit 4	None	not tested	not tested	None	Regulates transcription through ubiquitination of TFIID (PMID:11823428). Only contains RRM domains, with no DBDs.	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1891	ENSG00000198791	CNOT7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID:9820826) does not support DNA-binding	IPR006941;IPR012337	29883	CCR4-NOT transcription complex subunit 7 [Source:HGNC Symbol;Acc:HGNC:14101]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000198791#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9820826	$#ENSP00000355279#ENSG00000198791#ENST00000361272#Other#CAF1$#ENSP00000430263#ENSG00000198791#ENST00000518541#Other#CAF1$#ENSP00000428147#ENSG00000198791#ENST00000519918#Other#CAF1$#ENSP00000429093#ENSG00000198791#ENST00000523917#Other#CAF1$#ENSP00000430160#ENSG00000198791#ENST00000524358#Other#CAF1	FALSE
1892	ENSG00000155508	CNOT8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Deadenylase that probably regulates genes post-transcriptionally by controlling mRNA stability (PMID: 19605561)	IPR006941;IPR012337	9337	CCR4-NOT transcription complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:9207]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000155508#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10036195	$#ENSP00000285896#ENSG00000155508#ENST00000285896#Other#CAF1$#ENSP00000384747#ENSG00000155508#ENST00000403027#Other#CAF1$#ENSP00000429882#ENSG00000155508#ENST00000521583#Other#CAF1$#ENSP00000430493#ENSG00000155508#ENST00000517876#Other#CAF1$#ENSP00000430833#ENSG00000155508#ENST00000519404#Other#CAF1$#ENSP00000428305#ENSG00000155508#ENST00000520671#Other#CAF1$#ENSP00000431034#ENSG00000155508#ENST00000521450#Other#CAF1$#ENSP00000428565#ENSG00000155508#ENST00000523698#Other#CAF1$#ENSP00000429576#ENSG00000155508#ENST00000524105#Other#CAF1$#ENSP00000429108#ENSG00000155508#ENST00000519211#Other#CAF1$#ENSP00000428842#ENSG00000155508#ENST00000519394#Other#CAF1	FALSE
1893	ENSG00000173163	COMMD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR009886;IPR017920	150684	copper metabolism domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23024];COMM domain-containing pro	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000173163#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15799966, PMID:16573520 | IMP - PMID:17	$#ENSP00000308236#ENSG00000173163#ENST00000311832#Other#COMMD1_N, COMM_domain$#ENSP00000410050#ENSG00000173163#ENST00000444166#Other#$#ENSP00000413207#ENSG00000173163#ENST00000427417#Other#COMM_domain$#ENSP00000401236#ENSG00000173163#ENST00000458337#Other#COMM_domain	FALSE
1894	ENSG00000188243	COMMD6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR009886;IPR017920	170622	COMM domain containing 6 [Source:HGNC Symbol;Acc:HGNC:24015]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000188243#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16573520	$#ENSP00000385660#ENSG00000188243#ENST00000406936#Other#COMM_domain$#ENSP00000348054#ENSG00000188243#ENST00000355801#Other#COMM_domain$#ENSP00000366845#ENSG00000188243#ENST00000377619#Other#COMM_domain	FALSE
1895	ENSG00000149600	COMMD7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR009886;IPR017920	149951	COMM domain containing 7 [Source:HGNC Symbol;Acc:HGNC:16223]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000149600#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15799966	$#ENSP00000278980#ENSG00000149600#ENST00000278980#Other#COMM_domain$#ENSP00000395339#ENSG00000149600#ENST00000446419#Other#COMM_domain$#ENSP00000476443#ENSG00000149600#ENST00000474815#Other#	FALSE
1896	ENSG00000166200	COPS2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000717;IPR013143	9318	COP9 signalosome subunit 2 [Source:HGNC Symbol;Acc:HGNC:30747]	None	not tested	not tested	None	None	x	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10991940;12522100	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000299259#ENSG00000166200#ENST00000299259#Other#PCI$#ENSP00000373553#ENSG00000166200#ENST00000388901#Other#PCI$#ENSP00000452944#ENSG00000166200#ENST00000558843#Other#mRNA_stabil$#ENSP00000443664#ENSG00000166200#ENST00000542928#Other#PCI	FALSE
1897	ENSG00000141030	COPS3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase that phosphorylates JUN and possibly other TFs	IPR000717;	8533	COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000268717#ENSG00000141030#ENST00000268717#Other#PCI, RasGEF, TPR_1$#ENSP00000437606#ENSG00000141030#ENST00000539941#Other#PCI, RasGEF, TPR_1$#ENSP00000466153#ENSG00000141030#ENST00000579716#Other#	FALSE
1898	ENSG00000138663	COPS4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000717;	51138	COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000264389#ENSG00000138663#ENST00000264389#Other#PCI$#ENSP00000425976#ENSG00000138663#ENST00000509093#Other#PCI	FALSE
1899	ENSG00000214575	CPEB1	Unknown	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	HT-SELEX motif could be an artefact of ssDNA binding activity, as CPEB1 is a well-characterized RNA-binding protein. Could not find evidence of CPEB1 DNA-binding activity in the literature	IPR000504;	64506	cytoplasmic polyadenylation element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21744]	None	not tested	not tested	None	Binding probably to single stranded DNA in HT-SELEX, is an verified RNA-binding protein	No	Yes	No	No	1a1, Direct HQ evidence	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000477715#ENSG00000214575#ENST00000615198#Other#CEBP1_N, CEBP_ZZ$#ENSP00000477557#ENSG00000214575#ENST00000617462#Other#CEBP1_N, CEBP_ZZ$#ENSP00000478598#ENSG00000214575#ENST00000617958#Other#CEBP1_N, CEBP_ZZ$#ENSP00000483590#ENSG00000214575#ENST00000618449#Other#CEBP1_N, CEBP_ZZ$#ENSP00000483857#ENSG00000214575#ENST00000611163#Other#CEBP1_N, CEBP_ZZ$#ENSP00000479625#ENSG00000214575#ENST00000616959#Other#CEBP1_N, CEBP_ZZ$#ENSP00000484549#ENSG00000214575#ENST00000620182#Other#CEBP1_N, CEBP_ZZ$#ENSP00000455044#ENSG00000214575#ENST00000568994#Other#CEBP1_N	FALSE
1900	ENSG00000005339	CREBBP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	CREBBP is a likely transcriptional co-activator based on its domains and previous experimental evidence. It has previously been shown to not bind DNA sequence-specifically (PMID: 21539536)	IPR000197;IPR000433;IPR001487;IPR003101;IPR009110;IPR010303;IPR011011;IPR013178;IPR014744;IPR018359	1387	CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:8413673	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000005339#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:21539536$#ENSG00000005339#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7913207	$#ENSP00000262367#ENSG00000005339#ENST00000262367#Other#Bromodomain, Creb_binding, DUF902, HAT_KAT11, KIX,$#ENSP00000371502#ENSG00000005339#ENST00000382070#Other#Bromodomain, Creb_binding, DUF902, HAT_KAT11, KIX,$#ENSP00000459490#ENSG00000005339#ENST00000571826#Other#KIX$#ENSP00000490244#ENSG00000005339#ENST00000637492#Other#Vps36-NZF-N, ZZ	FALSE
1901	ENSG00000143162	CREG1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Regulates transcription in tethering assays (PMID: 9710587). Unlikely to be a TF, based on the lack of a canonical DBD	IPR012349;IPR014631	8804	cellular repressor of E1A stimulated genes 1 [Source:HGNC Symbol;Acc:HGNC:2351]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:9710587	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000143162##Other#	FALSE
1902	ENSG00000105662	CRTC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR024783;IPR024784;IPR024785	23373	CREB regulated transcription coactivator 1 [Source:HGNC Symbol;Acc:HGNC:16062]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000105662#GO:0032793#positive regulation of CREB transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000323332#ENSG00000105662#ENST00000321949#Other#TORC_C, TORC_M, TORC_N$#ENSP00000345001#ENSG00000105662#ENST00000338797#Other#TORC_C, TORC_M, TORC_N$#ENSP00000468893#ENSG00000105662#ENST00000594658#Other#TORC_C, TORC_M$#ENSP00000469285#ENSG00000105662#ENST00000601916#Other#TORC_C, TORC_M	FALSE
1903	ENSG00000160741	CRTC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	CRTC2 binds CREB and does not make contacts with the DNA (PDB: 4HTM; PMID: 23213254)	IPR024783;IPR024784;IPR024785	200186	CREB regulated transcription coactivator 2 [Source:HGNC Symbol;Acc:HGNC:27301]	None	not tested	not tested	None	None	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Yimeng Yin	No	$#ENSG00000160741#GO:0032793#positive regulation of CREB transcription factor activity#IBA - GO_REF:0000033 | ISS - GO_REF:0000024	$#ENSP00000357622#ENSG00000160741#ENST00000368633#Other#TORC_C, TORC_M, TORC_N$#ENSP00000357619#ENSG00000160741#ENST00000368630#Other#TORC_C, TORC_N	FALSE
1904	ENSG00000140577	CRTC3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Evidence showing that CRTC2, which resembles CERTC3, lacks DNA-binding acitvity. Its reasonable to speculate CRTC3 also lacks ability to bind to DNA	IPR024783;IPR024784;IPR024785	64784	CREB regulated transcription coactivator 3 [Source:HGNC Symbol;Acc:HGNC:26148]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000140577#GO:0032793#positive regulation of CREB transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000268184#ENSG00000140577#ENST00000268184#Other#TORC_C, TORC_M, TORC_N$#ENSP00000452640#ENSG00000140577#ENST00000560098#Other#TORC_N$#ENSP00000416573#ENSG00000140577#ENST00000420329#Other#TORC_C, TORC_M, TORC_N$#ENSP00000452676#ENSG00000140577#ENST00000558005#Other#TORC_M	FALSE
1905	ENSG00000144655	CSRNP1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538)	IPR023260	64651	cysteine and serine rich nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:14300]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	Yes	$#ENSG00000144655#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000144655#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - PMID:17726538	$#ENSP00000273153#ENSG00000144655#ENST00000273153#Other#CSRNP_N$#ENSP00000422532#ENSG00000144655#ENST00000514182#Other#CSRNP_N	FALSE
1906	ENSG00000110925	CSRNP2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538)	IPR023260	81566	cysteine and serine rich nuclear protein 2 [Source:HGNC Symbol;Acc:HGNC:16006]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000110925#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000110925#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - PMID:17726538	$#ENSP00000228515#ENSG00000110925#ENST00000228515#Other#CSRNP_N$#ENSP00000447983#ENSG00000110925#ENST00000548206#Other#CSRNP_N$#ENSP00000447657#ENSG00000110925#ENST00000548981#Other#CSRNP_N$#ENSP00000447065#ENSG00000110925#ENST00000552899#Other#CSRNP_N	FALSE
1907	ENSG00000178662	CSRNP3	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538)	IPR023260	80034	cysteine and serine rich nuclear protein 3 [Source:HGNC Symbol;Acc:HGNC:30729]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000178662#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000178662#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - PMID:17726538	$#ENSP00000344042#ENSG00000178662#ENST00000342316#Other#CSRNP_N, Nop14	FALSE
1908	ENSG00000159692	CTBP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac-only motif with no clear source.  This is a known corepressor with a primary function in the Golgi.	IPR006139;IPR006140;IPR029752;IPR029753	1487	C-terminal binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2494]	None	not tested	not tested	None	None	No	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10567582;15834423	No	2a1, Lower confidence direct evidence	Jussi Taipale	Yimeng Yin	No	$#ENSG00000159692#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000290921#ENSG00000159692#ENST00000290921#Other#2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2$#ENSP00000372411#ENSG00000159692#ENST00000382952#Other#2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2$#ENSP00000423872#ENSG00000159692#ENST00000510568#Other#$#ENSP00000422148#ENSG00000159692#ENST00000503594#Other#2-Hacid_dh_C$#ENSP00000426470#ENSG00000159692#ENST00000514210#Other#2-Hacid_dh, 2-Hacid_dh_C$#ENSP00000422730#ENSG00000159692#ENST00000504784#Other#$#ENSP00000420983#ENSG00000159692#ENST00000513420#Other#2-Hacid_dh$#ENSP00000425053#ENSG00000159692#ENST00000515399#Other#2-Hacid_dh	FALSE
1909	ENSG00000175029	CTBP2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR006139;IPR006140;IPR029753	1488	C-terminal binding protein 2 [Source:HGNC Symbol;Acc:HGNC:2495]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11504872	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$##ENSG00000175029##Other#	FALSE
1910	ENSG00000116761	CTH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	1491	Cystathionine gamma-lyase	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000116761#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000116761##Other#	FALSE
1911	ENSG00000168036	CTNNB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	This is beta catenin - acts as co-factor with TCF/LEF	IPR000225;IPR013284;IPR016024	1499	catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9671490;11983900	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Sam Lambert	No	$#ENSG00000168036#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000168036#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:15905404	$#ENSP00000344456#ENSG00000168036#ENST00000349496#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000379486#ENSG00000168036#ENST00000396183#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000379488#ENSG00000168036#ENST00000396185#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000385604#ENSG00000168036#ENST00000405570#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE$#ENSP00000411226#ENSG00000168036#ENST00000453024#Other#Adaptin_N, Arm, Atx10homo_assoc, Cnd1, DUF3361, HE	FALSE
1912	ENSG00000178585	CTNNBIP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR009428	56998	catenin beta interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16913];Beta-catenin-interacting prot	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000178585#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18977368	$#ENSP00000366474#ENSG00000178585#ENST00000377263#Other#ICAT$#ENSP00000383696#ENSG00000178585#ENST00000400904#Other#ICAT$#ENSP00000366468#ENSG00000178585#ENST00000377258#Other#ICAT$#ENSP00000366466#ENSG00000178585#ENST00000377256#Other#ICAT	FALSE
1913	ENSG00000055130	CUL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Component of the E3-ubiquitin ligase complex (PMID: 11961546)	IPR001373;IPR016157;IPR016158;IPR016159;IPR019559;	8454	cullin 1 [Source:HGNC Symbol;Acc:HGNC:2551]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$#ENSP00000326804#ENSG00000055130#ENST00000325222#Other#Cullin, Cullin_Nedd8$#ENSP00000387160#ENSG00000055130#ENST00000409469#Other#Cullin, Cullin_Nedd8$#ENSP00000482123#ENSG00000055130#ENST00000617797#Other#Cullin, Cullin_Nedd8$#ENSP00000473318#ENSG00000055130#ENST00000602748#Other#Cullin, Cullin_Nedd8	FALSE
1914	ENSG00000108094	CUL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001373;IPR016157;IPR016158;IPR016159;IPR019559;	8453	cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	None	$#ENSP00000363881#ENSG00000108094#ENST00000374749#Other#Cullin, Cullin_Nedd8, Rio2_N$#ENSP00000363883#ENSG00000108094#ENST00000374751#Other#Cullin, Cullin_Nedd8, Rio2_N$#ENSP00000414095#ENSG00000108094#ENST00000421317#Other#Cullin, Cullin_Nedd8, Rio2_N	FALSE
1915	ENSG00000036257	CUL3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001373;IPR016157;IPR016158;IPR016159;IPR019559;	8452	cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000264414#ENSG00000036257#ENST00000264414#Other#Cullin, Cullin_Nedd8$#ENSP00000387200#ENSG00000036257#ENST00000409096#Other#Cullin, Cullin_Nedd8$#ENSP00000386525#ENSG00000036257#ENST00000409777#Other#Cullin, Cullin_Nedd8$#ENSP00000343601#ENSG00000036257#ENST00000344951#Other#Cullin, Cullin_Nedd8	FALSE
1916	ENSG00000139842	CUL4A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001373;IPR016157;IPR016158;IPR016159;IPR019559;	8451	cullin 4A [Source:HGNC Symbol;Acc:HGNC:2554]	4A0K	not tested	not tested	None	Cullin does not contact DNA in the structure but it is contacted by DDB2	x	No	No	No	3a, decent circumstantial evidence for its role as	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000322132#ENSG00000139842#ENST00000326335#Other#Cullin, Cullin_Nedd8$#ENSP00000364589#ENSG00000139842#ENST00000375440#Other#Cullin, Cullin_Nedd8$#ENSP00000364590#ENSG00000139842#ENST00000375441#Other#Cullin, Cullin_Nedd8$#ENSP00000481782#ENSG00000139842#ENST00000617546#Other#Cullin, Cullin_Nedd8$#ENSP00000480367#ENSG00000139842#ENST00000488558#Other#Cullin, SecA_SW	FALSE
1917	ENSG00000158290	CUL4B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Structure (PDB: 4A0L) shows that CUL4B is recruited to DNA and does not make direct contact with it	IPR001373;IPR016157;IPR016158;IPR016159;IPR019559;	8450	cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555]	4A0L	not tested	not tested	None	Cullin does not contact DNA in the structure but it is contacted by DDB2	x	No	No	No	3a, decent circumstantial evidence for its role as	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000360373#ENSG00000158290#ENST00000371322#Other#Cullin, Cullin_Nedd8, SecA_SW$#ENSP00000384109#ENSG00000158290#ENST00000404115#Other#Cullin, Cullin_Nedd8, SecA_SW$#ENSP00000338919#ENSG00000158290#ENST00000336592#Other#Cullin, Cullin_Nedd8, SecA_SW$#ENSP00000360374#ENSG00000158290#ENST00000371323#Other#Cullin, SecA_SW	FALSE
1918	ENSG00000166266	CUL5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001373;IPR016157;IPR016158;IPR016159;IPR019559;	8065	cullin 5 [Source:HGNC Symbol;Acc:HGNC:2556]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000376808#ENSG00000166266#ENST00000393094#Other#Cullin, Cullin_Nedd8$#ENSP00000431221#ENSG00000166266#ENST00000532782#Other#Cullin	FALSE
1919	ENSG00000083799	CYLD	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000938;IPR001394;IPR018200;IPR028889	1540	CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584];Ubiquitin carboxyl-terminal hydrola	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000083799#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18313383	$#ENSP00000381574#ENSG00000083799#ENST00000398568#Other#CAP_GLY, CYLD_phos_site, UCH$#ENSP00000462134#ENSG00000083799#ENST00000566206#Other#CAP_GLY, CYLD_phos_site, UCH$#ENSP00000457576#ENSG00000083799#ENST00000569418#Other#CAP_GLY, CYLD_phos_site, UCH$#ENSP00000457108#ENSG00000083799#ENST00000569681#Other#$#ENSP00000463197#ENSG00000083799#ENST00000562884#Other#$#ENSP00000455535#ENSG00000083799#ENST00000564634#Other#$#ENSP00000458507#ENSG00000083799#ENST00000566024#Other#	FALSE
1920	ENSG00000138061	CYP1B1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001128;IPR002401;IPR017972	1545	cytochrome P450 family 1 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2597]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000138061#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000478561#ENSG00000138061#ENST00000610745#Other#p450$#ENSP00000478839#ENSG00000138061#ENST00000490576#Other#p450$#ENSP00000479876#ENSG00000138061#ENST00000494864#Other#p450$#ENSP00000483678#ENSG00000138061#ENST00000614273#Other#p450	FALSE
1921	ENSG00000170891	CYTL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	54360	Cytokine-like protein 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000170891#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000170891##Other#	FALSE
1922	ENSG00000136848	DAB2IP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000008;IPR001849;IPR001936;IPR008936;IPR021887;IPR023152	153090	DAB2 interacting protein [Source:HGNC Symbol;Acc:HGNC:17294];Disabled homolog 2-interacting protein	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000136848#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:20154697	$#ENSP00000310827#ENSG00000136848#ENST00000309989#Other#Bacillus_HBL, C2, DUF3498, RasGAP$#ENSP00000362887#ENSG00000136848#ENST00000373782#Other#Bacillus_HBL, C2, DUF3498, PH_2, RasGAP$#ENSP00000377872#ENSG00000136848#ENST00000394340#Other#C2, PH, PH_2$#ENSP00000409327#ENSG00000136848#ENST00000436835#Other#C2, PH, PH_2	FALSE
1923	ENSG00000276644	DACH1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Binds with consensus AAWANAAAWAAWT and AATACAATTAAAT as strongest target sequences based on EMSA and SELEX (PMID: 20351289). Protein contains a winged helix structural domain (PMID: 12057194)	IPR003380;IPR009061	1602	Dachshund family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2663]	None	DBD and Full	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000276644#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033$#ENSG00000276644#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:20956529	$#ENSP00000482245#ENSG00000276644#ENST00000613252#Other#Ski_Sno$#ENSP00000482493#ENSG00000276644#ENST00000611519#Other#Ski_Sno$#ENSP00000482797#ENSG00000276644#ENST00000619232#Other#Ski_Sno$#ENSP00000481551#ENSG00000276644#ENST00000620444#Other#Macoilin, Ski_Sno	FALSE
1924	ENSG00000126733	DACH2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Related to DACH1, which can bind DNA based on EMSA and SELEX (PMID: 20351289).  Yet, the fly ortholog has been extensively studied and cannot bind DNA. (PMID: 8431945; PMID: 7821215)	IPR003380;IPR009061	117154	Dachshund family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:16814]	None	DBD and Full	not tested	None	None	a	No	No	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Yimeng Yin	No	$#ENSG00000126733#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033	$#ENSP00000362217#ENSG00000126733#ENST00000373125#Other#Ski_Sno$#ENSP00000362223#ENSG00000126733#ENST00000373131#Other#Ski_Sno$#ENSP00000422727#ENSG00000126733#ENST00000484479#Other#$#ENSP00000420896#ENSG00000126733#ENST00000508860#Other#$#ENSP00000421919#ENSG00000126733#ENST00000510272#Other#	FALSE
1925	ENSG00000112977	DAP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein functions in apoptotic signaling	IPR024130	1611	death-associated protein [Source:HGNC Symbol;Acc:HGNC:2672]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000112977#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:1087798	$#ENSP00000230895#ENSG00000112977#ENST00000230895#Other#DAP$#ENSP00000394163#ENSG00000112977#ENST00000432074#Other#DAP	FALSE
1926	ENSG00000204209	DAXX	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-repressor	IPR005012	1616	death-domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11799127;12529400	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000204209##Other#	FALSE
1927	ENSG00000272886	DCP1A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR010334	55802	DCP1 decapping enzyme homolog A (S. cerevisiae)	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:11836524;11836524	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000272886##Other#	FALSE
1928	ENSG00000167986	DDB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	DDB1 does not contact the DNA in the structure (PDB: 4E5Z) - contact is mediated by DDB2	IPR004871;IPR017986	1642	damage specific DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2717]	4E5Z	not tested	not tested	None	The structure is with damaged DNA and the DNA is contacted by DDB2 rather than DDB1 (Which binds to damaged DNA-presumably without base specificity)	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Non-specific DNA_PMIDS:12034848;;9418871;12145536;12034848	No	3a, decent circumstantial evidence for its role as	Yimeng Yin	Arttu Jolma	No	None	$##ENSG00000167986##Other#	FALSE
1929	ENSG00000134574	DDB2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DDB2 contacts the DNA in the (PDB: 4A0K) structure, albeit likely in a non sequence specific manner	IPR001680;IPR017986;IPR019775	1643	damage specific DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:2718]	4A0K	not tested	not tested	None	DDB2 contacts the DNA in the structure, presumably non sequence specifically	No	No	Not a TF - Evidence that it is not a TF_Single stranded RNA/DNA binding_Other_PMIDS:12826282;9418871;9418871;12145536;12034848	No	3a, decent circumstantial evidence for its role as	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000134574##Other#	FALSE
1930	ENSG00000181418	DDN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR026500	23109	dendrin [Source:HGNC Symbol;Acc:HGNC:24458]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000181418#GO:0000982#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000390590#ENSG00000181418#ENST00000421952#Other#Dendrin	FALSE
1931	ENSG00000162733	DDR2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000421;IPR000719;IPR001245;IPR002011;IPR008266;IPR008979;IPR011009;IPR020635	4921	discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:2731]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000162733#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:20564243	$#ENSP00000356898#ENSG00000162733#ENST00000367921#Other#F5_F8_type_C, Pkinase, Pkinase_Tyr$#ENSP00000356899#ENSG00000162733#ENST00000367922#Other#F5_F8_type_C, Pkinase, Pkinase_Tyr$#ENSP00000417030#ENSG00000162733#ENST00000458105#Other#$#ENSP00000396864#ENSG00000162733#ENST00000433757#Other#$#ENSP00000400309#ENSG00000162733#ENST00000446985#Other#F5_F8_type_C	FALSE
1932	ENSG00000198171	DDRGK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019153	65992	DDRGK domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16110]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000198171#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23675531	$#ENSP00000346483#ENSG00000198171#ENST00000354488#Other#DDRGK$#ENSP00000369548#ENSG00000198171#ENST00000380201#Other#DDRGK	FALSE
1933	ENSG00000215301	DDX3X	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is a RNA-helicase that can however bind both RNA and DNA (PMID: 21589879).  The interaction is presumably nonspecific and a portion of the DNA has to be single-stranded	IPR000629;IPR001650;IPR011545;IPR014001;IPR014014;IPR027417	1654	DEAD-box helicase 3, X-linked [Source:HGNC Symbol;Acc:HGNC:2745]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16818630	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000215301##Other#	FALSE
1934	ENSG00000108654	DDX5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor (PMID: 15298701)	IPR000629;IPR001650;IPR011545;IPR012587;IPR014001;IPR014014;IPR027417	100616408	DEAD-box helicase 5 [Source:HGNC Symbol;Acc:HGNC:2746]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:15464984;15657085	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$##ENSG00000108654##Other#	FALSE
1935	ENSG00000107201	DDX58	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001650;IPR011545;IPR014001;IPR021673;IPR027417	23586	DEXD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102];Probable ATP-dependent RNA helicase DDX58	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000107201#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IC - PMID:17079289	$#ENSP00000369213#ENSG00000107201#ENST00000379883#Other#CARD_2, DEAD, Helicase_C, RIG-I_C-RD, ResIII$#ENSP00000369197#ENSG00000107201#ENST00000379868#Other#AAA_22, DEAD, Helicase_C, RIG-I_C-RD, ResIII	FALSE
1936	ENSG00000124795	DEK	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. (Entrez gene summary).  So it must have some nonspecific DNA affinity.	IPR003034;IPR014876	7913	DEK proto-oncogene [Source:HGNC Symbol;Acc:HGNC:2768]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$#ENSP00000380414#ENSG00000124795#ENST00000397239#Other#DEK_C, DUF2052, SAP$#ENSP00000244776#ENSG00000124795#ENST00000244776#Other#DEK_C, DUF2052, SAP$#ENSP00000423427#ENSG00000124795#ENST00000507591#Other#DEK_C$#ENSP00000423553#ENSG00000124795#ENST00000515742#Other#	FALSE
1937	ENSG00000024526	DEPDC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Interacts with transcriptional corepressor ZNF224 (PMID: 20587513)	IPR000198;IPR000591;IPR008936;	55635	DEP domain containing 1 [Source:HGNC Symbol;Acc:HGNC:22949]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Tim Hughes	No	None	$#ENSP00000360005#ENSG00000024526#ENST00000370966#Other#DEP, RhoGAP$#ENSP00000412292#ENSG00000024526#ENST00000456315#Other#DEP, RhoGAP$#ENSP00000431477#ENSG00000024526#ENST00000525124#Other#	FALSE
1938	ENSG00000035499	DEPDC1B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein does not have known DBDs and has been shown to function as an inhibitor of a RhoA-based signaling complex (PMID: 25458010)	IPR000198;IPR000591;IPR008936;	55789	DEP domain containing 1B [Source:HGNC Symbol;Acc:HGNC:24902]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000265036#ENSG00000035499#ENST00000265036#Other#DEP, RhoGAP$#ENSP00000389101#ENSG00000035499#ENST00000453022#Other#DEP, RhoGAP	FALSE
1939	ENSG00000166153	DEPDC4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;	120863	DEP domain containing 4 [Source:HGNC Symbol;Acc:HGNC:22952]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000396234#ENSG00000166153#ENST00000416321#Other#DEP$#ENSP00000448338#ENSG00000166153#ENST00000549249#Other#DEP$#ENSP00000448385#ENSG00000166153#ENST00000550587#Other#DEP$#ENSP00000449590#ENSG00000166153#ENST00000551642#Other#DEP$#ENSP00000448728#ENSG00000166153#ENST00000548313#Other#	FALSE
1940	ENSG00000100150	DEPDC5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR027244	9681	DEP domain containing 5 [Source:HGNC Symbol;Acc:HGNC:18423]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$#ENSP00000371546#ENSG00000100150#ENST00000382112#Other#DEP, IML1$#ENSP00000383101#ENSG00000100150#ENST00000400242#Other#IML1$#ENSP00000383105#ENSG00000100150#ENST00000400246#Other#DEP, IML1$#ENSP00000383107#ENSG00000100150#ENST00000400248#Other#DEP, IML1$#ENSP00000410544#ENSG00000100150#ENST00000433147#Other#DEP$#ENSP00000440210#ENSG00000100150#ENST00000535622#Other#DEP, IML1	FALSE
1941	ENSG00000121690	DEPDC7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because Vasquerizas 2009 includes it with an x.  No DBD and no other data to support being a TF.	IPR000591;	91614	DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Tim Hughes	No	None	$#ENSP00000241051#ENSG00000121690#ENST00000241051#Other#DEP$#ENSP00000308971#ENSG00000121690#ENST00000311388#Other#DEP	FALSE
1942	ENSG00000155792	DEPTOR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR001478	64798	DEP domain containing MTOR-interacting protein [Source:HGNC Symbol;Acc:HGNC:22953]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000286234#ENSG00000155792#ENST00000286234#Other#DEP, PDZ_2$#ENSP00000430457#ENSG00000155792#ENST00000523492#Other#DEP, PDZ_2	FALSE
1943	ENSG00000134815	DHX34	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001650;IPR007502;IPR011545;IPR011709;IPR014001;IPR027417	9704	DEAH-box helicase 34 [Source:HGNC Symbol;Acc:HGNC:16719]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000331907#ENSG00000134815#ENST00000328771#Other#AAA_22, DEAD, HA2, Helicase_C, OB_NTP_bind	FALSE
1944	ENSG00000174953	DHX36	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 2N21)	None	None	DEAH-box helicase 36	2N21	not tested	not tested	None	Binds single stranded DNA in the structure (PDB: 2N21)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1945	ENSG00000204624	DISP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000731;IPR003392;IPR004869;	57540	dispatched RND transporter family member 3 [Source:HGNC Symbol;Acc:HGNC:29251]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000294484#ENSG00000204624#ENST00000294484#Other#MMPL, Patched, Sterol-sensing$#ENSP00000303400#ENSG00000204624#ENST00000304391#Other#	FALSE
1946	ENSG00000178028	DMAP1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Component of the NuA4 histone acetyltransferase (HAT) complex, which is involved in transcriptional activation of select genes, principally by acetylation of nucleosomal histones H4 and H2A (PMID: 14966270).  (PMID: 20864525) shows DNA binding is sequence independent.	IPR008468;	55929	DNA methyltransferase 1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18291]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	Yes	None	$#ENSP00000312697#ENSG00000178028#ENST00000315913#Other#DMAP1, SANT_DAMP1_like$#ENSP00000354697#ENSG00000178028#ENST00000361745#Other#DMAP1, SANT_DAMP1_like$#ENSP00000361363#ENSG00000178028#ENST00000372289#Other#DMAP1, SANT_DAMP1_like$#ENSP00000400269#ENSG00000178028#ENST00000436069#Other#$#ENSP00000402494#ENSG00000178028#ENST00000437511#Other#SANT_DAMP1_like$#ENSP00000401099#ENSG00000178028#ENST00000440641#Other#SANT_DAMP1_like$#ENSP00000409200#ENSG00000178028#ENST00000446292#Other#DMAP1, SANT_DAMP1_like	FALSE
1947	ENSG00000100206	DMC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003593;IPR010995;IPR011940;IPR013632;IPR016467;IPR020587;IPR020588;IPR027417	11144	DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000216024#ENSG00000100206#ENST00000216024#Other#AAA_25, ATPase, DUF128, HHH_5, Rad51, RecA$#ENSP00000477737#ENSG00000100206#ENST00000616615#Other#DUF128, HHH_5, Rad51, RecA$#ENSP00000412703#ENSG00000100206#ENST00000428462#Other#ATPase, DUF128, HHH_5, Rad51, RecA$#ENSP00000391385#ENSG00000100206#ENST00000439567#Other#ATPase, DUF128, HHH_5, Rad51, RecA	FALSE
1948	ENSG00000269502	DMRTC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This particular DM protein lacks the DM DBD (PMID: 16488114)	IPR031577;IPR026607	63947	DMRT like family C1 [Source:HGNC Symbol;Acc:HGNC:13910];Doublesex- and mab-3-related transcription f	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000269502#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000469615#ENSG00000269502#ENST00000596389#Other#DMRT-like$#ENSP00000471224#ENSG00000269502#ENST00000595412#Other#DMRT-like$#ENSP00000484718#ENSG00000269502#ENST00000615063#Other#DMRT-like	FALSE
1949	ENSG00000138346	DNA2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Helicase involved in genome integrity. Binds single stranded DNA in the structure (PDB: 5EAN)	None	None	DNA replication helicase/nuclease 2	5EAN	not tested	not tested	None	Helicase involved in genome integrity. Binds single stranded DNA in the structure (PDB: 5EAN)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1950	ENSG00000103423	DNAJA3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein functions in a chaperone complex	IPR001305;IPR001623;IPR002939;IPR008971;IPR018253	None	DnaJ heat shock protein family (Hsp40) member A3 [Source:HGNC Symbol;Acc:HGNC:11808];DnaJ homolog subfamily A member 3, mitochondrial	None	not tested	not tested	None	Protein functions in a chaperone complex	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	None	FALSE
1951	ENSG00000168724	DNAJC21	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains a single Matrin-type or U1-type C2H2 domain, which typically binds dsRNA.  Its a known heat shock protein that may also be involved in rRNA processing.	IPR001623;IPR003604;IPR007087;IPR015880;IPR018253;IPR022755	134218	DnaJ heat shock protein family (Hsp40) member C21 [Source:HGNC Symbol;Acc:HGNC:27030]	None	not tested	not tested	None	None	c	No	No	No	1a1, Direct HQ evidence	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000343728#ENSG00000168724#ENST00000342382#Other#DnaJ, zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz$#ENSP00000371451#ENSG00000168724#ENST00000382021#Other#DnaJ, zf-C2H2_2, zf-C2H2_4, zf-C2H2_6, zf-C2H2_jaz	FALSE
1952	ENSG00000119772	DNMT3A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835).	None	None	DNA methyltransferase 3 alpha	None	not tested	not tested	None	None	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
1953	ENSG00000088305	DNMT3B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835).	None	None	DNA methyltransferase 3 beta	None	not tested	not tested	None	None	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
1954	ENSG00000142182	DNMT3L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835).	None	None	DNA methyltransferase 3 like	None	not tested	not tested	None	None	No	No	No	No	Protein added after initial stage, no initial assesment	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
1955	ENSG00000107447	DNTT	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 4I27)	None	None	DNA nucleotidylexotransferase	4I27	not tested	not tested	None	Binds single stranded DNA in the structure (PDB: 4I27)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1956	ENSG00000133884	DPF2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No evidence for DNA-binding activity - possible role in transcriptional regulation complex (PMID: 16785614)	IPR001965;IPR007087;IPR011011;IPR015880;IPR019787;IPR025750	5977	double PHD fingers 2 [Source:HGNC Symbol;Acc:HGNC:9964]	None	DBD and Full	not tested	None	None	a	No	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:7961935;7961935;10781338	No	4a, two or more datasets predict it as a TF	Tim Hughes	Laura Campitelli	No	None	$#ENSP00000436901#ENSG00000133884#ENST00000528416#Other#PHD, PHD_4, Requiem_N$#ENSP00000399714#ENSG00000133884#ENST00000415073#Other#PHD, Requiem_N$#ENSP00000435887#ENSG00000133884#ENST00000531989#Other#PHD$#ENSP00000252268#ENSG00000133884#ENST00000252268#Other#PHD, PHD_4, Requiem_N	FALSE
1957	ENSG00000117505	DR1	Unknown	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	Binds DNA as a heterotrimeric complex of TBP, DR1, and DRAP1 (PDB: 1JFI)	IPR003958;IPR009072	1810	down-regulator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:3017]	1JFI	DBD and Full	not tested	Obligate heteromultimer, with at least DR1 and als	Structure has DRAP1, DR1 and TBP	b	No	No	No	3a, decent circumstantial evidence for its role as	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000359295#ENSG00000117505#ENST00000370272#Other#CBFD_NFYB_HMF, CENP-W, Histone$#ENSP00000359290#ENSG00000117505#ENST00000370267#Other#CBFD_NFYB_HMF, CENP-W, Histone	FALSE
1958	ENSG00000175550	DRAP1	Unknown	Yes	Likely to be sequence specific TF	Obligate heteromer	No motif	None	Based on structure (PDB: 1JFI), it forms the obligate heterodimer DR1-DRAP1 that furthermore contacts TBP. Only makes contact with the minor groove in a histone-like interaction, which is probably non-specific (PMID: 11461703)	IPR003958;IPR009072	10589	DR1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:3019]	1JFI	DBD and Full	not tested	Obligate heteromultimer, with at least DR1 and als	Structure has DRAP1, DR1 and TBP	b	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12471260	Yes	3a, decent circumstantial evidence for its role as	Pratyush Das	Yimeng Yin	No	$#ENSG00000175550#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8608938	$#ENSP00000307850#ENSG00000175550#ENST00000312515#Other#CBFD_NFYB_HMF, FXMRP1_C_core, Histone$#ENSP00000432445#ENSG00000175550#ENST00000532933#Other#CBFD_NFYB_HMF, FXMRP1_C_core	FALSE
1959	ENSG00000096696	DSP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001101;IPR018159	1832	desmoplakin [Source:HGNC Symbol;Acc:HGNC:3052]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000369129#ENSG00000096696#ENST00000379802#Other#ERM, Plectin$#ENSP00000396591#ENSG00000096696#ENST00000418664#Other#ERM, Plectin	FALSE
1960	ENSG00000135144	DTX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This protein is an E3 ligase that operates in the Notch pathway	IPR001841;IPR004170;IPR018123	1840	deltex 1 [Source:HGNC Symbol;Acc:HGNC:3060]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:11226752;11564735	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$##ENSG00000135144##Other#	FALSE
1961	ENSG00000081721	DUSP12	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000340;IPR000387;IPR007087;IPR016278;IPR020422;IPR029021	11266	dual specificity phosphatase 12 [Source:HGNC Symbol;Acc:HGNC:3067]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000356920#ENSG00000081721#ENST00000367943#Other#DSPc, Init_tRNA_PT	FALSE
1962	ENSG00000107404	DVL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR001158;IPR001478;IPR003351;IPR008339;IPR024580;IPR029071;	102466740	dishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084]	None	not tested	not tested	None	None	x	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	4a, two or more datasets predict it as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000368169#ENSG00000107404#ENST00000378891#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ, PDZ_2$#ENSP00000480077#ENSG00000107404#ENST00000610709#Other#DIX, Dishevelled, Dsh_C	FALSE
1963	ENSG00000004975	DVL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	DVL2 does not have any known DBDs; or experimental evidence to suggest it is a TF.	IPR000591;IPR001158;IPR001478;IPR003351;IPR008339;IPR008341;IPR024580;IPR029071	1856	dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086]	None	not tested	not tested	None	None	x	No	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000004975#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:17593335	$#ENSP00000005340#ENSG00000004975#ENST00000005340#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ, PDZ_2$#ENSP00000459797#ENSG00000004975#ENST00000575458#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ, PDZ_2$#ENSP00000458209#ENSG00000004975#ENST00000574143#Other#DIX, Dishevelled, PDZ, PDZ_2$#ENSP00000458465#ENSG00000004975#ENST00000575086#Other#DEP, Dsh_C	FALSE
1964	ENSG00000161202	DVL3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR001158;IPR001478;IPR003351;IPR008339;IPR008342;IPR024580;IPR029071	1857	dishevelled segment polarity protein 3 [Source:HGNC Symbol;Acc:HGNC:3087]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000316054#ENSG00000161202#ENST00000313143#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ$#ENSP00000405885#ENSG00000161202#ENST00000431765#Other#DEP, DIX, Dishevelled, Dsh_C, PDZ$#ENSP00000393849#ENSG00000161202#ENST00000423300#Other#Dishevelled, PDZ, PDZ_2, Shufflon_N	FALSE
1965	ENSG00000158163	DZIP1L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a weak ProSite match for a single C2H2 ZF (Uniprot) but not a Pfam match. No experimental evidence for DNA-binding exists	IPR007087;	199221	DAZ interacting zinc finger protein 1 like [Source:HGNC Symbol;Acc:HGNC:26551]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000332148#ENSG00000158163#ENST00000327532#Other#Dzip-like_N$#ENSP00000420600#ENSG00000158163#ENST00000467030#Other#Dzip-like_N$#ENSP00000419486#ENSG00000158163#ENST00000469243#Other#Dzip-like_N$#ENSP00000417228#ENSG00000158163#ENST00000486487#Other#$#ENSP00000420051#ENSG00000158163#ENST00000492010#Other#	FALSE
1966	ENSG00000145088	EAF2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No convincing evidence that this protein binds DNA with any sequence specificity, or that this activity is required for its function.  Thus at best the current evidence is that it is a cofactor of some sort cofactor (PMID: 12446457)	IPR019194	55840	ELL associated factor 2 [Source:HGNC Symbol;Acc:HGNC:23115]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_TF PPI; Transactivation_PMIDS:12446457;16114057	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000145088#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16114057	$#ENSP00000273668#ENSG00000145088#ENST00000273668#Other#EAF$#ENSP00000410708#ENSG00000145088#ENST00000451944#Other#EAF	FALSE
1967	ENSG00000158813	EDA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Cell surface protein that can be cleaved into a secreted one	IPR006052;IPR008160;IPR008983	1896	ectodysplasin A [Source:HGNC Symbol;Acc:HGNC:3157]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000158813#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11039935	$#ENSP00000363680#ENSG00000158813#ENST00000374552#Other#Collagen, TNF$#ENSP00000363681#ENSG00000158813#ENST00000374553#Other#Collagen, TNF$#ENSP00000432585#ENSG00000158813#ENST00000524573#Other#Collagen, TNF$#ENSP00000434195#ENSG00000158813#ENST00000525810#Other#$#ENSP00000434861#ENSG00000158813#ENST00000527388#Other#$#ENSP00000340611#ENSG00000158813#ENST00000338901#Other#	FALSE
1968	ENSG00000131080	EDA2R	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity.  Not DNA binding.	IPR001368;IPR022319	60401	ectodysplasin A2 receptor [Source:HGNC Symbol;Acc:HGNC:17756]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000131080#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11039935	$#ENSP00000253392#ENSG00000131080#ENST00000253392#Other#TNFR_c6$#ENSP00000363851#ENSG00000131080#ENST00000374719#Other#TNFR_c6$#ENSP00000379365#ENSG00000131080#ENST00000396050#Other#TNFR_c6$#ENSP00000415242#ENSG00000131080#ENST00000451436#Other#TNFR_c6	FALSE
1969	ENSG00000107223	EDF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Known co-factor that binds DNA indirectly through interactions with TFs (PMID:12040021)	IPR001387;IPR010982;IPR013729;	8721	endothelial differentiation related factor 1 [Source:HGNC Symbol;Acc:HGNC:3164]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000107223#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:12040021	$#ENSP00000224073#ENSG00000107223#ENST00000224073#Other#HTH_3, HTH_31, MBF1$#ENSP00000360711#ENSG00000107223#ENST00000371648#Other#HTH_3, HTH_31, MBF1$#ENSP00000360712#ENSG00000107223#ENST00000371649#Other#HTH_3, HTH_31, MBF1	FALSE
1970	ENSG00000078401	EDN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that is processed into a secreted signaling peptide	IPR001928;IPR019764;IPR020475	1906	endothelin 1 [Source:HGNC Symbol;Acc:HGNC:3176]	None	not tested	Yes	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	$#ENSG00000078401#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:24117217	$#ENSP00000368683#ENSG00000078401#ENST00000379375#Other#Endothelin	FALSE
1971	ENSG00000074266	EED	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Affects transcription by histone modification (PMID: 16357870)	IPR001680;IPR017986;IPR019775	102465452	embryonic ectoderm development [Source:HGNC Symbol;Acc:HGNC:3188]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:9234727	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$##ENSG00000074266##Other#	FALSE
1972	ENSG00000135766	EGLN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002893;IPR005123;IPR006620	54583	egl-9 family hypoxia inducible factor 1 [Source:HGNC Symbol;Acc:HGNC:1232]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000135766#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16956324	$#ENSP00000355601#ENSG00000135766#ENST00000366641#Other#2OG-FeII_Oxy_3, 2OG-FeII_Oxy_4, zf-MYND	FALSE
1973	ENSG00000255302	EID1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	23741	EP300 interacting inhibitor of differentiation 1 [Source:HGNC Symbol;Acc:HGNC:1191]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11964378	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$##ENSG00000255302##Other#	FALSE
1974	ENSG00000176396	EID2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Associates with histone deacetylases (PMID: 12586827)	None	163126	EP300 interacting inhibitor of differentiation 2 [Source:HGNC Symbol;Acc:HGNC:28292]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14585496;14612439	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$##ENSG00000176396##Other#	FALSE
1975	ENSG00000055332	EIF2AK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR008271;IPR011009;IPR014720;IPR017441	5610	eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437];Interfe	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000055332#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15121867	$#ENSP00000385014#ENSG00000055332#ENST00000405334#Other#Kinase-like, Pkinase, Pkinase_Tyr, dsrm$#ENSP00000233057#ENSG00000055332#ENST00000233057#Other#Kinase-like, Pkinase, Pkinase_Tyr, dsrm$#ENSP00000374663#ENSG00000055332#ENST00000390013#Other#DND1_DSRM, dsrm	FALSE
1976	ENSG00000128829	EIF2AK4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR006575;IPR008271;IPR011009;IPR016135;IPR016255;IPR017441;IPR024435	440275	eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687];eIF-2-	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000128829#GO:0032792#negative regulation of CREB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000453148#ENSG00000128829#ENST00000559624#Other#Pkinase, Pkinase_Tyr, RWD$#ENSP00000263791#ENSG00000128829#ENST00000263791#Other#HGTP_anticodon2, Kdo, Kinase-like, Pkinase, Pkinas$#ENSP00000454210#ENSG00000128829#ENST00000558823#Other#DUF3734$#ENSP00000453968#ENSG00000128829#ENST00000560648#Other#RWD	FALSE
1977	ENSG00000184110	EIF3C	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000717;IPR008905	728689	eukaryotic translation initiation factor 3 subunit C [Source:HGNC Symbol;Acc:HGNC:3279]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000332604#ENSG00000184110#ENST00000331666#Other#PCI, eIF-3c_N$#ENSP00000378953#ENSG00000184110#ENST00000395587#Other#PCI, eIF-3c_N$#ENSP00000457963#ENSG00000184110#ENST00000566501#Other#PCI, eIF-3c_N$#ENSP00000457418#ENSG00000184110#ENST00000566866#Other#PCI, eIF-3c_N$#ENSP00000456416#ENSG00000184110#ENST00000564243#Other#PCI, eIF-3c_N$#ENSP00000455278#ENSG00000184110#ENST00000569690#Other#eIF-3c_N	FALSE
1978	ENSG00000205609	EIF3CL	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000717;IPR008905	728689	eukaryotic translation initiation factor 3 subunit C-like [Source:HGNC Symbol;Acc:HGNC:26347]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000370258#ENSG00000205609#ENST00000380876#Other#PCI, eIF-3c_N$#ENSP00000381917#ENSG00000205609#ENST00000398944#Other#PCI, eIF-3c_N	FALSE
1979	ENSG00000178982	EIF3K	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR005062;IPR016024	27335	eukaryotic translation initiation factor 3 subunit K [Source:HGNC Symbol;Acc:HGNC:24656]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000248342#ENSG00000178982#ENST00000248342#Other#CSN8_PSD8_EIF3K$#ENSP00000479334#ENSG00000178982#ENST00000614624#Other#CSN8_PSD8_EIF3K$#ENSP00000440999#ENSG00000178982#ENST00000538434#Other#CSN8_PSD8_EIF3K$#ENSP00000438145#ENSG00000178982#ENST00000545173#Other#CSN8_PSD8_EIF3K$#ENSP00000468231#ENSG00000178982#ENST00000592558#Other#CSN8_PSD8_EIF3K$#ENSP00000465460#ENSG00000178982#ENST00000593149#Other#CSN8_PSD8_EIF3K$#ENSP00000468525#ENSG00000178982#ENST00000588934#Other#CSN8_PSD8_EIF3K$#ENSP00000467895#ENSG00000178982#ENST00000591409#Other#CSN8_PSD8_EIF3K	FALSE
1980	ENSG00000154920	EME1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with MUS81.	None	None	essential meiotic structure-specific endonuclease 1	4P0P	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with MUS81.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1981	ENSG00000074800	ENO1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Enolase - DNA binding not shown to be direct	IPR000941;IPR020809;IPR020810;IPR020811;IPR029017;IPR029065	2023	enolase 1 [Source:HGNC Symbol;Acc:HGNC:3350]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000234590#ENSG00000074800#ENST00000234590#Other#Enolase_C, Enolase_N, MAAL_C, MR_MLE_C$#ENSP00000468392#ENSG00000074800#ENST00000489867#Other#Enolase_N$#ENSP00000466406#ENSG00000074800#ENST00000497492#Other#Enolase_C, Enolase_N	FALSE
1982	ENSG00000100393	EP300	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	p300 is an archetype cofactor.  It has many motifs, presumably because many TFs recruit it. Does not contact DNA in the structure (PDB: 3P57)	IPR000197;IPR000433;IPR001487;IPR003101;IPR009110;IPR010303;IPR013178;IPR014744;IPR018359	100302237	E1A binding protein p300 [Source:HGNC Symbol;Acc:HGNC:3373];Histone acetyltransferase p300	3P57	not tested	not tested	None	EP300 does not contact the DNA in the structure but contacts MEF2A that contacts DNA	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11481322;12586840	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Pratyush Das	No	$#ENSG00000100393#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000100393#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10518217	$#ENSP00000263253#ENSG00000100393#ENST00000263253#Other#Bromodomain, Creb_binding, DUF902, HAT_KAT11, KIX,$#ENSP00000489397#ENSG00000100393#ENST00000634690#Other#KIX, KIX_2$#ENSP00000488981#ENSG00000100393#ENST00000634728#Other#KIX	FALSE
1983	ENSG00000183495	EP400	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	Protein is a nucleosome remodeling complex component with a role in depositing the H3.3 variant histone into promoter and enhancer regions (PMID: 26669263). Its MYB-like and helicase domains are likely non-specific DNA binding domains	IPR000330;IPR001650;IPR013999;IPR014001;IPR014012;IPR017877;IPR027417;	57634	E1A binding protein p400	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000331737#ENSG00000183495#ENST00000332482#Other#EP400_N, HSA$#ENSP00000333602#ENSG00000183495#ENST00000333577#Other#EP400_N, HSA$#ENSP00000374213#ENSG00000183495#ENST00000389562#Other#EP400_N, HSA, Helicase_C, SNF2_N$#ENSP00000330620#ENSG00000183495#ENST00000330386#Other#	FALSE
1984	ENSG00000145242	EPHA5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001090;IPR001245;IPR001426;IPR001660;IPR003961;IPR008266;IPR008979;IPR009030;IPR011009;IPR013761;	2044	EPH receptor A5 [Source:HGNC Symbol;Acc:HGNC:3389];Ephrin type-A receptor 5	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000145242#GO:0032793#positive regulation of CREB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000273854#ENSG00000145242#ENST00000273854#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000346899#ENSG00000145242#ENST00000354839#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000427638#ENSG00000145242#ENST00000511294#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000478537#ENSG00000145242#ENST00000613740#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin$#ENSP00000480763#ENSG00000145242#ENST00000622150#Other#EphA2_TM, Ephrin_lbd, Ephrin_rec_like, HNH_5, Pkin	FALSE
1985	ENSG00000178567	EPM2AIP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that binds and regulates glycogen synthase allosterically (PMID: 24142699)	IPR026630	9852	EPM2A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:19735]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000178567#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000485489#ENSG00000178567#ENST00000623924#Other#$#ENSP00000485091#ENSG00000178567#ENST00000624586#Other#$#ENSP00000406027#ENSG00000178567#ENST00000322716#Other#	FALSE
1986	ENSG00000112851	ERBIN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001478;IPR001611;IPR003591;IPR025875	55914	erbb2 interacting protein [Source:HGNC Symbol;Acc:HGNC:15842]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000112851#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:16203728	$#ENSP00000284037#ENSG00000112851#ENST00000284037#Other#LRR_4, LRR_5, LRR_8, PDZ, PDZ_2$#ENSP00000370330#ENSG00000112851#ENST00000380943#Other#LRR_4, LRR_5, LRR_8, PDZ, PDZ_2$#ENSP00000426632#ENSG00000112851#ENST00000506030#Other#LRR_4, LRR_5, LRR_8, PDZ, PDZ_2$#ENSP00000370325#ENSG00000112851#ENST00000380938#Other#LRR_4, LRR_5, LRR_8$#ENSP00000397833#ENSG00000112851#ENST00000416865#Other#LRR_1, LRR_4, LRR_5, LRR_8, PDZ, PDZ_2, RsmF_methy$#ENSP00000425728#ENSG00000112851#ENST00000511671#Other#	FALSE
1987	ENSG00000082805	ERC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019018;IPR019323	23085	ELKS/RAB6-interacting/CAST family member 1 [Source:HGNC Symbol;Acc:HGNC:17072]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000082805#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:15218148	$#ENSP00000347621#ENSG00000082805#ENST00000355446#Other#ATG16, Cast, GAS, IncA, PKcGMP_CC$#ENSP00000354158#ENSG00000082805#ENST00000360905#Other#ATG16, Cast, GAS, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000380386#ENSG00000082805#ENST00000397203#Other#Cast, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000438546#ENSG00000082805#ENST00000543086#Other#Cast, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000468263#ENSG00000082805#ENST00000589028#Other#ATG16, Cast, GAS, IncA, PKcGMP_CC, RBD-FIP$#ENSP00000479523#ENSG00000082805#ENST00000611180#Other#ATG16, Cast, IncA, Spc7$#ENSP00000467196#ENSG00000082805#ENST00000539802#Other#$#ENSP00000465628#ENSG00000082805#ENST00000545318#Other#$#ENSP00000464959#ENSG00000082805#ENST00000589132#Other#	FALSE
1988	ENSG00000163161	ERCC3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 5IY6). Protein is an ATP-dependent 3-5 DNA helicase, so likely non-specific.	None	None	ERCC excision repair 3, TFIIH core complex helicase subunit	5IY6	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 5IY6). Protein is an ATP-dependent 3'-5' DNA helicase, so likely non-specific.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1989	ENSG00000175595	ERCC4	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds ssDNA at splayed DNA (PDB: 2KN7)	None	None	ERCC excision repair 4, endonuclease catalytic subunit	2KN7	not tested	not tested	None	Binds ssDNA at splayed DNA (PDB: 2KN7)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1990	ENSG00000182944	EWSR1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504;IPR001876	2130	EWS RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3508]	None	not tested	Yes	None	Makes an oncogenic fusion protein with certain ETS-family members, but it does not contain DBDs as normal gene it is likely a RBP	x	No	TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:9488465;11289149	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	No	None	$##ENSG00000182944##Other#	FALSE
1991	ENSG00000174371	EXO1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Makes contact with ssDNA bases at DNA breaks (PDB: 3QE9)	None	None	exonuclease 1	3QE9	not tested	not tested	None	Makes contact with ssDNA bases at DNA breaks (PDB: 3QE9)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1992	ENSG00000112685	EXOC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Plasma-membrane protein functioning in targeting of exocytic vesicles	IPR002909;IPR014756;IPR029175;	55770	exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000230449#ENSG00000112685#ENST00000230449#Other#Sec5, TIG$#ENSP00000406400#ENSG00000112685#ENST00000443083#Other#TIG	FALSE
1993	ENSG00000157036	EXOG	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Endo/exonuclease (5-3), endonuclease G-like. Binds DNA in the crystal structure (PDB: 5T4I), presumably non-specifically	None	None	endo/exonuclease (5'-3'), endonuclease G-like	5T4I	not tested	not tested	None	Endo/exonuclease (5'-3'), endonuclease G-like. Binds DNA in the crystal structure (PDB: 5T4I), presumably non-specifically	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1994	ENSG00000108799	EZH1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Classic polycomb protein.	IPR001005;IPR001214;IPR021654;IPR026489	2145	enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3526]	None	DBD and Full	Yes	None	Its a histone methyltransferase, not likely to have any sequence specificity	a	No	TF Gene Candidate__Transactivation_PMIDS:9214638	No	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	No	None	$#ENSP00000407869#ENSG00000108799#ENST00000415827#Other#EZH2_WD-Binding, SET$#ENSP00000404658#ENSG00000108799#ENST00000428826#Other#EZH2_WD-Binding, SET$#ENSP00000464753#ENSG00000108799#ENST00000586382#Other#EZH2_WD-Binding$#ENSP00000467871#ENSG00000108799#ENST00000585893#Other#EZH2_WD-Binding, SET$#ENSP00000465220#ENSG00000108799#ENST00000590078#Other#SET$#ENSP00000466924#ENSG00000108799#ENST00000592743#Other#EZH2_WD-Binding, SET	FALSE
1995	ENSG00000106462	EZH2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is a classic polycomb protein with no evidence of sequence specific DNA binding after years of intense study.  I dont see anything in (PMID :15520282) that supports DNA binding.	IPR001005;IPR001214;IPR021654;IPR026489	2146	enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527]	None	DBD and Full	Yes	None	Its a histone methyltransferase, not likely to have any sequence specificity	a	No	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_Non-specific DNA; TF PPI_PMIDS:15520282	No	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	No	$#ENSG00000106462#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000320147#ENSG00000106462#ENST00000320356#Other#EZH2_WD-Binding, SET$#ENSP00000223193#ENSG00000106462#ENST00000350995#Other#EZH2_WD-Binding, SET$#ENSP00000419711#ENSG00000106462#ENST00000460911#Other#EZH2_WD-Binding, SET$#ENSP00000419050#ENSG00000106462#ENST00000476773#Other#EZH2_WD-Binding, SET$#ENSP00000419856#ENSG00000106462#ENST00000483967#Other#EZH2_WD-Binding, SET	FALSE
1996	ENSG00000131944	FAAP24	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA backbone from the side of the minor groove in the crystal structure (PDB: 4BXO)	None	None	Fanconi anemia core complex associated protein 24	4BXO	not tested	not tested	None	Binds DNA backbone from the side of the minor groove in the crystal structure (PDB: 4BXO)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
1997	ENSG00000204677	FAM153C	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR023249	None	family with sequence similarity 153 member C [Source:HGNC Symbol;Acc:HGNC:33936]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000381177#ENSG00000204677#ENST00000398106#Other#FAM153$#ENSP00000424623#ENSG00000204677#ENST00000507848#Other#FAM153$#ENSP00000481919#ENSG00000204677#ENST00000620373#Other#FAM153$#ENSP00000422293#ENSG00000204677#ENST00000511856#Other#FAM153	FALSE
1998	ENSG00000144369	FAM171B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR018890;	165215	family with sequence similarity 171 member B [Source:HGNC Symbol;Acc:HGNC:29412]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000304108#ENSG00000144369#ENST00000304698#Other#IncA, Prominin, UPF0560$#ENSP00000478477#ENSG00000144369#ENST00000612606#Other#UPF0560	FALSE
1999	ENSG00000221909	FAM200A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Protein of unknown function that is conserved in animalia. Has similarities to transposases and zinc fingers, and thus could be a DNA binding protein although there is no evidence supporting this	IPR012337;IPR025398	221786	family with sequence similarity 200 member A [Source:HGNC Symbol;Acc:HGNC:25401]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000221909#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000411372#ENSG00000221909#ENST00000449309#Other#DUF4371, Dimer_Tnp_hAT$#ENSP00000386191#ENSG00000221909#ENST00000408938#Other#DUF4371	FALSE
2000	ENSG00000198690	FAN1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	FANCD2 and FANCI associated nuclease 1. Binds DNA in the crystal structure (PDB: 4REA), presumably non-specifically	None	None	None	4REA	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	None	None	No	None	None	FALSE
2001	ENSG00000187741	FANCA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Involved in DNA repair (PMID: 8896564)	None	2175	Fanconi anemia group A protein	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000187741#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000187741##Other#	FALSE
2002	ENSG00000144554	FANCD2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	DNA repair protein. Inconclusive data supporting sequence-specific binding. Binds NFKB target sites in EMSA using 293T expressing FANCD2 (PMID: 21912593). Since the protein is expressed in mammalian cells, it could still be NFKB mediated binding.	None	2177	Fanconi anemia group D2 protein	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000144554#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000144554##Other#	FALSE
2003	ENSG00000203780	FANK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Binds JUN to control its activity (PMID: 20978819), but there is no evidence that it binds DNA itself	None	92565	fibronectin type III and ankyrin repeat domains 1 [Source:HGNC Symbol;Acc:HGNC:23527]	None	not tested	not tested	None	None	No	No	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Laura Campitelli	No	None	$##ENSG00000203780##Other#	FALSE
2004	ENSG00000179115	FARSA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002319;IPR004529;IPR006195;IPR013196	2193	phenylalanyl-tRNA synthetase alpha subunit [Source:HGNC Symbol;Acc:HGNC:3592]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000320309#ENSG00000179115#ENST00000314606#Other#HTH_11, MarR_2, tRNA-synt_2, tRNA-synt_2d$#ENSP00000396548#ENSG00000179115#ENST00000423140#Other#HTH_11, MarR_2, tRNA-synt_2, tRNA-synt_2d$#ENSP00000465402#ENSG00000179115#ENST00000587981#Other#HTH_11, MarR_2$#ENSP00000468384#ENSG00000179115#ENST00000587488#Other#tRNA-synt_2, tRNA-synt_2d	FALSE
2005	ENSG00000116120	FARSB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	tRNA synthetase	IPR004531;IPR005146;IPR005147;IPR009061;IPR020825;	10056	phenylalanyl-tRNA synthetase beta subunit [Source:HGNC Symbol;Acc:HGNC:17800]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000281828#ENSG00000116120#ENST00000281828#Other#B3_4, B5	FALSE
2006	ENSG00000166147	FBN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000152;IPR000742;IPR001881;IPR009030;IPR011398;IPR013032;IPR017878;IPR018097;IPR026823;	2200	Fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$#ENSP00000325527#ENSG00000166147#ENST00000316623#Other#EGF, EGF_3, EGF_CA, FXa_inhibition, Plasmod_Pvs28,$#ENSP00000453901#ENSG00000166147#ENST00000560355#Other#	FALSE
2007	ENSG00000163013	FBXO41	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001810;	150726	F-box protein 41 [Source:HGNC Symbol;Acc:HGNC:29409]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000295133#ENSG00000163013#ENST00000295133#Other#Atg14, DUF572, F-box, F-box-like$#ENSP00000430968#ENSG00000163013#ENST00000520530#Other#Atg14, DUF572, F-box, F-box-like$#ENSP00000428646#ENSG00000163013#ENST00000521871#Other#Atg14, DUF572, F-box, F-box-like	FALSE
2008	ENSG00000168496	FEN1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Involved in DNA replication. Binds DNA in the crystal structure (PDB: 3Q8K), presumably in a non-specific manner.	None	None	flap structure-specific endonuclease 1	3Q8K	not tested	not tested	None	Involved in DNA replication. Binds DNA in the crystal structure (PDB: 3Q8K), presumably in a non-specific manner.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2009	ENSG00000151422	FER	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR000980;IPR001060;IPR001245;IPR008266;IPR011009;IPR016250;IPR017441;IPR020635	2241	FER tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3655]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000151422#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21518868	$#ENSP00000281092#ENSG00000151422#ENST00000281092#Other#FCH, Pkinase, Pkinase_Tyr, SH2$#ENSP00000394297#ENSG00000151422#ENST00000438717#Other#Pkinase, Pkinase_Tyr, SH2$#ENSP00000484767#ENSG00000151422#ENST00000618353#Other#Opy2, Pkinase, Pkinase_Tyr, SH2$#ENSP00000486048#ENSG00000151422#ENST00000628534#Other#FCH	FALSE
2010	ENSG00000102302	FGD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000219;IPR000306;IPR001849;IPR017455	2245	FYVE, RhoGEF and PH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:3663]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	None	$#ENSP00000364277#ENSG00000102302#ENST00000375135#Other#FYVE, FYVE_2, PH, PH_11, RhoGEF	FALSE
2011	ENSG00000115641	FHL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	LIM ZF proteins are unlikely to bind DNA. Experimental evidence does not support a role for FHL2 as a sequence-specific DNA-binding protein (PMID:10654935)	IPR001781	2274	four and a half LIM domains 2 [Source:HGNC Symbol;Acc:HGNC:3703]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10654935	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000115641##Other#	FALSE
2012	ENSG00000196924	FLNA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Go annotation is based on (PMID: 15684392), which shows that it binds FOXC1 and PBX1 but doesnt show evidence for binding to DNA	IPR001298;IPR001589;IPR001715;IPR014756;IPR017868	2316	filamin A [Source:HGNC Symbol;Acc:HGNC:3754]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000196924#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15684392	$#ENSP00000353467#ENSG00000196924#ENST00000360319#Other#Big_3_5, CH, DUF5060, EMP24_GP25L, Filamin, Invasi$#ENSP00000358866#ENSG00000196924#ENST00000369850#Other#Big_3_5, CH, DUF5060, EMP24_GP25L, Filamin, Invasi$#ENSP00000358872#ENSG00000196924#ENST00000369856#Other#Big_3_5, CH, DUF5060, EMP24_GP25L, Filamin, Invasi$#ENSP00000397824#ENSG00000196924#ENST00000444578#Other#DUF5060, Filamin	FALSE
2013	ENSG00000157827	FMNL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR010472;IPR010473;IPR014767;IPR014768;IPR015425;IPR016024;IPR017987;	114793	Formin like 2 [Source:HGNC Symbol;Acc:HGNC:18267]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000288670#ENSG00000157827#ENST00000288670#Other#Drf_FH3, Drf_GBD, FH2$#ENSP00000418959#ENSG00000157827#ENST00000475377#Other#FH2	FALSE
2014	ENSG00000162613	FUBP1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	ssDNA binding protein with crystal structure demonstrating binding to ssDNA (PDB: 1J4W). Its a KH domain protein - this is Levens protein, known to impact the Myc promoter.	IPR004087;IPR004088;IPR015096	8880	far upstream element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4004]	1J4W	not tested	not tested	None	Structure is with single-stranded DNA	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Matt Weirauch	Laura Campitelli	No	$#ENSG00000162613#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8125259	$#ENSP00000359804#ENSG00000162613#ENST00000370768#Other#DUF1897, KH_1, KH_2, KH_4, KH_5$#ENSP00000359803#ENSG00000162613#ENST00000370767#Other#DUF1897, KH_1, KH_2, KH_4, KH_5$#ENSP00000402630#ENSG00000162613#ENST00000421641#Other#KH_1, KH_2, KH_4	FALSE
2015	ENSG00000107164	FUBP3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Can bind single stranded DNA in a sequence specific manner (PMID: 8940189). Contans KH domains and has direct evidence it is an RNA-binding protein (PMID: 21252297)	IPR004087;IPR004088	8939	far upstream element binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4005]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000107164#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:8940189	$#ENSP00000318177#ENSG00000107164#ENST00000319725#Other#DUF1897, KH_1, KH_2, KH_4, KH_5	FALSE
2016	ENSG00000089280	FUS	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	FUS is a well-established RNA-binding protein	IPR000504;IPR001876	2521	FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11278855	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Sam Lambert	No	None	$##ENSG00000089280##Other#	FALSE
2017	ENSG00000157240	FZD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000539;IPR017981;IPR020067	8321	frizzled class receptor 1 [Source:HGNC Symbol;Acc:HGNC:4038];Frizzled-1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000157240#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10557084, PMID:14739301	$#ENSP00000287934#ENSG00000157240#ENST00000287934#Other#7tm_2, Dicty_CAR, Frizzled, Fz	FALSE
2018	ENSG00000180340	FZD2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transmembrane receptor protein that operates far upstream in the signalling cascade	IPR000539;IPR017981;IPR020067	2535	frizzled class receptor 2 [Source:HGNC Symbol;Acc:HGNC:4040]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000180340#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18929644	$#ENSP00000323901#ENSG00000180340#ENST00000315323#Other#Frizzled, Fz	FALSE
2019	ENSG00000174804	FZD4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000539;IPR017981;IPR020067	8322	frizzled class receptor 4 [Source:HGNC Symbol;Acc:HGNC:4042]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000174804#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14688793	$#ENSP00000434034#ENSG00000174804#ENST00000531380#Other#DUF5083, Frizzled, Fz	FALSE
2020	ENSG00000164930	FZD6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000539;IPR017981;IPR020067	8323	frizzled class receptor 6 [Source:HGNC Symbol;Acc:HGNC:4044]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000164930#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14747478	$#ENSP00000351605#ENSG00000164930#ENST00000358755#Other#Folate_rec, Frizzled, Fz$#ENSP00000429055#ENSG00000164930#ENST00000522566#Other#Folate_rec, Frizzled, Fz$#ENSP00000429528#ENSG00000164930#ENST00000523739#Other#Folate_rec, Frizzled, Fz	FALSE
2021	ENSG00000104064	GABPB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Evidence exists showing that GABPB1 (E4TF1-47/53) has no DNA binding activity, but can assocaite with GABPA (E4TF1-60; Ets factor) (PMID: 8441384). Crystal structure of GAPBP1 with GABPA (PDB: 1AWC)  clearly shows that the protein makes an extensive protein-protein interaction with GABPA, but does not bind DNA. Transfac PWM is a clear ETS-motif, so GABP1 is unlikely to contact DNA directly	IPR002110;IPR020683	55056	GA binding protein transcription factor beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:4074]	1AWC	not tested	not tested	None	Structure is GABPB - GABPA heterodimer, GABPB does not appear to contact DNA, but it does come close.	other	Yes	No	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Laura Campitelli	No	$#ENSG00000104064#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8441384	$#ENSP00000220429#ENSG00000104064#ENST00000220429#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000370259#ENSG00000104064#ENST00000380877#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000379728#ENSG00000104064#ENST00000396464#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000395771#ENSG00000104064#ENST00000429662#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000453463#ENSG00000104064#ENST00000560825#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000442500#ENSG00000104064#ENST00000543881#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000453578#ENSG00000104064#ENST00000558335#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000453806#ENSG00000104064#ENST00000561010#Other#	FALSE
2022	ENSG00000143458	GABPB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Obligate heteromer with GABPB1 (the alpha subunit) (PMID: 8810337), which together interact with GABPA (PMID: 8441384), but neither contacts the DNA	None	126626	GA-binding protein subunit beta-2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000143458#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000143458##Other#	FALSE
2023	ENSG00000116717	GADD45A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Doesnt have any DBDs - likely a co-factor	IPR004038;IPR029064	1647	growth arrest and DNA damage inducible alpha [Source:HGNC Symbol;Acc:HGNC:4095]	None	not tested	Yes	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10872826	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$##ENSG00000116717##Other#	FALSE
2024	ENSG00000183087	GAS6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000152;IPR000294;IPR000742;IPR001791;IPR001881;IPR009030;IPR013032;IPR013320;IPR018097	2621	Growth arrest-specific protein 6	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000183087#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18680538	$#ENSP00000331831#ENSG00000183087#ENST00000327773#Other#EGF, EGF_3, EGF_CA, FXa_inhibition, Gla, Laminin_G	FALSE
2025	ENSG00000007237	GAS7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 9736752) only shows that it has a proline-rich domain similar to the one in Oct2.  No evidence of DNA binding.	IPR001060;IPR001202;IPR001452	8522	growth arrest specific 7 [Source:HGNC Symbol;Acc:HGNC:4169]	None	Full	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Sam Lambert	No	$#ENSG00000007237#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9736752	$#ENSP00000322608#ENSG00000007237#ENST00000323816#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000407552#ENSG00000007237#ENST00000432992#Other#FCH, SH3_1, SH3_2, SH3_9, WW, WW_FCH_linker$#ENSP00000410108#ENSG00000007237#ENST00000437099#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000443265#ENSG00000007237#ENST00000542249#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000463527#ENSG00000007237#ENST00000579158#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000463873#ENSG00000007237#ENST00000580865#Other#DUF1664, FCH, WW_FCH_linker$#ENSP00000464240#ENSG00000007237#ENST00000585266#Other#DUF1664, FCH, WW, WW_FCH_linker$#ENSP00000464494#ENSG00000007237#ENST00000578599#Other#WW, WW_FCH_linker	FALSE
2026	ENSG00000005436	GCFC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	There is some evidence that this protein is an RNA-binding protein (PMID: 24304693).	IPR022783	6936	GC-rich sequence DNA-binding factor 2 [Source:HGNC Symbol;Acc:HGNC:1317]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000005436#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:9705290	$#ENSP00000318690#ENSG00000005436#ENST00000321027#Other#GCFC$#ENSP00000474481#ENSG00000005436#ENST00000470503#Other#$#ENSP00000437767#ENSG00000005436#ENST00000541687#Other#$#ENSP00000409340#ENSG00000005436#ENST00000427862#Other#GCFC$#ENSP00000475108#ENSG00000005436#ENST00000492826#Other#	FALSE
2027	ENSG00000178295	GEN1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Resolves Holliday junctions. Binds DNA in the crystal structure (PDB: 5T9J)	None	None	GEN1, Holliday junction 5' flap endonuclease	5T9J	not tested	not tested	None	Resolves Holliday junctions. Binds DNA in the crystal structure (PDB: 5T9J)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2028	ENSG00000198715	GLMP	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds GATCCGCCCGCTTGTGGCCAACTGGCTCCAGTCAC dsDNA based on EMSA (PMID: 18021396)	IPR029382	112770	glycosylated lysosomal membrane protein [Source:HGNC Symbol;Acc:HGNC:29436]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000198715#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:18021396$#ENSG00000198715#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IMP - PMID:18021396	$#ENSP00000354553#ENSG00000198715#ENST00000362007#Other#NCU-G1$#ENSP00000480936#ENSG00000198715#ENST00000614643#Other#NCU-G1$#ENSP00000479149#ENSG00000198715#ENST00000622703#Other#NCU-G1$#ENSP00000477187#ENSG00000198715#ENST00000481050#Other#NCU-G1	FALSE
2029	ENSG00000173230	GOLGB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Golgi resident transmembrane protein that regulates glycosylation of other proteins (PMID: 27226319)	None	2804	Golgin subfamily B member 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000173230#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$##ENSG00000173230##Other#	FALSE
2030	ENSG00000116580	GON4L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Prosite identifies a low-confidence Myb-like domain (e.g., cant decide between Myb, SANT, or no DBD), so its probably not a TF	IPR003822;IPR009057;IPR017877;	54856	gon-4 like [Source:HGNC Symbol;Acc:HGNC:25973]	None	DBD and Full	not tested	None	None	b	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000354322#ENSG00000116580#ENST00000361040#Other#$#ENSP00000357315#ENSG00000116580#ENST00000368331#Other#Myb_DNA-bind_6, PAH$#ENSP00000483100#ENSG00000116580#ENST00000615926#Other#Myb_DNA-bind_6, PAH$#ENSP00000481460#ENSG00000116580#ENST00000620426#Other#	FALSE
2031	ENSG00000186566	GPATCH8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000467;IPR007087;IPR022755;	23131	G-patch domain containing 8 [Source:HGNC Symbol;Acc:HGNC:29066]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000467556#ENSG00000186566#ENST00000591680#Other#G-patch, zf-C2H2_jaz, zf-met$#ENSP00000465781#ENSG00000186566#ENST00000585614#Other#G-patch, G-patch_2, zf-C2H2_2, zf-C2H2_jaz, zf-met	FALSE
2032	ENSG00000062194	GPBP1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Solid data presented in (PMID: 14612417) Also known as Vasculin.  (PMID: 26156556) also claims it has an extended AT hook.	IPR028128	65056	GC-rich promoter binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29520];Vasculin, Vasculin (also know	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000062194#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000264779#ENSG00000062194#ENST00000264779#Other#ELL, Vasculin$#ENSP00000421202#ENSG00000062194#ENST00000506184#Other#ELL, Vasculin$#ENSP00000421709#ENSG00000062194#ENST00000514387#Other#ELL, Vasculin$#ENSP00000422337#ENSG00000062194#ENST00000511209#Other#Vasculin	FALSE
2033	ENSG00000159592	GPBP1L1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Possible TF based on similarity to GPBP1. Despite its name, no available evidence for DNA binding. Could also be an RBP according to this screen (PMID: 22658674)	IPR028128	60313	GC-rich promoter binding protein 1 like 1 [Source:HGNC Symbol;Acc:HGNC:28843];Vasculin-like protein	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000159592#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000347224#ENSG00000159592#ENST00000355105#Other#Vasculin$#ENSP00000290795#ENSG00000159592#ENST00000290795#Other#Vasculin	FALSE
2034	ENSG00000164850	GPER1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000276;IPR017452	2852	G protein-coupled estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:4485]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000164850#GO:0017082#mineralocorticoid receptor activity#ISS - GO_REF:0000024	$#ENSP00000297469#ENSG00000164850#ENST00000297469#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000380277#ENSG00000164850#ENST00000397088#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000380281#ENSG00000164850#ENST00000397092#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000385151#ENSG00000164850#ENST00000401670#Other#7TM_GPCR_Srsx, 7tm_1$#ENSP00000410487#ENSG00000164850#ENST00000413368#Other#$#ENSP00000483756#ENSG00000164850#ENST00000619052#Other#	FALSE
2035	ENSG00000163328	GPR155	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR004776	151556	G protein-coupled receptor 155 [Source:HGNC Symbol;Acc:HGNC:22951]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000295500#ENSG00000163328#ENST00000295500#Other#DEP, Mem_trans$#ENSP00000376334#ENSG00000163328#ENST00000392551#Other#DEP, Mem_trans$#ENSP00000376335#ENSG00000163328#ENST00000392552#Other#DEP, Mem_trans$#ENSP00000481104#ENSG00000163328#ENST00000614352#Other#DEP, Mem_trans	FALSE
2036	ENSG00000166923	GREM1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	None	Gremlin-1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	None	None	FALSE
2037	ENSG00000113262	GRM6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000112;IPR000162;IPR000337;IPR001828;IPR011500;IPR017978;IPR017979;IPR028082	2916	glutamate metabotropic receptor 6 [Source:HGNC Symbol;Acc:HGNC:4598]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000231188#ENSG00000113262#ENST00000231188#Other#7tm_3, ANF_receptor, NCD3G, Peripla_BP_6$#ENSP00000430767#ENSG00000113262#ENST00000517717#Other#7tm_3, ANF_receptor, NCD3G, Peripla_BP_6	FALSE
2038	ENSG00000165417	GTF2A1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	General transcription factor. Binds DNA in the crystal structure (PDB: 5FUR). The protein contacts the DNA backbone as a heterotrimeric complex that also includes GTF2A2 and TBP. Has an extensive protein-protein interaction interface with the GTF2A2 (that does not contact the DNA) and will probably do nothing without it	None	None	general transcription factor IIA subunit 1	5FUR	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	None	None	No	None	None	FALSE
2039	ENSG00000242441	GTF2A1L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR004855;IPR009083;IPR009088;	11036	general transcription factor IIA subunit 1 like [Source:HGNC Symbol;Acc:HGNC:30727]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_Co-activation_PMIDS:12107178	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000384597#ENSG00000242441#ENST00000403751#Other#TFIIA$#ENSP00000387896#ENSG00000242441#ENST00000430487#Other#TFIIA$#ENSP00000421474#ENSG00000242441#ENST00000508440#Other#TFIIA	FALSE
2040	ENSG00000140307	GTF2A2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	GTF2A2 makes contacts with the DNA backbone (PDB:1NVP; PMID: 12972251), and thus is unlikely to be sequence-specific	IPR003194;IPR009083;IPR009088;IPR015871;IPR015872	2958	general transcription factor IIA subunit 2 [Source:HGNC Symbol;Acc:HGNC:4647]	1NVP	not tested	not tested	None	Structure is GTF2A2 with TBP, presumably nonspecific component of preinitiation complex	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Yimeng Yin	No	$#ENSG00000140307#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:8626665	$#ENSP00000379372#ENSG00000140307#ENST00000396060#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000379373#ENSG00000140307#ENST00000396061#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000379375#ENSG00000140307#ENST00000396063#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000418574#ENSG00000140307#ENST00000484743#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000452648#ENSG00000140307#ENST00000559706#Other#TFIIA_gamma_C, TFIIA_gamma_N$#ENSP00000379376#ENSG00000140307#ENST00000396064#Other#TFIIA_gamma_N	FALSE
2041	ENSG00000137947	GTF2B	Unknown	Yes	Known motif	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Contacts both DNA and TBP in the structure (PDB: 1C9B)	IPR000812;IPR013137;IPR013150;IPR013763;IPR023486	2959	general transcription factor IIB [Source:HGNC Symbol;Acc:HGNC:4648]	1C9B	not tested	not tested	None	Structure has really big protein DNA-interaction interface	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:12972613;15037660;1729710;1922364;15749018;8621548;9420329;10546889	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000359531#ENSG00000137947#ENST00000370500#Other#Cyclin_C, Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000402345#ENSG00000137947#ENST00000418217#Other#Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon$#ENSP00000415741#ENSG00000137947#ENST00000448623#Other#Cyclin_N, RB_B, TFIIB, TF_Zn_Ribbon	FALSE
2042	ENSG00000197265	GTF2E2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	GTF2E2 weakly binds dsDNA (PMID: 10716934) - unlikely to be sequence-specific	IPR003166;IPR016656	2961	general transcription factor IIE subunit 2 [Source:HGNC Symbol;Acc:HGNC:4651]	5IY6	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000348168#ENSG00000197265#ENST00000355904#Other#TFIIE_beta$#ENSP00000429312#ENSG00000197265#ENST00000518445#Other#TFIIE_beta$#ENSP00000429921#ENSG00000197265#ENST00000518599#Other#TFIIE_beta	FALSE
2043	ENSG00000125651	GTF2F1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5IY6)	IPR008851;IPR011039	2962	general transcription factor IIF subunit 1 [Source:HGNC Symbol;Acc:HGNC:4652]	5IY6	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Tim Hughes	No	None	$#ENSP00000377969#ENSG00000125651#ENST00000394456#Other#TFIIF_alpha$#ENSP00000469091#ENSG00000125651#ENST00000593678#Other#TFIIF_alpha$#ENSP00000471542#ENSG00000125651#ENST00000598607#Other#TFIIF_alpha$#ENSP00000471403#ENSG00000125651#ENST00000595047#Other#TFIIF_alpha	FALSE
2044	ENSG00000188342	GTF2F2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	The protein contacts DNA in the structure (PDB: 5IY6), and could thus have some specificity; DNA is contacted by domain folded from RKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELK.	IPR003196;IPR011039	2963	general transcription factor IIF subunit 2 [Source:HGNC Symbol;Acc:HGNC:4653]	5IY6	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$#ENSP00000340823#ENSG00000188342#ENST00000340473#Other#TFIIF_beta	FALSE
2045	ENSG00000110768	GTF2H1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	General transcription factor	IPR005607;IPR013876	2965	general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:15220921	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$##ENSG00000110768##Other#	FALSE
2046	ENSG00000145736	GTF2H2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GTF2H2 (p44) is part of the TFIIH complex, but does not contact the DNA based on structural evidence (PDB: 5IVW)	IPR002035;IPR004595;IPR007087;IPR007198;IPR012170;	2966	general transcription factor IIH subunit 2 [Source:HGNC Symbol;Acc:HGNC:4656]	5IVW	not tested	not tested	None	Contacts DNA in the structure with a long interaction interface, presumably nonspecific DNA-binder	x	No	No	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Arttu Jolma	No	$#ENSG00000145736#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8194529	$#ENSP00000274400#ENSG00000145736#ENST00000274400#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000328901#ENSG00000145736#ENST00000330280#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000429057#ENSG00000145736#ENST00000517900#Other#Ssl1, VWA_2$#ENSP00000473362#ENSG00000145736#ENST00000521602#Other#	FALSE
2047	ENSG00000183474	GTF2H2C	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a transcriptional co-regulator (PMID: 9880511)	IPR002035;IPR004595;IPR007087;IPR007198;IPR012170;	728340	GTF2H2 family member C [Source:HGNC Symbol;Acc:HGNC:31394]	None	not tested	not tested	None	None	x	No	TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9880511	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000370105#ENSG00000183474#ENST00000380729#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000422907#ENSG00000183474#ENST00000510979#Other#C1_4, Ssl1, VWA, VWA_2$#ENSP00000427224#ENSG00000183474#ENST00000512736#Other#Ssl1, VWA_2	FALSE
2048	ENSG00000111358	GTF2H3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Pre-initiation complex component that does not contact DNA in the structure (PDB: 5IVW)	IPR004600	2967	general transcription factor IIH subunit 3 [Source:HGNC Symbol;Acc:HGNC:4657]	5IVW	not tested	not tested	None	PIC-component	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Arttu Jolma	Pratyush Das	No	$#ENSG00000111358#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8194529	$#ENSP00000445162#ENSG00000111358#ENST00000543341#Other#Tfb4$#ENSP00000228955#ENSG00000111358#ENST00000228955#Other#Tfb4$#ENSP00000438435#ENSG00000111358#ENST00000543154#Other#Tfb4$#ENSP00000446429#ENSG00000111358#ENST00000539994#Other#Tfb4	FALSE
2049	ENSG00000213780	GTF2H4	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	General transcription factor	IPR004598	2968	general transcription factor IIH subunit 4 [Source:HGNC Symbol;Acc:HGNC:4658]	5IVW	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9118947	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$##ENSG00000213780##Other#	FALSE
2050	ENSG00000077235	GTF3C1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Component of RNA polymerase III. Binds weakly to the A-box (PMID: 8164661)	IPR007309	2975	general transcription factor IIIC subunit 1 [Source:HGNC Symbol;Acc:HGNC:4664]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_Other_PMIDS:11419933	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$##ENSG00000077235##Other#	FALSE
2051	ENSG00000115207	GTF3C2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	GTF3C2 is a general transcription factor of RNA polymerase III and there is no evidence that it binds DNA in the preinitiation complex. Transfac motifs are suspect	IPR001680;IPR017986;IPR019775	2976	general transcription factor IIIC subunit 2 [Source:HGNC Symbol;Acc:HGNC:4665]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000264720#ENSG00000115207#ENST00000264720#Other#WD40$#ENSP00000352536#ENSG00000115207#ENST00000359541#Other#WD40$#ENSP00000393429#ENSG00000115207#ENST00000454704#Other#WD40$#ENSP00000399339#ENSG00000115207#ENST00000431028#Other#$#ENSP00000409043#ENSG00000115207#ENST00000457098#Other#	FALSE
2052	ENSG00000189060	H1F0	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone. Likely a false-positive Pfam match based on the similarity of Forkhead domains to H1 domains	IPR005818;IPR005819	3005	H1 histone family member 0 [Source:HGNC Symbol;Acc:HGNC:4714]	None	not tested	not tested	None	None	x	Yes	No	No	4a, two or more datasets predict it as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000344504#ENSG00000189060#ENST00000340857#Forkhead#	FALSE
2053	ENSG00000178804	H1FOO	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Variant linker histone protein that is expressed in oocytes	IPR005818;	132243	H1 histone family member O, oocyte specific [Source:HGNC Symbol;Acc:HGNC:18463]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000319799#ENSG00000178804#ENST00000324382#Other#Linker_histone$#ENSP00000422964#ENSG00000178804#ENST00000503977#Other#	FALSE
2054	ENSG00000184897	H1FX	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone component	IPR005818;IPR005819	8971	H1 histone family member X [Source:HGNC Symbol;Acc:HGNC:4722]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000329662#ENSG00000184897#ENST00000333762#Other#Linker_histone	FALSE
2055	ENSG00000135077	HAVCR2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003599;IPR007110;IPR013106	84868	hepatitis A virus cellular receptor 2 [Source:HGNC Symbol;Acc:HGNC:18437]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000135077#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:22842346	$#ENSP00000312002#ENSG00000135077#ENST00000307851#Other#I-set, Ig_2, Ig_3, V-set, ig$#ENSP00000430328#ENSG00000135077#ENST00000524219#Other#$#ENSP00000430873#ENSG00000135077#ENST00000522593#Other#I-set, Ig_2, Ig_3, V-set, ig	FALSE
2056	ENSG00000172534	HCFC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is recruited to promoters by THAP11 and ZNF143 and probably does not bind DNA by itself (PMID: 26416877)	IPR003961;IPR006652	3054	host cell factor C1 [Source:HGNC Symbol;Acc:HGNC:4839]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12244100;15966902	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000172534#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019$#ENSG00000172534#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:8392914	$#ENSP00000309555#ENSG00000172534#ENST00000310441#Other#Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kelch_5, Kelch$#ENSP00000359001#ENSG00000172534#ENST00000369984#Other#Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kelch_5, Kelch$#ENSP00000399589#ENSG00000172534#ENST00000444191#Other#fn3	FALSE
2057	ENSG00000101336	HCK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Inhibits TP73-mediated transcription activation (PMID: 17535448)	IPR000719;IPR000980;IPR001245;IPR001452;IPR008266;IPR011009;IPR017441;IPR020635	3055	HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000101336#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:17535448	$#ENSP00000365012#ENSG00000101336#ENST00000375852#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000365022#ENSG00000101336#ENST00000375862#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000427757#ENSG00000101336#ENST00000518730#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000429848#ENSG00000101336#ENST00000520553#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000444986#ENSG00000101336#ENST00000534862#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000441169#ENSG00000101336#ENST00000538448#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9$#ENSP00000486627#ENSG00000101336#ENST00000629881#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_2, SH3_9	FALSE
2058	ENSG00000116478	HDAC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Histone deacetylase; likely to be a transcriptional cofactor.  Transfac motif is dubious, and the GO annotation (PMID: 8646880) seems to be based on remote homology to a yeast TF	IPR000286;IPR003084;IPR023801	3065	histone deacetylase 1 [Source:HGNC Symbol;Acc:HGNC:4852]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15919722	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Jussi Taipale	No	$#ENSG00000116478#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8646880	$#ENSP00000362649#ENSG00000116478#ENST00000373548#Other#Hist_deacetyl$#ENSP00000407859#ENSG00000116478#ENST00000428704#Other#Hist_deacetyl	FALSE
2059	ENSG00000100429	HDAC10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR023801	83933	histone deacetylase 10 [Source:HGNC Symbol;Acc:HGNC:18128]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA; TF PPI_PMIDS:11861901	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$##ENSG00000100429##Other#	FALSE
2060	ENSG00000196591	HDAC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR003084;IPR023801	3066	histone deacetylase 2 [Source:HGNC Symbol;Acc:HGNC:4853]	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11836251	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Yimeng Yin	No	$#ENSG00000196591#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19041327	$#ENSP00000430432#ENSG00000196591#ENST00000519065#Other#Hist_deacetyl$#ENSP00000357621#ENSG00000196591#ENST00000368632#Other#Hist_deacetyl$#ENSP00000417026#ENSG00000196591#ENST00000425835#Other#Hist_deacetyl$#ENSP00000430008#ENSG00000196591#ENST00000519108#Other#Hist_deacetyl	FALSE
2061	ENSG00000171720	HDAC3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR003084;IPR023801	8841	histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10860984;10944117;15561719	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000171720##Other#	FALSE
2062	ENSG00000068024	HDAC4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR017320;IPR019154;IPR023801;IPR024643	9759	histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15537544	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000068024#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18850004$#ENSG00000068024#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19071119	$#ENSP00000264606#ENSG00000068024#ENST00000345617#Other#HDAC4_Gln, Hist_deacetyl$#ENSP00000410551#ENSG00000068024#ENST00000430200#Other#Hist_deacetyl$#ENSP00000391226#ENSG00000068024#ENST00000445704#Other#	FALSE
2063	ENSG00000108840	HDAC5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR017320;IPR023801;IPR024643	10014	histone deacetylase 5 [Source:HGNC Symbol;Acc:HGNC:14068]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:11467738;11902574;12943985;15140878	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000108840#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19071119	$#ENSP00000337290#ENSG00000108840#ENST00000336057#Other#HDAC4_Gln, Hist_deacetyl$#ENSP00000468004#ENSG00000108840#ENST00000586802#Other#HDAC4_Gln, Hist_deacetyl$#ENSP00000465393#ENSG00000108840#ENST00000587135#Other#$#ENSP00000465227#ENSG00000108840#ENST00000588261#Other#$#ENSP00000465229#ENSG00000108840#ENST00000588703#Other#HDAC4_Gln$#ENSP00000468485#ENSG00000108840#ENST00000591714#Other#	FALSE
2064	ENSG00000094631	HDAC6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR001607;IPR023801	10013	histone deacetylase 6 [Source:HGNC Symbol;Acc:HGNC:14064]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12372765;15102857	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$##ENSG00000094631##Other#	FALSE
2065	ENSG00000061273	HDAC7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR017320;IPR023801	51564	histone deacetylase 7 [Source:HGNC Symbol;Acc:HGNC:14067]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12753745;15166223;15280364;11585834;12753745	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Arttu Jolma	No	None	$##ENSG00000061273##Other#	FALSE
2066	ENSG00000147099	HDAC8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000286;IPR003084;IPR023801	55869	histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10748112	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$##ENSG00000147099##Other#	FALSE
2067	ENSG00000048052	HDAC9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely to be a transcriptional cofactor	IPR000286;IPR017320;IPR023801;IPR024643	9734	histone deacetylase 9 [Source:HGNC Symbol;Acc:HGNC:14065]	1TQE	not tested	not tested	None	Structure has just a small peptide from HDAC9, that does not contact the DNA but contacts MEF2B through PPI	No	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:11535832;12242305	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$##ENSG00000048052##Other#	FALSE
2068	ENSG00000130589	HELZ2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR012340;IPR022966;IPR027417;	85441	helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000393257#ENSG00000130589#ENST00000427522#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, P$#ENSP00000417401#ENSG00000130589#ENST00000467148#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, P	FALSE
2069	ENSG00000064393	HIPK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor that can act as a coactivator or corepressor. Phosphorylates many transcription factors. (UniProt Q9H2X6)	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	28996	homeodomain interacting protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14402]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000064393#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000385571#ENSG00000064393#ENST00000406875#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000413724#ENSG00000064393#ENST00000428878#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000343108#ENSG00000064393#ENST00000342645#Other#APH, Kdo, Pkinase, Pkinase_Tyr	FALSE
2070	ENSG00000100084	HIRA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Histone chaperone - TUP1 homolog.	IPR001680;IPR011494;IPR017986;IPR019015;IPR019775	7290	histone cell cycle regulator [Source:HGNC Symbol;Acc:HGNC:4916]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000100084#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9731536	$#ENSP00000263208#ENSG00000100084#ENST00000263208#Other#ANAPC4_WD40, HIRA_B, Hira, Mcl1_mid, WD40$#ENSP00000345350#ENSG00000100084#ENST00000340170#Other#ANAPC4_WD40, HIRA_B, Hira, WD40	FALSE
2071	ENSG00000124610	HIST1H1A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone component	IPR005818;IPR005819	3024	histone cluster 1, H1a [Source:HGNC Symbol;Acc:HGNC:4715]	None	not tested	not tested	None	Histone_Core_Protein	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000244573#ENSG00000124610#ENST00000244573#Other#Linker_histone	FALSE
2072	ENSG00000184357	HIST1H1B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Linker histone.  To my knowledge there has been no demonstration of sequence specificity of linker histones, so I think this one should be called unlikely.	IPR005818;IPR005819	3009	histone cluster 1, H1b [Source:HGNC Symbol;Acc:HGNC:4719]	None	not tested	not tested	None	Histone_Core_Protein	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000330074#ENSG00000184357#ENST00000331442#Other#Linker_histone	FALSE
2073	ENSG00000187837	HIST1H1C	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR005818;IPR005819	3006	histone cluster 1, H1c [Source:HGNC Symbol;Acc:HGNC:4716]	None	not tested	not tested	None	Histone_Core_Protein	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000339566#ENSG00000187837#ENST00000343677#Other#Linker_histone	FALSE
2074	ENSG00000124575	HIST1H1D	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Linker histone that binds DNA as heteromeric complex with the other histone proteins	IPR005818;IPR005819	3007	histone cluster 1, H1d [Source:HGNC Symbol;Acc:HGNC:4717]	None	not tested	not tested	None	Histone_Core_Protein	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000244534#ENSG00000124575#ENST00000244534#Other#Linker_histone	FALSE
2075	ENSG00000168298	HIST1H1E	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA as heteromultimeric complex	IPR005818;IPR005819	3008	histone cluster 1, H1e [Source:HGNC Symbol;Acc:HGNC:4718]	None	Full	not tested	None	Histone_Core_Protein	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000307705#ENSG00000168298#ENST00000304218#Other#Linker_histone	FALSE
2076	ENSG00000187475	HIST1H1T	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR005818;IPR005819	3010	histone cluster 1, H1t [Source:HGNC Symbol;Acc:HGNC:4720]	None	Full	not tested	None	Histone_Core_Protein	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000341214#ENSG00000187475#ENST00000338379#Other#Linker_histone	FALSE
2077	ENSG00000179344	HLA-DQB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000353;IPR003006;IPR003597;IPR007110;IPR011162;	3119	major histocompatibility complex, class II, DQ beta 1 [Source:HGNC Symbol;Acc:HGNC:4944]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000364080#ENSG00000179344#ENST00000374943#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig$#ENSP00000382029#ENSG00000179344#ENST00000399079#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig$#ENSP00000382032#ENSG00000179344#ENST00000399082#Other#C1-set, C2-set_2, Ig_2, Ig_3, ig$#ENSP00000382034#ENSG00000179344#ENST00000399084#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig$#ENSP00000407332#ENSG00000179344#ENST00000434651#Other#C1-set, C2-set_2, Ig_3, MHC_I, MHC_II_beta, ig	FALSE
2078	ENSG00000232629	HLA-DQB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	None	major histocompatibility complex, class II, DQ beta 2 [Source:HGNC Symbol;Acc:HGNC:4944]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	None	FALSE
2079	ENSG00000196126	HLA-DRB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000353;IPR003006;IPR003597;IPR007110;IPR011162;	3123	major histocompatibility complex, class II, DR beta 1 [Source:HGNC Symbol;Acc:HGNC:4948]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000353099#ENSG00000196126#ENST00000360004#Other#C1-set, Ig_3, MHC_II_beta, ig$#ENSP00000480667#ENSG00000196126#ENST00000611060#Other#C1-set, Ig_3, MHC_II_beta, ig	FALSE
2080	ENSG00000196101	HLA-DRB3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	None	major histocompatibility complex, class II, DR beta 3	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	None	FALSE
2081	ENSG00000198502	HLA-DRB5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000353;IPR003006;IPR003597;IPR007110;IPR011162;	3127	major histocompatibility complex, class II, DR beta 5 [Source:HGNC Symbol;Acc:HGNC:4953]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000364114#ENSG00000198502#ENST00000374975#Other#C1-set, Ig_3, MHC_II_beta, ig	FALSE
2082	ENSG00000071794	HLTF	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	DNA repair protein. Even though it has 3 motifs, there is no compelling evidence that it really binds dsDNA - only single stranded DNA	IPR000330;IPR001650;IPR001841;IPR014001;IPR014905;IPR017907;IPR027417	6596	helicase like transcription factor [Source:HGNC Symbol;Acc:HGNC:11099]	4S0N	not tested	not tested	None	Structure has only small fragments of ssDNA	No	Yes	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:9427542	No	2a1, Lower confidence direct evidence	Sam Lambert	Matt Weirauch	No	$#ENSG00000071794#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$#ENSP00000308944#ENSG00000071794#ENST00000310053#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf$#ENSP00000376644#ENSG00000071794#ENST00000392912#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf$#ENSP00000420745#ENSG00000071794#ENST00000465259#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf$#ENSP00000420429#ENSG00000071794#ENST00000494055#Other#HIRAN, Helicase_C, Prok-RING_4, ResIII, SNF2_N, zf	FALSE
2083	ENSG00000100292	HMOX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Well characterized enzyme with no additional domains.  Included only because GO lists it as a regulator of TFs.  No support for DNA binding activity.	IPR002051;IPR016053;IPR016084;IPR018207	3162	heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000100292#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000100292#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000216117#ENSG00000100292#ENST00000216117#Other#Heme_oxygenase$#ENSP00000413316#ENSG00000100292#ENST00000412893#Other#Heme_oxygenase	FALSE
2084	ENSG00000135486	HNRNPA1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 1PGZ)	None	None	heterogeneous nuclear ribonucleoprotein A1	1PGZ	not tested	not tested	None	Binds single stranded DNA in the structure (PDB: 1PGZ)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2085	ENSG00000170144	HNRNPA3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is a well established RBP	IPR000504;IPR021662	100616394	heterogeneous nuclear ribonucleoprotein A3 [Source:HGNC Symbol;Acc:HGNC:24941]	None	not tested	not tested	None	None	No	No	TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding__PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$##ENSG00000170144##Other#	FALSE
2086	ENSG00000197451	HNRNPAB	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	HNRNPAB proteins are involved in pre-mRNA splicing. However; RRM domains can also constitute ssDNA binding domains	IPR000504;IPR012956	3182	Heterogeneous nuclear ribonucleoprotein A/B [Source:HGNC Symbol;Acc:HGNC:5034]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000197451#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000348093#ENSG00000197451#ENST00000355836#Other#CBFNT$#ENSP00000351108#ENSG00000197451#ENST00000358344#Other#CBFNT$#ENSP00000425031#ENSG00000197451#ENST00000504898#Other#CBFNT$#ENSP00000427465#ENSG00000197451#ENST00000506259#Other#CBFNT	FALSE
2087	ENSG00000275774	HNRNPCL2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is a well established RBP	IPR000504;IPR017347	440563	heterogeneous nuclear ribonucleoprotein C-like 2 [Source:HGNC Symbol;Acc:HGNC:48813]	None	not tested	not tested	None	None	No	No	TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Other_PMIDS:16010978;16217013	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$##ENSG00000275774##Other#	FALSE
2088	ENSG00000138668	HNRNPD	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 1WTB)	None	None	heterogeneous nuclear ribonucleoprotein D	1WTB	not tested	not tested	None	Binds single stranded DNA in the structure (PDB: 1WTB)	No	No	Probably Not a TF - No evidence that it is a TF___PMIDS:0	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2089	ENSG00000152795	HNRNPDL	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is a well established RBP	IPR000504	9987	heterogeneous nuclear ribonucleoprotein D like [Source:HGNC Symbol;Acc:HGNC:5037]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Single stranded RNA/DNA binding_Non-specific DNA_PMIDS:9538234	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$##ENSG00000152795##Other#	FALSE
2090	ENSG00000165119	HNRNPK	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is a well established RBP	IPR004087;IPR004088;IPR012987	407043	heterogeneous nuclear ribonucleoprotein K [Source:HGNC Symbol;Acc:HGNC:5044]	1J5K	not tested	not tested	None	Structure is with ssDNA	No	No	TF Gene_Single stranded RNA/DNA binding_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:8628302;8650178	Yes	3a, decent circumstantial evidence for its role as	Jussi Taipale	Yimeng Yin	No	$#ENSG00000165119#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IMP - PMID:20371611	$#ENSP00000317788#ENSG00000165119#ENST00000351839#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000353552#ENSG00000165119#ENST00000360384#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000365439#ENSG00000165119#ENST00000376263#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000365458#ENSG00000165119#ENST00000376281#Other#KH_1, KH_2, KH_4, KH_5, ROKNT$#ENSP00000473957#ENSG00000165119#ENST00000481820#Other#KH_1, KH_2	FALSE
2091	ENSG00000104824	HNRNPL	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	HNRNPL is a well-established RNA-binding protein; and the DNA-binding evidence was neither shown to be specific or direct (PMID: 11809897)	IPR000504;IPR006536	3191	heterogeneous nuclear ribonucleoprotein L [Source:HGNC Symbol;Acc:HGNC:5045]	None	not tested	not tested	None	None	No	No	TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11809897	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$##ENSG00000104824##Other#	FALSE
2092	ENSG00000153187	HNRNPU	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro (PMID: 1628625)	IPR001870;IPR003034;IPR003877;IPR013320;IPR027417	3192	heterogeneous nuclear ribonucleoprotein U [Source:HGNC Symbol;Acc:HGNC:5048]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9353307;15096513	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$##ENSG00000153187##Other#	FALSE
2093	ENSG00000127483	HP1BP3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone H1-like protein.  Binds in ChIP experiments (PMID: 27425409) and binds DNA (likely non-specifically) with HP1.	IPR005818;IPR005819	50809	heterochromatin protein 1 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:24973]	None	Full	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	None	$#ENSP00000364139#ENSG00000127483#ENST00000375000#Other#$#ENSP00000364142#ENSG00000127483#ENST00000375003#Other#Linker_histone, YL1$#ENSP00000312625#ENSG00000127483#ENST00000312239#Other#Linker_histone, SDA1, YL1$#ENSP00000402754#ENSG00000127483#ENST00000424732#Other#Linker_histone$#ENSP00000402096#ENSG00000127483#ENST00000437575#Other#$#ENSP00000401874#ENSG00000127483#ENST00000443615#Other#	FALSE
2094	ENSG00000168453	HR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	JmjC domain is not a DBD, and GO annotation is based on homology to a zinc finger motif and not experimental DNA-binding evidence (PMID: 9445480)	IPR003347	55806	hair growth associated [Source:HGNC Symbol;Acc:HGNC:5172];Lysine-specific demethylase hairless	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000168453#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9445480	$#ENSP00000370826#ENSG00000168453#ENST00000381418#Other#JmjC$#ENSP00000326765#ENSG00000168453#ENST00000312841#Other#	FALSE
2095	ENSG00000230989	HSBP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that has been shown to bind to HSF1 leading to inhibition of its trimerization and DNA-binding( PMID: 9649501).	IPR009643	3281	heat shock factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5203]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__Transactivation_PMIDS:12038984	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000230989##Other#	FALSE
2096	ENSG00000204389	HSPA1A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR013126;IPR018181;IPR029047;IPR029048	3303	heat shock protein family A (Hsp70) member 1A [Source:HGNC Symbol;Acc:HGNC:5232]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000204389#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:24790089	$#ENSP00000477378#ENSG00000204389#ENST00000608703#Other#FGGY_C, FtsA, HSP70, MreB_Mbl$#ENSP00000364802#ENSG00000204389#ENST00000375651#Other#FGGY_C, FtsA, HSP70, MreB_Mbl	FALSE
2097	ENSG00000204388	HSPA1B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR013126;IPR018181;IPR029047;IPR029048	None	heat shock protein family A (Hsp70) member 1B [Source:HGNC Symbol;Acc:HGNC:5233]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	None	FALSE
2098	ENSG00000090339	ICAM1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	3383	Intercellular adhesion molecule 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000090339#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000090339##Other#	FALSE
2099	ENSG00000163565	IFI16	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Recognizes DNA without sequence specificity (PMID: 22618232; PMID: 18472023)	IPR004020;IPR004021;IPR011029;	3428	interferon gamma inducible protein 16 [Source:HGNC Symbol;Acc:HGNC:5395]	3RNU	not tested	not tested	None	Structure has a dsDNA bound proteins, presumably nonspecific protein that recognizes dsDNA in cytosol as a part of innate immune system	other	No	No	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Matt Weirauch	No	$#ENSG00000163565#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:24413532	$#ENSP00000357113#ENSG00000163565#ENST00000368131#Other#HIN, PYRIN, tRNA_anti-codon$#ENSP00000357114#ENSG00000163565#ENST00000368132#Other#HIN, PYRIN, tRNA_anti-codon$#ENSP00000352740#ENSG00000163565#ENST00000359709#Other#HIN, PYRIN, tRNA_anti-codon$#ENSP00000456129#ENSG00000163565#ENST00000474473#Other#HIN$#ENSP00000458084#ENSG00000163565#ENST00000566111#Other#PYRIN	FALSE
2100	ENSG00000171855	IFNB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000471;IPR009079	3456	interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000369581#ENSG00000171855#ENST00000380232#Other#Interferon	FALSE
2101	ENSG00000211899	IGHM	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	None	Immunoglobulin heavy constant mu [Source:HGNC Symbol;Acc:HGNC:5541]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000211899##Other#	FALSE
2102	ENSG00000104365	IKBKB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000626;IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR022007;IPR029071	3551	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [Source:HGNC Symbol;Acc:H	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000104365#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15790681 | TAS - PMID:18626576, Reactom	$#ENSP00000430483#ENSG00000104365#ENST00000519735#Other#APH, Kdo, Pkinase, Pkinase_Tyr, YrbL-PhoP_reg$#ENSP00000430684#ENSG00000104365#ENST00000520810#Other#APH, IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr, Y$#ENSP00000404920#ENSG00000104365#ENST00000416505#Other#APH, IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr, Y$#ENSP00000427978#ENSG00000104365#ENST00000518983#Other#$#ENSP00000430868#ENSG00000104365#ENST00000520835#Other#APH, IKKbetaNEMObind, Kdo, Pkinase, Pkinase_Tyr, Y$#ENSP00000486961#ENSG00000104365#ENST00000629753#Other#APH, Kdo, Pkinase, Pkinase_Tyr, YrbL-PhoP_reg, ubi	FALSE
2103	ENSG00000269335	IKBKG	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein binds to NFKB1 to regulate its activity	IPR021063	8517	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Source:HGNC Symbol;Acc:	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000269335#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15620648 | TAS - PMID:18626576, Reactom	$#ENSP00000471166#ENSG00000269335#ENST00000594239#Other#CC2-LZ, NEMO$#ENSP00000479662#ENSG00000269335#ENST00000611071#Other#CC2-LZ, NEMO$#ENSP00000483825#ENSG00000269335#ENST00000618670#Other#CC2-LZ, NEMO$#ENSP00000390368#ENSG00000269335#ENST00000422680#Other#NEMO$#ENSP00000478616#ENSG00000269335#ENST00000611176#Other#Bacillus_HBL, CC2-LZ, ERM, NEMO$#ENSP00000484023#ENSG00000269335#ENST00000617207#Other#CC2-LZ, NEMO	FALSE
2104	ENSG00000136634	IL10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000098;IPR009079;IPR020423;IPR020443	3586	interleukin 10 [Source:HGNC Symbol;Acc:HGNC:5962]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000136634#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:7749983	$#ENSP00000412237#ENSG00000136634#ENST00000423557#Other#IL10, IL22	FALSE
2105	ENSG00000125538	IL1B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000975;IPR003294;IPR003502;IPR008996;IPR020877;IPR028142	3553	interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	$#ENSG00000125538#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10748004$#ENSG00000125538#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10383454, PMID:12958148	$#ENSP00000263341#ENSG00000125538#ENST00000263341#Other#IL1, IL1_propep$#ENSP00000407219#ENSG00000125538#ENST00000418817#Other#IL1_propep$#ENSP00000409680#ENSG00000125538#ENST00000432018#Other#IL1_propep$#ENSP00000400854#ENSG00000125538#ENST00000416750#Other#IL1_propep	FALSE
2106	ENSG00000196083	IL1RAP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	3556	Interleukin-1 receptor accessory protein	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000196083#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000196083##Other#	FALSE
2107	ENSG00000113520	IL4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Extracellular signaling molecule.  Included as a candidate only because it regulates STAT.	IPR001325;IPR002354;IPR009079;IPR018096	3565	interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	No	$#ENSG00000113520#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000231449#ENSG00000113520#ENST00000231449#Other#IL4$#ENSP00000325190#ENSG00000113520#ENST00000350025#Other#IL4$#ENSP00000480581#ENSG00000113520#ENST00000622422#Other#IL4	FALSE
2108	ENSG00000113525	IL5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	3567	Interleukin-5	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000113525#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000113525##Other#	FALSE
2109	ENSG00000136244	IL6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003573;IPR009079;IPR030473;IPR030474	3569	interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018]	4NI7	not tested	not tested	None	Structure is with a modified DNA aptamer	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000136244#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:7749983$#ENSG00000136244#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12419823	$#ENSP00000258743#ENSG00000136244#ENST00000258743#Other#IL6$#ENSP00000385718#ENSG00000136244#ENST00000401651#Other#IL6$#ENSP00000385227#ENSG00000136244#ENST00000406575#Other#IL6$#ENSP00000405150#ENSG00000136244#ENST00000426291#Other#IL6$#ENSP00000385043#ENSG00000136244#ENST00000407492#Other#IL23, IL6, Phage_int_SAM_1	FALSE
2110	ENSG00000203485	INF2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR003124;IPR010472;IPR010473;IPR014768;IPR015425;IPR016024	64423	inverted formin, FH2 and WH2 domain containing [Source:HGNC Symbol;Acc:HGNC:23791]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000381380#ENSG00000203485#ENST00000398337#Other#Drf_FH3, Drf_GBD$#ENSP00000483829#ENSG00000203485#ENST00000617571#Other#$#ENSP00000252527#ENSG00000203485#ENST00000252527#Other#FH2, WH2	FALSE
2111	ENSG00000111653	ING4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Interacts physically with p53 (PMID: 12750254).  Transfac motif is derived from ChIP-Chip data, so unclear if it can directly bind DNA	IPR001965;IPR011011;IPR019786;IPR019787;IPR024610	51147	inhibitor of growth family member 4 [Source:HGNC Symbol;Acc:HGNC:19423]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Tim Hughes	Pratyush Das	No	None	$#ENSP00000343396#ENSG00000111653#ENST00000341550#Other#ING, PHD, PHD_2, zf-HC5HC2H$#ENSP00000380024#ENSG00000111653#ENST00000396807#Other#ING, PHD, PHD_2, zf-HC5HC2H$#ENSP00000412705#ENSG00000111653#ENST00000412586#Other#ING, PHD, PHD_2, Spc7, zf-HC5HC2H$#ENSP00000414008#ENSG00000111653#ENST00000423703#Other#ING$#ENSP00000397343#ENSG00000111653#ENST00000444704#Other#ING, PHD, zf-HC5HC2H$#ENSP00000415903#ENSG00000111653#ENST00000446105#Other#ING, PHD, PHD_2, Spc7, zf-HC5HC2H$#ENSP00000480978#ENSG00000111653#ENST00000619641#Other#ING	FALSE
2112	ENSG00000254647	INS	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR004825;IPR016179;IPR022352;IPR022353	3630	insulin [Source:HGNC Symbol;Acc:HGNC:6081]	None	not tested	not tested	None	Secreted small peptide hormone	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000254647#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19727662	$#ENSP00000250971#ENSG00000254647#ENST00000250971#Other#Insulin$#ENSP00000370731#ENSG00000254647#ENST00000381330#Other#Insulin$#ENSP00000380432#ENSG00000254647#ENST00000397262#Other#Insulin$#ENSP00000424008#ENSG00000254647#ENST00000512523#Other#Insulin$#ENSP00000408400#ENSG00000254647#ENST00000421783#Other#Insulin	FALSE
2113	ENSG00000184216	IRAK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000488;IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR011029;IPR017441	100313781	interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000184216#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454$#ENSG00000184216#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10383454 | TAS - Reactome:R-HSA-445989	$#ENSP00000358991#ENSG00000184216#ENST00000369974#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000358997#ENSG00000184216#ENST00000369980#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000377291#ENSG00000184216#ENST00000393687#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000403730#ENSG00000184216#ENST00000443220#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000411809#ENSG00000184216#ENST00000455690#Other#	FALSE
2114	ENSG00000134070	IRAK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000488;IPR000719;IPR011009;IPR011029	3656	interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol;Acc:HGNC:6113]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000134070#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454$#ENSG00000134070#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454 | TAS - Reactome:R-HSA-445989	$#ENSP00000256458#ENSG00000134070#ENST00000256458#Other#Death, Pkinase, Pkinase_Tyr	FALSE
2115	ENSG00000090376	IRAK3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000488;IPR000719;IPR011009;IPR011029	102465249	interleukin 1 receptor associated kinase 3 [Source:HGNC Symbol;Acc:HGNC:17020]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000090376#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454, PMID:18156187$#ENSG00000090376#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:10383454	$#ENSP00000261233#ENSG00000090376#ENST00000261233#Other#Death, Pkinase, Pkinase_Tyr$#ENSP00000441321#ENSG00000090376#ENST00000545837#Other#$#ENSP00000409852#ENSG00000090376#ENST00000457197#Other#FTA2, Pkinase, Pkinase_Tyr	FALSE
2116	ENSG00000170604	IRF2BP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR018957;IPR022750	26145	interferon regulatory factor 2 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21728]	None	not tested	not tested	None	PMID: 18671972, supposed to be an ubiquitin ligase that associates with IRF2 and ubiquitinylates JDP2 (a Cre element binding bZIP), so it is likely a non-DNA binding corepressor	No	No	TF Gene Candidate__Co-activation_PMIDS:12799427	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$##ENSG00000170604##Other#	FALSE
2117	ENSG00000078747	ITCH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000008;IPR000569;IPR001202;IPR024928	83737	itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:13890]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Tim Hughes	No	$#ENSG00000078747#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000262650#ENSG00000078747#ENST00000262650#Other#C2, HECT, WW$#ENSP00000363998#ENSG00000078747#ENST00000374864#Other#C2, HECT, WW	FALSE
2118	ENSG00000160255	ITGB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	3689	Integrin beta-2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000160255#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000160255##Other#	FALSE
2119	ENSG00000142856	ITGB3BP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR009601	23421	integrin subunit beta 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6157]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10490654	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000142856##Other#	FALSE
2120	ENSG00000161652	IZUMO2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	IZUMO is not considered to be a DNA-binding domain	IPR029389	126123	IZUMO family member 2 [Source:HGNC Symbol;Acc:HGNC:28518];Izumo sperm-egg fusion protein 2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000161652#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000293405#ENSG00000161652#ENST00000293405#Other#IZUMO$#ENSP00000472657#ENSG00000161652#ENST00000600293#Other#IZUMO	FALSE
2121	ENSG00000077684	JADE1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	FYVE and PHD zinc fingers are unlikely to specifically-bind DNA	IPR001965;IPR011011;IPR019542;IPR019786;IPR019787	79960	jade family PHD finger 1 [Source:HGNC Symbol;Acc:HGNC:30027]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other; Transactivation_PMIDS:15502158	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$##ENSG00000077684##Other#	FALSE
2122	ENSG00000096968	JAK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is JAK from the classic JAK-STAT pathway.  It is included only because GO lists it under positive regulation of sequence-specific DNA binding transcription factor activity.  No evidence of sequence specificity - the STATs handle that.	None	3717	Tyrosine-protein kinase JAK2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Tim Hughes	No	$#ENSG00000096968#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000096968##Other#	FALSE
2123	ENSG00000152409	JMY	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Coactivator protein that associates with p300 and TP53 (PMID: 10518217).  There is no evidence that it contacts DNA itself. Functions also in actin nucleation (PMID: 19287377).	IPR003124	133746	junction mediating and regulatory protein, p53 cofactor [Source:HGNC Symbol;Acc:HGNC:28916];Junction	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000152409#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000379441#ENSG00000152409#ENST00000396137#Other#JMY, WH2, WHAMM-JMY_N	FALSE
2124	ENSG00000173801	JUP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000225;IPR013284;IPR016024	3728	junction plakoglobin [Source:HGNC Symbol;Acc:HGNC:6207]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000173801#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14661054	$#ENSP00000311113#ENSG00000173801#ENST00000310706#Other#Adaptin_N, Arm, Arm_2, Atx10homo_assoc, Cnd1, DUF3$#ENSP00000377508#ENSG00000173801#ENST00000393931#Other#Adaptin_N, Arm, Arm_2, Atx10homo_assoc, Cnd1, DUF3$#ENSP00000411449#ENSG00000173801#ENST00000420370#Other#Adaptin_N, Arm, Cnd1, HEAT, HEAT_2, HEAT_EZ$#ENSP00000401034#ENSG00000173801#ENST00000424457#Other#Adaptin_N, Arm, Cnd1, HEAT_2$#ENSP00000394146#ENSG00000173801#ENST00000437187#Other#Adaptin_N, Arm, Cnd1, HEAT, HEAT_2, HEAT_EZ$#ENSP00000409948#ENSG00000173801#ENST00000437369#Other#$#ENSP00000389886#ENSG00000173801#ENST00000449889#Other#Adaptin_N, Arm, Cnd1, HEAT, HEAT_2, HEAT_EZ$#ENSP00000468347#ENSG00000173801#ENST00000591690#Other#	FALSE
2125	ENSG00000139620	KANSL2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Protein is a component of the NSL chromatin remodelling complex	IPR025927	54934	KAT8 regulatory NSL complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:26024]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	None	$#ENSP00000415436#ENSG00000139620#ENST00000420613#Other#zf-C3Hc3H$#ENSP00000449747#ENSG00000139620#ENST00000550347#Other#zf-C3Hc3H$#ENSP00000447608#ENSG00000139620#ENST00000547087#Other#zf-C3Hc3H$#ENSP00000446493#ENSG00000139620#ENST00000548304#Other#zf-C3Hc3H	FALSE
2126	ENSG00000108773	KAT2A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase	IPR000182;IPR001487;IPR009464;IPR016181;IPR016376;IPR018359	2648	lysine acetyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:4201]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Transactivation_PMIDS:8552087;8972232;10611234	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$##ENSG00000108773##Other#	FALSE
2127	ENSG00000114166	KAT2B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Interacts with TFs to modify histones (PMID: 9707565)	IPR000182;IPR001487;IPR009464;IPR016181;IPR016376;IPR018359	8850	lysine acetyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:8638]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:8684459	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000114166##Other#	FALSE
2128	ENSG00000172977	KAT5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone acetyltransferase	IPR000953;IPR002717;IPR016181;IPR016197;IPR025995;	10524	lysine acetyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:5275]	None	Full	not tested	None	None	x	No	TF Gene Candidate__Co-activation_PMIDS:8607265	No	4a, two or more datasets predict it as a TF	Arttu Jolma	Jussi Taipale	Yes	None	$#ENSP00000340330#ENSG00000172977#ENST00000341318#Other#Acetyltransf_7, MOZ_SAS, Tudor-knot$#ENSP00000344955#ENSG00000172977#ENST00000352980#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS, Tudor-kno$#ENSP00000366245#ENSG00000172977#ENST00000377046#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS, Tudor-kno$#ENSP00000434765#ENSG00000172977#ENST00000530446#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS, Tudor-kno$#ENSP00000431819#ENSG00000172977#ENST00000534650#Other#Acetyltransf_1, Acetyltransf_7, MOZ_SAS$#ENSP00000434993#ENSG00000172977#ENST00000534681#Other#$#ENSP00000436247#ENSG00000172977#ENST00000530605#Other#Tudor-knot$#ENSP00000436012#ENSG00000172977#ENST00000531880#Other#Tudor-knot$#ENSP00000435766#ENSG00000172977#ENST00000533596#Other#MOZ_SAS	FALSE
2129	ENSG00000083168	KAT6A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone deacetylase; likely a transcriptional cofactor	IPR001965;IPR002717;IPR005818;IPR011011;IPR016181;IPR019787	7994	lysine acetyltransferase 6A [Source:HGNC Symbol;Acc:HGNC:13013]	None	not tested	not tested	None	None	x	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:16702405	No	4a, two or more datasets predict it as a TF	Matt Weirauch	Arttu Jolma	Yes	None	$#ENSP00000265713#ENSG00000083168#ENST00000265713#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD, PHD_$#ENSP00000430606#ENSG00000083168#ENST00000485568#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD, PHD_$#ENSP00000399638#ENSG00000083168#ENST00000418721#Other#Acetyltransf_7, MOZ_SAS$#ENSP00000396699#ENSG00000083168#ENST00000426524#Other#	FALSE
2130	ENSG00000156650	KAT6B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Co-factor. Could possibly bind to DNA, as a helix- turn-helix DNA-binding motif is present within its MYST-type HAT domain.	IPR001965;IPR002717;IPR005818;IPR011011;IPR016181;IPR019787	23522	lysine acetyltransferase 6B [Source:HGNC Symbol;Acc:HGNC:17582]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	Yes	None	$#ENSP00000287239#ENSG00000156650#ENST00000287239#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD$#ENSP00000361796#ENSG00000156650#ENST00000372711#Other#Acetyltransf_7, Linker_histone, MOZ_SAS, PHD	FALSE
2131	ENSG00000103510	KAT8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBDs, no evidence of TF activity - looks like a chromatin protein. Included only because it has an x in Vaquerizas 2009.	IPR000953;IPR002717;IPR016181;IPR016197;IPR025995;	84148	lysine acetyltransferase 8 [Source:HGNC Symbol;Acc:HGNC:17933]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Yimeng Yin	Yes	None	$#ENSP00000219797#ENSG00000103510#ENST00000219797#Other#Acetyltransf_7, MOZ_SAS, Myosin_head, Tudor-knot$#ENSP00000406037#ENSG00000103510#ENST00000448516#Other#Acetyltransf_7, MOZ_SAS, Myosin_head, Tudor-knot$#ENSP00000454592#ENSG00000103510#ENST00000537402#Other#Acetyltransf_7, MOZ_SAS$#ENSP00000456933#ENSG00000103510#ENST00000543774#Other#Acetyltransf_7, MOZ_SAS, Myosin_head, Tudor-knot	FALSE
2132	ENSG00000115041	KCNIP3	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	There are multiple papers showing DREAM can bind DNA (PMID: 10078534, PMID: 11108959).	IPR002048;IPR011992;IPR018247	30818	potassium voltage-gated channel interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:15523]	None	not tested	not tested	None	None	No	No	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10078534	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$##ENSG00000115041##Other#	FALSE
2133	ENSG00000004487	KDM1A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Affects transcription by histone modification	IPR002937;IPR007526;IPR009057;IPR017366	23028	lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	$#ENSG00000004487#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019$#ENSG00000004487#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19497860 | IMP - PMID:17805299$#ENSG00000004487#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20833138	$#ENSP00000349049#ENSG00000004487#ENST00000356634#Other#AlaDh_PNT_C, Amino_oxidase, DAO, FAD_binding_2, FA$#ENSP00000383042#ENSG00000004487#ENST00000400181#Other#AlaDh_PNT_C, Amino_oxidase, DAO, FAD_binding_2, FA$#ENSP00000473294#ENSG00000004487#ENST00000494920#Other#Amino_oxidase$#ENSP00000473297#ENSG00000004487#ENST00000465864#Other#Amino_oxidase	FALSE
2134	ENSG00000115548	KDM3A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Its a C6 zinc finger and Jumonji-type protein.  No DBD.	None	55818	Lysine-specific demethylase 3A	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000115548#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000115548##Other#	FALSE
2135	ENSG00000079999	KEAP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000210;IPR006652;IPR011333;IPR011705;IPR013069;IPR017096	9817	kelch like ECH associated protein 1 [Source:HGNC Symbol;Acc:HGNC:23177]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000079999#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:17015834	$#ENSP00000171111#ENSG00000079999#ENST00000171111#Other#BACK, BTB, Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kel$#ENSP00000377245#ENSG00000079999#ENST00000393623#Other#BACK, BTB, Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kel$#ENSP00000468014#ENSG00000079999#ENST00000592478#Other#Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kelch_6$#ENSP00000465024#ENSG00000079999#ENST00000591039#Other#BACK, BTB$#ENSP00000465126#ENSG00000079999#ENST00000591419#Other#BACK, BTB$#ENSP00000468671#ENSG00000079999#ENST00000592055#Other#BACK, BTB	FALSE
2136	ENSG00000122778	KIAA1549	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR024606;	57670	KIAA1549 [Source:HGNC Symbol;Acc:HGNC:22219]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000416040#ENSG00000122778#ENST00000422774#Other#DUF3827$#ENSP00000406661#ENSG00000122778#ENST00000440172#Other#DUF3827	FALSE
2137	ENSG00000130518	KIAA1683	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No evidence to support a DNA binding function	IPR000048;IPR027417	80726	KIAA1683 [Source:HGNC Symbol;Acc:HGNC:29350]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000376213#ENSG00000130518#ENST00000392413#Other#IQ$#ENSP00000470780#ENSG00000130518#ENST00000600328#Other#IQ$#ENSP00000472912#ENSG00000130518#ENST00000600359#Other#IQ	FALSE
2138	ENSG00000165185	KIAA1958	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR021893	158405	KIAA1958 [Source:HGNC Symbol;Acc:HGNC:23427];Uncharacterized protein KIAA1958	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000165185#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000336940#ENSG00000165185#ENST00000337530#Other#DUF3504$#ENSP00000440504#ENSG00000165185#ENST00000536272#Other#DUF3504$#ENSP00000363362#ENSG00000165185#ENST00000374244#Other#DUF3504	FALSE
2139	ENSG00000157404	KIT	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001245;IPR001824;IPR003598;IPR003599;IPR007110;IPR008266;IPR011009;IPR013151;IPR016243;IPR017441;	3815	KIT proto-oncogene receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342];Mast/stem cell growth	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000157404#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:21135090	$#ENSP00000288135#ENSG00000157404#ENST00000288135#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Pkinase, Pkinase_Ty$#ENSP00000390987#ENSG00000157404#ENST00000412167#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Pkinase, Pkinase_Ty	FALSE
2140	ENSG00000184445	KNTC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Rod_C domain localizes to kinetochores but has not been shown to be DNA-binding	IPR017986;IPR019527	9735	kinetochore associated 1 [Source:HGNC Symbol;Acc:HGNC:17255]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000328236#ENSG00000184445#ENST00000333479#Other#Rod_C$#ENSP00000408760#ENSG00000184445#ENST00000436959#Other#MRP-S22, Rod_C$#ENSP00000397992#ENSG00000184445#ENST00000450485#Other#Rod_C$#ENSP00000437344#ENSG00000184445#ENST00000534995#Other#MRP-S22, Rod_C	FALSE
2141	ENSG00000133703	KRAS	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	3845	GTPase KRas	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000133703#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000133703##Other#	FALSE
2142	ENSG00000240747	KRBOX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	KRAB domain only - no DBD or evidence for independent DNA binding	IPR001909	100506243	KRAB box domain containing 1 [Source:HGNC Symbol;Acc:HGNC:38708]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000240747#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000373254#ENSG00000240747#ENST00000383748#Other#KRAB$#ENSP00000388094#ENSG00000240747#ENST00000418176#Other#KRAB$#ENSP00000413859#ENSG00000240747#ENST00000426937#Other#KRAB	FALSE
2143	ENSG00000205869	KRTAP5-1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	387264	keratin associated protein 5-1 [Source:HGNC Symbol;Acc:HGNC:23596]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000371606#ENSG00000205869#ENST00000382171#Other#	FALSE
2144	ENSG00000254997	KRTAP5-9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	3846	keratin associated protein 5-9 [Source:HGNC Symbol;Acc:HGNC:23604]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000431443#ENSG00000254997#ENST00000528743#Other#	FALSE
2145	ENSG00000198083	KRTAP9-9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Keratin-associated protein	IPR002494;	81870	keratin associated protein 9-9 [Source:HGNC Symbol;Acc:HGNC:16773]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000377576#ENSG00000198083#ENST00000394008#Other#Keratin_B2, Keratin_B2_2	FALSE
2146	ENSG00000155506	LARP1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Classic RNA binding protein	IPR006607;IPR006630	23367	La ribonucleoprotein domain family member 1 [Source:HGNC Symbol;Acc:HGNC:29531]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000336721#ENSG00000155506#ENST00000336314#Other#La$#ENSP00000429624#ENSG00000155506#ENST00000518892#Other#$#ENSP00000430169#ENSG00000155506#ENST00000522272#Other#$#ENSP00000429710#ENSG00000155506#ENST00000519931#Other#	FALSE
2147	ENSG00000138709	LARP1B	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR006607;IPR006630	55132	La ribonucleoprotein domain family member 1B [Source:HGNC Symbol;Acc:HGNC:24704]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000377829#ENSG00000138709#ENST00000394288#Other#La$#ENSP00000390395#ENSG00000138709#ENST00000432347#Other#La$#ENSP00000422850#ENSG00000138709#ENST00000512292#Other#La$#ENSP00000424383#ENSG00000138709#ENST00000507377#Other#La	FALSE
2148	ENSG00000161813	LARP4	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Classic RNA binding protein	IPR006630;	113251	La ribonucleoprotein domain family member 4 [Source:HGNC Symbol;Acc:HGNC:24320]	None	Full	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000293618#ENSG00000161813#ENST00000293618#Other#La$#ENSP00000340901#ENSG00000161813#ENST00000347328#Other#La$#ENSP00000381490#ENSG00000161813#ENST00000398473#Other#La$#ENSP00000429077#ENSG00000161813#ENST00000518444#Other#La$#ENSP00000430851#ENSG00000161813#ENST00000518561#Other#La$#ENSP00000429781#ENSG00000161813#ENST00000522085#Other#La$#ENSP00000447408#ENSG00000161813#ENST00000551886#Other#La$#ENSP00000430551#ENSG00000161813#ENST00000523389#Other#$#ENSP00000446540#ENSG00000161813#ENST00000548174#Other#$#ENSP00000448756#ENSG00000161813#ENST00000550260#Other#La$#ENSP00000447397#ENSG00000161813#ENST00000552445#Other#	FALSE
2149	ENSG00000107929	LARP4B	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Classic RNA binding protein	IPR006630;	23185	La ribonucleoprotein domain family member 4B [Source:HGNC Symbol;Acc:HGNC:28987]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000326128#ENSG00000107929#ENST00000316157#Other#La$#ENSP00000403018#ENSG00000107929#ENST00000440895#Other#$#ENSP00000390556#ENSG00000107929#ENST00000412411#Other#	FALSE
2150	ENSG00000166173	LARP6	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Classic RNA binding protein	IPR002344;IPR006630;IPR024642;	55323	La ribonucleoprotein domain family member 6 [Source:HGNC Symbol;Acc:HGNC:24012]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000299213#ENSG00000166173#ENST00000299213#Other#La, SUZ-C$#ENSP00000343869#ENSG00000166173#ENST00000344870#Other#$#ENSP00000453551#ENSG00000166173#ENST00000559140#Other#$#ENSP00000467334#ENSG00000166173#ENST00000559316#Other#	FALSE
2151	ENSG00000174720	LARP7	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Classic RNA binding protein	IPR000504;IPR002344;IPR006630;IPR014886	51574	La ribonucleoprotein domain family member 7 [Source:HGNC Symbol;Acc:HGNC:24912]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000422626#ENSG00000174720#ENST00000509061#Other#La, RRM_3$#ENSP00000344950#ENSG00000174720#ENST00000344442#Other#La, RRM_3$#ENSP00000421541#ENSG00000174720#ENST00000505034#Other#La$#ENSP00000422013#ENSG00000174720#ENST00000513553#Other#RRM_3	FALSE
2152	ENSG00000168961	LGALS9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001079;IPR013320	3965	galectin 9 [Source:HGNC Symbol;Acc:HGNC:6570]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000168961#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:25754930	$#ENSP00000306228#ENSG00000168961#ENST00000302228#Other#Gal-bind_lectin$#ENSP00000378856#ENSG00000168961#ENST00000395473#Other#Gal-bind_lectin$#ENSP00000462382#ENSG00000168961#ENST00000581710#Other#Gal-bind_lectin$#ENSP00000318214#ENSG00000168961#ENST00000313648#Other#Gal-bind_lectin$#ENSP00000462359#ENSG00000168961#ENST00000577392#Other#Gal-bind_lectin$#ENSP00000464581#ENSG00000168961#ENST00000578944#Other#Gal-bind_lectin	FALSE
2153	ENSG00000205213	LGR4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000276;IPR000372;IPR001611;IPR002131;IPR003591;IPR017452;IPR025875;	55366	leucine rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol;Acc:HGNC:13299]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000368516#ENSG00000205213#ENST00000379214#Other#7tm_1, DUF3557, LRRNT, LRR_1, LRR_4, LRR_5, LRR_8,$#ENSP00000374508#ENSG00000205213#ENST00000389858#Other#7tm_1, LRRNT, LRR_1, LRR_4, LRR_5, LRR_8, LRR_9$#ENSP00000431650#ENSG00000205213#ENST00000480977#Other#LRRNT, LRR_1, LRR_4, LRR_5, LRR_8, LRR_9	FALSE
2154	ENSG00000105486	LIG1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA ligase. Binds DNA in the crystal structure (PDB: 1X9N)	None	None	DNA ligase 1	1X9N	not tested	not tested	None	DNA ligase. Binds DNA in the crystal structure (PDB: 1X9N)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2155	ENSG00000005156	LIG3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA ligase. Binds DNA in the crystal structure (PDB: 3L2P)	None	None	DNA ligase 3	3L2P	not tested	not tested	None	DNA ligase. Binds DNA in the crystal structure (PDB: 3L2P)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2156	ENSG00000135363	LMO2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Protein binds to bHLH TFs, which then bind to DNA (PMID: 9707419). Both transfac motifs are suspect - the bHLH motif likely resulted from an indirect interaction.	IPR001781	4005	LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642]	2YPA	not tested	not tested	None	LMO2 does not contact the DNA in the structure but contacts TAL1 and TCF3	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Tim Hughes	No	$#ENSG00000135363#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:16314316$#ENSG00000135363#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:16314316	$#ENSP00000257818#ENSG00000135363#ENST00000257818#Other#LIM$#ENSP00000379175#ENSG00000135363#ENST00000395833#Other#LIM	FALSE
2157	ENSG00000143013	LMO4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001781	8543	LIM domain only 4 [Source:HGNC Symbol;Acc:HGNC:6644]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000143013#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10209267	$#ENSP00000359573#ENSG00000143013#ENST00000370542#Other#LIM$#ENSP00000359575#ENSG00000143013#ENST00000370544#Other#LIM	FALSE
2158	ENSG00000145012	LPP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	znfLIM is probably not a DNA binding domain (PMID: 8506279). The protein has been reported to be coactivator for ETV4 (PMID: 16738319).	IPR001781	4026	LIM domain containing preferred translocation partner in lipoma [Source:HGNC Symbol;Acc:HGNC:6679]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16738319	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$##ENSG00000145012##Other#	FALSE
2159	ENSG00000162337	LRP5	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	None	4041	Low-density lipoprotein receptor-related protein 5	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000162337#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000162337##Other#	FALSE
2160	ENSG00000070018	LRP6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Cell surface receptor that is in the beginning of the WNT signaling cascade. GO annotation has no evidence of DNA-binding activity (PMID: 14739301).	IPR000033;IPR000742;IPR002172;IPR017049;IPR023415	4040	LDL receptor related protein 6 [Source:HGNC Symbol;Acc:HGNC:6698];Low-density lipoprotein receptor-r	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	$#ENSG00000070018#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14739301	$#ENSP00000261349#ENSG00000070018#ENST00000261349#Other#DUF5050, FXa_inhibition, Ldl_recept_a, Ldl_recept_$#ENSP00000442472#ENSG00000070018#ENST00000543091#Other#DUF5050, FXa_inhibition, Ldl_recept_a, Ldl_recept_$#ENSP00000439765#ENSG00000070018#ENST00000535731#Other#Ldl_recept_b, SGL$#ENSP00000443239#ENSG00000070018#ENST00000540527#Other#Ldl_recept_a	FALSE
2161	ENSG00000157193	LRP8	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000033;IPR000152;IPR000742;IPR001881;IPR002172;IPR009030;IPR013032;IPR018097;IPR023415	7804	LDL receptor related protein 8 [Source:HGNC Symbol;Acc:HGNC:6700]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	$#ENSG00000157193#GO:0032793#positive regulation of CREB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000303634#ENSG00000157193#ENST00000306052#Other#DUF5050, EGF_CA, FXa_inhibition, Ldl_recept_a, Ldl$#ENSP00000346391#ENSG00000157193#ENST00000354412#Other#DUF5050, EGF_CA, FXa_inhibition, Ldl_recept_a, Ldl$#ENSP00000360509#ENSG00000157193#ENST00000371454#Other#DUF5050, EGF_CA, FXa_inhibition, Ldl_recept_a, Ldl$#ENSP00000437009#ENSG00000157193#ENST00000465675#Other#DUF5050, FXa_inhibition, Ldl_recept_b, NHL, SGL, S$#ENSP00000436651#ENSG00000157193#ENST00000475501#Other#EGF, EGF_3, EGF_CA, FXa_inhibition, Ldl_recept_b,	FALSE
2162	ENSG00000124831	LRRFIP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Seems to be included only because GO catalogs positive regulation of NF-kappaB transcription factor activity.  Nothing that would indicate DNA binding.	None	9208	Leucine-rich repeat flightless-interacting protein 1	None	not tested	Yes	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	Yes	$#ENSG00000124831#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000124831##Other#	FALSE
2163	ENSG00000093167	LRRFIP2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Its paralog forms a complex with ETS1 that binds AGCCCCCGGCG sequences based on EMSA and SPR (PMID: 16199883). However, direct DNA binding by LRRFIP2 is not demonstrated, and it seems more likely that it is in the complex through protein-protein interactions.	None	None	Leucine-rich repeat flightless-interacting protein 2	None	not tested	not tested	None	Its paralog forms a complex with ETS1 that binds AGCCCCCGGCG sequences based on EMSA and SPR (PMID: 16199883). However, direct DNA binding by LRRFIP2 is not demonstrated, and it seems more likely that it is in the complex through protein-protein interactions.	No	No	No	No	New proteins added after initial stage	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
2164	ENSG00000105699	LSR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Cell plasma membrane resident protein that functions in cell-cell junctions (PMID: 25753034)	IPR003599;IPR007110;IPR008664	51599	lipolysis stimulated lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:29572]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$##ENSG00000105699##Other#	FALSE
2165	ENSG00000012223	LTF	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001156;IPR016357;IPR018195;IPR030684	4057	lactotransferrin [Source:HGNC Symbol;Acc:HGNC:6720]	None	not tested	not tested	None	None	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Matt Weirauch	No	$#ENSG00000012223#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:20345905	$#ENSP00000231751#ENSG00000012223#ENST00000231751#Other#Phosphonate-bd, Transferrin$#ENSP00000405546#ENSG00000012223#ENST00000417439#Other#Phosphonate-bd, Transferrin$#ENSP00000405719#ENSG00000012223#ENST00000426532#Other#Phosphonate-bd, Transferrin$#ENSP00000397427#ENSG00000012223#ENST00000443496#Other#Phosphonate-bd, Transferrin	FALSE
2166	ENSG00000198862	LTN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001841;IPR011016;IPR016024;	26046	listerin E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:13082]	None	DBD	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000354977#ENSG00000198862#ENST00000361371#Other#FANCL_C, RINGv, zf-ANAPC11, zf-RING_2, zf-rbx1$#ENSP00000373846#ENSG00000198862#ENST00000389194#Other#FANCL_C, RINGv, zf-ANAPC11, zf-RING_2, zf-rbx1$#ENSP00000373847#ENSG00000198862#ENST00000389195#Other#$#ENSP00000478783#ENSG00000198862#ENST00000614971#Other#FANCL_C, RINGv, zf-ANAPC11, zf-RING_2, zf-rbx1	FALSE
2167	ENSG00000163818	LZTFL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Lactotransferrin - major iron-binding protein in milk.  Two papers from the 1990s (PMID: 7854459; PMID: 1037119) demonstrate strong DNA binding.	None	54585	leucine zipper transcription factor like 1 [Source:HGNC Symbol;Acc:HGNC:6741]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11352561	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000163818##Other#	FALSE
2168	ENSG00000099949	LZTR1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000210;IPR006652;IPR011333;IPR013069	8216	leucine-zipper-like transcription regulator 1 [Source:HGNC Symbol;Acc:HGNC:6742]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	$#ENSG00000099949#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7633402	$#ENSP00000215739#ENSG00000099949#ENST00000215739#Other#BACK, BTB, Kelch_1, Kelch_2, Kelch_3, Kelch_4, Kel$#ENSP00000397252#ENSG00000099949#ENST00000415817#Other#BTB	FALSE
2169	ENSG00000061337	LZTS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contain a bZIP domain.  (PMID: 10097140) does not examine TF activity or DNA binding - GO needs to be corrected.	IPR033293	11178	leucine zipper, putative tumor suppressor 1 [Source:HGNC Symbol;Acc:HGNC:13861]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000061337#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10097140	$#ENSP00000265801#ENSG00000061337#ENST00000265801#Other#Fez1$#ENSP00000429263#ENSG00000061337#ENST00000522290#Other#Fez1$#ENSP00000479534#ENSG00000061337#ENST00000616228#Other#$#ENSP00000370981#ENSG00000061337#ENST00000381569#Other#Fez1	FALSE
2170	ENSG00000183742	MACC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR011511;	346389	metastasis associated in colon cancer 1 [Source:HGNC Symbol;Acc:HGNC:30215]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000328410#ENSG00000183742#ENST00000332878#Other#Death, SH3_2, ZU5$#ENSP00000383185#ENSG00000183742#ENST00000400331#Other#Death, SH3_2, ZU5$#ENSP00000466864#ENSG00000183742#ENST00000589011#Other#Death, SH3_2, ZU5	FALSE
2171	ENSG00000127603	MACF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because Vasquerizas 2009 includes it with an x.  No DBD and no other data to support being a TF.	IPR001101;IPR001589;IPR001715;IPR002017;IPR002048;IPR003108;IPR011992;IPR018159;IPR018247;	643314	microtubule-actin crosslinking factor 1 [Source:HGNC Symbol;Acc:HGNC:13664]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Tim Hughes	No	None	$#ENSP00000434859#ENSG00000127603#ENST00000484793#Other#$#ENSP00000473615#ENSG00000127603#ENST00000602421#Other#$#ENSP00000435892#ENSG00000127603#ENST00000494012#Other#CH$#ENSP00000431179#ENSG00000127603#ENST00000530275#Other#	FALSE
2172	ENSG00000116670	MAD2L2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Likely to be a DNA-binding protein that operates on DNA-repair (PMID: 25799990)	IPR003511	10459	MAD2 mitotic arrest deficient-like 2 (yeast) [Source:HGNC Symbol;Acc:HGNC:6764]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000116670#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19443654	$#ENSP00000365882#ENSG00000116670#ENST00000376692#Other#HORMA$#ENSP00000235310#ENSG00000116670#ENST00000235310#Other#HORMA$#ENSP00000365855#ENSG00000116670#ENST00000376667#Other#HORMA$#ENSP00000400982#ENSG00000116670#ENST00000456915#Other#HORMA$#ENSP00000365857#ENSG00000116670#ENST00000376669#Other#HORMA$#ENSP00000365860#ENSG00000116670#ENST00000376672#Other#HORMA$#ENSP00000411807#ENSG00000116670#ENST00000445656#Other#HORMA	FALSE
2173	ENSG00000172175	MALT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that operates upstream of NFKB in a signaling cascade (PMID: 18223652)	IPR001309;IPR003598;IPR003599;IPR007110;IPR011029;IPR011600	10892	MALT1 paracaspase [Source:HGNC Symbol;Acc:HGNC:6819];Mucosa-associated lymphoid tissue lymphoma tran	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000172175#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:18223652	$#ENSP00000304161#ENSG00000172175#ENST00000345724#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Izumo-Ig, Peptidase$#ENSP00000319279#ENSG00000172175#ENST00000348428#Other#I-set, Ig_2, Ig_3, Ig_4, Ig_5, Izumo-Ig, Peptidase$#ENSP00000467222#ENSG00000172175#ENST00000591792#Other#I-set, Ig_2, Ig_3, Ig_5, V-set, ig	FALSE
2174	ENSG00000161021	MAML1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	MAML1 does not contact the DNA in the structure (PDB: 2F8X), but contacts RBPJ, which in turn binds DNA	IPR019082	9794	mastermind like transcriptional coactivator 1 [Source:HGNC Symbol;Acc:HGNC:13632]	2F8X	not tested	Yes	None	MAML1 does not contact the DNA in the structure, but contacts RBPJ that in turn binds DNA;Putative TFs that are justr in the TF-CAT	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:16530044	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$##ENSG00000161021##Other#	FALSE
2175	ENSG00000196782	MAML3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019082	55534	Mastermind like transcriptional coactivator 3 [Source:HGNC Symbol;Acc:HGNC:16272]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12370315	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000421180#ENSG00000196782#ENST00000509479#Other#MamL-1$#ENSP00000422783#ENSG00000196782#ENST00000502696#Other#$#ENSP00000381913#ENSG00000196782#ENST00000398940#Other#	FALSE
2176	ENSG00000137764	MAP2K5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase that operates upstream in the signaling cascade that leads to NFKB	IPR000270;IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	5607	mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6845]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000137764#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - PMID:20551324	$#ENSP00000178640#ENSG00000137764#ENST00000178640#Other#Kinase-like, PB1, Pkinase, Pkinase_Tyr$#ENSP00000378859#ENSG00000137764#ENST00000395476#Other#Kinase-like, PB1, Pkinase, Pkinase_Tyr$#ENSP00000342101#ENSG00000137764#ENST00000340972#Other#Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000346493#ENSG00000137764#ENST00000354498#Other#Kinase-like, PB1, Pkinase, Pkinase_Tyr$#ENSP00000390196#ENSG00000137764#ENST00000439036#Other#$#ENSP00000483771#ENSG00000137764#ENST00000557869#Other#	FALSE
2177	ENSG00000130758	MAP3K10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001245;IPR001452;IPR002290;IPR008271;IPR011009;IPR016231;IPR017441	4294	mitogen-activated protein kinase kinase kinase 10 [Source:HGNC Symbol;Acc:HGNC:6849]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000130758#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19801649	$#ENSP00000253055#ENSG00000130758#ENST00000253055#Other#Pkinase, Pkinase_Tyr, SH3_1, SH3_2, SH3_9	FALSE
2178	ENSG00000073803	MAP3K13	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR017419;IPR027258	9175	mitogen-activated protein kinase kinase kinase 13 [Source:HGNC Symbol;Acc:HGNC:6852]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	$#ENSG00000073803#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12492477	$#ENSP00000265026#ENSG00000073803#ENST00000265026#Other#Pkinase, Pkinase_Tyr$#ENSP00000399910#ENSG00000073803#ENST00000424227#Other#Pkinase, Pkinase_Tyr$#ENSP00000392223#ENSG00000073803#ENST00000448876#Other#$#ENSP00000415712#ENSG00000073803#ENST00000420577#Other#Pkinase, Pkinase_Tyr$#ENSP00000390323#ENSG00000073803#ENST00000438798#Other#$#ENSP00000409325#ENSG00000073803#ENST00000443863#Other#Pkinase, Pkinase_Tyr$#ENSP00000411483#ENSG00000073803#ENST00000446828#Other#Pkinase, Pkinase_Tyr$#ENSP00000389495#ENSG00000073803#ENST00000447637#Other#$#ENSP00000412037#ENSG00000073803#ENST00000454237#Other#	FALSE
2179	ENSG00000135341	MAP3K7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a kinase	IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR017421;IPR017441	6885	mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000135341#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000358331#ENSG00000135341#ENST00000369325#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000358333#ENSG00000135341#ENST00000369327#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000358335#ENSG00000135341#ENST00000369329#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000358338#ENSG00000135341#ENST00000369332#Other#APH, Pkinase, Pkinase_Tyr	FALSE
2180	ENSG00000100030	MAPK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	MAP kinase; protein array paper evidence is not strong	IPR000719;IPR002290;IPR003527;IPR008271;IPR008349;IPR011009;IPR017441	5594	mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000100030#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000215832#ENSG00000100030#ENST00000215832#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000381803#ENSG00000100030#ENST00000398822#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000440842#ENSG00000100030#ENST00000544786#Other#APH, Pkinase, Pkinase_Tyr	FALSE
2181	ENSG00000109339	MAPK10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a kinase	IPR000719;IPR002290;IPR003527;IPR008271;IPR008351;IPR011009	5602	mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000109339#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000352157#ENSG00000109339#ENST00000359221#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000355297#ENSG00000109339#ENST00000361569#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000378586#ENSG00000109339#ENST00000395157#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000378589#ENSG00000109339#ENST00000395160#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000378598#ENSG00000109339#ENST00000395169#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000414469#ENSG00000109339#ENST00000449047#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000378595#ENSG00000109339#ENST00000395166#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000424154#ENSG00000109339#ENST00000515400#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000420987#ENSG00000109339#ENST00000513186#Other#	FALSE
2182	ENSG00000185386	MAPK11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR003527;IPR008352;IPR011009;IPR017441	5600	mitogen-activated protein kinase 11 [Source:HGNC Symbol;Acc:HGNC:6873]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000185386#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000333685#ENSG00000185386#ENST00000330651#Other#APH, Cas_CT1975, Kdo, Pkinase, Pkinase_Tyr, RIO1	FALSE
2183	ENSG00000112062	MAPK14	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Well characterized MAPK.  Included because it as a regulator of several TFs and GO captures this.	IPR000719;IPR002290;IPR003527;IPR008352;IPR011009;IPR017441	1432	mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876]	None	not tested	not tested	None	None	No	No	Probably Not a TF - No evidence that it is a TF__TF PPI_PMIDS:9069290;9858528	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000112062#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000229794#ENSG00000112062#ENST00000229794#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000229795#ENSG00000112062#ENST00000229795#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000308669#ENSG00000112062#ENST00000310795#Other#APH, Kdo, Pkinase, Pkinase_Tyr$#ENSP00000419837#ENSG00000112062#ENST00000468133#Other#Pkinase, Pkinase_Tyr	FALSE
2184	ENSG00000102882	MAPK3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR003527;IPR008271;IPR008349;IPR011009;IPR017441	5595	mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877]	None	not tested	not tested	None	None	No	No	Probably Not a TF - No evidence that it is a TF__TF PPI_PMIDS:7889942;8657129	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000102882#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000263025#ENSG00000102882#ENST00000263025#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000378625#ENSG00000102882#ENST00000395199#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000378628#ENSG00000102882#ENST00000395202#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000432742#ENSG00000102882#ENST00000484663#Other#APH, Pkinase, Pkinase_Tyr$#ENSP00000378626#ENSG00000102882#ENST00000395200#Other#Pkinase, Pkinase_Tyr	FALSE
2185	ENSG00000107643	MAPK8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR003527;IPR008271;IPR008351;IPR011009	5599	mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000107643#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000353483#ENSG00000107643#ENST00000360332#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363291#ENSG00000107643#ENST00000374176#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363294#ENSG00000107643#ENST00000374179#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363297#ENSG00000107643#ENST00000374182#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000378974#ENSG00000107643#ENST00000395611#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000363289#ENSG00000107643#ENST00000374174#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000387936#ENSG00000107643#ENST00000432379#Other#Pkinase, Pkinase_Tyr	FALSE
2186	ENSG00000050748	MAPK9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR003527;IPR008271;IPR008351;IPR011009	5601	mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000050748#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - Reactome:R-HSA-450341	$#ENSP00000380262#ENSG00000050748#ENST00000397072#Other#$#ENSP00000443149#ENSG00000050748#ENST00000539014#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1$#ENSP00000389338#ENSG00000050748#ENST00000455781#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr, RIO1	FALSE
2187	ENSG00000015479	MATR3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	An RBP that recognizes MAUCUUR-site based on Ray et al 2013 (PMID: 23846655)	IPR000504;IPR000690;IPR003604;	9782	matrin 3 [Source:HGNC Symbol;Acc:HGNC:6912]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000378284#ENSG00000015479#ENST00000394805#Other#$#ENSP00000423587#ENSG00000015479#ENST00000503811#Other#$#ENSP00000425167#ENSG00000015479#ENST00000511378#Other#$#ENSP00000424646#ENSG00000015479#ENST00000513678#Other#$#ENSP00000422590#ENSG00000015479#ENST00000503340#Other#$#ENSP00000422700#ENSG00000015479#ENST00000504311#Other#$#ENSP00000425150#ENSG00000015479#ENST00000512876#Other#	FALSE
2188	ENSG00000088888	MAVS	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates upstream in the signaling cascade that activates innate immunity response for viruses through NFLB and IRF3 TFs	IPR026148;IPR031964	57506	mitochondrial antiviral signaling protein [Source:HGNC Symbol;Acc:HGNC:29233]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000088888#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16127453	$#ENSP00000413749#ENSG00000088888#ENST00000416600#Other#$#ENSP00000401980#ENSG00000088888#ENST00000428216#Other#CARD_2	FALSE
2189	ENSG00000164430	MB21D1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA with backbone contacts and one minor groove inserting Arginine in the crystal structure (PDB: 4LEY)	None	None	Mab-21 domain containing 1	4LEY	not tested	not tested	None	Binds DNA with backbone contacts and one minor groove inserting Arginine in the crystal structure (PDB: 4LEY)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2190	ENSG00000012174	MBTPS2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GO annotation has no evidence of DNA-binding activity, only modulation of TF activity (PMID: 11163209)	IPR001193;IPR001478;IPR008915	51360	membrane bound transcription factor peptidase, site 2 [Source:HGNC Symbol;Acc:HGNC:15455]	None	not tested	Yes	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000012174#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IGI - PMID:11163209	$#ENSP00000368796#ENSG00000012174#ENST00000365779#Other#DUF4667, PDZ_2, Peptidase_M50$#ENSP00000368798#ENSG00000012174#ENST00000379484#Other#DUF4667, PDZ_2, Peptidase_M50	FALSE
2191	ENSG00000112559	MDFI	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	MDF1 is a co-repressor that inhibits DNA-binding (PMID: 8797820)	IPR026134	4188	MyoD family inhibitor [Source:HGNC Symbol;Acc:HGNC:6967]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8797820	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$##ENSG00000112559##Other#	FALSE
2192	ENSG00000135679	MDM2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR001841;IPR001876;IPR003121;IPR016495;IPR028340	4193	MDM2 proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6973]	None	not tested	Yes	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9271120	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	None	$##ENSG00000135679##Other#	FALSE
2193	ENSG00000198625	MDM4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein binds to, and inhibits, p53 (PMID: 9226370)	IPR001841;IPR001876;IPR003121;IPR015458;IPR016495	4194	MDM4, p53 regulator [Source:HGNC Symbol;Acc:HGNC:6974]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9226370	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$##ENSG00000198625##Other#	FALSE
2194	ENSG00000125686	MED1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is a component of Mediator.	IPR019680	5469	mediator complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:9234];Mediator of RNA polymerase II transcri	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10037764	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	No	$#ENSG00000125686#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000300651#ENSG00000125686#ENST00000300651#Other#Med1$#ENSP00000377828#ENSG00000125686#ENST00000394287#Other#Med1	FALSE
2195	ENSG00000184634	MED12	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019035;IPR021989;IPR021990	9968	mediator complex subunit 12 [Source:HGNC Symbol;Acc:HGNC:11957]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:12612078	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$##ENSG00000184634##Other#	FALSE
2196	ENSG00000108510	MED13	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	9969	Mediator of RNA polymerase II transcription subunit 13	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000108510#GO:1904168#negative regulation of thyroid hormone receptor activity#IEA - GO_REF:0000019	$##ENSG00000108510##Other#	FALSE
2197	ENSG00000123066	MED13L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR009401;IPR021643	23389	mediator complex subunit 13 like [Source:HGNC Symbol;Acc:HGNC:22962]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$##ENSG00000123066##Other#	FALSE
2198	ENSG00000180182	MED14	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR013947	9282	mediator complex subunit 14 [Source:HGNC Symbol;Acc:HGNC:2370]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9989412	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000180182##Other#	FALSE
2199	ENSG00000099917	MED15	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019087	51586	mediator complex subunit 15 [Source:HGNC Symbol;Acc:HGNC:14248]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:12167862	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$##ENSG00000099917##Other#	FALSE
2200	ENSG00000175221	MED16	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is a component of Mediator.	IPR001680;IPR017986;IPR021665	10025	mediator complex subunit 16 [Source:HGNC Symbol;Acc:HGNC:17556]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000175221##Other#	FALSE
2201	ENSG00000042429	MED17	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR019313	9440	mediator complex subunit 17 [Source:HGNC Symbol;Acc:HGNC:2375]	4V1O	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9989412	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000042429##Other#	FALSE
2202	ENSG00000152944	MED21	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure of the yeast mediator complex (PDB: 5SVA)	IPR021384	9412	mediator complex subunit 21 [Source:HGNC Symbol;Acc:HGNC:11473]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_Co-activation_PMIDS:8598913;9159119	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$##ENSG00000152944##Other#	FALSE
2203	ENSG00000112282	MED23	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR021629	9439	mediator complex subunit 23 [Source:HGNC Symbol;Acc:HGNC:2372]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9989412	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$##ENSG00000112282##Other#	FALSE
2204	ENSG00000008838	MED24	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR021429	102466757	mediator complex subunit 24 [Source:HGNC Symbol;Acc:HGNC:22963]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9637681;10406464;12093747	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$##ENSG00000008838##Other#	FALSE
2205	ENSG00000133997	MED6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not bind anywhere near DNA on crystal structure (PDB: 4V1O)	IPR007018;IPR016820	10001	mediator complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:19970]	4V1O	not tested	not tested	None	Structure is for yeast mediator complex	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding__PMIDS:0;9234719;9671455	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$##ENSG00000133997##Other#	FALSE
2206	ENSG00000133895	MEN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Interacts with NFKB1 (PMID: 11526476), JUN, JUND, and ELK1 and represses their activities with a mechanism that is at least for JUN and JUND dependent on their phosphorylation	IPR007747	4221	menin 1 [Source:HGNC Symbol;Acc:HGNC:7010]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000133895#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11526476, PMID:12226747	$#ENSP00000308975#ENSG00000133895#ENST00000312049#Other#Menin$#ENSP00000366538#ENSG00000133895#ENST00000377321#Other#Menin$#ENSP00000388016#ENSG00000133895#ENST00000424912#Other#Menin$#ENSP00000402752#ENSG00000133895#ENST00000429702#Other#Menin$#ENSP00000366530#ENSG00000133895#ENST00000377313#Other#Menin$#ENSP00000411218#ENSG00000133895#ENST00000413626#Other#Menin	FALSE
2207	ENSG00000105976	MET	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Its a cell surface receptor and kinase - included only because Vasquerizas 2009 included it with an x.	IPR000719;IPR001245;IPR001627;IPR002165;IPR002909;IPR008266;IPR011009;IPR014756;IPR016201;IPR016244;IPR017441;	4233	MET proto-oncogene, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	No	None	$#ENSP00000317272#ENSG00000105976#ENST00000318493#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000380860#ENSG00000105976#ENST00000397752#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000410980#ENSG00000105976#ENST00000436117#Other#PSI, Sema, TIG$#ENSP00000413857#ENSG00000105976#ENST00000456159#Other#Sema$#ENSP00000398776#ENSG00000105976#ENST00000422097#Other#TIG	FALSE
2208	ENSG00000170430	MGMT	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	O6-Alklyguanine-DNA alkyltransferase (AGT) is an important DNA repair protein that protects cells from mutagenesis and toxicity arising from alkylating agents (PMID: 15964013); structure (PDB: 1YFH) is with cytosine alkylated DNA	IPR001497;IPR008332;IPR014048;	4255	O-6-methylguanine-DNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:7059]	1YFH	not tested	not tested	None	Pmid: 15964013 O6-Alklyguanine-DNA alkyltransferase (AGT) is an important DNA repair protein that protects cells from mutagenesis and toxicity arising from alkylating agents	x	No	No	No	1a1, Direct HQ evidence	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000302111#ENSG00000170430#ENST00000306010#Other#DNA_binding_1, Methyltransf_1N	FALSE
2209	ENSG00000080561	MID2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GO citation (PMID: 23077300) has no evidence of DNA-binding activity	IPR000315;IPR001841;IPR001870;IPR003649;IPR003877;IPR003879;IPR003961;IPR013320;IPR017903;IPR017907	11043	midline 2 [Source:HGNC Symbol;Acc:HGNC:7096];Probable E3 ubiquitin-protein ligase MID2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000080561#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000080561#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300	$#ENSP00000262843#ENSG00000080561#ENST00000262843#Other#PRY, SPRY, fn3, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf$#ENSP00000413976#ENSG00000080561#ENST00000443968#Other#PRY, SPRY, fn3, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf$#ENSP00000410730#ENSG00000080561#ENST00000451923#Other#CEBP_ZZ, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_	FALSE
2210	ENSG00000141503	MINK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001180;IPR002290;IPR008271;IPR011009;IPR017441	50488	misshapen like kinase 1 [Source:HGNC Symbol;Acc:HGNC:17565]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000269296#ENSG00000141503#ENST00000347992#Other#CNH, Pkinase, Pkinase_Tyr$#ENSP00000347427#ENSG00000141503#ENST00000355280#Other#CNH, Pkinase, Pkinase_Tyr$#ENSP00000406487#ENSG00000141503#ENST00000453408#Other#CNH, Pkinase, Pkinase_Tyr$#ENSP00000459102#ENSG00000141503#ENST00000576037#Other#CNH	FALSE
2211	ENSG00000196588	MKL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-factor	None	57591	MKL/myocardin-like protein 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000196588#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000196588##Other#	FALSE
2212	ENSG00000186260	MKL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003034;IPR004018	57496	MKL1/myocardin like 2 [Source:HGNC Symbol;Acc:HGNC:29819]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12944485;17363709	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$##ENSG00000186260##Other#	FALSE
2213	ENSG00000179455	MKRN3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely E3 ubiquitin ligase. Contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs	IPR000571;IPR001841;IPR017907;IPR018957	7681	makorin ring finger protein 3 [Source:HGNC Symbol;Acc:HGNC:7114]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000456779#ENSG00000179455#ENST00000568252#Other#$#ENSP00000455368#ENSG00000179455#ENST00000564592#Other#$#ENSP00000313881#ENSG00000179455#ENST00000314520#Other#MKRN1_C, zf-ANAPC11, zf-C3HC4, zf-C3HC4_4, zf-RING	FALSE
2214	ENSG00000130382	MLLT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	X-ray structure indicates histone binding (PDB: 4TMP)	IPR005033;	4298	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 [Source:HGNC Symbol;Acc:HGNC:7134]	None	DBD	not tested	None	None	b	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:15096481	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000252674#ENSG00000130382#ENST00000252674#Other#YEATS	FALSE
2215	ENSG00000078403	MLLT10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	No evidence showing MLLT10 can bind to DNA in a sequence-specific manner (PMID: 7888665)	IPR001965;IPR011011;IPR019786;IPR019787	8028	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [Source:HGNC Symbol;Acc:HGNC:16063]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000078403#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7888665	$#ENSP00000307411#ENSG00000078403#ENST00000307729#Other#PHD, PHD_2, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000366258#ENSG00000078403#ENST00000377059#Other#PHD, PHD_2, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000366272#ENSG00000078403#ENST00000377072#Other#PHD, PHD_2, zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000366295#ENSG00000078403#ENST00000377091#Other#PHD, PHD_2$#ENSP00000397800#ENSG00000078403#ENST00000430455#Other#PHD, PHD_2$#ENSP00000484335#ENSG00000078403#ENST00000621220#Other#PHD, PHD_2$#ENSP00000366304#ENSG00000078403#ENST00000377100#Other#PHD, PHD_2$#ENSP00000399883#ENSG00000078403#ENST00000420525#Other#	FALSE
2216	ENSG00000213190	MLLT11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	10962	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [Source:HGNC Symbol;Acc:HGNC:16997]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Other_PMIDS:15530661	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000213190##Other#	FALSE
2217	ENSG00000171843	MLLT3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcription elongation factor [PMID: 20159561; PMID: 20471948]	IPR005033;	4300	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 [Source:HGNC Symbol;Acc:HGNC:7136]	None	DBD	not tested	None	None	b	No	TF Gene_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Co-activation_PMIDS:12776190;16636056	No	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000369695#ENSG00000171843#ENST00000380338#Other#YEATS$#ENSP00000485996#ENSG00000171843#ENST00000630269#Other#YEATS$#ENSP00000369678#ENSG00000171843#ENST00000380321#Other#BET$#ENSP00000486193#ENSG00000171843#ENST00000629733#Other#	FALSE
2218	ENSG00000275023	MLLT6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Likely to be a transcriptional cofactor based on presence of PHD domains and (PMID: 15588942)	IPR001965;IPR011011;IPR019786;IPR019787	4302	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 [Source:HGNC Symbol;Acc:HGNC:7138]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15588942	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$##ENSG00000275023##Other#	FALSE
2219	ENSG00000169184	MN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Evidence for DNA binding not strong in (PMID: 12569362)	None	4330	meningioma (disrupted in balanced translocation) 1 [Source:HGNC Symbol;Acc:HGNC:7180]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12569362	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$##ENSG00000169184##Other#	FALSE
2220	ENSG00000020426	MNAT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001841;IPR003903;IPR004575;IPR015877;IPR017907	4331	MNAT1, CDK activating kinase assembly factor [Source:HGNC Symbol;Acc:HGNC:7181]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_Co-activation; TF PPI_PMIDS:10801852	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000020426##Other#	FALSE
2221	ENSG00000103152	MPG	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA error repair enzyme that excises alkylation-damaged purine bases. Binds dsDNA in the crystal structure (PDB: 1BNK)	None	None	N-methylpurine DNA glycosylase	1BNK	not tested	not tested	None	DNA error repair enzyme that excises alkylation-damaged purine bases. Binds dsDNA in the crystal structure (PDB: 1BNK)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2222	ENSG00000086504	MRPL28	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because it has an X in Vaquerizas 2009	None	10573	mitochondrial ribosomal protein L28 [Source:HGNC Symbol;Acc:HGNC:14484]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000199706#ENSG00000086504#ENST00000199706#Other#Ribosomal_L28$#ENSP00000414038#ENSG00000086504#ENST00000429738#Other#$#ENSP00000374326#ENSG00000086504#ENST00000389675#Other#Ribosomal_L28$#ENSP00000390399#ENSG00000086504#ENST00000447696#Other#Ribosomal_L28$#ENSP00000395305#ENSG00000086504#ENST00000450882#Other#Ribosomal_L28	FALSE
2223	ENSG00000148187	MRRF	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR023584;	92399	mitochondrial ribosome recycling factor [Source:HGNC Symbol;Acc:HGNC:7234]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000377850#ENSG00000148187#ENST00000394315#Other#RRF$#ENSP00000297908#ENSG00000148187#ENST00000297908#Other#14-3-3, RRF$#ENSP00000343867#ENSG00000148187#ENST00000344641#Other#RRF$#ENSP00000395072#ENSG00000148187#ENST00000441707#Other#RRF$#ENSP00000362828#ENSG00000148187#ENST00000373723#Other#RRF$#ENSP00000362834#ENSG00000148187#ENST00000373729#Other#14-3-3, RRF	FALSE
2224	ENSG00000095002	MSH2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA that has a base mismatch as a heterodimer with MSH6. Binds DNA in the crystal structure (PDB: 2O8B)	None	None	mutS homolog 2	2O8B	not tested	not tested	None	Binds DNA that has a base mismatch as a heterodimer with MSH6. Binds DNA in the crystal structure (PDB: 2O8B)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2225	ENSG00000113318	MSH3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Involved in mismatch repair - binds dsDNA with indels (PDB: 3THZ) and changes DNA shape	None	None	mutS homolog 3	3THZ	not tested	not tested	None	Involved in mismatch repair - binds dsDNA with indels (PDB: 3THZ) and changes DNA shape	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2226	ENSG00000116062	MSH6	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA that has base mismatches as a heterodimer with MSH2. Binds DNA in the crystal structure (PDB: 2O8B)	None	None	mutS homolog 6	2O8B	not tested	not tested	None	Binds DNA that has base mismatches as a heterodimer with MSH2. Binds DNA in the crystal structure (PDB: 2O8B)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2227	ENSG00000005302	MSL3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 3OA6). Contacts only the backbone and doesnt cause large changes in the DNA shape	None	None	male-specific lethal 3 homolog (Drosophila)	3OA6	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 3OA6). Contacts only the backbone and doesn't cause large changes in the DNA shape	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2228	ENSG00000148450	MSRB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The paper cited by GO (PMID:10375640) called MSRB2  a TF based on amino acid sequence analysis, but did not provide any direct evidence	IPR002579;IPR011057	22921	methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000148450#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10375640	$#ENSP00000365693#ENSG00000148450#ENST00000376510#Other#SelR	FALSE
2229	ENSG00000164078	MST1R	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001245;IPR001627;IPR002909;IPR008266;IPR011009;IPR014756;IPR016201;IPR016244;IPR017441;IPR020635;	4486	macrophage stimulating 1 receptor [Source:HGNC Symbol;Acc:HGNC:7381]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000296474#ENSG00000164078#ENST00000296474#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000481084#ENSG00000164078#ENST00000612032#Other#Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000482827#ENSG00000164078#ENST00000613534#Other#Pkinase, Pkinase_Tyr, Sema$#ENSP00000482642#ENSG00000164078#ENST00000621387#Other#Kinase-like, PSI, Pkinase, Pkinase_Tyr, Sema, TIG$#ENSP00000414792#ENSG00000164078#ENST00000440292#Other#Pkinase, Pkinase_Tyr	FALSE
2230	ENSG00000147649	MTDH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR031402	92140	metadherin [Source:HGNC Symbol;Acc:HGNC:29608]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	$#ENSG00000147649#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:16452207, PMID:18316612	$#ENSP00000338235#ENSG00000147649#ENST00000336273#Other#LYRIC$#ENSP00000428703#ENSG00000147649#ENST00000522313#Other#LYRIC$#ENSP00000428168#ENSG00000147649#ENST00000519934#Other#LYRIC$#ENSP00000429642#ENSG00000147649#ENST00000521933#Other#LYRIC	FALSE
2231	ENSG00000143033	MTF2	Unknown	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences through PBMs, and crystal structure in complex with DNA	IPR001965;IPR002999;IPR011011;IPR019786;IPR019787;IPR025894	22823	metal response element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:29535]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__DNA Binding_PMIDS:7772254	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	None	$##ENSG00000143033##Other#	FALSE
2232	ENSG00000105887	MTPN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD; no evidence for DNA binding - only included because GO says its a positive regulator of NFkappaB.	IPR002110;IPR020683	136319	myotrophin [Source:HGNC Symbol;Acc:HGNC:15667]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Tim Hughes	No	$#ENSG00000105887#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000376800#ENSG00000105887#ENST00000393085#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000388321#ENSG00000105887#ENST00000435723#Other#Ank_5	FALSE
2233	ENSG00000172732	MUS81	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	MUS81 is a structure-specific endonuclease subunit. It binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with EME1.	None	None	MUS81 structure-specific endonuclease subunit	4P0P	not tested	not tested	None	MUS81 is a structure-specific endonuclease subunit. It binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with EME1.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2234	ENSG00000132382	MYBBP1A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Protein that activates TP53 (PMID: 24375404) and binds to MYB (PMID: 24375404); however, there is no evidence of direct binding to DNA	IPR007015;IPR016024	10514	MYB binding protein 1a [Source:HGNC Symbol;Acc:HGNC:7546]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8302594	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$##ENSG00000132382##Other#	FALSE
2235	ENSG00000214114	MYCBP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	26292	MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7554]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9797456;9797456	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$##ENSG00000214114##Other#	FALSE
2236	ENSG00000172936	MYD88	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates upstream in the signaling cascade (PMID: 22155231)	IPR000157;IPR000488;IPR011029;IPR017281	4615	Myeloid differentiation primary response 88 [Source:HGNC Symbol;Acc:HGNC:7562]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000172936#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:22155231	$#ENSP00000379625#ENSG00000172936#ENST00000396334#Other#Death, TIR, TIR_2$#ENSP00000401399#ENSG00000172936#ENST00000417037#Other#Death, TIR, TIR_2$#ENSP00000391753#ENSG00000172936#ENST00000421516#Other#Death, TIR, TIR_2$#ENSP00000389979#ENSG00000172936#ENST00000424893#Other#Death, TIR, TIR_2$#ENSP00000390565#ENSG00000172936#ENST00000443433#Other#Death$#ENSP00000417848#ENSG00000172936#ENST00000495303#Other#Death	FALSE
2237	ENSG00000104177	MYEF2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single-stranded DNA and can regulate transcription in transfection reporter assays	IPR000504	50804	myelin expression factor 2 [Source:HGNC Symbol;Acc:HGNC:17940]	None	not tested	not tested	None	None	No	No	TF Gene_Single stranded RNA/DNA binding_DNA Binding; Other_PMIDS:7534248;7539003	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000267836#ENSG00000104177#ENST00000267836#Other#$#ENSP00000316950#ENSG00000104177#ENST00000324324#Other#$#ENSP00000478898#ENSG00000104177#ENST00000616409#Other#$#ENSP00000480281#ENSG00000104177#ENST00000620867#Other#	FALSE
2238	ENSG00000141052	MYOCD	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor (PMID: 12640126)	IPR003034;IPR004018	93649	myocardin [Source:HGNC Symbol;Acc:HGNC:16067]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000141052#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22157009$#ENSG00000141052#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IDA - PMID:19578358$#ENSG00000141052#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19098903	$#ENSP00000341835#ENSG00000141052#ENST00000343344#Other#RPEL, SAP$#ENSP00000401678#ENSG00000141052#ENST00000425538#Other#RPEL, SAP$#ENSP00000400148#ENSG00000141052#ENST00000443061#Other#SAP	FALSE
2239	ENSG00000166886	NAB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Well characterized transcriptional co-repressor of e.g. EGR1 (PMID: 12427750)	IPR006988;IPR006989	4665	NGFI-A binding protein 2 [Source:HGNC Symbol;Acc:HGNC:7627]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10734128;12427750	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	None	$##ENSG00000166886##Other#	FALSE
2240	ENSG00000139579	NABP2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 4OWW)	None	None	nucleic acid binding protein 2	4OWW	not tested	not tested	None	Binds single stranded DNA in the structure (PDB: 4OWW)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2241	ENSG00000148411	NACC2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds DNA as a homodimer, recognizing a TGTCRSWWYYGWC consensus based on SELEX experiments (PMID: 22926524)	IPR000210;IPR011333;IPR013069;IPR018379	138151	NACC family member 2 [Source:HGNC Symbol;Acc:HGNC:23846];Nucleus accumbens-associated protein 2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000148411#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:22926524	$#ENSP00000277554#ENSG00000148411#ENST00000277554#Other#BEN, BTB$#ENSP00000360818#ENSG00000148411#ENST00000371753#Other#BEN, BTB	FALSE
2242	ENSG00000266412	NCOA4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR022174	8031	nuclear receptor coactivator 4 [Source:HGNC Symbol;Acc:HGNC:7671]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8643607	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000266412##Other#	FALSE
2243	ENSG00000124160	NCOA5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Known coactivator with no DBD	IPR004154	57727	nuclear receptor coactivator 5 [Source:HGNC Symbol;Acc:HGNC:15909]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11113208	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	No	None	$##ENSG00000124160##Other#	FALSE
2244	ENSG00000198646	NCOA6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a transcriptional co-regulator (PMID: 10681503)	None	23054	nuclear receptor coactivator 6 [Source:HGNC Symbol;Acc:HGNC:15936]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10681503	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000198646##Other#	FALSE
2245	ENSG00000111912	NCOA7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Known co-activator; included only because TF-cat documents this	IPR006571;IPR018392	135112	nuclear receptor coactivator 7 [Source:HGNC Symbol;Acc:HGNC:21081]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11971969	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	None	$##ENSG00000111912##Other#	FALSE
2246	ENSG00000182636	NDN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	4692	Necdin	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	$#ENSG00000182636#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$##ENSG00000182636##Other#	FALSE
2247	ENSG00000124479	NDP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity.  Not DNA binding.	None	4693	Norrin	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	$#ENSG00000124479#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000124479##Other#	FALSE
2248	ENSG00000140398	NEIL1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA glycosylase 1. Binds DNA in the crystal structure (PDB: 5ITR)	None	None	nei like DNA glycosylase 1	5ITR	not tested	not tested	None	DNA glycosylase 1. Binds DNA in the crystal structure (PDB: 5ITR)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2249	ENSG00000235568	NFAM1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development (PMID: 15143214)	IPR003110	150372	NFAT activating protein with ITAM motif 1 [Source:HGNC Symbol;Acc:HGNC:29872]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	$#ENSG00000235568#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:12615919	$#ENSP00000333680#ENSG00000235568#ENST00000329021#Other#	FALSE
2250	ENSG00000230257	NFE4	Unknown	Yes	Known motif	Obligate heteromer	In vivo/Misc source	None	NFE4 does not posess a DBD. It is a member of the SSP complex that regulates B-globin gene expression, and binds DNA as a heteromer with CP2, based on EMSA (PMID: 7828600; PMID: 15273251). A shorter isoform prevents CP2 binding (PMID: 16263792) and is involved in repression. No gel-shift experiments have been performed in the absence of its partner, CP2, thus its likely an obligate heteromer.	None	None	nuclear factor, erythroid 4	None	not tested	not tested	None	None	No	No	No	No	New proteins added after initial stage	None	None	No	None	None	FALSE
2251	ENSG00000100906	NFKBIA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is I kappa B alpha, which interacts with NFkappaB.  No DBD, and evidence indicates that it is not a TF.	IPR002110;IPR020683	4792	NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797]	None	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF__TF PPI_PMIDS:3140380;8717528	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Tim Hughes	Yes	$#ENSG00000100906#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11931770$#ENSG00000100906#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000216797#ENSG00000100906#ENST00000216797#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000450514#ENSG00000100906#ENST00000557389#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000451281#ENSG00000100906#ENST00000553342#Other#$#ENSP00000451257#ENSG00000100906#ENST00000557140#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5	FALSE
2252	ENSG00000104825	NFKBIB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	From (PMID: 12686541), it appears that the ternary complex is stabilized by an interaction with this protein, which suggests that this protein may offer a conducive electrostatic environment rather directly contributing to the binding event.	IPR002110;IPR020683	4793	NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000104825#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000312988#ENSG00000104825#ENST00000313582#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000459728#ENSG00000104825#ENST00000572515#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000458685#ENSG00000104825#ENST00000575359#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000461617#ENSG00000104825#ENST00000576510#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5	FALSE
2253	ENSG00000167604	NFKBID	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	84807	NF-kappa-B inhibitor delta	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	Yes	$#ENSG00000167604#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000167604##Other#	FALSE
2254	ENSG00000204498	NFKBIL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR020683	None	NFKB inhibitor like 1 [Source:HGNC Symbol;Acc:HGNC:7800]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	Yes	None	None	FALSE
2255	ENSG00000144802	NFKBIZ	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002110;IPR020683	64332	NFKB inhibitor zeta [Source:HGNC Symbol;Acc:HGNC:29805]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding; TF PPI; Transactivation_PMIDS:15241416	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	Yes	None	$##ENSG00000144802##Other#	FALSE
2256	ENSG00000170322	NFRKB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Has a winged helix but cannot bind to the NFKB consensus.	IPR025220;	4798	nuclear factor related to kappaB binding protein [Source:HGNC Symbol;Acc:HGNC:7802]	None	not tested	not tested	None	None	other	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$#ENSP00000436926#ENSG00000170322#ENST00000524794#Other#NFRKB_winged$#ENSP00000432520#ENSG00000170322#ENST00000526940#Other#$#ENSP00000431247#ENSG00000170322#ENST00000526884#Other#$#ENSP00000434326#ENSG00000170322#ENST00000529319#Other#	FALSE
2257	ENSG00000120837	NFYB	Unknown	Yes	Known motif	Obligate heteromer	In vivo/Misc source	None	Obligate heterotrimer of NFYA, NFYB, and NFYC	IPR003956;IPR003958;IPR009072;	4801	nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805]	4AWL	DBD and Full	not tested	Obligate_Multimer	Obligate heterotrimer	a	Yes	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:12401788	Yes	1a1, Direct HQ evidence	Yimeng Yin	Arttu Jolma	Yes	$#ENSG00000120837#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000240055#ENSG00000120837#ENST00000240055#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-18kDa$#ENSP00000448250#ENSG00000120837#ENST00000551446#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-18kDa$#ENSP00000447486#ENSG00000120837#ENST00000551727#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-18kDa	FALSE
2258	ENSG00000066136	NFYC	Unknown	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	PDB 4AWL is a very tightly intertwined heterotrimeric complex of NFYA, NFYB and NFYC with a plenty of protein-protein interactions. NFYA contains the recognition alpha-helix but there is no point considering any of the components separately as they are definitely complexed even in the solution and all contribute contacts with the DNA backbone.	IPR003958;IPR009072	4802	nuclear transcription factor Y subunit gamma [Source:HGNC Symbol;Acc:HGNC:7806]	4AWL	DBD and Full	not tested	Obligate_Multimer	Obligate heterotrimer	a	Yes	TF Gene_DNA-Binding: sequence-specific__PMIDS:0	Yes	1a1, Direct HQ evidence	Pratyush Das	Tim Hughes	Yes	$#ENSG00000066136#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019$#ENSG00000066136#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10446203, PMID:9332362	$#ENSP00000312617#ENSG00000066136#ENST00000308733#Other#CBFD_NFYB_HMF, Histone$#ENSP00000361738#ENSG00000066136#ENST00000372654#Other#CBFD_NFYB_HMF, Histone$#ENSP00000404427#ENSG00000066136#ENST00000447388#Other#CBFD_NFYB_HMF, Histone$#ENSP00000408867#ENSG00000066136#ENST00000456393#Other#CBFD_NFYB_HMF, Histone$#ENSP00000361736#ENSG00000066136#ENST00000372652#Other#CBFD_NFYB_HMF, Histone$#ENSP00000361737#ENSG00000066136#ENST00000372653#Other#CBFD_NFYB_HMF, Histone$#ENSP00000396620#ENSG00000066136#ENST00000425457#Other#CBFD_NFYB_HMF, Histone$#ENSP00000408315#ENSG00000066136#ENST00000427410#Other#CBFD_NFYB_HMF$#ENSP00000416403#ENSG00000066136#ENST00000414185#Other#	FALSE
2259	ENSG00000186416	NKRF	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds AATTTCCTCTGA based on EMSA (PMID: 11071890) and to AATTCCCTGA based on another EMSA (PMID: 16107696)	IPR000467;IPR001374;IPR014720;	55922	NFKB repressing factor [Source:HGNC Symbol;Acc:HGNC:19374]	None	Full	not tested	None	None	other	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000304803#ENSG00000186416#ENST00000304449#Other#G-patch, G-patch_2, R3H, dsrm$#ENSP00000360582#ENSG00000186416#ENST00000371527#Other#G-patch, G-patch_2, R3H, dsrm$#ENSP00000442308#ENSG00000186416#ENST00000542113#Other#G-patch, G-patch_2, R3H, dsrm	FALSE
2260	ENSG00000167984	NLRC3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003590;IPR007111	197358	NLR family CARD domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29889]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000167984#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15705585	$#ENSP00000352039#ENSG00000167984#ENST00000359128#Other#LRR_4, LRR_6, LRR_8, NACHT$#ENSP00000482302#ENSG00000167984#ENST00000618137#Other#LRR_1, LRR_4, LRR_6, LRR_8$#ENSP00000323897#ENSG00000167984#ENST00000324659#Other#LRR_4, LRR_6, LRR_8, NACHT	FALSE
2261	ENSG00000091106	NLRC4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001315;IPR007111;IPR011029;IPR027417	58484	NLR family CARD domain containing 4 [Source:HGNC Symbol;Acc:HGNC:16412]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	$#ENSG00000091106#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12646168	$#ENSP00000339666#ENSG00000091106#ENST00000342905#Other#CARD$#ENSP00000354159#ENSG00000091106#ENST00000360906#Other#CARD, NACHT$#ENSP00000385428#ENSG00000091106#ENST00000402280#Other#CARD, NACHT$#ENSP00000385090#ENSG00000091106#ENST00000404025#Other#CARD, NACHT	FALSE
2262	ENSG00000140853	NLRC5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein inhibits NFKB activity	IPR001611;IPR003590;IPR006553;IPR007111;IPR025875;IPR027417	84166	NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000140853#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20434986	$#ENSP00000442906#ENSG00000140853#ENST00000538805#Other#LRR_1, LRR_4, LRR_6, LRR_8, NACHT$#ENSP00000440184#ENSG00000140853#ENST00000399221#Other#LRR_6$#ENSP00000441311#ENSG00000140853#ENST00000538059#Other#$#ENSP00000439464#ENSG00000140853#ENST00000544641#Other#	FALSE
2263	ENSG00000142405	NLRP12	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001611;IPR003590;IPR004020;IPR007111;IPR011029;IPR027417;IPR029495	91662	NLR family pyrin domain containing 12 [Source:HGNC Symbol;Acc:HGNC:22938];NACHT, LRR and PYD domains	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000142405#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18230725	$#ENSP00000319377#ENSG00000142405#ENST00000324134#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000341428#ENSG00000142405#ENST00000345770#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375652#ENSG00000142405#ENST00000391772#Other#FISNA, LRR_6, NACHT, PYRIN$#ENSP00000375653#ENSG00000142405#ENST00000391773#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375655#ENSG00000142405#ENST00000391775#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN	FALSE
2264	ENSG00000215174	NLRP2B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR011029	286430	NLR family pyrin domain containing 2B [Source:HGNC Symbol;Acc:HGNC:29887];Pyrin domain-containing pr	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000215174#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:24871464	$#ENSP00000488995#ENSG00000215174#ENST00000434992#Other#PYRIN	FALSE
2265	ENSG00000162711	NLRP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates upstream in the signaling cascade	IPR003590;IPR004020;IPR007111;IPR011029;IPR027417;IPR029495	114548	NLR family pyrin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16400]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000162711#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:14662828$#ENSG00000162711#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19158675	$#ENSP00000337383#ENSG00000162711#ENST00000336119#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000294752#ENSG00000162711#ENST00000348069#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000355452#ENSG00000162711#ENST00000366496#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000355453#ENSG00000162711#ENST00000366497#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375703#ENSG00000162711#ENST00000391827#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN$#ENSP00000375704#ENSG00000162711#ENST00000391828#Other#FISNA, LRR_4, LRR_6, NACHT, PYRIN	FALSE
2266	ENSG00000243678	NME2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds to telomeres (PMID: 22135295). Binds specific sequences by gel-shift, and binding is impacted by a SNP (PMID: 23368879)	IPR001564;IPR023005	None	NME1-NME2 readthrough [Source:HGNC Symbol;Acc:HGNC:33531];Nucleoside diphosphate kinase B	None	not tested	not tested	None	Binds to telomeres (PMID: 22135295). Binds specific sequences by gel-shift, and binding is impacted by a SNP (PMID: 23368879)	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	None	None	FALSE
2267	ENSG00000173145	NOC3L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No evidence to support a DNA binding function	IPR005612;IPR011501;IPR016024;IPR016903	64318	NOC3 like DNA replication regulator [Source:HGNC Symbol;Acc:HGNC:24034]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000360412#ENSG00000173145#ENST00000371361#Other#CBF, DUF2732, NOC3p	FALSE
2268	ENSG00000184967	NOC4L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is associated with ribosome synthesis (PMID: 27798105)	IPR005612;IPR016024	79050	nucleolar complex associated 4 homolog [Source:HGNC Symbol;Acc:HGNC:28461]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000328854#ENSG00000184967#ENST00000330579#Other#CBF$#ENSP00000438255#ENSG00000184967#ENST00000541954#Other#	FALSE
2269	ENSG00000151014	NOCT	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Deadenylase protein that probably regulates genes post-transcriptionally (PMID: 22073225)	IPR005135	25819	nocturnin [Source:HGNC Symbol;Acc:HGNC:14254]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000151014#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10521507	$#ENSP00000280614#ENSG00000151014#ENST00000280614#Other#Exo_endo_phos, Exo_endo_phos_2	FALSE
2270	ENSG00000106100	NOD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	NOD-proteins function in signaling cascades that report bacterial peptidoglycans. They activate kinases that in turn activate NFKB proteins etc. Reviewed in (PMID: 25526305)	IPR001315;IPR003590;IPR007111;IPR011029	10392	nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000106100#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:17054981, PMID:19043560 | TAS - Reactom	$#ENSP00000222823#ENSG00000106100#ENST00000222823#Other#AAA_16, AAA_18, CARD, LRR_4, LRR_6, NACHT$#ENSP00000396046#ENSG00000106100#ENST00000411552#Other#CARD$#ENSP00000399505#ENSG00000106100#ENST00000413433#Other#CARD$#ENSP00000410917#ENSG00000106100#ENST00000419601#Other#$#ENSP00000395551#ENSG00000106100#ENST00000419799#Other#CARD	FALSE
2271	ENSG00000167207	NOD2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001315;IPR001611;IPR003590;IPR007111;IPR011029;IPR027417	64127	nucleotide binding oligomerization domain containing 2 [Source:HGNC Symbol;Acc:HGNC:5331]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000167207#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11385577, PMID:12527755, PMID:21887730	$#ENSP00000431681#ENSG00000167207#ENST00000531674#Other#CARD$#ENSP00000437246#ENSG00000167207#ENST00000534057#Other#LRR_4, LRR_6, LRR_8$#ENSP00000300589#ENSG00000167207#ENST00000300589#Other#AAA_16, AAA_22, AAA_29, CARD, LRR_4, LRR_6, LRR_8,	FALSE
2272	ENSG00000156574	NODAL	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a secreted signaling molecule	IPR001111;IPR001839;IPR017948;IPR029034	4838	nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000156574#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:21116837	$#ENSP00000287139#ENSG00000156574#ENST00000287139#Other#TGF_beta, TGFb_propeptide$#ENSP00000394468#ENSG00000156574#ENST00000414871#Other#TGF_beta, TGFb_propeptide	FALSE
2273	ENSG00000147140	NONO	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RBP with RRM domains	None	4841	non-POU domain containing, octamer-binding [Source:HGNC Symbol;Acc:HGNC:7871]	None	not tested	not tested	None	None	No	No	No	No	2a1, Lower confidence direct evidence	Pratyush Das	Arttu Jolma	Yes	None	$##ENSG00000147140##Other#	FALSE
2274	ENSG00000111641	NOP2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001678;IPR011023;IPR012586;IPR018314;IPR023267;IPR023273;IPR029063	4839	NOP2 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:7867]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$##ENSG00000111641##Other#	FALSE
2275	ENSG00000148400	NOTCH1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	A transmembrane protein that inhibits MEF2C activation (PMID: 10082551). NOTCH1 does not bind DNA in the structure, and is not required for DNA binding, since RBPJ is bound without it in (PDB:4J2X).	IPR000152;IPR000742;IPR000800;IPR001881;IPR002110;IPR008297;IPR009030;IPR010660;IPR011656;IPR013032;IPR018097;	4851	notch 1 [Source:HGNC Symbol;Acc:HGNC:7881]	2F8X	not tested	Yes	None	NOTCH1 does not contact DNA in the structure	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10082551;15991363	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	$#ENSG00000148400#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000148400##Other#	FALSE
2276	ENSG00000134250	NOTCH2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transmembrane receptor protein that operates far upstream in the signaling cascade	IPR000152;IPR000742;IPR000800;IPR001881;IPR002110;IPR008297;IPR009030;IPR010660;IPR011656;IPR013032;IPR018097;	4853	notch 2 [Source:HGNC Symbol;Acc:HGNC:7882]	None	not tested	Yes	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:15134786	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$##ENSG00000134250##Other#	FALSE
2277	ENSG00000074181	NOTCH3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Fragment of NOTCH. Is a coactivator.	IPR000152;IPR000742;IPR000800;IPR001881;IPR002110;IPR008297;IPR009030;IPR010660;IPR011656;IPR013032;IPR018097;	4854	notch 3 [Source:HGNC Symbol;Acc:HGNC:7883]	None	not tested	Yes	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Transactivation_PMIDS:16365048	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$##ENSG00000074181##Other#	FALSE
2278	ENSG00000181163	NPM1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	No evidence for sequence-specific DNA-binding (PMID: 2223875)	IPR024057	4869	nucleophosmin (nucleolar phosphoprotein B23, numatrin) [Source:HGNC Symbol;Acc:HGNC:7910]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding; Single stranded RNA/DNA binding_Non-specific DNA_PMIDS:2223875;16107701	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000181163#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:15087454	$#ENSP00000296930#ENSG00000181163#ENST00000296930#Other#NPM1-C, Nop14, Nucleoplasmin, SDA1$#ENSP00000341168#ENSG00000181163#ENST00000351986#Other#DUF2457, Drc1-Sld2, NPM1-C, Nucleoplasmin, SDA1$#ENSP00000377408#ENSG00000181163#ENST00000393820#Other#Nucleoplasmin, SDA1$#ENSP00000428755#ENSG00000181163#ENST00000517671#Other#NPM1-C, Nop14, Nucleoplasmin, SDA1$#ENSP00000428647#ENSG00000181163#ENST00000523622#Other#Nucleoplasmin	FALSE
2279	ENSG00000169297	NR0B1	Unknown	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR000536;IPR001723;IPR008946;IPR025900	190	nuclear receptor subfamily 0 group B member 1 [Source:HGNC Symbol;Acc:HGNC:7960]	None	not tested	not tested	None	None	a	Yes	TF Gene_DNA-Binding: sequence-specific_TF PPI_PMIDS:16709599;9032275;9384387;10848616;11053406;11427738;9384387;12482977;15155786;15464421;9032275;9384387;9661652;10848616	Yes	2a1, Lower confidence direct evidence	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000169297#GO:0004879#ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity#IDA - PMID:7990953 | NAS - PMID:9384387$#ENSG00000169297#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19651776	$#ENSP00000368253#ENSG00000169297#ENST00000378970#Nuclear Hormone Receptor#Hormone_recep, NR_Repeat$#ENSP00000368246#ENSG00000169297#ENST00000378963#Nuclear Hormone Receptor#Hormone_recep	FALSE
2280	ENSG00000131910	NR0B2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcription cofactor - lacks a conventional DNA binding domain and represses the transcriptional activity of various nuclear receptors (PMID: 14752053)	IPR000536;IPR001723;IPR008946;	8431	nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961]	None	not tested	not tested	None	None	x	No	No	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Laura Campitelli	Yes	$#ENSG00000131910#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:14752053	$#ENSP00000254227#ENSG00000131910#ENST00000254227#Other#Hormone_recep	FALSE
2281	ENSG00000106459	NRF1	Unknown	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR019525;IPR019526	4899	nuclear respiratory factor 1 [Source:HGNC Symbol;Acc:HGNC:7996]	None	DBD and Full	not tested	None	None	other	Yes	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding; Transactivation_PMIDS:9580677	Yes	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	Yes	$#ENSG00000106459#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:19674972 | IMP - PMID:19674972	$#ENSP00000309826#ENSG00000106459#ENST00000311967#NRF#Nrf1_DNA-bind, Nrf1_activ_bdg$#ENSP00000376922#ENSG00000106459#ENST00000393230#NRF#Nrf1_DNA-bind, Nrf1_activ_bdg$#ENSP00000376924#ENSG00000106459#ENST00000393232#NRF#Nrf1_DNA-bind, Nrf1_activ_bdg	FALSE
2282	ENSG00000157168	NRG1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Cell surface receptor - does not have predicted DBDs	IPR000742;IPR002154;IPR003598;IPR003599;IPR007110;IPR013032;IPR013098;IPR018250	3084	neuregulin 1 [Source:HGNC Symbol;Acc:HGNC:7997]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:15494726;7559778;7589796;15494726;12529413;15494726;7816098;12649319;15073182;15494726;15498868	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$##ENSG00000157168##Other#	FALSE
2283	ENSG00000180530	NRIP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor	None	8204	nuclear receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8001]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9774688	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000180530##Other#	FALSE
2284	ENSG00000175352	NRIP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Binds indirectly to DNA through interactions with NHR TFs (PMID: 10860982)	IPR019103;IPR021109	56675	nuclear receptor interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1167]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10860982	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$##ENSG00000175352##Other#	FALSE
2285	ENSG00000123572	NRK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a kinase	IPR000719;IPR001180;IPR002290;IPR008271;IPR011009;IPR017441	203447	Nik related kinase [Source:HGNC Symbol;Acc:HGNC:25391]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$#ENSP00000434830#ENSG00000123572#ENST00000243300#Other#CNH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000438785#ENSG00000123572#ENST00000536164#Other#Pkinase, Pkinase_Tyr$#ENSP00000438148#ENSG00000123572#ENST00000540278#Other#CNH	FALSE
2286	ENSG00000165671	NSD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a histone methyltransferase with H3K36 and H4K20 methylation activities (PMID: 12805229)	IPR000313;IPR001214;IPR001965;IPR003616;IPR006560;IPR011011;IPR019786;IPR019787	64324	nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9628876;12805229	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000165671##Other#	FALSE
2287	ENSG00000198400	NTRK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Membrane bound receptor protein	IPR000483;IPR000719;IPR001245;IPR001611;IPR002011;IPR007110;IPR008266;IPR011009;IPR017441;IPR020461;IPR020635;	4914	neurotrophic receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:8031];High affinity nerve growt	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000198400#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:15488758	$#ENSP00000357179#ENSG00000198400#ENST00000368196#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP$#ENSP00000431418#ENSG00000198400#ENST00000524377#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP$#ENSP00000351486#ENSG00000198400#ENST00000358660#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP$#ENSP00000376120#ENSG00000198400#ENST00000392302#Other#I-set, Ig_2, Ig_3, LRR_8, Pkinase, Pkinase_Tyr, TP	FALSE
2288	ENSG00000069275	NUCKS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a GRP core, which is similar to an AT-hook.  But, the amino acids flanking the core are quite different from an AT-hook. Could non-specifically bind to DNA, but lacks compelling evidence.	None	64710	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000069275#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$##ENSG00000069275##Other#	FALSE
2289	ENSG00000110713	NUP98	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR007230;IPR021967	4928	nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$##ENSG00000110713##Other#	FALSE
2290	ENSG00000114026	OGG1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA error repairing enzyme. Binds DNA in the crystal structure (PDB: 1EBM), presumably without specificity	None	None	8-oxoguanine DNA glycosylase	1EBM	not tested	not tested	None	DNA error repairing enzyme. Binds DNA in the crystal structure (PDB: 1EBM), presumably without specificity	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2291	ENSG00000116329	OPRD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transmembrane protein	IPR000276;IPR000321;IPR001418;IPR017452	4985	opioid receptor delta 1 [Source:HGNC Symbol;Acc:HGNC:8153]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000116329#GO:0032793#positive regulation of CREB transcription factor activity#IC - PMID:24613828	$#ENSP00000234961#ENSG00000116329#ENST00000234961#Other#7TM_GPCR_Srsx, 7TM_GPCR_Srv, 7TM_GPCR_Srx, 7tm_1, $#ENSP00000477970#ENSG00000116329#ENST00000621425#Other#7TM_GPCR_Srsx, 7TM_GPCR_Srx, 7tm_1, 7tm_4	FALSE
2292	ENSG00000182938	OTOP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR004878;IPR007087	347741	otopetrin 3 [Source:HGNC Symbol;Acc:HGNC:19658]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$#ENSP00000328090#ENSG00000182938#ENST00000328801#Other#Otopetrin	FALSE
2293	ENSG00000154124	OTULIN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR023235;IPR023237	90268	OTU deubiquitinase with linear linkage specificity [Source:HGNC Symbol;Acc:HGNC:25118];Ubiquitin thi	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000154124#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:23746843, PMID:24726327, PMID:27559085	$#ENSP00000284274#ENSG00000154124#ENST00000284274#Other#Peptidase_C101, Peptidase_C65$#ENSP00000424966#ENSG00000154124#ENST00000506417#Other#Peptidase_C101	FALSE
2294	ENSG00000170515	PA2G4	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds CGGCAAAAAGG repeats based on EMSA performed with recombinant E.Coli expressed protein (PMID: 1507318)	IPR000994;IPR004545;IPR018349	5036	proliferation-associated 2G4 [Source:HGNC Symbol;Acc:HGNC:8550]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000170515#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:15073182	$#ENSP00000302886#ENSG00000170515#ENST00000303305#Other#Peptidase_M24$#ENSP00000447389#ENSG00000170515#ENST00000551061#Other#Peptidase_M24$#ENSP00000447615#ENSG00000170515#ENST00000553057#Other#Peptidase_M24$#ENSP00000448557#ENSG00000170515#ENST00000552766#Other#Peptidase_M24	FALSE
2295	ENSG00000100836	PABPN1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504	8106	poly(A) binding protein nuclear 1 [Source:HGNC Symbol;Acc:HGNC:8565]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11371506	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$##ENSG00000100836##Other#	FALSE
2296	ENSG00000116288	PARK7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates upstream in the signaling cascade	IPR002818;IPR006287;IPR029062	11315	Parkinsonism associated deglycase [Source:HGNC Symbol;Acc:HGNC:16369]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000116288#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:17015834 | TAS - PMID:22492997$#ENSG00000116288#GO:2000825#positive regulation of androgen receptor activity#IMP - PMID:17510388	$#ENSP00000340278#ENSG00000116288#ENST00000338639#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000418770#ENSG00000116288#ENST00000493678#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000466242#ENSG00000116288#ENST00000377493#Other#DJ-1_PfpI$#ENSP00000366708#ENSG00000116288#ENST00000377488#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000366711#ENSG00000116288#ENST00000377491#Other#DJ-1_PfpI, GATase_3, ThiJ_like$#ENSP00000466756#ENSG00000116288#ENST00000469225#Other#DJ-1_PfpI, GATase_3	FALSE
2297	ENSG00000143799	PARP1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	In vivo/Misc source	None	DNA repair protein that binds dsDNA non-specifically (PMID: 21183686; PMID: 21262234). The Transfac motifs are likely NFAT target sites	IPR001357;IPR001510;IPR004102;IPR008288;IPR008893;IPR012317;IPR012982	142	poly(ADP-ribose) polymerase 1 [Source:HGNC Symbol;Acc:HGNC:270]	2N8A	not tested	not tested	None	Structure has dsDNA with a single strand break, presumably non sequence-specific interaction	No	Yes	TF Gene Candidate_DNA-Binding: non-sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor	No	2a1, Lower confidence direct evidence	Yimeng Yin	Arttu Jolma	No	None	$#ENSP00000355759#ENSG00000143799#ENST00000366794#Other#BRCT, BRCT_2, PADR1, PARP, PARP_reg, WGR, zf-PARP$#ENSP00000355755#ENSG00000143799#ENST00000366790#Other#zf-PARP$#ENSP00000355757#ENSG00000143799#ENST00000366792#Other#zf-PARP$#ENSP00000485852#ENSG00000143799#ENST00000629232#Other#zf-PARP	FALSE
2298	ENSG00000178685	PARP10	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains two RRM domains, so likely an RNA-binding protein. Myc-interacting factor capable of ADP-ribosylating itself and core histones (PMID: 15674325).	IPR012317	84875	poly(ADP-ribose) polymerase family member 10 [Source:HGNC Symbol;Acc:HGNC:25895]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000178685#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:23575687	$#ENSP00000325618#ENSG00000178685#ENST00000313028#Other#PARP$#ENSP00000314320#ENSG00000178685#ENST00000313059#Other#$#ENSP00000434776#ENSG00000178685#ENST00000525773#Other#PARP$#ENSP00000431818#ENSG00000178685#ENST00000528625#Other#$#ENSP00000436301#ENSG00000178685#ENST00000525879#Other#	FALSE
2299	ENSG00000177425	PAWR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that binds to several TFs such as PITX2 (PMID: 19801652) and appears to inactivate them	None	5074	pro-apoptotic WT1 regulator [Source:HGNC Symbol;Acc:HGNC:8614]	None	Full	not tested	None	None	other	No	Probably Not a TF - No evidence that it is a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000328088#ENSG00000177425#ENST00000328827#Other#ATG16, FPP, IncA$#ENSP00000449928#ENSG00000177425#ENST00000552637#Other#$#ENSP00000447454#ENSG00000177425#ENST00000548426#Other#$#ENSP00000448317#ENSG00000177425#ENST00000551712#Other#	FALSE
2300	ENSG00000159086	PAXBP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Has been shown to associate with PAX3 and PAX7, and recruits H3K4 methyltransferase complex (PMID: 22862948). Has a putative DNA-binding domain, so it could contribute to specificity or even function as an independent TF	None	94104	PAX3- and PAX7-binding protein 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000159086#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$##ENSG00000159086##Other#	FALSE
2301	ENSG00000157212	PAXIP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional coactivator that associates with PAX2 (PMID: 10908331)	IPR001357	22976	PAX interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8624]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10908331	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$##ENSG00000157212##Other#	FALSE
2302	ENSG00000166228	PCBD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (UniProt: P61457)	IPR001533	5092	pterin-4 alpha-carbinolamine dehydratase 1 [Source:HGNC Symbol;Acc:HGNC:8646]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:1763325	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$##ENSG00000166228##Other#	FALSE
2303	ENSG00000169564	PCBP1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Crystal structure shows it binds ssDNA (PDB: 1ZTG).	IPR004087;IPR004088	5093	poly(rC) binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8647]	1ZTG	not tested	not tested	None	The structure is with single-stranded DNA	No	No	TF Gene Candidate_Single stranded RNA/DNA binding_Transactivation_PMIDS:2233727	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000169564#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000169564##Other#	FALSE
2304	ENSG00000197111	PCBP2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is an RBP. Structure (PDB:2PQU) is with single stranded DNA	IPR004087;IPR004088	5094	poly(rC) binding protein 2 [Source:HGNC Symbol;Acc:HGNC:8648]	2PQU	not tested	not tested	None	Structure is with single stranded DNA	No	No	TF Gene Candidate_Single stranded RNA/DNA binding_DNA Binding_PMIDS:8650178;16186123	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000197111##Other#	FALSE
2305	ENSG00000183570	PCBP3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	KH domain suggests that this is an RNA-binding protein	IPR004087;IPR004088	54039	poly(rC) binding protein 3 [Source:HGNC Symbol;Acc:HGNC:8651]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000183570#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$##ENSG00000183570##Other#	FALSE
2306	ENSG00000277258	PCGF2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	(PMID: 8521824) shows via SELEX and EMSA that the recombinant PCGF2 protein binds GACT repeats	IPR001841;IPR017907;IPR018957	7703	polycomb group ring finger 2 [Source:HGNC Symbol;Acc:HGNC:12929]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:17151361	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000277258##Other#	FALSE
2307	ENSG00000156374	PCGF6	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds GACTNGACT based on SELEX and EMSA performed in (PMID: 8521824)	IPR001841;IPR017907;IPR018957;IPR029071	84108	polycomb group ring finger 6 [Source:HGNC Symbol;Acc:HGNC:21156]	None	not tested	not tested	None	None	other	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:10500182;12167161	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000156374#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019$#ENSG00000156374#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:8521824	$#ENSP00000338845#ENSG00000156374#ENST00000337211#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_$#ENSP00000358862#ENSG00000156374#ENST00000369847#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-RING_1	FALSE
2308	ENSG00000132646	PCNA	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 5L7C). Protein barely contacts the DNA at all	None	None	proliferating cell nuclear antigen	5L7C	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 5L7C). Protein barely contacts the DNA at all	No	No	Not a TF - Evidence that it is not a TF___PMIDS:0	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2309	ENSG00000140479	PCSK6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000209;IPR000742;IPR002884;IPR006212;IPR008979;IPR009020;IPR009030;IPR010909;IPR015500;IPR022398;IPR023827;	5046	proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000381246#ENSG00000140479#ENST00000398185#Other#Furin-like_2, GF_recep_IV, PLAC, P_proprotein, Pep$#ENSP00000482760#ENSG00000140479#ENST00000611716#Other#Furin-like_2, GF_recep_IV, PLAC, P_proprotein, Pep$#ENSP00000477768#ENSG00000140479#ENST00000611967#Other#P_proprotein, Peptidase_S8, S8_pro-domain$#ENSP00000479496#ENSG00000140479#ENST00000618548#Other#Furin-like_2, GF_recep_IV, PLAC, P_proprotein, Pep$#ENSP00000482831#ENSG00000140479#ENST00000619160#Other#Furin-like_2, GF_recep_IV, P_proprotein, Peptidase$#ENSP00000481556#ENSG00000140479#ENST00000622483#Other#Furin-like_2, GF_recep_IV, P_proprotein, Peptidase$#ENSP00000452839#ENSG00000140479#ENST00000558864#Other#VSP$#ENSP00000483048#ENSG00000140479#ENST00000621185#Other#P_proprotein$#ENSP00000453771#ENSG00000140479#ENST00000558951#Other#P_proprotein$#ENSP00000453155#ENSG00000140479#ENST00000559605#Other#Furin-like_2, GF_recep_IV	FALSE
2310	ENSG00000090470	PDCD7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD. No evidence for sequence-specific DNA binding.  Included only because TFcat says its a cofactor.	None	10081	programmed cell death 7 [Source:HGNC Symbol;Acc:HGNC:8767]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10037816	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Yimeng Yin	No	None	$##ENSG00000090470##Other#	FALSE
2311	ENSG00000083642	PDS5B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR016024;	23047	PDS5 cohesin associated factor B [Source:HGNC Symbol;Acc:HGNC:20418]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000313851#ENSG00000083642#ENST00000315596#Other#Cnd1, HEAT$#ENSP00000407005#ENSG00000083642#ENST00000447833#Other#	FALSE
2312	ENSG00000197329	PELI1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Ubiquitin ligase	None	57162	E3 ubiquitin-protein ligase pellino homolog 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000197329#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000197329##Other#	FALSE
2313	ENSG00000179094	PER1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that associates with CLOCK-ARNTL heterodimers to silence the expression of their target genes (PMID: 16987893)	IPR000014;IPR022728	102465532	period circadian clock 1 [Source:HGNC Symbol;Acc:HGNC:8845]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Other_PMIDS:9856465	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$##ENSG00000179094##Other#	FALSE
2314	ENSG00000132326	PER2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that operates in the circadian clock through binding to and inhibiting the ARNTL-CLOCK heterodimer. Does not bind DNA itself )PMID: 16987893)	IPR000014;IPR022728	8864	period circadian clock 2 [Source:HGNC Symbol;Acc:HGNC:8846]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:15269772	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$##ENSG00000132326##Other#	FALSE
2315	ENSG00000049246	PER3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000014;IPR022728	8863	period circadian clock 3 [Source:HGNC Symbol;Acc:HGNC:8847]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:14701732	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Tim Hughes	No	None	$##ENSG00000049246##Other#	FALSE
2316	ENSG00000142655	PEX14	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR006785	5195	peroxisomal biogenesis factor 14 [Source:HGNC Symbol;Acc:HGNC:8856]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000142655#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11863372	$#ENSP00000349016#ENSG00000142655#ENST00000356607#Other#DUF948, HemX, Pex14_N$#ENSP00000465473#ENSG00000142655#ENST00000491661#Other#Pex14_N	FALSE
2317	ENSG00000113068	PFDN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002777;IPR009053	5201	prefoldin subunit 1 [Source:HGNC Symbol;Acc:HGNC:8866]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	$#ENSG00000113068#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8744932	$#ENSP00000261813#ENSG00000113068#ENST00000261813#Other#Prefoldin_2$#ENSP00000426383#ENSG00000113068#ENST00000510217#Other#$#ENSP00000428707#ENSG00000113068#ENST00000524074#Other#Prefoldin_2	FALSE
2318	ENSG00000137338	PGBD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	PiggyBac Transposable Element Derived 1.  Contains a SCAN domain and interacts with other SCAN proteins (see Q96JS3).  Interpro also lists without ref that it has sequence specific DNA binding activity (IEA code).  No concrete evidence available.	IPR001190;IPR003309;IPR008916;IPR029526	84547	piggyBac transposable element derived 1 [Source:HGNC Symbol;Acc:HGNC:19398]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000137338#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000259883#ENSG00000137338#ENST00000259883#Other#DDE_Tnp_1_7, SCAN	FALSE
2319	ENSG00000087157	PGS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001736;IPR016270;IPR025202	9489	phosphatidylglycerophosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:30029]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10432290	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$##ENSG00000087157##Other#	FALSE
2320	ENSG00000167085	PHB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is likely a mitochondrial chaperone and thus its roles associated with transcription are likely to be very indirect (PMID: 10835343)	None	5245	Prohibitin	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000167085#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000167085##Other#	FALSE
2321	ENSG00000215021	PHB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein has been shown to bind to TFs and function as a co-repressor. There appears to be no evidence for direct DNA-binding activity (PMID: 18629613)	IPR000163;IPR001107	11331	prohibitin 2 [Source:HGNC Symbol;Acc:HGNC:30306]	None	not tested	not tested	None	None	other	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10359819;15173318	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000215021#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18629613$#ENSG00000215021#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18629613	$#ENSP00000382362#ENSG00000215021#ENST00000399433#Other#Band_7, Med2$#ENSP00000438634#ENSG00000215021#ENST00000546111#Other#	FALSE
2322	ENSG00000112511	PHF1	Unknown	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences through PBMs, and crystal structure in complex with DNA	IPR001965;IPR002999;IPR011011;IPR019786;IPR019787;IPR025894	None	PHD finger protein 1 [Source:HGNC Symbol;Acc:HGNC:8919]	None	not tested	not tested	None	Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences through PBMs, and crystal structure in complex with DNA	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	None	FALSE
2323	ENSG00000119403	PHF19	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences of related proteins through PBMs, and crystal structure in complex with DNA	None	None	PHD finger protein 19	None	not tested	not tested	None	Recent study (PMID: 28869966) demonstrates direct, specific DNA binding to CG-rich sequences of related proteins through PBMs, and crystal structure in complex with DNA	No	No	No	No	New proteins added after initial stage	None	None	No	None	None	FALSE
2324	ENSG00000100410	PHF5A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is a known spliceosomal protein with a PhD domain.  I dont see the evidence that it binds the GJA1/Cx43 promoter, as listed on GeneCards.  The reference cited does not mention this protein as far as I can see.  In any case, binding could be indirect - the most likely role in transcription for a PHD domain protein would be as a cofactor.	IPR005345	84844	PHD finger protein 5A [Source:HGNC Symbol;Acc:HGNC:18000]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	Yes	$#ENSG00000100410#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000216252#ENSG00000100410#ENST00000216252#Other#PHF5	FALSE
2325	ENSG00000116793	PHTF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Despite its name, does not have a detectable Homeodomain.  No available evidence for DNA binding.	IPR021980	10745	putative homeodomain transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:8939]	None	not tested	not tested	None	None	No	No	Probably Not a TF - No evidence that it is a TF__Other_PMIDS:12604659;15601915	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	Yes	$#ENSG00000116793#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10729229	$#ENSP00000350428#ENSG00000116793#ENST00000357783#Other#Phtf-FEM1B_bdg$#ENSP00000377025#ENSG00000116793#ENST00000393357#Other#Phtf-FEM1B_bdg$#ENSP00000416810#ENSG00000116793#ENST00000412670#Other#$#ENSP00000404690#ENSG00000116793#ENST00000446739#Other#Phtf-FEM1B_bdg	FALSE
2326	ENSG00000006576	PHTF2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a Transcription factor homeodomain, male germ-cell domain (INTERPRO:IPR021980, PFAM:PF12129) that does not have any known DNA-binding activity. Its name comes from a fly ortholog that does contain a homeobox; but, the human gene does not.	None	None	Putative homeodomain transcription factor 2	None	not tested	not tested	None	None	No	No	No	No	New proteins added after initial stage	None	None	No	None	None	FALSE
2327	ENSG00000033800	PIAS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The protein contains a SAP motif, which has been annotated as a putative DNA-binding motif without supporting experimental evidence (PMID:10694879)	IPR003034;IPR004181;IPR023321	8554	protein inhibitor of activated STAT 1 [Source:HGNC Symbol;Acc:HGNC:2752]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9724754	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$##ENSG00000033800##Other#	FALSE
2328	ENSG00000078043	PIAS2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Sumoylates transcription factors to modulate their activities (PMID: 22406621; PMID: 15976810; PMID: 15920481)	IPR003034;IPR004181;IPR023321	9063	protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311];E3 SUMO-protein ligase PIA	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:12193603;12840021	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000317163#ENSG00000078043#ENST00000324794#Other#PINIT, zf-MIZ, zf-Nse$#ENSP00000465676#ENSG00000078043#ENST00000585916#Other#PINIT, zf-MIZ, zf-Nse$#ENSP00000443238#ENSG00000078043#ENST00000545673#Other#zf-MIZ, zf-Nse$#ENSP00000468166#ENSG00000078043#ENST00000586953#Other#SAP	FALSE
2329	ENSG00000131788	PIAS3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	PIAS-proteins regulate transcription factors by sumoylating them (PMID: 12077349)	IPR003034;IPR004181;IPR023321	10401	protein inhibitor of activated STAT 3 [Source:HGNC Symbol;Acc:HGNC:16861]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11709556	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000131788##Other#	FALSE
2330	ENSG00000105229	PIAS4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD. No evidence of DNA binding - its a known cofactor	IPR003034;IPR004181;IPR023321	51588	protein inhibitor of activated STAT 4 [Source:HGNC Symbol;Acc:HGNC:17002]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11388671	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	$#ENSG00000105229#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000105229##Other#	FALSE
2331	ENSG00000177595	PIDD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates upstream in the NFKB signaling cascade	IPR000488;IPR000906;IPR001611;IPR003591;IPR011029;IPR019502	55367	p53-induced death domain protein 1 [Source:HGNC Symbol;Acc:HGNC:16491]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000177595#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18309324	$#ENSP00000337797#ENSG00000177595#ENST00000347755#Other#Death, LRR_1, LRR_4, LRR_8, Peptidase_S68, ZU5$#ENSP00000416801#ENSG00000177595#ENST00000411829#Other#Death, LRR_1, LRR_4, LRR_8, Peptidase_S68, ZU5	FALSE
2332	ENSG00000115020	PIKFYVE	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because its in Vasquerizas 2009 with an x.  No DBD and no other evidence of DNA binding.	IPR000306;IPR000591;IPR002423;IPR002498;IPR011011;IPR016034;IPR017455;IPR027409	200576	phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$#ENSP00000264380#ENSG00000115020#ENST00000264380#Other#Cpn60_TCP1, DEP, FYVE, PIP5K$#ENSP00000308715#ENSG00000115020#ENST00000308862#Other#DEP$#ENSP00000376038#ENSG00000115020#ENST00000392202#Other#DEP$#ENSP00000384356#ENSG00000115020#ENST00000407449#Other#DEP, FYVE$#ENSP00000405736#ENSG00000115020#ENST00000452564#Other#Cpn60_TCP1, DEP, FYVE	FALSE
2333	ENSG00000137193	PIM1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Affects transcription by phosphorylating TFs (PMID: 18593906)	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	5292	Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000137193#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18593906	$#ENSP00000362608#ENSG00000137193#ENST00000373509#Other#Kdo, Kinase-like, Pkinase, Pkinase_Tyr	FALSE
2334	ENSG00000158828	PINK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	102464833	Serine/threonine-protein kinase PINK1, mitochondrial	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000158828#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000158828##Other#	FALSE
2335	ENSG00000170927	PKHD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The TIG domain is potentially DNA-binding but there is no literature evidence to suggest that PKHD1 is a TF. Membrane protein that operates upstream in the signaling cascade leading to NFKB (PMID: 21300060)	IPR002909;IPR006626;IPR011050;IPR014756;IPR019316;	5314	polycystic kidney and hepatic disease 1 (autosomal recessive) [Source:HGNC Symbol;Acc:HGNC:9016]	None	not tested	not tested	None	None	x	No	No	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Sam Lambert	No	$#ENSG00000170927#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:21300060	$#ENSP00000360158#ENSG00000170927#ENST00000371117#Other#Beta_helix, G8, NosD, PA14, TIG$#ENSP00000341097#ENSG00000170927#ENST00000340994#Other#Beta_helix, G8, NosD, PA14, TIG	FALSE
2336	ENSG00000205038	PKHD1L1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Membrane receptor (PMID: 12620974)	IPR002909;IPR006626;IPR008972;IPR011050;IPR011658;IPR014756;IPR019316;	93035	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 [Source:HGNC Symbol;Acc:HGNC:20	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000367655#ENSG00000205038#ENST00000378402#Other#Beta_helix, G8, PA14, TIG$#ENSP00000437376#ENSG00000205038#ENST00000526472#Other#Beta_helix, G8, NosD	FALSE
2337	ENSG00000069764	PLA2G10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001211;IPR013090;IPR016090	8399	phospholipase A2 group X [Source:HGNC Symbol;Acc:HGNC:9029]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000069764#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20844270	$#ENSP00000393847#ENSG00000069764#ENST00000438167#Other#Phospholip_A2_1	FALSE
2338	ENSG00000170890	PLA2G1B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001211;IPR013090;IPR016090	5319	phospholipase A2 group IB [Source:HGNC Symbol;Acc:HGNC:9030]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000170890#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - PMID:15528384	$#ENSP00000312286#ENSG00000170890#ENST00000308366#Other#Parvo_coat_N, Phospholip_A2_1$#ENSP00000413594#ENSG00000170890#ENST00000423423#Other#Phospholip_A2_1$#ENSP00000447233#ENSG00000170890#ENST00000549767#Other#Parvo_coat_N, Phospholip_A2_1	FALSE
2339	ENSG00000115956	PLEK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs	IPR000591;IPR001849	5341	pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000234313#ENSG00000115956#ENST00000234313#Other#DEP, PH, PH_11, PH_13, PH_6, PH_8, PH_9	FALSE
2340	ENSG00000100558	PLEK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR001849	26499	pleckstrin 2 [Source:HGNC Symbol;Acc:HGNC:19238]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$#ENSP00000216446#ENSG00000100558#ENST00000216446#Other#DEP, PH, PH_11, PH_3, PH_6, PH_8, PH_9$#ENSP00000450533#ENSG00000100558#ENST00000556532#Other#PH, PH_9$#ENSP00000450892#ENSG00000100558#ENST00000554395#Other#DEP, PH	FALSE
2341	ENSG00000105559	PLEKHA4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	No DBDs; no indication of DNA binding - included only because Vasquerizas 2009 included it with an x.	IPR001849;	57664	pleckstrin homology domain containing A4 [Source:HGNC Symbol;Acc:HGNC:14339]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Yimeng Yin	No	None	$#ENSP00000263265#ENSG00000105559#ENST00000263265#Other#IncA, PH, PH_11, PH_8$#ENSP00000347683#ENSG00000105559#ENST00000355496#Other#PH, PH_11, PH_8$#ENSP00000472636#ENSG00000105559#ENST00000594195#Other#IncA$#ENSP00000471274#ENSG00000105559#ENST00000594100#Other#PH, PH_11$#ENSP00000469211#ENSG00000105559#ENST00000595867#Other#$#ENSP00000471462#ENSG00000105559#ENST00000597129#Other#	FALSE
2342	ENSG00000162407	PLPP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000326	8613	phospholipid phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:9229]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000162407#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20123964	$#ENSP00000360296#ENSG00000162407#ENST00000371250#Other#C1-set_C, PAP2, PAP2_3, PAP2_C	FALSE
2343	ENSG00000188313	PLSCR1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	PLSCR1 has been demonstrated to bind a GTAACCATGTGGA sequence in the IP3R1 promoter (PMID:16091359), mediated by a specific portion of the protein.	IPR005552;IPR025659	5359	phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000188313#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:16091359	$#ENSP00000345494#ENSG00000188313#ENST00000342435#Other#Scramblase$#ENSP00000411675#ENSG00000188313#ENST00000448787#Other#Scramblase	FALSE
2344	ENSG00000114554	PLXNA1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	5361	plexin A1 [Source:HGNC Symbol;Acc:HGNC:9099]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000377061#ENSG00000114554#ENST00000393409#Other#PSI, Plexin_cytopl, RasGAP, Sema, TIG	FALSE
2345	ENSG00000076356	PLXNA2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	5362	plexin A2 [Source:HGNC Symbol;Acc:HGNC:9100]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000356000#ENSG00000076356#ENST00000367033#Other#PSI, Plexin_cytopl, RasGAP, Sema, TIG	FALSE
2346	ENSG00000130827	PLXNA3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	55558	Plexin A3 [Source:HGNC Symbol;Acc:HGNC:9101]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000358696#ENSG00000130827#ENST00000369682#Other#PSI, Plexin_cytopl, Sema, TIG	FALSE
2347	ENSG00000221866	PLXNA4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade (PMID: 12591607).	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	91584	Plexin A4 [Source:HGNC Symbol;Acc:HGNC:9102]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$##ENSG00000221866##Other#	FALSE
2348	ENSG00000164050	PLXNB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	5364	plexin B1 [Source:HGNC Symbol;Acc:HGNC:9103]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000296440#ENSG00000164050#ENST00000296440#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000351338#ENSG00000164050#ENST00000358536#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000414199#ENSG00000164050#ENST00000456774#Other#PSI, Plexin_cytopl, Sema, TIG	FALSE
2349	ENSG00000196576	PLXNB2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	23654	plexin B2 [Source:HGNC Symbol;Acc:HGNC:9104]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000400679#ENSG00000196576#ENST00000411680#Other#Plexin_cytopl$#ENSP00000387470#ENSG00000196576#ENST00000425954#Other#Sema$#ENSP00000415757#ENSG00000196576#ENST00000434732#Other#$#ENSP00000406048#ENSG00000196576#ENST00000427829#Other#TIG	FALSE
2350	ENSG00000198753	PLXNB3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	5365	plexin B3 [Source:HGNC Symbol;Acc:HGNC:9105]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000355378#ENSG00000198753#ENST00000361971#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000412454#ENSG00000198753#ENST00000448847#Other#Plexin_cytopl$#ENSP00000396048#ENSG00000198753#ENST00000455214#Other#Plexin_cytopl	FALSE
2351	ENSG00000136040	PLXNC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR016201	10154	plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000258526#ENSG00000136040#ENST00000258526#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000439225#ENSG00000136040#ENST00000545312#Other#Plexin_cytopl$#ENSP00000446720#ENSG00000136040#ENST00000547057#Other#Plexin_cytopl	FALSE
2352	ENSG00000004399	PLXND1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.	IPR001627;IPR002165;IPR002909;IPR008936;IPR013548;IPR014756;IPR016201;	23129	plexin D1 [Source:HGNC Symbol;Acc:HGNC:9107]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	None	$#ENSP00000317128#ENSG00000004399#ENST00000324093#Other#PSI, Plexin_cytopl, Sema, TIG$#ENSP00000426162#ENSG00000004399#ENST00000504689#Other#Plexin_cytopl$#ENSP00000426241#ENSG00000004399#ENST00000505237#Other#PSI, PSI_integrin, Sema$#ENSP00000427696#ENSG00000004399#ENST00000506979#Other#Plexin_cytopl	FALSE
2353	ENSG00000140464	PML	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely a transcriptional cofactor. Does not have any clear DBDs. RING-fingers are more typically protein-protein interaction domains	IPR000315;IPR001841;IPR017907;IPR021978	5371	promyelocytic leukemia [Source:HGNC Symbol;Acc:HGNC:9113]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11259576;14663483;17173041	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	None	$##ENSG00000140464##Other#	FALSE
2354	ENSG00000039650	PNKP	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 3ZVN)	None	None	polynucleotide kinase 3'-phosphatase	3ZVN	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 3ZVN)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2355	ENSG00000143442	POGZ	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Has a potential DBD that is similar to Drosophila Brinker but no other data suggesting TF function.  Likely co-factor.	IPR004875;IPR006600;IPR007087;IPR009057;IPR015880;	23126	pogo transposable element with ZNF domain [Source:HGNC Symbol;Acc:HGNC:18801]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	Yes	None	$#ENSP00000271715#ENSG00000143442#ENST00000271715#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000357856#ENSG00000143442#ENST00000368863#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000376484#ENSG00000143442#ENST00000392723#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000386836#ENSG00000143442#ENST00000409503#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000431259#ENSG00000143442#ENST00000531094#Other#DDE_1, HTH_28, HTH_Tnp_Tc5, zf-C2H2_4, zf-RRN7$#ENSP00000390156#ENSG00000143442#ENST00000439756#Other#$#ENSP00000395332#ENSG00000143442#ENST00000450842#Other#$#ENSP00000472860#ENSG00000143442#ENST00000594456#Other#	FALSE
2356	ENSG00000101868	POLA1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4Q5V)	None	None	polymerase (DNA) alpha 1, catalytic subunit	4Q5V	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4Q5V)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2357	ENSG00000070501	POLB	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase that participates in base excision repair. Binds DNA in the crystal structure (PDB: 1BPX)	None	None	polymerase (DNA) beta	1BPX	not tested	not tested	None	DNA polymerase that participates in base excision repair. Binds DNA in the crystal structure (PDB: 1BPX)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2358	ENSG00000148229	POLE3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	None	IPR003958;IPR009072	54107	polymerase (DNA) epsilon 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:13546]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000363284#ENSG00000148229#ENST00000374169#Other#BUD22, CBFD_NFYB_HMF, CENP-T_C, DUF1510, Histone$#ENSP00000363286#ENSG00000148229#ENST00000374171#Other#BUD22, CBFD_NFYB_HMF, CENP-T_C, DUF1510, Histone	FALSE
2359	ENSG00000115350	POLE4	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone-like subunit of DNA polymerase epsilon	IPR003958;IPR009072	56655	polymerase (DNA) epsilon 4, accessory subunit [Source:HGNC Symbol;Acc:HGNC:18755]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	None	$#ENSP00000420176#ENSG00000115350#ENST00000483063#Other#CBFD_NFYB_HMF, Histone, TAF	FALSE
2360	ENSG00000140521	POLG	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4ZTU)	None	None	polymerase (DNA) gamma, catalytic subunit	4ZTU	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4ZTU)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2361	ENSG00000170734	POLH	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 3JAA)	None	None	polymerase (DNA) eta	3JAA	not tested	not tested	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 3JAA)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2362	ENSG00000101751	POLI	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 1T3N)	None	None	polymerase (DNA) iota	1T3N	not tested	not tested	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 1T3N)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2363	ENSG00000122008	POLK	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 2OH2)	None	None	polymerase (DNA) kappa	2OH2	not tested	not tested	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 2OH2)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2364	ENSG00000166169	POLL	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 1RZT)	None	None	polymerase (DNA) lambda	1RZT	not tested	not tested	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 1RZT)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2365	ENSG00000122678	POLM	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase that operates on non-homologous end joining. Binds DNA in the crystal structure (PDB: 2IHM)	None	None	polymerase (DNA) mu	2IHM	not tested	not tested	None	DNA polymerase that operates on non-homologous end joining. Binds DNA in the crystal structure (PDB: 2IHM)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2366	ENSG00000130997	POLN	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4XVI)	None	None	polymerase (DNA) nu	4XVI	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4XVI)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2367	ENSG00000051341	POLQ	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4X0P)	None	None	polymerase (DNA) theta	4X0P	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4X0P)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2368	ENSG00000125630	POLR1B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	General Transcription Factor	IPR007120;IPR007121;IPR007641;IPR007642;IPR007644;IPR007645;IPR007647;IPR009674	84172	polymerase (RNA) I subunit B [Source:HGNC Symbol;Acc:HGNC:20454]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor__PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000125630##Other#	FALSE
2369	ENSG00000181222	POLR2A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contacts DNA in the structure (PDB: 5FLM)	IPR000684;IPR000722;IPR006592;IPR007066;IPR007073;IPR007075;IPR007080;IPR007081;IPR007083	5430	polymerase (RNA) II (DNA directed) polypeptide A	5FLM	not tested	not tested	None	In the structure the protein contacts DNA, but it is likely sequence nonspecific	No	No	TF Gene_Basal Transcription Factor_DNA Binding; TF PPI_PMIDS:8870495	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000181222##Other#	FALSE
2370	ENSG00000047315	POLR2B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Contacts DNA in the structure (PDB: 5FLM)	IPR007120;IPR007121;IPR007641;IPR007642;IPR007644;IPR007645;IPR007646;IPR007647	5431	polymerase (RNA) II subunit B [Source:HGNC Symbol;Acc:HGNC:9188]	5FLM	not tested	not tested	None	In the structure the protein contacts DNA but it is likely nonspecific	No	No	TF Gene_DNA-Binding: non-sequence-specific; Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_DNA Binding; Non-specific DNA; TF PPI_PMIDS:10784442	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Tim Hughes	No	None	$##ENSG00000047315##Other#	FALSE
2371	ENSG00000099817	POLR2E	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	RNA-polymerase subunit. Binds DNA in the crystal structure (PDB: 5IY6)	None	None	polymerase (RNA) II subunit E	5IY6	not tested	not tested	None	RNA-polymerase subunit. Binds DNA in the crystal structure (PDB: 5IY6)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2372	ENSG00000005075	POLR2J	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5FLM)	IPR008193;IPR009025	5439	polymerase (RNA) II subunit J [Source:HGNC Symbol;Acc:HGNC:9197]	5FLM	not tested	not tested	None	In the structure the protein does not contact the DNA	No	No	TF Gene_Basal Transcription Factor__PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Arttu Jolma	No	None	$##ENSG00000005075##Other#	FALSE
2373	ENSG00000147669	POLR2K	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5FLM)	IPR006591;IPR029040	5440	polymerase (RNA) II subunit K [Source:HGNC Symbol;Acc:HGNC:9198]	5FLM	not tested	not tested	None	In the structure the protein does not contact DNA	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:7651387	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	None	$##ENSG00000147669##Other#	FALSE
2374	ENSG00000177700	POLR2L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5FLM)	IPR000268;IPR020789;IPR023580;	5441	polymerase (RNA) II subunit L [Source:HGNC Symbol;Acc:HGNC:9199]	5FLM	not tested	not tested	None	In the structure the protein does not contact the DNA	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000324124#ENSG00000177700#ENST00000322028#Other#RNA_pol_N	FALSE
2375	ENSG00000148606	POLR3A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Transfac motifs are dubious, and do not appear to be similar to any known motifs.	IPR000722;IPR006592;IPR007066;IPR007080;IPR007081;IPR007083	11128	polymerase (RNA) III subunit A [Source:HGNC Symbol;Acc:HGNC:30074]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Sam Lambert	Pratyush Das	No	None	$#ENSP00000361446#ENSG00000148606#ENST00000372371#Other#RNA_pol_Rpb1_1, RNA_pol_Rpb1_2, RNA_pol_Rpb1_3, RN$#ENSP00000483738#ENSG00000148606#ENST00000616246#Other#RNA_pol_Rpb1_5	FALSE
2376	ENSG00000099821	POLRMT	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 4BOC)	None	None	polymerase (RNA) mitochondrial	4BOC	not tested	not tested	None	Binds DNA in the crystal structure (PDB: 4BOC)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2377	ENSG00000128513	POT1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 1XJV)	None	None	protection of telomeres 1	1XJV	not tested	not tested	None	Binds single stranded DNA in the structure (PDB: 1XJV)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2378	ENSG00000110777	POU2AF1	Unknown	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Requires POU2F1 to bind DNA. In the crystal structure (PDB:1CQT), POU2AF1 contacts both the POU2F1 and DNA major groove	IPR015389	5450	POU class 2 associating factor 1 [Source:HGNC Symbol;Acc:HGNC:9211]	1CQT	not tested	not tested	Needs POU2F1 to bind DNA, in the crystal structure	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:7623806;7779176	No	1a1, Direct HQ evidence	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000376786#ENSG00000110777#ENST00000393067#Other#PD-C2-AF1$#ENSP00000433527#ENSG00000110777#ENST00000531398#Other#PD-C2-AF1	FALSE
2379	ENSG00000109819	PPARGC1A	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504	10891	PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000109819#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19651776	$#ENSP00000264867#ENSG00000109819#ENST00000264867#Other#$#ENSP00000481498#ENSG00000109819#ENST00000613098#Other#$#ENSP00000424181#ENSG00000109819#ENST00000507380#Other#	FALSE
2380	ENSG00000155846	PPARGC1B	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains a single RRM domain, so could possibly be an RNA binding protein	IPR000504	133522	PPARG coactivator 1 beta [Source:HGNC Symbol;Acc:HGNC:30022]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11854298	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000155846#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000312649#ENSG00000155846#ENST00000309241#Other#DUF2052$#ENSP00000353638#ENSG00000155846#ENST00000360453#Other#DUF2052$#ENSP00000377855#ENSG00000155846#ENST00000394320#Other#DUF2052$#ENSP00000409364#ENSG00000155846#ENST00000434684#Other#DUF2052$#ENSP00000384403#ENSG00000155846#ENST00000403750#Other#DUF2052	FALSE
2381	ENSG00000104881	PPP1R13L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001452;IPR002110;IPR020683;	10848	protein phosphatase 1 regulatory subunit 13 like [Source:HGNC Symbol;Acc:HGNC:18838]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	Yes	None	$#ENSP00000354218#ENSG00000104881#ENST00000360957#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, SH3_1, SH3_2, SH3$#ENSP00000403902#ENSG00000104881#ENST00000418234#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, SH3_1, SH3_2, SH3$#ENSP00000466555#ENSG00000104881#ENST00000589371#Other#SH3_2, SH3_9$#ENSP00000466939#ENSG00000104881#ENST00000591986#Other#$#ENSP00000467471#ENSG00000104881#ENST00000592134#Other#$#ENSP00000466730#ENSG00000104881#ENST00000593226#Other#	FALSE
2382	ENSG00000167393	PPP2R3B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002048;IPR011992;IPR018247;	28227	protein phosphatase 2 regulatory subunit Bbeta [Source:HGNC Symbol;Acc:HGNC:13417]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000375080#ENSG00000167393#ENST00000390665#Other#EF-hand_1, EF-hand_5, EF-hand_6, EF-hand_7, EF-han$#ENSP00000371038#ENSG00000167393#ENST00000381625#Other#	FALSE
2383	ENSG00000068971	PPP2R5B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	5526	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Tim Hughes	No	$#ENSG00000068971#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000068971##Other#	FALSE
2384	ENSG00000138814	PPP3CA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	5530	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000138814#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000138814##Other#	FALSE
2385	ENSG00000148840	PPRC1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504	23082	peroxisome proliferator-activated receptor gamma, coactivator-related 1 [Source:HGNC Symbol;Acc:HGNC	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000148840#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000278070#ENSG00000148840#ENST00000278070#Other#$#ENSP00000359029#ENSG00000148840#ENST00000370012#Other#$#ENSP00000399743#ENSG00000148840#ENST00000413464#Other#RSRP, SR-25	FALSE
2386	ENSG00000102103	PQBP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Has a WW domain. May interact with Pol II, but no indication of sequence specific DNA binding	IPR001202	10084	polyglutamine binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9330]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10332029	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Tim Hughes	No	None	$##ENSG00000102103##Other#	FALSE
2387	ENSG00000133246	PRAM1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001452;IPR029294	84106	PML-RARA regulated adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:30091]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$#ENSP00000408342#ENSG00000133246#ENST00000423345#Other#SH3_2, hSH3$#ENSP00000471634#ENSG00000133246#ENST00000600262#Other#	FALSE
2388	ENSG00000165828	PRAP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR007087;IPR015880;IPR027922	118471	proline rich acidic protein 1 [Source:HGNC Symbol;Acc:HGNC:23304]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000416126#ENSG00000165828#ENST00000433452#Other#PRAP$#ENSP00000486265#ENSG00000165828#ENST00000463201#Other#PRAP	FALSE
2389	ENSG00000197870	PRB3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Human salivary glycoprotein	IPR026086;	5544	proline rich protein BstNI subfamily 3	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000371264#ENSG00000197870#ENST00000381842#Other#Pro-rich$#ENSP00000442626#ENSG00000197870#ENST00000538488#Other#Pro-rich	FALSE
2390	ENSG00000126856	PRDM7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Only has KRAB and SET domains - no C2H2 ZFs.	IPR001214;IPR001909;IPR003655;IPR019041	11105	PR domain 7 [Source:HGNC Symbol;Acc:HGNC:9351]	None	Full	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	None	$#ENSP00000396732#ENSG00000126856#ENST00000449207#Other#KRAB, SET, SSXRD	FALSE
2391	ENSG00000165672	PRDX3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000866;IPR012336;IPR019479	10935	peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354];Thioredoxin-dependent peroxide reductase, mitocho	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000165672#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12492477	$#ENSP00000298510#ENSG00000165672#ENST00000298510#Other#1-cysPrx_C, AhpC-TSA, Redoxin	FALSE
2392	ENSG00000138073	PREB	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	In vitro gel-shift experiments show that PREB binds specific promoter sequences (PMID: 10194769; PMID: 19426980) without the presence of a canonical DBD	IPR001680;IPR011047;IPR017986;	10113	prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356]	None	Full	not tested	None	None	other	No	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10194769	No	4a, two or more datasets predict it as a TF	Laura Campitelli	Sam Lambert	No	None	$#ENSP00000260643#ENSG00000138073#ENST00000260643#Other#ANAPC4_WD40, WD40$#ENSP00000407036#ENSG00000138073#ENST00000430533#Other#$#ENSP00000397036#ENSG00000138073#ENST00000456259#Other#$#ENSP00000384032#ENSG00000138073#ENST00000406567#Other#ANAPC4_WD40, WD40	FALSE
2393	ENSG00000124126	PREX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because Vasquerizas 2009 includes it with an x.  No DBD and no other data to support being a TF.	IPR000219;IPR000591;IPR001331;IPR001478;IPR001849;	57580	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [Source:HGNC Symbol;Acc:HGN	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	None	$#ENSP00000361009#ENSG00000124126#ENST00000371941#Other#DEP, PDZ, PDZ_2, PH, PH_10, RhoGEF$#ENSP00000481444#ENSG00000124126#ENST00000620554#Other#	FALSE
2394	ENSG00000046889	PREX2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000219;IPR000591;IPR001331;IPR001478;IPR001849;	80243	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 [Source:HGNC Symbol;Acc:HGN	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$#ENSP00000288368#ENSG00000046889#ENST00000288368#Other#DEP, PDZ, PDZ_2, PH, RhoGEF	FALSE
2395	ENSG00000134551	PRH2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR026086;	5555	proline rich protein HaeIII subfamily 2	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000371271#ENSG00000134551#ENST00000381847#Other#Pro-rich$#ENSP00000379682#ENSG00000134551#ENST00000396400#Other#Pro-rich	FALSE
2396	ENSG00000146143	PRIM2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds DNA-RNA hybrid in the structure (PDB: 5F0Q)	None	None	primase (DNA) subunit 2	5F0Q	not tested	not tested	None	Binds DNA-RNA hybrid in the structure (PDB: 5F0Q)	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2397	ENSG00000164306	PRIMPOL	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Involved in DNA replication. Binds DNA in the crystal structure (PDB: 5L2X), presumably non-specifically.	None	None	primase and DNA directed polymerase	5L2X	not tested	not tested	None	Involved in DNA replication. Binds DNA in the crystal structure (PDB: 5L2X), presumably non-specifically.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2398	ENSG00000166501	PRKCB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000008;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR014375;IPR017441;IPR017892;IPR020454	5579	protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000166501#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000305355#ENSG00000166501#ENST00000303531#Other#C1_1, C1_2, C2, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000318315#ENSG00000166501#ENST00000321728#Other#C1_1, C1_2, C2, CEP76-C2, Kinase-like, Pkinase, Pk$#ENSP00000458564#ENSG00000166501#ENST00000466124#Other#$#ENSP00000457980#ENSG00000166501#ENST00000472066#Other#Pkinase, Pkinase_Tyr$#ENSP00000454428#ENSG00000166501#ENST00000498058#Other#C1_1	FALSE
2399	ENSG00000027075	PRKCH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a kinase that activates another kinase leading to degradation of NFKB inhibitor NFKBIA (PMID: 21820409)	IPR000008;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR014376;IPR017441;IPR017892;IPR020454;	5583	protein kinase C eta [Source:HGNC Symbol;Acc:HGNC:9403]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000027075#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21820409	$#ENSP00000329127#ENSG00000027075#ENST00000332981#Other#C1_1, C1_2, C2, FTA2, Kinase-like, Pkinase, Pkinas$#ENSP00000450981#ENSG00000027075#ENST00000555082#Other#C1_1, C1_2, FTA2, Kinase-like, Pkinase, Pkinase_C,$#ENSP00000451871#ENSG00000027075#ENST00000555185#Other#APH, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000451205#ENSG00000027075#ENST00000555906#Other#C1_1$#ENSP00000452330#ENSG00000027075#ENST00000556164#Other#C1_1$#ENSP00000452528#ENSG00000027075#ENST00000557473#Other#C1_1	FALSE
2400	ENSG00000163558	PRKCI	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase that operates upstream in the signaling cascade that leads to NFKB	IPR000270;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR012233;IPR017441;IPR017892;IPR020454	5584	protein kinase C iota [Source:HGNC Symbol;Acc:HGNC:9404]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000163558#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10467349	$#ENSP00000295797#ENSG00000163558#ENST00000295797#Other#C1_1, Kinase-like, PB1, Pkinase, Pkinase_C, Pkinas	FALSE
2401	ENSG00000065675	PRKCQ	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000008;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR014376;IPR017441;IPR017892;IPR020454;	5588	protein kinase C theta [Source:HGNC Symbol;Acc:HGNC:9410]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000065675#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:16356855	$#ENSP00000263125#ENSG00000065675#ENST00000263125#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina$#ENSP00000441752#ENSG00000065675#ENST00000539722#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina$#ENSP00000380361#ENSG00000065675#ENST00000397176#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina$#ENSP00000483428#ENSG00000065675#ENST00000610727#Other#C1_1, C1_2, Kinase-like, Pkinase, Pkinase_C, Pkina	FALSE
2402	ENSG00000067606	PRKCZ	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000270;IPR000719;IPR000961;IPR002219;IPR002290;IPR008271;IPR011009;IPR012233;IPR017441;IPR017892;IPR020454	5590	protein kinase C zeta [Source:HGNC Symbol;Acc:HGNC:9412]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	$#ENSG00000067606#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000367830#ENSG00000067606#ENST00000378567#Other#C1_1, C1_2, Kinase-like, PB1, Pkinase, Pkinase_C, $#ENSP00000383712#ENSG00000067606#ENST00000400921#Other#Kinase-like, Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000426412#ENSG00000067606#ENST00000461106#Other#C1_1, Kinase-like, Pkinase, Pkinase_C, Pkinase_Tyr$#ENSP00000424228#ENSG00000067606#ENST00000470596#Other#Pkinase$#ENSP00000421219#ENSG00000067606#ENST00000470986#Other#Pkinase$#ENSP00000427134#ENSG00000067606#ENST00000466352#Other#$#ENSP00000422349#ENSG00000067606#ENST00000471018#Other#$#ENSP00000425317#ENSG00000067606#ENST00000482686#Other#$#ENSP00000424763#ENSG00000067606#ENST00000486681#Other#Pkinase$#ENSP00000422764#ENSG00000067606#ENST00000497183#Other#Pkinase	FALSE
2403	ENSG00000184304	PRKD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001849;IPR002219;IPR002290;IPR008271;IPR011009;IPR015727;IPR017441;IPR020454	5587	protein kinase D1 [Source:HGNC Symbol;Acc:HGNC:9407]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000184304#GO:0032793#positive regulation of CREB transcription factor activity#IGI - PMID:20497126$#ENSG00000184304#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12505989	$#ENSP00000333568#ENSG00000184304#ENST00000331968#Other#C1_1, C1_2, Kdo, Kinase-like, PH, Pkinase, Pkinase$#ENSP00000447333#ENSG00000184304#ENST00000546371#Other#PH$#ENSP00000446866#ENSG00000184304#ENST00000549503#Other#C1_1, C1_2	FALSE
2404	ENSG00000105287	PRKD2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR001849;IPR002219;IPR002290;IPR008271;IPR011009;IPR015727;IPR017441;IPR020454	25865	protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	$#ENSG00000105287#GO:0032793#positive regulation of CREB transcription factor activity#IGI - PMID:20497126$#ENSG00000105287#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19192391$#ENSG00000105287#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:15604256, PMID:16928771	$#ENSP00000291281#ENSG00000105287#ENST00000291281#Other#C1_1, C1_2, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000472987#ENSG00000105287#ENST00000593363#Other#$#ENSP00000470804#ENSG00000105287#ENST00000595515#Other#C1_1, C1_2, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000472744#ENSG00000105287#ENST00000600194#Other#C1_1, C1_2, Kdo, Kinase-like, Pkinase, Pkinase_Tyr	FALSE
2405	ENSG00000185345	PRKN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiquitin ligase	IPR000626;IPR002867;IPR003977;IPR029071	5071	parkin RBR E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:8607]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000185345#GO:0003700#sequence-specific DNA binding transcription factor activity#IC - PMID:23985028	$#ENSP00000343589#ENSG00000185345#ENST00000338468#Other#IBR$#ENSP00000355862#ENSG00000185345#ENST00000366896#Other#IBR, Rad60-SLD, ubiquitin$#ENSP00000355863#ENSG00000185345#ENST00000366897#Other#IBR, Rad60-SLD, Rad60-SLD_2, ubiquitin$#ENSP00000355865#ENSG00000185345#ENST00000366898#Other#IBR, Rad60-SLD, Rad60-SLD_2, ubiquitin$#ENSP00000483773#ENSG00000185345#ENST00000610470#Other#IBR	FALSE
2406	ENSG00000160310	PRMT2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001452;IPR007848;IPR025799;IPR029063	3275	protein arginine methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:5186]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000160310#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:16648481	$#ENSP00000291705#ENSG00000160310#ENST00000291705#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000335490#ENSG00000160310#ENST00000334494#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000347906#ENSG00000160310#ENST00000355680#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000380760#ENSG00000160310#ENST00000397638#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000397266#ENSG00000160310#ENST00000440086#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000411984#ENSG00000160310#ENST00000451211#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000407463#ENSG00000160310#ENST00000458387#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000380752#ENSG00000160310#ENST00000397628#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000380759#ENSG00000160310#ENST00000397637#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met$#ENSP00000406127#ENSG00000160310#ENST00000455177#Other#MTS, Met_10, Methyltransf_11, Methyltransf_18, Met	FALSE
2407	ENSG00000171867	PRNP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000817;IPR022416;IPR025860	5621	prion protein [Source:HGNC Symbol;Acc:HGNC:9449]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000171867#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000368752#ENSG00000171867#ENST00000379440#Other#Prion, Prion_bPrPp$#ENSP00000411599#ENSG00000171867#ENST00000424424#Other#Prion, Prion_bPrPp$#ENSP00000399376#ENSG00000171867#ENST00000430350#Other#Prion, Prion_bPrPp$#ENSP00000415284#ENSG00000171867#ENST00000457586#Other#Prion, Prion_bPrPp	FALSE
2408	ENSG00000100902	PSMA6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000426;IPR001353;IPR023332;IPR029055	5687	proteasome subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:9535]	None	not tested	Yes	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000100902#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:16845397	$#ENSP00000261479#ENSG00000100902#ENST00000261479#Other#Proteasome, Proteasome_A_N$#ENSP00000444844#ENSG00000100902#ENST00000540871#Other#Proteasome$#ENSP00000452566#ENSG00000100902#ENST00000555764#Other#Proteasome$#ENSP00000479620#ENSG00000100902#ENST00000622405#Other#Proteasome$#ENSP00000452603#ENSG00000100902#ENST00000553809#Other#Proteasome, Proteasome_A_N$#ENSP00000451171#ENSG00000100902#ENST00000556221#Other#Proteasome	FALSE
2409	ENSG00000087191	PSMC5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003593;IPR003959;IPR003960;IPR005937;IPR027417	5705	proteasome 26S subunit, ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9552]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:7776974;9173976	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$##ENSG00000087191##Other#	FALSE
2410	ENSG00000101843	PSMD10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GO annotation has no evidence of DNA-binding activity; only modulation of NF-kappaB activity (PMID: 18040287)	IPR002110;IPR020683	5716	proteasome 26S subunit, non-ATPase 10 [Source:HGNC Symbol;Acc:HGNC:9555]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000101843#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18040287	$#ENSP00000217958#ENSG00000101843#ENST00000217958#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000354906#ENSG00000101843#ENST00000361815#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000345963#ENSG00000101843#ENST00000340200#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5	FALSE
2411	ENSG00000108671	PSMD11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000717;IPR013143	5717	proteasome 26S subunit, non-ATPase 11 [Source:HGNC Symbol;Acc:HGNC:9556]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000261712#ENSG00000108671#ENST00000261712#Other#DDRGK, PCI, TPR_12$#ENSP00000393185#ENSG00000108671#ENST00000457654#Other#DDRGK, PCI, TPR_12$#ENSP00000464434#ENSG00000108671#ENST00000579451#Other#$#ENSP00000462683#ENSG00000108671#ENST00000578213#Other#	FALSE
2412	ENSG00000197170	PSMD12	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000717;	5718	proteasome 26S subunit, non-ATPase 12 [Source:HGNC Symbol;Acc:HGNC:9557]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000348442#ENSG00000197170#ENST00000356126#Other#PCI$#ENSP00000349667#ENSG00000197170#ENST00000357146#Other#PCI	FALSE
2413	ENSG00000121390	PSPC1	Unknown	No	ssDNA/RNA binding	Low specificity DNA-binding protein	No motif	None	Contains RRMs and no DBDs. Mouse orhtolog has been found in androgen receptor complexes (PMID: 16641145) but no DNA-binding activity has been shown.	None	Has no Entrez identifier	Paraspeckle component 1	None	not tested	not tested	None	Contains RRMs and no DBDs. Mouse orhtolog has been found in androgen receptor complexes (PMID: 16641145) but no DNA-binding activity has been shown.	No	No	No	No	New proteins added after initial stage	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
2414	ENSG00000185920	PTCH1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000731;IPR003392;IPR004766	5727	patched 1 [Source:HGNC Symbol;Acc:HGNC:9585]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__DNA Binding_PMIDS:16229683	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000185920#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:16229683	$#ENSP00000364420#ENSG00000185920#ENST00000375271#Other#Patched, Sterol-sensing$#ENSP00000414823#ENSG00000185920#ENST00000429896#Other#Patched, Sterol-sensing$#ENSP00000449745#ENSG00000185920#ENST00000468211#Other#$#ENSP00000448843#ENSG00000185920#ENST00000546820#Other#$#ENSP00000447878#ENSG00000185920#ENST00000547672#Other#$#ENSP00000450131#ENSG00000185920#ENST00000551630#Other#$#ENSP00000447797#ENSG00000185920#ENST00000553011#Other#	FALSE
2415	ENSG00000171862	PTEN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000008;IPR000340;IPR003595;IPR014020;IPR016130;IPR017361;IPR029021;IPR029023	5728	phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588];Phosphatidylinositol 3,4,5-trispho	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000171862#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:20123964	$#ENSP00000361021#ENSG00000171862#ENST00000371953#Other#DSPc, PTEN_C2, PTPlike_phytase, Y_phosphatase, Y_p$#ENSP00000483066#ENSG00000171862#ENST00000472832#Other#DUF3256, PTEN_C2$#ENSP00000477517#ENSG00000171862#ENST00000610634#Other#DSPc, PTPlike_phytase, Y_phosphatase, Y_phosphatas	FALSE
2416	ENSG00000124212	PTGIS	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	It is a cytochrome p450 enzyme	IPR001128;IPR002403;IPR024204;IPR027286	5740	prostaglandin I2 (prostacyclin) synthase [Source:HGNC Symbol;Acc:HGNC:9603];Prostacyclin synthase	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	$#ENSG00000124212#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:20159982	$#ENSP00000244043#ENSG00000124212#ENST00000244043#Other#p450	FALSE
2417	ENSG00000152266	PTH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001415;IPR003625	5741	parathyroid hormone [Source:HGNC Symbol;Acc:HGNC:9606]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000152266#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IMP - PMID:17696759	$#ENSP00000282091#ENSG00000152266#ENST00000282091#Other#ABC_ATPase, Parathyroid$#ENSP00000433208#ENSG00000152266#ENST00000529816#Other#ABC_ATPase, Parathyroid	FALSE
2418	ENSG00000164611	PTTG1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GO annotation has no evidence for DNA-binding activity (PMID:9811450), only transcriptional activation in reporter experiments	IPR006940	9232	pituitary tumor-transforming 1 [Source:HGNC Symbol;Acc:HGNC:9690]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000164611#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9811450	$#ENSP00000344936#ENSG00000164611#ENST00000352433#Other#Securin$#ENSP00000377536#ENSG00000164611#ENST00000393964#Other#Securin$#ENSP00000430642#ENSG00000164611#ENST00000520452#Other#Securin$#ENSP00000431068#ENSG00000164611#ENST00000517480#Other#Securin	FALSE
2419	ENSG00000080608	PUM3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds dsDNA in the crystal structure (PDB: 4WZW). Makes extensive contacts with the backbone that cause shape changes and could possibly lead to specificity.	None	9933	pumilio RNA binding family member 3	4WZW	not tested	not tested	None	Binds dsDNA in the crystal structure (PDB: 4WZW). Makes extensive contacts with the backbone that cause shape changes and could possibly lead to specificity.	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2420	ENSG00000185129	PURA	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds dsDNA (PMID: 15282343) and  ssDNA (PMID: 1448097) specifically	IPR006628	5813	purine rich element binding protein A [Source:HGNC Symbol;Acc:HGNC:9701];Transcriptional activator p	None	not tested	not tested	None	None	No	Yes	TF Gene_Single stranded RNA/DNA binding_DNA Binding_PMIDS:1448097;1545807;15282343	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Sam Lambert	Yes	$#ENSG00000185129#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#TAS - PMID:9334258	$#ENSP00000332706#ENSG00000185129#ENST00000331327#Other#DUF3276, PurA	FALSE
2421	ENSG00000146676	PURB	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds dsDNA (PMID: 15282343) and  ssDNA (PMID: 1448097) specifically	IPR006628	100616393	purine rich element binding protein B [Source:HGNC Symbol;Acc:HGNC:9702]	None	not tested	not tested	None	None	No	No	TF Gene_Single stranded RNA/DNA binding_DNA Binding_PMIDS:15282343	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	Yes	$#ENSG00000146676#GO:0001227#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$##ENSG00000146676##Other#	FALSE
2422	ENSG00000172733	PURG	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Paralogs PURA and PURB bind dsDNA (PMID: 15282343) and ssDNA (PMID: 1448097) specifically.	IPR006628	29942	Purine rich element binding protein G	None	not tested	not tested	None	Paralogs PURA and PURB bind dsDNA (PMID: 15282343) and ssDNA (PMID: 1448097) specifically.	No	No	No	No	New proteins added after initial stage	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
2423	ENSG00000103490	PYCARD	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001315;IPR004020;IPR011029	29108	PYD and CARD domain containing [Source:HGNC Symbol;Acc:HGNC:16608];Apoptosis-associated speck-like p	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000103490#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:16585594$#ENSG00000103490#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:19494289$#ENSG00000103490#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12646168, PMID:12656673	$#ENSP00000247470#ENSG00000103490#ENST00000247470#Other#CARD, PYRIN$#ENSP00000340441#ENSG00000103490#ENST00000350605#Other#CARD, PYRIN$#ENSP00000455141#ENSG00000103490#ENST00000561508#Other#PYRIN	FALSE
2424	ENSG00000169900	PYDC1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR004020;IPR011029	260434	pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30261]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000169900#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:12656673 | IMP - PMID:24871464	$#ENSP00000304336#ENSG00000169900#ENST00000302964#Other#PYRIN	FALSE
2425	ENSG00000253548	PYDC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that regulates NFKB activity	IPR004020;IPR011029	None	pyrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:33512]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000253548#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:17339483, PMID:24871464	$##ENSG00000253548##Other#	FALSE
2426	ENSG00000198218	QRICH1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001315;IPR011029;IPR021893	54870	glutamine rich 1 [Source:HGNC Symbol;Acc:HGNC:24713]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000198218#GO:0000981#sequence-specific DNA binding RNA polymerase II transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000378830#ENSG00000198218#ENST00000395443#Other#CARD, DUF3504$#ENSP00000350094#ENSG00000198218#ENST00000357496#Other#CARD, DUF3504$#ENSP00000412890#ENSG00000198218#ENST00000424300#Other#CARD, DUF3504$#ENSP00000413051#ENSG00000198218#ENST00000450685#Other#CARD	FALSE
2427	ENSG00000276600	RAB7B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein activates NFKB (PMID: 20953574)	IPR001806;IPR002041;IPR003578;IPR003579;IPR005225;IPR020849;IPR027417	338382	RAB7B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30513]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000276600#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:20953574	$#ENSP00000482499#ENSG00000276600#ENST00000617070#Other#ATP_bind_1, Arf, DUF258, G-alpha, GTP_EFTU, Gtr1_R$#ENSP00000479762#ENSG00000276600#ENST00000617991#Other#ATP_bind_1, Arf, DUF258, G-alpha, GTP_EFTU, Gtr1_R$#ENSP00000485563#ENSG00000276600#ENST00000622969#Other#Ras$#ENSP00000485386#ENSG00000276600#ENST00000623893#Other#AAA_22, ATP_bind_1, Arf, G-alpha, GTP_EFTU, Gtr1_R	FALSE
2428	ENSG00000164754	RAD21	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Motifs are suspicious; protein is a component of the cohesin complex and there is no evidence for direct binding to DNA.	IPR006909;IPR006910	100500914	RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Yimeng Yin	Arttu Jolma	No	$#ENSG00000164754#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$#ENSP00000297338#ENSG00000164754#ENST00000297338#Other#Rad21_Rec8, Rad21_Rec8_N, SMC_ScpA$#ENSP00000430273#ENSG00000164754#ENST00000517749#Other#Rad21_Rec8, SMC_ScpA$#ENSP00000428003#ENSG00000164754#ENST00000518055#Other#Rad21_Rec8, SMC_ScpA$#ENSP00000428513#ENSG00000164754#ENST00000523986#Other#Rad21_Rec8, SMC_ScpA$#ENSP00000427923#ENSG00000164754#ENST00000517485#Other#Rad21_Rec8_N$#ENSP00000428158#ENSG00000164754#ENST00000522699#Other#Rad21_Rec8_N	FALSE
2429	ENSG00000051180	RAD51	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Functions in homologous recombination DNA-repair. Binds DNA with low specificity (PMID:10390347)	IPR003593;IPR010995;IPR011941;IPR013632;IPR016467;IPR020587;IPR020588;IPR027417	5888	RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000267868#ENSG00000051180#ENST00000267868#Other#AAA_25, ATPase, HHH_5, Rad51, RecA$#ENSP00000406602#ENSG00000051180#ENST00000423169#Other#AAA_25, ATPase, HHH_5, Rad51, RecA$#ENSP00000372088#ENSG00000051180#ENST00000382643#Other#AAA_25, HHH_5, Rad51, RecA$#ENSP00000433924#ENSG00000051180#ENST00000532743#Other#AAA_25, HHH_5, Rad51, RecA$#ENSP00000454176#ENSG00000051180#ENST00000557850#Other#AAA_25, HHH_5, Rad51$#ENSP00000431897#ENSG00000051180#ENST00000526763#Other#HHH_5	FALSE
2430	ENSG00000166349	RAG1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds DNA specifically (PMID: 10066757)	IPR001841;IPR017907;IPR018957;IPR019485;IPR023336;IPR024627	5896	recombination activating gene 1 [Source:HGNC Symbol;Acc:HGNC:9831]	3GNA	not tested	not tested	None	Protein contacts DNA in the structure;Operates in lymphocyte development in a process known as V(D)J recombination	x	No	No	No	1a1, Direct HQ evidence	Pratyush Das	Yimeng Yin	No	None	$#ENSP00000299440#ENSG00000166349#ENST00000299440#Other#RAG1, RAG1_imp_bd, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_	FALSE
2431	ENSG00000108557	RAI1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Chromatin remodeler	IPR001965	10743	retinoic acid induced 1 [Source:HGNC Symbol;Acc:HGNC:9834]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000108557#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000323074#ENSG00000108557#ENST00000353383#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000379120#ENSG00000108557#ENST00000395774#Other#$#ENSP00000463984#ENSG00000108557#ENST00000583166#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000463607#ENSG00000108557#ENST00000471135#Other#	FALSE
2432	ENSG00000079337	RAPGEF3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD and no evidence its a TF - included only because it has an x in Vaquerizas 2009	IPR000591;IPR000595;IPR000651;IPR001895;IPR002373;IPR018490;IPR019804;IPR029071	10411	Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Tim Hughes	No	None	$#ENSP00000373864#ENSG00000079337#ENST00000389212#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000378764#ENSG00000079337#ENST00000395358#Other#DEP, RasGEF_N, cNMP_binding$#ENSP00000395708#ENSG00000079337#ENST00000449771#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000448480#ENSG00000079337#ENST00000548919#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000448804#ENSG00000079337#ENST00000495953#Other#DEP	FALSE
2433	ENSG00000091428	RAPGEF4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000159;IPR000591;IPR000595;IPR000651;IPR001895;IPR002373;IPR018490;IPR019804;IPR029071;	11069	Rap guanine nucleotide exchange factor 4 [Source:HGNC Symbol;Acc:HGNC:16626]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000380271#ENSG00000091428#ENST00000397081#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000380276#ENSG00000091428#ENST00000397087#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000438011#ENSG00000091428#ENST00000535187#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000440135#ENSG00000091428#ENST00000538974#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000440250#ENSG00000091428#ENST00000540783#Other#DEP, RasGEF, RasGEF_N, cNMP_binding$#ENSP00000380274#ENSG00000091428#ENST00000397085#Other#RasGEF	FALSE
2434	ENSG00000136237	RAPGEF5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR000651;IPR001895;IPR019804;IPR029071;	9771	Rap guanine nucleotide exchange factor 5 [Source:HGNC Symbol;Acc:HGNC:16862]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000384044#ENSG00000136237#ENST00000401957#Other#RA, RasGEF, RasGEF_N$#ENSP00000384870#ENSG00000136237#ENST00000405243#Other#DEP$#ENSP00000479340#ENSG00000136237#ENST00000620335#Other#RasGEF, RasGEF_N	FALSE
2435	ENSG00000139687	RB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Classic co-factor	IPR002719;IPR002720;IPR013763;IPR015030;IPR024599	5925	RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884];Retinoblastoma-associated protei	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:16007137	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Laura Campitelli	No	$#ENSG00000139687#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:3657987$#ENSG00000139687#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:9529249	$#ENSP00000267163#ENSG00000139687#ENST00000267163#Other#DUF3452, RB_A, RB_B, Rb_C	FALSE
2436	ENSG00000102054	RBBP7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001680;IPR017986;IPR019775;IPR020472;IPR022052	5931	RB binding protein 7, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9890]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16950772	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$##ENSG00000102054##Other#	FALSE
2437	ENSG00000125826	RBCK1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Fairly well-studied E3 ubiquitin-protein ligase. But EMSA data exist demonstrating binding to TGG-containing DNA (PMID: 9514928)	IPR000626;IPR001841;IPR001876;IPR002867;IPR017907;IPR029071	10616	RANBP2-type and C3HC4-type zinc finger containing 1 [Source:HGNC Symbol;Acc:HGNC:15864]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000125826#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:17449468$#ENSG00000125826#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19136968	$#ENSP00000254960#ENSG00000125826#ENST00000353660#Other#IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11$#ENSP00000348632#ENSG00000125826#ENST00000356286#Other#IBR, ubiquitin, zf-C3HC4_2, zf-C3HC4_4, zf-RING_11$#ENSP00000371616#ENSG00000125826#ENST00000382181#Other#IBR$#ENSP00000417173#ENSG00000125826#ENST00000475269#Other#$#ENSP00000383106#ENSG00000125826#ENST00000400247#Other#$#ENSP00000415080#ENSG00000125826#ENST00000411647#Other#ubiquitin$#ENSP00000393841#ENSG00000125826#ENST00000414880#Other#ubiquitin, zf-RanBP	FALSE
2438	ENSG00000080839	RBL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002719;IPR002720;IPR013763;IPR015030;IPR024599	5933	RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding; Other_PMIDS:14716294	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$##ENSG00000080839##Other#	FALSE
2439	ENSG00000103479	RBL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-repressor	IPR002719;IPR002720;IPR013763;IPR024599	5934	RB transcriptional corepressor like 2 [Source:HGNC Symbol;Acc:HGNC:9894]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000103479##Other#	FALSE
2440	ENSG00000182872	RBM10	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein	IPR000467;IPR000504;IPR001876;IPR007087	8241	RNA binding motif protein 10 [Source:HGNC Symbol;Acc:HGNC:9896]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$#ENSP00000328848#ENSG00000182872#ENST00000329236#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000366829#ENSG00000182872#ENST00000377604#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000486115#ENSG00000182872#ENST00000628161#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000329659#ENSG00000182872#ENST00000345781#Other#G-patch, G-patch_2, zf-RanBP	FALSE
2441	ENSG00000203867	RBM20	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely an RNA-binding protein	IPR000504;IPR000690;IPR003604;	282996	RNA binding motif protein 20 [Source:HGNC Symbol;Acc:HGNC:27424]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000358532#ENSG00000203867#ENST00000369519#Other#RRM_5, zf-C2H2_jaz	FALSE
2442	ENSG00000086589	RBM22	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA binding protein (PMID: 17045351)	IPR000504;IPR000571	55696	RNA binding motif protein 22 [Source:HGNC Symbol;Acc:HGNC:25503]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$#ENSP00000199814#ENSG00000086589#ENST00000199814#Other#FYVE$#ENSP00000412118#ENSG00000086589#ENST00000447771#Other#$#ENSP00000430946#ENSG00000086589#ENST00000521464#Other#$#ENSP00000428154#ENSG00000086589#ENST00000518917#Other#	FALSE
2443	ENSG00000139746	RBM26	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein (PMID: 22681889; PMID: 22658674)	IPR000504;IPR000571;IPR002483;	64062	RNA binding motif protein 26 [Source:HGNC Symbol;Acc:HGNC:20327]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000267229#ENSG00000139746#ENST00000267229#Other#PWI$#ENSP00000390222#ENSG00000139746#ENST00000438724#Other#PWI$#ENSP00000483408#ENSG00000139746#ENST00000622611#Other#PWI$#ENSP00000401474#ENSG00000139746#ENST00000449987#Other#	FALSE
2444	ENSG00000091009	RBM27	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely an RNA-binding protein	IPR000504;IPR000571;IPR002483;	54439	RNA binding motif protein 27 [Source:HGNC Symbol;Acc:HGNC:29243]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000265271#ENSG00000091009#ENST00000265271#Other#PWI	FALSE
2445	ENSG00000003756	RBM5	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein that binds RNA with two RRM-domains and regulates splicing (PMID: 24486491)	IPR000467;IPR000504;IPR001876;IPR007087	10181	RNA binding motif protein 5 [Source:HGNC Symbol;Acc:HGNC:9902]	None	not tested	not tested	None	Has only a single ZNFC2H2	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	None	$#ENSP00000343054#ENSG00000003756#ENST00000347869#Other#G-patch, G-patch_2, zf-RanBP$#ENSP00000419534#ENSG00000003756#ENST00000469838#Other#$#ENSP00000384872#ENSG00000003756#ENST00000404526#Other#$#ENSP00000390711#ENSG00000003756#ENST00000441305#Other#	FALSE
2446	ENSG00000004534	RBM6	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein that binds RNA with two RRM-domains and regulates splicing (PMID: 24332178)	IPR000467;IPR000504	10180	RNA binding motif protein 6 [Source:HGNC Symbol;Acc:HGNC:9903]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	None	$#ENSP00000266022#ENSG00000004534#ENST00000266022#Other#G-patch, Pentapeptide_4$#ENSP00000393530#ENSG00000004534#ENST00000442092#Other#G-patch$#ENSP00000392475#ENSG00000004534#ENST00000421682#Other#G-patch$#ENSP00000392939#ENSG00000004534#ENST00000422955#Other#G-patch$#ENSP00000389763#ENSG00000004534#ENST00000433811#Other#	FALSE
2447	ENSG00000159200	RCAN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	SH3 domain protein that interacts with calcineurin. GO annotation and abstract in (PMID: 8595418) appear erroneous - mentions a binding domain in the abstract, but no evidence is provided in the paper.	IPR006931	1827	regulator of calcineurin 1 [Source:HGNC Symbol;Acc:HGNC:3040];Calcipressin-1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000159200#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8595418	$#ENSP00000320768#ENSG00000159200#ENST00000313806#Other#Calcipressin$#ENSP00000370524#ENSG00000159200#ENST00000381132#Other#Calcipressin$#ENSP00000382214#ENSG00000159200#ENST00000399272#Other#Calcipressin$#ENSP00000392438#ENSG00000159200#ENST00000443408#Other#Calcipressin$#ENSP00000419624#ENSG00000159200#ENST00000482533#Other#Calcipressin$#ENSP00000370527#ENSG00000159200#ENST00000381135#Other#Calcipressin$#ENSP00000419252#ENSG00000159200#ENST00000487990#Other#Calcipressin$#ENSP00000477155#ENSG00000159200#ENST00000492600#Other#Calcipressin	FALSE
2448	ENSG00000004700	RECQL	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	ATP dependent DNA helicase. Binds DNA in the crystal structure (PDB: 2WWY)	None	5965	RecQ like helicase	2WWY	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2449	ENSG00000164620	RELL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR022248;	285613	RELT like 2 [Source:HGNC Symbol;Acc:HGNC:26902]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000297164#ENSG00000164620#ENST00000297164#Other#RELT$#ENSP00000409443#ENSG00000164620#ENST00000444782#Other#RELT$#ENSP00000427992#ENSG00000164620#ENST00000518856#Other#$#ENSP00000430948#ENSG00000164620#ENST00000521367#Other#	FALSE
2450	ENSG00000189056	RELN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a large secreted extracellular matrix protein	IPR000742;IPR002861;IPR011040;IPR013032	5649	reelin [Source:HGNC Symbol;Acc:HGNC:9957]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000189056#GO:0032793#positive regulation of CREB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000345694#ENSG00000189056#ENST00000343529#Other#BNR, EGF_2, Reeler$#ENSP00000388446#ENSG00000189056#ENST00000424685#Other#BNR, EGF_2, Reeler$#ENSP00000392423#ENSG00000189056#ENST00000428762#Other#BNR, EGF_2, Reeler$#ENSP00000404818#ENSG00000189056#ENST00000429186#Other#	FALSE
2451	ENSG00000135945	REV1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA polymerase. Binds DNA in the crystal structure (PDB: 3GQC)	None	51455	REV1, DNA directed polymerase	3GQC	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2452	ENSG00000148300	REXO4	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	REXO4 (hPMC2) has been shown to bind ERE containing sequences in gel-shift experiments (PMID: 10908561) in complex with ERbeta. However, figures containing the gel-shifts have been cropped to exclude the unshifted free DNA band so it is hard to judge the evidence.	IPR006055;IPR012337;IPR013520	57109	REX4 homolog, 3-5 exonuclease [Source:HGNC Symbol;Acc:HGNC:12820]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000148300#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10908561	$#ENSP00000361010#ENSG00000148300#ENST00000371942#Other#RNase_T$#ENSP00000361003#ENSG00000148300#ENST00000371935#Other#RNase_T$#ENSP00000391534#ENSG00000148300#ENST00000445916#Other#$#ENSP00000394229#ENSG00000148300#ENST00000454825#Other#RNase_T	FALSE
2453	ENSG00000035928	RFC1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA-dependent ATPase. Binds DNA (contact with major groove and backbone) in the crystal structure (PDB: 2K7F)	None	5981	replication factor C subunit 1	2K7F	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2454	ENSG00000064490	RFXANK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	AKA RFX-B.  No DBD, no motifs produced when tested, no evidence of independent DNA binding. (PMID: 9806546) shows that its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters, but it does not bind DNA on its own.	IPR002110;IPR017362;IPR020683;	8625	regulatory factor X associated ankyrin containing protein [Source:HGNC Symbol;Acc:HGNC:9987]	None	DBD and Full	not tested	None	PMID:20637319 shows that RFXANK is a cofactor of RFX-proteins that binds them with PPI and DNA doesnt contribute to the complex formation	other	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:1505028;9806546	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Tim Hughes	Yes	$#ENSG00000064490#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9806546	$#ENSP00000305071#ENSG00000064490#ENST00000303088#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000376138#ENSG00000064490#ENST00000392324#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000384572#ENSG00000064490#ENST00000407360#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000409138#ENSG00000064490#ENST00000456252#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000444280#ENSG00000064490#ENST00000535017#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5$#ENSP00000466913#ENSG00000064490#ENST00000593273#Other#Ank_2, Ank_4, Ank_5	FALSE
2455	ENSG00000133111	RFXAP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included because TF-CAT calls it a cofactor and GO erroneously calls it sequence-specific DNA binding. Based on PMID:20732328 it forms protei-protein interactions with RFX5, unlikely to contribute to Protein-DNA interaction	IPR029316	5994	regulatory factor X associated protein [Source:HGNC Symbol;Acc:HGNC:9988]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11486010	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Laura Campitelli	Yes	$#ENSG00000133111#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9118943	$#ENSP00000255476#ENSG00000133111#ENST00000255476#Other#RFXA_RFXANK_bdg	FALSE
2456	ENSG00000102760	RGCC	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR029252	28984	regulator of cell cycle [Source:HGNC Symbol;Acc:HGNC:20369];Regulator of cell cycle RGCC	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000102760#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19158077	$#ENSP00000368664#ENSG00000102760#ENST00000379359#Other#RGCC	FALSE
2457	ENSG00000076344	RGS11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	None	IPR000591;IPR015898;IPR016137;	8786	regulator of G-protein signaling 11 [Source:HGNC Symbol;Acc:HGNC:9993]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000319069#ENSG00000076344#ENST00000316163#Other#DEP, G-gamma, RGS$#ENSP00000352778#ENSG00000076344#ENST00000359740#Other#DEP, G-gamma, RGS$#ENSP00000380876#ENSG00000076344#ENST00000397770#Other#DEP, G-gamma, RGS	FALSE
2458	ENSG00000182732	RGS6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR015898;IPR016137;	9628	regulator of G-protein signaling 6 [Source:HGNC Symbol;Acc:HGNC:10002]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000347699#ENSG00000182732#ENST00000355512#Other#DEP, G-gamma, RGS$#ENSP00000383953#ENSG00000182732#ENST00000402788#Other#DEP, G-gamma, RGS$#ENSP00000385243#ENSG00000182732#ENST00000404301#Other#DEP, G-gamma, RGS$#ENSP00000384218#ENSG00000182732#ENST00000406236#Other#DEP, G-gamma, RGS$#ENSP00000384612#ENSG00000182732#ENST00000407322#Other#DEP, G-gamma, RGS$#ENSP00000452331#ENSG00000182732#ENST00000553530#Other#DEP, G-gamma, RGS$#ENSP00000451912#ENSG00000182732#ENST00000554782#Other#G-gamma, RGS$#ENSP00000450936#ENSG00000182732#ENST00000555571#Other#DEP, G-gamma, RGS$#ENSP00000451855#ENSG00000182732#ENST00000556437#Other#DEP, G-gamma, RGS$#ENSP00000478186#ENSG00000182732#ENST00000622468#Other#DEP, G-gamma, RGS$#ENSP00000412144#ENSG00000182732#ENST00000434263#Other#DEP, G-gamma, RGS$#ENSP00000451030#ENSG00000182732#ENST00000553525#Other#DEP, G-gamma, RGS	FALSE
2459	ENSG00000182901	RGS7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR015898;IPR016137;	6000	regulator of G-protein signaling 7 [Source:HGNC Symbol;Acc:HGNC:10003]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000341242#ENSG00000182901#ENST00000348120#Other#DEP, G-gamma, RGS, RGS-like$#ENSP00000355522#ENSG00000182901#ENST00000366564#Other#DEP, G-gamma, RGS, RGS-like$#ENSP00000355523#ENSG00000182901#ENST00000366565#Other#DEP, G-gamma, RGS, RGS-like$#ENSP00000404399#ENSG00000182901#ENST00000440928#Other#G-gamma, RGS, RGS-like	FALSE
2460	ENSG00000108370	RGS9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000591;IPR015898;IPR016137;	8787	regulator of G-protein signaling 9 [Source:HGNC Symbol;Acc:HGNC:10004]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$#ENSP00000262406#ENSG00000108370#ENST00000262406#Other#DEP, G-gamma, RGS$#ENSP00000405814#ENSG00000108370#ENST00000443584#Other#DEP, G-gamma, RGS$#ENSP00000396329#ENSG00000108370#ENST00000449996#Other#DEP, G-gamma, RGS$#ENSP00000490658#ENSG00000108370#ENST00000635833#Other#DEP, G-gamma, RGS	FALSE
2461	ENSG00000167550	RHEBL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001806;IPR003578;IPR003579;IPR005225;IPR020849;IPR027417	121268	Ras homolog enriched in brain like 1 [Source:HGNC Symbol;Acc:HGNC:21166];GTPase RhebL1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000167550#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:16328882	$#ENSP00000301068#ENSG00000167550#ENST00000301068#Other#Arf, DUF258, GTP_EFTU, MMR_HSR1, Ras, Roc, SRPRB$#ENSP00000447428#ENSG00000167550#ENST00000550675#Other#Arf, MMR_HSR1, Ras, Roc, SRPRB	FALSE
2462	ENSG00000204227	RING1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	RING1 is a well-characterized member of the Polycomb complex. No reference to DNA-binding in literature search on EntrezGene	IPR001841;IPR017907;IPR018957	6015	ring finger protein 1 [Source:HGNC Symbol;Acc:HGNC:10018]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:9312051;9858531;12482919;14999091	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000204227##Other#	FALSE
2463	ENSG00000058729	RIOK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000687;IPR011009;IPR015285;IPR018934;IPR018935;	55781	RIO kinase 2 [Source:HGNC Symbol;Acc:HGNC:18999]	None	Full	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$#ENSP00000283109#ENSG00000058729#ENST00000283109#Other#APH, Kdo, RIO1, Rio2_N$#ENSP00000420932#ENSG00000058729#ENST00000508447#Other#APH, Kdo, RIO1, Rio2_N$#ENSP00000422772#ENSG00000058729#ENST00000511012#Other#$#ENSP00000421830#ENSG00000058729#ENST00000511293#Other#	FALSE
2464	ENSG00000137275	RIPK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000488;IPR000719;IPR001245;IPR002290;IPR008271;IPR011009;IPR011029;IPR025735	8737	receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	$#ENSG00000137275#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:10521396, PMID:21931591, PMID:8612133	$#ENSP00000369773#ENSG00000137275#ENST00000380409#Other#Death, Kinase-like, Pkinase, Pkinase_Tyr, RHIM$#ENSP00000259808#ENSG00000137275#ENST00000259808#Other#Death, Kinase-like, Pkinase, Pkinase_Tyr, RHIM	FALSE
2465	ENSG00000104312	RIPK2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein activates NFKB through its kinase activity	IPR000719;IPR001315;IPR002290;IPR008271;IPR011009;IPR011029;IPR017322	8767	receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000104312#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21887730, PMID:21931591 | TAS - Reactom	$#ENSP00000220751#ENSG00000104312#ENST00000220751#Other#CARD, Pkinase, Pkinase_Tyr	FALSE
2466	ENSG00000129465	RIPK3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase protein	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441;IPR025735	11035	receptor interacting serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:10021]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000129465#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:21931591	$#ENSP00000216274#ENSG00000129465#ENST00000216274#Other#APH, Pkinase, Pkinase_Tyr, RHIM$#ENSP00000451840#ENSG00000129465#ENST00000554569#Other#RHIM	FALSE
2467	ENSG00000183421	RIPK4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002110;IPR002290;IPR008271;IPR011009;IPR017441;IPR020683	54101	receptor interacting serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:496]	None	not tested	not tested	None	None	No	No	Probably Not a TF - No evidence that it is a TF___PMIDS:0	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000183421#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21931591	$#ENSP00000332454#ENSG00000183421#ENST00000332512#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Pkinase, Pkinase_$#ENSP00000330161#ENSG00000183421#ENST00000352483#Other#Ank, Ank_2, Ank_3, Ank_4, Ank_5, Pkinase, Pkinase_	FALSE
2468	ENSG00000131263	RLIM	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	LIM ZF proteins are unlikely to bind DNA	None	51132	E3 ubiquitin-protein ligase RLIM	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000131263#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000131263##Other#	FALSE
2469	ENSG00000169385	RNASE2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001427;IPR023411;IPR023412;	6036	ribonuclease A family member 2 [Source:HGNC Symbol;Acc:HGNC:10045]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	$#ENSP00000303276#ENSG00000169385#ENST00000304625#Other#RnaseA	FALSE
2470	ENSG00000171865	RNASEH1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Ribonuclease H1. Binds DNA-RNA hybrid in structure (PDB: 2QKB)	None	246243	ribonuclease H1	2QKB	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2471	ENSG00000124226	RNF114	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001841;IPR008598;IPR017907;IPR018957	55905	ring finger protein 114 [Source:HGNC Symbol;Acc:HGNC:13094]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000244061#ENSG00000124226#ENST00000244061#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000485239#ENSG00000124226#ENST00000625177#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000485317#ENSG00000124226#ENST00000622920#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4	FALSE
2472	ENSG00000101695	RNF125	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiguitin ligase	IPR001841;IPR008598;IPR017907;	54941	ring finger protein 125 [Source:HGNC Symbol;Acc:HGNC:21150]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$#ENSP00000217740#ENSG00000101695#ENST00000217740#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4	FALSE
2473	ENSG00000134758	RNF138	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	DNA repair protein. RNF138 is recruited to DNA damage sites through zinc fingers that have a strong preference for DNA with 5- or 3-single-stranded overhangs. (PMID: 26502055)	IPR001841;IPR004181;IPR008598;IPR018957	51444	ring finger protein 138 [Source:HGNC Symbol;Acc:HGNC:17765]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	None	$#ENSP00000261593#ENSG00000134758#ENST00000261593#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-$#ENSP00000257190#ENSG00000134758#ENST00000257190#Other#zf-C2H2_4, zf-C3HC4, zf-C3HC4_2, zf-Di19, zf-MIZ, $#ENSP00000463659#ENSG00000134758#ENST00000577999#Other#zf-Di19$#ENSP00000462498#ENSG00000134758#ENST00000578107#Other#Prok-RING_4, U-box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000463153#ENSG00000134758#ENST00000580499#Other#Prok-RING_4, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-	FALSE
2474	ENSG00000013561	RNF14	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor	IPR001841;IPR002867;IPR006575;IPR016135;IPR017907	9604	ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10085091	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000013561##Other#	FALSE
2475	ENSG00000158717	RNF166	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiquitin ligase (PMID: 26456228)	IPR001841;IPR008598;IPR017907;	115992	ring finger protein 166 [Source:HGNC Symbol;Acc:HGNC:28856]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$#ENSP00000326095#ENSG00000158717#ENST00000312838#Other#Prok-RING_4, Rubredoxin, U-box, UIM, zf-C3HC4, zf-$#ENSP00000446301#ENSG00000158717#ENST00000537718#Other#UIM, zf-Di19, zinc_ribbon_2$#ENSP00000440454#ENSG00000158717#ENST00000541206#Other#UIM, zf-Di19, zinc_ribbon_2$#ENSP00000455617#ENSG00000158717#ENST00000567408#Other#$#ENSP00000457374#ENSG00000158717#ENST00000568683#Other#zf-Di19, zf-ribbon_3, zinc_ribbon_2	FALSE
2476	ENSG00000121481	RNF2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Forms non-specific DNA contacts according to crystal structure (PMID:  25355358)	IPR001841;IPR017907;IPR018957	6045	ring finger protein 2 [Source:HGNC Symbol;Acc:HGNC:10061];E3 ubiquitin-protein ligase RING2	4R8P	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:12183370;16687444	Yes	3a, decent circumstantial evidence for its role as	Sam Lambert	Jussi Taipale	No	$#ENSG00000121481#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:18629613	$#ENSP00000356480#ENSG00000121481#ENST00000367510#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_$#ENSP00000356479#ENSG00000121481#ENST00000367509#Other#RAWUL, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_$#ENSP00000400722#ENSG00000121481#ENST00000453650#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-N	FALSE
2477	ENSG00000163481	RNF25	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Probably a co-regulator; no clear evidence for direct binding to DNA	IPR001841;IPR006575;IPR016135	64320	ring finger protein 25 [Source:HGNC Symbol;Acc:HGNC:14662];E3 ubiquitin-protein ligase RNF25	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:12748188	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000163481#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12748188	$#ENSP00000295704#ENSG00000163481#ENST00000295704#Other#RWD, zf-RING_11, zf-RING_2	FALSE
2478	ENSG00000092098	RNF31	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001876;IPR002867;IPR015940;IPR017907;IPR018997	55072	ring finger protein 31 [Source:HGNC Symbol;Acc:HGNC:16031];E3 ubiquitin-protein ligase RNF31	None	Full	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000092098#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:19136968	$#ENSP00000315112#ENSG00000092098#ENST00000324103#Other#HOIP-UBA, IBR, PUB, zf-RanBP$#ENSP00000453574#ENSG00000092098#ENST00000559275#Other#HOIP-UBA, IBR, NMD3, zf-RanBP$#ENSP00000452972#ENSG00000092098#ENST00000560787#Other#HOIP-UBA, IBR, PUB, zf-RanBP$#ENSP00000452820#ENSG00000092098#ENST00000559719#Other#IBR$#ENSP00000453501#ENSG00000092098#ENST00000560754#Other#IBR	FALSE
2479	ENSG00000063978	RNF4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiquitin ligase (PMID: 18408734)	IPR001841;IPR017907	6047	ring finger protein 4 [Source:HGNC Symbol;Acc:HGNC:10067]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:9710597	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000063978#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9710597	$#ENSP00000315212#ENSG00000063978#ENST00000314289#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC$#ENSP00000424076#ENSG00000063978#ENST00000506706#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC$#ENSP00000422728#ENSG00000063978#ENST00000507247#Other#$#ENSP00000422500#ENSG00000063978#ENST00000509258#Other#$#ENSP00000426615#ENSG00000063978#ENST00000511859#Other#$#ENSP00000446369#ENSG00000063978#ENST00000541204#Other#$#ENSP00000423100#ENSG00000063978#ENST00000502316#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC$#ENSP00000426503#ENSG00000063978#ENST00000511600#Other#Prok-RING_4, Rtf2, Zn_ribbon_17, zf-C3HC4, zf-C3HC	FALSE
2480	ENSG00000181852	RNF41	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiquitin ligase	None	10193	E3 ubiquitin-protein ligase NRDP1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000181852#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000181852##Other#	FALSE
2481	ENSG00000117748	RPA2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR004365;IPR012340;IPR014646;IPR014892	6118	replication protein A2 [Source:HGNC Symbol;Acc:HGNC:10290]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$#ENSP00000363015#ENSG00000117748#ENST00000313433#Other#RPA_C, tRNA_anti-codon$#ENSP00000363021#ENSG00000117748#ENST00000373912#Other#RPA_C, tRNA_anti-codon$#ENSP00000363017#ENSG00000117748#ENST00000373909#Other#RPA_C, tRNA_anti-codon$#ENSP00000413541#ENSG00000117748#ENST00000419958#Other#RPA_C	FALSE
2482	ENSG00000204086	RPA4	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	ssDNA binding protein involved in DNA repair (PMID: 7760808)	IPR004365;IPR012340;IPR014646;IPR014892	29935	replication protein A4 [Source:HGNC Symbol;Acc:HGNC:30305]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000362131#ENSG00000204086#ENST00000373040#Other#RPA_C, tRNA_anti-codon	FALSE
2483	ENSG00000147604	RPL7	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA by filter binding (PMID: 8441630), but competition assays suggest it is non-specific.  A specific dsRNA structure is thought to be the preferred substrate.  RNA-binding has been demonstrated by gel-shift experiments (PMID: 10329420).	IPR005998;IPR012988;IPR016082;IPR018038	6129	ribosomal protein L7 [Source:HGNC Symbol;Acc:HGNC:10363]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7568167	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000147604##Other#	FALSE
2484	ENSG00000148303	RPL7A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001921;IPR004037;IPR004038;IPR018492;IPR029064	6130	ribosomal protein L7a [Source:HGNC Symbol;Acc:HGNC:10364]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7568167	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$##ENSG00000148303##Other#	FALSE
2485	ENSG00000143947	RPS27A	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000626;IPR002906;IPR011332;IPR019954;IPR019956;IPR029071	6233	ribosomal protein S27a [Source:HGNC Symbol;Acc:HGNC:10417]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000143947#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000272317#ENSG00000143947#ENST00000272317#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ribosomal_S27, Ub$#ENSP00000385659#ENSG00000143947#ENST00000404735#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ribosomal_S27, Ub$#ENSP00000383981#ENSG00000143947#ENST00000402285#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ribosomal_S27, Ub$#ENSP00000408482#ENSG00000143947#ENST00000449323#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiq	FALSE
2486	ENSG00000162302	RPS6KA4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR000961;IPR002290;IPR008271;IPR011009;IPR016239;IPR017441;IPR017892	8986	ribosomal protein S6 kinase A4 [Source:HGNC Symbol;Acc:HGNC:10433]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000162302#GO:0032793#positive regulation of CREB transcription factor activity#TAS - PMID:18508628$#ENSG00000162302#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18508628	$#ENSP00000333896#ENSG00000162302#ENST00000334205#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000435580#ENSG00000162302#ENST00000528057#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000432945#ENSG00000162302#ENST00000530504#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P	FALSE
2487	ENSG00000100784	RPS6KA5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD - its a kinase.  Included only because GO says its an upstream regulator of CREB and NF-kappaB	IPR000719;IPR000961;IPR002290;IPR008271;IPR011009;IPR016239;IPR017441;IPR017892	9252	ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	$#ENSG00000100784#GO:0032793#positive regulation of CREB transcription factor activity#TAS - PMID:18508628$#ENSG00000100784#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12628924, PMID:18511904	$#ENSP00000402787#ENSG00000100784#ENST00000418736#Other#APH, FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, P$#ENSP00000479667#ENSG00000100784#ENST00000614987#Other#APH, Choline_kinase, FTA2, Kdo, Kinase-like, Pkina$#ENSP00000442803#ENSG00000100784#ENST00000536315#Other#APH, Choline_kinase, FTA2, Kdo, Kinase-like, Pkina	FALSE
2488	ENSG00000085721	RRN3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR007991	54700	RRN3 homolog, RNA polymerase I transcription factor [Source:HGNC Symbol;Acc:HGNC:30346]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8670901;10758157;11250903	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$##ENSG00000085721##Other#	FALSE
2489	ENSG00000079102	RUNX1T1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002893;IPR003894;IPR013289;IPR013290;IPR014896	862	RUNX1 translocation partner 1 [Source:HGNC Symbol;Acc:HGNC:1535]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9724795;9819404	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000079102#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000353504#ENSG00000079102#ENST00000360348#Other#NHR2, TAFH, zf-MYND$#ENSP00000379520#ENSG00000079102#ENST00000396218#Other#NHR2, TAFH, zf-MYND$#ENSP00000390137#ENSG00000079102#ENST00000422361#Other#NHR2, TAFH, zf-MYND$#ENSP00000430728#ENSG00000079102#ENST00000518844#Other#NHR2, TAFH, zf-MYND$#ENSP00000429728#ENSG00000079102#ENST00000521553#Other#TAFH$#ENSP00000428742#ENSG00000079102#ENST00000520724#Other#DUF3731, NHR2, TAFH, zf-MYND$#ENSP00000429666#ENSG00000079102#ENST00000521375#Other#	FALSE
2490	ENSG00000122481	RWDD3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included because GO says negative regulation of NF-kappaB transcription factor activity.  No DBD, no motif, etc	IPR006575;IPR016135	25950	RWD domain containing 3 [Source:HGNC Symbol;Acc:HGNC:21393]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000122481#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:23469069	$#ENSP00000263893#ENSG00000122481#ENST00000263893#Other#RWD$#ENSP00000359221#ENSG00000122481#ENST00000370202#Other#DUF1115, RWD	FALSE
2491	ENSG00000163602	RYBP	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains RanBP ZFs, so likely an RNA-binding protein	IPR001876	23429	RING1 and YY1 binding protein	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10369680;12411495	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	None	$##ENSG00000163602##Other#	FALSE
2492	ENSG00000163221	S100A12	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001751;IPR002048;IPR013787	6283	S100 calcium binding protein A12 [Source:HGNC Symbol;Acc:HGNC:10489]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000163221#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18443896	$#ENSP00000357726#ENSG00000163221#ENST00000368737#Other#EF-hand_1, EF-hand_6, EF-hand_7, EF-hand_8, S_100	FALSE
2493	ENSG00000143546	S100A8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001751;IPR002048;IPR013787;IPR018247	6279	S100 calcium binding protein A8 [Source:HGNC Symbol;Acc:HGNC:10498]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000143546#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:22489132	$#ENSP00000357722#ENSG00000143546#ENST00000368733#Other#EF-hand_1, EF-hand_5, EF-hand_7, EF-hand_8, S_100$#ENSP00000357721#ENSG00000143546#ENST00000368732#Other#EF-hand_1, EF-hand_5, EF-hand_7, EF-hand_8, S_100	FALSE
2494	ENSG00000163220	S100A9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001751;IPR002048;IPR013787;IPR018247	6280	S100 calcium binding protein A9 [Source:HGNC Symbol;Acc:HGNC:10499]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000163220#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:22489132	$#ENSP00000357727#ENSG00000163220#ENST00000368738#Other#EF-hand_1, EF-hand_4, EF-hand_7, EF-hand_8, S_100	FALSE
2495	ENSG00000160633	SAFB	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Based on this review the protein is likely to bind AT-rich DNA in a non-sequence specific manner (PMID: 27888239)	IPR000504;IPR003034	6294	scaffold attachment factor B [Source:HGNC Symbol;Acc:HGNC:10520]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15066997	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000160633##Other#	FALSE
2496	ENSG00000130254	SAFB2	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Bind AT-rich DNA elements and RNA (PMID: 27888239)	IPR000504;IPR003034	9667	scaffold attachment factor B2 [Source:HGNC Symbol;Acc:HGNC:21605]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:12660241	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$##ENSG00000130254##Other#	FALSE
2497	ENSG00000151748	SAV1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	60485	Protein salvador homolog 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000151748#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000151748##Other#	FALSE
2498	ENSG00000171222	SCAND1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003309;IPR008916	51282	SCAN domain containing 1 [Source:HGNC Symbol;Acc:HGNC:10566]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	$#ENSG00000171222#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000301995#ENSG00000171222#ENST00000305978#Other#SCAN$#ENSP00000363103#ENSG00000171222#ENST00000373991#Other#SCAN$#ENSP00000481289#ENSG00000171222#ENST00000615116#Other#SCAN	FALSE
2499	ENSG00000176700	SCAND2P	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	None	None	Has no Entrez identifier	Putative SCAN domain-containing protein SCAND2P	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000176700#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000176700##Other#	FALSE
2500	ENSG00000140386	SCAPER	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Involved in cell cycle regulation in the cytoplasm (PMID: 17698606)	IPR003604;	49855	S-phase cyclin A associated protein in the ER [Source:HGNC Symbol;Acc:HGNC:13081]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000326924#ENSG00000140386#ENST00000324767#Other#SCAPER_N, zf-met$#ENSP00000442190#ENSG00000140386#ENST00000538941#Other#zf-met$#ENSP00000456508#ENSG00000140386#ENST00000564590#Other#SCAPER_N$#ENSP00000456987#ENSG00000140386#ENST00000564022#Other#	FALSE
2501	ENSG00000010803	SCMH1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Has a SLED domain (IPR021987). (PMID: 24727478) claims, based on NMR, that SLED is a sequence-specific DBD with relatively high specificity	IPR001660;IPR004092;IPR013761;IPR021129;IPR021987	22955	sex comb on midleg homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19003];Polycomb protein SCMH1	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Other_PMIDS:10653359	Yes	4a, two or more datasets predict it as a TF	Tim Hughes	Jussi Taipale	No	$#ENSG00000010803#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10524249	$#ENSP00000318094#ENSG00000010803#ENST00000326197#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000354656#ENSG00000010803#ENST00000361191#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000354996#ENSG00000010803#ENST00000361705#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000361676#ENSG00000010803#ENST00000372595#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000361677#ENSG00000010803#ENST00000372596#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000361678#ENSG00000010803#ENST00000372597#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000380356#ENSG00000010803#ENST00000397171#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000337352#ENSG00000010803#ENST00000337495#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000380359#ENSG00000010803#ENST00000397174#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000403974#ENSG00000010803#ENST00000456518#Other#MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED$#ENSP00000479881#ENSG00000010803#ENST00000472037#Other#SAM_1, SAM_2, SAM_PNT	FALSE
2502	ENSG00000047634	SCML1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Homologous to polycomb proteins, so likely a transcriptional cofactor (PMID: 9570953). Has putative roles in the testis development and spermatogenesis (PMID:18601738). Reference cited by GO provides no evidence of DNA-binding activity (PMID: 9570953).	IPR001660;IPR013761;IPR021129	6322	sex comb on midleg-like 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10580]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	$#ENSG00000047634#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9570953	$#ENSP00000369382#ENSG00000047634#ENST00000380043#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000369384#ENSG00000047634#ENST00000380045#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000381154#ENSG00000047634#ENST00000398080#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000392587#ENSG00000047634#ENST00000419185#Other#	FALSE
2503	ENSG00000102098	SCML2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Part of the polycomb repressor complex that functions in male, establishing the male germline epigenome through regulation of histone H2A ubiquitination (PMID: 25703348)	IPR001660;IPR004092;IPR013761;IPR021129;IPR021987	10389	sex comb on midleg-like 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10581]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:12952983;15280237	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Yimeng Yin	No	$#ENSG00000102098#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10331946	$#ENSP00000251900#ENSG00000102098#ENST00000251900#Other#MBT, RBR, SAM_1, SAM_PNT, SLED$#ENSP00000381126#ENSG00000102098#ENST00000398048#Other#SAM_1, SAM_2, SAM_PNT$#ENSP00000407315#ENSG00000102098#ENST00000420857#Other#	FALSE
2504	ENSG00000196189	SEMA4A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001627;IPR002165;IPR016201;	64218	semaphorin 4A [Source:HGNC Symbol;Acc:HGNC:10729]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000347117#ENSG00000196189#ENST00000355014#Other#PSI, Sema$#ENSP00000357265#ENSG00000196189#ENST00000368282#Other#PSI, Sema$#ENSP00000357268#ENSG00000196189#ENST00000368285#Other#PSI, Sema$#ENSP00000357267#ENSG00000196189#ENST00000368284#Other#PSI, Sema	FALSE
2505	ENSG00000197019	SERTAD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-factor; no evidence for DNA-binding activity	IPR009263	29950	SERTA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:17932]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Transactivation_PMIDS:11331592;16098148	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000197019##Other#	FALSE
2506	ENSG00000179833	SERTAD2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor that associates with E2F/TFDP heterodimers (PMID: 19152710). Does not contain any DBDs	IPR009263	9792	SERTA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30784]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16098148	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$##ENSG00000179833##Other#	FALSE
2507	ENSG00000103037	SETD6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Methyltransferase to the NF-kappaB complex (PMID: 21131967) and histones (PMID: 23324626)	IPR001214;IPR011383;IPR015353	79918	SET domain containing 6 [Source:HGNC Symbol;Acc:HGNC:26116];N-lysine methyltransferase SETD6	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	$#ENSG00000103037#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:21131967	$#ENSP00000219315#ENSG00000103037#ENST00000219315#Other#Rubis-subs-bind, SET$#ENSP00000310082#ENSG00000103037#ENST00000310682#Other#Rubis-subs-bind, SET$#ENSP00000377809#ENSG00000103037#ENST00000394266#Other#Rubis-subs-bind, SET$#ENSP00000396437#ENSG00000103037#ENST00000447443#Other#Rubis-subs-bind	FALSE
2508	ENSG00000104897	SF3A2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Functions in splicing	IPR000690;IPR003604;IPR019134;	8175	splicing factor 3a subunit 2 [Source:HGNC Symbol;Acc:HGNC:10766]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	None	$#ENSP00000221494#ENSG00000104897#ENST00000221494#Other#CactinC_cactus, SF3A2, zf-met$#ENSP00000466634#ENSG00000104897#ENST00000586396#Other#SF3A2, zf-met	FALSE
2509	ENSG00000183431	SF3A3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	RNA-binding protein	IPR000690;IPR021966;IPR024598;	10946	splicing factor 3a subunit 3 [Source:HGNC Symbol;Acc:HGNC:10767]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000362110#ENSG00000183431#ENST00000373019#Other#DUF3449, SF3A3, SF3a60_bindingd, Telomere_Sde2_2	FALSE
2510	ENSG00000116560	SFPQ	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Splicing factor - contains 2 RRM domains	None	6421	splicing factor proline and glutamine rich [Source:HGNC Symbol;Acc:HGNC:10774]	None	not tested	not tested	None	None	No	No	No	No	2a1, Lower confidence direct evidence	Yimeng Yin	Sam Lambert	Yes	None	$##ENSG00000116560##Other#	FALSE
2511	ENSG00000106483	SFRP4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001134;IPR008993;IPR018933;IPR020067	6424	secreted frizzled related protein 4 [Source:HGNC Symbol;Acc:HGNC:10778]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000106483#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18945944	$#ENSP00000410715#ENSG00000106483#ENST00000436072#Other#Fz, NTR$#ENSP00000402262#ENSG00000106483#ENST00000447200#Other#NTR	FALSE
2512	ENSG00000120057	SFRP5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001134;IPR008993;IPR018933;IPR020067	6425	secreted frizzled related protein 5 [Source:HGNC Symbol;Acc:HGNC:10779]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000120057#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:19957335	$#ENSP00000266066#ENSG00000120057#ENST00000266066#Other#Fz, NTR	FALSE
2513	ENSG00000168878	SFTPB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003119;IPR007856;IPR008138;IPR008139;IPR008373;IPR011001	6439	surfactant protein B [Source:HGNC Symbol;Acc:HGNC:10801]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000428719#ENSG00000168878#ENST00000519937#Other#SapA, SapB_1, SapB_2$#ENSP00000415347#ENSG00000168878#ENST00000428225#Other#SapA, SapB_1, SapB_2$#ENSP00000476194#ENSG00000168878#ENST00000494165#Other#SapB_2	FALSE
2514	ENSG00000118515	SGK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR000961;IPR001683;IPR002290;IPR008271;IPR011009;IPR017441;IPR017892	6446	serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol;Acc:HGNC:10810]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	$#ENSG00000118515#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:20530112	$#ENSP00000237305#ENSG00000118515#ENST00000237305#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000356831#ENSG00000118515#ENST00000367857#Other#FTA2, Kdo, Kinase-like, PX, Pkinase, Pkinase_C, Pk$#ENSP00000356832#ENSG00000118515#ENST00000367858#Other#FTA2, Kdo, Kinase-like, PX, Pkinase, Pkinase_C, Pk$#ENSP00000396242#ENSG00000118515#ENST00000413996#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000435724#ENSG00000118515#ENST00000524929#Other#$#ENSP00000434450#ENSG00000118515#ENST00000528577#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000434302#ENSG00000118515#ENST00000475719#Other#FTA2, Kdo, Kinase-like, Pkinase, Pkinase_C, Pkinas$#ENSP00000431705#ENSG00000118515#ENST00000460769#Other#	FALSE
2515	ENSG00000104205	SGK3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein kinase that operates upstream in the signaling cascade	IPR000719;IPR000961;IPR001683;IPR002290;IPR008271;IPR011009;IPR017441;IPR017892	23678	serum/glucocorticoid regulated kinase family member 3 [Source:HGNC Symbol;Acc:HGNC:10812]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	$#ENSG00000104205#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:20919962	$#ENSP00000331816#ENSG00000104205#ENST00000345714#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000379842#ENSG00000104205#ENST00000396596#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000430463#ENSG00000104205#ENST00000521198#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000430691#ENSG00000104205#ENST00000520976#Other#FTA2, Kinase-like, PX, Pkinase, Pkinase_C, Pkinase$#ENSP00000428529#ENSG00000104205#ENST00000519396#Other#Pkinase, Pkinase_Tyr$#ENSP00000429565#ENSG00000104205#ENST00000521152#Other#PX, Pkinase, Pkinase_Tyr$#ENSP00000429606#ENSG00000104205#ENST00000522629#Other#PX	FALSE
2516	ENSG00000164690	SHH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000320;IPR001657;IPR001767;IPR003586;IPR003587;IPR006141;IPR009045;IPR028992	6469	sonic hedgehog [Source:HGNC Symbol;Acc:HGNC:10848]	None	not tested	not tested	None	None	No	No	Probably Not a TF - No evidence that it is a TF___PMIDS:0	Yes	3a, decent circumstantial evidence for its role as	Yimeng Yin	Pratyush Das	No	$#ENSG00000164690#GO:0007228#positive regulation of hh target transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000297261#ENSG00000164690#ENST00000297261#Other#HH_signal, Hint, Peptidase_M15_3$#ENSP00000396621#ENSG00000164690#ENST00000430104#Other#HH_signal, Peptidase_M15_3	FALSE
2517	ENSG00000146414	SHPRH	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000330;IPR001650;IPR001841;IPR001965;IPR005818;IPR011011;IPR014001;IPR017907;IPR019786;IPR019787;IPR027417;	257218	SNF2 histone linker PHD RING helicase [Source:HGNC Symbol;Acc:HGNC:19336]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000275233#ENSG00000146414#ENST00000275233#Other#Helicase_C, Linker_histone, PHD, SNF2_N, zf-C3HC4,$#ENSP00000412797#ENSG00000146414#ENST00000438092#Other#Helicase_C, Linker_histone, PHD, SNF2_N, zf-C3HC4,$#ENSP00000403790#ENSG00000146414#ENST00000417762#Other#Helicase_C	FALSE
2518	ENSG00000185187	SIGIRR	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000157;IPR007110	59307	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [Source:HGNC Symbol;Acc:HGNC:3057	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	$#ENSG00000185187#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12925853	$#ENSP00000380756#ENSG00000185187#ENST00000397632#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000403104#ENSG00000185187#ENST00000431843#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000333656#ENSG00000185187#ENST00000332725#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000433530#ENSG00000185187#ENST00000526395#Other#$#ENSP00000434164#ENSG00000185187#ENST00000528845#Other#$#ENSP00000433022#ENSG00000185187#ENST00000531205#Other#Ig_2, Ig_3, TIR, TIR_2$#ENSP00000435135#ENSG00000185187#ENST00000528209#Other#TIR, TIR_2$#ENSP00000434030#ENSG00000185187#ENST00000530494#Other#Ig_2	FALSE
2519	ENSG00000142178	SIK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR008271;IPR011009;IPR015940;IPR017090;IPR017441	150094	salt inducible kinase 1 [Source:HGNC Symbol;Acc:HGNC:11142]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000142178#GO:0032792#negative regulation of CREB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000270162#ENSG00000142178#ENST00000270162#Other#Kinase-like, Pkinase, Pkinase_Tyr	FALSE
2520	ENSG00000169375	SIN3A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Motifs are suspect and probably reflect DNA binding specificities of SIN3 contacted TFs. SIN3 does not have any DBDs and is thought to function as a scaffold protein that connects TFs to HDAC complexes. Reviewed in (PMID: 19505602)	IPR003822;IPR013194	25942	SIN3 transcription regulator family member A [Source:HGNC Symbol;Acc:HGNC:19353]	None	not tested	not tested	None	None	No	Yes	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7889570;12091390	No	2a1, Lower confidence direct evidence	Sam Lambert	Arttu Jolma	No	$#ENSG00000169375#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$#ENSP00000353622#ENSG00000169375#ENST00000360439#Other#PAH, Sin3_corepress, Sin3a_C$#ENSP00000378402#ENSG00000169375#ENST00000394947#Other#PAH, Sin3_corepress, Sin3a_C$#ENSP00000378403#ENSG00000169375#ENST00000394949#Other#PAH, Sin3_corepress, Sin3a_C$#ENSP00000455204#ENSG00000169375#ENST00000564778#Other#PAH$#ENSP00000455834#ENSG00000169375#ENST00000567289#Other#	FALSE
2521	ENSG00000127511	SIN3B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Can be tethered to DNA by Mad-Max, but does not appear to have any specificity (PMID: 7889570)	IPR003822;IPR013194	23309	SIN3 transcription regulator family member B [Source:HGNC Symbol;Acc:HGNC:19354]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15935060	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$##ENSG00000127511##Other#	FALSE
2522	ENSG00000096717	SIRT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003000;IPR026590;IPR029035	23411	sirtuin 1 [Source:HGNC Symbol;Acc:HGNC:14929];NAD-dependent protein deacetylase sirtuin-1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000096717#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:15152190$#ENSG00000096717#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11672523, PMID:20955178 | IMP - PMID:17	$#ENSP00000212015#ENSG00000096717#ENST00000212015#Other#DUF592, SIR2, TPP_enzyme_M$#ENSP00000384063#ENSG00000096717#ENST00000403579#Other#SIR2$#ENSP00000384508#ENSG00000096717#ENST00000406900#Other#SIR2$#ENSP00000409208#ENSG00000096717#ENST00000432464#Other#SIR2	FALSE
2523	ENSG00000068903	SIRT2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003000;IPR017328;IPR026590;IPR029035	22933	sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$##ENSG00000068903##Other#	FALSE
2524	ENSG00000142082	SIRT3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a histone de-acetylase	IPR003000;IPR017328;IPR026590;IPR029035	23410	sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:15676284	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$##ENSG00000142082##Other#	FALSE
2525	ENSG00000077463	SIRT6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	No canonical DBD, but it does bind at least one sequence-specific DNA binding protein (TRF2).  Seems more likely to be a cofactor.	IPR003000;IPR026590;IPR029035	51548	sirtuin 6 [Source:HGNC Symbol;Acc:HGNC:14934]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Tim Hughes	Pratyush Das	No	None	$#ENSP00000305310#ENSG00000077463#ENST00000305232#Other#SIR2, TPP_enzyme_M$#ENSP00000337332#ENSG00000077463#ENST00000337491#Other#SIR2, TPP_enzyme_M$#ENSP00000469001#ENSG00000077463#ENST00000601488#Other#SIR2$#ENSP00000471837#ENSG00000077463#ENST00000601571#Other#SIR2$#ENSP00000472023#ENSG00000077463#ENST00000594279#Other#SIR2$#ENSP00000470215#ENSG00000077463#ENST00000597896#Other#SIR2, TPP_enzyme_M	FALSE
2526	ENSG00000184990	SIVA1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Affects transcription through interactions with NF-kappaB  (PMID: 16491128)	IPR006058;IPR022773	10572	SIVA1 apoptosis inducing factor [Source:HGNC Symbol;Acc:HGNC:17712];Apoptosis regulatory protein Siv	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000329213#ENSG00000184990#ENST00000329967#Other#Siva$#ENSP00000329447#ENSG00000184990#ENST00000347067#Other#Siva$#ENSP00000485991#ENSG00000184990#ENST00000535554#Other#Siva$#ENSP00000451570#ENSG00000184990#ENST00000553810#Other#Siva$#ENSP00000451823#ENSG00000184990#ENST00000556195#Other#Siva	FALSE
2527	ENSG00000157933	SKI	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Conflicting evidence.  Binds specifically to GTCTAGAC via EMSA in one study (PMID: 9452486). But, needs to form complexes with other proteins, such as NFI, to bind to DNA in another (PMID: 9380514). Related to SKIL, which also has evidence for DNA binding (PMID: 9824161)	IPR003380;IPR009061;IPR010919;IPR014890	6497	SKI proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10896]	None	DBD	not tested	None	None	a	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12435627	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000157933#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000367797#ENSG00000157933#ENST00000378536#Other#Ski_Sno, c-SKI_SMAD_bind	FALSE
2528	ENSG00000180592	SKIDA1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003380;IPR009061;IPR027971;	387640	SKI/DACH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:32697]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000410041#ENSG00000180592#ENST00000449193#Other#DUF4584, Ski_Sno$#ENSP00000442432#ENSG00000180592#ENST00000444772#Other#DUF4584, Ski_Sno	FALSE
2529	ENSG00000136603	SKIL	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Homodimerizes on GTCTAGAC sequence (EMSA) (PMID: 9824161)	IPR003380;IPR009061;IPR010919;IPR014890	6498	SKI-like proto-oncogene [Source:HGNC Symbol;Acc:HGNC:10897]	None	DBD and Full	not tested	None	None	a	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:9824161;9927733;10531062	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000136603#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:10531062	$#ENSP00000259119#ENSG00000136603#ENST00000259119#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000400193#ENSG00000136603#ENST00000413427#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000415243#ENSG00000136603#ENST00000458537#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000406520#ENSG00000136603#ENST00000426052#Other#Ski_Sno, c-SKI_SMAD_bind	FALSE
2530	ENSG00000188779	SKOR1	Unknown	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None	IPR003380;IPR009061;IPR010919;IPR014890	390598	SKI family transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:21326]	None	DBD	not tested	None	None	a	No	No	Yes	1a1, Direct HQ evidence	Pratyush Das	Arttu Jolma	No	$#ENSG00000188779#GO:0001078#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$#ENSP00000343200#ENSG00000188779#ENST00000341418#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000369374#ENSG00000188779#ENST00000380035#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000452361#ENSG00000188779#ENST00000554054#Other#Ski_Sno, c-SKI_SMAD_bind$#ENSP00000451193#ENSG00000188779#ENST00000554240#Other#Ski_Sno, c-SKI_SMAD_bind	FALSE
2531	ENSG00000197208	SLC22A4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a transmembrane protein of the plasmamembrane	IPR004749;IPR005828;IPR005829;IPR020846	6583	solute carrier family 22 member 4 [Source:HGNC Symbol;Acc:HGNC:10968]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000200652#ENSG00000197208#ENST00000200652#Other#MFS_1, Sugar_tr	FALSE
2532	ENSG00000135502	SLC26A10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002645;IPR011547;IPR030402;	65012	solute carrier family 26 member 10 [Source:HGNC Symbol;Acc:HGNC:14470]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	None	$#ENSP00000320217#ENSG00000135502#ENST00000320442#Other#STAS, Sulfate_transp$#ENSP00000490604#ENSG00000135502#ENST00000637859#Other#Sulfate_transp	FALSE
2533	ENSG00000091138	SLC26A3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included as a candidate only because GO cites a 1993 paper where sequence analysis identified a homeodomain.  But, there seems to be no homeodomain.	IPR001902;IPR002645;IPR011547;IPR018045;IPR030402	1811	solute carrier family 26 member 3 [Source:HGNC Symbol;Acc:HGNC:3018];Chloride anion exchanger	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000091138#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7683425	$#ENSP00000345873#ENSG00000091138#ENST00000340010#Other#STAS, Sulfate_transp$#ENSP00000395955#ENSG00000091138#ENST00000453332#Other#Sulfate_transp	FALSE
2534	ENSG00000014824	SLC30A9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002524;IPR009061	10463	solute carrier family 30 member 9 [Source:HGNC Symbol;Acc:HGNC:1329]	None	not tested	not tested	None	None	c	No	No	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Laura Campitelli	No	$#ENSG00000014824#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:10409434	$#ENSP00000264451#ENSG00000014824#ENST00000264451#Other#Cation_efflux, XPA_C	FALSE
2535	ENSG00000196950	SLC39A10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003689;	57181	solute carrier family 39 member 10 [Source:HGNC Symbol;Acc:HGNC:20861]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000352655#ENSG00000196950#ENST00000359634#Other#Zip$#ENSP00000386766#ENSG00000196950#ENST00000409086#Other#Zip$#ENSP00000406590#ENSG00000196950#ENST00000412905#Other#	FALSE
2536	ENSG00000144290	SLC4A10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003020;IPR003024;IPR011531;IPR013769;IPR016152;	57282	solute carrier family 4 member 10 [Source:HGNC Symbol;Acc:HGNC:13811]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000395797#ENSG00000144290#ENST00000415876#Other#Band_3_cyto, HCO3_cotransp$#ENSP00000393066#ENSG00000144290#ENST00000446997#Other#Band_3_cyto, HCO3_cotransp$#ENSP00000364664#ENSG00000144290#ENST00000375514#Other#Band_3_cyto, HCO3_cotransp	FALSE
2537	ENSG00000080503	SMARCA2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	No clear DBD, and its a known cofactor	IPR000330;IPR001487;IPR001650;IPR006576;IPR013999;IPR014001;IPR014012;IPR014978;IPR018359;IPR027417;IPR029295	6595	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [S	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8223438;8895581	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$##ENSG00000080503##Other#	FALSE
2538	ENSG00000127616	SMARCA4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	(PMID: 24752179) shows via ChIP that it has DNA mediated regulatory activity, but unknown if this is direct or indirect binding.  No clear DBD present in the protein.	IPR000330;IPR001487;IPR001650;IPR006576;IPR013999;IPR014001;IPR014012;IPR014978;IPR018359;IPR027417;IPR029295	6597	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [S	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:12244326	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000127616#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11950834, PMID:17938176	$#ENSP00000343896#ENSG00000127616#ENST00000344626#Other#BRK, Bromodomain, DEAD, HSA, Helicase_C, QLQ, ResI$#ENSP00000395654#ENSG00000127616#ENST00000429416#Other#BRK, Bromodomain, DEAD, HSA, Helicase_C, QLQ, ResI$#ENSP00000467200#ENSG00000127616#ENST00000592158#Other#Helicase_C, SnAC	FALSE
2539	ENSG00000138375	SMARCAL1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Is a DNA binding helicase	IPR000330;IPR001650;IPR010003;IPR014001;IPR027417	50485	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 [Sour	None	not tested	not tested	None	None	No	No	TF Gene Candidate__DNA Binding_PMIDS:10857751	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$##ENSG00000138375##Other#	FALSE
2540	ENSG00000099956	SMARCB1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Alias INI1 is a minor groove DNA-binding protein (PMID: 19398554)	IPR006939;IPR017393	6598	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [S	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:16267391	Yes	4a, two or more datasets predict it as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000099956#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:11950834	$#ENSP00000263121#ENSG00000099956#ENST00000263121#Other#DUF1679, SNF5$#ENSP00000383984#ENSG00000099956#ENST00000407422#Other#DUF1679, SNF5$#ENSP00000489445#ENSG00000099956#ENST00000634926#Other#$#ENSP00000489115#ENSG00000099956#ENST00000635578#Other#$#ENSP00000340883#ENSG00000099956#ENST00000344921#Other#DUF1679, SNF5$#ENSP00000388489#ENSG00000099956#ENST00000417137#Other#SNF5	FALSE
2541	ENSG00000066117	SMARCD1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	It is an active ATP-utilizing chromatin remodeling protein (PMID: 25818293)	IPR003121;IPR019835	6602	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 [S	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:8804307;15525990	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$##ENSG00000066117##Other#	FALSE
2542	ENSG00000108604	SMARCD2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Transcriptional cofactor (PMID: 8804307)	IPR003121;IPR019835	6603	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [S	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:8804307;9427560	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	None	$##ENSG00000108604##Other#	FALSE
2543	ENSG00000082014	SMARCD3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Chromatin remodelling complex component	IPR003121;IPR019835	6604	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 [S	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14701856;15525990	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000082014##Other#	FALSE
2544	ENSG00000108055	SMC3	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds and compacts DNA as a SMC1-SMC3 heterodimer that is part of the cohesin complex (PMID: 23620281). Transfac motifs likely reflect the binding of other TFs such as CTCF that associate with cohesin	IPR003395;IPR010935;IPR027417	9126	structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:HGNC:2468]	None	not tested	not tested	None	None	No	Yes	No	No	2a1, Lower confidence direct evidence	Arttu Jolma	Yimeng Yin	No	None	$#ENSP00000354720#ENSG00000108055#ENST00000361804#Other#AAA_15, AAA_21, AAA_23, AAA_29, SMC_N, SMC_hinge	FALSE
2545	ENSG00000128602	SMO	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The protein is a G-protein coupled receptor	IPR000539;IPR017981;IPR020067	6608	smoothened, frizzled class receptor [Source:HGNC Symbol;Acc:HGNC:11119]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000128602#GO:0007228#positive regulation of hh target transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000249373#ENSG00000128602#ENST00000249373#Other#Dicty_CAR, Frizzled, Fz	FALSE
2546	ENSG00000123415	SMUG1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Involved in DNA mismatch repair. Xenopus homolog binds dsDNA in the crystal structure (PDB: 1OE4)	None	23583	single-strand-selective monofunctional uracil-DNA glycosylase 1	1OE4	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2547	ENSG00000115593	SMYD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001214;IPR002893	150572	SET and MYND domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20986]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:11923873;12011100	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	None	$##ENSG00000115593##Other#	FALSE
2548	ENSG00000185420	SMYD3	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds GGAGGG elements based on SELEX performed using GST fusion protein (PMID: 15235609)	IPR001214;IPR002893;IPR025805	64754	SET and MYND domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15513]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI; Transactivation_PMIDS:15235609;15303093;16155568	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$##ENSG00000185420##Other#	FALSE
2549	ENSG00000104976	SNAPC2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Recognizes the PSE-element, which is located in the core promoters of snRNA genes, and helps to recruit TBP (PMID: 8633057)	IPR021281	6618	small nuclear RNA activating complex polypeptide 2 [Source:HGNC Symbol;Acc:HGNC:11135]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000104976#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7715707, PMID:8524284	$#ENSP00000221573#ENSG00000104976#ENST00000221573#Other#SnAPC_2_like$#ENSP00000471962#ENSG00000104976#ENST00000597584#Other#SnAPC_2_like$#ENSP00000469475#ENSG00000104976#ENST00000595637#Other#SnAPC_2_like	FALSE
2550	ENSG00000174446	SNAPC5	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds specifically to the PSE (PMID: 9732265)	IPR029138	10302	small nuclear RNA activating complex polypeptide 5 [Source:HGNC Symbol;Acc:HGNC:15484]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000174446#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000308439#ENSG00000174446#ENST00000307979#Other#GDE_N, SNAPc19$#ENSP00000319597#ENSG00000174446#ENST00000316634#Other#DUF4724, SNAPc19$#ENSP00000378954#ENSG00000174446#ENST00000395589#Other#DUF4724, SNAPc19$#ENSP00000457892#ENSG00000174446#ENST00000563480#Other#DUF4724, SNAPc19	FALSE
2551	ENSG00000124562	SNRPC	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Component of the spliceosomal U1 snRNP	IPR000690;IPR003604;IPR013085;IPR017340	6631	small nuclear ribonucleoprotein polypeptide C [Source:HGNC Symbol;Acc:HGNC:11157]	None	not tested	not tested	None	None	No	No	TF Evidence Conflict - There is evidence for and against this genes role as a TF__TF PPI_PMIDS:10827180;	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000124562##Other#	FALSE
2552	ENSG00000273173	SNURF	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely a TF co-factor	IPR009847	8926	SNRPN upstream reading frame [Source:HGNC Symbol;Acc:HGNC:11171]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9710597	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$##ENSG00000273173##Other#	FALSE
2553	ENSG00000100603	SNW1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR004015	22938	SNW domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16696]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:9632709	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$##ENSG00000100603##Other#	FALSE
2554	ENSG00000214338	SOGA3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contain any likely DBDs.	IPR027881	387104	SOGA family member 3 [Source:HGNC Symbol;Acc:HGNC:21494]	None	not tested	not tested	None	None	No	Yes	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Jussi Taipale	No	None	$#ENSP00000431662#ENSG00000214338#ENST00000467753#bZIP#$#ENSP00000435559#ENSG00000214338#ENST00000465909#bZIP#SOGA, TSC22$#ENSP00000434570#ENSG00000214338#ENST00000525778#bZIP#SOGA, TSC22	FALSE
2555	ENSG00000159140	SON	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	The protein has been reported to bind a GAKANSRCC consensus based on SELEX experiments. Recognizes a matching GAGACCACC sequence in a hepatitis B virus regulatory element (PMID: 11306577)	IPR000467;IPR014720;IPR017986	102465248	SON DNA binding protein [Source:HGNC Symbol;Acc:HGNC:11183]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:1424986	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$##ENSG00000159140##Other#	FALSE
2556	ENSG00000154556	SORBS2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001452;IPR003127;IPR007087;	8470	sorbin and SH3 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24098]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$#ENSP00000284776#ENSG00000154556#ENST00000284776#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000321983#ENSG00000154556#ENST00000319454#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000322182#ENSG00000154556#ENST00000319471#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000377162#ENSG00000154556#ENST00000393528#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000396008#ENSG00000154556#ENST00000437304#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000397262#ENSG00000154556#ENST00000449407#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000347852#ENSG00000154556#ENST00000355634#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000397482#ENSG00000154556#ENST00000418609#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000415637#ENSG00000154556#ENST00000425679#Other#$#ENSP00000410483#ENSG00000154556#ENST00000444771#Other#Sorb$#ENSP00000409158#ENSG00000154556#ENST00000448662#Other#SH3_1, SH3_2, SH3_9, Sorb$#ENSP00000408504#ENSG00000154556#ENST00000419063#Other#$#ENSP00000405646#ENSG00000154556#ENST00000421639#Other#$#ENSP00000407006#ENSG00000154556#ENST00000432655#Other#$#ENSP00000404430#ENSG00000154556#ENST00000451701#Other#	FALSE
2557	ENSG00000065526	SPEN	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	Has a putative AT-hook	Data inconclusive. Contains RRM domains, suggesting RNA binding activity. Gel-shift experiments demonstrate that SPEN (aka MINT) binds ss and dsDNA G- and T-rich elements (PMID: 10451362), but in another system SPEN does not bind DNA directly and is recruited (PMID: 15778499). RNA-binding activities have also been documented (PMID: 24748666).	IPR000504;IPR010912;IPR012921;IPR016194	23013	spen family transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:17575]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Single stranded RNA/DNA binding_DNA Binding_PMIDS:10451362;15778499	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$##ENSG00000065526##Other#	FALSE
2558	ENSG00000176170	SPHK1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001206;IPR016064	8877	sphingosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11240]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000176170#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:20577214	$#ENSP00000313681#ENSG00000176170#ENST00000323374#Other#DAGK_cat$#ENSP00000376285#ENSG00000176170#ENST00000392496#Other#DAGK_cat$#ENSP00000468547#ENSG00000176170#ENST00000590959#Other#DAGK_cat$#ENSP00000465726#ENSG00000176170#ENST00000592299#Other#DAGK_cat$#ENSP00000440970#ENSG00000176170#ENST00000545180#Other#DAGK_cat$#ENSP00000466422#ENSG00000176170#ENST00000588682#Other#DAGK_cat$#ENSP00000465002#ENSG00000176170#ENST00000590379#Other#DAGK_cat	FALSE
2559	ENSG00000164299	SPZ1	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Binds to E-boxes (EMSA) (PMID: 15226296)	IPR029780	84654	spermatogenic leucine zipper 1 [Source:HGNC Symbol;Acc:HGNC:30721]	None	Full	Yes	None	None	No	Yes	TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11165476	Yes	2a1, Lower confidence direct evidence	Pratyush Das	Laura Campitelli	No	$#ENSG00000164299#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000426530#ENSG00000164299#ENST00000511881#Other#PCRF$#ENSP00000369611#ENSG00000164299#ENST00000296739#Other#DUF3150	FALSE
2560	ENSG00000138385	SSB	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PMID: 3192525; PMID: 2470590]	IPR000504;IPR002344;IPR006630;IPR014886	6741	Sjogren syndrome antigen B [Source:HGNC Symbol;Acc:HGNC:11316]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000260956#ENSG00000138385#ENST00000260956#Other#La$#ENSP00000386636#ENSG00000138385#ENST00000409333#Other#La$#ENSP00000396890#ENSG00000138385#ENST00000417292#Other#$#ENSP00000397029#ENSG00000138385#ENST00000422006#Other#La	FALSE
2561	ENSG00000145687	SSBP2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in DNA damage response. Has domain IPR008116 Sequence-specific single-strand DNA-binding protein	None	23635	Single-stranded DNA-binding protein 2	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000145687#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$##ENSG00000145687##Other#	FALSE
2562	ENSG00000157216	SSBP3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Single stranded DNA binding protein. There is no evidence for sequence specificity, although it can operate as a transcriptional co-regulator (PMID: 26495868)	None	23648	Single-stranded DNA-binding protein 3	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000157216#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$##ENSG00000157216##Other#	FALSE
2563	ENSG00000130511	SSBP4	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	(PMID:9531483) shows that the SSDP_DNA-bd domain has sequence-specific single-stranded DNA-binding activity.	None	170463	Single-stranded DNA-binding protein 4	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Tim Hughes	No	$#ENSG00000130511#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IBA - GO_REF:0000033	$##ENSG00000130511##Other#	FALSE
2564	ENSG00000084112	SSH1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000340;IPR000387;IPR014876;IPR016130;IPR020422;IPR029021	54434	slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000315713#ENSG00000084112#ENST00000326495#Other#DEK_C, DSPc$#ENSP00000448824#ENSG00000084112#ENST00000551165#Other#DEK_C, DSPc$#ENSP00000326107#ENSG00000084112#ENST00000326470#Other#DEK_C, DSPc$#ENSP00000446652#ENSG00000084112#ENST00000546697#Other#	FALSE
2565	ENSG00000141298	SSH2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000340;IPR000387;IPR014876;IPR016130;IPR020422;IPR029021	85464	slingshot protein phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:30580]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Laura Campitelli	No	None	$#ENSP00000269033#ENSG00000141298#ENST00000269033#Other#DEK_C, DSPc$#ENSP00000444743#ENSG00000141298#ENST00000540801#Other#DEK_C, DSPc$#ENSP00000465703#ENSG00000141298#ENST00000577991#Other#$#ENSP00000468037#ENSG00000141298#ENST00000579954#Other#$#ENSP00000462583#ENSG00000141298#ENST00000582084#Other#	FALSE
2566	ENSG00000172830	SSH3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000340;IPR000387;IPR014876;IPR016130;IPR020422;IPR029021	54961	slingshot protein phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:30581]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	None	$#ENSP00000312081#ENSG00000172830#ENST00000308127#Other#DEK_C, DSPc, Y_phosphatase$#ENSP00000310055#ENSG00000172830#ENST00000308298#Other#$#ENSP00000365948#ENSG00000172830#ENST00000376757#Other#DEK_C, DSPc, Y_phosphatase$#ENSP00000433902#ENSG00000172830#ENST00000527821#Other#DEK_C, DSPc, Y_phosphatase$#ENSP00000480198#ENSG00000172830#ENST00000532181#Other#DEK_C, DSPc	FALSE
2567	ENSG00000126752	SSX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001909;IPR003655;IPR019041	6756	SSX family member 1 [Source:HGNC Symbol;Acc:HGNC:11335]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000126752##Other#	FALSE
2568	ENSG00000118007	STAG1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Part of the cohesin complex	None	10274	Cohesin subunit SA-1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000118007#GO:0001228#RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor#IEA - GO_REF:0000019	$##ENSG00000118007##Other#	FALSE
2569	ENSG00000115661	STK16	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	8576	Serine/threonine-protein kinase 16	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Matt Weirauch	No	$#ENSG00000115661#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IEA - GO_REF:0000019	$##ENSG00000115661##Other#	FALSE
2570	ENSG00000104375	STK3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Kinase - included only because GO says it regulates TFs	IPR000719;IPR002290;IPR011009;IPR011524;IPR017441;IPR024205	6788	serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:11406]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	$#ENSG00000104375#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IGI - PMID:22292086	$#ENSP00000390500#ENSG00000104375#ENST00000419617#Other#Mst1_SARAH, Pkinase, Pkinase_Tyr$#ENSP00000428014#ENSG00000104375#ENST00000518165#Other#Pkinase, Pkinase_Tyr$#ENSP00000429744#ENSG00000104375#ENST00000523601#Other#Mst1_SARAH, Pkinase, Pkinase_Tyr$#ENSP00000428295#ENSG00000104375#ENST00000519420#Other#	FALSE
2571	ENSG00000163482	STK36	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR008271;IPR011009;IPR016024;IPR017441	27148	serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	$#ENSG00000163482#GO:0007228#positive regulation of hh target transcription factor activity#ISS - GO_REF:0000024$#ENSG00000163482#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10806483	$#ENSP00000295709#ENSG00000163482#ENST00000295709#Other#APH, Cnd1, HEAT, HEAT_2, HEAT_EZ, Kinase-like, Pki$#ENSP00000375954#ENSG00000163482#ENST00000392105#Other#APH, Cnd1, HEAT, HEAT_2, HEAT_EZ, Kinase-like, Pki$#ENSP00000400055#ENSG00000163482#ENST00000455724#Other#Pkinase, Pkinase_Tyr	FALSE
2572	ENSG00000115808	STRN	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001680;IPR013258;IPR017986;IPR019775;IPR020472	6801	striatin [Source:HGNC Symbol;Acc:HGNC:11424]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:11570823	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$##ENSG00000115808##Other#	FALSE
2573	ENSG00000196792	STRN3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	GO annotation has no evidence for DNA-binding activity (PMID: 11570823), and STRN3 lacks a canonical DBD	IPR001680;IPR013258;IPR017986;IPR019775;IPR020472	29966	striatin 3 [Source:HGNC Symbol;Acc:HGNC:15720]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000347909#ENSG00000196792#ENST00000355683#Other#ANAPC4_WD40, Nup160, Striatin, WD40$#ENSP00000451233#ENSG00000196792#ENST00000555152#Other#Striatin	FALSE
2574	ENSG00000113387	SUB1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	The structure (PDB: 2C62) demonstrates binding to single stranded DNA	IPR003173;IPR009044	10923	SUB1 homolog, transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:19985]	2C62	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9482861	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000113387#GO:0001205#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv#IEA - GO_REF:0000019	$##ENSG00000113387##Other#	FALSE
2575	ENSG00000107882	SUFU	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR016591;IPR020941;IPR024314	51684	SUFU negative regulator of hedgehog signaling [Source:HGNC Symbol;Acc:HGNC:16466]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000107882#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#TAS - PMID:11001584	$#ENSP00000358915#ENSG00000107882#ENST00000369899#Other#SUFU, SUFU_C$#ENSP00000358918#ENSG00000107882#ENST00000369902#Other#SUFU, SUFU_C$#ENSP00000411597#ENSG00000107882#ENST00000423559#Other#SUFU, SUFU_C	FALSE
2576	ENSG00000116030	SUMO1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000626;IPR022617;IPR029071	7341	small ubiquitin-like modifier 1 [Source:HGNC Symbol;Acc:HGNC:12502]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000116030#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12072434	$#ENSP00000376077#ENSG00000116030#ENST00000392246#Other#Rad60-SLD, ubiquitin$#ENSP00000376075#ENSG00000116030#ENST00000392244#Other#Rad60-SLD, ubiquitin$#ENSP00000386267#ENSG00000116030#ENST00000409205#Other#Rad60-SLD, ubiquitin$#ENSP00000386296#ENSG00000116030#ENST00000409712#Other#Rad60-SLD, ubiquitin$#ENSP00000376076#ENSG00000116030#ENST00000392245#Other#Rad60-SLD, ubiquitin$#ENSP00000386753#ENSG00000116030#ENST00000409181#Other#Rad60-SLD, ubiquitin$#ENSP00000386472#ENSG00000116030#ENST00000409498#Other#Rad60-SLD, ubiquitin	FALSE
2577	ENSG00000092201	SUPT16H	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Component of the FACT histone remodeling complex, which functions in transcriptional elongation (PMID: 12934006). (PDB: 4Z2M) shows that the protein contacts H3 and H4 proteins, but it could also contact DNA	IPR000994;IPR013719;IPR013953;IPR029148	11198	SPT16 homolog, facilitates chromatin remodeling subunit [Source:HGNC Symbol;Acc:HGNC:11465]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:12934006;10421373;12934006	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$##ENSG00000092201##Other#	FALSE
2578	ENSG00000213246	SUPT4H1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Involved in transcription elongation (PMID: 9450929)	IPR009287;IPR022800;IPR029040	6827	SPT4 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11467]	None	not tested	not tested	None	None	No	No	TF Evidence Conflict - There is evidence for and against this genes role as a TF_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:8649394;8660457;8786137;11101522;12653964	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000213246#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8649394	$#ENSP00000225504#ENSG00000213246#ENST00000225504#Other#Spt4$#ENSP00000462100#ENSG00000213246#ENST00000577396#Other#Spt4$#ENSP00000464618#ENSG00000213246#ENST00000581540#Other#Spt4$#ENSP00000462670#ENSG00000213246#ENST00000580947#Other#Spt4	FALSE
2579	ENSG00000196235	SUPT5H	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Protein that regulates transcriptional elongation (PMID: 9450929)	IPR005100;IPR005824;IPR006645;IPR008991;IPR017071;IPR022581;IPR024945	6829	SPT5 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11469]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:9450929	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$##ENSG00000196235##Other#	FALSE
2580	ENSG00000109111	SUPT6H	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	SPT6 is an elongation factor, not a TF.  GO needs to be corrected - (PMID: 8786132) does not demonstrate sequence specificity or DNA binding.	IPR000980;IPR003029;IPR006641;IPR010994;IPR012337;IPR012340;IPR017072;IPR022967;IPR027999;IPR028083;IPR028088;	6830	SPT6 homolog, histone chaperone [Source:HGNC Symbol;Acc:HGNC:11470];Transcription elongation factor	None	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF___PMIDS:0	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000109111#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8786132	$#ENSP00000319104#ENSG00000109111#ENST00000314616#Other#DLD, HHH_3, HHH_7, HTH_44, S1, SH2, SH2_2, SPT6_ac$#ENSP00000338143#ENSG00000109111#ENST00000347486#Other#DLD, HHH_3, HHH_7, HTH_44, S1, SH2, SH2_2, SPT6_ac$#ENSP00000464545#ENSG00000109111#ENST00000577713#Other#MRC1	FALSE
2581	ENSG00000101945	SUV39H1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a histone methyltransferase that trimethylates lysine 9 of histone H3	IPR000953;IPR001214;IPR003606;IPR003616;IPR007728;IPR011381;IPR016197;IPR023779;IPR023780	6839	suppressor of variegation 3-9 homolog 1 [Source:HGNC Symbol;Acc:HGNC:11479]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15107829	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$##ENSG00000101945##Other#	FALSE
2582	ENSG00000152455	SUV39H2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Histone (H3K9) methyltransferase. Also directs DNA methylation (UniProt: Q9H5I1) (PMID: 14765126)	IPR000953;IPR001214;IPR003606;IPR003616;IPR007728;IPR011381;IPR016197;IPR023779;IPR023780	79723	suppressor of variegation 3-9 homolog 2 [Source:HGNC Symbol;Acc:HGNC:17287]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11094092;15107829	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Laura Campitelli	No	None	$##ENSG00000152455##Other#	FALSE
2583	ENSG00000178691	SUZ12	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Protein is a component of the PRC2 repressor complex, which silences DNA through histone methylation. The protein has two znf C2H2-like domains that appear to be used in association with chromatin (PMID: 24100017)	IPR019135;	23512	SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:17101]	None	Full	not tested	None	None	x	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15225548;16751344	No	4a, two or more datasets predict it as a TF	Pratyush Das	Arttu Jolma	No	None	$#ENSP00000316578#ENSG00000178691#ENST00000322652#Other#DUF2070, VEFS-Box$#ENSP00000463936#ENSG00000178691#ENST00000580398#Other#DUF2070, VEFS-Box	FALSE
2584	ENSG00000165025	SYK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Known co-factor	IPR000719;IPR000980;IPR001245;IPR008266;IPR011009;IPR012234;IPR017441;IPR020635	6850	spleen tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	$#ENSG00000165025#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23071339	$#ENSP00000364898#ENSG00000165025#ENST00000375746#Other#Kdo, Pkinase, Pkinase_Tyr, SH2$#ENSP00000364899#ENSG00000165025#ENST00000375747#Other#Kdo, Pkinase, Pkinase_Tyr, SH2$#ENSP00000364904#ENSG00000165025#ENST00000375751#Other#Kdo, Pkinase, Pkinase_Tyr, SH2$#ENSP00000364907#ENSG00000165025#ENST00000375754#Other#Kdo, Pkinase, Pkinase_Tyr, SH2	FALSE
2585	ENSG00000100324	TAB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001932	10454	TGF-beta activated kinase 1/MAP3K7 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:18157]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	$#ENSG00000100324#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000216160#ENSG00000100324#ENST00000216160#Other#PP2C$#ENSP00000333049#ENSG00000100324#ENST00000331454#Other#PP2C	FALSE
2586	ENSG00000055208	TAB2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Works as a protein-protein interaction adapter to recruit TAK1-kinase (PMID: 10882101). Could also work as an RBP, based on presence of a zf-RanBP domain	IPR001876;IPR003892	23118	TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17075]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	$#ENSG00000055208#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000476139#ENSG00000055208#ENST00000606202#Other#$#ENSP00000490379#ENSG00000055208#ENST00000636456#Other#zf-RanBP$#ENSP00000490618#ENSG00000055208#ENST00000637181#Other#CUE, zf-RanBP	FALSE
2587	ENSG00000157625	TAB3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR001876;IPR003892	257397	TGF-beta activated kinase 1/MAP3K7 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:30681]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000157625#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000368212#ENSG00000157625#ENST00000378930#Other#CUE, zf-RanBP$#ENSP00000368214#ENSG00000157625#ENST00000378932#Other#CUE, zf-RanBP$#ENSP00000368215#ENSG00000157625#ENST00000378933#Other#CUE, zf-RanBP$#ENSP00000288422#ENSG00000157625#ENST00000288422#Other#CUE	FALSE
2588	ENSG00000171148	TADA3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Paper cited by GO annotation has no evidence of specific DNA-binding activity (PMID: 9674425), and is based on experiments using an entire complex	IPR019340	10474	transcriptional adaptor 3 [Source:HGNC Symbol;Acc:HGNC:19422]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12034840	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000171148#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9674425	$#ENSP00000307684#ENSG00000171148#ENST00000301964#Other#Ada3$#ENSP00000343649#ENSG00000171148#ENST00000343450#Other#Ada3$#ENSP00000395073#ENSG00000171148#ENST00000439043#Other#$#ENSP00000393471#ENSG00000171148#ENST00000440161#Other#Ada3	FALSE
2589	ENSG00000147133	TAF1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Contacts DNA in the structure (PDB: 5FUR).  Transfac motifs are suspect, and are probably in vivo signals derived from promoter binding TFs (e.g. YY1 and ETS)	IPR001487;IPR009067;IPR011177;IPR018359;IPR022591	6872	TATA-box binding protein associated factor 1 [Source:HGNC Symbol;Acc:HGNC:11535];Transcription initi	5FUR	not tested	not tested	None	None	No	Yes	No	Yes	2a1, Lower confidence direct evidence	Arttu Jolma	Pratyush Das	Yes	$#ENSG00000147133#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033$#ENSG00000147133#GO:2000825#positive regulation of androgen receptor activity#IDA - PMID:20181722	$#ENSP00000362895#ENSG00000147133#ENST00000373790#Other#Bromodomain, DUF3591, TBP-binding, zf-CCHC_6$#ENSP00000421611#ENSG00000147133#ENST00000463163#Other#Bromodomain$#ENSP00000424526#ENSG00000147133#ENST00000483985#Other#zf-CCHC_6	FALSE
2590	ENSG00000166337	TAF10	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	General transcription factor	IPR003923	6881	TATA-box binding protein associated factor 10 [Source:HGNC Symbol;Acc:HGNC:11543]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI; Transactivation_PMIDS:7923369	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	No	$#ENSG00000166337#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525	$#ENSP00000299424#ENSG00000166337#ENST00000299424#Other#Bromo_TP, TFIID_30kDa$#ENSP00000480402#ENSG00000166337#ENST00000527248#Other#Bromo_TP, TFIID_30kDa	FALSE
2591	ENSG00000064995	TAF11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not interact with DNA (PMID: 15657423)	IPR006809;IPR009072	6882	TATA-box binding protein associated factor 11 [Source:HGNC Symbol;Acc:HGNC:11544]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8670810;9108034	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Yimeng Yin	No	None	$##ENSG00000064995##Other#	FALSE
2592	ENSG00000120656	TAF12	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	(PMID: 15601843) shows it has DNA binding activity in a complex with TAF4b.	IPR003228;IPR009072	6883	TATA-box binding protein associated factor 12 [Source:HGNC Symbol;Acc:HGNC:11545]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7729427;15735663	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Laura Campitelli	No	$#ENSG00000120656#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525$#ENSG00000120656#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:15735663	$#ENSP00000263974#ENSG00000120656#ENST00000263974#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-31kDa, TFI$#ENSP00000362930#ENSG00000120656#ENST00000373824#Other#CBFD_NFYB_HMF, CENP-T_C, Histone, TFIID-31kDa, TFI	FALSE
2593	ENSG00000197780	TAF13	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Forms heterodimer TAF11:TAF13, which has a histone-fold like structure and could thus bind DNA in a non- or low specific manner (PMID: 9695952)	IPR003195;IPR009072	6884	TATA-box binding protein associated factor 13 [Source:HGNC Symbol;Acc:HGNC:11546];Transcription init	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000197780#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:9695952	$#ENSP00000355051#ENSG00000197780#ENST00000338366#Other#TFIID-18kDa	FALSE
2594	ENSG00000143498	TAF1A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	General TF. Directly binds to DNA, likely in a non sequence-specific manner (PMID: 15970593), although it is possible it might have some specificity.	IPR016629	9015	TATA-box binding protein associated factor, RNA polymerase I subunit A [Source:HGNC Symbol;Acc:HGNC:	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor__PMIDS:0;8013460	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	None	$##ENSG00000143498##Other#	FALSE
2595	ENSG00000115750	TAF1B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Pol I TAF that contacts the rDNA promoter in conjunction with TBP and UBF (PMID: 7491500).  No clear evidence that it directly confers sequence specificity.	IPR021752	9014	TATA-box binding protein associated factor, RNA polymerase I subunit B [Source:HGNC Symbol;Acc:HGNC:	None	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF___PMIDS:0	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Arttu Jolma	No	$#ENSG00000115750#GO:0001187#RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcri#IDA - PMID:21921198, PMID:21921199$#ENSG00000115750#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7801123	$#ENSP00000263663#ENSG00000115750#ENST00000263663#Other#zf-RRN7$#ENSP00000475608#ENSG00000115750#ENST00000492648#Other#$#ENSP00000486572#ENSG00000115750#ENST00000625239#Other#NOB1_Zn_bind, zf-RRN7	FALSE
2596	ENSG00000103168	TAF1C	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC.	IPR017986	9013	TATA-box binding protein associated factor, RNA polymerase I subunit C [Source:HGNC Symbol;Acc:HGNC:	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7801123;9050847	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$##ENSG00000103168##Other#	FALSE
2597	ENSG00000122728	TAF1L	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Involved in preinitiation complex assembly (general transcriptional machinery. Is a paralog of TAF1, which binds DNA based on the structure (PDB: 5FUR)	IPR001487;IPR009067;IPR011177;IPR018359;IPR022591	138474	TATA-box binding protein associated factor 1 like [Source:HGNC Symbol;Acc:HGNC:18056];Transcription	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7590250	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Laura Campitelli	No	$#ENSG00000122728#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033	$#ENSP00000418379#ENSG00000122728#ENST00000242310#Other#Bromodomain, DUF3591, TBP-binding, zf-CCHC_6	FALSE
2598	ENSG00000064313	TAF2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Directly contact with DNA in TFIID complex (PMID: 27096372), and mediate major interactions with the downstream promoter together with TAF1. Contacts DNA in the structure (PDB: 5FUR)	IPR014782;IPR016024	6873	TATA-box binding protein associated factor 2 [Source:HGNC Symbol;Acc:HGNC:11536];Transcription initi	5FUR	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9774672	Yes	4a, two or more datasets predict it as a TF	Yimeng Yin	Laura Campitelli	No	$#ENSG00000064313#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033	$#ENSP00000367406#ENSG00000064313#ENST00000378164#Other#HEAT_2, Peptidase_M1$#ENSP00000430832#ENSG00000064313#ENST00000523904#Other#$#ENSP00000436750#ENSG00000064313#ENST00000529653#Other#	FALSE
2599	ENSG00000165632	TAF3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contacts chromatin through modified histones and TFs such as TP53 (PMID: 18549481)	IPR001965;IPR006565;IPR011011;IPR019786;IPR019787	83860	TATA-box binding protein associated factor 3 [Source:HGNC Symbol;Acc:HGNC:17303]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11438666	Yes	4a, two or more datasets predict it as a TF	Arttu Jolma	Pratyush Das	No	$#ENSG00000165632#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:18549481	$#ENSP00000340271#ENSG00000165632#ENST00000344293#Other#Bromo_TP, Gti1_Pac2, PHD	FALSE
2600	ENSG00000130699	TAF4	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	The TAF4 domain interacts with TAF12 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function for of a subset of genes (PMID: 19635797; PMID: 12237304)	IPR003894;IPR007900;IPR009072	100302168	TATA-box binding protein associated factor 4 [Source:HGNC Symbol;Acc:HGNC:11537]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000130699#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033$#ENSG00000130699#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525	$#ENSP00000252996#ENSG00000130699#ENST00000252996#Other#TAF4, TAFH$#ENSP00000476270#ENSG00000130699#ENST00000474089#Other#TAF4$#ENSP00000476294#ENSG00000130699#ENST00000488539#Other#TAF4, TAFH	FALSE
2601	ENSG00000141384	TAF4B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Histone-like protein that binds DNA as an obligate heterodimeric complex with TAF12 (PMID: 19635797). Target sequence needs to be over 70 bases long and doesnt appear to have sequence specificity	IPR003894;IPR007900;IPR009072	6875	TATA-box binding protein associated factor 4b [Source:HGNC Symbol;Acc:HGNC:11538]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11557891;16473943	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000141384#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033	$##ENSG00000141384##Other#	FALSE
2602	ENSG00000148835	TAF5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001680;IPR006594;IPR007582;IPR017986;IPR019775;IPR020472	6877	TATA-box binding protein associated factor 5 [Source:HGNC Symbol;Acc:HGNC:11539];Transcription initi	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000148835#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525 | IMP - PMID:9045704	$#ENSP00000358854#ENSG00000148835#ENST00000369839#Other#ANAPC4_WD40, Ge1_WD40, Nup160, RAB3GAP2_N, TFIID_N	FALSE
2603	ENSG00000135801	TAF5L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Paralog of TAF5 that is unlikely to contact DNA (PMID: 17227857)	IPR001680;IPR007582;IPR017986;IPR019775;IPR020472	27097	TATA-box binding protein associated factor 5 like [Source:HGNC Symbol;Acc:HGNC:17304];TAF5-like RNA	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	$#ENSG00000135801#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9674425	$#ENSP00000355635#ENSG00000135801#ENST00000366675#Other#TFIID_NTD2$#ENSP00000355636#ENSG00000135801#ENST00000366676#Other#ANAPC4_WD40, Ge1_WD40, Nup160, TFIID_NTD2, WD40, W$#ENSP00000355634#ENSG00000135801#ENST00000366674#Other#$#ENSP00000258281#ENSG00000135801#ENST00000258281#Other#ANAPC4_WD40, Ge1_WD40, Nup160, TFIID_NTD2, WD40, W	FALSE
2604	ENSG00000106290	TAF6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5FUR)	IPR004823;IPR009072;IPR011442;IPR016024	6878	TATA-box binding protein associated factor 6 [Source:HGNC Symbol;Acc:HGNC:11540];Transcription initi	5FUR	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7667268	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000106290#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525$#ENSG00000106290#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000344537#ENSG00000106290#ENST00000344095#Other#Bromo_TP, TAF, TAF6_C, TFIID-31kDa$#ENSP00000416396#ENSG00000106290#ENST00000452041#Other#Bromo_TP, TAF, TAF6_C, TFIID-31kDa$#ENSP00000389575#ENSG00000106290#ENST00000453269#Other#Bromo_TP, TAF, TAF6_C, TFIID-31kDa$#ENSP00000419760#ENSG00000106290#ENST00000472509#Other#TAF, TAF6_C, TFIID-31kDa$#ENSP00000399982#ENSG00000106290#ENST00000437822#Other#TAF, TAF6_C, TFIID-31kDa$#ENSP00000410012#ENSG00000106290#ENST00000440225#Other#Bromo_TP, Histone, TAF, TFIID-18kDa, TFIID-31kDa$#ENSP00000419555#ENSG00000106290#ENST00000493322#Other#Bromo_TP, TAF, TFIID-18kDa, TFIID-31kDa$#ENSP00000428071#ENSG00000106290#ENST00000520135#Other#TAF	FALSE
2605	ENSG00000162227	TAF6L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Part of the PCAF Histone Acetylase Complex (PMID: 9674425). Structurally similar to TAF6, which does not contact DNA directly	IPR004823;IPR009072;IPR011442	10629	TATA-box binding protein associated factor 6 like [Source:HGNC Symbol;Acc:HGNC:17305]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:9674425	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000162227#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$##ENSG00000162227##Other#	FALSE
2606	ENSG00000178913	TAF7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5FUR)	IPR006751	6879	TATA-box binding protein associated factor 7 [Source:HGNC Symbol;Acc:HGNC:11541];Transcription initi	5FUR	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:16407123	Yes	4a, two or more datasets predict it as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000178913#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:9603525	$#ENSP00000485510#ENSG00000178913#ENST00000624761#Other#TAFII55_N$#ENSP00000312709#ENSG00000178913#ENST00000313368#Other#TAFII55_N	FALSE
2607	ENSG00000102387	TAF7L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR006751	54457	TATA-box binding protein associated factor 7 like [Source:HGNC Symbol;Acc:HGNC:11548]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Basal Transcription Factor_TF PPI_PMIDS:12665565	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Pratyush Das	No	None	$##ENSG00000102387##Other#	FALSE
2608	ENSG00000137413	TAF8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contact DNA in the structure (PDB: 5FUR)	IPR006565;IPR009072;IPR019473	129685	TATA-box binding protein associated factor 8 [Source:HGNC Symbol;Acc:HGNC:17300]	5FUR	not tested	not tested	None	None	No	No	TF Gene Candidate_Basal Transcription Factor_Transactivation_PMIDS:14580349;15870280	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$##ENSG00000137413##Other#	FALSE
2609	ENSG00000273841	TAF9	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Related to histone H3.  (PMID: 15601843) shows DNA binding activity in complex with TAF4b, but does not demonstrate intrinsic sequence specificity. May contact promoter DNA (PMID: 23292512)	IPR003162;IPR009072	6880	TATA-box binding protein associated factor 9 [Source:HGNC Symbol;Acc:HGNC:11542]	None	not tested	not tested	None	None	No	No	TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7597030;7761466	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$##ENSG00000273841##Other#	FALSE
2610	ENSG00000187325	TAF9B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003162;IPR009072	51616	TATA-box binding protein associated factor 9b [Source:HGNC Symbol;Acc:HGNC:17306]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000187325#GO:0001075#RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved#IBA - GO_REF:0000033	$#ENSP00000339917#ENSG00000187325#ENST00000341864#Other#Bromo_TP, CENP-S, TFIID-31kDa	FALSE
2611	ENSG00000120948	TARDBP	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Is an RNA-binding protein that can also bind single stranded DNA, as in the structure (PDB: 3D2W)	IPR000504	23435	TAR DNA binding protein [Source:HGNC Symbol;Acc:HGNC:11571]	3D2W	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF___PMIDS:0	Yes	3a, decent circumstantial evidence for its role as	Arttu Jolma	Yimeng Yin	No	$#ENSG00000120948#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7745706	$#ENSP00000240185#ENSG00000120948#ENST00000240185#Other#$#ENSP00000465240#ENSG00000120948#ENST00000473118#Other#$#ENSP00000480690#ENSG00000120948#ENST00000621715#Other#	FALSE
2612	ENSG00000106052	TAX1BP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR012852;	8887	Tax1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11575]	None	not tested	not tested	None	None	c	No	No	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Jussi Taipale	No	$#ENSG00000106052#GO:0032088#negative regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000265393#ENSG00000106052#ENST00000265393#Other#CALCOCO1$#ENSP00000379612#ENSG00000106052#ENST00000396319#Other#CALCOCO1$#ENSP00000391907#ENSG00000106052#ENST00000433216#Other#CALCOCO1, zf-C2H2_4$#ENSP00000444811#ENSG00000106052#ENST00000543117#Other#CALCOCO1$#ENSP00000395290#ENSG00000106052#ENST00000422800#Other#CALCOCO1	FALSE
2613	ENSG00000092377	TBL1Y	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD. Included as a candidate only because TFcat lists it as a putative coactivator.	IPR001680;IPR006594;IPR017986;IPR019775;IPR020472	90665	transducin (beta)-like 1, Y-linked [Source:HGNC Symbol;Acc:HGNC:18502]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:12628926	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	None	$##ENSG00000092377##Other#	FALSE
2614	ENSG00000171703	TCEA2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely binds RNA based on similarity to TCEA1	IPR001222;IPR003617;IPR003618;IPR006289;IPR016492;IPR017890;IPR017923	6919	transcription elongation factor A2 [Source:HGNC Symbol;Acc:HGNC:11614]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:9305922;15507123	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$##ENSG00000171703##Other#	FALSE
2615	ENSG00000172465	TCEAL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR021156	9338	Transcription elongation factor A protein-like 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	$#ENSG00000172465#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:7971997	$#ENSP00000361707#ENSG00000172465#ENST00000372624#Other#BEX$#ENSP00000361708#ENSG00000172465#ENST00000372625#Other#BEX$#ENSP00000361709#ENSG00000172465#ENST00000372626#Other#BEX	FALSE
2616	ENSG00000182916	TCEAL7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Modulates transcription, but there is no evidence for DNA binding (PMID: 19966855)	IPR021156	56849	transcription elongation factor A like 7 [Source:HGNC Symbol;Acc:HGNC:28336]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	$#ENSG00000182916#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:19966855	$#ENSP00000329794#ENSG00000182916#ENST00000332431#Other#BEX$#ENSP00000361751#ENSG00000182916#ENST00000372666#Other#BEX	FALSE
2617	ENSG00000180964	TCEAL8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Lacks a canonical DBD	IPR021156;	90843	transcription elongation factor A like 8 [Source:HGNC Symbol;Acc:HGNC:28683]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$#ENSP00000353093#ENSG00000180964#ENST00000360000#Other#BEX$#ENSP00000361770#ENSG00000180964#ENST00000372685#Other#BEX$#ENSP00000390880#ENSG00000180964#ENST00000451678#Other#BEX	FALSE
2618	ENSG00000137310	TCF19	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Previous evidence (PMID: 1868030) for TF activity is based on sequence analysis (high proline content), and presence of an FHA domain. However, neither prove ability to bind DNA in a sequence-specific manner	IPR000253;IPR001965;IPR008984;IPR011011;IPR019786;IPR019787	6941	transcription factor 19 [Source:HGNC Symbol;Acc:HGNC:11629]	None	not tested	not tested	None	None	other	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000137310#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1868030	$#ENSP00000365431#ENSG00000137310#ENST00000376255#Other#FHA, PHD$#ENSP00000365433#ENSG00000137310#ENST00000376257#Other#FHA, PHD$#ENSP00000439397#ENSG00000137310#ENST00000542218#Other#	FALSE
2619	ENSG00000100207	TCF20	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	(PMID: 7760812) identified this protein in a library screen and demonstrated DNA binding of an IVT product to an enhancer of interest. They also identified a putative bZIP domain that is not detected by Pfam or SMART.  (PMID:10995766) subsequently mapped the strongest DNA binding site.	IPR001965;	6942	transcription factor 20 (AR1) [Source:HGNC Symbol;Acc:HGNC:11631]	None	not tested	not tested	None	None	other	No	TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7760812;10849425;10995766	Yes	4a, two or more datasets predict it as a TF	Laura Campitelli	Tim Hughes	No	$#ENSG00000100207#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000335561#ENSG00000100207#ENST00000335626#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000352463#ENSG00000100207#ENST00000359486#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000385531#ENSG00000100207#ENST00000404876#Other#zf-HC5HC2H, zf-HC5HC2H_2$#ENSP00000458948#ENSG00000100207#ENST00000515426#Other#	FALSE
2620	ENSG00000141002	TCF25	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Only evidence is based on (PMID:16574069), which claims that hnulp1 (TCF25) contains a possible bHLH domain and that it represses transcription in a Gal4-forced recruitment assay.	IPR006994;	22980	transcription factor 25 [Source:HGNC Symbol;Acc:HGNC:29181]	None	not tested	not tested	None	None	other	No	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Laura Campitelli	Yes	$#ENSG00000141002#GO:0003700#sequence-specific DNA binding transcription factor activity#IDA - PMID:16574069	$#ENSP00000263346#ENSG00000141002#ENST00000263346#Other#Tcf25$#ENSP00000455611#ENSG00000141002#ENST00000562256#Other#Tcf25$#ENSP00000456592#ENSG00000141002#ENST00000565404#Other#$#ENSP00000455471#ENSG00000141002#ENST00000566283#Other#$#ENSP00000456803#ENSG00000141002#ENST00000561958#Other#DUF4604$#ENSP00000456344#ENSG00000141002#ENST00000562193#Other#Tcf25$#ENSP00000456840#ENSG00000141002#ENST00000568409#Other#Tcf25$#ENSP00000457329#ENSG00000141002#ENST00000568412#Other#DUF4604, Tcf25	FALSE
2621	ENSG00000139372	TDG	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	TDG is specific for G/T mispairs in DNA (PDB: 2RBA; PMID: 18587051). Some evidence exists for TDG affecting transcription through interactions with NHR TFs (PMID: 9694815), suggesting it could also be a transcriptional co-factor	IPR003310;IPR005122	6996	thymine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:11700]	2RBA	not tested	not tested	None	DNA error reparing enzyme Human thymine DNA glycosylase (hTDG) removes T from G.T mispairs, producing an abasic (or AP) site	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9694815	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000139372##Other#	FALSE
2622	ENSG00000042088	TDP1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 1NOP)	None	55775	tyrosyl-DNA phosphodiesterase 1	1NOP	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2623	ENSG00000111802	TDP2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds single stranded DNA in the structure (PDB: 4F1H)	None	51567	tyrosyl-DNA phosphodiesterase 2	4F1H	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2624	ENSG00000168769	TET2	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Binds DNA in the crystal structure (PDB: 4NM6). Oxidizes 5-methylcytosine (5mC).	None	54790	tet methylcytosine dioxygenase 2	4NM6	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2625	ENSG00000105329	TGFB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	7040	Transforming growth factor beta-1	None	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF___PMIDS:0	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000105329#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000105329##Other#	FALSE
2626	ENSG00000140682	TGFB1I1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Available evidence suggests that it acts as a co-factor	IPR001781;IPR017305	7041	transforming growth factor beta 1 induced transcript 1 [Source:HGNC Symbol;Acc:HGNC:11767]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:9722648;14755691	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	$##ENSG00000140682##Other#	FALSE
2627	ENSG00000137574	TGS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is an RNA-modifying enzyme (PMID: 19307714)	IPR019012;IPR029063	96764	trimethylguanosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:17843]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11517327;11912212	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$##ENSG00000137574##Other#	FALSE
2628	ENSG00000054118	THRAP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR029199	9967	thyroid hormone receptor associated protein 3 [Source:HGNC Symbol;Acc:HGNC:22964]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:8710870;10198638	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	None	$##ENSG00000054118##Other#	FALSE
2629	ENSG00000151500	THYN1	Unknown	Yes	Likely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure (PDB: 5J3E). Recognizes 5mC containing DNA. Contacts the DNA backbone from the side of the minor groove and has an arginine that inserts into the minor groove.	None	29087	thymocyte nuclear protein 1	5J3E	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	None	None	No	None	None	FALSE
2630	ENSG00000116001	TIA1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Has an RRM domain. Binds single stranded DNA in the structure (PDB: 5ITH)	None	7072	TIA1 cytotoxic granule-associated RNA binding protein	5ITH	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2631	ENSG00000127666	TICAM1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	148022	TIR domain-containing adapter molecule 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000127666#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000127666##Other#	FALSE
2632	ENSG00000163659	TIPARP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000571;IPR004170;IPR012317;	25976	TCDD inducible poly(ADP-ribose) polymerase [Source:HGNC Symbol;Acc:HGNC:23696]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$#ENSP00000295924#ENSG00000163659#ENST00000295924#Other#PARP, WWE$#ENSP00000420612#ENSG00000163659#ENST00000461166#Other#PARP, WWE$#ENSP00000418829#ENSG00000163659#ENST00000481853#Other#PARP, WWE$#ENSP00000420141#ENSG00000163659#ENST00000495891#Other#PARP, WWE$#ENSP00000438345#ENSG00000163659#ENST00000542783#Other#PARP, WWE$#ENSP00000419982#ENSG00000163659#ENST00000473702#Other#WWE	FALSE
2633	ENSG00000150455	TIRAP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000157;IPR017279	114609	toll-interleukin 1 receptor (TIR) domain containing adaptor protein [Source:HGNC Symbol;Acc:HGNC:171	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000150455#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:19509286	$#ENSP00000376445#ENSG00000150455#ENST00000392678#Other#TIR, TIR_2$#ENSP00000376447#ENSG00000150455#ENST00000392680#Other#TIR, TIR_2$#ENSP00000376446#ENSG00000150455#ENST00000392679#Other#TIR, TIR_2	FALSE
2634	ENSG00000196781	TLE1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-factor	IPR001680;IPR005617;IPR009146;IPR017986;IPR019775	7088	transducin like enhancer of split 1 [Source:HGNC Symbol;Acc:HGNC:11837]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9837750	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$##ENSG00000196781##Other#	FALSE
2635	ENSG00000065717	TLE2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001680;IPR005617;IPR009146;IPR017986;IPR019775	7089	transducin like enhancer of split 2 [Source:HGNC Symbol;Acc:HGNC:11838]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:9874198	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Yimeng Yin	No	None	$##ENSG00000065717##Other#	FALSE
2636	ENSG00000140332	TLE3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Protein is a transcriptional co-regulator (PMID: 21459326)	IPR001680;IPR005617;IPR009146;IPR017986;IPR019775	7090	transducin like enhancer of split 3 [Source:HGNC Symbol;Acc:HGNC:11839]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Co-activation_PMIDS:11266540	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$##ENSG00000140332##Other#	FALSE
2637	ENSG00000106829	TLE4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	TLE4 is a Groucho protein (co-repressor)	IPR001680;IPR005617;IPR009146;IPR017986;IPR019775	7091	transducin like enhancer of split 4 [Source:HGNC Symbol;Acc:HGNC:11840]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12153506	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000106829#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000106829##Other#	FALSE
2638	ENSG00000104953	TLE6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor that associates with FOXG1 (PMID: 16314515)	IPR001680;IPR009146;IPR017986	79816	transducin like enhancer of split 6 [Source:HGNC Symbol;Acc:HGNC:30788]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16314515	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$##ENSG00000104953##Other#	FALSE
2639	ENSG00000137462	TLR2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Upstream of NFKB and not involved in DNA-binding	IPR000157;IPR000483;IPR001611;IPR003591;IPR017241	7097	toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	$#ENSG00000137462#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12594207, PMID:21618349	$#ENSP00000260010#ENSG00000137462#ENST00000260010#Other#LRRCT, LRR_1, LRR_4, LRR_5, LRR_8, LRR_9, TIR, TIR	FALSE
2640	ENSG00000164342	TLR3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Binds dsRNA (PMID: 16111635)	None	7098	Toll-like receptor 3	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000164342#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000164342##Other#	FALSE
2641	ENSG00000136869	TLR4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000157;IPR000483;IPR001611;IPR003591;IPR017241;IPR025875	7099	toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000136869#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:12594207	$#ENSP00000363089#ENSG00000136869#ENST00000355622#Other#DUF1863, LRR_1, LRR_4, LRR_6, LRR_8, LRR_9, TIR, T$#ENSP00000377997#ENSG00000136869#ENST00000394487#Other#DUF1863, LRR_1, LRR_4, LRR_6, LRR_8, LRR_9, TIR, T	FALSE
2642	ENSG00000239732	TLR9	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Protein is a nonmethylated CpG dsDNA recognizing protein that operates in the innate immune response to pathogen invasion of the cell. It isnt a TF, but it binds pathogenic DNA (PMID: 11564765). Binds single-stranded DNA in the structure (PDB: 3WPC)	IPR000157;IPR001611;IPR003591	54106	toll like receptor 9 [Source:HGNC Symbol;Acc:HGNC:15633]	3WPC	not tested	not tested	None	None	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Arttu Jolma	Laura Campitelli	No	$#ENSG00000239732#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:17128265$#ENSG00000239732#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:17128265	$#ENSP00000353874#ENSG00000239732#ENST00000360658#Other#LRR_1, LRR_4, LRR_5, LRR_6, LRR_8, LRR_9, TIR	FALSE
2643	ENSG00000204278	TMEM235	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transmembrane protein	IPR004031;IPR006187	283999	transmembrane protein 235 [Source:HGNC Symbol;Acc:HGNC:27563]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	None	$#ENSP00000466793#ENSG00000204278#ENST00000586400#Other#Claudin_2, PMP22_Claudin$#ENSP00000447766#ENSG00000204278#ENST00000550981#Other#Claudin_2, PMP22_Claudin	FALSE
2644	ENSG00000144747	TMF1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	Bacterially-expressed protein binds specifically to the TATA element to compete with TBP, based on EMSA (PMID: 1409643)	IPR022091;IPR022092	7110	TATA element modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:11870]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:1409643;10428808	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	None	$##ENSG00000144747##Other#	FALSE
2645	ENSG00000232810	TNF	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	The protein is a secreted cytokine and operates far upstream in the signaling cascade	IPR002959;IPR006052;IPR006053;IPR008983;IPR021184	7124	tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	None	FALSE
2646	ENSG00000118503	TNFAIP3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Inhibits NFKB-activation. No evidence for direct binding to DNA	IPR002653;IPR003323	7128	TNF alpha induced protein 3 [Source:HGNC Symbol;Acc:HGNC:11896]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000118503#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:18223652	$#ENSP00000237289#ENSG00000118503#ENST00000237289#Other#OTU, zf-A20$#ENSP00000393577#ENSG00000118503#ENST00000421450#Other#$#ENSP00000401562#ENSG00000118503#ENST00000420009#Other#OTU$#ENSP00000409845#ENSG00000118503#ENST00000433680#Other#	FALSE
2647	ENSG00000141655	TNFRSF11A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001368;IPR022323;IPR022361	8792	tumor necrosis factor receptor superfamily member 11a [Source:HGNC Symbol;Acc:HGNC:11908]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Sam Lambert	No	$#ENSG00000141655#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:12296995 | ISS - PMID:19940926$#ENSG00000141655#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:9367155 | IMP - PMID:12296995	$#ENSP00000269485#ENSG00000141655#ENST00000269485#Other#TNFR_c6$#ENSP00000465500#ENSG00000141655#ENST00000586569#Other#TNFR_c6$#ENSP00000479567#ENSG00000141655#ENST00000616710#Other#DAG1, TNFR_c6$#ENSP00000482466#ENSG00000141655#ENST00000617039#Other#DAG1, TNFR_c6	FALSE
2648	ENSG00000186827	TNFRSF4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates far upstream in the signaling cascade	IPR001368;IPR020445	7293	tumor necrosis factor receptor superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11918]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000186827#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000368538#ENSG00000186827#ENST00000379236#Other#TNFR_c6	FALSE
2649	ENSG00000120659	TNFSF11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR006052;IPR008983;IPR017355	8600	tumor necrosis factor superfamily member 11 [Source:HGNC Symbol;Acc:HGNC:11926]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000120659#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - PMID:19940926$#ENSG00000120659#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:9367155	$#ENSP00000351347#ENSG00000120659#ENST00000358545#Other#TNF$#ENSP00000381775#ENSG00000120659#ENST00000398795#Other#TNF$#ENSP00000444913#ENSG00000120659#ENST00000544862#Other#TNF	FALSE
2650	ENSG00000120337	TNFSF18	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a cytokine	IPR006052;IPR008983	8995	tumor necrosis factor superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11932]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	$#ENSG00000120337#GO:0051092#positive regulation of NF-kappaB transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000385470#ENSG00000120337#ENST00000404377#Other#TNF	FALSE
2651	ENSG00000117586	TNFSF4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Extracellular signaling molecule.  Included only because it regulates TFs.	IPR006052;IPR008983;IPR021184	7292	tumor necrosis factor superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11934]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Tim Hughes	No	$#ENSG00000117586#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000281834#ENSG00000117586#ENST00000281834#Other#$#ENSP00000356691#ENSG00000117586#ENST00000367718#Other#	FALSE
2652	ENSG00000160949	TONSL	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds to the N-terminal tail of Histone H4 (PMID: 27338793, PDB: 5JA4).  It is likely a histone chaperone (PMID: 26527279) and thus probably forms nonspecific contacts with DNA.	None	4796	Tonsoku like, DNA repair protein	5JA4	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2653	ENSG00000198900	TOP1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA topoisomerase. Binds DNA in the crystal structure (PDB: 1A31).	None	7150	topoisomerase (DNA) I	1A31	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2654	ENSG00000131747	TOP2A	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA topoisomerase. Binds DNA in the crystal structure (PDB: 4FM9).	None	7153	topoisomerase (DNA) II alpha	4FM9	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2655	ENSG00000077097	TOP2B	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	DNA topoisomerase. Binds DNA in the crystal structure (PDB: 3QX3).	None	7155	topoisomerase (DNA) II beta	3QX3	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2656	ENSG00000197579	TOPORS	Unknown	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None	IPR001841;IPR017907;IPR018957	10210	TOP1 binding arginine/serine rich protein [Source:HGNC Symbol;Acc:HGNC:21653]	None	not tested	not tested	None	None	No	Yes	TF Gene_Single stranded RNA/DNA binding_DNA Binding_PMIDS:11278651;15735665	No	2a1, Lower confidence direct evidence	Pratyush Das	Sam Lambert	No	None	$#ENSP00000353735#ENSG00000197579#ENST00000360538#Other#Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf-$#ENSP00000369187#ENSG00000197579#ENST00000379858#Other#Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf-	FALSE
2657	ENSG00000067369	TP53BP1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Structure PDB:5KGF has just a fragment of TP53BP1 that doesnt contact DNA, but histones	IPR001357;IPR015125	7158	tumor protein p53 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11999]	5KGF	not tested	not tested	None	None	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Pratyush Das	Yimeng Yin	No	$#ENSG00000067369#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IC - PMID:17805299	$#ENSP00000263801#ENSG00000067369#ENST00000263801#Other#53-BP1_Tudor, BRCT, BRCT_2, RTT107_BRCT_5$#ENSP00000371475#ENSG00000067369#ENST00000382044#Other#53-BP1_Tudor, BRCT, BRCT_2, RTT107_BRCT_5$#ENSP00000393497#ENSG00000067369#ENST00000450115#Other#53-BP1_Tudor, BRCT, BRCT_2, RTT107_BRCT_5$#ENSP00000416212#ENSG00000067369#ENST00000434595#Other#$#ENSP00000471624#ENSG00000067369#ENST00000467474#Other#	FALSE
2658	ENSG00000102871	TRADD	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Regulates transcription by binding to the adaptor protein TRAF2, leading to reduction of recruitment of inhibitor-of-apoptosis proteins. No evidence for binding DNA (PMID: 18309324)	IPR000488;IPR009095;IPR011029	8717	TNFRSF1A associated via death domain [Source:HGNC Symbol;Acc:HGNC:12030];Tumor necrosis factor recep	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Tim Hughes	No	$#ENSG00000102871#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - PMID:18309324	$#ENSP00000341268#ENSG00000102871#ENST00000345057#Other#Death, TRADD_N$#ENSP00000462591#ENSG00000102871#ENST00000486556#Other#Death, TRADD_N	FALSE
2659	ENSG00000056558	TRAF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	TRAF1 is an NF-kappaB interactor (PMID: 10692572), and is unlikely to have DNA-binding activity	IPR002083;IPR008974;IPR012227	7185	TNF receptor associated factor 1 [Source:HGNC Symbol;Acc:HGNC:12031]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000056558#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:10692572	$#ENSP00000362994#ENSG00000056558#ENST00000373887#Other#TRAF_BIRC3_bd$#ENSP00000443183#ENSG00000056558#ENST00000540010#Other#TRAF_BIRC3_bd$#ENSP00000438583#ENSG00000056558#ENST00000546084#Other#TRAF_BIRC3_bd	FALSE
2660	ENSG00000127191	TRAF2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Does not contain any canonical DBDs	IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957	7186	TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000127191#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12296995$#ENSG00000127191#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055 | IMP - PMID:12296995, PMID:15	$#ENSP00000247668#ENSG00000127191#ENST00000247668#Other#MATH, Reo_sigmaC, TRAF_BIRC3_bd, zf-C3HC4, zf-C3HC$#ENSP00000397653#ENSG00000127191#ENST00000414589#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-R$#ENSP00000405860#ENSG00000127191#ENST00000419057#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-RING_6$#ENSP00000406524#ENSG00000127191#ENST00000429509#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_4, zf-RING_2, zf-RI	FALSE
2661	ENSG00000131323	TRAF3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957	7187	TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	$#ENSG00000131323#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:20185819	$#ENSP00000332468#ENSG00000131323#ENST00000351691#Other#Fib_alpha, MPS2, Spc7, zf-C3HC4, zf-TRAF$#ENSP00000376500#ENSG00000131323#ENST00000392745#Other#DUF812, MPS2, Spc7, zf-C3HC4, zf-TRAF$#ENSP00000454207#ENSG00000131323#ENST00000560371#Other#DUF812, MPS2, Spc7, zf-C3HC4, zf-TRAF$#ENSP00000445998#ENSG00000131323#ENST00000539721#Other#MPS2, zf-C3HC4, zf-TRAF$#ENSP00000453032#ENSG00000131323#ENST00000559734#Other#ATG16, FliJ, MPS2, Spc29, Spc7, Tropomyosin_1, zf-$#ENSP00000453623#ENSG00000131323#ENST00000560463#Other#zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3HC4_4, zf-H	FALSE
2662	ENSG00000076604	TRAF4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates far upstream in the signaling cascade	IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957	9618	TNF receptor associated factor 4 [Source:HGNC Symbol;Acc:HGNC:12034]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16157600;16157600	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Arttu Jolma	No	None	$##ENSG00000076604##Other#	FALSE
2663	ENSG00000082512	TRAF5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates far upstream in the signaling cascade	IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907;IPR018957	7188	TNF receptor associated factor 5 [Source:HGNC Symbol;Acc:HGNC:12035]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000082512#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12296995$#ENSG00000082512#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:12296995, PMID:15121867	$#ENSP00000261464#ENSG00000082512#ENST00000261464#Other#ATG16, Sina, Spc29, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000355971#ENSG00000082512#ENST00000367004#Other#ATG16, Sina, Spc29, zf-C3HC4, zf-C3HC4_2, zf-C3HC4$#ENSP00000336825#ENSG00000082512#ENST00000336184#Other#ATG16, Sina, Spc29, zf-C3HC4, zf-C3HC4_2, zf-C3HC4	FALSE
2664	ENSG00000175104	TRAF6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001293;IPR001841;IPR002083;IPR008974;IPR012227;IPR017907	7189	TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000175104#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:12296995$#ENSG00000175104#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055, PMID:11751921, PMID:16378096	$#ENSP00000337853#ENSG00000175104#ENST00000348124#Other#SlyX, Tropomyosin_1, U-box, zf-C3HC4, zf-C3HC4_2, $#ENSP00000433623#ENSG00000175104#ENST00000526995#Other#SlyX, Tropomyosin_1, U-box, zf-C3HC4, zf-C3HC4_2,	FALSE
2665	ENSG00000167632	TRAPPC9	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	83696	Trafficking protein particle complex subunit 9	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	$#ENSG00000167632#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000167632##Other#	FALSE
2666	ENSG00000213689	TREX1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Has weak exonuclease activity for GAG, ACA, and CTGC DNA sequences (PMID: 17355961)	None	11277	three prime repair exonuclease 1	2O4I	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2667	ENSG00000173334	TRIB1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Associates with CEBPB and CEBPA and inhibits their activities (PMID: 17724128). This is probably achieved through control of their proteosomal degradation (PMID: 17576771)	IPR000719;IPR002290;IPR011009	10221	tribbles pseudokinase 1 [Source:HGNC Symbol;Acc:HGNC:16891]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Sam Lambert	No	$#ENSG00000173334#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:15299019 | ISS - PMID:17724128	$#ENSP00000312150#ENSG00000173334#ENST00000311922#Other#Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000428879#ENSG00000173334#ENST00000519576#Other#Pkinase, Pkinase_Tyr$#ENSP00000429063#ENSG00000173334#ENST00000520847#Other#Kinase-like, Pkinase, Pkinase_Tyr	FALSE
2668	ENSG00000101255	TRIB3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Disabled kinase - binds NFkappaB and ATF4, but no evidence for direct sequence specific DNA binding.	IPR000719;IPR002290;IPR011009	57761	tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228]	None	not tested	not tested	None	None	No	No	TF Evidence Conflict - There is evidence for and against this genes role as a TF__Other_PMIDS:12749859	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Tim Hughes	No	None	$##ENSG00000101255##Other#	FALSE
2669	ENSG00000204977	TRIM13	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Operates far upstream in the signaling cascade. Ring fingers usually operate in protein-protein interactions	IPR000315;IPR001841;IPR017907;IPR018957	10206	tripartite motif containing 13 [Source:HGNC Symbol;Acc:HGNC:9976]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000204977#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300	$#ENSP00000348299#ENSG00000204977#ENST00000356017#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000367424#ENSG00000204977#ENST00000378182#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000412943#ENSG00000204977#ENST00000420995#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000399206#ENSG00000204977#ENST00000457662#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000367425#ENSG00000204977#ENST00000378183#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H	FALSE
2670	ENSG00000106785	TRIM14	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320	9830	tripartite motif containing 14 [Source:HGNC Symbol;Acc:HGNC:16283]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000106785#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000106785#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300	$#ENSP00000344208#ENSG00000106785#ENST00000341469#Other#PRY, SPRY, zf-B_box$#ENSP00000343990#ENSG00000106785#ENST00000342043#Other#PRY, SPRY, zf-B_box$#ENSP00000364239#ENSG00000106785#ENST00000375098#Other#PRY, SPRY, zf-B_box	FALSE
2671	ENSG00000204610	TRIM15	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907;IPR018957	89870	tripartite motif containing 15 [Source:HGNC Symbol;Acc:HGNC:16284]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Pratyush Das	No	None	None	FALSE
2672	ENSG00000132109	TRIM21	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR001870;IPR003613;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907;IPR020457	6737	tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Sam Lambert	No	$#ENSG00000132109#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:19675099$#ENSG00000132109#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300	$#ENSP00000254436#ENSG00000132109#ENST00000254436#Other#PRY, SPRY, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC$#ENSP00000434053#ENSG00000132109#ENST00000533692#Other#PRY	FALSE
2673	ENSG00000132274	TRIM22	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR013320;IPR017907	10346	tripartite motif containing 22 [Source:HGNC Symbol;Acc:HGNC:16379]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000132274#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7797467$#ENSG00000132274#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000132274#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300	$#ENSP00000369299#ENSG00000132274#ENST00000379965#Other#SPRY, U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3$#ENSP00000409991#ENSG00000132274#ENST00000429063#Other#$#ENSP00000404204#ENSG00000132274#ENST00000444844#Other#$#ENSP00000396849#ENSG00000132274#ENST00000414641#Other#U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3,	FALSE
2674	ENSG00000113595	TRIM23	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR003579;IPR003649;IPR005225;IPR006687;IPR006689;IPR007087;IPR017907;IPR024156;IPR027417;	373	tripartite motif containing 23 [Source:HGNC Symbol;Acc:HGNC:660]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000231524#ENSG00000113595#ENST00000231524#Other#Arf, G-alpha, Gtr1_RagA, MMR_HSR1, Prok-RING_4, Ra$#ENSP00000274327#ENSG00000113595#ENST00000274327#Other#Arf, G-alpha, Gtr1_RagA, MMR_HSR1, Prok-RING_4, Ra$#ENSP00000370406#ENSG00000113595#ENST00000381018#Other#Arf, G-alpha, Gtr1_RagA, MMR_HSR1, Prok-RING_4, Ra$#ENSP00000422144#ENSG00000113595#ENST00000513794#Other#	FALSE
2675	ENSG00000122779	TRIM24	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Known cofactor. Included because TF-CAT documents this.  Does not have any canonical DBDs.	IPR000315;IPR001487;IPR001841;IPR001965;IPR003649;IPR011011;IPR017907;IPR018359;IPR019786;IPR019787	8805	tripartite motif containing 24 [Source:HGNC Symbol;Acc:HGNC:11812]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:8978696;10598587	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	None	$##ENSG00000122779##Other#	FALSE
2676	ENSG00000121060	TRIM25	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907	100500827	tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932];E3 ubiquitin/ISG15 ligase TRIM25	None	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF__Other_PMIDS:12943693	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Jussi Taipale	No	$#ENSG00000121060#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8248217$#ENSG00000121060#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000121060#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300	$#ENSP00000323889#ENSG00000121060#ENST00000316881#Other#PRY, Prok-RING_4, SPRY, zf-B_box, zf-C3HC4, zf-C3H$#ENSP00000445961#ENSG00000121060#ENST00000537230#Other#PRY, Prok-RING_4, SPRY, zf-B_box, zf-C3HC4, zf-C3H	FALSE
2677	ENSG00000234127	TRIM26	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR020457	7726	tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	None	FALSE
2678	ENSG00000204713	TRIM27	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Evidence presented in (PMID: 1437549) for DNA-binding of alias RFP is not strong - if anything, this is likely a non-specific DNA binder	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907;IPR020457	5987	tripartite motif containing 27 [Source:HGNC Symbol;Acc:HGNC:9975];Zinc finger protein RFP	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	None	None	FALSE
2679	ENSG00000130726	TRIM28	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	This protein a well-known co-repressor and is recruited to DNA by KRAB-domain containing TFs. Transfac motifs are likely from interacting proteins	IPR000315;IPR001487;IPR001841;IPR001965;IPR003649;IPR011011;IPR019786;IPR019787	10155	tripartite motif containing 28 [Source:HGNC Symbol;Acc:HGNC:16384];Transcription intermediary factor	None	not tested	not tested	None	None	No	Yes	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:8986806	Yes	2a1, Lower confidence direct evidence	Yimeng Yin	Sam Lambert	No	$#ENSG00000130726#GO:0003700#sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000253024#ENSG00000130726#ENST00000253024#Other#PHD, PHD_2, zf-B_box, zf-C3HC4, zf-RING_2, zf-RING$#ENSP00000342232#ENSG00000130726#ENST00000341753#Other#PHD, PHD_2, zf-B_box, zf-C3HC4, zf-RING_2, zf-RING$#ENSP00000471303#ENSG00000130726#ENST00000597136#Other#PHD, PHD_2$#ENSP00000470503#ENSG00000130726#ENST00000597968#Other#zf-B_box$#ENSP00000472586#ENSG00000130726#ENST00000593582#Other#zf-B_box	FALSE
2680	ENSG00000137699	TRIM29	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Previous evidence for TF activity (PMID: 8188213) is based on sequence analysis and does not provide DNA-binding evidence. Based on EntrezGene information, its likely a transcriptional co-factor	IPR000315	23650	tripartite motif containing 29 [Source:HGNC Symbol;Acc:HGNC:17274]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000137699#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:8188213	$#ENSP00000343129#ENSG00000137699#ENST00000341846#Other#zf-B_box$#ENSP00000435696#ENSG00000137699#ENST00000528870#Other#$#ENSP00000436015#ENSG00000137699#ENST00000529044#Other#Med4$#ENSP00000436279#ENSG00000137699#ENST00000526881#Other#	FALSE
2681	ENSG00000110171	TRIM3	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains multiple NHL domains, which bind RNA (see, for example, LRP8).	IPR000315;IPR001258;IPR001298;IPR001841;IPR003649;IPR013017;IPR014756;IPR017868;IPR017907;IPR018957	10612	tripartite motif containing 3 [Source:HGNC Symbol;Acc:HGNC:10064]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Tim Hughes	No	None	$#ENSP00000340797#ENSG00000110171#ENST00000345851#Other#DUF4934, DUF5128, Filamin, NHL, Prok-RING_4, SBBP,$#ENSP00000433102#ENSG00000110171#ENST00000525074#Other#DUF4934, DUF5128, Filamin, NHL, Prok-RING_4, SBBP,$#ENSP00000445460#ENSG00000110171#ENST00000536344#Other#DUF4934, DUF5128, Filamin, NHL, SBBP, SGL, zf-B_bo$#ENSP00000437283#ENSG00000110171#ENST00000529529#Other#Prok-RING_4, zf-ANAPC11, zf-C3HC4, zf-C3HC4_2, zf-	FALSE
2682	ENSG00000204616	TRIM31	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR017907;IPR020457	11074	tripartite motif containing 31 [Source:HGNC Symbol;Acc:HGNC:16289];E3 ubiquitin-protein ligase TRIM31	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	None	None	FALSE
2683	ENSG00000119401	TRIM32	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001258;IPR001841;IPR013017;IPR017907;IPR027370	22954	tripartite motif containing 32 [Source:HGNC Symbol;Acc:HGNC:16380]	None	not tested	not tested	None	None	x	No	No	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000119401#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000119401#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300 | ISS - GO_REF:0000024	$#ENSP00000363095#ENSG00000119401#ENST00000373983#Other#Baculo_IE-1, NHL, Prok-RING_4, SGL, zf-B_box, zf-C$#ENSP00000408292#ENSG00000119401#ENST00000450136#Other#Baculo_IE-1, NHL, Prok-RING_4, SGL, zf-B_box, zf-C$#ENSP00000412603#ENSG00000119401#ENST00000411410#Other#Baculo_IE-1, FYVE, Prok-RING_4, Zn_Tnp_IS1595, zf-	FALSE
2684	ENSG00000197323	TRIM33	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001487;IPR001841;IPR001965;IPR003649;IPR011011;IPR017907;IPR019786;IPR019787	51592	tripartite motif containing 33 [Source:HGNC Symbol;Acc:HGNC:16290]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10022127;12096914	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	None	$##ENSG00000197323##Other#	FALSE
2685	ENSG00000258659	TRIM34	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR013320;IPR017907	53840	tripartite motif containing 34 [Source:HGNC Symbol;Acc:HGNC:10063]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Jussi Taipale	No	$#ENSG00000258659#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300	$#ENSP00000402595#ENSG00000258659#ENST00000429814#Other#SPRY, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, $#ENSP00000422947#ENSG00000258659#ENST00000514226#Other#SPRY, zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3,	FALSE
2686	ENSG00000108395	TRIM37	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says it is a regulator of NFkappaB.  No evidence for DNA binding, and no canonical DBD.	IPR000315;IPR001841;IPR002083;IPR003649;IPR008974	4591	tripartite motif containing 37 [Source:HGNC Symbol;Acc:HGNC:7523]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000108395#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055$#ENSG00000108395#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000108395#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300	$#ENSP00000262294#ENSG00000108395#ENST00000262294#Other#MATH, zf-B_box, zf-C3HC4_2, zf-C3HC4_3$#ENSP00000376785#ENSG00000108395#ENST00000393066#Other#MATH, zf-B_box, zf-C3HC4_2, zf-C3HC4_3$#ENSP00000376784#ENSG00000108395#ENST00000393065#Other#MATH, zf-B_box$#ENSP00000464263#ENSG00000108395#ENST00000584889#Other#zf-C3HC4_2, zf-C3HC4_3, zf-RING_2$#ENSP00000462778#ENSG00000108395#ENST00000583945#Other#	FALSE
2687	ENSG00000112343	TRIM38	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907	10475	tripartite motif containing 38 [Source:HGNC Symbol;Acc:HGNC:10059]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000112343#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000112343#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300	$#ENSP00000349596#ENSG00000112343#ENST00000357085#Other#PRY, SPRY, U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2,	FALSE
2688	ENSG00000204614	TRIM40	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein that promotes post-translational modification of an NBKB-inhibitor protein (PMID: 21474709)	IPR000315;IPR001841;IPR017907	135644	tripartite motif containing 40 [Source:HGNC Symbol;Acc:HGNC:18736]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	None	FALSE
2689	ENSG00000132256	TRIM5	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBD and no evidence for DNA binding.  Included as a candidate only because GO says its a regulator.	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR013320;IPR017907	85363	tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Laura Campitelli	No	$#ENSG00000132256#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000132256#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:21512573, PMID:23077300	$#ENSP00000380058#ENSG00000132256#ENST00000396847#Other#FAM76, TMF_TATA_bd, U-box, zf-B_box, zf-C3HC4, zf-$#ENSP00000388031#ENSG00000132256#ENST00000412903#Other#TMF_TATA_bd, U-box, zf-B_box, zf-C3HC4, zf-C3HC4_2$#ENSP00000369373#ENSG00000132256#ENST00000380034#Other#FAM76, SPRY, TMF_TATA_bd, U-box, zf-B_box, zf-C3HC$#ENSP00000398196#ENSG00000132256#ENST00000438025#Other#TMF_TATA_bd	FALSE
2690	ENSG00000183718	TRIM52	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Established ubiquitin ligase that targets at least one viral protein (NS2A) of Japanese Encephalitis Virus to proteosomal degradation (PMID: 27667714)	IPR000315;IPR001841;IPR017907	84851	tripartite motif containing 52 [Source:HGNC Symbol;Acc:HGNC:19024]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Jussi Taipale	No	$#ENSG00000183718#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300	$#ENSP00000483005#ENSG00000183718#ENST00000611618#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H	FALSE
2691	ENSG00000116525	TRIM62	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a ubiguitin ligase (PMID: 23402750)	IPR000315;IPR001841;IPR001870;IPR003877;IPR003879;IPR006574;IPR013320;IPR017907	55223	tripartite motif containing 62 [Source:HGNC Symbol;Acc:HGNC:25574];E3 ubiquitin-protein ligase TRIM6	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000116525#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IMP - PMID:23077300$#ENSG00000116525#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:23077300	$#ENSP00000291416#ENSG00000116525#ENST00000291416#Other#AAA_13, CorA, DUF3416, KxDL, PRY, SPRY, zf-B_box, $#ENSP00000441173#ENSG00000116525#ENST00000543586#Other#Fib_alpha, LXG, PRY, SPRY	FALSE
2692	ENSG00000171206	TRIM8	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001841;IPR017907	81603	tripartite motif containing 8 [Source:HGNC Symbol;Acc:HGNC:15579]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	No	$#ENSG00000171206#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:23077300$#ENSG00000171206#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:23077300	$#ENSP00000302120#ENSG00000171206#ENST00000302424#Other#zf-B_box, zf-C3HC4, zf-C3HC4_2, zf-C3HC4_3, zf-C3H$#ENSP00000473428#ENSG00000171206#ENST00000462202#Other#zf-B_box	FALSE
2693	ENSG00000100815	TRIP11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Structural component of the Golgi-apparatus (PMID: 19112494)	IPR000237	9321	thyroid hormone receptor interactor 11 [Source:HGNC Symbol;Acc:HGNC:12305]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9256431	No	5a, one of the source datasets predicts is as a TF	Tim Hughes	Arttu Jolma	No	None	$##ENSG00000100815##Other#	FALSE
2694	ENSG00000043514	TRIT1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Protein is a tRNA modifying enzyme (PMID: 15870694)	IPR003604;IPR018022;IPR022755;IPR027417	54802	tRNA isopentenyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:20286]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000321810#ENSG00000043514#ENST00000316891#Other#AAA_16, AAA_18, AAA_28, AAA_33, IPPT, IPT, zf-C2H2$#ENSP00000361905#ENSG00000043514#ENST00000372818#Other#AAA_16, AAA_18, AAA_28, AAA_33, IPPT, IPT, zf-C2H2$#ENSP00000388333#ENSG00000043514#ENST00000441669#Other#AAA_16, AAA_18, AAA_22, AAA_25, AAA_28, AAA_33, AB$#ENSP00000437896#ENSG00000043514#ENST00000541099#Other#zf-C2H2_jaz, zf-met	FALSE
2695	ENSG00000121486	TRMT1L	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR002905;IPR007087;IPR015880;IPR029063	81627	tRNA methyltransferase 1 like [Source:HGNC Symbol;Acc:HGNC:16782]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000356476#ENSG00000121486#ENST00000367506#Other#Met_10, Methyltransf_25, Methyltransf_31, TRM$#ENSP00000414339#ENSG00000121486#ENST00000458395#Other#TRM	FALSE
2696	ENSG00000196367	TRRAP	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a component of histone acetyltransferase complexes	IPR000403;IPR003151;IPR003152;IPR011009;IPR014009;IPR016024	8295	transformation/transcription domain associated protein [Source:HGNC Symbol;Acc:HGNC:12347]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9708738	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Arttu Jolma	No	None	$##ENSG00000196367##Other#	FALSE
2697	ENSG00000103197	TSC2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000331;IPR003913;IPR016024;IPR018515;IPR024584	7249	tuberous sclerosis 2 [Source:HGNC Symbol;Acc:HGNC:12363]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:15249583	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	None	$##ENSG00000103197##Other#	FALSE
2698	ENSG00000102804	TSC22D1	Unknown	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	TSC22D1 appears to homo- and heterodimerize with other TFs to affect transcription (PMID: 10488076). In vitro, it has been shown to bind GC-rich DNA sequences (PMID: 9022669)	IPR000580;	8848	TSC22 domain family member 1 [Source:HGNC Symbol;Acc:HGNC:16826]	None	not tested	not tested	None	None	a	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:10488076	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000102804#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000261489#ENSG00000102804#ENST00000261489#Other#DUF972, DivIC, SOGA, TSC22, ZapB$#ENSP00000397435#ENSG00000102804#ENST00000458659#Other#DUF972, K-box, TSC22$#ENSP00000437414#ENSG00000102804#ENST00000501704#Other#SUIM_assoc$#ENSP00000481585#ENSG00000102804#ENST00000611198#Other#DUF972, DivIC, SOGA, TSC22, ZapB$#ENSP00000483407#ENSG00000102804#ENST00000622051#Other#DUF972, DivIC, SOGA, TSC22, ZapB	FALSE
2699	ENSG00000196428	TSC22D2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF.	IPR000580;	9819	TSC22 domain family member 2 [Source:HGNC Symbol;Acc:HGNC:29095]	None	not tested	not tested	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Jussi Taipale	Yes	$#ENSG00000196428#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000354543#ENSG00000196428#ENST00000361875#Other#TSC22$#ENSP00000417747#ENSG00000196428#ENST00000466814#Other#DUF972, K-box, TSC22, ZapB$#ENSP00000418149#ENSG00000196428#ENST00000480589#Other#	FALSE
2700	ENSG00000157514	TSC22D3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF.	IPR000580;	1831	TSC22 domain family member 3 [Source:HGNC Symbol;Acc:HGNC:3051]	None	DBD	not tested	None	None	a	No	Probably Not a TF - No evidence that it is a TF___PMIDS:0	Yes	4a, two or more datasets predict it as a TF	Jussi Taipale	Matt Weirauch	Yes	$#ENSG00000157514#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000314655#ENSG00000157514#ENST00000315660#Other#DUF972, DivIC, NPV_P10, TSC22, ZapB$#ENSP00000361466#ENSG00000157514#ENST00000372390#Other#DUF972, DivIC, Lebercilin, NPV_P10, TSC22, ZapB$#ENSP00000361474#ENSG00000157514#ENST00000372397#Other#DUF972, DivIC, K-box, NPV_P10, TSC22, ZapB$#ENSP00000361458#ENSG00000157514#ENST00000372383#Other#DUF972, DivIC, NPV_P10, TSC22, ZapB$#ENSP00000361459#ENSG00000157514#ENST00000372384#Other#DUF972, DivIC, NPV_P10, TSC22, ZapB$#ENSP00000425414#ENSG00000157514#ENST00000486554#Other#TSC22$#ENSP00000422060#ENSG00000157514#ENST00000503515#Other#$#ENSP00000361457#ENSG00000157514#ENST00000372382#Other#DUF972, DivIC, K-box, NPV_P10, TSC22, ZapB$#ENSP00000425158#ENSG00000157514#ENST00000505965#Other#	FALSE
2701	ENSG00000166925	TSC22D4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF.	IPR000580;	81628	TSC22 domain family member 4 [Source:HGNC Symbol;Acc:HGNC:21696]	None	DBD	not tested	None	None	b	No	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	Yes	$#ENSG00000166925#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000300181#ENSG00000166925#ENST00000300181#Other#DUF972, TSC22$#ENSP00000377560#ENSG00000166925#ENST00000393991#Other#DUF972, DivIC, K-box, TSC22, ZapB$#ENSP00000388168#ENSG00000166925#ENST00000423266#Other#DUF972, K-box, TSC22, ZapB$#ENSP00000395795#ENSG00000166925#ENST00000456330#Other#	FALSE
2702	ENSG00000211460	TSN	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Based on (PMID: 20450889) and (PMID: 12484770), this protein binds repetitive DNA sequences as multimeric complexes that may contain partner protein TSNAX	IPR002848	7247	translin [Source:HGNC Symbol;Acc:HGNC:12379]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:9159125;10434033	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	None	$##ENSG00000211460##Other#	FALSE
2703	ENSG00000139908	TSSK4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000719;IPR002290;IPR008271;IPR011009;IPR017441	283629	testis specific serine kinase 4 [Source:HGNC Symbol;Acc:HGNC:19825]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000139908#GO:0032793#positive regulation of CREB transcription factor activity#IDA - PMID:15964553	$#ENSP00000287913#ENSG00000139908#ENST00000287913#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000452054#ENSG00000139908#ENST00000556621#Other#APH, Kdo, Kinase-like, Pkinase, Pkinase_Tyr$#ENSP00000339179#ENSG00000139908#ENST00000339917#Other#Pkinase, Pkinase_Tyr$#ENSP00000412180#ENSG00000139908#ENST00000428351#Other#Pkinase, Pkinase_Tyr$#ENSP00000450752#ENSG00000139908#ENST00000553766#Other#Pkinase, Pkinase_Tyr	FALSE
2704	ENSG00000166402	TUB	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	The Tubby C-terminal domain (IPR000007; PF01167) has been shown to impart nuclear localization and bind select dsDNA sequences in gel-shift experiments (PMID: 10591637). This article hypothesized that this domain constitutes a bona fide sequence specific TF, but no concrete evidence for this exists to date	IPR000007;IPR005398;IPR018066;IPR025659	7275	tubby bipartite transcription factor [Source:HGNC Symbol;Acc:HGNC:12406]	None	not tested	not tested	None	None	other	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000299506#ENSG00000166402#ENST00000299506#Other#Tub, Tub_N$#ENSP00000305426#ENSG00000166402#ENST00000305253#Other#Tub, Tub_N$#ENSP00000434400#ENSG00000166402#ENST00000534099#Other#Tub, Tub_N	FALSE
2705	ENSG00000130338	TULP4	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	(PMID: 10591637) shows that it binds dsDNA.  All other research, however, supports phosphoinositide-binding as the major function of the tubby domain.	IPR000007;IPR001496;IPR001680;IPR008983;IPR017986;IPR025659	56995	tubby like protein 4 [Source:HGNC Symbol;Acc:HGNC:15530]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Matt Weirauch	No	$#ENSG00000130338#GO:0003700#sequence-specific DNA binding transcription factor activity#NAS - PMID:11595174	$#ENSP00000356061#ENSG00000130338#ENST00000367094#Other#ANAPC4_WD40, SOCS_box, Tub$#ENSP00000356064#ENSG00000130338#ENST00000367097#Other#ANAPC4_WD40, SOCS_box, Tub	FALSE
2706	ENSG00000149016	TUT1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	None	IPR000504;IPR002058	64852	terminal uridylyl transferase 1, U6 snRNA-specific [Source:HGNC Symbol;Acc:HGNC:26184]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000308000#ENSG00000149016#ENST00000308436#Other#PAP_assoc, zf-met$#ENSP00000419607#ENSG00000149016#ENST00000476907#Other#PAP_assoc, zf-met$#ENSP00000420739#ENSG00000149016#ENST00000494385#Other#$#ENSP00000278279#ENSG00000149016#ENST00000278279#Other#zf-met	FALSE
2707	ENSG00000074966	TXK	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Experimental evidence for DNA-binding was performed with nuclear extract - thus, the apparent specific-binding of TXK could be due to indirect binding (PMID: 11859127). In addition a whitepaper suggests that this interaction could not be replicated (Miskimins, Beth)	IPR000719;IPR000980;IPR001245;IPR001452;IPR008266;IPR011009;IPR017441;IPR020635	7294	TXK tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12434]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:11859127	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000074966#GO:0001077#RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a#IDA - PMID:11859127	$#ENSP00000264316#ENSG00000074966#ENST00000264316#Other#Pkinase, Pkinase_Tyr, SH2, SH3_1, SH3_9$#ENSP00000423481#ENSG00000074966#ENST00000507351#Other#Pkinase, Pkinase_Tyr$#ENSP00000422798#ENSG00000074966#ENST00000506073#Other#SH3_1, SH3_9	FALSE
2708	ENSG00000160201	U2AF1	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Well-established RNA binding protein	IPR000504;IPR000571;IPR003954;IPR009145	102724594	U2 small nuclear RNA auxiliary factor 1 [Source:HGNC Symbol;Acc:HGNC:12453]	None	Full	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000291552#ENSG00000160201#ENST00000291552#Other#$#ENSP00000369629#ENSG00000160201#ENST00000380276#Other#$#ENSP00000381205#ENSG00000160201#ENST00000398137#Other#$#ENSP00000418705#ENSG00000160201#ENST00000459639#Other#	FALSE
2709	ENSG00000161265	U2AF1L4	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Related to U2AF1, so likely also an RNA binding protein.	IPR000504;IPR000571;IPR003954;IPR009145	199746	U2 small nuclear RNA auxiliary factor 1-like 4 [Source:HGNC Symbol;Acc:HGNC:23020]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000292879#ENSG00000161265#ENST00000292879#Other#$#ENSP00000368258#ENSG00000161265#ENST00000378975#Other#$#ENSP00000467441#ENSG00000161265#ENST00000587886#Other#$#ENSP00000397645#ENSG00000161265#ENST00000412391#Other#	FALSE
2710	ENSG00000221983	UBA52	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000626;IPR001975;IPR011332;IPR019954;IPR019956;IPR029071	7311	ubiquitin A-52 residue ribosomal protein fusion product 1 [Source:HGNC Symbol;Acc:HGNC:12458]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Pratyush Das	No	$#ENSG00000221983#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000396910#ENSG00000221983#ENST00000430157#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000388107#ENSG00000221983#ENST00000442744#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000473048#ENSG00000221983#ENST00000597451#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000470419#ENSG00000221983#ENST00000595683#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000472768#ENSG00000221983#ENST00000596272#Other#Rad60-SLD, Ribosomal_L40e, Ubiquitin_2, ubiquitin$#ENSP00000471062#ENSG00000221983#ENST00000596273#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000472137#ENSG00000221983#ENST00000599256#Other#Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiquitin$#ENSP00000470507#ENSG00000221983#ENST00000599551#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000471991#ENSG00000221983#ENST00000594527#Other#Rad60-SLD, Ribosomal_L40e, ubiquitin$#ENSP00000471622#ENSG00000221983#ENST00000595158#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000472545#ENSG00000221983#ENST00000598780#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_$#ENSP00000471464#ENSG00000221983#ENST00000599595#Other#Rad60-SLD, Rad60-SLD_2, Ribosomal_L40e, Ubiquitin_	FALSE
2711	ENSG00000170315	UBB	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000626;IPR019954;IPR019956;IPR029071	7314	ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463];Polyubiquitin-B	4ZUX	not tested	not tested	None	None	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Arttu Jolma	Jussi Taipale	No	$#ENSG00000170315#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000304697#ENSG00000170315#ENST00000302182#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S$#ENSP00000379178#ENSG00000170315#ENST00000395837#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S$#ENSP00000379180#ENSG00000170315#ENST00000395839#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S$#ENSP00000437475#ENSG00000170315#ENST00000535788#Other#DUF2407, DUF2870, FERM_f0, Rad60-SLD, Rad60-SLD_2,$#ENSP00000464594#ENSG00000170315#ENST00000577958#Other#Rad60-SLD, Ubiquitin_2, ubiquitin$#ENSP00000464510#ENSG00000170315#ENST00000578706#Other#Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiquitin$#ENSP00000478771#ENSG00000170315#ENST00000614404#Other#DUF2407, DUF2870, DUF969, Methyltrans_RNA, Rad60-S	FALSE
2712	ENSG00000150991	UBC	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000626;IPR019954;IPR019956;IPR029071	7316	ubiquitin C [Source:HGNC Symbol;Acc:HGNC:12468];Polyubiquitin-C	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Arttu Jolma	No	$#ENSG00000150991#GO:0051092#positive regulation of NF-kappaB transcription factor activity#TAS - Reactome:R-HSA-445989	$#ENSP00000344818#ENSG00000150991#ENST00000339647#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiq$#ENSP00000442800#ENSG00000150991#ENST00000540351#Other#DUF2407, DUF2870, FERM_f0, Rad60-SLD, Rad60-SLD_2,$#ENSP00000437452#ENSG00000150991#ENST00000535859#Other#Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiquitin$#ENSP00000441238#ENSG00000150991#ENST00000540700#Other#DUF2407, RBD, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2,$#ENSP00000445337#ENSG00000150991#ENST00000541645#Other#DUF2407, DUF2870, FERM_f0, Rad60-SLD, Rad60-SLD_2,$#ENSP00000441543#ENSG00000150991#ENST00000536769#Other#DUF2407, Rad60-SLD, Rad60-SLD_2, Ubiquitin_2, ubiq	FALSE
2713	ENSG00000078140	UBE2K	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000449;IPR000608;IPR009060;IPR015940;IPR016135;IPR023313	3093	ubiquitin conjugating enzyme E2 K [Source:HGNC Symbol;Acc:HGNC:4914]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Matt Weirauch	No	None	$#ENSP00000261427#ENSG00000078140#ENST00000261427#Other#Prok-E2_B, RWD, UBA, UQ_con$#ENSP00000390483#ENSG00000078140#ENST00000445950#Other#Prok-E2_B, RWD, UQ_con$#ENSP00000421203#ENSG00000078140#ENST00000503368#Other#UBA, UQ_con$#ENSP00000425301#ENSG00000078140#ENST00000510934#Other#UBA, UQ_con	FALSE
2714	ENSG00000177889	UBE2N	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000608;IPR016135;IPR023313	7334	ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000177889#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:14695475, PMID:16129784	$#ENSP00000316176#ENSG00000177889#ENST00000318066#Other#Prok-E2_B, UEV, UQ_con$#ENSP00000449352#ENSG00000177889#ENST00000550657#Other#UQ_con$#ENSP00000450260#ENSG00000177889#ENST00000549833#Other#UQ_con$#ENSP00000448352#ENSG00000177889#ENST00000552442#Other#UQ_con	FALSE
2715	ENSG00000244687	UBE2V1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Ubiquitin ligase	IPR000608;IPR016135	7335	ubiquitin conjugating enzyme E2 V1 [Source:HGNC Symbol;Acc:HGNC:12494]	None	not tested	Yes	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000244687#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IMP - PMID:16129784	$#ENSP00000340305#ENSG00000244687#ENST00000340309#Other#UQ_con$#ENSP00000360739#ENSG00000244687#ENST00000371674#Other#UQ_con$#ENSP00000407770#ENSG00000244687#ENST00000415862#Other#UQ_con$#ENSP00000360742#ENSG00000244687#ENST00000371677#Other#UQ_con	FALSE
2716	ENSG00000118900	UBN1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Interacts with bZIP transcription factors (PMID: 10725330)	IPR014840;IPR026947	29855	ubinuclein 1 [Source:HGNC Symbol;Acc:HGNC:12506]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Yimeng Yin	No	$#ENSG00000118900#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:10725330	$#ENSP00000262376#ENSG00000118900#ENST00000262376#Other#HUN, UBN_AB$#ENSP00000379894#ENSG00000118900#ENST00000396658#Other#HUN, UBN_AB$#ENSP00000468740#ENSG00000118900#ENST00000590769#Other#HUN, UBN_AB$#ENSP00000467942#ENSG00000118900#ENST00000592120#Other#HUN$#ENSP00000465309#ENSG00000118900#ENST00000586716#Other#UBN_AB	FALSE
2717	ENSG00000127481	UBR4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003126;IPR013993;IPR016024;IPR017986;IPR025704;	23352	ubiquitin protein ligase E3 component n-recognin 4 [Source:HGNC Symbol;Acc:HGNC:30313]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	None	$#ENSP00000364403#ENSG00000127481#ENST00000375254#Other#E3_UbLigase_R4, zf-UBR$#ENSP00000364366#ENSG00000127481#ENST00000375218#Other#DZR$#ENSP00000364372#ENSG00000127481#ENST00000375224#Other#E3_UbLigase_R4$#ENSP00000364373#ENSG00000127481#ENST00000375225#Other#E3_UbLigase_R4$#ENSP00000395313#ENSG00000127481#ENST00000425413#Other#	FALSE
2718	ENSG00000228970	UBTFL6	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	According to ENSEMBL this is a Pseudogene, and it is of uncertain confidence in Uniprot. The most similar gene, UBTLF1, is annotated as No evidence for or against specific DNA-binding by this class of HMG box containing proteins.	None	Has no Entrez identifier	Upstream binding transcription factor, RNA polymerase I-like 6 (pseudogene)	None	not tested	not tested	None	None	No	No	No	No	New proteins added after initial stage	Arttu Jolma	Sam Lambert	Yes	None	None	FALSE
2719	ENSG00000014123	UFL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR018611	23376	UFM1 specific ligase 1 [Source:HGNC Symbol;Acc:HGNC:23039]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Matt Weirauch	No	$#ENSG00000014123#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IMP - PMID:20164180, PMID:20228063	$#ENSP00000358283#ENSG00000014123#ENST00000369278#Other#DUF2042	FALSE
2720	ENSG00000276043	UHRF1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Structural evidence (PDB:2ZO0; PDB: 2ZO1; PMID: 18772888] and (PDB: 2ZKE) (PMID: 18772891) demonstrate direct DNA-binding. However, the extent to which it is sequence specific beyond hemimethylated DNA has not been extensively explored.	IPR000626;IPR001841;IPR001965;IPR003105;IPR011011;IPR015947;IPR017907;IPR019787;IPR021991;IPR029071	29128	ubiquitin like with PHD and ring finger domains 1 [Source:HGNC Symbol;Acc:HGNC:12556]	2ZO2	not tested	not tested	None	None	No	No	No	Yes	3a, decent circumstantial evidence for its role as	Jussi Taipale	Sam Lambert	No	$#ENSG00000276043#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:1868030	$#ENSP00000484739#ENSG00000276043#ENST00000612630#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000478348#ENSG00000276043#ENST00000616255#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000478171#ENSG00000276043#ENST00000620565#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000479617#ENSG00000276043#ENST00000622802#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000485604#ENSG00000276043#ENST00000624301#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD, $#ENSP00000480214#ENSG00000276043#ENST00000613817#Other#Prok-RING_4, SAD_SRA, zf-C3HC4, zf-C3HC4_2, zf-C3H$#ENSP00000478601#ENSG00000276043#ENST00000615884#Other#PHD, PHD_2, Prok-RING_4, Rad60-SLD, SAD_SRA, TTD,	FALSE
2721	ENSG00000147854	UHRF2	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds DNA in the crystal structure contacting the minor groove and backbone (PDB: 4PW5).  Recognizes 5hmC-containing DNA (PDB: 4PW5)	None	115426	ubiquitin like with PHD and ring finger domains 2	4PW5	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2722	ENSG00000076248	UNG	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Involved in mismatch repair. Excises uracil bases from DNA. Binds DNA in the crystal structure (PDB: 1EMJ)	None	7374	uracil DNA glycosylase	1EMJ	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2723	ENSG00000168883	USP39	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001394;IPR001607;IPR028889;	10713	ubiquitin specific peptidase 39 [Source:HGNC Symbol;Acc:HGNC:20071]	None	not tested	Yes	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	No	None	$#ENSP00000312981#ENSG00000168883#ENST00000323701#Other#UCH, UCH_1, zf-UBP$#ENSP00000386864#ENSG00000168883#ENST00000409470#Other#UCH, UCH_1, zf-UBP$#ENSP00000386803#ENSG00000168883#ENST00000409766#Other#UCH, UCH_1, zf-UBP$#ENSP00000396133#ENSG00000168883#ENST00000450066#Other#UCH, UCH_1, zf-UBP$#ENSP00000484024#ENSG00000168883#ENST00000613444#Other#UCH, UCH_1, zf-UBP$#ENSP00000396854#ENSG00000168883#ENST00000448971#Other#zf-UBP	FALSE
2724	ENSG00000187555	USP7	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001394;IPR002083;IPR008974;IPR018200;IPR024729;IPR028889;IPR029346	7874	ubiquitin specific peptidase 7 (herpes virus-associated) [Source:HGNC Symbol;Acc:HGNC:12630]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Jussi Taipale	No	$#ENSG00000187555#GO:0032088#negative regulation of NF-kappaB transcription factor activity#IDA - PMID:11279055$#ENSG00000187555#GO:0051090#regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:16964248	$#ENSP00000343535#ENSG00000187555#ENST00000344836#Other#MATH, UCH, UCH_1, USP7_C2, USP7_ICP0_bdg$#ENSP00000371310#ENSG00000187555#ENST00000381886#Other#MATH, UCH, UCH_1, USP7_C2, USP7_ICP0_bdg$#ENSP00000454795#ENSG00000187555#ENST00000563085#Other#MATH, UCH, UCH_1, USP7_C2, USP7_ICP0_bdg	FALSE
2725	ENSG00000171794	UTF1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	8433	undifferentiated embryonic cell transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12634]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9524124	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Yimeng Yin	Yes	None	$##ENSG00000171794##Other#	FALSE
2726	ENSG00000141968	VAV1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Paper cited by GO annotation (PMID: 2477241) only presents evidence based on sequence similarity to a ZF motif, and other evidence (PMID: 11994417) only supports a role in coactivation of NFAT and NFKB without direct DNA-binding	IPR000219;IPR000980;IPR001331;IPR001452;IPR001715;IPR001849;IPR002219;IPR003096;IPR022613	7409	vav guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:12657]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__TF PPI; Transactivation_PMIDS:11994417	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Yimeng Yin	No	$#ENSG00000141968#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:2477241	$#ENSP00000302269#ENSG00000141968#ENST00000304076#Other#C1_1, C1_2, CAMSAP_CH, CDC24, CH, PH, RhoGEF, SH2,$#ENSP00000472803#ENSG00000141968#ENST00000599806#Other#C1_1, C1_2, CAMSAP_CH, CH, PH, RhoGEF, SH2, SH3_1,$#ENSP00000472929#ENSG00000141968#ENST00000602142#Other#C1_1, C1_2, CAMSAP_CH, CDC24, CH, PH, RhoGEF, SH2,$#ENSP00000469450#ENSG00000141968#ENST00000596764#Other#C1_1, C1_2, CAMSAP_CH, CDC24, CH, PH, RhoGEF, SH2,	FALSE
2727	ENSG00000112715	VEGFA	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Extracellular signaling molecule.  Included only because it regulates CREB.	IPR000072;IPR023581;IPR027928;IPR029034	7422	vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Pratyush Das	No	$#ENSG00000112715#GO:0032793#positive regulation of CREB transcription factor activity#IDA - PMID:20497126	$#ENSP00000317598#ENSG00000112715#ENST00000324450#Other#PDGF$#ENSP00000361125#ENSG00000112715#ENST00000372055#Other#PDGF, VEGF_C$#ENSP00000361134#ENSG00000112715#ENST00000372064#Other#PDGF$#ENSP00000361137#ENSG00000112715#ENST00000372067#Other#PDGF, VEGF_C$#ENSP00000361148#ENSG00000112715#ENST00000372077#Other#PDGF$#ENSP00000389864#ENSG00000112715#ENST00000413642#Other#PDGF, VEGF_C$#ENSP00000388663#ENSG00000112715#ENST00000417285#Other#PDGF, VEGF_C$#ENSP00000388465#ENSG00000112715#ENST00000425836#Other#PDGF, VEGF_C$#ENSP00000409911#ENSG00000112715#ENST00000457104#Other#PDGF$#ENSP00000421561#ENSG00000112715#ENST00000482630#Other#PDGF, VEGF_C$#ENSP00000430829#ENSG00000112715#ENST00000518689#Other#PDGF, VEGF_C$#ENSP00000430002#ENSG00000112715#ENST00000518824#Other#PDGF, VEGF_C$#ENSP00000428321#ENSG00000112715#ENST00000520948#Other#PDGF, VEGF_C$#ENSP00000429008#ENSG00000112715#ENST00000523125#Other#PDGF, VEGF_C$#ENSP00000430479#ENSG00000112715#ENST00000523873#Other#PDGF, VEGF_C$#ENSP00000429643#ENSG00000112715#ENST00000523950#Other#PDGF, VEGF_C$#ENSP00000478570#ENSG00000112715#ENST00000611736#Other#PDGF, VEGF_C$#ENSP00000478034#ENSG00000112715#ENST00000615393#Other#PDGF$#ENSP00000484284#ENSG00000112715#ENST00000617771#Other#PDGF$#ENSP00000483241#ENSG00000112715#ENST00000621747#Other#PDGF, VEGF_C$#ENSP00000230480#ENSG00000112715#ENST00000230480#Other#PDGF, VEGF_C	FALSE
2728	ENSG00000102243	VGLL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Likely transcriptional cofactor (PMID: 10518497)	None	51442	Transcription cofactor vestigial-like protein 1	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Laura Campitelli	Sam Lambert	No	$#ENSG00000102243#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000102243##Other#	FALSE
2729	ENSG00000170162	VGLL2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Co-activator that binds TEF family TFs (PMID: 14762206)	IPR011520	245806	vestigial like family member 2 [Source:HGNC Symbol;Acc:HGNC:20232]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14762206	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000170162#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000170162##Other#	FALSE
2730	ENSG00000206538	VGLL3	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 23380592) describes this protein as  a co-activator, and it doesnt seem to have a DBD (fig. 1)	None	389136	Transcription cofactor vestigial-like protein 3	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	$#ENSG00000206538#GO:0003705#RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$##ENSG00000206538##Other#	FALSE
2731	ENSG00000189030	VHLL	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Interacts with TFs as part of an E3 ubiquitin ligase complex (PMID: 12682018).  No evidence for DNA binding.	IPR022772	391104	von Hippel-Lindau tumor suppressor like [Source:HGNC Symbol;Acc:HGNC:30666]	None	not tested	not tested	None	None	No	No	TF Gene Candidate__Transactivation_PMIDS:12682018	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$##ENSG00000189030##Other#	FALSE
2732	ENSG00000163159	VPS72	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	VPS72 (YL1) is a histone chaperone. YL1 binding to the H2A.Z-H2B dimer is mutually exclusive from the dimer binding DNA (PMID: 26974126)	IPR008895;IPR013272	6944	vacuolar protein sorting 72 homolog [Source:HGNC Symbol;Acc:HGNC:11644]	None	not tested	not tested	None	None	x	No	Probably Not a TF - No evidence that it is a TF__Other_PMIDS:15647280	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Arttu Jolma	No	None	$#ENSP00000357887#ENSG00000163159#ENST00000368892#Other#YL1, YL1_C$#ENSP00000346464#ENSG00000163159#ENST00000354473#Other#YL1, YL1_C	FALSE
2733	ENSG00000109501	WFS1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR026208;IPR026209	7466	wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000109501#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:20160352	$#ENSP00000226760#ENSG00000109501#ENST00000226760#Other#$#ENSP00000423337#ENSG00000109501#ENST00000503569#Other#$#ENSP00000424103#ENSG00000109501#ENST00000506362#Other#	FALSE
2734	ENSG00000125084	WNT1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR005817;IPR009139;IPR018161	7471	Wnt family member 1 [Source:HGNC Symbol;Acc:HGNC:12774]	None	not tested	not tested	None	None	No	No	Not a TF - Evidence that it is not a TF___PMIDS:0	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Jussi Taipale	No	$#ENSG00000125084#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#ISS - GO_REF:0000024	$#ENSP00000293549#ENSG00000125084#ENST00000293549#Other#wnt$#ENSP00000481240#ENSG00000125084#ENST00000613114#Other#wnt	FALSE
2735	ENSG00000169884	WNT10B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a secreted signaling protein	None	7480	Protein Wnt-10b	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000169884#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000169884##Other#	FALSE
2736	ENSG00000105989	WNT2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR005817;IPR009140;IPR018161	7472	Wnt family member 2 [Source:HGNC Symbol;Acc:HGNC:12780]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	$#ENSG00000105989#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10557084	$#ENSP00000265441#ENSG00000105989#ENST00000265441#Other#wnt$#ENSP00000419466#ENSG00000105989#ENST00000491214#Other#wnt	FALSE
2737	ENSG00000154342	WNT3A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	None	89780	Protein Wnt-3a	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	$#ENSG00000154342#GO:0051091#positive regulation of sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000019	$##ENSG00000154342##Other#	FALSE
2738	ENSG00000114251	WNT5A	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 19847889) shows this protein as a part of a large EMSA shifting complex with RNA-Pol1, CHD1, and other DNA binding proteins. It does not, however, show evidence for it binding to DNA directly	IPR005817;IPR018161	7474	Wnt family member 5A [Source:HGNC Symbol;Acc:HGNC:12784]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Yimeng Yin	Arttu Jolma	No	$#ENSG00000114251#GO:0003700#sequence-specific DNA binding transcription factor activity#IMP - PMID:19847889$#ENSG00000114251#GO:0051092#positive regulation of NF-kappaB transcription factor activity#IDA - PMID:18287027	$#ENSP00000264634#ENSG00000114251#ENST00000264634#Other#wnt$#ENSP00000418184#ENSG00000114251#ENST00000482079#Other#wnt$#ENSP00000420104#ENSG00000114251#ENST00000497027#Other#wnt	FALSE
2739	ENSG00000075290	WNT8B	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	WNT family signaling molecule (PMID: 9536085)	IPR005817;IPR013301;IPR018161;	7479	Wnt family member 8B [Source:HGNC Symbol;Acc:HGNC:12789]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000340677#ENSG00000075290#ENST00000343737#Other#wnt	FALSE
2740	ENSG00000165392	WRN	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	ATP dependent DNA helicase. Binds DNA in the crystal structure (PDB: 3AAF)	None	7486	Werner syndrome RecQ like helicase	3AAF	not tested	not tested	None	None	No	No	No	No	New proteins added based on PDB entry	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2741	ENSG00000186153	WWOX	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Co-factor of AP-2 (PMID: 15548692)	IPR001202;IPR002198;IPR002347	51741	WW domain containing oxidoreductase [Source:HGNC Symbol;Acc:HGNC:12799]	None	not tested	not tested	None	None	No	No	TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:15548692	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	None	$##ENSG00000186153##Other#	FALSE
2742	ENSG00000198373	WWP2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR000008;IPR000569;IPR001202;IPR024928	11060	WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16804];NEDD4-like E3	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Pratyush Das	Sam Lambert	No	$#ENSG00000198373#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#ISS - PMID:15047715	$#ENSP00000352069#ENSG00000198373#ENST00000359154#Other#HECT, WW$#ENSP00000348283#ENSG00000198373#ENST00000356003#Other#HECT, WW$#ENSP00000456216#ENSG00000198373#ENST00000568684#Other#HECT, WW	FALSE
2743	ENSG00000018408	WWTR1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional co-activator that binds to TEADs (PMID: 19324877) and TBX5 (PMID: 16332960)	IPR001202	25937	WW domain containing transcription regulator 1 [Source:HGNC Symbol;Acc:HGNC:24042]	None	not tested	not tested	None	None	No	No	TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16332960	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	None	$##ENSG00000018408##Other#	FALSE
2744	ENSG00000143184	XCL1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a secreted chemokine	IPR001811;IPR008105	6375	X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:10645]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Arttu Jolma	No	$#ENSG00000143184#GO:0043433#negative regulation of sequence-specific DNA binding transcription factor activity#IDA - PMID:10887101	$#ENSP00000356792#ENSG00000143184#ENST00000367818#Other#IL8	FALSE
2745	ENSG00000136936	XPA	Unknown	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Functions in DNA repair (PMID: 19197159), but has a strong HT-SELEX-derived motif.	IPR000465;IPR009061;IPR022652;IPR022656;IPR022658;	7507	XPA, DNA damage recognition and repair factor [Source:HGNC Symbol;Acc:HGNC:12814]	None	Full	not tested	None	None	x	No	No	No	1a1, Direct HQ evidence	Matt Weirauch	Laura Campitelli	No	None	$#ENSP00000364270#ENSG00000136936#ENST00000375128#Other#XPA_C, XPA_N	FALSE
2746	ENSG00000163872	YEATS2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR005033;	55689	YEATS domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25489]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Pratyush Das	No	None	$#ENSP00000306983#ENSG00000163872#ENST00000305135#Other#YEATS$#ENSP00000406477#ENSG00000163872#ENST00000432781#Other#	FALSE
2747	ENSG00000127337	YEATS4	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Lacks a DBD and the study cited by GO annotation (PMID: 9302258) doesnt have experimental evidence for DNA-binding	IPR005033;	8089	YEATS domain containing 4 [Source:HGNC Symbol;Acc:HGNC:24859]	None	not tested	not tested	None	None	x	No	No	Yes	4a, two or more datasets predict it as a TF	Sam Lambert	Matt Weirauch	No	$#ENSG00000127337#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9302258	$#ENSP00000247843#ENSG00000127337#ENST00000247843#Other#SOGA, YEATS$#ENSP00000447199#ENSG00000127337#ENST00000548020#Other#SOGA$#ENSP00000448106#ENSG00000127337#ENST00000549685#Other#YEATS$#ENSP00000446985#ENSG00000127337#ENST00000552955#Other#YEATS	FALSE
2748	ENSG00000180667	YOD1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR003323;IPR007087;IPR029071;	55432	YOD1 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:25035]	None	Full	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000326813#ENSG00000180667#ENST00000315927#Other#OTU$#ENSP00000356051#ENSG00000180667#ENST00000367084#Other#OTU	FALSE
2749	ENSG00000188707	ZBED6CL	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	No DBDs on UniProt or Ensembl	IPR032675	113763	ZBED6 C-terminal like [Source:HGNC Symbol;Acc:HGNC:21720]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Laura Campitelli	No	$#ENSG00000188707#GO:0003700#sequence-specific DNA binding transcription factor activity#IBA - GO_REF:0000033	$#ENSP00000343242#ENSG00000188707#ENST00000343855#Other#	FALSE
2750	ENSG00000124256	ZBP1	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	ZBP1 is structurally-specific for Z-DNA, but does not have any sequence specificity (PDB: 1J75; PMID: 11524677)	IPR000607;IPR025735	81030	Z-DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:16176]	1J75	Full	not tested	None	None	x	No	No	No	1a1, Direct HQ evidence	Tim Hughes	Sam Lambert	No	None	$#ENSP00000360215#ENSG00000124256#ENST00000371173#Other#z-alpha$#ENSP00000379167#ENSG00000124256#ENST00000395822#Other#z-alpha$#ENSP00000404620#ENSG00000124256#ENST00000453793#Other#$#ENSP00000440552#ENSG00000124256#ENST00000541799#Other#RHIM, z-alpha	FALSE
2751	ENSG00000134744	ZCCHC11	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Likely a ssDNA or RNA binding protein based on domain composition	IPR001878;IPR002058;IPR002934;	23318	zinc finger CCHC-type containing 11 [Source:HGNC Symbol;Acc:HGNC:28981]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000257177#ENSG00000134744#ENST00000257177#Other#NTP_transf_2, PAP_assoc, zf-CCHC, zf-CCHC_2, zf-CC$#ENSP00000348063#ENSG00000134744#ENST00000355809#Other#$#ENSP00000435256#ENSG00000134744#ENST00000484723#Other#NTP_transf_2, PAP_assoc, zf-CCHC$#ENSP00000434367#ENSG00000134744#ENST00000470626#Other#$#ENSP00000434674#ENSG00000134744#ENST00000471623#Other#$#ENSP00000437091#ENSG00000134744#ENST00000494469#Other#$#ENSP00000432475#ENSG00000134744#ENST00000528457#Other#$#ENSP00000435700#ENSG00000134744#ENST00000531722#Other#PAP_assoc, zf-CCHC, zf-CCHC_2, zf-CCHC_4	FALSE
2752	ENSG00000083223	ZCCHC6	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	(PMID: 23709223) shows that it binds single-stranded nucleid acids	IPR001878;IPR002058;IPR003604;	79670	zinc finger CCHC-type containing 6 [Source:HGNC Symbol;Acc:HGNC:25817]	None	not tested	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Pratyush Das	No	None	$#ENSP00000365127#ENSG00000083223#ENST00000375960#Other#PAP_assoc, TUTF7_u4, tRNA_NucTransf2, zf-CCHC, zf-$#ENSP00000277141#ENSG00000083223#ENST00000277141#Other#NTP_transf_2, PAP_assoc, TUTF7_u4, zf-CCHC, zf-CCH$#ENSP00000365115#ENSG00000083223#ENST00000375948#Other#$#ENSP00000365124#ENSG00000083223#ENST00000375957#Other#PAP_assoc, TSNR_N, TUTF7_u4, zf-CCHC, zf-CCHC_2, z	FALSE
2753	ENSG00000188818	ZDHHC11	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None	IPR001594;	79844	zinc finger DHHC-type containing 11 [Source:HGNC Symbol;Acc:HGNC:19158]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Pratyush Das	Laura Campitelli	No	None	$#ENSP00000283441#ENSG00000188818#ENST00000283441#Other#zf-DHHC$#ENSP00000427067#ENSG00000188818#ENST00000511539#Other#$#ENSP00000426873#ENSG00000188818#ENST00000511193#Other#zf-DHHC$#ENSP00000397719#ENSG00000188818#ENST00000424784#Other#	FALSE
2754	ENSG00000163958	ZDHHC19	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ER transmembrane protein	IPR001594;	131540	zinc finger DHHC-type containing 19 [Source:HGNC Symbol;Acc:HGNC:20713]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Laura Campitelli	No	None	$#ENSP00000296326#ENSG00000163958#ENST00000296326#Other#zf-DHHC	FALSE
2755	ENSG00000146007	ZMAT2	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Possibly an RBP based on presence of a U1 ZF domain	IPR003604;IPR022755	153527	zinc finger matrin-type 2 [Source:HGNC Symbol;Acc:HGNC:26433]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	No	None	$#ENSP00000274712#ENSG00000146007#ENST00000274712#Other#Cgr1, DUF1777, zf-C2H2_jaz, zf-U1, zf-met$#ENSP00000473397#ENSG00000146007#ENST00000519913#Other#zf-C2H2_jaz, zf-U1, zf-met	FALSE
2756	ENSG00000123870	ZNF137P	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Pseudogene	Pseudogene	None	Has no Entrez identifier	Putative zinc finger protein 137	None	DBD	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Sam Lambert	Matt Weirauch	Yes	$#ENSG00000123870#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:7557990	$##ENSG00000123870##Other#	FALSE
2757	ENSG00000147394	ZNF185	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Protein has a LIM-subtype ZF.  This type of ZF is not likely to bind DNA (PMID: 17696879)	None	7739	zinc finger protein 185	None	not tested	not tested	None	None	No	No	No	No	New proteins added after initial stage	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2758	ENSG00000075292	ZNF638	Unknown	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	None	Binds C-rich dsDNA with low affinity (PMID: 8647861).	IPR000504;IPR000690;IPR003604;IPR007087;IPR015880;IPR022755	27332	zinc finger protein 638 [Source:HGNC Symbol;Acc:HGNC:17894]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Pratyush Das	No	None	$#ENSP00000264447#ENSG00000075292#ENST00000264447#Other#AKAP95, zf-C2H2_jaz$#ENSP00000386433#ENSG00000075292#ENST00000409544#Other#AKAP95, zf-C2H2_jaz$#ENSP00000485608#ENSG00000075292#ENST00000410075#Other#$#ENSP00000388164#ENSG00000075292#ENST00000437658#Other#$#ENSP00000396909#ENSG00000075292#ENST00000417778#Other#$#ENSP00000409647#ENSG00000075292#ENST00000454122#Other#$#ENSP00000485192#ENSG00000075292#ENST00000461991#Other#zf-C2H2_jaz$#ENSP00000485266#ENSG00000075292#ENST00000464375#Other#$#ENSP00000485494#ENSG00000075292#ENST00000466330#Other#$#ENSP00000485618#ENSG00000075292#ENST00000494621#Other#	FALSE
2759	ENSG00000197302	ZNF720	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a KRAB domain (associated with many C2H2 ZFs), but no annotated C2H2 on PDB or UniProt	IPR001909;IPR026245	107983990	zinc finger protein 720 [Source:HGNC Symbol;Acc:HGNC:26987]	None	Full	not tested	None	None	c	No	No	No	5a, one of the source datasets predicts is as a TF	Sam Lambert	Yimeng Yin	No	None	$#ENSP00000319222#ENSG00000197302#ENST00000316491#Other#KRAB$#ENSP00000435171#ENSG00000197302#ENST00000530881#Other#KRAB$#ENSP00000437310#ENSG00000197302#ENST00000529515#Other#KRAB$#ENSP00000431546#ENSG00000197302#ENST00000534369#Other#FRG2$#ENSP00000441893#ENSG00000197302#ENST00000539915#Other#	FALSE
2760	ENSG00000172687	ZNF738	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Contains a KRAB domain (associated with many C2H2 ZFs), but no annotated C2H2 on PDB or UniProt	IPR001909;	124411	zinc finger protein 738 [Source:HGNC Symbol;Acc:HGNC:32469]	None	not tested	not tested	None	None	x	No	No	No	5a, one of the source datasets predicts is as a TF	Jussi Taipale	Sam Lambert	No	None	$#ENSP00000311957#ENSG00000172687#ENST00000311015#Other#KRAB$#ENSP00000370252#ENSG00000172687#ENST00000380870#Other#KRAB$#ENSP00000470939#ENSG00000172687#ENST00000594245#Other#$#ENSP00000471336#ENSG00000172687#ENST00000597810#Other#KRAB	FALSE
2761	ENSG00000106479	ZNF862	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	Contains a KRAB domain (associated with many C2H2 ZFs), but no annotated C2H2 on PDB or UniProt	None	643641	zinc finger protein 862	None	not tested	not tested	None	None	No	No	No	No	New proteins added after initial stage	Arttu Jolma	Sam Lambert	No	None	None	FALSE
2762	ENSG00000124201	ZNFX1	Unknown	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Probably an RBP (PMID: 22658674; PMID: 22681889)	IPR000967;IPR016024;IPR027417;	57169	zinc finger NFX1-type containing 1 [Source:HGNC Symbol;Acc:HGNC:29271]	None	DBD	not tested	None	None	a	No	No	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Matt Weirauch	Yes	$#ENSG00000124201#GO:0003700#sequence-specific DNA binding transcription factor activity#IEA - GO_REF:0000002	$#ENSP00000360819#ENSG00000124201#ENST00000371754#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, P$#ENSP00000379412#ENSG00000124201#ENST00000396105#Other#AAA_11, AAA_12, AAA_19, AAA_22, AAA_30, DUF2075, R$#ENSP00000360809#ENSG00000124201#ENST00000371744#Other#AAA_11, AAA_19, AAA_30, DUF2075, PhoH, ResIII$#ENSP00000413800#ENSG00000124201#ENST00000455070#Other#AAA_11, AAA_19, AAA_30, DUF2075, PhoH, ResIII, Uvr	FALSE
2763	ENSG00000132485	ZRANB2	Unknown	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Its the wrong kind of zinc finger to bind DNA. Likely binds RNA.  PMID cited by GO (PMID: 9931435) does not have evidence of sequence-specific DNA binding.	IPR001876;IPR017337	9406	zinc finger RANBP2-type containing 2 [Source:HGNC Symbol;Acc:HGNC:13058]	None	not tested	not tested	None	None	No	No	No	Yes	5a, one of the source datasets predicts is as a TF	Tim Hughes	Matt Weirauch	No	$#ENSG00000132485#GO:0003700#sequence-specific DNA binding transcription factor activity#TAS - PMID:9931435	$#ENSP00000254821#ENSG00000132485#ENST00000254821#Other#zf-RanBP$#ENSP00000359958#ENSG00000132485#ENST00000370920#Other#zf-RanBP$#ENSP00000482026#ENSG00000132485#ENST00000611683#Other#zf-RanBP	FALSE
2764	ENSG00000107372	ZFAND5	ZZ-type ZF	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	An RNA-binding protein that recognises 3UTR located AU-rich elements in mRNA molecules to stabilize them (PMID: 22665488)	IPR000058;IPR002653	7763	zinc finger AN1-type containing 5 [Source:HGNC Symbol;Acc:HGNC:13008]	None	not tested	not tested	None	None	No	No	Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0	No	5a, one of the source datasets predicts is as a TF	Arttu Jolma	Yimeng Yin	No	None	$##ENSG00000107372##Other#	FALSE