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    <title>Synaptic targets of photoreceptors specialized to detect color and skylight polarization
      in Drosophila</title>
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        <h1 itemscope="" itemtype="http://schema.stenci.la/Array" itemprop="headline"
          content="Synaptic targets of photoreceptors specialized to detect color and skylight polarization in  Drosophila">
          Synaptic targets of photoreceptors specialized to detect color and skylight polarization
          in <em itemscope="" itemtype="http://schema.stenci.la/Emphasis">Drosophila</em></h1>
        <meta itemprop="image"
          content="https://via.placeholder.com/1200x714/dbdbdb/4a4a4a.png?text=">
        <ol data-itemprop="authors">
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Emil Kind"><span data-itemprop="givenNames"><span
                itemprop="givenName">Emil</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Kind</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-1">1</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Kit D Longden"><span data-itemprop="givenNames"><span
                itemprop="givenName">Kit</span><span itemprop="givenName">D</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Longden</span></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Aljoscha Nern"><span data-itemprop="givenNames"><span
                itemprop="givenName">Aljoscha</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Nern</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Arthur Zhao"><span data-itemprop="givenNames"><span
                itemprop="givenName">Arthur</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Zhao</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Gizem Sancer"><span data-itemprop="givenNames"><span
                itemprop="givenName">Gizem</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Sancer</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-1">1</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Miriam A Flynn"><span data-itemprop="givenNames"><span
                itemprop="givenName">Miriam</span><span itemprop="givenName">A</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Flynn</span></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Connor W Laughland"><span
              data-itemprop="givenNames"><span itemprop="givenName">Connor</span><span
                itemprop="givenName">W</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Laughland</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Bruck Gezahegn"><span data-itemprop="givenNames"><span
                itemprop="givenName">Bruck</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Gezahegn</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Henrique DF Ludwig"><span
              data-itemprop="givenNames"><span itemprop="givenName">Henrique</span><span
                itemprop="givenName">DF</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Ludwig</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Alex G Thomson"><span data-itemprop="givenNames"><span
                itemprop="givenName">Alex</span><span itemprop="givenName">G</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Thomson</span></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Tessa Obrusnik"><span data-itemprop="givenNames"><span
                itemprop="givenName">Tessa</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Obrusnik</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-1">1</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Paula G Alarcón"><span data-itemprop="givenNames"><span
                itemprop="givenName">Paula</span><span itemprop="givenName">G</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Alarcón</span></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-1">1</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Heather Dionne"><span data-itemprop="givenNames"><span
                itemprop="givenName">Heather</span></span><span data-itemprop="familyNames"><span
                itemprop="familyName">Dionne</span></span><span data-itemprop="affiliations"><a
                itemprop="affiliation" href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Davi D Bock"><span data-itemprop="givenNames"><span
                itemprop="givenName">Davi</span><span itemprop="givenName">D</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Bock</span></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Gerald M Rubin"><span data-itemprop="givenNames"><span
                itemprop="givenName">Gerald</span><span itemprop="givenName">M</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Rubin</span></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Michael B Reiser"><span data-itemprop="givenNames"><span
                itemprop="givenName">Michael</span><span itemprop="givenName">B</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Reiser</span></span><span
              data-itemprop="emails"><a itemprop="email"
                href="mailto:reiserm@janelia.hhmi.org">reiserm@janelia.hhmi.org</a></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-2">2</a></span>
          </li>
          <li itemscope="" itemtype="http://schema.org/Person" itemprop="author">
            <meta itemprop="name" content="Mathias F Wernet"><span data-itemprop="givenNames"><span
                itemprop="givenName">Mathias</span><span itemprop="givenName">F</span></span><span
              data-itemprop="familyNames"><span itemprop="familyName">Wernet</span></span><span
              data-itemprop="emails"><a itemprop="email"
                href="mailto:mathias.wernet@fu-berlin.de">mathias.wernet@fu-berlin.de</a></span><span
              data-itemprop="affiliations"><a itemprop="affiliation"
                href="#author-organization-1">1</a></span>
          </li>
        </ol>
        <ol data-itemprop="affiliations">
          <li itemscope="" itemtype="http://schema.org/Organization" itemid="#author-organization-1"
            id="author-organization-1"><span itemprop="name">Instititut für Biologie – Abteilung
              Neurobiologie, Fachbereich Biologie, Chemie &amp; Pharmazie, Freie Universität
              Berlin</span><address itemscope="" itemtype="http://schema.org/PostalAddress"
              itemprop="address"><span itemprop="addressLocality">Berlin</span><span
                itemprop="addressCountry">Germany</span></address></li>
          <li itemscope="" itemtype="http://schema.org/Organization" itemid="#author-organization-2"
            id="author-organization-2"><span itemprop="name">Janelia Research Campus, Howard Hughes
              Medical Institute</span><address itemscope=""
              itemtype="http://schema.org/PostalAddress" itemprop="address"><span
                itemprop="addressLocality">Ashburn</span><span itemprop="addressCountry">United
                States</span></address></li>
        </ol><span itemscope="" itemtype="http://schema.org/Organization" itemprop="publisher">
          <meta itemprop="name" content="Unknown"><span itemscope=""
            itemtype="http://schema.org/ImageObject" itemprop="logo">
            <meta itemprop="url"
              content="https://via.placeholder.com/600x60/dbdbdb/4a4a4a.png?text=Unknown">
          </span>
        </span><time itemprop="datePublished" datetime="2021-12-16">2021-12-16</time>
        <ul data-itemprop="genre">
          <li itemprop="genre">Research Article</li>
        </ul>
        <ul data-itemprop="about">
          <li itemscope="" itemtype="http://schema.org/DefinedTerm" itemprop="about"><span
              itemprop="name">Neuroscience</span></li>
        </ul>
        <ul data-itemprop="keywords">
          <li itemprop="keywords">connectomics</li>
          <li itemprop="keywords">color vision</li>
          <li itemprop="keywords">skylight polarization</li>
          <li itemprop="keywords">D. melanogaster</li>
        </ul>
        <ul data-itemprop="identifiers">
          <li itemscope="" itemtype="http://schema.org/PropertyValue" itemprop="identifier">
            <meta itemprop="propertyID"
              content="https://registry.identifiers.org/registry/publisher-id"><span
              itemprop="name">publisher-id</span><span itemprop="value"
              data-itemtype="http://schema.org/Number">71858</span>
          </li>
          <li itemscope="" itemtype="http://schema.org/PropertyValue" itemprop="identifier">
            <meta itemprop="propertyID" content="https://registry.identifiers.org/registry/doi">
            <span itemprop="name">doi</span><span itemprop="value">10.7554/eLife.71858</span>
          </li>
          <li itemscope="" itemtype="http://schema.org/PropertyValue" itemprop="identifier">
            <meta itemprop="propertyID"
              content="https://registry.identifiers.org/registry/elocation-id"><span
              itemprop="name">elocation-id</span><span itemprop="value">e71858</span>
          </li>
        </ul>
        <section data-itemprop="description">
          <h2 data-itemtype="http://schema.stenci.la/Heading">Abstract</h2>
          <meta itemprop="description"
            content="Color and polarization provide complementary information about the world and are detected by specialized photoreceptors. However, the downstream neural circuits that process these distinct modalities are incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed the synaptic targets of the photoreceptors specialized to detect color and skylight polarization in  Drosophila , and we have used light microscopy to confirm many of our findings. We identified known and novel downstream targets that are selective for different wavelengths or polarized light, and followed their projections to other areas in the optic lobes and the central brain. Our results revealed many synapses along the photoreceptor axons between brain regions, new pathways in the optic lobes, and spatially segregated projections to central brain regions. Strikingly, photoreceptors in the polarization-sensitive dorsal rim area target fewer cell types, and lack strong connections to the lobula, a neuropil involved in color processing. Our reconstruction identifies shared wiring and modality-specific specializations for color and polarization vision, and provides a comprehensive view of the first steps of the pathways processing color and polarized light inputs.">
          <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Color and polarization
            provide complementary information about the world and are detected by specialized
            photoreceptors. However, the downstream neural circuits that process these distinct
            modalities are incompletely understood in any animal. Using electron microscopy, we have
            systematically reconstructed the synaptic targets of the photoreceptors specialized to
            detect color and skylight polarization in <em itemscope=""
              itemtype="http://schema.stenci.la/Emphasis">Drosophila</em>, and we have used light
            microscopy to confirm many of our findings. We identified known and novel downstream
            targets that are selective for different wavelengths or polarized light, and followed
            their projections to other areas in the optic lobes and the central brain. Our results
            revealed many synapses along the photoreceptor axons between brain regions, new pathways
            in the optic lobes, and spatially segregated projections to central brain regions.
            Strikingly, photoreceptors in the polarization-sensitive dorsal rim area target fewer
            cell types, and lack strong connections to the lobula, a neuropil involved in color
            processing. Our reconstruction identifies shared wiring and modality-specific
            specializations for color and polarization vision, and provides a comprehensive view of
            the first steps of the pathways processing color and polarized light inputs.</p>
        </section>
        <h2 itemscope="" itemtype="http://schema.stenci.la/Heading" id="introduction">Introduction
        </h2>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Both the wavelength and the
          polarization angle of light contain valuable information that can be exploited by many
          visual animals. For instance, color gradients across the sky can serve as navigational
          cues, and skylight’s characteristic pattern of linear polarization can also inform
          navigation by indicating the orientation relative to the sun (<cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib25"><span>25</span><span>Heinze</span><span>2017</span></a></cite>; <a
            href="#fig1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1A</a>). The
          spectral content of light is detected by groups of photoreceptor cells containing
          rhodopsin molecules with different sensitivities, often organized in stochastic retinal
          mosaics <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib77"><span>77</span><span>Rister and
                Desplan</span><span>2011</span></a></cite>, and specialized, polarization-sensitive
          photoreceptors have been characterized in many species, both vertebrates and invertebrates
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib63"><span>63</span><span>Nilsson and
                Warrant</span><span>1999</span></a></cite>. These two visual modalities, color and
          polarization vision, require the processing of signals over a wide range of spatial and
          temporal scales, and many questions remain about how the signals from functionally
          specialized photoreceptors are integrated in downstream neurons. Are color and
          polarization signals mixed at an early stage, or are they processed by different,
          modality-specific cell types? Do separate pathways exist that selectively process and
          convey information from photoreceptor types in the retinal mosaic to targets in the
          central brain? The full scope of the early synaptic stages of color and polarization
          circuitry is unknown in any animal, and the analysis of electron microscopy (EM)
          connectomes is ideally suited to exhaustively answer these questions, especially when
          corroborated with genetic labeling of cell types and circuit elements imaged with light
          microscopy. We make significant progress on the questions by mapping the neuronal
          connections of specialized, identified photoreceptors within the <em itemscope=""
            itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> full adult fly brain data
          set <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib117"><span>117</span><span>Zheng et al.</span><span>2018</span></a></cite>
          and validate many of these results by using the powerful genetic tools available in <em
            itemscope="" itemtype="http://schema.stenci.la/Emphasis">Drosophila</em>.</p>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig1" title="Figure 1.">
          <label data-itemprop="label">Figure 1.</label><img src="index.html.media/fig1.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="systematic-reconstruction-of-all-synaptic-targets-of-inner-photoreceptor-subtypes">
              Systematic reconstruction of all synaptic targets of inner photoreceptor subtypes.
            </h3>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Simplified schematic
              summarizing some of the most salient visual stimuli of a fly (center): celestial cues
              (sun), color gradients (distribution of green versus UV wavelengths) and skylight
              polarization (as defined by degree of polarization and angle of polarization) can be
              used for navigation, as well as more or less colorful landmarks (tree). (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>) Schematic
              representation of the fly visual system. Left: In the retina, inner photoreceptor R7
              (distal) and R8 (proximal) rhodopsin expression differs across three functionally
              specialized subtypes pale (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">p</strong>), yellow (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">y</strong>), and DRA (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">d</strong>). Rh3 and Rh4 opsins are both
              UV-sensitive, whereas Rh5 and Rh6 are more sensitive to blue and green wavelengths,
              respectively. R1-6 express Rh1 and are broadly sensitive to green and UV wavelengths.
              Only in the DRA, both R7 and R8 axons terminate in the same layer of the medulla
              neuropil (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">M6</strong>),
              which is the target layer of R7 cells outside the DRA, and non-DRA R8 cells terminate
              in layer M3. Right: Overview of the main four optic lobe neuropils. Only the lamina
              and medulla receive direct photoreceptor input. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Distribution of medulla
              columns downstream of either p (light blue), y (yellow), and DRA (red) photoreceptors
              reconstructed from the <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                  href="#bib117"><span>117</span><span>Zheng et
                    al.</span><span>2018</span></a></cite> data set. Pale columns were assigned via
              presence of aMe12 long vertical projections (see below). Seven seed columns used for
              systematic reconstruction are highlighted with black circles. The colored axes
              indicate the orientation of the displayed view: green for lateral, magenta for dorsal,
              and blue for posterior axes. Scale bar: 20 μm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) Double labeling of aMe12
              vertical processes and yellow R8 cells. See Materials and methods and <a href="#supp4"
                itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary file 4</a> for
              fly genotypes and other details of this and other light microscopy panels. Left (Di)
              Confocal image showing the array of medulla columns with labeling of aMe12 neurons
              (purple) and yellow R8 axons (green). Note that the two patterns appear near-mutually
              exclusive. Right (Dii) Side view of aMe12 vertical projections and pale R7 axons
              (green). (Di–ii) Scale bars: 20 μm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">E</strong>) Left (Ei) Skeleton of the
              optic lobe part of a fully reconstructed aMe12 neuron (gray), with processes leaving
              the medulla through the accessory medulla (pink). (Eii) Across the four central seed
              columns (darker shading), synaptic input from R7 (purple dots) and R8 photoreceptors
              (green dots) to aMe12 is specific to the designated pale columns. (Eiii) Left:
              Sideview depicting the distribution of R7 and R8 inputs into aMe12 across medulla
              layers (color code of pale and yellow columns as before). Right: Same distribution
              plotted as synapses/μm, for both pale and yellow columns (color code as before).
              (Ei–iii) Scale bars: 10 μm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">F</strong>) Reconstructed pale R7 and R8,
              yellow R7 and R8, and R7-DRA and R8-DRA terminals with R7 presynapses in purple and R8
              presynapses in green. Note the termination of R8-DRA in the R7 target layer M6
              (arrow). Scale bars: 10 μm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">G</strong>) Illustrations of examples of
              cell types from reconstructed neuron classes, including lamina monopolar (L3), distal
              medulla (Dm9), medulla intrinsic (Mi15), transmedulla (Tm20), medulla tangential
              intrinsic (Mti), visual projection neurons targeting the central brain (e.g. aMe12),
              and medulla-to-tubercle (MeTu) cells projecting to the anterior optic tubercle (AOTU).
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">H</strong>) For the
              synapses from seed column inner photoreceptors to cells with ≥3 synapses, we
              identified the cell type or cell class of 99.5% (3803/3821 synapses). Overview of the
              relative strength of these connections with different neuron classes (color code as
              before), including with the unidentified cells (<a href="#table2" itemscope=""
                itemtype="http://schema.stenci.la/Link">Table 2</a>, <a href="#table3" itemscope=""
                itemtype="http://schema.stenci.la/Link">Table 3</a>, <a href="#table4" itemscope=""
                itemtype="http://schema.stenci.la/Link">Table 4</a>, <a href="#table5" itemscope=""
                itemtype="http://schema.stenci.la/Link">Table 5</a>), across pale, yellow, and DRA
              columns (pre- and postsynaptic). Area of circles corresponds to the number of synapses
              per R7 and R8 cell.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig1s1"
          title="Figure 1—figure supplement 1."><label data-itemprop="label">Figure 1—figure
            supplement 1.</label><img src="index.html.media/fig1-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="example-electron-microscopy-em-images">Example electron microscopy (EM) images.
            </h3>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Example EM images of
              photoreceptor synapses in medulla layer 6. Top: R7 synapse (T-bar labeled) with
              postsynaptic Dm2, Dm8, Dm9, and Tm5b cells. Bottom: R8-DRA synapse, with postsynaptic
              Dm9 and Dm-DRA2 cells. R8 synapses in layer 6 were diagnostic of DRA columns (see
              Materials and methods). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Images of synapses outside the
              medulla in the central (top) and DRA (bottom) seed columns. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Two examples of photoreceptor
              synapses with glia, with the arrows indicating the postsynaptic density in the glial
              cell. Scale bars: 500 μm.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig1s2"
          title="Figure 1—figure supplement 2."><label data-itemprop="label">Figure 1—figure
            supplement 2.</label><img src="index.html.media/fig1-figsupp2.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="comparison-with-medulla-7-column-connectome">Comparison with medulla-7-column
              connectome.</h3>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Left: Comparison of total
              numbers of synaptic inputs to R7 (purple, circles) and R8 (green, squares) in our data
              set (filled symbols) and a medulla-7-column connectome (open symbols), with mean
              values are indicated by black symbols. These plotting conventions are used throughout
              the figure. We used the six columns identified as pale and yellow in the
              medulla-7-column connectome <cite itemscope=""
                itemtype="http://schema.stenci.la/Cite"><a
                  href="#bib96"><span>96</span><span>Takemura et
                    al.</span><span>2015</span></a></cite> by <cite itemscope=""
                itemtype="http://schema.stenci.la/Cite"><a href="#bib56"><span>56</span><span>Menon
                    et al.</span><span>2019</span></a></cite>, made available in <cite itemscope=""
                itemtype="http://schema.stenci.la/Cite"><a href="#bib7"><span>7</span><span>Clements
                    et al.</span><span>2020</span></a></cite>, see Materials and methods. Right: The
              R7-8 photoreceptors and Dm9 inputs dominate the synaptic input to R7 (purple, circles)
              and to R8 (green, squares); the increased number of synapses outside medulla (see
              panel G) likely accounts for the higher number of inputs to our R7-8 cells. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>) Comparison of the
              total number of output synapses from R7 and R8. We reconstructed more output synapses,
              per cell, than in medulla-7-column connectome. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Comparison of total numbers of
              R7-8 output synapses disaggregated by cell classes. To enable like-for-like
              comparisons, we used only cell classes and cell types annotated in both data sets,
              with the cell types shown in D. To quantify the completeness of cell type
              identification, we counted all other identified cell types found each data set in the
              ‘Other’ category. Our reconstruction found a large increase in R7 synapses to
              multicolumnar Dm cells, and increases in R8 synapses to multicolumnar cell classes,
              such as Tm cells and cells like aMe12 in the ‘Other’ class. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) Comparison of total numbers of
              R7 (top) and R8 (bottom) output synapses disaggregated by cell type, with cell types
              grouped from left to right by their cell class categories in C. For R7, there were
              increases in synapses to R8 and L3, which receive synapses outside the medulla, and
              Dm8 cells, which are multicolumnar. For R8, there were increases in synapses to R7 and
              Mi15, which receive synapses outside the medulla, and multicolumnar Tm5c and ‘Other’
              cell types, and also Tm20 cells, which may be surprising because this cell type is
              columnar. (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">E</strong>)
              Comparison of R7-8 synapses to (medulla-7-column connectome) Dm7 and (current study)
              MeTu cells. These two cell types were the only cell type discrepancies between the
              data sets: Dm7 cells were major targets of R7 in the medulla-7-column connectome, but
              not in ours, while MeTu cells were major targets in our data but not in the
              medulla-7-column connectome. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">F</strong>) Example Tm cell (brown, Tm
              #11770) in the medulla-7-column connectome whose dendritic morphology matched MeTu
              cell. Two R7 cells (green, left, and purple, right) are also shown, along with R7
              synapses (green circles) and Mi15 synapses (purple). We propose that some MeTu cells
              are included in the medulla-7-column connectome but are currently annotated as
              unidentified Tm or Dm7 cells. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">G</strong>) Percentages of synapses
              outside the medulla for R7 (left) and R8 (right) with cell types in the central (top)
              and DRA (bottom) seed columns. L3 in particular is almost exclusively innervated
              outside the medulla. Tables of synapses outside the medulla are listed for each cell
              type in <a href="#supp3" itemscope=""
                itemtype="http://schema.stenci.la/Link">Supplementary file 3</a>.</p>
          </figcaption>
        </figure>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">While studies in many insects
          have contributed to the understanding of polarized light and color vision <span
            itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib29"><span>29</span><span>Homberg</span><span>2015</span></a></cite><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib9"><span>9</span><span>Dacke and El
                  Jundi</span><span>2018</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib25"><span>25</span><span>Heinze</span><span>2017</span></a></cite><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib27"><span>27</span><span>Ibarra et
                  al.</span><span>2014</span></a></cite></span>, the visual system of <em
            itemscope="" itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> offers many
          advantages for the exploration of neural circuits <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib113"><span>113</span><span>Wernet
                et al.</span><span>2014</span></a></cite>. Anatomical studies are facilitated by the
          stereotyped, repetitive structure of the optic lobes, with many cell types, the so-called
          columnar neurons, found in repeated circuit units, called visual columns, that are
          retinotopically arranged and each correspond to one of the ~800 unit eyes (ommatidia) of
          the compound eye. Over 100 optic lobe cell types have been described in classical Golgi
          work <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib17"><span>17</span><span>Fischbach and
                Dittrich</span><span>1989</span></a></cite>, by more recent studies combining
          genetic labeling with light microscopy <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib58"><span>58</span><span>Morante
                  and Desplan</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib65"><span>65</span><span>Otsuna
                  and Ito</span><span>2006</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib115"><span>115</span><span>Wu et
                  al.</span><span>2016</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib60"><span>60</span><span>Nern et
                  al.</span><span>2015</span></a></cite></span> and, for some cell types, through EM
          reconstructions that have revealed not only cell morphologies but also detailed synaptic
          connectivity <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib94"><span>94</span><span>Takemura et
                  al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib95"><span>95</span><span>Takemura
                  et al.</span><span>2013</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                  et al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib52"><span>52</span><span>Meinertzhagen and
                  O’Neil</span><span>1991</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib78"><span>78</span><span>Rivera-Alba et
                  al.</span><span>2011</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib89"><span>89</span><span>Shinomiya et
                  al.</span><span>2014</span></a></cite></span>. Furthermore, genetic tools <span
            itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib33"><span>33</span><span>Jenett
                  et al.</span><span>2012</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib72"><span>72</span><span>Pfeiffer
                  et al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib40"><span>40</span><span>Kvon et
                  al.</span><span>2014</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib11"><span>11</span><span>Dionne
                  et al.</span><span>2018</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib99"><span>99</span><span>Tirian
                  and Dickson</span><span>2017</span></a></cite></span>, and, most recently, gene
          expression data <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib10"><span>10</span><span>Davis et
                  al.</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib38"><span>38</span><span>Konstantinides et
                  al.</span><span>2018</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib67"><span>67</span><span>Özel et
                  al.</span><span>2021</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib39"><span>39</span><span>Kurmangaliyev et
                  al.</span><span>2020</span></a></cite></span> are available for many optic lobe
          cell types. An enabling feature of this emerging body of work is that in nearly all cases,
          distinct cell types can be reliably identified across data sets, such that new studies
          often directly enrich prior ones.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Each <em itemscope=""
            itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> ommatidium contains eight
          photoreceptors whose output is processed in a series of neuropils called the lamina,
          medulla, lobula, and lobula plate that together form the optic lobes of the fly <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib17"><span>17</span><span>Fischbach and
                Dittrich</span><span>1989</span></a></cite>. Outer photoreceptors R1-6 project to
          the lamina neuropil, and serve as the main input to the motion vision circuitry <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib50"><span>50</span><span>Mauss et al.</span><span>2017</span></a></cite>;
          inner photoreceptors R7 and R8 pass through the lamina without connections and project
          directly to the deeper medulla neuropil, which also receives lamina projections <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib17"><span>17</span><span>Fischbach and
                Dittrich</span><span>1989</span></a></cite>. The organization of the inner
          photoreceptors along the dorsal rim area (DRA) of the eye characteristically differs from
          that of the rest of the retina. In the non-DRA part of the retina, R7 and R8 differ in
          their axonal target layers, with R7 projecting to layer M6, and R8 to layer M3 <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib17"><span>17</span><span>Fischbach and
                Dittrich</span><span>1989</span></a></cite>. R7 and R8 also differ in their
          rhodopsin expression, being sensitive to short wavelength ultraviolet (UV, R7) and blue
          (R8), respectively, in so-called ‘pale’ ommatidia <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib6"><span>6</span><span>Chou et
                  al.</span><span>1996</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib71"><span>71</span><span>Papatsenko et
                  al.</span><span>1997</span></a></cite></span>, and to long wavelength UV (R7) and
          green (R8) in ‘yellow’ ommatidia (<cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib80"><span>80</span><span>Salcedo et
                al.</span><span>1999</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib30"><span>30</span><span>Huber et
                al.</span><span>1997</span></a></cite>; <a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1B</a>). Pale and yellow ommatidia are
          distributed randomly <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib15"><span>15</span><span>Feiler et
                  al.</span><span>1992</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib18"><span>18</span><span>Fortini
                  and Rubin</span><span>1990</span></a></cite></span>, at an uneven ratio that is
          conserved across insects <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib114"><span>114</span><span>Wernet
                  et al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib36"><span>36</span><span>Kind et
                  al.</span><span>2020</span></a></cite></span>. Meanwhile, DRA ommatidia are
          morphologically and molecularly specialized for detecting skylight polarization <span
            itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib111"><span>111</span><span>Wernet
                  et al.</span><span>2003</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib112"><span>112</span><span>Wernet
                  et al.</span><span>2012</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib103"><span>103</span><span>Wada</span><span>1974</span></a></cite></span>,
          that <em itemscope="" itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> can use
          to set a heading <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib48"><span>48</span><span>Mathejczyk and
                  Wernet</span><span>2019</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib49"><span>49</span><span>Mathejczyk and
                  Wernet</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib107"><span>107</span><span>Warren
                  et al.</span><span>2018</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib109"><span>109</span><span>Weir
                  and Dickinson</span><span>2012</span></a></cite></span>. In the DRA, the inner
          photoreceptors express the same UV rhodopsin (Rh3; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib19"><span>19</span><span>Fortini
                and Rubin</span><span>1991</span></a></cite>, <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib18"><span>18</span><span>Fortini
                and Rubin</span><span>1990</span></a></cite>) and detect perpendicular angles of
          polarized UV light <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib110"><span>110</span><span>Weir et al.</span><span>2016</span></a></cite>.
          In contrast to the rest of the medulla, R7-DRA and R8-DRA project to the same medulla
          layer (M6; <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib5"><span>5</span><span>Chin et al.</span><span>2014</span></a></cite>; <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib75"><span>75</span><span>Pollack and
                Hofbauer</span><span>1991</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib17"><span>17</span><span>Fischbach
                and Dittrich</span><span>1989</span></a></cite>), where their targets include
          polarization-specific cell types <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib81"><span>81</span><span>Sancer
                  et al.</span><span>2019</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib82"><span>82</span><span>Sancer
                  et al.</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib23"><span>23</span><span>Hardcastle et
                  al.</span><span>2021</span></a></cite></span>. Across insects, a ‘compass pathway’
          connects the DRA to the central brain via the anterior optic tubercle (AOTU; <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib29"><span>29</span><span>Homberg</span><span>2015</span></a></cite>; <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib23"><span>23</span><span>Hardcastle et
                al.</span><span>2021</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib73"><span>73</span><span>Pfeiffer
                and Kinoshita</span><span>2012</span></a></cite>). Anatomical and functional data
          from <em itemscope="" itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> suggests
          that the non-DRA medulla is also connected to the compass pathway <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib64"><span>64</span><span>Omoto et
                  al.</span><span>2017</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib23"><span>23</span><span>Hardcastle et
                  al.</span><span>2021</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib66"><span>66</span><span>Otsuna
                  et al.</span><span>2014</span></a></cite></span>, potentially forming parallel
          pathways for processing different celestial cues <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib98"><span>98</span><span>Timaeus
                  et al.</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib93"><span>93</span><span>Tai et
                  al.</span><span>2021</span></a></cite></span>.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">EM studies have already
          revealed some of the circuitry downstream of R7 and R8 <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib95"><span>95</span><span>Takemura
                  et al.</span><span>2013</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                  et al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite></span>. For example, axons of R7 and R8
          from the same ommatidium are reciprocally connected with inhibitory synapses <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib95"><span>95</span><span>Takemura et al.</span><span>2013</span></a></cite>,
          leading to color-opponent signals in their presynaptic terminals <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib86"><span>86</span><span>Schnaitmann et
                al.</span><span>2018</span></a></cite>. Interestingly, R7-DRA and R8-DRA also
          inhibit each other <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib110"><span>110</span><span>Weir et al.</span><span>2016</span></a></cite>.
          Other known R7 and R8 targets in the main medulla include local interneurons (e.g. Dm8;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib21"><span>21</span><span>Gao et al.</span><span>2008</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib68"><span>68</span><span>Pagni et
                al.</span><span>2021</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib56"><span>56</span><span>Menon et
                al.</span><span>2019</span></a></cite>) and projection neurons that provide
          connections to deeper optic lobe regions (e.g. Tm5 and Tm20 neurons; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib53"><span>53</span><span>Meinertzhagen et
                al.</span><span>2009</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                al.</span><span>2008</span></a></cite>). A previous light microscopy study <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite> identified a single cell type, Tm5a, that is
          specific for yellow medulla columns; this neuron has been used to identify pale and yellow
          columns in an EM volume <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib56"><span>56</span><span>Menon et
                  al.</span><span>2019</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                  et al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib34"><span>34</span><span>Karuppudurai et
                  al.</span><span>2014</span></a></cite></span>. Using genetic labeling techniques,
          four classes of TmY cells have also been reported as specific targets of pale versus
          yellow photoreceptors <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib32"><span>32</span><span>Jagadish et al.</span><span>2014</span></a></cite>,
          yet previous connectomic studies did not reveal similar cells. The currently most
          comprehensive EM study of the medulla reconstructed the connections between neurons in
          seven neighboring medulla columns <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                et al.</span><span>2015</span></a></cite>, revealing a detailed, yet incomplete,
          inventory of cell types connected to R7–8. This data set, now publicly available <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib7"><span>7</span><span>Clements et al.</span><span>2020</span></a></cite>,
          is remarkable for its dense reconstruction of columnar circuits, but could not be used to
          identify many multicolumnar neurons, that were cut-off at the edge of the data volume,
          leaving ~40% of R7–8 synapses onto unidentified cell types. In addition, no EM-based
          reconstructions of DRA neurons and their connections are currently available.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Here, we present a
          comprehensive reconstruction of all inner photoreceptor synaptic outputs and inputs, from
          pairs of pale and yellow columns and from three DRA columns in the <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib117"><span>117</span><span>Zheng et
                al.</span><span>2018</span></a></cite>, data set. These reconstructions were carried
          out within a full-brain volume, such that, for the first time, nearly all neurons
          connected to these photoreceptors were identified. We discovered, through light
          microscopy, a large visual projection neuron (VPN) with distinctive morphology, named
          accessory medulla cell type 12 (aMe12), that selectively innervates pale ommatidia across
          the medulla. We then reconstructed and subsequently used this cell to identify pale and
          yellow columns, from which we enumerated the connectivity of R7 and R8 with known and
          novel cell types within the optic lobes and projecting to the central brain, including
          more cells with pale-yellow specificity, and synapses on axons between neuropils. In the
          DRA, we show that cellular diversity is reduced, with local interneurons and projection
          neurons to the AOTU dominating, and connections to the lobula virtually missing. We
          identify circuit motifs shared between DRA and central columns, and describe
          modality-specific cell types, including cells with interhemispheric connections and
          projections to the central brain. Together, we identify the connected neurons that account
          for 96% of these inner photoreceptor synapses, a comprehensive set of the neurons that
          comprise the first step of the pathways through which color and polarization signals are
          transduced to the rest of the brain.</p>
        <h2 itemscope="" itemtype="http://schema.stenci.la/Heading" id="results">Results</h2>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="systematic-reconstruction-of-all-synaptic-targets-of-inner-photoreceptor-subtypes-1">
          Systematic reconstruction of all synaptic targets of inner photoreceptor subtypes</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">We reconstructed R7 and R8
          photoreceptor axons in the central region of the right optic lobe, as well as inner
          photoreceptors from 27 DRA columns from the <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib117"><span>117</span><span>Zheng et
                al.</span><span>2018</span></a></cite> data set (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1C</a>). From these, we selected seven
          ‘seed columns’ (four central, three DRA), for which all pre- and postsynaptic sites of the
          photoreceptor axons were identified and manually reconstructed, which is annotated and
          assembled across EM images (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1F</a>; Material and methods). There were
          422 skeletons, corresponding to individual cells, contacted by the seed column
          photoreceptors, and we focused our analysis on the 245 individual cells with &gt;2
          synapses to or from the photoreceptors. We reconstructed the morphology of these cells
          with a sufficient degree of completeness to ascribe a unique cell type to 92% (225/245) or
          to identify a cell class (Dm, Mi, Tm, or TmY cell class) for an additional 6.5% (16/245),
          so that 98% (241/245) of these cells were identified. We also traced and uniquely
          identified the cell type of all 30 cells that provided &gt;2 synaptic inputs to the
          photoreceptors. In total, we identified 4043 synaptic connections from the seed column R7
          and R8 photoreceptors, and 970 synaptic inputs to them, summarized in <a href="#fig1"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1H</a>.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">To distinguish between pale and
          yellow columns, we took advantage of our discovery of one specific cell type from the
          accessory medulla that widely arborized in the medulla with ascending branches that align
          with the photoreceptors (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1Ei–iii</a>). The cell type was selective
          for R8 input and showed a strong preference for innervating pale columns (<a href="#fig1"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1D and Eiii</a>). We
          identified three of these cells per hemisphere (hereinafter referred to as aMe12), which
          had heavily overlapping arbors, but only rarely shared ascending branches in the same
          columns (3/779 columns). Using the presence of aMe12 branches, we were able to assign as
          pale 38% (297/779) of the medulla columns, in good agreement with studies on the retinal
          mosaic of <em itemscope="" itemtype="http://schema.stenci.la/Emphasis">Drosophila</em>
          <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib15"><span>15</span><span>Feiler
                  et al.</span><span>1992</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib18"><span>18</span><span>Fortini
                  and Rubin</span><span>1990</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib2"><span>2</span><span>Bell et
                  al.</span><span>2007</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib28"><span>28</span><span>Hilbrant
                  et al.</span><span>2014</span></a></cite></span>. Since further analysis
          identified a total of 42 DRA columns (see below), we assigned the remaining columns as
          nominally yellow (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1C</a>). Our reconstructions also
          revealed another new pale-selective VPN, which we named ML-VPN1, and confirmed the
          previously reported yellow selectivity of Tm5a cells <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib56"><span>56</span><span>Menon et
                  al.</span><span>2019</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib34"><span>34</span><span>Karuppudurai et
                  al.</span><span>2014</span></a></cite></span>, findings that further supported the
          designations of pale and yellow seed columns (see below).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">After mapping the pale and
          yellow columns, we selected four adjacent central seed columns, two nominally pale and two
          nominally yellow (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1C</a>). Across the four central seed
          columns, the absolute number of both synaptic inputs and outputs for R7 and R8
          photoreceptors were in good agreement with previous reports analyzing a medulla-7-column
          connectome (<cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et al.</span><span>2015</span></a></cite>;
          <a href="#fig1s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1—figure
            supplement 2A-D</a>). As we had access to the complete brain volume, we additionally
          found substantial numbers of synapses in the axon bundles projecting between the lamina
          and the medulla, which accounted for 14% and 12% of the output synapses for R7 and R8,
          respectively, and 16% and 27% of their input synapses (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1F</a>, <a href="#fig1s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1—figure supplement 2G</a>).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">We readily identified columns
          in the DRA region of the medulla since it is only there that both inner photoreceptors
          terminate in medulla layer M6 (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1F</a>, arrow; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib75"><span>75</span><span>Pollack
                and Hofbauer</span><span>1991</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib19"><span>19</span><span>Fortini
                and Rubin</span><span>1991</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib81"><span>81</span><span>Sancer et
                al.</span><span>2019</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib5"><span>5</span><span>Chin et
                al.</span><span>2014</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib17"><span>17</span><span>Fischbach
                and Dittrich</span><span>1989</span></a></cite>). The morphology of DRA-specific
          Dm-DRA1 cells differs significantly between central and polar positions of the DRA <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib81"><span>81</span><span>Sancer et al.</span><span>2019</span></a></cite>,
          and we therefore chose one polar DRA seed column and two more equatorial columns (<a
            href="#fig1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1C</a>). Beyond
          the 27 DRA columns with manually traced R7-DRA and R8-DRA photoreceptors, we mapped the
          full extent of the DRA region of the medulla by systematically probing for the presence of
          two inner photoreceptor profiles in layer M6 without reconstruction (see Materials and
          methods), which resulted in a total of 42 identified DRA columns (<a href="#fig1"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1C</a>). Direct comparison
          of the absolute number of pre- versus postsynaptic sites between central and DRA
          photoreceptors revealed drastic differences: while the numbers of R7 and R7-DRA
          presynapses were comparable (mean 279, range 262–284 for R7-DRA versus mean 297, range
          274–322 for R7), the number of R8-DRA presynapses was reduced by ~60% compared to those of
          R8 (mean 166, range 157–172 for R8-DRA versus mean 380, range 356–417 for R8). In
          particular, there was a striking reduction in the number of synapses from R8-DRA to cells
          intrinsic to the medulla and to cells that projected to the lobula compared to R8 (see
          below and <a href="#fig1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1G
            and H</a>).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">This report is a comprehensive
          reconstruction of all inner photoreceptor synaptic outputs and inputs in our sample seed
          columns. The data set comprises cells that were identified and reconstructed because they
          are connected, by identifiable synapses, to our seed column inner photoreceptors. To be
          clear what this data set is not, it is not a reconstruction of all the cells, and the
          connections between them, in a volume around the seed columns.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">We have endeavored to make this
          comprehensive data set as accessible and navigable as possible. In the following sections
          we first describe the connections of the central column R7 and R8 cells (Figures 2–5),
          following the sequence of cell classes in <a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1G–H</a>, before presenting the
          connections of the DRA (Figures 6–9). For brevity, we refer to the region of the medulla
          innervated by DRA inner photoreceptors as the DRA region, and for clarity we refer to the
          central column inner photoreceptors as R7 and R8, and the DRA inner photoreceptors as
          R7-DRA and R8-DRA. The synaptic outputs from and inputs to the central pale and yellow
          R7–8 cells are summarized in Table 2, Table 3, for R7-DRA and R8-DRA in Table 4, Table 5,
          and presentations of individual cell types include summaries of total photoreceptor
          synapse counts (e.g. <a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1Eiii</a> for aMe12). The text highlights
          downstream cell types that are selective for inputs from either R7 or R8 or are
          preferentially found in pale or yellow columns. We used 65% as the threshold to consider
          an input selective and tables of connectivities of the individual cells are arranged by
          cell type and collected together in <a href="#supp1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 1</a>. The main figures show
          the morphology of reconstructed exemplars, with the many full reconstructions noted (and
          listed in Materials and methods), while the morphologies of individual cells are collected
          together in <a href="#supp2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 2</a>. The numbers of
          synapses outside the medulla are summarized in <a href="#supp3" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 3</a>. For the cell types for
          which we are unaware of published, detailed descriptions, we endeavored to produce light
          microscopic images of single cell clones which were matched largely based on the cell body
          location, neuropil-layer-specific branching patterns, and comparisons to any other known
          cell types (see Materials and methods). In a few cases, we also use light microscopy to
          illustrate specific features of known neurons or to explore additional properties (such as
          direct co-labeling with markers for pale and yellow columns) that are not readily
          accessible by EM. A key prior EM data set for comparison with our results is the medulla
          connectome of <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib97"><span>97</span><span>Takemura et al.</span><span>2017</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et al.</span><span>2015</span></a></cite>,
          fully released in <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib7"><span>7</span><span>Clements et al.</span><span>2020</span></a></cite>.
          We refer to this connectome as the ‘medulla-7-column connectome’. For ease of reference,
          all abbreviations used, including anatomical abbreviations, are listed in <a
            href="#table1" itemscope="" itemtype="http://schema.stenci.la/Link">Table 1</a>.</p>
        <table id="table1" itemscope="" itemtype="http://schema.org/Table">
          <caption><label data-itemprop="label">Table 1.</label>
            <div itemprop="caption">
              <h4 itemscope="" itemtype="http://schema.stenci.la/Heading" id="abbreviations-used">
                Abbreviations used.</h4>
            </div>
          </caption>
          <thead>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">Abbreviations used:</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell"></th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell"></th>
            </tr>
          </thead>
          <tbody>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">EM</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Electron microscopy</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">FAFB</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><em itemscope=""
                  itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> Full Adult Fly Brain
                data set (<cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                    href="#bib117"><span>117</span><span>Zheng et
                      al.</span><span>2018</span></a></cite>)</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">FIB-SEM</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Focused ion-bean serial
                electron microscopy</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla-7-column
                connectome</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">FIB-SEM data set of
                <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                    href="#bib97"><span>97</span><span>Takemura et
                      al.</span><span>2017</span></a></cite>; <cite itemscope=""
                  itemtype="http://schema.stenci.la/Cite"><a
                    href="#bib96"><span>96</span><span>Takemura et
                      al.</span><span>2015</span></a></cite>. Connectivity accessible through <cite
                  itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                    href="#bib7"><span>7</span><span>Clements et
                      al.</span><span>2020</span></a></cite>.</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">UV</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Ultraviolet</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">P</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Pale, for example, pR7
                are R7 photoreceptors of pale ommatidia</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Y</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Yellow, for example, yR8
                are R8 photoreceptors of yellow ommatidia</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Brain regions:</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">AME</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Accessory medulla</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">AOTU</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Anterior optic tubercle
              </td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">DRA</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dorsal rim area</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">FLA</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Flange</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">LO</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Lobula</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">IPS</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Inferior posterior slope
              </td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">LOP</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Lobula plate</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">SPS</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Superior posterior slope
              </td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">PLP</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Posterior lateral
                protocerebrum</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">L1-6</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Lobula layers 1–6</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">M1-10</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla layers 1–10</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">ME</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">CA</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mushroom body calyx</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Cell type names or part
                of cell type names:</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">aMe12</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Accessory medulla 12
              </td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">C2-3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Lamina centrifugal cell
                types</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Distal medulla cell
                class</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">-DRA</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Suffix indicating the
                cell type is located in the DRA</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">L1-5</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Lamina monopolar cell
                types</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">MeMe-DRA</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Cell type connecting
                ipsilateral medulla and contralateral medulla</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">MeTu</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla to anterior
                optic tubercle cell class</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla intrinsic cell
                class</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">ML</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla to lobula cell
                class</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">ML-VPN</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla to lobula visual
                projection neuron (named for similarity to ML cells)</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mti</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla tangential
                intrinsic cell class</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mt-VPN</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Medulla tangential
                visual projection neuron</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">OA-AL2i3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Octopaminergic neuron
                named by Busch et al. (2007)</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">R1-8</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Photoreceptor cell types
              </td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Transmedullary cell
                class (neurons connecting medulla and lobula)</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">TmY</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Transmedullary Y cell
                class (neurons connecting medulla, lobula, lobula plate)</td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">VPN</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Visual projection neuron
                (cell connecting optic lobe and central brain)</td>
            </tr>
          </tbody>
        </table>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig2" title="Figure 2.">
          <label data-itemprop="label">Figure 2.</label><img src="index.html.media/fig2.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="synapses-between-r7-and-r8-and-with-dm-neurons-in-the-non-dorsal-rim-area-dra-medulla">
              Synapses between R7 and R8, and with Dm neurons in the non-dorsal rim area (DRA)
              medulla.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Synapses between central R7
              and R8 cells. Left: Side view of R7 (purple) and R8 (green), with R7→R8 synapses
              (purple points) and R8→R7 synapses (green points). Note synapses outside the medulla
              neuropil (distal to layer M1). Scale bar: 10 μm. Right: Synapse distribution (in
              synapses/μm) in the yellow and pale seed columns. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Synapses between R7 and R8 and
              Dm9 cells. (Bi) Top view of a fully reconstructed Dm9 skeleton (gray) covering all
              four central seed columns (darker shading) with all R7 (purple) and R8 (green) inputs.
              (Bii) Left: Side view of R7 (purple) and R8 synapses (green) to the same Dm9 cell
              across medulla layers. Right: Layer distribution of photoreceptor inputs to six Dm9
              cells. (Biii) Left: Side view of Dm9→ R7 (purple) and Dm9→R8 (green) feedback synapses
              from the same Dm9 cell. Right: Layer distribution of feedback synapses from six Dm9
              occupying the seed columns. Most of these synapses are from the illustrated Dm9 cell
              with other Dm9 cells contributing a small number of connections in M1 and M6. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">C</strong>) Synapses between
              R7 and Dm8 cells. (Ci): Left: Side view of R7 synapses (purple) to a fully
              reconstructed Dm8 cell, with one pale R7 cell is shown in purple. Note the
              characteristic vertical projections of Dm8 in its ‘home column’ (arrow; yellow R7 cell
              not shown). Right: Layer distribution of R7 inputs from 14 Dm8 cells innervating the
              four seed columns. (Cii) Full reconstructions of three Dm8 cells (labeled 1, 2, 3)
              innervating the four seed columns, with all R7 synapses (purple), including inputs
              beyond the seed columns. Individual Dm8 home columns (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">h</strong>) are marked. (Ci–ii) Scale
              bars: 10 μm. (Ciii) R7→Dm8 synapses/μm as a function of their distance from the home
              column, for the three Dm8 cells (1, 2, 3 above). The cells receive dense innervation
              in their home column and weaker inputs from both pale and yellow R7 cells in their
              periphery. (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">D</strong>)
              Synapses between R7 and Dm11 cells with R7 (purple) and R8 (green) synapses from seed
              columns. (Di) Top view of a reconstructed Dm11 skeleton. (Dii) Left: Side view of the
              layer distribution of photoreceptor synapses, including synapses outside the medulla
              (arrow). (Di–ii) Scale bars: 10 μm. Right: Layer distribution of R7 and R8 inputs to
              three Dm11 cells. (Diii) Rendering of a confocal image of MultiColor FlpOut (MCFO)
              labeled Dm11 cells. Note the characteristic vertical projections leaving the medulla
              neuropil (arrow). The dashed line marks the approximate boundary of the medulla
              neuropil. Scale bar: 20 μm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">E</strong>) Synapses between R7 and R8 and
              Dm2 cells. (Ei) Top view of a Dm2 skeleton, with R7 (purple) and R8 (green) synapses.
              (Eii) Left: Side view of layer distribution of photoreceptor synapses onto the same
              Dm2 cell. (Ei–ii) Scale bars: 10 μm. Right: Layer distribution of R7 and R8 inputs to
              four Dm2 cells.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig2s1"
          title="Figure 2—figure supplement 1."><label data-itemprop="label">Figure 2—figure
            supplement 1.</label><img src="index.html.media/fig2-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="lamina-cell-types-targeted-by-central-column-r78">Lamina cell types targeted by
              central column R7–8.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Left: Side view of a
              reconstructed L1 cell (gray) with R8→L1 synapses (green). Right: Layer distribution
              (in synapses/μm) of all R7 and R8 inputs to four L1 cells. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Left: Side view of a
              reconstructed L3 cell (gray), with R7→L3 (purple) and R8→L3 synapses (green). Right:
              Layer distribution (in synapses/μm) of all R7 and R8 inputs to four L3 cells.(<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong"> C</strong>) Left: Side view
              of a reconstructed C2 cell (gray), with R7→C2 (purple) and R8→C2 synapses (green).
              Right: Layer distribution (in synapses/μm) of all R7 and R8 inputs to two C2 cells.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">A–C</strong>) All
              scale bars: 10 μm.</p>
          </figcaption>
        </figure>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="synapses-between-r7-and-r8-and-with-lamina-cell-types">Synapses between R7 and R8, and
          with lamina cell types</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The inner photoreceptors
          inhibit each other via histaminergic synapses, a key mechanism for converting their
          sensitivity to specific wavelengths into presynaptic color opponency <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib86"><span>86</span><span>Schnaitmann et
                al.</span><span>2018</span></a></cite>. We annotated a large proportion of the
          synapses between R7 and R8 along the axons between the lamina and the medulla (<a
            href="#fig2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 2A</a>, <a
            href="#fig1s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1—figure
            supplement 2G</a>). For R8, ~80% of the synaptic input from R7 was found outside the
          medulla (mean 11.5 synapses per cell, range 9–17), and the R8 inputs to R7 in this region
          were as frequent (mean 10.3 synapses per cell, range 5–13). These results were not
          anticipated by prior EM reconstructions of individual neuropils, and our counts are
          substantial increases in the numbers of inter-photoreceptor synapses (<a href="#fig1s2"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1—figure supplement 2D</a>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et al.</span><span>2015</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib52"><span>52</span><span>Meinertzhagen and
                O’Neil</span><span>1991</span></a></cite>).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">R7–8 pass through the lamina
          without forming synapses <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib52"><span>52</span><span>Meinertzhagen and
                O’Neil</span><span>1991</span></a></cite>, and instead form synapses with lamina
          cell types in the medulla <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib94"><span>94</span><span>Takemura
                  et al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib95"><span>95</span><span>Takemura
                  et al.</span><span>2013</span></a></cite></span>. Our reconstructions revealed
          that 58% of R7–8 inputs to the lamina cells L1 and L3 were also located within the optic
          chiasm (<a href="#fig1s1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            1—figure supplement 1B</a>, <a href="#fig1s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1—figure supplement 2G</a>, <a
            href="#fig2s1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 2—figure
            supplement 1A, B</a>).</p>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="r78-synapses-with-distal-medulla-cell-types">R7–8 synapses with distal medulla cell
          types</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The distal medulla (Dm) neurons
          included the strongest targets of R7–8 (<a href="#table2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Table 2</a>). Dm9 is glutamatergic and provides
          excitatory feedback to R7 and R8, regulating their gain and augmenting their color
          opponency <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib10"><span>10</span><span>Davis et
                  al.</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib101"><span>101</span><span>Uhlhorn and
                  Wernet</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib24"><span>24</span><span>Heath et
                  al.</span><span>2020</span></a></cite></span>. It accounted for more than 90% o
          all the synaptic inputs to R7–8 that were not from photoreceptors (333/369 synapses, <a
            href="#table3" itemscope="" itemtype="http://schema.stenci.la/Link">Table 3</a>). Dm9
          cells span multiple columns and tile the medulla (<cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib60"><span>60</span><span>Nern et
                al.</span><span>2015</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                et al.</span><span>2015</span></a></cite>; <a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2B</a>). We reconstructed six Dm9 cells
          that were contacted by our seed column R7–8s, which received 16% of all R7–8 synapses, and
          provided 57% of the total seed column photoreceptor synaptic input (<a href="#table2"
            itemscope="" itemtype="http://schema.stenci.la/Link">Table 2</a>, <a href="#table3"
            itemscope="" itemtype="http://schema.stenci.la/Link">Table 3</a>). Of the six Dm9 cells,
          one cell occupied our seed columns and formed the bulk of the synapses between R7–8 and
          Dm9 in these columns. The other five cells received far fewer connections and only in
          medulla layers M1 and M6. The well-connected Dm9 cell that we fully reconstructed received
          92 synapses per seed column (mean, range 78–102), and provided 70 synapses per seed column
          (mean, range 64–78) offering the most detailed picture of Dm9 connectivity yet (<a
            href="#supp1" itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary file
            1</a> – Dm9 outgoing). While its R7–8 inputs were biased toward R8 (31% R7 versus 69%
          R8), the output synapses were balanced (55% R7 versus 45% R8), and pale and yellow columns
          were equally contacted (outputs from R7 and R8: 54% pale versus 46% yellow; inputs from R7
          and R8: 53% pale versus 47% yellow). In total, 8% of the synapses from R7–8 to Dm9 were
          outside the medulla (34/445 of all R7–8 synapses onto Dm9), on processes following the
          photoreceptor axons (<a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Bii</a>, arrow).</p>
        <table id="table2" itemscope="" itemtype="http://schema.org/Table">
          <caption><label data-itemprop="label">Table 2.</label>
            <div itemprop="caption">
              <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
                id="synaptic-targets-of-seed-columns-r7-and-r8">Synaptic targets of seed columns R7
                and R8.</h4>
            </div>
          </caption>
          <thead>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">Type</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">No.</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">pR7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">yR7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">pR8</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">yR8</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">Sum</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%R7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%R8</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%p</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%y</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%Total</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%Total_R7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%Total_R8</th>
            </tr>
          </thead>
          <tbody>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm9</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">94</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">66</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">142</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">143</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">445</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">36</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">64</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">53</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">47</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">16.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">13.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">18.8</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm8</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">15</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">235</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">161</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">396</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">59.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">40.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">33.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">MeTu</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">82</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">93</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">175</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">46.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">53.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">R7</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">75</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">82</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">160</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">98.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">46.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">53.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">10.3</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm5c</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">20</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">103</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">140</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">12.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">87.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">20</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">80</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">8.1</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm20</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">67</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">65</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">140</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">94.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">51.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">48.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">8.7</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi15</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">38</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">81</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">132</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">9.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">90.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">33.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">66.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7.8</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi4</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">58</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">58</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">116</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7.6</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">ML1</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">58</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">41</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">99</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">58.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">41.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6.5</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm2</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">18</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">60</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">15</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">96</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">21.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">78.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">81.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">18.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4.9</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm11</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">28</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">27</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">63</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">87.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">12.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">49.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.5</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">L3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">19</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">17</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">12</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">13</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">61</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">59</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">41</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">49.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.6</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi1</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">31</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">28</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">59</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">52.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">47.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3.9</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">R8</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">31</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">58</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">98.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">55.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">44.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.1</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm5a</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">53</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">53</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm5b</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">39</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">48</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">81.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">18.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">87.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">12.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.6</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">17</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">16</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">44</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">47.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">52.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">54.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">45.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.5</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm5b-like</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">27</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">41</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">34.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">65.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.8</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi9</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">39</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">30.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">69.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">74.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">25.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.8</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">L1</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">21</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">38</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">92.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">60.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">39.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2.3</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">aMe12</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">30</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">13.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">86.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.7</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">11</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">29</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">62.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">37.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">58.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">41.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.7</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">ML_VPN1</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">27</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">96.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.8</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">C2</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">13</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">76.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">23.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.4</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mt_VPN</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">12</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">23</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">52.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">47.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">13</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">87</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.7</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mti</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">10</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">19</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">10.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">89.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">63.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">36.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.1</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Tm5a-like</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">16</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">17</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">94.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.1</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">TmY10</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">85.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.4</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi10</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mi</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">66.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">33.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">C3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.2</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Identified_ &lt; 3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">14</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">37</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">51.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">48.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">51.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">48.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.2</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Unidentified_ ≥ 3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">62.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">37.5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.5</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Unidentified_ &lt; 3
              </td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">62</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">15</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">22</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">24</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">70</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">34.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">65.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">44.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">55.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Total</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">211</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">628</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">559</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">747</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">773</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">2,707</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">43.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">56.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">49.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
            </tr>
          </tbody>
        </table>
        <table id="table3" itemscope="" itemtype="http://schema.org/Table">
          <caption><label data-itemprop="label">Table 3.</label>
            <div itemprop="caption">
              <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
                id="cells-that-synapse-onto-seed-columns-r7-and-r8">Cells that synapse onto seed
                columns R7 and R8.</h4>
            </div>
          </caption>
          <thead>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">Type</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">No.</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">pR7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">yR7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">pR8</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">yR8</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">Sum</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%R7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%R8</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%p</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%y</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%Total</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%Total_R7</th>
              <th itemscope="" itemtype="http://schema.stenci.la/TableCell">%Total_R8</th>
            </tr>
          </thead>
          <tbody>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Dm9</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">90</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">92</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">79</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">72</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">333</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">54.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">45.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">49.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">57</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">51.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">65.9</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">R8</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">75</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">82</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">158</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">99.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">48.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">51.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">27.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">44.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.4</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">R7</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">31</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">26</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">57</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">54.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">45.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">9.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">24.9</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Mt_VPN</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">40</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">60</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.3</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">C2</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">40</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">60</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.9</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">L3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.7</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Identified_ &lt; 3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">11</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">18</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">33.3</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">66.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">44.4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">55.6</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">3.1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">5.2</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Unidentified_ ≥ 3</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Unidentified_ &lt; 3
              </td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">1</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">4</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">75</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">25</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.7</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">0.4</span></td>
            </tr>
            <tr itemscope="" itemtype="http://schema.stenci.la/TableRow">
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell">Total</td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">32</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">172</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">183</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">120</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">109</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">584</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">60.8</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">39.2</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">50</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
              <td itemscope="" itemtype="http://schema.stenci.la/TableCell"><span
                  data-itemtype="http://schema.org/Number">100</span></td>
            </tr>
          </tbody>
        </table>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The most strongly connected R7
          target cell type was Dm8, a central component of <em itemscope=""
            itemtype="http://schema.stenci.la/Emphasis">Drosophila</em>’s circuitry mediating color
          vision and wavelength-specific phototaxis <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib55"><span>55</span><span>Melnattur et
                  al.</span><span>2014</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib68"><span>68</span><span>Pagni et
                  al.</span><span>2021</span></a></cite></span>. Individual Dm8 cells cover multiple
          columns in medulla layer M6 <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib60"><span>60</span><span>Nern et
                  al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib47"><span>47</span><span>Luo et
                  al.</span><span>2020</span></a></cite></span>, and extend processes vertically,
          with one characteristic process usually reaching higher than the others, up to layer M3,
          defining a so-called ‘home’ column (<a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Ci</a>, arrow). In our reconstructions,
          we analyzed the connectivity of each Dm8 cell with the surrounding pale and yellow R7
          photoreceptors in relation to its home column.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Dm8 cells were exclusively R7
          targets, with no synapses from our seed column R8s. Individual R7 cells synapsed onto
          eight Dm8 cells (mean, range 6–10), contacting 15 Dm8s altogether, and there were five Dm8
          cells with processes spanning our seed column R7s and receiving &gt;40 synapses from them.
          Two of these cells had a pale home column and no input from yellow seed column R7s, and
          two had a yellow home column and received 13% and 20% of their seed column input from pale
          R7s (<a href="#supp1" itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary
            file 1</a> – Dm8 outgoing). The fifth cell had a pale home column outside the seed
          column area, and its seed column inputs were divided evenly, 55% from pale and 45% from
          yellow. Collectively, these data revealed that Dm8 cells selectively innervated columns
          around the home column, but not simply the closest columns.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">In view of the importance of
          Dm8 cells for processing R7 output, we extended our reconstructions to include all the
          photoreceptor inputs to three Dm8s, one with a pale home seed column, one with a yellow
          home seed column, and one with a yellow home column outside the seed columns (<a
            href="#fig2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 2Cii</a>). All
          three cells were most densely innervated by R7 in their home column: the yellow home
          column cells received 26% and 23% of their R7 input in the home column, and the pale home
          column cell received 52% (<a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Ciii</a>). The innervated columns
          outside the home column were not the nearest neighbors of the home column, but formed a
          more irregular, idiosyncratic spatial pattern. Together, our data are consistent with Dm8
          cells having a central, strong R7 input from either a pale or a yellow cell in its home
          column and a surround that integrates spatially varied pale and yellow R7 inputs.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Two additional Dm cell types,
          Dm11 and Dm2, were prominent inner photoreceptor targets. Dm11 cells tile the medulla in
          layer M6, with each cell covering ~9 columns (<cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib60"><span>60</span><span>Nern et
                al.</span><span>2015</span></a></cite>; <a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Di</a>), and sending vertical processes
          that reach far up into the optic chiasm, tracking the R7 and R8 photoreceptor axons (<cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib8"><span>8</span><span>Courgeon and
                Desplan</span><span>2019</span></a></cite>; <a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Dii</a>, Diii, arrows). Dm11 was
          R7-selective, with 87% of its seed column photoreceptor inputs originating from R7s (<a
            href="#fig2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 2Dii</a>).
          Two-thirds of the Dm11 seed column R7–8 inputs were located outside of the medulla (44/63
          synapses), and this was another cell type innervated by photoreceptors much more than
          previously reported (<a href="#fig1s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1—figure supplement 2D</a>; <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib7"><span>7</span><span>Clements et al.</span><span>2020</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et
                al.</span><span>2015</span></a></cite>). One Dm11 cell squarely occupied the four
          seed columns, receiving 52 synapses from the seed column photoreceptors, and this cell
          showed no clear bias for pale or yellow inputs (40% pale, 60% yellow; <a href="#supp1"
            itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary file 1</a> – Dm11
          outgoing).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Dm2 is a columnar cell type
          that spans one to two columns and has processes that reach from layer M6 up to layer M3 to
          receive synaptic input from R8 cells (<a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Ei</a>, Eii; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib95"><span>95</span><span>Takemura
                et al.</span><span>2013</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib60"><span>60</span><span>Nern et
                al.</span><span>2015</span></a></cite>). We reconstructed four Dm2s that received
          77% of their seed column photoreceptor input from R8 (<a href="#fig2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 2Eii</a>) and 81% from pale cells. Three
          of the Dm2 cells were centered on seed columns, with two in the pale seed columns
          receiving 36 and 35 synapses, and the cell in a yellow seed column receiving 18; the
          fourth cell was centered on a neighboring yellow column and innervated one of the pale
          seed columns (<a href="#supp2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 2</a> – Dm2). In the columns
          of the medulla-7-column connectome that have been identified as pale and yellow <span
            itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib56"><span>56</span><span>Menon et
                  al.</span><span>2019</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                  et al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib7"><span>7</span><span>Clements
                  et al.</span><span>2020</span></a></cite></span>. The cell was missing from one of
          the pale columns in that data set <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                et al.</span><span>2015</span></a></cite>, but in the columns where it was present,
          the cells received ~50% more synapses per column in the pale columns (18 mean, range 16–20
          in pale columns, versus 12, mean, range 10–15 in yellow columns).</p>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="r78-synapses-with-medulla-intrinsic-and-medulla-tangential-intrinsic-cell-types">R7–8
          synapses with medulla intrinsic and medulla tangential intrinsic cell types</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The medulla intrinsic (Mi)
          cells connect the distal with the proximal medulla <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib17"><span>17</span><span>Fischbach
                and Dittrich</span><span>1989</span></a></cite>. These two medulla zones are
          separated by the serpentine layer M7, containing the processes of large medulla tangential
          cells, including those intrinsic to the medulla which we refer to as medulla tangential
          intrinsic (Mti) cells. There were three Mti cells contacted by our seed column R7–8, and
          we matched these cells to light microscopy images of two separate, previously undescribed
          cell types using the locations of cell bodies, sizes of arbors and layer expression (<a
            href="#fig3" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 3</a>; <a
            href="#fig3" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 3A and B</a>).
          Both cell types received a modest number of synapses from our seed column R7–8 (Mti1: 7
          synapses; Mti2: 10 and 2 synapses, respectively; <a href="#supp1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 1</a> – Mti outgoing), yet
          were likely to be substantial targets overall since their processes covered large sections
          of the medulla (<a href="#fig3" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 3A and B</a>). The first cell type, which
          we refer to as Mti1, had a cell body located distally to the medulla, in the cell body
          layer, similar to most medulla neurons. Its processes were asymmetrically oriented mainly
          along the dorsoventral axis, with dendrites that occupied layers M3–M6, and axonal
          processes oriented dorsoventrally that spread laterally in layers M7–M8 (<a href="#fig3"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 3A</a>). The second cell
          type, here named Mti2 (<a href="#fig3" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 3B</a>), had cell bodies located at the
          anterior ventral edge of the medulla, adjacent to where its processes entered and coursed
          through layer M7 going on to make elaborations in layer 6 and small, further vertical
          processes that reach vertically up to layers M3 and M4 (<a href="#fig3" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 3Biii</a> and 3Bvi, arrows). In our EM
          reconstructions, two cells shared these properties and overlapped around our seed columns
          (<a href="#fig3" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 3Bv</a>).
          From light microscopy, we estimate there are ~50 Mti2 cells. However, we note that the
          driver line used for this estimate may include related but distinct cell types with a
          similar cell body location or might not label all Mti2 cells.</p>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig3" title="Figure 3.">
          <label data-itemprop="label">Figure 3.</label><img src="index.html.media/fig3.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="r78-synapses-with-medulla-intrinsic-mi-and-medulla-tangential-intrinsic-mti-cell-types">
              R7–8 synapses with medulla intrinsic (Mi) and medulla tangential intrinsic (Mti) cell
              types.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Synapses of central R7 and R8
              with Mti1 cells. (Ai) Top view of an Mti1 skeleton with synapses from seed column R8
              cells (green). Scale bar: 10 μm. (Aii) Top view of an MCFO-labeled cell matching
              overall Mti1 morphology. Light microscopy images (Aii, Aiv, Bii, Biv, Ciii) were
              manually segmented to focus on the cells of interest. Scale bar: 20 μm. (Aiii) Side
              view of the same Mti1 cell as in Ai with R8 (green) synapses. Scale bar: 10 μm. (Aiv)
              Side view rendering of the same light microscopy Mti1 image (green). Scale bar: 20 μm.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>) Synapses
              from R7 and R8 to Mti2. (Bi) Top view of a reconstructed Mti2 cell, with R7 (purple)
              and R8 (green) synapses. Scale bar: 10 μm. (Bii) Top view of an MCFO-labeled cell
              matching overall Mti2 morphology. Scale bar: 20 μm. (Biii) Side view of the same Mti2
              skeleton as in Bi with R7 (purple) and R8 (green) synapses on characteristic vertical
              projections (arrow). Scale bar: 10 μm. (Biv) Side view of the cell shown in Bii. Arrow
              indicates vertical projections. Scale bar: 20 μm. (Bv) Top view of a second
              reconstructed Mti2 cell (dark gray) overlayed on the first (light gray), with R8
              (green) synapses. Bvi: Side view of the second Mti2 skeleton, with R8 (green) synapses
              again located on vertical projections (arrow). (Bv–vi) Scale bars: 10 μm. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">C</strong>) Synapses of R7
              and R8 with Mi15 cells. (Ci) Top view of a fully reconstructed Mi15 skeleton, with R7
              (purple) and R8 (green) synapses. (Cii) Left: Side view depicting the layer
              distribution of photoreceptor synapses (same color code) onto the same Mi15 skeleton,
              with synapses outside the medulla (arrow). (Ci–ii) Scale bars: 10 μm. Right: Layer
              distribution of R7 and R8 inputs to four Mi15 cells. (Ciii) Side view rendering of a
              light microscopy image (MCFO) of an Mi15 cell. Note the long process leaving the
              medulla (arrow). Scale bar: 10 μm.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig3s1"
          title="Figure 3—figure supplement 1."><label data-itemprop="label">Figure 3—figure
            supplement 1.</label><img src="index.html.media/fig3-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="mi-cell-types-targeted-by-r78">Mi cell types targeted by R7–8.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Colocalization of R8→Mi15
              synapses with R8→R7 synapses. (Ai) Example electron microscopy (EM) image of Mi15 and
              R7 cells as postsynaptic partners of the same R8 presynapse. Scale bar: 1 μm. (Aii)
              Magnified view of skeletons of R8, Mi15, and R7 cells in the optic chiasm,
              illustrating the colocalization of R8→Mi15 synapses with R8→R7 synapses at five
              successive locations. Scale bar: 1 μm.(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Left: Side view of a
              reconstructed Mi1 cell (gray) with R7→Mi1 (purple) and R8→Mi1 synapses (green). Right:
              Layer distribution (in synapses/μm) of all R7 and R8 inputs to four Mi1 cells.(<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">C</strong>) Left: Side view
              of a reconstructed Mi4 cell (gray) with R7→Mi4 (purple) and R8→Mi4 synapses (green).
              Right: Layer distribution (in synapses/μm) of all R7 and R8 inputs to four Mi4
              cells.(<strong itemscope="" itemtype="http://schema.stenci.la/Strong">D</strong> )
              Left: Side view of a reconstructed Mi9 cell (gray) with R7→Mi9 (purple) and R8→Mi9
              synapses (green). Right: Layer distribution (in synapses/μm) of all R7 and R8 inputs
              to four Mi9 cells. In the pale seed columns, Mi9 cells received many R8 synapses, but
              only received one R8 synapse in the yellow seed columns.(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong"> B–D</strong>) Scale bars: 10 μm.</p>
          </figcaption>
        </figure>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Mi15 is the only local
          dopaminergic medulla cell type identified in <em itemscope=""
            itemtype="http://schema.stenci.la/Emphasis">Drosophila</em> so far <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib54"><span>54</span><span>Meissner
                  et al.</span><span>2019</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib10"><span>10</span><span>Davis et
                  al.</span><span>2020</span></a></cite></span>. Its morphology and connectivity in
          the medulla have been described previously <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib95"><span>95</span><span>Takemura
                  et al.</span><span>2013</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                  et al.</span><span>2015</span></a></cite></span>, and it has a long process that
          extends into the optic chiasm and tracks photoreceptor axons. Our reconstructions revealed
          that this process was a locus of photoreceptor input (<a href="#fig3" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 3Cii</a>, black arrow), and that Mi15
          cells were R8-selective, with 91% of their seed column photoreceptor input drawn from R8.
          The Mi15 cells received 47% of their seed column photoreceptor input outside the medulla
          (mean of 15/32 synapses per column; <a href="#fig1s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1—figure supplement 2G</a>), and R8s
          characteristically formed synapses with Mi15 cells at locations where they also made
          synapses with R7 (<a href="#fig3s1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 3—figure supplement 1A</a>).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The columnar cell types Mi1,
          Mi4, and Mi9 are integral components of the ON-motion pathway <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib91"><span>91</span><span>Strother
                et al.</span><span>2017</span></a></cite>; prior EM reconstructions have found they
          receive significant input from R7 and R8, a result confirmed by our data (<cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib95"><span>95</span><span>Takemura et al.</span><span>2013</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et al.</span><span>2015</span></a></cite>;
          <a href="#fig3s1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 3—figure
            supplement 1B-D</a>). In the identified pale and yellow columns of the medulla-7-column
          connectome, Mi9 was selective for R8 (65% R8 versus 35% R7 input), and 53% of its
          photoreceptor input originated from pale R8 <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                et al.</span><span>2015</span></a></cite>. Our data reinforced the observation that
          Mi9 show a bias for R8 input: 68% of our reconstructed Mi9 input originated from pale seed
          column R8; the cells in pale columns received 15 and 14 R7–8 synapses, while those in
          yellow columns received 6 and 4 (<a href="#fig3s1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 3—figure supplement 1D</a>).</p>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="r78-synapses-with-cell-types-projecting-to-the-lobula">R7–8 synapses with cell types
          projecting to the lobula</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The lobula receives diverse
          inputs from the medulla, including from cell types required for wavelength-specific
          phototaxis and learned color discrimination <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib34"><span>34</span><span>Karuppudurai et
                  al.</span><span>2014</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib55"><span>55</span><span>Melnattur et
                  al.</span><span>2014</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib66"><span>66</span><span>Otsuna
                  et al.</span><span>2014</span></a></cite></span>. Many of these cell types express
          the histamine receptor <em itemscope=""
            itemtype="http://schema.stenci.la/Emphasis">ort</em>, notably the transmedulla (Tm) cell
          types Tm5a, Tm5b, Tm5c, and Tm20 <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                al.</span><span>2008</span></a></cite>, indicating they receive direct input from
          the histaminergic R7 or R8 <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib70"><span>70</span><span>Pantazis et al.</span><span>2008</span></a></cite>.
          We found all of these Tm cell types and they were highly connected with the seed column
          R7–8, with a mean of 35 seed column photoreceptor inputs per cell for Tm20, 27 for Tm5a,
          23 for Tm5c, and 24 for Tm5b (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4</a>, <a href="#fig4s1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4—figure supplement 1</a>).</p>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig4" title="Figure 4.">
          <label data-itemprop="label">Figure 4.</label><img src="index.html.media/fig4.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="r78-synapses-with-cell-types-projecting-to-the-lobula-1">R7–8 synapses with cell
              types projecting to the lobula.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A–D</strong>) Synapses between R7 and R8
              and Tm5a (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">A</strong>),
              Tm5b (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>),
              Tm5c, (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">C</strong>) and
              ML1 (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">D</strong>) cell
              types. R7 synapses are indicated in purple, R8 synapses in green. Scale bars: 10 µm.
              Panels i–iii: Anatomy of fully reconstructed cells. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">i</strong>) Side view. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">ii</strong>) Top view.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">iii</strong>) Side
              view of axon terminals in the lobula. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">iv</strong>) Left: Side view of medulla
              branches. Right: Layer distribution of R7 and R8 inputs. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Tm5a. Two Tm5a cells were
              exclusively targeted by yellow R7 cells.(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong"> B</strong>) Tm5b. The two Tm5b cells were
              highly biased to pale R7 inputs. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Tm5c. The five Tm5c cells were
              highly biased to yellow R8 inputs. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) ML1. Scale bars: 20 µm.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">Dv</strong>) Side view
              of a single MCFO-labeled ML1 cell (light microscopy). Note this cell has terminals
              both at the base of the deepest lobula layer and in the central brain; not all
              examined ML1 cells have terminals in the central brain. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">Dvi</strong>) Side view showing the
              distribution of a membrane marker (green) and presynaptic marker (synaptotagmin-HA,
              purple) in ML1 cells imaged as a population. The combined patterns (left) and the
              presynaptic marker alone (right) are shown. Arrow indicates central brain terminals.
            </p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig4s1"
          title="Figure 4—figure supplement 1."><label data-itemprop="label">Figure 4—figure
            supplement 1.</label><img src="index.html.media/fig4-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="additional-connections-of-r78-to-cell-types-projecting-to-the-lobula">Additional
              connections of R7–8 to cell types projecting to the lobula.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A–D</strong>) Synapses between R7 and R8
              and Tm5a-like (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>), Tm5b-like (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>), and Tm20
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">C</strong>) cell
              types. R7 synapses are indicated in purple, R8 synapses in green. Scale bars: 10 µm.
              Panels i–iii: Anatomy of fully reconstructed cells. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">i</strong>) Side view. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">ii</strong>) Top view.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">iii</strong>) Side
              view of axon terminals in the lobula. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">iv</strong>) Left: Side view of medulla
              branches. Right: Layer distribution of R7 and R8 inputs. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) R7 and R8 connections with the
              Tm5a-like cell, which has a morphology similar to a Tm5a cell, but a different pattern
              of connectivity. The same reconstructed cell is shown in Ai–iii. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) R7 and R8 connections with
              three Tm5b-like cells, that each have a morphology similar to a Tm5b cell, but a
              different, shared pattern of connectivity. The same reconstructed Tm5b-like cell is
              shown in Bi–iii. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) R7 and R8 connections with
              Tm20 cells. The same reconstructed Tm20 cell is shown in Ci–iii.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig4s2"
          title="Figure 4—figure supplement 2."><label data-itemprop="label">Figure 4—figure
            supplement 2.</label><img src="index.html.media/fig4-figsupp2.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="ml1-arbor-distribution-in-the-medulla-and-lobula">ML1 arbor distribution in the
              medulla and lobula.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Scale bars in (Ai,Aii)
              represent 20 µm. The other panels are shown at a similar scale. Images show views
              generated from image stacks (see Materials and methods). Images show a top view of the
              array of column in the lobula (top panels, lower part of each image) or the medulla
              (lower panels), respectively. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) As a population, ML1 cells
              appear not to cover all visual columns in the lobula (Ai) but do cover the entire
              medulla (Aii). Note absence of the green ML1 membrane label near the dorsal and
              ventral margin of the lobula but not the medulla. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B,C</strong>) Lobula (Bi,Ci) and medulla
              (Bii,Cii) arbors of two groups of MCFO-labeled ML1 cells. The retinotopic array of ML1
              cells in the medulla (Bii,Cii) is only partly reflected in the positions of their axon
              terminals (Bi,Ci) in or near the lobula. For example, cells near the medulla edge have
              terminals away from the margin of the lobula.</p>
          </figcaption>
        </figure>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The cholinergic Tm5a cell type
          was the first cell type described to show yellow versus pale selectivity, being
          preferentially innervated by yellow R7, as revealed by genetic methods and light
          microscopy <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite>. It was identified in the medulla-7-column
          connectome <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib56"><span>56</span><span>Menon et al.</span><span>2019</span></a></cite> and
          used for identifying putative yellow columns therein (see Materials and methods). Its
          medulla processes are centered on one yellow column, with a single main dendrite from
          which branches spread laterally reaching some of the neighboring columns in M3, M6, and
          M8, and an axon terminating in lobula layer 5B manifesting a characteristically hooked
          final reversal of direction (<cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib21"><span>21</span><span>Gao et al.</span><span>2008</span></a></cite>; <a
            href="#fig4" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4A</a>). In
          both our yellow seed columns there was a Tm5a cell, whose seed column photoreceptor input
          was exclusively from the R7 in the home column (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4Aiv</a>). Reassuringly, there were also
          no Tm5a cells centered on pale columns or innervated by pale photoreceptors. Thus, the
          Tm5a cells supported the designation of our seed columns as pale or yellow, which was
          based on the presence or absence of aMe12 vertical processes. One more cell that we refer
          to as a Tm5a-like had the morphological features of a Tm5a cell, and was selective for
          yellow seed column input, but from R8 (<a href="#fig4s1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4—figure supplement 1A</a>). There was no
          cell with a similar morphology or connectivity in the medulla-7-column connectome, as
          explored using NeuPrint <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib7"><span>7</span><span>Clements et al.</span><span>2020</span></a></cite>.
          The cell received its R8 input on three different dendritic branches, indicating that they
          were unlikely to have resulted from a reconstruction error (<a href="#fig4s1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4—figure supplement 1A</a> iv). Overall,
          our results confirmed the selectivity of Tm5a cells for yellow columns and the reliability
          of finding R7-selective Tm5a cells in yellow columns.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The cholinergic Tm5b cell type
          is similar to Tm5a, but with <sub itemscope=""
            itemtype="http://schema.stenci.la/Subscript">2–3 vertical main dendrites spanning
          </sub>5 columns, from which branches spread laterally in M3, M6, and M8 (<cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib21"><span>21</span><span>Gao et al.</span><span>2008</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib53"><span>53</span><span>Meinertzhagen et
                al.</span><span>2009</span></a></cite>; <a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4B</a>). A recent analysis of the
          medulla-7-column connectome has proposed that Tm5b cells are pale-specific <cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib56"><span>56</span><span>Menon et al.</span><span>2019</span></a></cite>.
          Our reconstructions revealed two Tm5b cells that were innervated by pale R7, and not
          yellow R7 (<a href="#fig4" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            4B</a>), with only a minor input from seed column R8 (19 and 20 R7 inputs, versus 7 and
          2 R8 inputs, respectively). We also identified three more cells with a morphology matching
          the Tm5b cell type, but innervated by predominantly yellow inputs, which we refer to as
          Tm5b-like (<a href="#fig4s1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            4—figure supplement 1B</a>). In these yellow-specific cells, R8 input dominated, with
          9.0 R8 synapses (mean, range 4–16), versus 4.7 R7 synapses (mean, range 3–7; <a
            href="#fig4s1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4—figure
            supplement 1B</a> iv). In particular, one Tm5b-like cell had &gt;20 synapses, and
          innervated all four seed columns, and so was well covered in our reconstructions (<a
            href="#fig4s1" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4—figure
            supplement 1B</a>).</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The Tm5c cells are
          glutamatergic neurons, spanning ~8 columns with single vertical dendrite in the medulla,
          from which lateral branches spread out in M1, as well as M3 and M6, while the axons
          terminate near the boundary between lobula layers 5 and 6, often with a branch in layer 4
          (<cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib21"><span>21</span><span>Gao et al.</span><span>2008</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a
              href="#bib53"><span>53</span><span>Meinertzhagen et
                al.</span><span>2009</span></a></cite>; <a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4C</a>); one cell axon terminated deep in
          layer 6 (<a href="#supp2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 2</a> – Tm5c). Our
          reconstructions confirmed they were selective for R8, as indicated previously (<cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib95"><span>95</span><span>Takemura et al.</span><span>2013</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et al.</span><span>2015</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib34"><span>34</span><span>Karuppudurai et
                al.</span><span>2014</span></a></cite>; <a href="#fig1s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1—figure supplement 2D</a>). Six Tm5c
          cells were innervated by seed column photoreceptors, and they all received many synapses
          from multiple columns, ranging from 11 to 44, consistent with R7–8 input over a large
          spatial receptive field. One Tm5c was centered on our seed columns, with processes in all
          of them (<a href="#fig4" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            4Cii</a>), and only targeted by yellow seed column photoreceptors, predominantly R8.
          This bias toward yellow R8 inputs was maintained over the population (<a href="#fig4"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4Civ</a>), yet there were
          two Tm5c cells with pale selectivity, and it remains possible that different Tm5c subtypes
          exist (<a href="#supp1" itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary
            file 1</a> – outgoing Tm5c). In the identified pale and yellow columns of the
          medulla-7-column connectome, there were two Tm5c cells reliably contacted by R7–8, with
          &gt;10 synapses <span itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite
              itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib96"><span>96</span><span>Takemura et
                  al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib7"><span>7</span><span>Clements
                  et al.</span><span>2020</span></a></cite></span>. These two cells also showed a
          bias for yellow R8 input, with respectively 18 and 11 synapses from yellow R8 cells,
          versus 5 and 0 synapses from pale R8 and R7 combined.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The Tm20 cell type is a known
          columnar target of R8 <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib95"><span>95</span><span>Takemura
                  et al.</span><span>2013</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib96"><span>96</span><span>Takemura
                  et al.</span><span>2015</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite></span>, and the four Tm20 cells located in
          our seed columns were indeed selectively connected to R8 (<a href="#fig4s1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4—figure supplement 1C</a>, <a
            href="#fig1s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1—figure
            supplement 2D</a>). The Tm20 and Tm5c cell types together received 140 synapses from
          seed column photoreceptors, making them two of the most targeted cell types (<a
            href="#table2" itemscope="" itemtype="http://schema.stenci.la/Link">Table 2</a>). We
          also found one TmY10 cell that received seven synapses from our seed column photoreceptors
          (<a href="#supp1" itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary file
            1</a> – TmY10). In addition, we partially reconstructed 10 other Tm cells with a mean of
          4.4 photoreceptor synapses per cell. We did not fully reconstruct these lightly innervated
          Tm cells; Tm subtypes may manifest subtle differences in morphology and connectivity that
          require multiple examples to distinguish <span itemscope=""
            itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib32"><span>32</span><span>Jagadish
                  et al.</span><span>2014</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib21"><span>21</span><span>Gao et
                  al.</span><span>2008</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a
                href="#bib17"><span>17</span><span>Fischbach and
                  Dittrich</span><span>1989</span></a></cite></span>, which was beyond the scope of
          our targeted reconstruction.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">We found one more prominent
          cell type projecting to the lobula, which we refer to as the medulla-to-lobula cell type
          ML1 (<a href="#fig4" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4D</a>).
          We completely reconstructed one cell and used light microscopy data to explore the anatomy
          of the population (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4Dv-–vi</a>), and we estimate that there
          are <sub itemscope="" itemtype="http://schema.stenci.la/Subscript">45 cells per optic lobe
            (counts of 44, 44, 45, and 47 from four optic lobes). These cells projected to the
            deepest layer of the lobula and also to the adjacent central brain, with cell bodies in
            the anterior medulla cell body rind (<a href="#fig4" itemscope=""
              itemtype="http://schema.stenci.la/Link">Figure 4Dv</a>). They were morphologically
            similar to a putative <em itemscope=""
              itemtype="http://schema.stenci.la/Emphasis">ort</em>-expressing cell identified by
            <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
                href="#bib21"><span>21</span><span>Gao et al.</span><span>2008</span></a></cite>;
            (see their Figure S6). ML1 dendrites covered </sub>20 medulla columns with overlap, and
          the population covered the medulla (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4Dii</a>,vi), ramifying from vertical
          processes in layers M1-4, and also in M8 (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4Diii</a>,v). Unlike the Tm cells, the
          ML1 axons exited the distal surface of the medulla and traveled anteriorly to enter and
          terminate in or near lobula layer 6 (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4Diii</a>, v, vi), providing an alternate
          pathway connecting the medulla to the lobula. Light microscopy suggests that a fraction of
          the cells also formed synapses in the central brain, in the posterior lateral
          protocerebrum (PLP) (<a href="#fig4" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 4Dvi</a>, arrow). The input to the lobula
          was non-columnar, and although it was not strictly retinotopically organized, it was
          spatially organized, with two axon bundles originating in the dorsal and ventral medulla
          terminated in two general locations, incompletely covering the lobula (<a href="#fig4s2"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4—figure supplement 2</a>).
          Our seed columns contacted four ML1 cells, making an average of 25 synapses per ML1 cell.
          The cell was exclusively targeted by R8s from both pale and yellow columns (<a
            href="#fig4" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 4Div</a>).</p>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="visual-projection-neurons-connecting-r78-with-the-central-brain">Visual projection
          neurons connecting R7–8 with the central brain</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Nearly 10% of the synapses made
          by the central seed column R7–8 were with cells projecting directly to the central brain
          (<a href="#table2" itemscope="" itemtype="http://schema.stenci.la/Link">Table 2</a>). Of
          these, the strongest targets were the MeTu cells, which resemble Tm cells, but instead of
          sending axons to the lobula, projected to the AOTU via the anterior optic tract (<cite
            itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib16"><span>16</span><span>Fischbach and
                Lyly-Hünerberg</span><span>1983</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib66"><span>66</span><span>Otsuna et
                al.</span><span>2014</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib65"><span>65</span><span>Otsuna and
                Ito</span><span>2006</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib64"><span>64</span><span>Omoto et
                al.</span><span>2017</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib98"><span>98</span><span>Timaeus et
                al.</span><span>2020</span></a></cite>; <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib93"><span>93</span><span>Tai et
                al.</span><span>2021</span></a></cite>; <a href="#fig5" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5A</a>). Our reconstructions confirmed
          that MeTu cells were targets of R7 <cite itemscope=""
            itemtype="http://schema.stenci.la/Cite"><a href="#bib98"><span>98</span><span>Timaeus et
                al.</span><span>2020</span></a></cite>, and that their photoreceptor input was
          exclusively from R7 (<a href="#fig5" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5Aiv</a>). In total MeTu cells received
          15% of all the seed column R7 synapses (<a href="#table2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Table 2</a>). We found seven such neurons and
          reconstructed the complete morphology of one. Their dendrites overlapped and covered
          ~20–30 columns (<a href="#fig5" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5Aii</a>), while the axons all targeted
          the lateral tip of the AOTU (<cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib98"><span>98</span><span>Timaeus et al.</span><span>2020</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib64"><span>64</span><span>Omoto et al.</span><span>2017</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib93"><span>93</span><span>Tai et al.</span><span>2021</span></a></cite>; <a
            href="#fig5" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5Ai</a>).</p>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig5" title="Figure 5.">
          <label data-itemprop="label">Figure 5.</label><img src="index.html.media/fig5.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="visual-projection-neurons-vpn-connecting-r78-with-the-central-brain">Visual
              projection neurons (VPN) connecting R7–8 with the central brain.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A,B,E</strong>) Synapses between R7 and R8
              and MeTu (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">A</strong>),
              ML-VPN1 (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>),
              and Mt-VPN1 (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">E</strong>) cells. Panels i–iii: Anatomy
              of reconstructed cells. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">i</strong>) Side view. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">ii</strong>) Top view.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">iii</strong>) Side
              view of medulla branches. R7 synapses are indicated in purple, R8 synapses in green in
              ii, iii. (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">iv</strong>)
              Layer distribution of R7 and R8 inputs. Scale bars: 10 µm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) The MeTu cell shown was fully
              reconstructed. (Ai) Inset shows a magnified view of axon projections to the anterior
              optic tubercle (AOTU). (Aiv) All seven MeTu cells were exclusively R7 targets.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">B</strong>) The
              ML-VPN1 cell shown was fully reconstructed. (Bi) ML-VPN1 cells project to the PLP.
              (Biv) Both ML-VPN1 cells were pale R8 targets. (Ci–vi) Light microscopy of ML-VPN1
              anatomy. (Ci,Cii) Side view (Ci) and top view (Cii) of the population of ML-VPN1
              cells. (Ciii) Side view of a single MCFO-labeled ML-VPN1 cells. (Civ) Top view of
              multiple MCFO-labeled ML-VPN1 cells. (Cv) Overlay of arbors of a single cell ML-VPN1
              cell with L2 terminals (gray) indicating medulla columns. Images in Ci–Cv show
              overlays of aligned confocal images with the standard brain used for registration
              (Ci–iv) or a second registered image showing L2 terminals (Cv). (Cvi) Confocal
              substack projection showing medulla columns at approximately the level of R8
              terminals. ML-VPN1 (red) and photoreceptor axons (blue) are shown without (top) and
              with (bottom) labeling of yellow R8 axons (Rh6&gt; green). Overlap between ML1 and
              photoreceptors is largely limited to pale columns (i.e. columns without the Rh6
              marker). (Ci–vi) Scale bars: 20 µm. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) Reconstructions of three aMe12
              cells (orange, turquoise, purple) covering the entire medulla, with axons leaving via
              the accessory medulla and innervating the mushroom body calyces (CA) and the PLP and
              accessory medulla (AME) of both hemispheres. (Di) Frontal view. (Dii) Dorsal view.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">E</strong>) Mt-VPN1
              cells. (Eiv) Tracing of Mt-VPN1 photoreceptor synapses in 16 additional columns did
              not confirm yellow specificity found in the seed columns.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig5s1"
          title="Figure 5—figure supplement 1."><label data-itemprop="label">Figure 5—figure
            supplement 1.</label><img src="index.html.media/fig5-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="pale-specificity-of-ml-vpn1">Pale-specificity of ML-VPN1.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Side view of R7 and R8
              photoreceptors (blue) and ML-VPN1 cells (red), without (Ai) and with (Aii) Rh5
              expression (green), from confocal microscopy. (Ai) Four vertical processes that
              traverse layers 1–3 are labeled by arrows; in our electron microscopy (EM)
              reconstructions the photoreceptor synapses were largely located on such characteristic
              processes (<a href="#fig5" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
                5Biii</a>). Most vertical processes that followed photoreceptors (long arrows, left)
              were in pale (Rh5-positive) columns; vertical processes that did not follow
              photoreceptors (short arrows, right) were frequently found in yellow (Rh5-negative)
              columns or could not be readily assigned to a column. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Projection through a few
              adjacent confocal slices showing ML-VPN1 and photoreceptor axons at approximately the
              level of R8 terminals, with color-coded image channels as in A, without (Bi) and with
              (Bii) pale R8 columns labeled by the Rh5 marker. Overlap between ML1 and R-cells is
              largely limited to pale columns. For example, out of 43 putative overlaps circled
              (Biii), only four did not overlap with pale R8 expression (Biv, yellow thick circles),
              indicating that 93% of putative innervated columns were pale in this image. (<strong
                itemscope="" itemtype="http://schema.stenci.la/Strong">A–B</strong>) Scale bars: 20
              μm.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig5s2"
          title="Figure 5—figure supplement 2."><label data-itemprop="label">Figure 5—figure
            supplement 2.</label><img src="index.html.media/fig5-figsupp2.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="all-additional-neurons-connecting-r78-to-the-central-brain-with-≥3-synapses">All
              additional neurons connecting R7–8 to the central brain with ≥3 synapses.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) R7 and R8 connections with a
              neuron matching the anatomy of a known octopaminergic cell type (OA-AL2i3, skid
              14286406). The same reconstructed cell is shown in Ai–iii. (Ai) Side view, showing the
              projections to the flange (Fla), inferior posterior slope (IPS), and superior
              posterior slope (SPS). (Aii) Top view with R7 (purple) and R8 (green) synapses. (Aiii)
              Side view with R7 (purple) and R8 (green) synapses. The cell has processes leaving the
              medulla that track the photoreceptors, where it received synaptic input in our seed
              columns. Synapse totals: one yellow R7, three yellow R8. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) R8 connections with the
              reconstructed Mt-VPN cell with skid 11453464. (Bi) Side view, showing the projection
              to the SPS. (Bii) Top view with R8 (green) synapses. (Biii) Side view with R8 (green)
              synapses. Synapse totals: 11 yellow R7. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) R8 connections with the
              reconstructed Mt-VPN cell with skid 11469481l. (Ci) Side view, showing the projections
              to the lobula (Lob) and accessory medulla (aMe). (Cii) Top view with R8 (green)
              synapses. (Ciii) Side view with R8 (green) synapses. Synapse totals: five yellow R8.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">D</strong>) R8
              connections with the reconstructed Mt-VPN cell with skid 3509520, which is also a
              heterolateral lobula late tangential cell. (Di) Side view, showing the projections to
              the lobula plate (LP) and IPS in both hemispheres. (Dii) Top view with R8 (green)
              synapses. (Diii) Side view with R8 (green) synapses. Synapse totals: three pale R8.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">A–D</strong>) Scale
              bars: 10 μm.</p>
          </figcaption>
        </figure>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The presence of MeTu cells was
          the largest discrepancy by synapse count between our list of R7 targets and those of the
          medulla-7-column connectome (<cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib7"><span>7</span><span>Clements et al.</span><span>2020</span></a></cite>;
          <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib96"><span>96</span><span>Takemura et al.</span><span>2015</span></a></cite>;
          <a href="#fig1s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1—figure
            supplement 2E</a>), which was focused on columnar cell types and did not identify MeTu
          cells. In the medulla-7-column connectome, we identified a partially reconstructed Tm cell
          (<a href="#fig1s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 1—figure
            supplement 2F</a>) and several cells annotated as Dm7 as potential matches to MeTu
          cells. We did not identify any Dm7 cells postsynaptic to R7 in our data. We confirmed
          details of the connectivity of our MeTu neurons that were found for the medulla-7-column
          connectome putative Dm7 neurons (including strong inputs from Dm2 and Mi15 neurons), and
          we propose that the partially reconstructed Tm cells and also Dm7 cells in the 7-column
          data set were most likely MeTu cells, resolving the largest (numerical) discrepancy
          between the data sets, and underscoring the benefit of reconstructing small circuits in
          whole-brain EM volumes.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">Among the photoreceptor target
          cells projecting to the central brain, we identified a second cell type whose axonal
          projections follow the anterior axonal tracts of the ML1 neuron, which we refer to here as
          ML-VPN1 (<a href="#fig5" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            5B</a>). The cell bodies were located near the anterior proximal medulla. In our match
          using light microscopic data, the dendrites of individual neurons overlap, with each cell
          spanning tens of columns, collectively covering the medulla (<a href="#fig5" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5Ci–vi</a>), and we estimate <sub
            itemscope="" itemtype="http://schema.stenci.la/Subscript">65 cell bodies per optic lobe
            (counts of 64, 64, 65, and 68 from four optic lobes). The dendrites ramified along the
            border of M7 and M8, with vertical processes reaching up and spreading laterally in M3
            and again vertically up to M1 (<a href="#fig5" itemscope=""
              itemtype="http://schema.stenci.la/Link">Figure 5Bii–iii and Ciii</a>). Although the
            ML-VPN1 axons followed the ML1 axonal tract, they innervated the PLP of the ipsilateral
            hemisphere, in a region just posterior to the optic glomeruli (<a href="#fig5"
              itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5Bi</a>, Ci). The ML-VPN1
            cells were almost exclusively targeted by the pale R8, with 8.7 seed pale R8 inputs per
            cell (mean, range 5–14), and just one yellow R8 input across the three cells connected
            to our seed column photoreceptors (<a href="#fig5" itemscope=""
              itemtype="http://schema.stenci.la/Link">Figure 5Biv</a>). Light microscopy of
            co-labeled ML-VPN1 neurons and either yellow R8 axons (labeled for Rh6 in <a
              href="#fig5" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5Cvi</a>) or
            pale R8 axons (labeled for Rh5 in <a href="#fig5s1" itemscope=""
              itemtype="http://schema.stenci.la/Link">Figure 5—figure supplement 1</a>) supported
            the pale preference seen in the EM data: </sub>90% of columns in which ML1 arbors and
          photoreceptors appeared to overlap were pale. Together, our data indicate that ML-VPN1
          neurons have a strong bias for pale R8 input.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The aMe12 cells were also R8
          targets, and the two contacted cells received 15 and 11 R8 synapses, and 2 and 2 R7
          synapses, respectively, in the seed columns (<a href="#fig1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 1D and Eiii</a>, <a href="#supp1"
            itemscope="" itemtype="http://schema.stenci.la/Link">Supplementary file 1</a> – aMe12
          outgoing). Their axons also targeted the PLP, although in different locations to ML-VPN1,
          but they did so in both hemispheres (<a href="#fig5" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5D</a>). In addition, aMe12 cells also
          projected to the mushroom body calyces of both hemispheres, as well as to the
          contralateral and ipsilateral accessory medulla and superior clamp (<a href="#fig5"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5Di</a>, Dii). All three
          aMe12 cells shared a characteristic branching pattern, but only one of them additionally
          innervated the contralateral accessory medulla (<a href="#fig5" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5Dii</a>). The aMe12 cell type is present
          in the hemibrain connectome, where it is also a strong input to γd Kenyon cells <span
            itemscope="" itemtype="http://schema.stenci.la/CiteGroup"><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib43"><span>43</span><span>Li et
                  al.</span><span>2020</span></a></cite><cite itemscope=""
              itemtype="http://schema.stenci.la/Cite"><a href="#bib84"><span>84</span><span>Scheffer
                  et al.</span><span>2020</span></a></cite></span>.</p>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">There were five additional
          tangential cells projecting to the central brain (medulla tangential [Mt]-VPNs) targeted
          by seed column R7–8, collectively receiving 25 synapses (one neuron in <a href="#fig5"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5E</a>, others in <a
            href="#fig5s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5—figure
            supplement 2</a>). The most targeted cell, which we refer to as Mt-VPN1, had processes
          in layer M7, with branches reaching up into layers M5–M6, where it received inputs from
          both seed column yellow R7s, and projected an axon to the PLP (<a href="#fig5"
            itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5E</a>). Despite the
          exclusive seed connections with yellow R7, Mt-VPN1 was not specific for yellow R7: we
          traced Mt-VPN1 in 20 columns, in which it received input from 13 yellow R7, and 7 pale R7
          cells. The remaining tangential cells included a match to an octopaminergic neuron
          (OA-AL2i3; <cite itemscope="" itemtype="http://schema.stenci.la/Cite"><a
              href="#bib4"><span>4</span><span>Busch et al.</span><span>2009</span></a></cite>; <a
            href="#fig5s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5—figure
            supplement 2A</a>). This cell had processes in the distal medulla in layers M1–M2 as
          well as processes reaching out into the chiasm which received photoreceptor input (<a
            href="#fig5s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5—figure
            supplement 2A</a> ii-iii), and an axon that ipsilaterally innervated the inferior and
          superior posterior slope, and the flange (<a href="#fig5s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5—figure supplement 2A</a> i). This cell
          was one of the rare cell types that formed synapses onto photoreceptors, making 5 synapses
          onto the R7-R8, but only in one yellow column (<a href="#supp1" itemscope=""
            itemtype="http://schema.stenci.la/Link">Supplementary file 1</a> – Mt-VPN). The
          remaining Mt-VPN cells were very lightly innervated by the seed column photoreceptors in
          multiple (<a href="#fig5s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            5—figure supplement 2C</a> ii) and single columns (<a href="#fig5s2" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 5—figure supplement 2Bii, Dii</a>), but
          may integrate large numbers of photoreceptor inputs as they covered many columns.
          Collectively they innervated the ipsilateral superior posterior slope, accessory medulla,
          and lobula, and in both hemispheres the inferior posterior slope and lobula plate (<a
            href="#fig5s2" itemscope="" itemtype="http://schema.stenci.la/Link">Figure 5—figure
            supplement 2B-D</a>), revealing multiple pathways for transmitting direct photoreceptor
          signals into the central brain.</p>
        <h3 itemscope="" itemtype="http://schema.stenci.la/Heading"
          id="synapses-between-r7-dra-and-r8-dra-and-with-medulla-cell-types">Synapses between
          R7-DRA and R8-DRA, and with medulla cell types</h3>
        <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">The following four sections
          present the first EM connectomic data for targets of the polarization-sensitive
          photoreceptors in the DRA of <em itemscope=""
            itemtype="http://schema.stenci.la/Emphasis">Drosophila</em>. We first describe the cell
          types targeted by photoreceptors in the DRA region that were also found in the central
          columns (<a href="#fig6" itemscope="" itemtype="http://schema.stenci.la/Link">Figure
            6</a>), followed by modality-specific Dm cell types connected exclusively to DRA inner
          photoreceptors (<a href="#fig7" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 7</a>), VPNs connecting the DRA region
          and central brain (<a href="#fig8" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 8</a>), and finally cell types only found
          in the DRA region (<a href="#fig9" itemscope=""
            itemtype="http://schema.stenci.la/Link">Figure 9</a>).</p>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig6" title="Figure 6.">
          <label data-itemprop="label">Figure 6.</label><img src="index.html.media/fig6.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="synapses-between-r7-dorsal-rim-area-dra-and-r8-dra-and-with-medulla-cell-types">
              Synapses between R7-dorsal rim area (DRA) and R8-DRA, and with medulla cell types.
            </h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Reciprocal synapses between
              R7-DRA and R8-DRA. Left: Side view of an R7- and R8-DRA cell with R7-DRA→R8-DRA
              (purple points) and R8-DRA→R7-DRA (green points). Right: Layer distribution of R7-DRA
              and R8-DRA reciprocal synapses in three columns. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Reciprocal synapses between
              Dm9 in the DRA region and R7-DRA and R8-DRA. (Bi) Left: Side view of a reconstructed
              Dm9 skeleton (gray) in the DRA region, with R7-DRA→Dm9 synapses (purple) and
              R8-DRA→Dm9 synapses (green). Right: Layer distribution of DRA photoreceptor inputs
              into Dm9. (Bii) Top view of Dm9 cell that connects to photoreceptors in both DRA
              (light red) and non-DRA columns (gray). (Biii) Left: Feedback synapses from Dm9 to
              R7-DRA (purple) and R8-DRA (green). Right: Layer distribution of Dm9 inputs into
              R7-DRA and R8-DRA. (Biv) DRA and non-DRA R7 (purple) and R8 (green) synapses to the
              same Dm9 cell. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Synapses between R7-DRA,
              R8-DRA, and Dm2. (Ci) Left: Side view of a Dm2 cell with synapses from R7-DRA (purple)
              and R8-DRA (green). Right: Layer distribution of R7-DRA and R8-DRA synapses onto four
              Dm2 cells. (Cii) Top view of Dm2 skeleton in the DRA region. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) Synapses between R7-DRA,
              R8-DRA, and Mi15. (Di) Left: Side view of a reconstructed Mi15 cell with R7-DRA→Mi15
              synapses (purple) and R8-DRA→Mi15 synapses (green). Right: Layer distribution of
              R7-DRA and R8-DRA synapses to four Mi15 cells. (Dii) Top view of Mi15 skeleton in the
              DRA region. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">E</strong>) Synapses between R7-DRA,
              R8-DRA, and Tm20. (Ei) Left: Side view of a reconstructed Tm20 cell with R8-DRA→Tm20
              synapses in green. Right: Layer distribution of R8-DRA input to three Tm20 cells.
              (Eii) Top view of Tm20 skeleton in the DRA region (all scale bars: 10 µm).</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig6s1"
          title="Figure 6—figure supplement 1."><label data-itemprop="label">Figure 6—figure
            supplement 1.</label><img src="index.html.media/fig6-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="synapses-between-inner-photoreceptors-in-both-the-central-and-dorsal-rim-area-dra-columns">
              Synapses between inner photoreceptors in both the central and dorsal rim area (DRA)
              columns.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Total number of R7 synapses
              onto R8 for all full reconstructed cells in the central columns (4) and R7-DRA onto
              R8-DRA in the DRA columns (3). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Total number of R8 synapses
              onto R7 for all full reconstructed cells in the central columns (4) and R8-DRA onto
              R7-DRA in the DRA columns (3). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Fraction of
              photoreceptor-to-photoreceptor synapses of the total output of R7 and R8 in the
              central columns, and of R7-DRA and R8-DRA in the DRA columns. Individual counts in
              colored circles mean for each group in black circle.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig6s2"
          title="Figure 6—figure supplement 2."><label data-itemprop="label">Figure 6—figure
            supplement 2.</label><img src="index.html.media/fig6-figsupp2.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="additional-cell-types-connected-to-r7-dorsal-rim-area-dra-and-r8-dra">Additional
              cell types connected to R7-dorsal rim area (DRA) and R8-DRA.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Synapses between R7-DRA,
              R8-DRA, and L1. (Ai) Left: Side view of a reconstructed L1 skeleton (dark gray),
              together with R7-DRA (purple) and R8-DRA (green) from the same column plus R7-DRA→L1
              synapses (purple) and R8-DRA→L1 synapses (green). Right: Synapse distribution (in
              synapses/μm) of all three reconstructed L1 cells from the three DRA seed columns
              across medulla layers. (Aii) Top view of the same L1 cell with R7-DRA→L1 synapses
              (purple) and R8-DRA→L1 synapses (green). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Synapses between R7-DRA,
              R8-DRA, and L3. (Bi) Left: Side view of a reconstructed L3 skeleton (dark gray),
              together with R7-DRA (purple) and R8-DRA (green) from the same column plus R7-DRA→L3
              synapses (purple) and R8-DRA→L3 synapses (green). Right: Synapse distribution (in
              synapses/μm) of all three reconstructed L3 cells from the three DRA seed columns
              across medulla layers. (Bii) Top view of the same L3 cell with R7-DRA→L3 synapses
              (purple) and R8-DRA→L3 synapses (green). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">C</strong>) Synapses between R7-DRA,
              R8-DRA, and Mi1. (Ci) Left: Side view of a reconstructed Mi1 skeleton (dark gray),
              together with R7-DRA (purple) and R8-DRA (green) from the same column plus R7-DRA→Mi1
              synapses (purple) and R8-DRA→Mi1 synapses (green). Right: Synapse distribution (in
              synapses/μm) of all three reconstructed Mi1 cells from the three DRA seed columns
              across medulla layers. (Cii) Top view of the same Mi1 cell with R7-DRA→Mi1 synapses
              (purple) and R8-DRA→Mi1 synapses (green). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) Synapses between R7-DRA,
              R8-DRA, and Dm11. (Di) Left: Side view of a reconstructed Dm11 skeleton (dark gray),
              together with R7-DRA (purple) and R8-DRA (green) plus R7-DRA→Dm11 synapses (purple)
              and R8-DRA→Dm11 synapses (green). Right: Synapse distribution (in synapses/μm) of one
              reconstructed Dm11 cell across medulla layers. Note that synapses between R7-DRA and
              R8-DRA→Dm11 were only found in one of the three DRA seed columns. (Dii) Top view of
              the same Dm11 cell with R7-DRA→Dm11 synapses (purple) and R8-DRA→Dm11 synapses
              (green). (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">E</strong>)
              Synapses between R8-DRA and Mi9. (Ei) Left: Side view of a reconstructed Mi9 skeleton
              (dark gray), together with R8-DRA (green) from the same column plus R8-DRA→Mi9
              synapses (green). Right: Synapse distribution (in synapses/μm) of two reconstructed
              Mi9 cells across medulla layers. Note that only in two of the three DRA seed columns
              R8-DRA→Mi9 synapses were found. (Eii) Top view of the same Mi9 cell with R8-DRA→Mi9
              synapses (green). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">F</strong>) Synapses between R8-DRA and a
              Tm5-like cell. (Fi) Left: Side view of a reconstructed Tm5-like skeleton (dark gray),
              together with R8-DRA (green) plus R8-DRA→ Tm5-like synapses (green). Right: Synapse
              distribution (in synapses/μm) of one Tm5-like cell across medulla layers. Note that in
              only one of the three DRA seed columns was such a cell found. (Fii) Top view of the
              same Tm5-like cell with R8-DRA→Tm5-like synapses (green). (Fiii) Lobula innervation of
              the Tm5-like cell.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig7" title="Figure 7.">
          <label data-itemprop="label">Figure 7.</label><img src="index.html.media/fig7.jpg" alt=""
            itemscope="" itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="dm8-like-photoreceptor-targets-in-the-dorsal-rim-area-dra-region">Dm8-like
              photoreceptor targets in the dorsal rim area (DRA) region.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Synapses between
              photoreceptors and Dm-DRA1 cells. (Ai) Left: Side view of a reconstructed Dm-DRA1
              (gray) innervated by R7-DRA (purple). Right: Distribution of R7-DRA synapses (purple)
              onto 20 Dm-DRA1 cells, plotted across medulla layers. (Aii) Top view of the same fully
              reconstructed Dm-DRA1 skeleton and R7-DRA inputs from the (polar) seed column. (Aiii)
              Top view of a light microscopic Dm-DRA1 single cell clone with processes leaving the
              DRA region. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) R7-DRA inputs into Dm-DRA1
              cells. (Bi–iii) Three skeletons of fully reconstructed Dm-DRA1 cells (gray) at
              different positions along the DRA (posterior, polar, and anterior) with all R7-DRA
              synapses (purple) originating from an average of 11 columns. (Biv) Distribution of
              R7-DRA synapses onto the three Dm-DRA1 cells from Bi–iii along the DRA region.
              (<strong itemscope="" itemtype="http://schema.stenci.la/Strong">C</strong>) Synapses
              between photoreceptors and Dm-DRA2 cells. (Ci) Left: Side view of one reconstructed
              Dm-DRA2 skeleton (gray) innervated by R8-DRA (green). Right: Layer distribution of DRA
              photoreceptor synapses onto 9 Dm-DRA2 cells. (Cii) Top view of the same fully
              reconstructed Dm-DRA2 skeleton and photoreceptor inputs from the (polar) seed column.
              (Ciii) Side view of a light microscopic Dm-DRA2 single cell clone with vertical
              processes (arrows in Ci and Ciii indicate vertical projections). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">D</strong>) Photoreceptor inputs to
              Dm-DRA2 cells. (Di–iii) Three skeletons of fully reconstructed Dm-DRA2 cells (gray) at
              different positions along the DRA (posterior, polar, and anterior) with all R8-DRA
              (green) synapses originating from an average of 11 columns. (Div) Distribution of
              R8-DRA (and few R7-DRA) synapses onto the three Dm-DRA2 cells from Di–iii along the
              DRA region. (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">E</strong>) Comparison of Dm-DRA1 and
              Dm-DRA2 connectivity. All reconstructed Dm-DRA1 skeletons connected to R7-DRA in the
              polar seed column (circled column, arrow). The saturation of blue color indicates
              strength of connectivity (from 3 to 15 synapses). (Eii) All Dm-DRA2 skeletons
              connected to R8-DRA in the polar seed column (circled column, arrow), blue color
              indicates the strength of connectivity (from 2 to 19 synapses). (Eiii) Side views of
              overlapping Dm-DRA1 and Dm-DRA2 cell skeletons with all R7-DRA and R8-DRA synapses
              (same cells as in Bii and Dii) (all scale bars: 10 µm).</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig7s1"
          title="Figure 7—figure supplement 1."><label data-itemprop="label">Figure 7—figure
            supplement 1.</label><img src="index.html.media/fig7-figsupp1.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="non-dorsal-rim-area-dra-photoreceptor-inputs-to-dm-dra-cells">Non-dorsal rim area
              (DRA) photoreceptor inputs to Dm-DRA cells.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Top view (Ai–Aiii) of three
              fully reconstructed Dm-DRA1 cells (same as in <a href="#fig7" itemscope=""
                itemtype="http://schema.stenci.la/Link">Figure 7B</a>) with all non-DRA R7 inputs
              marked (purple dots), as well as distribution of synapses along the DRA region (Aiv).
              Note the strong inputs into the posterior Dm-DRA1 cell, originating from an R7 cell at
              the DRA/non-DRA boundary, with a putative ‘mixed’ fate (Ai). (<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">B</strong>) Top view (Bi–Bii) of two fully
              reconstructed Dm-DRA2 cells (same as in <a href="#fig7" itemscope=""
                itemtype="http://schema.stenci.la/Link">Figure 7D</a>) with all non-DRA R7 inputs
              marked (purple dots), as well as distribution of synapses along the DRA region (Biii).
              Note that no non-DRA R7 synapses were found for the posterior Dm-DRA2.</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig7s2"
          title="Figure 7—figure supplement 2."><label data-itemprop="label">Figure 7—figure
            supplement 2.</label><img src="index.html.media/fig7-figsupp2.jpg" alt="" itemscope=""
            itemtype="http://schema.org/ImageObject">
          <figcaption>
            <h4 itemscope="" itemtype="http://schema.stenci.la/Heading"
              id="deep-projections-of-dm-dra1-cells">Deep projections of Dm-DRA1 cells.</h4>
            <p itemscope="" itemtype="http://schema.stenci.la/Paragraph">(<strong itemscope=""
                itemtype="http://schema.stenci.la/Strong">A</strong>) Top view (Ai–Aiii) of three
              fully traced Dm-DRA1 cells (same as in <a href="#fig7" itemscope=""
                itemtype="http://schema.stenci.la/Link">Figure 7B</a>) with pale and yellow fates of
              all non-DRA columns indicated. Deep projections of Dm-DRA1 cells do not seem to show
              any obvious preference for pale or yellow columns (all scale bars: 10 µm).</p>
          </figcaption>
        </figure>
        <figure itemscope="" itemtype="http://schema.stenci.la/Figure" id="fig7s3"
          title="Figure 7—figure supplement 3."><label data-itemprop="label">