Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex

Distinctions between cell types underpin organizational principles for nervous system function. Functional variation also exists between neurons of the same type. This is exemplified by correspondence between grid cell spatial scales and the synaptic integrative properties of stellate cells (SCs) in the medial entorhinal cortex. However, we know little about how functional variability is structured either within or between individuals. Using ex-vivo patch-clamp recordings from up to 55 SCs per mouse, we found that integrative properties vary between mice and, in contrast to the modularity of grid cell spatial scales, have a continuous dorsoventral organization. Our results constrain mechanisms for modular grid firing and provide evidence for inter-animal phenotypic variability among neurons of the same type. We suggest that neuron type properties are tuned to circuit-level set points that vary within and between animals.Read more…

Distinctions between cell types underpin organizational principles for nervous system function. Functional variation also exists between neurons of the same type. This is exemplified by correspondence between grid cell spatial scales and the synaptic integrative properties of stellate cells (SCs) in the medial entorhinal cortex. However, we know little about how functional variability is structured either within or between individuals. Using ex-vivo patch-clamp recordings from up to 55 SCs per mouse, we found that integrative properties vary between mice and, in contrast to the modularity of grid cell spatial scales, have a continuous dorsoventral organization. Our results constrain mechanisms for modular grid firing and provide evidence for inter-animal phenotypic variability among neurons of the same type. We suggest that neuron type properties are tuned to circuit-level set points that vary within and between animals.Read more…


Type Path Last modified Size Actions
pastoll-et-al-2020.references.bib 1 week, 6 days ago 23.5KiB
pastoll-et-al-2020.Rmd.media 1 week, 6 days ago 1.1MiB
pastoll-et-al-2020.Rmd 1 week, 6 days ago 108.5KiB
index.html.media 1 week, 6 days ago 2.3MiB
index.html 1 week, 6 days ago 448.2KiB
GapData 1 week, 6 days ago 19.0MiB
Functions.R 1 week, 6 days ago 40.1KiB
Data 1 week, 6 days ago 265.4KiB